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The 2008 season’s official transaction log: 1,164 trades, signings and releases involving major-league clubs, listed newest first.
| Date | Type | Player | From | To | Details |
|---|---|---|---|---|---|
| Dec 31, 2008 | Signed as free agent | Brian Fuentes | — | Los Angeles Angels of Anaheim | Free agent signing |
| Dec 31, 2008 | Signed as free agent | Mark Hendrickson | — | Baltimore Orioles | Free agent signing |
| Dec 31, 2008 | Signed as free agent | Aaron Miles | — | Chicago Cubs | Free agent signing |
| Dec 31, 2008 | Trade | Mark DeRosa | Chicago Cubs | Cleveland Indians | Trade |
| Dec 31, 2008 | Trade | Jeff Stevens | Cleveland Indians | Chicago Cubs | Trade |
| Dec 31, 2008 | Trade | Chris Archer | Cleveland Indians | Chicago Cubs | Trade |
| Dec 31, 2008 | Trade | John Gaub | Cleveland Indians | Chicago Cubs | Trade |
| Dec 31, 2008 | Signed | Phillips Valdez | — | Cleveland Indians | Amateur free agent signing |
| Dec 30, 2008 | Signed as free agent | Dave Borkowski | — | Philadelphia Phillies | Free agent signing |
| Dec 30, 2008 | Signed as free agent | Jason Ellison | — | Philadelphia Phillies | Free agent signing |
| Dec 30, 2008 | Signed as free agent | Mike Maroth | — | Toronto Blue Jays | Free agent signing |
| Dec 30, 2008 | Signed as free agent | Joe Nelson | — | Tampa Bay Rays | Free agent signing |
| Dec 29, 2008 | Signed as free agent | Michael Barrett | — | Toronto Blue Jays | Free agent signing |
| Dec 29, 2008 | Signed as free agent | Daniel Cabrera | — | Washington Nationals | Free agent signing |
| Dec 29, 2008 | Signed as free agent | Blaine Neal | — | Philadelphia Phillies | Free agent signing |
| Dec 28, 2008 | Signed as free agent | Josh Bard | — | Boston Red Sox | Free agent signing |
| Dec 28, 2008 | Signed as free agent | Brad Penny | — | Boston Red Sox | Free agent signing |
| Dec 27, 2008 | Signed as free agent | Willy Taveras | — | Cincinnati Reds | Free agent signing |
| Dec 26, 2008 | Signed as free agent | Chris Barnwell | — | Houston Astros | Free agent signing |
| Dec 26, 2008 | Signed as free agent | Kevin Correia | — | San Diego Padres | Free agent signing |
| Dec 26, 2008 | Signed as free agent | R. A. Dickey | — | Minnesota Twins | Free agent signing |
| Dec 26, 2008 | Signed as free agent | Randy Johnson | — | San Francisco Giants | Free agent signing |
| Dec 26, 2008 | Signed as free agent | Justin Lehr | — | Philadelphia Phillies | Free agent signing |
| Dec 25, 2008 | Signed as free agent | Scott Mathieson | — | Philadelphia Phillies | Free agent signing |
| Dec 23, 2008 | Signed as free agent | Chris Bootcheck | — | Pittsburgh Pirates | Free agent signing |
| Dec 23, 2008 | Signed as free agent | Ryan Braun | — | Chicago White Sox | Free agent signing |
| Dec 23, 2008 | Signed as free agent | Jamie Burke | — | Seattle Mariners | Free agent signing |
| Dec 23, 2008 | Signed as free agent | Kevin Cash | — | New York Yankees | Free agent signing |
| Dec 23, 2008 | Signed as free agent | Randy Choate | — | Tampa Bay Rays | Free agent signing |
| Dec 23, 2008 | Signed as free agent | Yurendell de Caster | — | Detroit Tigers | Free agent signing |
| Dec 23, 2008 | Signed as free agent | Wil Ledezma | — | Washington Nationals | Free agent signing |
| Dec 23, 2008 | Signed as free agent | Gustavo Molina | — | Washington Nationals | Free agent signing |
| Dec 23, 2008 | Signed as free agent | Omir Santos | — | New York Mets | Free agent signing |
| Dec 22, 2008 | Signed as free agent | Chris Britton | — | San Diego Padres | Free agent signing |
| Dec 22, 2008 | Signed as free agent | Raul Chavez | — | Toronto Blue Jays | Free agent signing |
| Dec 22, 2008 | Signed as free agent | J. J. Furmaniak | — | Philadelphia Phillies | Free agent signing |
| Dec 22, 2008 | Signed as free agent | Ray Olmedo | — | Tampa Bay Rays | Free agent signing |
| Dec 21, 2008 | Signed as free agent | Aaron Fultz | — | Cincinnati Reds | Free agent signing |
| Dec 21, 2008 | Signed as free agent | Freddy Guzman | — | Seattle Mariners | Free agent signing |
| Dec 20, 2008 | Signed as free agent | Lenny DiNardo | — | Kansas City Royals | Free agent signing |
| Dec 20, 2008 | Signed as free agent | Trot Nixon | — | Milwaukee Brewers | Free agent signing |
| Dec 20, 2008 | Signed as free agent | CC Sabathia | — | New York Yankees | Free agent signing |
| Dec 19, 2008 | Signed as free agent | Travis Blackley | — | Arizona Diamondbacks | Free agent signing |
| Dec 19, 2008 | Signed as free agent | Luke Hudson | — | Kansas City Royals | Free agent signing |
| Dec 19, 2008 | Signed as free agent | Greg Norton | — | Atlanta Braves | Free agent signing |
| Dec 19, 2008 | Signed as free agent | Juan Rivera | — | Los Angeles Angels of Anaheim | Free agent signing |
| Dec 19, 2008 | Signed as free agent | Scott Strickland | — | Los Angeles Dodgers | Free agent signing |
| Dec 19, 2008 | Signed as free agent | Mike Wood | — | Florida Marlins | Free agent signing |
| Dec 18, 2008 | Signed as free agent | Reggie Abercrombie | — | Houston Astros | Free agent signing |
| Dec 18, 2008 | Signed as free agent | Wes Bankston | — | Cincinnati Reds | Free agent signing |
| Dec 18, 2008 | Signed as free agent | Andres Blanco | — | Chicago Cubs | Free agent signing |
| Dec 18, 2008 | Signed as free agent | Aaron Boone | — | Houston Astros | Free agent signing |
| Dec 18, 2008 | Signed as free agent | Melvin Dorta | — | Baltimore Orioles | Free agent signing |
| Dec 18, 2008 | Signed as free agent | Chris Duffy | — | Milwaukee Brewers | Free agent signing |
| Dec 18, 2008 | Signed as free agent | Jesse Foppert | — | San Francisco Giants | Free agent signing |
| Dec 18, 2008 | Signed as free agent | Dave Krynzel | — | Baltimore Orioles | Free agent signing |
| Dec 18, 2008 | Signed as free agent | Jason Lane | — | Toronto Blue Jays | Free agent signing |
| Dec 18, 2008 | Signed as free agent | Chad Moeller | — | Baltimore Orioles | Free agent signing |
| Dec 18, 2008 | Signed as free agent | Tommy Murphy | — | Kansas City Royals | Free agent signing |
| Dec 18, 2008 | Signed as free agent | Corey Patterson | — | Washington Nationals | Free agent signing |
| Dec 18, 2008 | Signed as free agent | Brad Salmon | — | Chicago White Sox | Free agent signing |
| Dec 18, 2008 | Signed as free agent | Jorge Sosa | — | Washington Nationals | Free agent signing |
| Dec 18, 2008 | Signed as free agent | Oscar Villarreal | — | Kansas City Royals | Free agent signing |
| Dec 17, 2008 | Signed as free agent | Yorman Bazardo | — | Philadelphia Phillies | Free agent signing |
| Dec 17, 2008 | Signed as free agent | Chris Capuano | — | Milwaukee Brewers | Free agent signing |
| Dec 17, 2008 | Signed as free agent | Jose Castillo | — | Washington Nationals | Free agent signing |
| Dec 17, 2008 | Signed as free agent | Rafael Furcal | — | Los Angeles Dodgers | Free agent signing |
| Dec 17, 2008 | Signed as free agent | Wilkin Ruan | — | Philadelphia Phillies | Free agent signing |
| Dec 17, 2008 | Signed as free agent | Randy Ruiz | — | Toronto Blue Jays | Free agent signing |
| Dec 17, 2008 | Signed as free agent | Ray Sadler | — | Tampa Bay Rays | Free agent signing |
| Dec 17, 2008 | Signed as free agent | Joe Thurston | — | St. Louis Cardinals | Free agent signing |
| Dec 17, 2008 | Signed as free agent | Matt Treanor | — | Detroit Tigers | Free agent signing |
| Dec 16, 2008 | Signed as free agent | John Bale | — | Kansas City Royals | Free agent signing |
| Dec 16, 2008 | Signed as free agent | Denny Bautista | — | Pittsburgh Pirates | Free agent signing |
| Dec 16, 2008 | Signed as free agent | Gustavo Chacin | — | Washington Nationals | Free agent signing |
| Dec 16, 2008 | Signed as free agent | Casey Daigle | — | Texas Rangers | Free agent signing |
| Dec 16, 2008 | Signed as free agent | Joey Gathright | — | Chicago Cubs | Free agent signing |
| Dec 16, 2008 | Signed as free agent | Sean Henn | — | Minnesota Twins | Free agent signing |
| Dec 16, 2008 | Signed as free agent | Cesar Izturis | — | Baltimore Orioles | Free agent signing |
| Dec 16, 2008 | Signed as free agent | Garrett Jones | — | Pittsburgh Pirates | Free agent signing |
| Dec 16, 2008 | Signed as free agent | Juan Mateo | — | Pittsburgh Pirates | Free agent signing |
| Dec 16, 2008 | Signed as free agent | Laynce Nix | — | Cincinnati Reds | Free agent signing |
| Dec 16, 2008 | Signed as free agent | Andy Phillips | — | Pittsburgh Pirates | Free agent signing |
| Dec 16, 2008 | Signed as free agent | Jeff Salazar | — | Pittsburgh Pirates | Free agent signing |
| Dec 16, 2008 | Signed as free agent | Chris Smith | — | Milwaukee Brewers | Free agent signing |
| Dec 16, 2008 | Signed as free agent | Chris Stewart | — | Chicago White Sox | Free agent signing |
| Dec 16, 2008 | Signed as free agent | Terry Tiffee | — | Philadelphia Phillies | Free agent signing |
| Dec 15, 2008 | Signed as free agent | Adam Everett | — | Detroit Tigers | Free agent signing |
| Dec 15, 2008 | Signed as free agent | John Gall | — | Houston Astros | Free agent signing |
| Dec 15, 2008 | Signed as free agent | Eric Hull | — | Seattle Mariners | Free agent signing |
| Dec 15, 2008 | Signed as free agent | Bobby Keppel | — | Minnesota Twins | Free agent signing |
| Dec 15, 2008 | Signed as free agent | Doug Mathis | — | Texas Rangers | Free agent signing |
| Dec 15, 2008 | Signed as free agent | Jason Michaels | — | Houston Astros | Free agent signing |
| Dec 15, 2008 | Signed as free agent | Jamie Moyer | — | Philadelphia Phillies | Free agent signing |
| Dec 15, 2008 | Signed | Willians Astudillo | — | Philadelphia Phillies | Amateur free agent signing |
| Dec 14, 2008 | Signed as free agent | Freddie Bynum | — | Washington Nationals | Free agent signing |
| Dec 14, 2008 | Signed as free agent | Emiliano Fruto | — | Atlanta Braves | Free agent signing |
| Dec 14, 2008 | Signed as free agent | Norris Hopper | — | Cincinnati Reds | Free agent signing |
| Dec 13, 2008 | Signed as free agent | Kyle Farnsworth | — | Kansas City Royals | Free agent signing |
| Dec 13, 2008 | Signed as free agent | Jonathan Herrera | — | Colorado Rockies | Free agent signing |
| Dec 13, 2008 | Signed as free agent | Heath Phillips | — | Kansas City Royals | Free agent signing |
| Dec 13, 2008 | Signed | Yefri Perez | — | Florida Marlins | Amateur free agent signing |
| Dec 12, 2008 | Signed as free agent | Francis Beltran | — | San Francisco Giants | Free agent signing |
| Dec 12, 2008 | Signed as free agent | A. J. Burnett | — | New York Yankees | Free agent signing |
| Dec 12, 2008 | Signed as free agent | Matt Clement | — | Toronto Blue Jays | Free agent signing |
| Dec 12, 2008 | Signed as free agent | Luis Figueroa | — | Los Angeles Angels of Anaheim | Free agent signing |
| Dec 12, 2008 | Signed as free agent | Raul Ibanez | — | Philadelphia Phillies | Free agent signing |
| Dec 12, 2008 | Signed as free agent | Lance Niekro | — | Atlanta Braves | Free agent signing |
| Dec 12, 2008 | Signed as free agent | Arthur Rhodes | — | Cincinnati Reds | Free agent signing |
| Dec 12, 2008 | Signed as free agent | Eider Torres | — | Chicago White Sox | Free agent signing |
| Dec 12, 2008 | Signed as free agent | Ramon Vazquez | — | Pittsburgh Pirates | Free agent signing |
| Dec 12, 2008 | Signed | Dayan Viciedo | — | Chicago White Sox | Amateur free agent signing |
| Dec 12, 2008 | Trade | Scott Schoeneweis | New York Mets | Arizona Diamondbacks | Trade |
| Dec 12, 2008 | Trade | Connor Robertson | Arizona Diamondbacks | New York Mets | Trade |
| Dec 11, 2008 | Signed as free agent | Matt Kata | — | Houston Astros | Free agent signing |
| Dec 11, 2008 | Signed as free agent | Felipe Lopez | — | Arizona Diamondbacks | Free agent signing |
| Dec 11, 2008 | Signed as free agent | Nick Punto | — | Minnesota Twins | Free agent signing |
| Dec 11, 2008 | Signed as free agent | Horacio Ramirez | — | Kansas City Royals | Free agent signing |
| Dec 11, 2008 | Signed as free agent | Doug Waechter | — | Kansas City Royals | Free agent signing |
| Dec 11, 2008 | Trade | Beau Vaughan | Boston Red Sox | Texas Rangers | Trade |
| Dec 11, 2008 | Trade | Endy Chavez | New York Mets | Seattle Mariners | Trade |
| Dec 11, 2008 | Trade | Aaron Heilman | New York Mets | Seattle Mariners | Trade |
| Dec 11, 2008 | Trade | Maikel Cleto | New York Mets | Seattle Mariners | Trade |
| Dec 11, 2008 | Trade | Ezequiel Carrera | New York Mets | Seattle Mariners | Trade |
| Dec 11, 2008 | Trade | Mike Carp | New York Mets | Seattle Mariners | Trade |
| Dec 11, 2008 | Trade | Jason Vargas | New York Mets | Seattle Mariners | Trade |
| Dec 11, 2008 | Trade | J. J. Putz | Seattle Mariners | New York Mets | Trade |
| Dec 11, 2008 | Trade | Sean Green | Seattle Mariners | New York Mets | Trade |
| Dec 11, 2008 | Trade | Jeremy Reed | Seattle Mariners | New York Mets | Trade |
| Dec 11, 2008 | Trade | Joe Smith | New York Mets | Cleveland Indians | Trade |
| Dec 11, 2008 | Trade | Luis Valbuena | Seattle Mariners | Cleveland Indians | Trade |
| Dec 11, 2008 | Trade | Franklin Gutierrez | Cleveland Indians | Seattle Mariners | Trade |
| Dec 10, 2008 | Released | Jesus Colome | Washington Nationals | — | Release |
| Dec 10, 2008 | Signed as free agent | Alan Embree | — | Colorado Rockies | Free agent signing |
| Dec 10, 2008 | Signed as free agent | Enrique Gonzalez | — | Boston Red Sox | Free agent signing |
| Dec 10, 2008 | Released | Matt Treanor | Florida Marlins | — | Release |
| Dec 10, 2008 | Signed as free agent | Mike Vento | — | Washington Nationals | Free agent signing |
| Dec 10, 2008 | Signed as free agent | Kerry Wood | — | Cleveland Indians | Free agent signing |
| Dec 10, 2008 | Trade | Ronny Paulino | Pittsburgh Pirates | Philadelphia Phillies | Trade |
| Dec 10, 2008 | Trade | Jason Jaramillo | Philadelphia Phillies | Pittsburgh Pirates | Trade |
| Dec 10, 2008 | Trade | Edwin Jackson | Tampa Bay Rays | Detroit Tigers | Trade |
| Dec 10, 2008 | Trade | Matt Joyce | Detroit Tigers | Tampa Bay Rays | Trade |
| Dec 9, 2008 | Signed as free agent | Casey Blake | — | Los Angeles Dodgers | Free agent signing |
| Dec 9, 2008 | Signed as free agent | Joel Guzman | — | Washington Nationals | Free agent signing |
| Dec 9, 2008 | Signed as free agent | Mike Lamb | — | Milwaukee Brewers | Free agent signing |
| Dec 9, 2008 | Signed as free agent | Francisco Rodriguez | — | New York Mets | Free agent signing |
| Dec 9, 2008 | Signed as free agent | Chris Seddon | — | Seattle Mariners | Free agent signing |
| Dec 9, 2008 | Signed as free agent | Chris Shelton | — | Seattle Mariners | Free agent signing |
| Dec 9, 2008 | Signed as free agent | Jose Valdez | — | New York Yankees | Free agent signing |
| Dec 9, 2008 | Trade | Unnamed | Baltimore Orioles | Cincinnati Reds | $ |
| Dec 9, 2008 | Trade | Ramon Hernandez | Baltimore Orioles | Cincinnati Reds | Trade |
| Dec 9, 2008 | Trade | Ryan Freel | Cincinnati Reds | Baltimore Orioles | Trade |
| Dec 9, 2008 | Trade | Justin Turner | Cincinnati Reds | Baltimore Orioles | Trade |
| Dec 9, 2008 | Trade | Brandon Waring | Cincinnati Reds | Baltimore Orioles | Trade |
| Dec 9, 2008 | Signed | Lisalverto Bonilla | — | Philadelphia Phillies | Amateur free agent signing |
| Dec 8, 2008 | Signed as free agent | Eliezer Alfonzo | — | San Diego Padres | Free agent signing |
| Dec 8, 2008 | Signed as free agent | Mark Loretta | — | Los Angeles Dodgers | Free agent signing |
| Dec 7, 2008 | Signed as free agent | Darren Oliver | — | Los Angeles Angels of Anaheim | Free agent signing |
| Dec 7, 2008 | Signed as free agent | David Weathers | — | Cincinnati Reds | Free agent signing |
| Dec 7, 2008 | Trade | Gerald Laird | Texas Rangers | Detroit Tigers | Trade |
| Dec 7, 2008 | Trade | Guillermo Moscoso | Detroit Tigers | Texas Rangers | Trade |
| Dec 7, 2008 | Trade | Carlos Melo | Detroit Tigers | Texas Rangers | Trade |
| Dec 6, 2008 | Signed as free agent | Hector Luna | — | Los Angeles Dodgers | Free agent signing |
| Dec 5, 2008 | Signed as free agent | Jason Childers | — | Tampa Bay Rays | Free agent signing |
| Dec 5, 2008 | Signed as free agent | Andy Gonzalez | — | Florida Marlins | Free agent signing |
| Dec 5, 2008 | Signed as free agent | Justin Leone | — | New York Yankees | Free agent signing |
| Dec 5, 2008 | Signed as free agent | Todd Linden | — | New York Yankees | Free agent signing |
| Dec 5, 2008 | Signed as free agent | Adalberto Mendez | — | Florida Marlins | Free agent signing |
| Dec 5, 2008 | Signed as free agent | Tomo Ohka | — | Cleveland Indians | Free agent signing |
| Dec 5, 2008 | Signed as free agent | David Ross | — | Atlanta Braves | Free agent signing |
| Dec 5, 2008 | Released | Randy Ruiz | Minnesota Twins | — | Release |
| Dec 5, 2008 | Signed as free agent | John Van Benschoten | — | Chicago White Sox | Free agent signing |
| Dec 5, 2008 | Signed as free agent | Josh Wilson | — | Arizona Diamondbacks | Free agent signing |
| Dec 5, 2008 | Signed as free agent | Angel Castro | — | Chicago Cubs | Free agent signing |
| Dec 4, 2008 | Signed as free agent | Callix Crabbe | — | Seattle Mariners | Free agent signing |
| Dec 4, 2008 | Signed as free agent | Jorge Julio | — | Milwaukee Brewers | Free agent signing |
| Dec 4, 2008 | Signed as free agent | Mike Lincoln | — | Cincinnati Reds | Free agent signing |
| Dec 4, 2008 | Signed as free agent | Edgar Renteria | — | San Francisco Giants | Free agent signing |
| Dec 4, 2008 | Signed as free agent | Brian Slocum | — | Pittsburgh Pirates | Free agent signing |
| Dec 4, 2008 | Signed as free agent | Junichi Tazawa | — | Boston Red Sox | Free agent signing with first major-league team |
| Dec 4, 2008 | Trade | Mark Worrell | St. Louis Cardinals | San Diego Padres | Trade |
| Dec 4, 2008 | Trade | Khalil Greene | San Diego Padres | St. Louis Cardinals | Trade |
| Dec 4, 2008 | Trade | Brent Lillibridge | Atlanta Braves | Chicago White Sox | Trade |
| Dec 4, 2008 | Trade | Tyler Flowers | Atlanta Braves | Chicago White Sox | Trade |
| Dec 4, 2008 | Trade | Jon Gilmore | Atlanta Braves | Chicago White Sox | Trade |
| Dec 4, 2008 | Trade | Santos Rodriguez | Atlanta Braves | Chicago White Sox | Trade |
| Dec 4, 2008 | Trade | Javier Vazquez | Chicago White Sox | Atlanta Braves | Trade |
| Dec 4, 2008 | Trade | Boone Logan | Chicago White Sox | Atlanta Braves | Trade |
| Dec 3, 2008 | Signed as free agent | Doug Bernier | — | New York Yankees | Free agent signing |
| Dec 3, 2008 | Signed as free agent | Russell Branyan | — | Seattle Mariners | Free agent signing |
| Dec 3, 2008 | Signed as free agent | Nelson Figueroa | — | New York Mets | Free agent signing |
| Dec 3, 2008 | Signed as free agent | Chad Fox | — | Chicago Cubs | Free agent signing |
| Dec 3, 2008 | Signed as free agent | Brian Gordon | — | Texas Rangers | Free agent signing |
| Dec 3, 2008 | Signed as free agent | J. R. House | — | Kansas City Royals | Free agent signing |
| Dec 3, 2008 | Signed as free agent | Bob Howry | — | San Francisco Giants | Free agent signing |
| Dec 3, 2008 | Signed as free agent | Trever Miller | — | St. Louis Cardinals | Free agent signing |
| Dec 3, 2008 | Signed as free agent | Chris Richard | — | Tampa Bay Rays | Free agent signing |
| Dec 3, 2008 | Signed as free agent | Matt Tupman | — | Kansas City Royals | Free agent signing |
| Dec 2, 2008 | Signed as free agent | Doug Brocail | — | Houston Astros | Free agent signing |
| Dec 2, 2008 | Signed as free agent | Darnell McDonald | — | Cincinnati Reds | Free agent signing |
| Dec 2, 2008 | Signed as free agent | Franquelis Osoria | — | Kansas City Royals | Free agent signing |
| Dec 2, 2008 | Signed as free agent | Billy Traber | — | Boston Red Sox | Free agent signing |
| Dec 1, 2008 | Signed as free agent | Matt Carson | — | Oakland Athletics | Free agent signing |
| Dec 1, 2008 | Signed as free agent | Mike Hampton | — | Houston Astros | Free agent signing |
| Dec 1, 2008 | Signed as free agent | Mark Johnson | — | Chicago Cubs | Free agent signing |
| Dec 1, 2008 | Signed as free agent | Justin Knoedler | — | St. Louis Cardinals | Free agent signing |
| Dec 1, 2008 | Signed as free agent | Scott Thorman | — | Milwaukee Brewers | Free agent signing |
| Dec 1, 2008 | Signed as free agent | Jerome Williams | — | Oakland Athletics | Free agent signing |
| Dec 2008 | Signed as free agent | Wilson Valdez | — | Cleveland Indians | Free agent signing |
| Nov 29, 2008 | Signed as free agent | Mitch Jones | — | Los Angeles Dodgers | Free agent signing |
| Nov 29, 2008 | Signed as free agent | Chris Woodward | — | Seattle Mariners | Free agent signing |
| Nov 28, 2008 | Signed as free agent | Scott Chiasson | — | Baltimore Orioles | Free agent signing |
| Nov 28, 2008 | Signed as free agent | Travis Chick | — | Los Angeles Dodgers | Free agent signing |
| Nov 28, 2008 | Signed as free agent | Mike Koplove | — | Philadelphia Phillies | Free agent signing |
| Nov 28, 2008 | Signed as free agent | Erick Threets | — | Los Angeles Dodgers | Free agent signing |
| Nov 28, 2008 | Trade | Unnamed | Boston Red Sox | Texas Rangers | $ |
| Nov 28, 2008 | Trade | Wes Littleton | Texas Rangers | Boston Red Sox | Trade |
| Nov 26, 2008 | Released | Kameron Loe | Texas Rangers | — | Release |
| Nov 26, 2008 | Signed as free agent | Marcus McBeth | — | Boston Red Sox | Free agent signing |
| Nov 26, 2008 | Signed as free agent | Brian Myrow | — | Chicago White Sox | Free agent signing |
| Nov 25, 2008 | Signed as free agent | Jason Bourgeois | — | Milwaukee Brewers | Free agent signing |
| Nov 25, 2008 | Signed as free agent | Willie Collazo | — | Florida Marlins | Free agent signing |
| Nov 25, 2008 | Signed as free agent | John Lindsey | — | Florida Marlins | Free agent signing |
| Nov 25, 2008 | Signed as free agent | Vladimir Nunez | — | Atlanta Braves | Free agent signing |
| Nov 25, 2008 | Signed as free agent | R. J. Swindle | — | Milwaukee Brewers | Free agent signing |
| Nov 24, 2008 | Signed as free agent | Kevin Cameron | — | Oakland Athletics | Free agent signing |
| Nov 24, 2008 | Signed as free agent | Seth Etherton | — | Arizona Diamondbacks | Free agent signing |
| Nov 24, 2008 | Signed as free agent | J. D. Martin | — | Washington Nationals | Free agent signing |
| Nov 23, 2008 | Signed as free agent | Carmen Cali | — | Los Angeles Dodgers | Free agent signing |
| Nov 22, 2008 | Signed as free agent | Guillermo Rodriguez | — | Baltimore Orioles | Free agent signing |
| Nov 22, 2008 | Signed as free agent | Ross Wolf | — | Baltimore Orioles | Free agent signing |
| Nov 21, 2008 | Signed as free agent | Ron Flores | — | Cincinnati Reds | Free agent signing |
| Nov 21, 2008 | Signed as free agent | Jason Waddell | — | Chicago Cubs | Free agent signing |
| Nov 21, 2008 | Signed as free agent | Eli Whiteside | — | San Francisco Giants | Free agent signing |
| Nov 20, 2008 | Signed as free agent | Greg Aquino | — | Cleveland Indians | Free agent signing |
| Nov 20, 2008 | Signed as free agent | Rick Bauer | — | Toronto Blue Jays | Free agent signing |
| Nov 20, 2008 | Signed as free agent | Brad Eldred | — | Washington Nationals | Free agent signing |
| Nov 20, 2008 | Signed as free agent | Paul McAnulty | — | Boston Red Sox | Free agent signing |
| Nov 20, 2008 | Signed as free agent | Pete Orr | — | Washington Nationals | Free agent signing |
| Nov 20, 2008 | Signed as free agent | Elizardo Ramirez | — | Texas Rangers | Free agent signing |
| Nov 20, 2008 | Signed as free agent | Rene Rivera | — | New York Mets | Free agent signing |
| Nov 20, 2008 | Signed as free agent | Dane Sardinha | — | Detroit Tigers | Free agent signing |
| Nov 20, 2008 | Released | Les Walrond | Toronto Blue Jays | — | Release |
| Nov 20, 2008 | Signed as free agent | Randy Williams | — | Chicago White Sox | Free agent signing |
| Nov 20, 2008 | Trade | Greg Golson | Philadelphia Phillies | Texas Rangers | Trade |
| Nov 20, 2008 | Trade | John Mayberry | Texas Rangers | Philadelphia Phillies | Trade |
| Nov 19, 2008 | Signed as free agent | Kevin Barker | — | Cincinnati Reds | Free agent signing |
| Nov 19, 2008 | Signed as free agent | Ryan Dempster | — | Chicago Cubs | Free agent signing |
| Nov 19, 2008 | Signed as free agent | Brian Esposito | — | Houston Astros | Free agent signing |
| Nov 19, 2008 | Signed as free agent | Joe Hietpas | — | New York Mets | Free agent signing |
| Nov 19, 2008 | Signed as free agent | Ryan Jorgensen | — | Cincinnati Reds | Free agent signing |
| Nov 19, 2008 | Signed as free agent | Chris Schroder | — | Oakland Athletics | Free agent signing |
| Nov 19, 2008 | Trade | Coco Crisp | Boston Red Sox | Kansas City Royals | Trade |
| Nov 19, 2008 | Trade | Ramon Ramirez | Kansas City Royals | Boston Red Sox | Trade |
| Nov 18, 2008 | Signed as free agent | Mike Cervenak | — | Philadelphia Phillies | Free agent signing |
| Nov 18, 2008 | Signed as free agent | Brooks Conrad | — | Atlanta Braves | Free agent signing |
| Nov 18, 2008 | Signed as free agent | Andy Green | — | New York Mets | Free agent signing |
| Nov 18, 2008 | Signed as free agent | Jesus Guzman | — | San Francisco Giants | Free agent signing |
| Nov 18, 2008 | Signed as free agent | Luis Hernandez | — | Kansas City Royals | Free agent signing |
| Nov 18, 2008 | Signed as free agent | Mel Stocker | — | Seattle Mariners | Free agent signing |
| Nov 17, 2008 | Signed as free agent | Jeremy Affeldt | — | San Francisco Giants | Free agent signing |
| Nov 17, 2008 | Signed as free agent | Brad Hennessey | — | Baltimore Orioles | Free agent signing |
| Nov 17, 2008 | Signed as free agent | Luis Maza | — | Los Angeles Dodgers | Free agent signing |
| Nov 17, 2008 | Signed as free agent | Corky Miller | — | Chicago White Sox | Free agent signing |
| Nov 17, 2008 | Signed as free agent | Brian Sanches | — | Florida Marlins | Free agent signing |
| Nov 17, 2008 | Signed as free agent | Ryan Wagner | — | Washington Nationals | Free agent signing |
| Nov 15, 2008 | Signed as free agent | Donnie Murphy | — | Baltimore Orioles | Free agent signing |
| Nov 15, 2008 | Signed | Oscar Taveras | — | St. Louis Cardinals | Amateur free agent signing |
| Nov 14, 2008 | Signed as free agent | Jesse English | — | San Francisco Giants | Free agent signing |
| Nov 13, 2008 | Trade | Kevin Gregg | Florida Marlins | Chicago Cubs | Trade |
| Nov 13, 2008 | Trade | Jose Ceda | Chicago Cubs | Florida Marlins | Trade |
| Nov 13, 2008 | Trade | Wilson Betemit | New York Yankees | Chicago White Sox | Trade |
| Nov 13, 2008 | Trade | Jeff Marquez | New York Yankees | Chicago White Sox | Trade |
| Nov 13, 2008 | Trade | Jhonny Nunez | New York Yankees | Chicago White Sox | Trade |
| Nov 13, 2008 | Trade | Nick Swisher | Chicago White Sox | New York Yankees | Trade |
| Nov 13, 2008 | Trade | Kanekoa Texeira | Chicago White Sox | New York Yankees | Trade |
| Nov 12, 2008 | Released | Rodrigo Lopez | Atlanta Braves | — | Release |
| Nov 12, 2008 | Released | Jean Machi | Toronto Blue Jays | — | Release |
| Nov 12, 2008 | Signed as free agent | Damaso Marte | — | New York Yankees | Free agent signing |
| Nov 10, 2008 | Signed as free agent | Robert Coello | — | Boston Red Sox | Free agent signing |
| Nov 10, 2008 | Signed as free agent | Justin Miller | — | San Francisco Giants | Free agent signing |
| Nov 10, 2008 | Signed as free agent | Josh Phelps | — | San Francisco Giants | Free agent signing |
| Nov 10, 2008 | Signed as free agent | Gil Velazquez | — | Boston Red Sox | Free agent signing |
| Nov 10, 2008 | Trade | Emilio Bonifacio | Washington Nationals | Florida Marlins | Trade |
| Nov 10, 2008 | Trade | P.J. Dean | Washington Nationals | Florida Marlins | Trade |
| Nov 10, 2008 | Trade | Jake Smolinski | Washington Nationals | Florida Marlins | Trade |
| Nov 10, 2008 | Trade | Scott Olsen | Florida Marlins | Washington Nationals | Trade |
| Nov 10, 2008 | Trade | Josh Willingham | Florida Marlins | Washington Nationals | Trade |
| Nov 10, 2008 | Trade | Matt Holliday | Colorado Rockies | Oakland Athletics | Trade |
| Nov 10, 2008 | Trade | Carlos Gonzalez | Oakland Athletics | Colorado Rockies | Trade |
| Nov 10, 2008 | Trade | Huston Street | Oakland Athletics | Colorado Rockies | Trade |
| Nov 10, 2008 | Trade | Greg Smith | Oakland Athletics | Colorado Rockies | Trade |
| Nov 7, 2008 | Signed as free agent | LaTroy Hawkins | — | Houston Astros | Free agent signing |
| Nov 7, 2008 | Signed as free agent | Pedro Strop | — | Texas Rangers | Free agent signing |
| Nov 7, 2008 | Signed | Elias Diaz | — | Pittsburgh Pirates | Amateur free agent signing |
| Nov 6, 2008 | Signed as free agent | Ben Davis | — | Cincinnati Reds | Free agent signing |
| Nov 6, 2008 | Signed as free agent | Ryan Roberts | — | Arizona Diamondbacks | Free agent signing |
| Nov 5, 2008 | Released | So Taguchi | Philadelphia Phillies | — | Release |
| Nov 3, 2008 | Signed as free agent | Ryan Langerhans | — | Washington Nationals | Free agent signing |
| Nov 3, 2008 | Signed as free agent | Sergio Mitre | — | New York Yankees | Free agent signing |
| Nov 3, 2008 | Trade | Ryan Buchter | Washington Nationals | Chicago Cubs | Trade |
| Nov 3, 2008 | Trade | Matt Avery | Chicago Cubs | Washington Nationals | Trade |
| Nov 3, 2008 | Signed | Arismendy Alcantara | — | Chicago Cubs | Amateur free agent signing |
| Oct 31, 2008 | Signed as free agent | Andy Cannizaro | — | Cleveland Indians | Free agent signing |
| Oct 31, 2008 | Signed as free agent | Jason LaRue | — | St. Louis Cardinals | Free agent signing |
| Oct 31, 2008 | Trade | Mike Jacobs | Florida Marlins | Kansas City Royals | Trade |
| Oct 31, 2008 | Trade | Juan Carlos Oviedo | Kansas City Royals | Florida Marlins | Trade |
| Oct 31, 2008 | Signed as free agent | Chia-Jen Lo | — | Houston Astros | Free agent signing with first major-league team |
| Oct 28, 2008 | Signed as free agent | Jayson Nix | — | Chicago White Sox | Free agent signing |
| Oct 25, 2008 | Signed as free agent | Jumbo Diaz | — | Texas Rangers | Free agent signing |
| Oct 24, 2008 | Signed as free agent | Adam Loewen | — | Toronto Blue Jays | Free agent signing |
| Oct 24, 2008 | Released | Kip Wells | Kansas City Royals | — | Release |
| Oct 22, 2008 | Signed as free agent | Scott McClain | — | San Francisco Giants | Free agent signing |
| Oct 20, 2008 | Released | Angel Castro | Detroit Tigers | — | Release |
| Oct 9, 2008 | Signed | Eugenio Suarez | — | Detroit Tigers | Amateur free agent signing |
| Oct 8, 2008 | Signed | Yordano Ventura | — | Kansas City Royals | Amateur free agent signing |
| Oct 3, 2008 | Trade | Michael Brantley | Milwaukee Brewers | Cleveland Indians | Trade |
| Oct 2, 2008 | Released | Francisco Rosario | Philadelphia Phillies | — | Release |
| Oct 1, 2008 | Released | Randy Choate | Milwaukee Brewers | — | Release |
| Oct 1, 2008 | Signed | Steven Moya | — | Detroit Tigers | Amateur free agent signing |
| Sep 30, 2008 | Released | Sergio Mitre | Florida Marlins | — | Release |
| Sep 30, 2008 | Trade | Eduardo Perez | Los Angeles Dodgers | San Diego Padres | Trade |
| Sep 30, 2008 | Trade | Mike Watt | Los Angeles Dodgers | San Diego Padres | Trade |
| Sep 29, 2008 | Trade | Fabio Castro | Philadelphia Phillies | Toronto Blue Jays | Trade |
| Sep 29, 2008 | Signed | Gift Ngoepe | — | Pittsburgh Pirates | Amateur free agent signing |
| Sep 24, 2008 | Signed as free agent | J. T. Snow | — | San Francisco Giants | Free agent signing |
| Sep 19, 2008 | Released | Pedro Strop | Colorado Rockies | — | Release |
| Sep 18, 2008 | Released | Alberto Reyes | New York Mets | — | Release |
| Sep 16, 2008 | Signed | C. C. Lee | — | Cleveland Indians | Amateur free agent signing |
| Sep 12, 2008 | Released | Scott Chiasson | Baltimore Orioles | — | Release |
| Sep 12, 2008 | Released | Julio Manon | Baltimore Orioles | — | Release |
| Sep 12, 2008 | Trade | Micah Owings | Arizona Diamondbacks | Cincinnati Reds | Trade |
| Sep 9, 2008 | Released | Mike Sweeney | Oakland Athletics | — | Release |
| Sep 6, 2008 | Released | Tanyon Sturtze | Los Angeles Dodgers | — | Release |
| Sep 5, 2008 | Released | Kurt Birkins | Tampa Bay Rays | — | Release |
| Sep 5, 2008 | Released | Fernando Cabrera | Baltimore Orioles | — | Release |
| Sep 5, 2008 | Signed as free agent | Tadahito Iguchi | — | Philadelphia Phillies | Free agent signing |
| Sep 5, 2008 | Released | Mike Lamb | Minnesota Twins | — | Release |
| Sep 5, 2008 | Signed as free agent | Mike Lamb | — | Milwaukee Brewers | Free agent signing |
| Sep 5, 2008 | Released | Anastacio Martinez | Detroit Tigers | — | Release |
| Sep 5, 2008 | Signed as free agent | Alfredo Simon | — | Baltimore Orioles | Free agent signing |
| Sep 4, 2008 | Signed | Ariel Hernandez | — | San Francisco Giants | Amateur free agent signing |
| Sep 3, 2008 | Signed | Juan Minaya | — | Houston Astros | Amateur free agent signing |
| Sep 2, 2008 | Released | Ty Taubenheim | Pittsburgh Pirates | — | Release |
| Sep 1, 2008 | Released | Mike Difelice | Tampa Bay Rays | — | Release |
| Sep 1, 2008 | Released | Tadahito Iguchi | San Diego Padres | — | Release |
| Sep 1, 2008 | Released | Bobby Kielty | Minnesota Twins | — | Release |
| Sep 1, 2008 | Released | Guillermo Rodriguez | San Francisco Giants | — | Release |
| Sep 1, 2008 | Released | Brett Tomko | San Diego Padres | — | Release |
| Aug 31, 2008 | Released | Alex Serrano | Los Angeles Angels of Anaheim | — | Release |
| Aug 31, 2008 | Trade | David Eckstein | Toronto Blue Jays | Arizona Diamondbacks | Trade |
| Aug 31, 2008 | Trade | Chad Beck | Arizona Diamondbacks | Toronto Blue Jays | Trade |
| Aug 30, 2008 | Released | Kris Benson | Philadelphia Phillies | — | Release |
| Aug 30, 2008 | Trade | Matt Stairs | Toronto Blue Jays | Philadelphia Phillies | Trade |
| Aug 29, 2008 | Signed | Jose Urena | — | Florida Marlins | Amateur free agent signing |
| Aug 27, 2008 | Signed as free agent | Elmer Dessens | — | Atlanta Braves | Free agent signing |
| Aug 27, 2008 | Trade | Mark Kotsay | Atlanta Braves | Boston Red Sox | Trade |
| Aug 27, 2008 | Trade | Luis Sumoza | Boston Red Sox | Atlanta Braves | Trade |
| Aug 26, 2008 | Signed | Erik Gonzalez | — | Cleveland Indians | Amateur free agent signing |
| Aug 25, 2008 | Trade | Robinzon Diaz | Toronto Blue Jays | Pittsburgh Pirates | Trade |
| Aug 25, 2008 | Trade | Eddie Guardado | Texas Rangers | Minnesota Twins | Trade |
| Aug 25, 2008 | Trade | Mark Hamburger | Minnesota Twins | Texas Rangers | Trade |
| Aug 23, 2008 | Released | Casey Daigle | Minnesota Twins | — | Release |
| Aug 22, 2008 | Signed as free agent | Rodrigo Lopez | — | Atlanta Braves | Free agent signing |
| Aug 22, 2008 | Signed as free agent | David Ross | — | Boston Red Sox | Free agent signing |
| Aug 21, 2008 | Signed as free agent | Alberto Reyes | — | New York Mets | Free agent signing |
| Aug 21, 2008 | Trade | Jose Bautista | Pittsburgh Pirates | Toronto Blue Jays | Trade |
| Aug 21, 2008 | Signed | Hansel Robles | — | New York Mets | Amateur free agent signing |
| Aug 20, 2008 | Trade | Anderson Hernandez | New York Mets | Washington Nationals | Trade |
| Aug 20, 2008 | Signed | Jonathan Schoop | — | Baltimore Orioles | Amateur free agent signing |
| Aug 19, 2008 | Signed as free agent | Jason Lane | — | Boston Red Sox | Free agent signing |
| Aug 19, 2008 | Released | David Ross | Cincinnati Reds | — | Release |
| Aug 19, 2008 | Signed as free agent | Kip Wells | — | Kansas City Royals | Free agent signing |
| Aug 19, 2008 | Trade | Greg Maddux | San Diego Padres | Los Angeles Dodgers | Trade |
| Aug 18, 2008 | Released | Jason Lane | New York Yankees | — | Release |
| Aug 17, 2008 | Trade | Luis Ayala | Washington Nationals | New York Mets | Trade |
| Aug 17, 2008 | Signed | Christian Villanueva | — | Texas Rangers | Amateur free agent signing |
| Aug 15, 2008 | Released | Richie Sexson | New York Yankees | — | Release |
| Aug 15, 2008 | Released | Josh Towers | Colorado Rockies | — | Release |
| Aug 15, 2008 | Signed | Yorman Rodriguez | — | Cincinnati Reds | Amateur free agent signing |
| Aug 14, 2008 | Signed as free agent | Brian Rogers | — | New York Mets | Free agent signing |
| Aug 14, 2008 | Released | Jason Shiell | Milwaukee Brewers | — | Release |
| Aug 14, 2008 | Released | Kip Wells | Colorado Rockies | — | Release |
| Aug 14, 2008 | Trade | Wilkin Castillo | Arizona Diamondbacks | Cincinnati Reds | Trade |
| Aug 14, 2008 | Signed | Matt Shoemaker | — | Los Angeles Angels of Anaheim | Amateur free agent signing |
| Aug 13, 2008 | Released | Jose Vidro | Seattle Mariners | — | Release |
| Aug 12, 2008 | Signed as free agent | Scott Chiasson | — | Baltimore Orioles | Free agent signing |
| Aug 12, 2008 | Signed as free agent | Freddy Garcia | — | Detroit Tigers | Free agent signing |
| Aug 12, 2008 | Released | Ben Howard | Milwaukee Brewers | — | Release |
| Aug 12, 2008 | Signed as free agent | Oscar Villarreal | — | Colorado Rockies | Free agent signing |
| Aug 12, 2008 | Trade | Paul Byrd | Cleveland Indians | Boston Red Sox | Trade |
| Aug 11, 2008 | Signed as free agent | JD Closser | — | San Diego Padres | Free agent signing |
| Aug 11, 2008 | Signed as free agent | Bobby Kielty | — | Minnesota Twins | Free agent signing |
| Aug 11, 2008 | Released | Shannon Stewart | Toronto Blue Jays | — | Release |
| Aug 11, 2008 | Trade | Unnamed | Cincinnati Reds | Arizona Diamondbacks | $ |
| Aug 11, 2008 | Trade | Adam Dunn | Cincinnati Reds | Arizona Diamondbacks | Trade |
| Aug 11, 2008 | Trade | Dallas Buck | Arizona Diamondbacks | Cincinnati Reds | Trade |
| Aug 9, 2008 | Signed as free agent | Gary Glover | — | Detroit Tigers | Free agent signing |
| Aug 9, 2008 | Signed as free agent | Paul Lo Duca | — | Florida Marlins | Free agent signing |
| Aug 9, 2008 | Released | Brian Rogers | Detroit Tigers | — | Release |
| Aug 9, 2008 | Signed | Amauri Sanit | — | New York Yankees | Amateur free agent signing |
| Aug 9, 2008 | Trade | Horacio Ramirez | Kansas City Royals | Chicago White Sox | Trade |
| Aug 9, 2008 | Trade | Paulo Orlando | Chicago White Sox | Kansas City Royals | Trade |
| Aug 8, 2008 | Released | Micah Bowie | Houston Astros | — | Release |
| Aug 8, 2008 | Released | Craig Monroe | Minnesota Twins | — | Release |
| Aug 8, 2008 | Released | Oscar Villarreal | Seattle Mariners | — | Release |
| Aug 7, 2008 | Signed as free agent | Justin Lehr | — | Cincinnati Reds | Free agent signing |
| Aug 7, 2008 | Trade | Scott Eyre | Chicago Cubs | Philadelphia Phillies | Trade |
| Aug 7, 2008 | Trade | Brian Schlitter | Philadelphia Phillies | Chicago Cubs | Trade |
| Aug 6, 2008 | Released | JD Closser | New York Yankees | — | Release |
| Aug 6, 2008 | Released | John Ennis | Philadelphia Phillies | — | Release |
| Aug 6, 2008 | Signed as free agent | Joe Valentine | — | Cincinnati Reds | Free agent signing |
| Aug 5, 2008 | Signed as free agent | Felipe Lopez | — | St. Louis Cardinals | Free agent signing |
| Aug 4, 2008 | Signed as free agent | Eric DuBose | — | Los Angeles Dodgers | Free agent signing |
| Aug 3, 2008 | Signed as free agent | Roberto Novoa | — | San Francisco Giants | Free agent signing |
| Aug 2, 2008 | Released | Matt Clement | St. Louis Cardinals | — | Release |
| Aug 1, 2008 | Released | Mike Kinkade | Seattle Mariners | — | Release |
| Aug 1, 2008 | Signed as free agent | Ramon Martinez | — | New York Mets | Free agent signing |
| Aug 1, 2008 | Signed as free agent | Marty McLeary | — | Toronto Blue Jays | Free agent signing |
| Aug 1, 2008 | Signed as free agent | Chris Michalak | — | Oakland Athletics | Free agent signing |
| Jul 31, 2008 | Released | Johnny Estrada | Washington Nationals | — | Release |
| Jul 31, 2008 | Signed as free agent | Josh Labandeira | — | Kansas City Royals | Free agent signing |
| Jul 31, 2008 | Released | Paul Lo Duca | Washington Nationals | — | Release |
| Jul 31, 2008 | Released | Felipe Lopez | Washington Nationals | — | Release |
| Jul 31, 2008 | Signed as free agent | Victor Zambrano | — | New York Yankees | Free agent signing |
| Jul 31, 2008 | Trade | Unnamed | Cincinnati Reds | Chicago White Sox | $ |
| Jul 31, 2008 | Trade | Ken Griffey | Cincinnati Reds | Chicago White Sox | Trade |
| Jul 31, 2008 | Trade | Nick Masset | Chicago White Sox | Cincinnati Reds | Trade |
| Jul 31, 2008 | Trade | Danny Richar | Chicago White Sox | Cincinnati Reds | Trade |
| Jul 31, 2008 | Trade | Manny Ramirez | Boston Red Sox | Los Angeles Dodgers | Trade |
| Jul 31, 2008 | Trade | Jason Bay | Pittsburgh Pirates | Boston Red Sox | Trade |
| Jul 31, 2008 | Trade | Craig Hansen | Boston Red Sox | Pittsburgh Pirates | Trade |
| Jul 31, 2008 | Trade | Brandon Moss | Boston Red Sox | Pittsburgh Pirates | Trade |
| Jul 31, 2008 | Trade | Andy LaRoche | Los Angeles Dodgers | Pittsburgh Pirates | Trade |
| Jul 31, 2008 | Trade | Bryan Morris | Los Angeles Dodgers | Pittsburgh Pirates | Trade |
| Jul 31, 2008 | Trade | Arthur Rhodes | Seattle Mariners | Florida Marlins | Trade |
| Jul 31, 2008 | Trade | Gaby Hernandez | Florida Marlins | Seattle Mariners | Trade |
| Jul 31, 2008 | Trade | Jhonny Nunez | Washington Nationals | New York Yankees | Trade |
| Jul 31, 2008 | Trade | Alberto Gonzalez | New York Yankees | Washington Nationals | Trade |
| Jul 30, 2008 | Signed as free agent | Jason Stanford | — | Chicago Cubs | Free agent signing |
| Jul 30, 2008 | Trade | Matt Cusick | Houston Astros | New York Yankees | Trade |
| Jul 30, 2008 | Trade | LaTroy Hawkins | New York Yankees | Houston Astros | Trade |
| Jul 30, 2008 | Trade | Ivan Rodriguez | Detroit Tigers | New York Yankees | Trade |
| Jul 30, 2008 | Trade | Kyle Farnsworth | New York Yankees | Detroit Tigers | Trade |
| Jul 30, 2008 | Signed | Felipe Vazquez | — | Tampa Bay Rays | Amateur free agent signing |
| Jul 29, 2008 | Released | Chris Michalak | Florida Marlins | — | Release |
| Jul 29, 2008 | Released | Matt Miller | Pittsburgh Pirates | — | Release |
| Jul 29, 2008 | Released | Roberto Novoa | Baltimore Orioles | — | Release |
| Jul 29, 2008 | Trade | Mark Teixeira | Atlanta Braves | Los Angeles Angels of Anaheim | Trade |
| Jul 29, 2008 | Trade | Casey Kotchman | Los Angeles Angels of Anaheim | Atlanta Braves | Trade |
| Jul 29, 2008 | Trade | Stephen Marek | Los Angeles Angels of Anaheim | Atlanta Braves | Trade |
| Jul 28, 2008 | Signed as free agent | Carlos Hernandez | — | Tampa Bay Rays | Free agent signing |
| Jul 28, 2008 | Signed as free agent | Heath Phillips | — | Tampa Bay Rays | Free agent signing |
| Jul 28, 2008 | Signed as free agent | Tom Shearn | — | Minnesota Twins | Free agent signing |
| Jul 27, 2008 | Signed as free agent | Josh Hall | — | Colorado Rockies | Free agent signing |
| Jul 26, 2008 | Released | Josh Labandeira | Tampa Bay Rays | — | Release |
| Jul 26, 2008 | Signed as free agent | Jason Tyner | — | Chicago White Sox | Free agent signing |
| Jul 26, 2008 | Trade | Xavier Nady | Pittsburgh Pirates | New York Yankees | Trade |
| Jul 26, 2008 | Trade | Damaso Marte | Pittsburgh Pirates | New York Yankees | Trade |
| Jul 26, 2008 | Trade | Jeff Karstens | New York Yankees | Pittsburgh Pirates | Trade |
| Jul 26, 2008 | Trade | Ross Ohlendorf | New York Yankees | Pittsburgh Pirates | Trade |
| Jul 26, 2008 | Trade | Daniel McCutchen | New York Yankees | Pittsburgh Pirates | Trade |
| Jul 26, 2008 | Trade | Jose Tabata | New York Yankees | Pittsburgh Pirates | Trade |
| Jul 26, 2008 | Trade | Anthony Reyes | St. Louis Cardinals | Cleveland Indians | Trade |
| Jul 26, 2008 | Trade | Luis Perdomo | Cleveland Indians | St. Louis Cardinals | Trade |
| Jul 26, 2008 | Trade | Unnamed | Cleveland Indians | Los Angeles Dodgers | $ |
| Jul 26, 2008 | Trade | Casey Blake | Cleveland Indians | Los Angeles Dodgers | Trade |
| Jul 26, 2008 | Trade | Jon Meloan | Los Angeles Dodgers | Cleveland Indians | Trade |
| Jul 26, 2008 | Trade | Carlos Santana | Los Angeles Dodgers | Cleveland Indians | Trade |
| Jul 25, 2008 | Released | Marcus Gwyn | Florida Marlins | — | Release |
| Jul 25, 2008 | Released | Esteban Loaiza | Chicago White Sox | — | Release |
| Jul 24, 2008 | Released | Mark Bellhorn | Los Angeles Dodgers | — | Release |
| Jul 24, 2008 | Released | Jim Brower | Houston Astros | — | Release |
| Jul 24, 2008 | Released | Ramon Martinez | Los Angeles Dodgers | — | Release |
| Jul 24, 2008 | Released | Chris Resop | Atlanta Braves | — | Release |
| Jul 24, 2008 | Signed as free agent | Mike Ryan | — | Florida Marlins | Free agent signing |
| Jul 24, 2008 | Signed as free agent | Jorge Sosa | — | Seattle Mariners | Free agent signing |
| Jul 24, 2008 | Released | Jason Tyner | Cleveland Indians | — | Release |
| Jul 22, 2008 | Signed | Brandon Beachy | — | Atlanta Braves | Amateur free agent signing |
| Jul 22, 2008 | Signed as free agent | Jay Gibbons | — | Milwaukee Brewers | Free agent signing |
| Jul 22, 2008 | Released | Matt Riley | Los Angeles Dodgers | — | Release |
| Jul 22, 2008 | Trade | Randy Wolf | San Diego Padres | Houston Astros | Trade |
| Jul 22, 2008 | Trade | Chad Reineke | Houston Astros | San Diego Padres | Trade |
| Jul 22, 2008 | Trade | Jon Rauch | Washington Nationals | Arizona Diamondbacks | Trade |
| Jul 22, 2008 | Trade | Emilio Bonifacio | Arizona Diamondbacks | Washington Nationals | Trade |
| Jul 21, 2008 | Signed as free agent | Kevin Mahar | — | Philadelphia Phillies | Free agent signing |
| Jul 21, 2008 | Released | Fernando Seguignol | Detroit Tigers | — | Release |
| Jul 21, 2008 | Signed | Alfredo Gonzalez | — | Houston Astros | Amateur free agent signing |
| Jul 20, 2008 | Signed as free agent | Pablo Ozuna | — | Los Angeles Dodgers | Free agent signing |
| Jul 20, 2008 | Released | Esteban Yan | Baltimore Orioles | — | Release |
| Jul 20, 2008 | Trade | Ray Durham | San Francisco Giants | Milwaukee Brewers | Trade |
| Jul 20, 2008 | Trade | Darren Ford | Milwaukee Brewers | San Francisco Giants | Trade |
| Jul 20, 2008 | Trade | Steve Hammond | Milwaukee Brewers | San Francisco Giants | Trade |
| Jul 19, 2008 | Signed as free agent | Jim Brower | — | Houston Astros | Free agent signing |
| Jul 19, 2008 | Released | Heath Phillips | New York Yankees | — | Release |
| Jul 19, 2008 | Signed as free agent | Oscar Villarreal | — | Seattle Mariners | Free agent signing |
| Jul 19, 2008 | Trade | Juan Castro | Colorado Rockies | Baltimore Orioles | Trade |
| Jul 19, 2008 | Trade | Mike McCoy | Baltimore Orioles | Colorado Rockies | Trade |
| Jul 17, 2008 | Signed as free agent | Richie Sexson | — | New York Yankees | Free agent signing |
| Jul 17, 2008 | Trade | Joe Blanton | Oakland Athletics | Philadelphia Phillies | Trade |
| Jul 17, 2008 | Trade | Josh Outman | Philadelphia Phillies | Oakland Athletics | Trade |
| Jul 17, 2008 | Trade | Adrian Cardenas | Philadelphia Phillies | Oakland Athletics | Trade |
| Jul 17, 2008 | Trade | Matthew Spencer | Philadelphia Phillies | Oakland Athletics | Trade |
| Jul 17, 2008 | Trade | Tony Clark | San Diego Padres | Arizona Diamondbacks | Trade |
| Jul 17, 2008 | Trade | Evan Scribner | Arizona Diamondbacks | San Diego Padres | Trade |
| Jul 16, 2008 | Released | Jorge Sosa | Houston Astros | — | Release |
| Jul 14, 2008 | Released | Jim Brower | Chicago Cubs | — | Release |
| Jul 14, 2008 | Released | Alex Escobar | Washington Nationals | — | Release |
| Jul 13, 2008 | Released | Juan Padilla | New York Mets | — | Release |
| Jul 12, 2008 | Released | Bobby Kielty | Boston Red Sox | — | Release |
| Jul 11, 2008 | Signed as free agent | Rick Bauer | — | Toronto Blue Jays | Free agent signing |
| Jul 11, 2008 | Released | Charlton Jimerson | Seattle Mariners | — | Release |
| Jul 11, 2008 | Signed as free agent | Jason Kershner | — | Seattle Mariners | Free agent signing |
| Jul 11, 2008 | Signed as free agent | Eric Milton | — | New York Yankees | Free agent signing |
| Jul 10, 2008 | Released | Joe Borowski | Cleveland Indians | — | Release |
| Jul 10, 2008 | Signed as free agent | Randy Messenger | — | Seattle Mariners | Free agent signing |
| Jul 10, 2008 | Released | Richie Sexson | Seattle Mariners | — | Release |
| Jul 9, 2008 | Released | Randy Messenger | San Francisco Giants | — | Release |
| Jul 9, 2008 | Signed | Luis Cessa | — | New York Mets | Amateur free agent signing |
| Jul 8, 2008 | Signed as free agent | Julian Tavarez | — | Atlanta Braves | Free agent signing |
| Jul 8, 2008 | Trade | Rich Harden | Oakland Athletics | Chicago Cubs | Trade |
| Jul 8, 2008 | Trade | Chad Gaudin | Oakland Athletics | Chicago Cubs | Trade |
| Jul 8, 2008 | Trade | Sean Gallagher | Chicago Cubs | Oakland Athletics | Trade |
| Jul 8, 2008 | Trade | Matt Murton | Chicago Cubs | Oakland Athletics | Trade |
| Jul 8, 2008 | Trade | Eric Patterson | Chicago Cubs | Oakland Athletics | Trade |
| Jul 8, 2008 | Trade | Josh Donaldson | Chicago Cubs | Oakland Athletics | Trade |
| Jul 7, 2008 | Released | Anderson Garcia | Seattle Mariners | — | Release |
| Jul 7, 2008 | Released | Greg Jones | Los Angeles Dodgers | — | Release |
| Jul 7, 2008 | Trade | CC Sabathia | Cleveland Indians | Milwaukee Brewers | Trade |
| Jul 7, 2008 | Trade | Zach Jackson | Milwaukee Brewers | Cleveland Indians | Trade |
| Jul 7, 2008 | Trade | Matt LaPorta | Milwaukee Brewers | Cleveland Indians | Trade |
| Jul 7, 2008 | Trade | Rob Bryson | Milwaukee Brewers | Cleveland Indians | Trade |
| Jul 6, 2008 | Released | Marcos Carvajal | Florida Marlins | — | Release |
| Jul 5, 2008 | Signed as free agent | Jeff Weaver | — | Cleveland Indians | Free agent signing |
| Jul 4, 2008 | Signed as free agent | Ben Broussard | — | New York Yankees | Free agent signing |
| Jul 4, 2008 | Signed as free agent | Kiko Calero | — | Texas Rangers | Free agent signing |
| Jul 4, 2008 | Signed as free agent | Josh Labandeira | — | Tampa Bay Rays | Free agent signing |
| Jul 4, 2008 | Signed | Ramon Flores | — | New York Yankees | Amateur free agent signing |
| Jul 4, 2008 | Signed | Omar Narvaez | — | Tampa Bay Rays | Amateur free agent signing |
| Jul 3, 2008 | Signed as free agent | Cory Aldridge | — | Kansas City Royals | Free agent signing |
| Jul 3, 2008 | Signed as free agent | Micah Bowie | — | Houston Astros | Free agent signing |
| Jul 3, 2008 | Released | Ben Broussard | Chicago Cubs | — | Release |
| Jul 3, 2008 | Signed as free agent | Tommy Murphy | — | Florida Marlins | Free agent signing |
| Jul 3, 2008 | Signed | Odubel Herrera | — | Texas Rangers | Amateur free agent signing |
| Jul 2, 2008 | Signed as free agent | Eric Cyr | — | Los Angeles Dodgers | Free agent signing |
| Jul 2, 2008 | Signed as free agent | Andy Green | — | New York Mets | Free agent signing |
| Jul 2, 2008 | Released | Josh Labandeira | Tampa Bay Rays | — | Release |
| Jul 2, 2008 | Released | Tommy Murphy | Washington Nationals | — | Release |
| Jul 2, 2008 | Signed as free agent | Chris Stewart | — | New York Yankees | Free agent signing |
| Jul 2, 2008 | Signed | Edwin Escobar | — | Texas Rangers | Amateur free agent signing |
| Jul 2, 2008 | Signed | Dixon Machado | — | Detroit Tigers | Amateur free agent signing |
| Jul 2, 2008 | Signed | Gio Urshela | — | Cleveland Indians | Amateur free agent signing |
| Jul 2, 2008 | Signed | William Cuevas | — | Boston Red Sox | Amateur free agent signing |
| Jul 2, 2008 | Signed | Michael Ynoa | — | Oakland Athletics | Amateur free agent signing |
| Jul 1, 2008 | Released | Kane Davis | Toronto Blue Jays | — | Release |
| Jul 1, 2008 | Released | Raul Gonzalez | New York Mets | — | Release |
| Jul 1, 2008 | Released | Andy Green | Cincinnati Reds | — | Release |
| Jul 1, 2008 | Signed as free agent | Andy Van Hekken | — | Houston Astros | Free agent signing |
| Jun 29, 2008 | Released | Eric Reed | New York Mets | — | Release |
| Jun 28, 2008 | Released | Ezequiel Astacio | Cincinnati Reds | — | Release |
| Jun 27, 2008 | Released | Kiko Calero | Oakland Athletics | — | Release |
| Jun 27, 2008 | Signed as free agent | Jose Capellan | — | Kansas City Royals | Free agent signing |
| Jun 27, 2008 | Signed as free agent | Troy Cate | — | Milwaukee Brewers | Free agent signing |
| Jun 27, 2008 | Signed as free agent | Ryan Drese | — | Pittsburgh Pirates | Free agent signing |
| Jun 27, 2008 | Signed as free agent | Rob Mackowiak | — | Cincinnati Reds | Free agent signing |
| Jun 27, 2008 | Released | Kevin Thompson | Pittsburgh Pirates | — | Release |
| Jun 27, 2008 | Signed as free agent | Brett Tomko | — | San Diego Padres | Free agent signing |
| Jun 27, 2008 | Released | Jamie Vermilyea | Toronto Blue Jays | — | Release |
| Jun 27, 2008 | Released | Scott Williamson | Seattle Mariners | — | Release |
| Jun 27, 2008 | Signed | Eury De La Rosa | — | Arizona Diamondbacks | Amateur free agent signing |
| Jun 26, 2008 | Released | Shawn Chacon | Houston Astros | — | Release |
| Jun 26, 2008 | Signed | Ildemaro Vargas | — | St. Louis Cardinals | Amateur free agent signing |
| Jun 25, 2008 | Signed as free agent | Chris George | — | Toronto Blue Jays | Free agent signing |
| Jun 25, 2008 | Released | Jason Kershner | Philadelphia Phillies | — | Release |
| Jun 25, 2008 | Signed as free agent | Jason Phillips | — | Atlanta Braves | Free agent signing |
| Jun 25, 2008 | Released | Julian Tavarez | Milwaukee Brewers | — | Release |
| Jun 25, 2008 | Signed as free agent | Jerome Williams | — | Los Angeles Dodgers | Free agent signing |
| Jun 25, 2008 | Trade | Denny Bautista | Detroit Tigers | Pittsburgh Pirates | Trade |
| Jun 25, 2008 | Trade | Kyle Pearson | Pittsburgh Pirates | Detroit Tigers | Trade |
| Jun 24, 2008 | Signed as free agent | Tony Graffanino | — | Cleveland Indians | Free agent signing |
| Jun 24, 2008 | Signed as free agent | Juan Rincon | — | Cleveland Indians | Free agent signing |
| Jun 23, 2008 | Released | John Koronka | Colorado Rockies | — | Release |
| Jun 23, 2008 | Released | Dustan Mohr | Colorado Rockies | — | Release |
| Jun 23, 2008 | Trade | Nelson Payano | Atlanta Braves | Seattle Mariners | Trade |
| Jun 22, 2008 | Signed as free agent | Val Majewski | — | Houston Astros | Free agent signing |
| Jun 22, 2008 | Released | Joe Valentine | Philadelphia Phillies | — | Release |
| Jun 22, 2008 | Signed | Bo Schultz | — | Oakland Athletics | Amateur free agent signing |
| Jun 21, 2008 | Released | Brett Tomko | Kansas City Royals | — | Release |
| Jun 21, 2008 | Released | Jose Valentin | New York Mets | — | Release |
| Jun 20, 2008 | Signed | Steve Geltz | — | Los Angeles Angels of Anaheim | Amateur free agent signing |
| Jun 20, 2008 | Signed as free agent | Mitch Jones | — | Los Angeles Dodgers | Free agent signing |
| Jun 19, 2008 | Signed as free agent | Adam Melhuse | — | Colorado Rockies | Free agent signing |
| Jun 19, 2008 | Signed as free agent | Sidney Ponson | — | New York Yankees | Free agent signing |
| Jun 19, 2008 | Signed as free agent | Clay Zavada | — | Arizona Diamondbacks | Free agent signing |
| Jun 18, 2008 | Released | Andy Cavazos | Chicago Cubs | — | Release |
| Jun 18, 2008 | Signed as free agent | Zack Segovia | — | Washington Nationals | Free agent signing |
| Jun 18, 2008 | Signed | Miguel Gonzalez | — | Chicago White Sox | Amateur free agent signing |
| Jun 17, 2008 | Signed as free agent | Morgan Ensberg | — | Cleveland Indians | Free agent signing |
| Jun 17, 2008 | Released | Chris George | Colorado Rockies | — | Release |
| Jun 16, 2008 | Released | Sidney Ponson | Texas Rangers | — | Release |
| Jun 15, 2008 | Released | Bartolome Fortunato | San Francisco Giants | — | Release |
| Jun 15, 2008 | Signed as free agent | Scott Williamson | — | Seattle Mariners | Free agent signing |
| Jun 14, 2008 | Released | Ben Davis | Baltimore Orioles | — | Release |
| Jun 14, 2008 | Released | Josh Paul | Houston Astros | — | Release |
| Jun 13, 2008 | Released | Jason Botts | Texas Rangers | — | Release |
| Jun 13, 2008 | Released | Aaron Fultz | Colorado Rockies | — | Release |
| Jun 13, 2008 | Signed as free agent | Jorge Julio | — | Atlanta Braves | Free agent signing |
| Jun 13, 2008 | Signed as free agent | Fernando Seguignol | — | Detroit Tigers | Free agent signing |
| Jun 13, 2008 | Released | Adam Stern | Baltimore Orioles | — | Release |
| Jun 13, 2008 | Released | Reggie Taylor | Atlanta Braves | — | Release |
| Jun 13, 2008 | Released | Steve Trachsel | Baltimore Orioles | — | Release |
| Jun 13, 2008 | Trade | Henry Arias | Kansas City Royals | Cincinnati Reds | Trade |
| Jun 12, 2008 | Signed as free agent | Ben Broussard | — | Chicago Cubs | Free agent signing |
| Jun 12, 2008 | Signed as free agent | Jose Diaz | — | Texas Rangers | Free agent signing |
| Jun 12, 2008 | Released | Zack Segovia | Philadelphia Phillies | — | Release |
| Jun 12, 2008 | Released | Jeff Weaver | Milwaukee Brewers | — | Release |
| Jun 11, 2008 | Released | Armando Benitez | Toronto Blue Jays | — | Release |
| Jun 11, 2008 | Released | Steve Kline | Philadelphia Phillies | — | Release |
| Jun 10, 2008 | Released | Ben Broussard | New York Yankees | — | Release |
| Jun 10, 2008 | Released | Morgan Ensberg | New York Yankees | — | Release |
| Jun 10, 2008 | Signed as free agent | Brian Rogers | — | Detroit Tigers | Free agent signing |
| Jun 9, 2008 | Signed as free agent | John Halama | — | Cleveland Indians | Free agent signing |
| Jun 9, 2008 | Released | Randy Keisler | Chicago Cubs | — | Release |
| Jun 9, 2008 | Signed as free agent | Randy Keisler | — | Baltimore Orioles | Free agent signing |
| Jun 9, 2008 | Signed as free agent | Brian Lawrence | — | Atlanta Braves | Free agent signing |
| Jun 9, 2008 | Signed as free agent | Bret Prinz | — | Oakland Athletics | Free agent signing |
| Jun 9, 2008 | Signed as free agent | Dan Reichert | — | Cleveland Indians | Free agent signing |
| Jun 9, 2008 | Released | Victor Zambrano | Colorado Rockies | — | Release |
| Jun 7, 2008 | Released | Rob Bell | Chicago White Sox | — | Release |
| Jun 7, 2008 | Released | Rob Mackowiak | Washington Nationals | — | Release |
| Jun 7, 2008 | Signed as free agent | John Rodriguez | — | New York Mets | Free agent signing |
| Jun 7, 2008 | Released | Scott Williamson | Atlanta Braves | — | Release |
| Jun 6, 2008 | Released | Jose Cruz | Houston Astros | — | Release |
| Jun 6, 2008 | Trade | Unnamed | Los Angeles Dodgers | Kansas City Royals | $ |
| Jun 6, 2008 | Trade | Juan Rivera | Los Angeles Dodgers | Kansas City Royals | Trade |
| Jun 6, 2008 | Trade | Angel Berroa | Kansas City Royals | Los Angeles Dodgers | Trade |
| Jun 5, 2008 | Released | Matt Anderson | Chicago White Sox | — | Release |
| Jun 5, 2008 | Released | Jose Diaz | New York Mets | — | Release |
| Jun 5, 2008 | Released | Mike Gallo | Toronto Blue Jays | — | Release |
| Jun 5, 2008 | Released | Scott Hatteberg | Cincinnati Reds | — | Release |
| Jun 4, 2008 | Signed as free agent | Franklyn German | — | Pittsburgh Pirates | Free agent signing |
| Jun 4, 2008 | Signed as free agent | Esteban Loaiza | — | Chicago White Sox | Free agent signing |
| Jun 4, 2008 | Released | Brian Rogers | Pittsburgh Pirates | — | Release |
| Jun 3, 2008 | Released | Esteban Loaiza | Los Angeles Dodgers | — | Release |
| Jun 2, 2008 | Signed as free agent | Dave Gassner | — | Boston Red Sox | Free agent signing |
| Jun 2, 2008 | Signed as free agent | Raul Gonzalez | — | New York Mets | Free agent signing |
| Jun 2, 2008 | Released | John Rodriguez | Tampa Bay Rays | — | Release |
| Jun 2, 2008 | Signed | Enny Romero | — | Tampa Bay Rays | Amateur free agent signing |
| Jun 1, 2008 | Signed as free agent | Scott Munter | — | San Francisco Giants | Free agent signing |
| Jun 1, 2008 | Released | Shane Youman | Philadelphia Phillies | — | Release |
| May 31, 2008 | Signed as free agent | Ray King | — | Houston Astros | Free agent signing |
| May 31, 2008 | Released | Chin-hui Tsao | Kansas City Royals | — | Release |
| May 31, 2008 | Released | Joe Winkelsas | Chicago White Sox | — | Release |
| May 31, 2008 | Signed as free agent | Chris Woodward | — | Milwaukee Brewers | Free agent signing |
| May 30, 2008 | Signed as free agent | Chris Michalak | — | Florida Marlins | Free agent signing |
| May 30, 2008 | Signed as free agent | Todd Ritchie | — | Colorado Rockies | Free agent signing |
| May 29, 2008 | Signed as free agent | Brandon Knight | — | New York Mets | Free agent signing |
| May 29, 2008 | Signed as free agent | Danny Kolb | — | Toronto Blue Jays | Free agent signing |
| May 29, 2008 | Signed as free agent | Pokey Reese | — | Washington Nationals | Free agent signing |
| May 29, 2008 | Signed as free agent | Jorge Sosa | — | Houston Astros | Free agent signing |
| May 28, 2008 | Signed as free agent | Jason Dubois | — | Chicago Cubs | Free agent signing |
| May 28, 2008 | Signed as free agent | Adam Greenberg | — | Los Angeles Angels of Anaheim | Free agent signing |
| May 28, 2008 | Released | Jorge Julio | Cleveland Indians | — | Release |
| May 28, 2008 | Released | Scott Munter | Tampa Bay Rays | — | Release |
| May 28, 2008 | Signed as free agent | Danny Sandoval | — | Toronto Blue Jays | Free agent signing |
| May 28, 2008 | Signed as free agent | Scott Sauerbeck | — | Chicago White Sox | Free agent signing |
| May 28, 2008 | Signed as free agent | Steve Torrealba | — | Baltimore Orioles | Free agent signing |
| May 27, 2008 | Signed as free agent | Ben Broussard | — | New York Yankees | Free agent signing |
| May 27, 2008 | Released | Danny Sandoval | Cleveland Indians | — | Release |
| May 27, 2008 | Signed as free agent | Julian Tavarez | — | Milwaukee Brewers | Free agent signing |
| May 27, 2008 | Signed as free agent | Joe Valentine | — | Philadelphia Phillies | Free agent signing |
| May 27, 2008 | Trade | Cha-Seung Baek | Seattle Mariners | San Diego Padres | Trade |
| May 27, 2008 | Trade | Jared Wells | San Diego Padres | Seattle Mariners | Trade |
| May 26, 2008 | Released | Mike Johnston | San Diego Padres | — | Release |
| May 26, 2008 | Signed as free agent | Dustan Mohr | — | Colorado Rockies | Free agent signing |
| May 26, 2008 | Signed as free agent | Jorge Velandia | — | Cleveland Indians | Free agent signing |
| May 25, 2008 | Signed as free agent | Philip Barzilla | — | San Diego Padres | Free agent signing |
| May 25, 2008 | Signed as free agent | Todd Linden | — | Cleveland Indians | Free agent signing |
| May 25, 2008 | Released | Chris Michalak | Texas Rangers | — | Release |
| May 25, 2008 | Signed | Ender Inciarte | — | Arizona Diamondbacks | Amateur free agent signing |
| May 23, 2008 | Released | Steve Delabar | San Diego Padres | — | Release |
| May 23, 2008 | Released | Justin Lehr | Cincinnati Reds | — | Release |
| May 22, 2008 | Released | Julian Tavarez | Boston Red Sox | — | Release |
| May 21, 2008 | Signed as free agent | Horacio Ramirez | — | Kansas City Royals | Free agent signing |
| May 21, 2008 | Released | Jorge Sosa | New York Mets | — | Release |
| May 21, 2008 | Released | Jason Stanford | Cleveland Indians | — | Release |
| May 20, 2008 | Released | Bobby Cramer | Oakland Athletics | — | Release |
| May 20, 2008 | Released | Ray King | Chicago White Sox | — | Release |
| May 20, 2008 | Released | Todd Linden | Oakland Athletics | — | Release |
| May 20, 2008 | Signed | Jonathan Villar | — | Philadelphia Phillies | Amateur free agent signing |
| May 19, 2008 | Signed as free agent | Jacque Jones | — | Florida Marlins | Free agent signing |
| May 19, 2008 | Signed as free agent | Abraham Nunez | — | New York Mets | Free agent signing |
| May 18, 2008 | Released | Jason Dubois | Washington Nationals | — | Release |
| May 17, 2008 | Signed as free agent | George Lombard | — | Florida Marlins | Free agent signing |
| May 17, 2008 | Released | Abraham Nunez | Milwaukee Brewers | — | Release |
| May 17, 2008 | Signed as free agent | Eric Reed | — | New York Mets | Free agent signing |
| May 16, 2008 | Released | Ben Broussard | Texas Rangers | — | Release |
| May 16, 2008 | Signed as free agent | Glendon Rusch | — | Colorado Rockies | Free agent signing |
| May 15, 2008 | Released | Philip Barzilla | Seattle Mariners | — | Release |
| May 14, 2008 | Signed as free agent | Jim Edmonds | — | Chicago Cubs | Free agent signing |
| May 13, 2008 | Released | Jacque Jones | Detroit Tigers | — | Release |
| May 12, 2008 | Released | Abe Alvarez | Boston Red Sox | — | Release |
| May 12, 2008 | Released | Troy Cate | Oakland Athletics | — | Release |
| May 12, 2008 | Released | Josh Hall | Washington Nationals | — | Release |
| May 12, 2008 | Released | Stu Pomeranz | St. Louis Cardinals | — | Release |
| May 10, 2008 | Signed as free agent | Enrique Cruz | — | Atlanta Braves | Free agent signing |
| May 10, 2008 | Released | Ken Huckaby | Kansas City Royals | — | Release |
| May 9, 2008 | Released | Jim Edmonds | San Diego Padres | — | Release |
| May 9, 2008 | Signed as free agent | Brad Wilkerson | — | Toronto Blue Jays | Free agent signing |
| May 8, 2008 | Released | Kevin Beirne | Philadelphia Phillies | — | Release |
| May 8, 2008 | Signed as free agent | Victor Diaz | — | Seattle Mariners | Free agent signing |
| May 8, 2008 | Signed as free agent | Aaron Fultz | — | Colorado Rockies | Free agent signing |
| May 8, 2008 | Signed as free agent | Ryan O'Malley | — | Chicago White Sox | Free agent signing |
| May 8, 2008 | Signed as free agent | Shawn Wooten | — | San Diego Padres | Free agent signing |
| May 7, 2008 | Signed as free agent | Colter Bean | — | Tampa Bay Rays | Free agent signing |
| May 7, 2008 | Trade | Travis Dawkins | Philadelphia Phillies | Chicago White Sox | Trade |
| May 7, 2008 | Trade | Mike Rouse | Chicago White Sox | Philadelphia Phillies | Trade |
| May 6, 2008 | Released | Zach Day | Minnesota Twins | — | Release |
| May 6, 2008 | Released | Ben Johnson | New York Mets | — | Release |
| May 6, 2008 | Signed as free agent | Bronson Sardinha | — | Cleveland Indians | Free agent signing |
| May 6, 2008 | Released | Scott Sauerbeck | Cincinnati Reds | — | Release |
| May 5, 2008 | Signed as free agent | Hector Carrasco | — | Chicago Cubs | Free agent signing |
| May 5, 2008 | Signed as free agent | Ray King | — | Chicago White Sox | Free agent signing |
| May 5, 2008 | Signed as free agent | Eli Whiteside | — | San Francisco Giants | Free agent signing |
| May 5, 2008 | Trade | Greg Norton | Seattle Mariners | Atlanta Braves | Trade |
| May 4, 2008 | Signed as free agent | Juan Castro | — | Colorado Rockies | Free agent signing |
| May 4, 2008 | Signed as free agent | Juan Mateo | — | Pittsburgh Pirates | Free agent signing |
| May 3, 2008 | Released | Jesse Garcia | Chicago Cubs | — | Release |
| May 3, 2008 | Signed as free agent | Les Walrond | — | Philadelphia Phillies | Free agent signing |
| May 3, 2008 | Released | Shawn Wooten | New York Mets | — | Release |
| May 2, 2008 | Released | Juan Castro | Cincinnati Reds | — | Release |
| May 2, 2008 | Released | Eric Cyr | Seattle Mariners | — | Release |
| May 2, 2008 | Released | Victor Diaz | Houston Astros | — | Release |
| May 2, 2008 | Signed as free agent | Reid Gorecki | — | Atlanta Braves | Free agent signing |
| May 2, 2008 | Released | Lance Niekro | Houston Astros | — | Release |
| May 1, 2008 | Released | Tony Batista | Washington Nationals | — | Release |
| May 1, 2008 | Signed as free agent | JD Closser | — | New York Yankees | Free agent signing |
| May 1, 2008 | Released | Vic Darensbourg | Philadelphia Phillies | — | Release |
| May 1, 2008 | Released | Chris Woodward | Philadelphia Phillies | — | Release |
| Apr 30, 2008 | Released | Mike Maroth | Kansas City Royals | — | Release |
| Apr 30, 2008 | Signed as free agent | Val Pascucci | — | New York Mets | Free agent signing |
| Apr 30, 2008 | Released | Eli Whiteside | Minnesota Twins | — | Release |
| Apr 30, 2008 | Released | Brad Wilkerson | Seattle Mariners | — | Release |
| Apr 30, 2008 | Trade | Jorge De La Rosa | Kansas City Royals | Colorado Rockies | Trade |
| Apr 30, 2008 | Trade | Jason Grilli | Detroit Tigers | Colorado Rockies | Trade |
| Apr 30, 2008 | Trade | Zach Simons | Colorado Rockies | Detroit Tigers | Trade |
| Apr 28, 2008 | Signed as free agent | Mark Bellhorn | — | Los Angeles Dodgers | Free agent signing |
| Apr 28, 2008 | Released | Val Pascucci | Philadelphia Phillies | — | Release |
| Apr 27, 2008 | Released | Matt Morris | Pittsburgh Pirates | — | Release |
| Apr 27, 2008 | Released | Les Walrond | Chicago Cubs | — | Release |
| Apr 26, 2008 | Released | Danny Kolb | Boston Red Sox | — | Release |
| Apr 25, 2008 | Signed as free agent | Brian Gordon | — | Texas Rangers | Free agent signing |
| Apr 25, 2008 | Released | George Lombard | Los Angeles Dodgers | — | Release |
| Apr 25, 2008 | Released | Adam Melhuse | Texas Rangers | — | Release |
| Apr 25, 2008 | Released | Hideo Nomo | Kansas City Royals | — | Release |
| Apr 25, 2008 | Signed as free agent | Tim Spooneybarger | — | Baltimore Orioles | Free agent signing |
| Apr 25, 2008 | Signed as free agent | Jason Stanford | — | Cleveland Indians | Free agent signing |
| Apr 25, 2008 | Signed as free agent | Scott Williamson | — | Atlanta Braves | Free agent signing |
| Apr 24, 2008 | Released | Mike Myers | Los Angeles Dodgers | — | Release |
| Apr 24, 2008 | Signed as free agent | Frank Thomas | — | Oakland Athletics | Free agent signing |
| Apr 24, 2008 | Trade | Sean Smith | Cleveland Indians | Colorado Rockies | Trade |
| Apr 22, 2008 | Signed as free agent | Josh Labandeira | — | Tampa Bay Rays | Free agent signing |
| Apr 22, 2008 | Signed as free agent | Rich Thompson | — | Philadelphia Phillies | Free agent signing |
| Apr 22, 2008 | Trade | Gabe Gross | Milwaukee Brewers | Tampa Bay Rays | Trade |
| Apr 22, 2008 | Trade | Josh Butler | Tampa Bay Rays | Milwaukee Brewers | Trade |
| Apr 21, 2008 | Signed as free agent | Eude Brito | — | New York Mets | Free agent signing |
| Apr 21, 2008 | Released | Henry Mateo | Detroit Tigers | — | Release |
| Apr 21, 2008 | Released | Jason Stanford | Washington Nationals | — | Release |
| Apr 20, 2008 | Released | Frank Thomas | Toronto Blue Jays | — | Release |
| Apr 19, 2008 | Signed as free agent | Jason Perry | — | Atlanta Braves | Free agent signing |
| Apr 18, 2008 | Released | Pete LaForest | Philadelphia Phillies | — | Release |
| Apr 18, 2008 | Released | Bronson Sardinha | Seattle Mariners | — | Release |
| Apr 17, 2008 | Released | Eude Brito | Washington Nationals | — | Release |
| Apr 17, 2008 | Signed as free agent | Charlton Jimerson | — | Seattle Mariners | Free agent signing |
| Apr 16, 2008 | Signed as free agent | Jeff Weaver | — | Milwaukee Brewers | Free agent signing |
| Apr 14, 2008 | Released | Ricky Stone | Cincinnati Reds | — | Release |
| Apr 14, 2008 | Signed as free agent | Steve Woodard | — | Florida Marlins | Free agent signing |
| Apr 12, 2008 | Released | Scott Spiezio | Atlanta Braves | — | Release |
| Apr 11, 2008 | Signed as free agent | Rob Bell | — | Chicago White Sox | Free agent signing |
| Apr 11, 2008 | Signed as free agent | Sal Fasano | — | Atlanta Braves | Free agent signing |
| Apr 11, 2008 | Released | Aaron Fultz | Detroit Tigers | — | Release |
| Apr 11, 2008 | Released | Brian Gordon | Houston Astros | — | Release |
| Apr 11, 2008 | Signed as free agent | Steve Kline | — | Philadelphia Phillies | Free agent signing |
| Apr 11, 2008 | Released | Dave Krynzel | Arizona Diamondbacks | — | Release |
| Apr 11, 2008 | Signed as free agent | Steve Schmoll | — | Washington Nationals | Free agent signing |
| Apr 11, 2008 | Signed as free agent | Claudio Vargas | — | New York Mets | Free agent signing |
| Apr 11, 2008 | Signed | Ramon Cabrera | — | Pittsburgh Pirates | Amateur free agent signing |
| Apr 10, 2008 | Released | JD Closser | Chicago Cubs | — | Release |
| Apr 10, 2008 | Released | Eric Reed | Florida Marlins | — | Release |
| Apr 10, 2008 | Released | Rich Thompson | Boston Red Sox | — | Release |
| Apr 9, 2008 | Signed as free agent | Josh Sharpless | — | San Francisco Giants | Free agent signing |
| Apr 8, 2008 | Signed as free agent | Casey Fossum | — | Detroit Tigers | Free agent signing |
| Apr 8, 2008 | Trade | Unnamed | Boston Red Sox | Los Angeles Dodgers | $ |
| Apr 8, 2008 | Trade | Christian Lara | Boston Red Sox | Los Angeles Dodgers | Trade |
| Apr 8, 2008 | Trade | Eric Hull | Los Angeles Dodgers | Boston Red Sox | Trade |
| Apr 7, 2008 | Signed as free agent | Josh Paul | — | Houston Astros | Free agent signing |
| Apr 7, 2008 | Signed as free agent | Craig Wilson | — | Pittsburgh Pirates | Free agent signing |
| Apr 7, 2008 | Trade | Jon Coutlangus | Cincinnati Reds | Arizona Diamondbacks | Trade |
| Apr 7, 2008 | Trade | Danny Perales | Arizona Diamondbacks | Cincinnati Reds | Trade |
| Apr 5, 2008 | Released | Steve Kline | San Francisco Giants | — | Release |
| Apr 5, 2008 | Signed as free agent | Scott Spiezio | — | Atlanta Braves | Free agent signing |
| Apr 4, 2008 | Released | Colter Bean | Atlanta Braves | — | Release |
| Apr 4, 2008 | Signed as free agent | Jeff DaVanon | — | Chicago White Sox | Free agent signing |
| Apr 4, 2008 | Signed as free agent | Jesse Garcia | — | Chicago Cubs | Free agent signing |
| Apr 3, 2008 | Signed as free agent | Tim Byrdak | — | Houston Astros | Free agent signing |
| Apr 3, 2008 | Signed as free agent | Alex Cintron | — | Baltimore Orioles | Free agent signing |
| Apr 3, 2008 | Signed as free agent | Chris Stewart | — | New York Yankees | Free agent signing |
| Apr 2, 2008 | Signed as free agent | Randy Keisler | — | Chicago Cubs | Free agent signing |
| Apr 2, 2008 | Released | Fernando Seguignol | Colorado Rockies | — | Release |
| Apr 1, 2008 | Signed as free agent | Andy Cavazos | — | Chicago Cubs | Free agent signing |
| Apr 1, 2008 | Signed as free agent | Aaron Fultz | — | Detroit Tigers | Free agent signing |
| Apr 1, 2008 | Signed as free agent | Vladimir Nunez | — | Atlanta Braves | Free agent signing |
| Mar 31, 2008 | Signed as free agent | Mike Burns | — | Chicago Cubs | Free agent signing |
| Mar 31, 2008 | Signed as free agent | Wilkin Ruan | — | Los Angeles Dodgers | Free agent signing |
| Mar 31, 2008 | Signed as free agent | Rudy Seanez | — | Philadelphia Phillies | Free agent signing |
| Mar 31, 2008 | Signed as free agent | Jorge Velandia | — | Toronto Blue Jays | Free agent signing |
| Mar 30, 2008 | Signed as free agent | Danny Graves | — | Minnesota Twins | Free agent signing |
| Mar 30, 2008 | Signed as free agent | Chris Michalak | — | Texas Rangers | Free agent signing |
| Mar 30, 2008 | Released | Wilkin Ruan | Los Angeles Dodgers | — | Release |
| Mar 30, 2008 | Released | Alfredo Simon | Los Angeles Dodgers | — | Release |
| Mar 30, 2008 | Signed | Manny Banuelos | — | New York Yankees | Amateur free agent signing |
| Mar 29, 2008 | Released | Mike Burns | Pittsburgh Pirates | — | Release |
| Mar 29, 2008 | Released | Enrique Cruz | New York Mets | — | Release |
| Mar 29, 2008 | Released | Jay Gibbons | Baltimore Orioles | — | Release |
| Mar 29, 2008 | Signed as free agent | Ben Hendrickson | — | Tampa Bay Rays | Free agent signing |
| Mar 29, 2008 | Signed as free agent | Ray Olmedo | — | Washington Nationals | Free agent signing |
| Mar 29, 2008 | Released | Ryan O'Malley | Chicago Cubs | — | Release |
| Mar 29, 2008 | Released | Josh Paul | Tampa Bay Rays | — | Release |
| Mar 29, 2008 | Released | Steve Schmoll | New York Mets | — | Release |
| Mar 29, 2008 | Released | Jorge Velandia | Pittsburgh Pirates | — | Release |
| Mar 29, 2008 | Released | Woody Williams | Houston Astros | — | Release |
| Mar 29, 2008 | Trade | R. A. Dickey | Minnesota Twins | Seattle Mariners | Trade |
| Mar 29, 2008 | Trade | Jair Fernandez | Seattle Mariners | Minnesota Twins | Trade |
| Mar 28, 2008 | Signed as free agent | Jason Davis | — | Pittsburgh Pirates | Free agent signing |
| Mar 28, 2008 | Released | Dane De La Rosa | Milwaukee Brewers | — | Release |
| Mar 28, 2008 | Released | Aaron Fultz | Cleveland Indians | — | Release |
| Mar 28, 2008 | Released | Adam Greenberg | Kansas City Royals | — | Release |
| Mar 28, 2008 | Released | Ben Hendrickson | Kansas City Royals | — | Release |
| Mar 28, 2008 | Signed as free agent | Ben Howard | — | Milwaukee Brewers | Free agent signing |
| Mar 28, 2008 | Released | Randy Keisler | Minnesota Twins | — | Release |
| Mar 28, 2008 | Released | Kevin Mahar | Texas Rangers | — | Release |
| Mar 28, 2008 | Released | Val Majewski | Baltimore Orioles | — | Release |
| Mar 28, 2008 | Released | Chris Michalak | Cincinnati Reds | — | Release |
| Mar 28, 2008 | Released | Ray Olmedo | Philadelphia Phillies | — | Release |
| Mar 28, 2008 | Released | Jason Perry | Detroit Tigers | — | Release |
| Mar 28, 2008 | Released | Josh Sharpless | Pittsburgh Pirates | — | Release |
| Mar 28, 2008 | Released | Mike Stanton | Cincinnati Reds | — | Release |
| Mar 28, 2008 | Released | Steve Torrealba | Boston Red Sox | — | Release |
| Mar 28, 2008 | Signed as free agent | Chris Woodward | — | Philadelphia Phillies | Free agent signing |
| Mar 28, 2008 | Trade | Dustin Nippert | Arizona Diamondbacks | Texas Rangers | Trade |
| Mar 28, 2008 | Trade | Jose Marte | Texas Rangers | Arizona Diamondbacks | Trade |
| Mar 28, 2008 | Released | Scott Rice | Los Angeles Dodgers | — | Release |
| Mar 27, 2008 | Signed as free agent | Eric Cyr | — | Seattle Mariners | Free agent signing |
| Mar 27, 2008 | Released | Jason Davis | Texas Rangers | — | Release |
| Mar 27, 2008 | Released | Elmer Dessens | Pittsburgh Pirates | — | Release |
| Mar 27, 2008 | Released | Ryan Drese | Atlanta Braves | — | Release |
| Mar 27, 2008 | Released | Josh Labandeira | San Francisco Giants | — | Release |
| Mar 27, 2008 | Released | Antonio Perez | Washington Nationals | — | Release |
| Mar 27, 2008 | Released | Chris Stewart | Texas Rangers | — | Release |
| Mar 26, 2008 | Released | Tim Byrdak | Detroit Tigers | — | Release |
| Mar 26, 2008 | Released | Hector Carrasco | Pittsburgh Pirates | — | Release |
| Mar 26, 2008 | Released | Alex Cintron | Chicago Cubs | — | Release |
| Mar 26, 2008 | Signed as free agent | Humberto Cota | — | Colorado Rockies | Free agent signing |
| Mar 26, 2008 | Released | Marcus Giles | Colorado Rockies | — | Release |
| Mar 26, 2008 | Released | Brian Lawrence | Kansas City Royals | — | Release |
| Mar 26, 2008 | Released | Rudy Seanez | Los Angeles Dodgers | — | Release |
| Mar 26, 2008 | Released | Chris Woodward | New York Yankees | — | Release |
| Mar 26, 2008 | Trade | Tyler Yates | Atlanta Braves | Pittsburgh Pirates | Trade |
| Mar 26, 2008 | Trade | Todd Redmond | Pittsburgh Pirates | Atlanta Braves | Trade |
| Mar 26, 2008 | Trade | Ramon Ramirez | Colorado Rockies | Kansas City Royals | Trade |
| Mar 25, 2008 | Released | Sal Fasano | Toronto Blue Jays | — | Release |
| Mar 25, 2008 | Released | Reid Gorecki | St. Louis Cardinals | — | Release |
| Mar 25, 2008 | Released | Ben Howard | Boston Red Sox | — | Release |
| Mar 25, 2008 | Signed as free agent | Reed Johnson | — | Chicago Cubs | Free agent signing |
| Mar 25, 2008 | Released | Claudio Vargas | Milwaukee Brewers | — | Release |
| Mar 25, 2008 | Signed as free agent | Arnold Leon | — | Oakland Athletics | Free agent signing with first major-league team |
| Mar 24, 2008 | Released | Eric Cyr | Texas Rangers | — | Release |
| Mar 24, 2008 | Released | Ramon Nivar | San Diego Padres | — | Release |
| Mar 24, 2008 | Released | Mike Rose | Colorado Rockies | — | Release |
| Mar 23, 2008 | Released | Reed Johnson | Toronto Blue Jays | — | Release |
| Mar 22, 2008 | Signed as free agent | Tony Armas | — | New York Mets | Free agent signing |
| Mar 22, 2008 | Released | Rob Bell | Washington Nationals | — | Release |
| Mar 22, 2008 | Released | Jeff DaVanon | San Diego Padres | — | Release |
| Mar 22, 2008 | Released | Dave Gassner | Cincinnati Reds | — | Release |
| Mar 22, 2008 | Released | Brad Halsey | Oakland Athletics | — | Release |
| Mar 22, 2008 | Released | Franklin Nunez | Milwaukee Brewers | — | Release |
| Mar 21, 2008 | Released | Andy Cavazos | New York Mets | — | Release |
| Mar 20, 2008 | Signed | Audry Perez | — | St. Louis Cardinals | Amateur free agent signing |
| Mar 19, 2008 | Trade | Brad Salmon | Cincinnati Reds | Kansas City Royals | Trade |
| Mar 18, 2008 | Released | Humberto Cota | Washington Nationals | — | Release |
| Mar 18, 2008 | Signed as free agent | Steve Green | — | Philadelphia Phillies | Free agent signing |
| Mar 13, 2008 | Signed as free agent | Armando Benitez | — | Toronto Blue Jays | Free agent signing |
| Mar 13, 2008 | Signed as free agent | Kyle Lohse | — | St. Louis Cardinals | Free agent signing |
| Mar 13, 2008 | Signed as free agent | Fernando Tatis | — | New York Mets | Free agent signing |
| Mar 12, 2008 | Signed as free agent | Chad Moeller | — | New York Yankees | Free agent signing |
| Mar 12, 2008 | Released | Horacio Ramirez | Seattle Mariners | — | Release |
| Mar 12, 2008 | Signed | Christian Bethancourt | — | Atlanta Braves | Amateur free agent signing |
| Mar 12, 2008 | Signed | Carlos Contreras | — | Cincinnati Reds | Amateur free agent signing |
| Mar 11, 2008 | Released | Shingo Takatsu | Chicago Cubs | — | Release |
| Mar 10, 2008 | Signed as free agent | Tony Batista | — | Washington Nationals | Free agent signing |
| Mar 10, 2008 | Signed as free agent | Enrique Cruz | — | New York Mets | Free agent signing |
| Mar 10, 2008 | Released | Tom Martin | Los Angeles Dodgers | — | Release |
| Mar 10, 2008 | Released | Chad Moeller | Washington Nationals | — | Release |
| Mar 10, 2008 | Signed as free agent | Sidney Ponson | — | Texas Rangers | Free agent signing |
| Mar 10, 2008 | Signed as free agent | Jose Quintana | — | New York Yankees | Free agent signing |
| Mar 9, 2008 | Released | Jorge Piedra | Florida Marlins | — | Release |
| Mar 8, 2008 | Released | Bubba Crosby | Seattle Mariners | — | Release |
| Mar 8, 2008 | Signed as free agent | Runelvys Hernandez | — | Houston Astros | Free agent signing |
| Mar 8, 2008 | Signed as free agent | Denny Stark | — | Seattle Mariners | Free agent signing |
| Mar 7, 2008 | Signed as free agent | Blaine Neal | — | Detroit Tigers | Free agent signing |
| Mar 5, 2008 | Signed | Edwar Cabrera | — | Colorado Rockies | Amateur free agent signing |
| Mar 5, 2008 | Signed as free agent | Jerry Hairston | — | Cincinnati Reds | Free agent signing |
| Mar 5, 2008 | Signed as free agent | Ryan O'Malley | — | Chicago Cubs | Free agent signing |
| Mar 5, 2008 | Signed as free agent | Corey Patterson | — | Cincinnati Reds | Free agent signing |
| Mar 5, 2008 | Signed as free agent | Fernando Seguignol | — | Colorado Rockies | Free agent signing |
| Mar 5, 2008 | Released | Scott Williamson | San Francisco Giants | — | Release |
| Mar 5, 2008 | Signed as free agent | Dewayne Wise | — | Chicago White Sox | Free agent signing |
| Mar 4, 2008 | Signed as free agent | John Axford | — | Milwaukee Brewers | Free agent signing |
| Mar 4, 2008 | Signed | Melvin Mercedes | — | Detroit Tigers | Amateur free agent signing |
| Mar 3, 2008 | Signed as free agent | Jason Kershner | — | Philadelphia Phillies | Free agent signing |
| Mar 2, 2008 | Signed as free agent | Scott Rice | — | Los Angeles Dodgers | Free agent signing |
| Feb 29, 2008 | Signed as free agent | Ramon Martinez | — | Los Angeles Dodgers | Free agent signing |
| Feb 27, 2008 | Signed as free agent | Miguel Asencio | — | Boston Red Sox | Free agent signing |
| Feb 27, 2008 | Released | Scott Spiezio | St. Louis Cardinals | — | Release |
| Feb 26, 2008 | Signed as free agent | Matt Anderson | — | Chicago White Sox | Free agent signing |
| Feb 25, 2008 | Signed as free agent | Mike Kinkade | — | Seattle Mariners | Free agent signing |
| Feb 25, 2008 | Signed as free agent | Shannon Stewart | — | Toronto Blue Jays | Free agent signing |
| Feb 24, 2008 | Signed as free agent | Bartolo Colon | — | Boston Red Sox | Free agent signing |
| Feb 23, 2008 | Signed as free agent | Odalis Perez | — | Washington Nationals | Free agent signing |
| Feb 22, 2008 | Signed as free agent | Brady Clark | — | New York Mets | Free agent signing |
| Feb 22, 2008 | Released | Craig Wilson | Cincinnati Reds | — | Release |
| Feb 21, 2008 | Signed as free agent | Alex Cintron | — | Chicago Cubs | Free agent signing |
| Feb 21, 2008 | Signed as free agent | Josh Fogg | — | Cincinnati Reds | Free agent signing |
| Feb 21, 2008 | Signed as free agent | Tomo Ohka | — | Chicago White Sox | Free agent signing |
| Feb 21, 2008 | Signed as free agent | Jason Tyner | — | Cleveland Indians | Free agent signing |
| Feb 20, 2008 | Signed as free agent | Kris Benson | — | Philadelphia Phillies | Free agent signing |
| Feb 20, 2008 | Signed as free agent | Russell Branyan | — | Milwaukee Brewers | Free agent signing |
| Feb 20, 2008 | Signed as free agent | Nate Bump | — | San Francisco Giants | Free agent signing |
| Feb 20, 2008 | Signed as free agent | Shawn Chacon | — | Houston Astros | Free agent signing |
| Feb 20, 2008 | Signed as free agent | Byung-Hyun Kim | — | Pittsburgh Pirates | Free agent signing |
| Feb 20, 2008 | Signed as free agent | Josh Labandeira | — | San Francisco Giants | Free agent signing |
| Feb 20, 2008 | Signed as free agent | Trot Nixon | — | Arizona Diamondbacks | Free agent signing |
| Feb 19, 2008 | Signed as free agent | Bret Boone | — | Washington Nationals | Free agent signing |
| Feb 19, 2008 | Signed as free agent | Bubba Crosby | — | Seattle Mariners | Free agent signing |
| Feb 19, 2008 | Signed as free agent | Ron Villone | — | St. Louis Cardinals | Free agent signing |
| Feb 18, 2008 | Signed as free agent | Juan Padilla | — | New York Mets | Free agent signing |
| Feb 18, 2008 | Signed as free agent | Jose Valentin | — | New York Mets | Free agent signing |
| Feb 17, 2008 | Signed as free agent | Valerio De Los Santos | — | Colorado Rockies | Free agent signing |
| Feb 17, 2008 | Signed as free agent | Mike Maroth | — | Kansas City Royals | Free agent signing |
| Feb 17, 2008 | Signed as free agent | Scott Podsednik | — | Colorado Rockies | Free agent signing |
| Feb 16, 2008 | Signed as free agent | Nook Logan | — | Los Angeles Dodgers | Free agent signing |
| Feb 16, 2008 | Signed as free agent | Kevin Mench | — | Texas Rangers | Free agent signing |
| Feb 16, 2008 | Signed as free agent | Damian Moss | — | Atlanta Braves | Free agent signing |
| Feb 15, 2008 | Signed as free agent | Matt LeCroy | — | Oakland Athletics | Free agent signing |
| Feb 15, 2008 | Signed as free agent | Greg Norton | — | Seattle Mariners | Free agent signing |
| Feb 15, 2008 | Signed as free agent | John Parrish | — | Toronto Blue Jays | Free agent signing |
| Feb 15, 2008 | Signed as free agent | Chris Spurling | — | Milwaukee Brewers | Free agent signing |
| Feb 15, 2008 | Signed | Marcell Ozuna | — | Florida Marlins | Amateur free agent signing |
| Feb 14, 2008 | Signed as free agent | Ben Johnson | — | New York Mets | Free agent signing |
| Feb 14, 2008 | Signed as free agent | Kent Mercker | — | Cincinnati Reds | Free agent signing |
| Feb 14, 2008 | Signed as free agent | David Newhan | — | Houston Astros | Free agent signing |
| Feb 14, 2008 | Signed as free agent | Ricardo Rincon | — | New York Mets | Free agent signing |
| Feb 12, 2008 | Signed as free agent | Chris Aguila | — | New York Mets | Free agent signing |
| Feb 12, 2008 | Signed as free agent | Livan Hernandez | — | Minnesota Twins | Free agent signing |
| Feb 12, 2008 | Signed as free agent | Olmedo Saenz | — | New York Mets | Free agent signing |
| Feb 12, 2008 | Signed as free agent | Mark Sweeney | — | Los Angeles Dodgers | Free agent signing |
| Feb 11, 2008 | Signed as free agent | Tony Clark | — | San Diego Padres | Free agent signing |
| Feb 11, 2008 | Signed as free agent | Dave Gassner | — | Cincinnati Reds | Free agent signing |
| Feb 11, 2008 | Signed as free agent | Doug Mientkiewicz | — | Pittsburgh Pirates | Free agent signing |
| Feb 11, 2008 | Signed as free agent | Mike Sweeney | — | Oakland Athletics | Free agent signing |
| Feb 11, 2008 | Signed as free agent | Steve Trachsel | — | Baltimore Orioles | Free agent signing |
| Feb 11, 2008 | Signed as free agent | Scott Williamson | — | San Francisco Giants | Free agent signing |
| Feb 9, 2008 | Signed as free agent | Jose Santiago | — | New York Mets | Free agent signing |
| Feb 8, 2008 | Signed as free agent | Alberto Castillo | — | Houston Astros | Free agent signing |
| Feb 8, 2008 | Signed as free agent | Scott Elarton | — | Cleveland Indians | Free agent signing |
| Feb 8, 2008 | Signed as free agent | Keith Foulke | — | Oakland Athletics | Free agent signing |
| Feb 8, 2008 | Signed as free agent | Jeff Fulchino | — | Kansas City Royals | Free agent signing |
| Feb 8, 2008 | Signed as free agent | Jesse Garcia | — | Houston Astros | Free agent signing |
| Feb 8, 2008 | Signed as free agent | Bobby Kielty | — | Boston Red Sox | Free agent signing |
| Feb 8, 2008 | Signed as free agent | Julio Mateo | — | San Francisco Giants | Free agent signing |
| Feb 8, 2008 | Signed as free agent | Craig Wilson | — | Cincinnati Reds | Free agent signing |
| Feb 8, 2008 | Signed as free agent | Victor Zambrano | — | Colorado Rockies | Free agent signing |
| Feb 8, 2008 | Trade | Erik Bedard | Baltimore Orioles | Seattle Mariners | Trade |
| Feb 8, 2008 | Trade | Adam Jones | Seattle Mariners | Baltimore Orioles | Trade |
| Feb 8, 2008 | Trade | George Sherrill | Seattle Mariners | Baltimore Orioles | Trade |
| Feb 8, 2008 | Trade | Tony Butler | Seattle Mariners | Baltimore Orioles | Trade |
| Feb 8, 2008 | Trade | Chris Tillman | Seattle Mariners | Baltimore Orioles | Trade |
| Feb 8, 2008 | Trade | Kam Mickolio | Seattle Mariners | Baltimore Orioles | Trade |
| Feb 7, 2008 | Signed as free agent | Luis Maza | — | Los Angeles Dodgers | Free agent signing |
| Feb 6, 2008 | Signed as free agent | Brendan Donnelly | — | Cleveland Indians | Free agent signing |
| Feb 6, 2008 | Signed as free agent | Nelson Figueroa | — | New York Mets | Free agent signing |
| Feb 6, 2008 | Signed as free agent | Eric Hinske | — | Tampa Bay Rays | Free agent signing |
| Feb 6, 2008 | Signed as free agent | Jason Johnson | — | Los Angeles Dodgers | Free agent signing |
| Feb 6, 2008 | Signed as free agent | Trever Miller | — | Tampa Bay Rays | Free agent signing |
| Feb 5, 2008 | Signed as free agent | Mike Lincoln | — | Cincinnati Reds | Free agent signing |
| Feb 5, 2008 | Signed as free agent | Junior Spivey | — | Boston Red Sox | Free agent signing |
| Feb 5, 2008 | Trade | Armando Galarraga | Texas Rangers | Detroit Tigers | Trade |
| Feb 5, 2008 | Trade | Mike Hernandez | Detroit Tigers | Texas Rangers | Trade |
| Feb 4, 2008 | Signed as free agent | Rudy Seanez | — | Los Angeles Dodgers | Free agent signing |
| Feb 4, 2008 | Signed as free agent | Steve Torrealba | — | Boston Red Sox | Free agent signing |
| Feb 3, 2008 | Signed as free agent | Mike Myers | — | Los Angeles Dodgers | Free agent signing |
| Feb 2, 2008 | Trade | Johan Santana | Minnesota Twins | New York Mets | Trade |
| Feb 2, 2008 | Trade | Carlos Gomez | New York Mets | Minnesota Twins | Trade |
| Feb 2, 2008 | Trade | Philip Humber | New York Mets | Minnesota Twins | Trade |
| Feb 2, 2008 | Trade | Deolis Guerra | New York Mets | Minnesota Twins | Trade |
| Feb 2, 2008 | Trade | Kevin Mulvey | New York Mets | Minnesota Twins | Trade |
| Feb 1, 2008 | Signed as free agent | Alfredo Aceves | — | New York Yankees | Free agent signing |
| Feb 1, 2008 | Signed as free agent | Steve Andrade | — | Tampa Bay Rays | Free agent signing |
| Feb 1, 2008 | Signed as free agent | Paul Bako | — | Cincinnati Reds | Free agent signing |
| Feb 1, 2008 | Signed as free agent | Brian Buchanan | — | Kansas City Royals | Free agent signing |
| Feb 1, 2008 | Signed as free agent | Sean Casey | — | Boston Red Sox | Free agent signing |
| Feb 1, 2008 | Signed as free agent | Alberto Castillo | — | Baltimore Orioles | Free agent signing |
| Feb 1, 2008 | Signed as free agent | Andy Gonzalez | — | Cleveland Indians | Free agent signing |
| Feb 1, 2008 | Signed as free agent | Scott Sauerbeck | — | Cincinnati Reds | Free agent signing |
| Feb 1, 2008 | Signed as free agent | Esteban Yan | — | Baltimore Orioles | Free agent signing |
| Feb 1, 2008 | Signed as free agent | Brian Anderson | — | Tampa Bay Rays | Free agent signing |
| Jan 31, 2008 | Signed as free agent | Ezequiel Astacio | — | Cincinnati Reds | Free agent signing |
| Jan 31, 2008 | Signed as free agent | Morgan Ensberg | — | New York Yankees | Free agent signing |
| Jan 31, 2008 | Signed as free agent | Mike Gallo | — | Toronto Blue Jays | Free agent signing |
| Jan 31, 2008 | Released | Tony Giarratano | Detroit Tigers | — | Release |
| Jan 31, 2008 | Signed as free agent | Luis Gonzalez | — | Florida Marlins | Free agent signing |
| Jan 31, 2008 | Signed as free agent | Chris Heintz | — | Baltimore Orioles | Free agent signing |
| Jan 31, 2008 | Signed as free agent | Jorge Julio | — | Cleveland Indians | Free agent signing |
| Jan 31, 2008 | Signed as free agent | Dallas McPherson | — | Florida Marlins | Free agent signing |
| Jan 31, 2008 | Signed as free agent | Brian Moehler | — | Houston Astros | Free agent signing |
| Jan 31, 2008 | Signed as free agent | Brad Wilkerson | — | Seattle Mariners | Free agent signing |
| Jan 30, 2008 | Signed as free agent | Trey Hodges | — | Texas Rangers | Free agent signing |
| Jan 30, 2008 | Signed | Rafael Ortega | — | Colorado Rockies | Amateur free agent signing |
| Jan 30, 2008 | Signed as free agent | Josh Paul | — | Tampa Bay Rays | Free agent signing |
| Jan 29, 2008 | Signed as free agent | Johnny Estrada | — | Washington Nationals | Free agent signing |
| Jan 29, 2008 | Signed as free agent | Kevin Gryboski | — | San Francisco Giants | Free agent signing |
| Jan 28, 2008 | Signed as free agent | Pedro Feliz | — | Philadelphia Phillies | Free agent signing |
| Jan 28, 2008 | Trade | David Aardsma | Chicago White Sox | Boston Red Sox | Trade |
| Jan 28, 2008 | Trade | Willy Mota | Boston Red Sox | Chicago White Sox | Trade |
| Jan 28, 2008 | Trade | Miguel Socolovich | Boston Red Sox | Chicago White Sox | Trade |
| Jan 27, 2008 | Signed as free agent | Jody Gerut | — | San Diego Padres | Free agent signing |
| Jan 27, 2008 | Signed as free agent | Abraham Nunez | — | Milwaukee Brewers | Free agent signing |
| Jan 27, 2008 | Signed as free agent | Glendon Rusch | — | San Diego Padres | Free agent signing |
| Jan 27, 2008 | Signed as free agent | Shingo Takatsu | — | Chicago Cubs | Free agent signing |
| Jan 26, 2008 | Signed as free agent | Rod Barajas | — | Toronto Blue Jays | Free agent signing |
| Jan 26, 2008 | Signed as free agent | Nick Gorneault | — | Houston Astros | Free agent signing |
| Jan 25, 2008 | Signed as free agent | Tom Martin | — | Los Angeles Dodgers | Free agent signing |
| Jan 25, 2008 | Signed as free agent | Luis Ordaz | — | Pittsburgh Pirates | Free agent signing |
| Jan 24, 2008 | Signed as free agent | Hector Carrasco | — | Pittsburgh Pirates | Free agent signing |
| Jan 24, 2008 | Signed as free agent | Fernando Cortez | — | Chicago White Sox | Free agent signing |
| Jan 24, 2008 | Signed as free agent | Roger Deago | — | Tampa Bay Rays | Free agent signing |
| Jan 24, 2008 | Signed as free agent | Casey Fossum | — | Pittsburgh Pirates | Free agent signing |
| Jan 24, 2008 | Released | Kevin Hooper | Houston Astros | — | Release |
| Jan 24, 2008 | Signed as free agent | Lance Niekro | — | Houston Astros | Free agent signing |
| Jan 24, 2008 | Signed as free agent | Chris Woodward | — | New York Yankees | Free agent signing |
| Jan 23, 2008 | Signed as free agent | Chris Booker | — | Washington Nationals | Free agent signing |
| Jan 23, 2008 | Signed as free agent | Matt Miller | — | Boston Red Sox | Free agent signing |
| Jan 22, 2008 | Signed as free agent | Melvin Dorta | — | Pittsburgh Pirates | Free agent signing |
| Jan 22, 2008 | Signed as free agent | Octavio Dotel | — | Chicago White Sox | Free agent signing |
| Jan 22, 2008 | Signed as free agent | Jose Garcia | — | Oakland Athletics | Free agent signing |
| Jan 22, 2008 | Signed as free agent | Danny Kolb | — | Boston Red Sox | Free agent signing |
| Jan 22, 2008 | Signed as free agent | Brian Lawrence | — | Kansas City Royals | Free agent signing |
| Jan 22, 2008 | Signed as free agent | George Lombard | — | Los Angeles Dodgers | Free agent signing |
| Jan 22, 2008 | Signed as free agent | Julio Manon | — | Baltimore Orioles | Free agent signing |
| Jan 22, 2008 | Signed as free agent | Henry Mateo | — | Detroit Tigers | Free agent signing |
| Jan 22, 2008 | Signed as free agent | Mike O'Connor | — | Washington Nationals | Free agent signing |
| Jan 22, 2008 | Signed as free agent | Joe Winkelsas | — | Chicago White Sox | Free agent signing |
| Jan 22, 2008 | Signed as free agent | Jaret Wright | — | Pittsburgh Pirates | Free agent signing |
| Jan 21, 2008 | Signed as free agent | Lance Cormier | — | Baltimore Orioles | Free agent signing |
| Jan 21, 2008 | Signed as free agent | Joe Hietpas | — | New York Mets | Free agent signing |
| Jan 21, 2008 | Signed as free agent | Brett Tomko | — | Kansas City Royals | Free agent signing |
| Jan 20, 2008 | Signed as free agent | Cedrick Bowers | — | Colorado Rockies | Free agent signing |
| Jan 20, 2008 | Signed as free agent | Chan Ho Park | — | Los Angeles Dodgers | Free agent signing |
| Jan 19, 2008 | Signed as free agent | Jeremy Affeldt | — | Cincinnati Reds | Free agent signing |
| Jan 18, 2008 | Signed as free agent | Paul Phillips | — | Chicago White Sox | Free agent signing |
| Jan 18, 2008 | Signed | Alexei Ramirez | — | Chicago White Sox | Amateur free agent signing |
| Jan 18, 2008 | Signed as free agent | Arthur Rhodes | — | Seattle Mariners | Free agent signing |
| Jan 17, 2008 | Signed as free agent | Jason Jennings | — | Texas Rangers | Free agent signing |
| Jan 17, 2008 | Signed as free agent | Scott Munter | — | Tampa Bay Rays | Free agent signing |
| Jan 17, 2008 | Signed as free agent | Daniel Nava | — | Boston Red Sox | Free agent signing with first major-league team |
| Jan 17, 2008 | Signed as free agent | Danny Sandoval | — | Cleveland Indians | Free agent signing |
| Jan 17, 2008 | Trade | Willy Aybar | Atlanta Braves | Tampa Bay Rays | Trade |
| Jan 17, 2008 | Trade | Chase Fontaine | Atlanta Braves | Tampa Bay Rays | Trade |
| Jan 17, 2008 | Trade | Jeff Ridgway | Tampa Bay Rays | Atlanta Braves | Trade |
| Jan 16, 2008 | Signed as free agent | Alex Escobar | — | Washington Nationals | Free agent signing |
| Jan 16, 2008 | Signed as free agent | Mark Hendrickson | — | Florida Marlins | Free agent signing |
| Jan 16, 2008 | Signed as free agent | Ryan Jorgensen | — | Minnesota Twins | Free agent signing |
| Jan 16, 2008 | Signed as free agent | Jon Lieber | — | Chicago Cubs | Free agent signing |
| Jan 16, 2008 | Signed as free agent | Josh Phelps | — | St. Louis Cardinals | Free agent signing |
| Jan 15, 2008 | Signed as free agent | Victor Diaz | — | Houston Astros | Free agent signing |
| Jan 15, 2008 | Signed as free agent | Luis Figueroa | — | Chicago Cubs | Free agent signing |
| Jan 15, 2008 | Signed as free agent | Tim Hamulack | — | Kansas City Royals | Free agent signing |
| Jan 15, 2008 | Signed as free agent | Damon Hollins | — | Kansas City Royals | Free agent signing |
| Jan 15, 2008 | Signed as free agent | Jason Lane | — | New York Yankees | Free agent signing |
| Jan 15, 2008 | Signed as free agent | Wil Nieves | — | Washington Nationals | Free agent signing |
| Jan 15, 2008 | Signed as free agent | Kirk Saarloos | — | Oakland Athletics | Free agent signing |
| Jan 14, 2008 | Signed as free agent | Kevin Barker | — | Cincinnati Reds | Free agent signing |
| Jan 14, 2008 | Signed as free agent | Jesse Foppert | — | San Francisco Giants | Free agent signing |
| Jan 14, 2008 | Signed as free agent | Bronson Sardinha | — | Seattle Mariners | Free agent signing |
| Jan 14, 2008 | Trade | Joey Devine | Atlanta Braves | Oakland Athletics | Trade |
| Jan 14, 2008 | Trade | Jamie Richmond | Atlanta Braves | Oakland Athletics | Trade |
| Jan 14, 2008 | Trade | Mark Kotsay | Oakland Athletics | Atlanta Braves | Trade |
| Jan 14, 2008 | Trade | Troy Glaus | Toronto Blue Jays | St. Louis Cardinals | Trade |
| Jan 14, 2008 | Trade | Scott Rolen | St. Louis Cardinals | Toronto Blue Jays | Trade |
| Jan 13, 2008 | Signed as free agent | Rich Thompson | — | Boston Red Sox | Free agent signing |
| Jan 11, 2008 | Signed as free agent | Philip Barzilla | — | Seattle Mariners | Free agent signing |
| Jan 11, 2008 | Signed as free agent | Eude Brito | — | Washington Nationals | Free agent signing |
| Jan 11, 2008 | Signed as free agent | Emil Brown | — | Oakland Athletics | Free agent signing |
| Jan 11, 2008 | Signed as free agent | Mike Cameron | — | Milwaukee Brewers | Free agent signing |
| Jan 11, 2008 | Signed as free agent | D. J. Carrasco | — | Chicago White Sox | Free agent signing |
| Jan 11, 2008 | Signed as free agent | Chad Fox | — | Chicago Cubs | Free agent signing |
| Jan 11, 2008 | Signed as free agent | Eddie Guardado | — | Texas Rangers | Free agent signing |
| Jan 11, 2008 | Signed as free agent | Randy Keisler | — | Minnesota Twins | Free agent signing |
| Jan 11, 2008 | Signed as free agent | Jeff Liefer | — | Chicago White Sox | Free agent signing |
| Jan 11, 2008 | Signed as free agent | Doug Mirabelli | — | Boston Red Sox | Free agent signing |
| Jan 11, 2008 | Signed as free agent | Erasmo Ramirez | — | Milwaukee Brewers | Free agent signing |
| Jan 11, 2008 | Signed as free agent | Chin-hui Tsao | — | Kansas City Royals | Free agent signing |
| Jan 11, 2008 | Signed as free agent | Randy Williams | — | Florida Marlins | Free agent signing |
| Jan 11, 2008 | Signed | Daniel Corcino | — | Cincinnati Reds | Amateur free agent signing |
| Jan 10, 2008 | Signed as free agent | Mike DeJean | — | Houston Astros | Free agent signing |
| Jan 10, 2008 | Signed as free agent | Dave Matranga | — | Kansas City Royals | Free agent signing |
| Jan 10, 2008 | Signed as free agent | Adam Melhuse | — | Texas Rangers | Free agent signing |
| Jan 10, 2008 | Signed as free agent | Pete Orr | — | Washington Nationals | Free agent signing |
| Jan 10, 2008 | Signed as free agent | Chris Reitsma | — | Seattle Mariners | Free agent signing |
| Jan 10, 2008 | Signed as free agent | Alfredo Simon | — | Los Angeles Dodgers | Free agent signing |
| Jan 9, 2008 | Signed as free agent | Hideo Nomo | — | Kansas City Royals | Free agent signing |
| Jan 8, 2008 | Signed as free agent | Tony Blanco | — | Colorado Rockies | Free agent signing |
| Jan 8, 2008 | Signed as free agent | Mike Burns | — | Pittsburgh Pirates | Free agent signing |
| Jan 8, 2008 | Signed as free agent | Miguel Cairo | — | Seattle Mariners | Free agent signing |
| Jan 8, 2008 | Signed as free agent | Shawn Camp | — | Toronto Blue Jays | Free agent signing |
| Jan 8, 2008 | Signed as free agent | Marcus Giles | — | Colorado Rockies | Free agent signing |
| Jan 8, 2008 | Signed as free agent | Matt Ginter | — | Cleveland Indians | Free agent signing |
| Jan 8, 2008 | Signed as free agent | Ben Howard | — | Boston Red Sox | Free agent signing |
| Jan 8, 2008 | Signed as free agent | Ken Huckaby | — | Kansas City Royals | Free agent signing |
| Jan 8, 2008 | Signed as free agent | Ray King | — | Washington Nationals | Free agent signing |
| Jan 8, 2008 | Signed as free agent | Ramon Nivar | — | San Diego Padres | Free agent signing |
| Jan 8, 2008 | Signed as free agent | Matt Riley | — | Los Angeles Dodgers | Free agent signing |
| Jan 7, 2008 | Signed as free agent | Kevin Beirne | — | Philadelphia Phillies | Free agent signing |
| Jan 7, 2008 | Signed as free agent | Andy Cavazos | — | New York Mets | Free agent signing |
| Jan 7, 2008 | Signed as free agent | Zach Day | — | Minnesota Twins | Free agent signing |
| Jan 7, 2008 | Signed as free agent | Ron Flores | — | St. Louis Cardinals | Free agent signing |
| Jan 7, 2008 | Signed as free agent | J. R. House | — | Houston Astros | Free agent signing |
| Jan 6, 2008 | Signed as free agent | Mike Difelice | — | Tampa Bay Rays | Free agent signing |
| Jan 6, 2008 | Signed as free agent | Matt Kata | — | Colorado Rockies | Free agent signing |
| Jan 5, 2008 | Signed as free agent | Jason Davis | — | Texas Rangers | Free agent signing |
| Jan 5, 2008 | Trade | Angel Pagan | Chicago Cubs | New York Mets | Trade |
| Jan 5, 2008 | Trade | Corey Coles | New York Mets | Chicago Cubs | Trade |
| Jan 5, 2008 | Trade | Ryan Meyers | New York Mets | Chicago Cubs | Trade |
| Jan 4, 2008 | Signed as free agent | Brent Butler | — | Tampa Bay Rays | Free agent signing |
| Jan 4, 2008 | Signed as free agent | Darren Clarke | — | Colorado Rockies | Free agent signing |
| Jan 4, 2008 | Signed as free agent | Alexis Gomez | — | Florida Marlins | Free agent signing |
| Jan 4, 2008 | Signed as free agent | Chris Michalak | — | Cincinnati Reds | Free agent signing |
| Jan 4, 2008 | Signed as free agent | Aaron Miles | — | St. Louis Cardinals | Free agent signing |
| Jan 4, 2008 | Signed as free agent | Luis Montanez | — | Baltimore Orioles | Free agent signing |
| Jan 4, 2008 | Signed as free agent | Andy Phillips | — | Cincinnati Reds | Free agent signing |
| Jan 4, 2008 | Signed as free agent | Heath Phillips | — | New York Yankees | Free agent signing |
| Jan 4, 2008 | Signed as free agent | Jorge Piedra | — | Florida Marlins | Free agent signing |
| Jan 4, 2008 | Signed as free agent | Josh Towers | — | Colorado Rockies | Free agent signing |
| Jan 4, 2008 | Signed as free agent | Billy Traber | — | New York Yankees | Free agent signing |
| Jan 3, 2008 | Signed as free agent | Matt Clement | — | St. Louis Cardinals | Free agent signing |
| Jan 3, 2008 | Released | Roger Deago | San Diego Padres | — | Release |
| Jan 3, 2008 | Signed as free agent | Brian Esposito | — | Colorado Rockies | Free agent signing |
| Jan 3, 2008 | Signed as free agent | John Rodriguez | — | Tampa Bay Rays | Free agent signing |
| Jan 3, 2008 | Trade | Nick Swisher | Oakland Athletics | Chicago White Sox | Trade |
| Jan 3, 2008 | Trade | Ryan Sweeney | Chicago White Sox | Oakland Athletics | Trade |
| Jan 3, 2008 | Trade | Gio Gonzalez | Chicago White Sox | Oakland Athletics | Trade |
| Jan 3, 2008 | Trade | Fautino De Los Santos | Chicago White Sox | Oakland Athletics | Trade |
| Jan 2, 2008 | Signed as free agent | Victor Santos | — | San Francisco Giants | Free agent signing |
| Jan 2, 2008 | Signed | Carlos Perez | — | Toronto Blue Jays | Amateur free agent signing |
Every row is mapped onto the same trade / signing / release vocabulary the modern feed uses, with the era’s own type description kept on each row. Club names are the names of the day (the Boston Braves years, the Brooklyn Dodgers years), and each links to the franchise it is today. Some dates are only partially known or flagged approximate by the source; they are shown exactly as published, never completed to a fake precise day.