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The 2022 season’s official transaction log: 3,231 trades, signings and releases involving major-league clubs, listed newest first with MLB’s own description of each move.
| Date | Type | Player | From | To | Details |
|---|---|---|---|---|---|
| Dec 31, 2022 | Signed as free agent | Joshua Fuentes | — | Atlanta Braves | Atlanta Braves signed free agent 3B Joshua Fuentes to a minor league contract. |
| Dec 30, 2022 | Signed as free agent | Casey Lawrence | — | Toronto Blue Jays | Toronto Blue Jays signed free agent RHP Casey Lawrence to a minor league contract. |
| Dec 30, 2022 | Signed as free agent | Odalvi Javier | — | Washington Nationals | Washington Nationals signed free agent RHP Odalvi Javier to a minor league contract. |
| Dec 29, 2022 | Signed as free agent | Tucker Barnhart | — | Chicago Cubs | Chicago Cubs signed free agent C Tucker Barnhart. |
| Dec 29, 2022 | Signed as free agent | J.D. Martinez | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent DH J.D. Martinez. |
| Dec 29, 2022 | Signed as free agent | Danny Coulombe | — | Minnesota Twins | Minnesota Twins signed free agent LHP Danny Coulombe to a minor league contract. |
| Dec 29, 2022 | Signed as free agent | Tyler Danish | — | New York Yankees | New York Yankees signed free agent RHP Tyler Danish to a minor league contract. |
| Dec 29, 2022 | Signed as free agent | Erik González | — | Chicago White Sox | Chicago White Sox signed free agent 2B Erik González to a minor league contract. |
| Dec 28, 2022 | Signed as free agent | Jordan Lyles | — | Kansas City Royals | Kansas City Royals signed free agent RHP Jordan Lyles. |
| Dec 28, 2022 | Signed as free agent | Taylor Rogers | — | San Francisco Giants | San Francisco Giants signed free agent LHP Taylor Rogers. |
| Dec 28, 2022 | Signed as free agent | Jarlín García | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent LHP Jarlín García. |
| Dec 28, 2022 | Trade | Caleb Durbin | Atlanta Braves | New York Yankees | New York Yankees traded LHP Lucas Luetge to Atlanta Braves for SS Caleb Durbin and RHP Indigo Diaz. |
| Dec 28, 2022 | Signed as free agent | Jose Bravo | — | Minnesota Twins | Minnesota Twins signed free agent RHP Jose Bravo to a minor league contract. |
| Dec 28, 2022 | Signed as free agent | Ryder Jones | — | Atlanta Braves | Atlanta Braves signed free agent 1B Ryder Jones to a minor league contract. |
| Dec 28, 2022 | Signed as free agent | Domingo Tapia | — | San Diego Padres | San Diego Padres signed free agent RHP Domingo Tapia to a minor league contract. |
| Dec 27, 2022 | Signed as free agent | Adam Ottavino | — | New York Mets | New York Mets signed free agent RHP Adam Ottavino, and. |
| Dec 27, 2022 | Signed as free agent | Nathan Eovaldi | — | Texas Rangers | Texas Rangers signed free agent RHP Nathan Eovaldi. |
| Dec 27, 2022 | Signed as free agent | Brad Wieck | — | Chicago Cubs | Chicago Cubs signed free agent LHP Brad Wieck to a minor league contract. |
| Dec 27, 2022 | Signed as free agent | Brian O'Keefe | — | Seattle Mariners | Seattle Mariners signed free agent C Brian O'Keefe to a minor league contract. |
| Dec 27, 2022 | Signed as free agent | Ryan Gold | — | Texas Rangers | Texas Rangers signed free agent C Ryan Gold to a minor league contract. |
| Dec 27, 2022 | Signed as free agent | Aneurys Zabala | — | Detroit Tigers | Detroit Tigers signed free agent RHP Aneurys Zabala to a minor league contract. |
| Dec 26, 2022 | Signed as free agent | Jackson Stephens | — | Atlanta Braves | Atlanta Braves signed free agent RHP Jackson Stephens. |
| Dec 26, 2022 | Signed as free agent | Delvin Pérez | — | New York Yankees | New York Yankees signed free agent SS Delvin Pérez to a minor league contract. |
| Dec 24, 2022 | Signed as free agent | Drew Smyly | — | Chicago Cubs | Chicago Cubs signed free agent LHP Drew Smyly, and. |
| Dec 24, 2022 | Signed as free agent | Austin Romine | — | Cincinnati Reds | Cincinnati Reds signed free agent C Austin Romine to a minor league contract. |
| Dec 24, 2022 | Signed as free agent | Rafael Ortega | — | New York Yankees | New York Yankees signed free agent LF Rafael Ortega to a minor league contract. |
| Dec 24, 2022 | Signed as free agent | Jake Jewell | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RHP Jake Jewell to a minor league contract. |
| Dec 24, 2022 | Signed as free agent | Joe McCarthy | — | Texas Rangers | Texas Rangers signed free agent LF Joe McCarthy to a minor league contract. |
| Dec 23, 2022 | Trade | Diego Castillo | Pittsburgh Pirates | Arizona Diamondbacks | Pittsburgh Pirates traded SS Diego Castillo to Arizona Diamondbacks for RHP Scott Randall. |
| Dec 23, 2022 | Trade | Daulton Varsho | Arizona Diamondbacks | Toronto Blue Jays | Arizona Diamondbacks traded C Daulton Varsho to Toronto Blue Jays for SS Lourdes Gurriel Jr. and C Gabriel Moreno. |
| Dec 23, 2022 | Trade | Lewin Díaz | Baltimore Orioles | Atlanta Braves | Baltimore Orioles traded 1B Lewin Díaz to Atlanta Braves. |
| Dec 23, 2022 | Signed as free agent | Erik Stock | — | Seattle Mariners | Seattle Mariners signed free agent OF Erik Stock to a minor league contract. |
| Dec 23, 2022 | Signed as free agent | Andrew Knapp | — | Detroit Tigers | Detroit Tigers signed free agent C Andrew Knapp to a minor league contract. |
| Dec 23, 2022 | Signed as free agent | Nick Wittgren | — | Kansas City Royals | Kansas City Royals signed free agent RHP Nick Wittgren to a minor league contract. |
| Dec 23, 2022 | Signed as free agent | Willi Castro | — | Minnesota Twins | Minnesota Twins signed free agent SS Willi Castro to a minor league contract. |
| Dec 23, 2022 | Signed as free agent | Anthony Banda | — | Washington Nationals | Washington Nationals signed free agent LHP Anthony Banda to a minor league contract. |
| Dec 23, 2022 | Signed as free agent | Garrett Whitley | — | Philadelphia Phillies | Philadelphia Phillies signed free agent CF Garrett Whitley to a minor league contract. |
| Dec 22, 2022 | Signed as free agent | Wil Myers | — | Cincinnati Reds | Cincinnati Reds signed free agent 1B Wil Myers. |
| Dec 22, 2022 | Signed as free agent | Omar Narváez | — | New York Mets | New York Mets signed free agent C Omar Narváez. |
| Dec 22, 2022 | Signed as free agent | Seth Lugo | — | San Diego Padres | San Diego Padres signed free agent RHP Seth Lugo. |
| Dec 22, 2022 | Signed as free agent | Curt Casali | — | Cincinnati Reds | Cincinnati Reds signed free agent C Curt Casali. |
| Dec 22, 2022 | Trade | Gregory Santos | San Francisco Giants | Chicago White Sox | San Francisco Giants traded RHP Gregory Santos to Chicago White Sox. |
| Dec 22, 2022 | Signed as free agent | Brandon Drury | — | Los Angeles Angels | Los Angeles Angels signed free agent 3B Brandon Drury. |
| Dec 22, 2022 | Released | Eric Hosmer | — | Boston Red Sox | Boston Red Sox released 1B Eric Hosmer. |
| Dec 22, 2022 | Signed as free agent | Danny Mendick | — | New York Mets | New York Mets signed free agent SS Danny Mendick. |
| Dec 22, 2022 | Signed as free agent | Jose Mena | — | New York Mets | New York Mets signed free agent C Jose Mena to a minor league contract. |
| Dec 22, 2022 | Signed as free agent | Brett Cumberland | — | San Francisco Giants | San Francisco Giants signed free agent C Brett Cumberland to a minor league contract. |
| Dec 22, 2022 | Signed as free agent | Mike Mayers | — | Kansas City Royals | Kansas City Royals signed free agent RHP Mike Mayers to a minor league contract. |
| Dec 22, 2022 | Signed as free agent | Wilmer Difo | — | New York Yankees | New York Yankees signed free agent 2B Wilmer Difo to a minor league contract. |
| Dec 22, 2022 | Signed as free agent | Jacob Nottingham | — | Seattle Mariners | Seattle Mariners signed free agent C Jacob Nottingham to a minor league contract. |
| Dec 22, 2022 | Signed as free agent | Oliver Garcia | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent RHP Oliver Garcia to a minor league contract. |
| Dec 21, 2022 | Signed as free agent | Mychal Givens | — | Baltimore Orioles | Baltimore Orioles signed free agent RHP Mychal Givens. |
| Dec 21, 2022 | Signed as free agent | Michael Brantley | — | Houston Astros | Houston Astros signed free agent DH Michael Brantley. |
| Dec 21, 2022 | Signed as free agent | Unnamed | — | Chicago Cubs | Chicago Cubs signed free agent SS Dansby Swanson, and. |
| Dec 21, 2022 | Signed as free agent | Carlos Rodón | — | New York Yankees | New York Yankees signed free agent LHP Carlos Rodón. |
| Dec 21, 2022 | Signed as free agent | Caleb Simpson | — | Cleveland Guardians | Cleveland Guardians signed free agent RHP Caleb Simpson to a minor league contract and invited him to spring training. |
| Dec 21, 2022 | Signed as free agent | Drew Rucinski | — | Athletics | Oakland Athletics signed free agent RHP Drew Rucinski. |
| Dec 21, 2022 | Signed as free agent | Niko Goodrum | — | Boston Red Sox | Boston Red Sox signed free agent 1B Niko Goodrum to a minor league contract and invited him to spring training. |
| Dec 21, 2022 | Signed as free agent | Tommy Kahnle | — | New York Yankees | New York Yankees signed free agent RHP Tommy Kahnle. |
| Dec 21, 2022 | Trade | James McCann | New York Mets | Baltimore Orioles | New York Mets traded C James McCann to Baltimore Orioles. |
| Dec 21, 2022 | Released | Yoan López | — | New York Mets | New York Mets released RHP Yoan López. |
| Dec 21, 2022 | Signed as free agent | Jim Haley | — | Philadelphia Phillies | Philadelphia Phillies signed free agent 3B Jim Haley to a minor league contract. |
| Dec 21, 2022 | Signed as free agent | Pedro Severino | — | San Diego Padres | San Diego Padres signed free agent C Pedro Severino to a minor league contract. |
| Dec 21, 2022 | Signed as free agent | Casey Sadler | — | Seattle Mariners | Seattle Mariners signed free agent RHP Casey Sadler to a minor league contract. |
| Dec 21, 2022 | Signed as free agent | Gerson Moreno | — | Washington Nationals | Washington Nationals signed free agent RHP Gerson Moreno to a minor league contract. |
| Dec 21, 2022 | Signed as free agent | Braden Bristo | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP Braden Bristo to a minor league contract. |
| Dec 20, 2022 | Signed as free agent | Joey Gallo | — | Minnesota Twins | Minnesota Twins signed free agent LF Joey Gallo. |
| Dec 20, 2022 | Signed as free agent | Erasmo Ramírez | — | Washington Nationals | Washington Nationals signed free agent RHP Erasmo Ramirez. |
| Dec 20, 2022 | Signed as free agent | Michael Lorenzen | — | Detroit Tigers | Detroit Tigers signed free agent RHP Michael Lorenzen. |
| Dec 20, 2022 | Signed as free agent | Matt Carpenter | — | San Diego Padres | San Diego Padres signed free agent DH Matt Carpenter. |
| Dec 20, 2022 | Signed as free agent | Austin Hedges | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent C Austin Hedges. |
| Dec 20, 2022 | Signed as free agent | Eddy Alvarez | — | Milwaukee Brewers | Milwaukee Brewers signed free agent SS Eddy Alvarez to a minor league contract and invited him to spring training. |
| Dec 20, 2022 | Signed as free agent | Collin Wiles | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Collin Wiles to a minor league contract and invited him to spring training. |
| Dec 20, 2022 | Signed as free agent | Thomas Pannone | — | Milwaukee Brewers | Milwaukee Brewers signed free agent LHP Thomas Pannone to a minor league contract and invited him to spring training. |
| Dec 20, 2022 | Signed as free agent | Jake Fishman | — | Athletics | Oakland Athletics signed free agent LHP Jake Fishman to a minor league contract and invited him to spring training. |
| Dec 20, 2022 | Signed as free agent | Tyler Wade | — | Athletics | Oakland Athletics signed free agent 2B Tyler Wade to a minor league contract and invited him to spring training. |
| Dec 20, 2022 | Signed as free agent | Roenis Elías | — | Chicago Cubs | Chicago Cubs signed free agent LHP Roenis Elías to a minor league contract. |
| Dec 20, 2022 | Signed as free agent | Nolan Machibroda | — | Minnesota Twins | Minnesota Twins signed free agent 1B Nolan Machibroda to a minor league contract. |
| Dec 20, 2022 | Signed as free agent | Alejandro Mateo | — | Chicago White Sox | Chicago White Sox signed free agent RHP Alejandro Mateo to a minor league contract. |
| Dec 20, 2022 | Signed as free agent | Jesse Scholtens | — | Chicago White Sox | Chicago White Sox signed free agent RHP Jesse Scholtens to a minor league contract. |
| Dec 20, 2022 | Signed as free agent | Oscar Campos | — | New York Mets | New York Mets signed free agent C Oscar Campos to a minor league contract. |
| Dec 20, 2022 | Signed as free agent | Lorenzo Cedrola | — | New York Mets | New York Mets signed free agent CF Lorenzo Cedrola to a minor league contract. |
| Dec 20, 2022 | Signed as free agent | Clint Coulter | — | San Francisco Giants | San Francisco Giants signed free agent RF Clint Coulter to a minor league contract. |
| Dec 20, 2022 | Signed as free agent | Garrett Hampson | — | Miami Marlins | Miami Marlins signed free agent SS Garrett Hampson to a minor league contract. |
| Dec 20, 2022 | Signed as free agent | T.J. McFarland | — | New York Mets | New York Mets signed free agent LHP T.J. McFarland to a minor league contract. |
| Dec 20, 2022 | Signed as free agent | Drew Maggi | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent SS Drew Maggi to a minor league contract. |
| Dec 20, 2022 | Signed as free agent | Aaron Judge | — | New York Yankees | New York Yankees signed free agent RF Aaron Judge. |
| Dec 19, 2022 | Signed as free agent | Jameson Taillon | — | Chicago Cubs | Chicago Cubs signed free agent RHP Jameson Taillon. |
| Dec 19, 2022 | Signed as free agent | Eduard Bazardo | — | Baltimore Orioles | Baltimore Orioles signed free agent RHP Eduard Bazardo to a minor league contract. |
| Dec 19, 2022 | Signed as free agent | Wandisson Charles | — | Baltimore Orioles | Baltimore Orioles signed free agent RHP Wandisson Charles to a minor league contract. |
| Dec 19, 2022 | Signed as free agent | Kyle Dowdy | — | Baltimore Orioles | Baltimore Orioles signed free agent RHP Kyle Dowdy to a minor league contract. |
| Dec 19, 2022 | Signed as free agent | Sean Manaea | — | San Francisco Giants | San Francisco Giants signed free agent LHP Sean Manaea, and. |
| Dec 19, 2022 | Signed as free agent | Jordan Luplow | — | Atlanta Braves | Atlanta Braves signed free agent LF Jordan Luplow. |
| Dec 19, 2022 | Signed as free agent | Sergio Alcántara | — | Chicago Cubs | Chicago Cubs signed free agent SS Sergio Alcántara to a minor league contract. |
| Dec 19, 2022 | Signed as free agent | BJ Boyd | — | Los Angeles Angels | Los Angeles Angels signed free agent LF BJ Boyd to a minor league contract. |
| Dec 19, 2022 | Signed as free agent | Tim Lopes | — | San Diego Padres | San Diego Padres signed free agent 2B Tim Lopes to a minor league contract. |
| Dec 19, 2022 | Signed as free agent | Ryder Ryan | — | Seattle Mariners | Seattle Mariners signed free agent RHP Ryder Ryan to a minor league contract. |
| Dec 19, 2022 | Signed as free agent | Jose Ulloa | — | Washington Nationals | Washington Nationals signed free agent RHP Jose Ulloa to a minor league contract. |
| Dec 19, 2022 | Signed as free agent | Matt Adams | — | Washington Nationals | Washington Nationals signed free agent 1B Matt Adams to a minor league contract. |
| Dec 19, 2022 | Signed as free agent | Travis Blankenhorn | — | Washington Nationals | Washington Nationals signed free agent 3B Travis Blankenhorn to a minor league contract. |
| Dec 19, 2022 | Signed as free agent | Anthony Castro | — | Washington Nationals | Washington Nationals signed free agent RHP Anthony Castro to a minor league contract. |
| Dec 19, 2022 | Signed as free agent | Tommy Romero | — | Washington Nationals | Washington Nationals signed free agent RHP Tommy Romero to a minor league contract. |
| Dec 19, 2022 | Signed as free agent | Paxton Wallace | — | Kansas City Royals | Kansas City Royals signed free agent 3B Paxton Wallace to a minor league contract. |
| Dec 19, 2022 | Signed as free agent | Jake Lamb | — | Los Angeles Angels | Los Angeles Angels signed free agent 3B Jake Lamb to a minor league contract. |
| Dec 19, 2022 | Signed as free agent | Gerardo Reyes | — | Los Angeles Angels | Los Angeles Angels signed free agent RHP Gerardo Reyes to a minor league contract. |
| Dec 19, 2022 | Signed as free agent | Cam Vieaux | — | Los Angeles Angels | Los Angeles Angels signed free agent LHP Cam Vieaux to a minor league contract. |
| Dec 19, 2022 | Signed as free agent | Billy McKinney | — | New York Yankees | New York Yankees signed free agent LF Billy McKinney to a minor league contract. |
| Dec 19, 2022 | Signed as free agent | Wendell Rijo | — | Philadelphia Phillies | Philadelphia Phillies signed free agent 2B Wendell Rijo to a minor league contract. |
| Dec 19, 2022 | Signed as free agent | Nick Ward | — | Philadelphia Phillies | Philadelphia Phillies signed free agent 2B Nick Ward to a minor league contract. |
| Dec 19, 2022 | Signed as free agent | Kelvin Melean | — | San Diego Padres | San Diego Padres signed free agent SS Kelvin Melean to a minor league contract. |
| Dec 19, 2022 | Signed as free agent | Max Schrock | — | San Diego Padres | San Diego Padres signed free agent 2B Max Schrock to a minor league contract. |
| Dec 19, 2022 | Signed as free agent | Caleb Baragar | — | Cleveland Guardians | Cleveland Guardians signed free agent LHP Caleb Baragar to a minor league contract. |
| Dec 19, 2022 | Signed as free agent | Billy Hamilton | — | Chicago White Sox | Chicago White Sox signed free agent CF Billy Hamilton to a minor league contract. |
| Dec 19, 2022 | Signed as free agent | Brantley Bell | — | San Diego Padres | San Diego Padres signed free agent 3B Brantley Bell to a minor league contract. |
| Dec 19, 2022 | Signed as free agent | Tyler Chatwood | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent RHP Tyler Chatwood to a minor league contract. |
| Dec 18, 2022 | Trade | Connor Joe | Colorado Rockies | Pittsburgh Pirates | Colorado Rockies traded 3B Connor Joe to Pittsburgh Pirates for RHP Nick Garcia. |
| Dec 18, 2022 | Signed as free agent | José Mujica | — | Washington Nationals | Washington Nationals signed free agent RHP José Mujica to a minor league contract. |
| Dec 17, 2022 | Signed as free agent | Kodai Senga | — | New York Mets | New York Mets signed free agent RHP Kodai Senga. |
| Dec 17, 2022 | Signed as free agent | Cole Tucker | — | Colorado Rockies | Colorado Rockies signed free agent SS Cole Tucker to a minor league contract. |
| Dec 17, 2022 | Signed as free agent | Nick Podkul | — | Philadelphia Phillies | Philadelphia Phillies signed free agent 3B Nick Podkul to a minor league contract. |
| Dec 17, 2022 | Signed as free agent | Steven Duggar | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent CF Steven Duggar to a minor league contract. |
| Dec 17, 2022 | Signed as free agent | Bradley Zimmer | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent CF Bradley Zimmer to a minor league contract. |
| Dec 16, 2022 | Signed as free agent | Taijuan Walker | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RHP Taijuan Walker, and. |
| Dec 16, 2022 | Signed as free agent | Christian Vázquez | — | Minnesota Twins | Minnesota Twins signed free agent C Christian Vázquez. |
| Dec 16, 2022 | Signed as free agent | Trevor May | — | Athletics | Oakland Athletics signed free agent RHP Trevor May. |
| Dec 16, 2022 | Trade | Unnamed | Atlanta Braves | Boston Red Sox | Boston Red Sox traded SS Hoy Park to Atlanta Braves for Player To Be Named Later. |
| Dec 16, 2022 | Signed as free agent | Noah Syndergaard | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Noah Syndergaard. |
| Dec 16, 2022 | Signed as free agent | Abraham Almonte | — | New York Mets | New York Mets signed free agent CF Abraham Almonte and to a minor league contract and invited him to spring training. |
| Dec 16, 2022 | Signed as free agent | Chris Bassitt | — | Toronto Blue Jays | Toronto Blue Jays signed free agent RHP Chris Bassitt. |
| Dec 16, 2022 | Trade | Jacob Wallace | Boston Red Sox | Kansas City Royals | Kansas City Royals traded RHP Wyatt Mills to Boston Red Sox for RHP Jacob Wallace. |
| Dec 16, 2022 | Signed as free agent | Matt Mullenbach | — | Minnesota Twins | Minnesota Twins signed free agent RHP Matt Mullenbach to a minor league contract. |
| Dec 16, 2022 | Signed as free agent | Brian Gonzalez | — | San Diego Padres | San Diego Padres signed free agent LHP Brian Gonzalez to a minor league contract. |
| Dec 16, 2022 | Signed as free agent | José Godoy | — | Los Angeles Angels | Los Angeles Angels signed free agent C José Godoy to a minor league contract. |
| Dec 16, 2022 | Signed as free agent | Jake Kalish | — | Los Angeles Angels | Los Angeles Angels signed free agent LHP Jake Kalish to a minor league contract. |
| Dec 16, 2022 | Signed as free agent | Joe Rizzo | — | Miami Marlins | Miami Marlins signed free agent 3B Joe Rizzo to a minor league contract. |
| Dec 16, 2022 | Signed as free agent | Cody Poteet | — | Kansas City Royals | Kansas City Royals signed free agent RHP Cody Poteet to a minor league contract. |
| Dec 15, 2022 | Signed as free agent | Mike Zunino | — | Cleveland Guardians | Cleveland Guardians signed free agent C Mike Zunino. |
| Dec 15, 2022 | Signed as free agent | Masataka Yoshida | — | Boston Red Sox | Boston Red Sox signed free agent Masataka Yoshida, , and. |
| Dec 15, 2022 | Signed as free agent | Adam Frazier | — | Baltimore Orioles | Baltimore Orioles signed free agent 2B Adam Frazier. |
| Dec 15, 2022 | Signed as free agent | Scott McGough | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Scott McGough. |
| Dec 15, 2022 | Signed as free agent | Angel Anazco | — | Texas Rangers | Texas Rangers signed free agent LHP Angel Anazco to a minor league contract. |
| Dec 15, 2022 | Signed as free agent | Jhon Diaz | — | Houston Astros | Houston Astros signed free agent SS Jhon Diaz to a minor league contract. |
| Dec 15, 2022 | Signed as free agent | Danell Figueroa | — | Texas Rangers | Texas Rangers signed free agent C Danell Figueroa to a minor league contract. |
| Dec 15, 2022 | Signed as free agent | Jank Pichardo | — | Houston Astros | Houston Astros signed free agent RHP Jank Pichardo to a minor league contract. |
| Dec 15, 2022 | Signed as free agent | Aniel Mendoza | — | Texas Rangers | Texas Rangers signed free agent SS Aniel Mendoza to a minor league contract. |
| Dec 15, 2022 | Signed as free agent | Cristopfer Gonzalez | — | Houston Astros | Houston Astros signed free agent Cristopfer Gonzalez to a minor league contract. |
| Dec 15, 2022 | Trade | Yonny Hernández | Athletics | Los Angeles Dodgers | Oakland Athletics traded 2B Yonny Hernandez to Los Angeles Dodgers for cash. |
| Dec 15, 2022 | Signed as free agent | Brad Boxberger | — | Chicago Cubs | Chicago Cubs signed free agent RHP Brad Boxberger. |
| Dec 15, 2022 | Signed as free agent | Darwin Rodriguez | — | Kansas City Royals | Kansas City Royals signed free agent LHP Darwin Rodriguez to a minor league contract. |
| Dec 15, 2022 | Signed as free agent | Eddy Peralta | — | Texas Rangers | Texas Rangers signed free agent RHP Eddy Peralta to a minor league contract. |
| Dec 15, 2022 | Signed as free agent | Matt Carasiti | — | Colorado Rockies | Colorado Rockies signed free agent RHP Matt Carasiti to a minor league contract. |
| Dec 15, 2022 | Signed as free agent | Anderson Espinoza | — | San Diego Padres | San Diego Padres signed free agent RHP Anderson Espinoza to a minor league contract. |
| Dec 15, 2022 | Signed as free agent | Eric Hanhold | — | San Diego Padres | San Diego Padres signed free agent RHP Eric Hanhold to a minor league contract. |
| Dec 15, 2022 | Signed as free agent | Luis Barrera | — | Los Angeles Angels | Los Angeles Angels signed free agent LF Luis Barrera to a minor league contract. |
| Dec 15, 2022 | Signed as free agent | Jose Gomez | — | Los Angeles Angels | Los Angeles Angels signed free agent 3B Jose Gomez to a minor league contract. |
| Dec 15, 2022 | Signed as free agent | Kevin Padlo | — | Los Angeles Angels | Los Angeles Angels signed free agent 3B Kevin Padlo to a minor league contract. |
| Dec 15, 2022 | Signed as free agent | Mitchell Tolman | — | Atlanta Braves | Atlanta Braves signed free agent 2B Mitchell Tolman to a minor league contract. |
| Dec 14, 2022 | Signed as free agent | Matthew Boyd | — | Detroit Tigers | Detroit Tigers signed free agent LHP Matthew Boyd. |
| Dec 14, 2022 | Signed as free agent | Unnamed | — | Chicago Cubs | Chicago Cubs signed free agent 1B Cody Bellinger, and. |
| Dec 14, 2022 | Trade | Jeff Belge | Los Angeles Dodgers | Tampa Bay Rays | Tampa Bay Rays traded RHP J.P. Feyereisen to Los Angeles Dodgers for LHP Jeff Belge. |
| Dec 14, 2022 | Trade | Owen Miller | Cleveland Guardians | Milwaukee Brewers | Cleveland Guardians traded SS Owen Miller to Milwaukee Brewers for Player To Be Named Later. |
| Dec 14, 2022 | Signed as free agent | Kevin Kiermaier | — | Toronto Blue Jays | Toronto Blue Jays signed free agent CF Kevin Kiermaier. |
| Dec 14, 2022 | Signed as free agent | Mervin Fell | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Mervin Fell to a minor league contract. |
| Dec 14, 2022 | Signed as free agent | Luis Garcia | — | Texas Rangers | Texas Rangers signed free agent LHP Luis Garcia to a minor league contract. |
| Dec 14, 2022 | Signed as free agent | Brayan Polanco | — | Athletics | Oakland Athletics signed free agent RHP Brayan Polanco to a minor league contract. |
| Dec 14, 2022 | Signed as free agent | Brooks Kriske | — | Kansas City Royals | Kansas City Royals signed free agent RHP Brooks Kriske to a minor league contract. |
| Dec 14, 2022 | Signed as free agent | Michael Hermosillo | — | New York Yankees | New York Yankees signed free agent RF Michael Hermosillo to a minor league contract. |
| Dec 14, 2022 | Signed as free agent | Garrett Williams | — | Athletics | Oakland Athletics signed free agent LHP Garrett Williams to a minor league contract. |
| Dec 14, 2022 | Signed as free agent | Juan Guilarte | — | San Francisco Giants | San Francisco Giants signed free agent RHP Juan Guilarte to a minor league contract. |
| Dec 14, 2022 | Signed as free agent | Haniel De Frias | — | San Francisco Giants | San Francisco Giants signed free agent RHP Haniel De Frias to a minor league contract. |
| Dec 14, 2022 | Signed as free agent | Scott Engler | — | Texas Rangers | Texas Rangers signed free agent RHP Scott Engler to a minor league contract. |
| Dec 13, 2022 | Signed as free agent | Vince Velasquez | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent RHP Vince Velasquez. |
| Dec 13, 2022 | Signed as free agent | Zach Eflin | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP Zach Eflin. |
| Dec 13, 2022 | Signed as free agent | Pierce Johnson | — | Colorado Rockies | Colorado Rockies signed free agent RHP Pierce Johnson. |
| Dec 13, 2022 | Signed as free agent | Kenley Jansen | — | Boston Red Sox | Boston Red Sox signed free agent RHP Kenley Jansen. |
| Dec 13, 2022 | Signed as free agent | Ross Stripling | — | San Francisco Giants | San Francisco Giants signed free agent RHP Ross Stripling. |
| Dec 13, 2022 | Signed as free agent | Aledmys Díaz | — | Athletics | Oakland Athletics signed free agent SS Aledmys Díaz. |
| Dec 13, 2022 | Signed as free agent | Jace Peterson | — | Athletics | Oakland Athletics signed free agent 2B Jace Peterson. |
| Dec 13, 2022 | Signed as free agent | Justin Garza | — | Los Angeles Angels | Los Angeles Angels signed free agent RHP Justin Garza. |
| Dec 13, 2022 | Trade | Jake Wong | San Francisco Giants | Cincinnati Reds | San Francisco Giants traded RHP Jake Wong to Cincinnati Reds. |
| Dec 13, 2022 | Signed as free agent | Ryan Yarbrough | — | Kansas City Royals | Kansas City Royals signed free agent LHP Ryan Yarbrough. |
| Dec 13, 2022 | Signed as free agent | Yansel Marine | — | Atlanta Braves | Atlanta Braves signed free agent LHP Yansel Marine to a minor league contract. |
| Dec 13, 2022 | Signed as free agent | Mariano Salomon | — | New York Yankees | New York Yankees signed free agent RHP Mariano Salomon to a minor league contract. |
| Dec 13, 2022 | Signed as free agent | Joel Garcia | — | Minnesota Twins | Minnesota Twins signed free agent RHP Joel Garcia to a minor league contract. |
| Dec 13, 2022 | Signed as free agent | Niurby Asigen | — | New York Yankees | New York Yankees signed free agent Niurby Asigen to a minor league contract. |
| Dec 13, 2022 | Signed as free agent | Adrian Gonzalez | — | New York Yankees | New York Yankees signed free agent 3B Adrian Gonzalez to a minor league contract. |
| Dec 13, 2022 | Signed as free agent | Dari Brito | — | New York Yankees | New York Yankees signed free agent RHP Dari Brito to a minor league contract. |
| Dec 13, 2022 | Signed as free agent | Boris Vecerka | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Boris Vecerka to a minor league contract. |
| Dec 13, 2022 | Signed as free agent | Luis Jerez | — | Boston Red Sox | Boston Red Sox signed free agent RHP Luis Jerez to a minor league contract. |
| Dec 13, 2022 | Signed as free agent | Michell Chirinos | — | New York Yankees | New York Yankees signed free agent RHP Michell Chirinos to a minor league contract. |
| Dec 13, 2022 | Signed as free agent | Ronny Lopez | — | Chicago Cubs | Chicago Cubs signed free agent RHP Ronny Lopez to a minor league contract. |
| Dec 13, 2022 | Signed as free agent | Jose Vasquez | — | Minnesota Twins | Minnesota Twins signed free agent RHP Jose Vasquez to a minor league contract. |
| Dec 13, 2022 | Signed as free agent | Ovandy Frias | — | New York Yankees | New York Yankees signed free agent SS Ovandy Frias to a minor league contract. |
| Dec 13, 2022 | Signed as free agent | Eric Stout | — | Chicago Cubs | Chicago Cubs signed free agent LHP Eric Stout to a minor league contract. |
| Dec 13, 2022 | Signed as free agent | T.J. Zeuch | — | Colorado Rockies | Colorado Rockies signed free agent RHP T.J. Zeuch to a minor league contract. |
| Dec 13, 2022 | Signed as free agent | Seuly Matias | — | Kansas City Royals | Kansas City Royals signed free agent CF Seuly Matias to a minor league contract. |
| Dec 13, 2022 | Signed as free agent | Adam Kolarek | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent LHP Adam Kolarek to a minor league contract. |
| Dec 13, 2022 | Signed as free agent | Jhonathan Díaz | — | Los Angeles Angels | Los Angeles Angels signed free agent LHP Jhonathan Diaz to a minor league contract. |
| Dec 13, 2022 | Signed as free agent | Brady Whalen | — | San Francisco Giants | San Francisco Giants signed free agent 2B Brady Whalen to a minor league contract. |
| Dec 13, 2022 | Signed as free agent | Sebastián Rivero | — | Chicago White Sox | Chicago White Sox signed free agent C Sebastian Rivero to a minor league contract. |
| Dec 13, 2022 | Signed as free agent | Patrick Mazeika | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent C Patrick Mazeika to a minor league contract. |
| Dec 13, 2022 | Signed as free agent | Nick Shumpert | — | Washington Nationals | Washington Nationals signed free agent SS Nick Shumpert to a minor league contract. |
| Dec 13, 2022 | Signed as free agent | Bryan Hudson | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent LHP Bryan Hudson to a minor league contract. |
| Dec 13, 2022 | Signed as free agent | Fernando Romero | — | Los Angeles Angels | Los Angeles Angels signed free agent RHP Fernando Romero to a minor league contract. |
| Dec 12, 2022 | Signed as free agent | Josh Bell | — | Cleveland Guardians | Cleveland Guardians signed free agent 1B Josh Bell. |
| Dec 12, 2022 | Trade | Freddy Tarnok | Atlanta Braves | Athletics | Atlanta Braves traded RHP Freddy Tarnok, C Manny Piña, RHP Royber Salinas, 2B Esteury Ruiz and LHP Kyle Muller to Oakland Athletics for C Sean Murphy. |
| Dec 12, 2022 | Signed as free agent | Victor Reyes | — | Chicago White Sox | Chicago White Sox signed free agent CF Victor Reyes to a minor league contract. |
| Dec 12, 2022 | Signed as free agent | Jake Pilarski | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Jake Pilarski to a minor league contract. |
| Dec 12, 2022 | Signed as free agent | Sam Clay | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent LHP Sam Clay to a minor league contract. |
| Dec 12, 2022 | Signed as free agent | Reilin Ramirez | — | Washington Nationals | Washington Nationals signed free agent RHP Reilin Ramirez to a minor league contract. |
| Dec 12, 2022 | Signed as free agent | Rafael Tabolda | — | Texas Rangers | Texas Rangers signed free agent RHP Rafael Tabolda to a minor league contract. |
| Dec 12, 2022 | Signed as free agent | Ben DeLuzio | — | Chicago Cubs | Chicago Cubs signed free agent CF Ben DeLuzio to a minor league contract. |
| Dec 12, 2022 | Signed as free agent | Jakson Reetz | — | Kansas City Royals | Kansas City Royals signed free agent C Jakson Reetz to a minor league contract. |
| Dec 12, 2022 | Signed as free agent | Chi Chi González | — | Miami Marlins | Miami Marlins signed free agent RHP Chi Chi González to a minor league contract. |
| Dec 12, 2022 | Signed as free agent | Samuel Perez | — | Minnesota Twins | Minnesota Twins signed free agent LHP Samuel Perez to a minor league contract. |
| Dec 12, 2022 | Signed as free agent | Tanner Tully | — | New York Yankees | New York Yankees signed free agent LHP Tanner Tully to a minor league contract. |
| Dec 12, 2022 | Signed as free agent | Ryan Weber | — | New York Yankees | New York Yankees signed free agent RHP Ryan Weber to a minor league contract. |
| Dec 12, 2022 | Signed as free agent | Deolis Guerra | — | Athletics | Oakland Athletics signed free agent RHP Deolis Guerra to a minor league contract. |
| Dec 12, 2022 | Signed as free agent | Aaron Brooks | — | San Diego Padres | San Diego Padres signed free agent RHP Aaron Brooks to a minor league contract. |
| Dec 12, 2022 | Signed as free agent | Raymond Burgos | — | San Francisco Giants | San Francisco Giants signed free agent LHP Raymond Burgos to a minor league contract. |
| Dec 12, 2022 | Signed as free agent | Kervin Castro | — | Detroit Tigers | Detroit Tigers signed free agent RHP Kervin Castro to a minor league contract. |
| Dec 12, 2022 | Signed as free agent | Ehire Adrianza | — | Atlanta Braves | Atlanta Braves signed free agent SS Ehire Adrianza to a minor league contract. |
| Dec 11, 2022 | Signed as free agent | Josue Juarez | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP Josue Juarez to a minor league contract. |
| Dec 11, 2022 | Signed as free agent | Ricardo Genovés | — | San Francisco Giants | San Francisco Giants signed free agent C Ricardo Genovés to a minor league contract. |
| Dec 11, 2022 | Signed as free agent | Colten Brewer | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP Colten Brewer to a minor league contract. |
| Dec 11, 2022 | Signed as free agent | Brendan McKay | — | Tampa Bay Rays | Tampa Bay Rays signed free agent LHP Brendan McKay to a minor league contract. |
| Dec 11, 2022 | Signed as free agent | Rodney Hutchison | — | Seattle Mariners | Seattle Mariners signed free agent RHP Rodney Hutchison to a minor league contract. |
| Dec 10, 2022 | Signed as free agent | Brandon Nimmo | — | New York Mets | New York Mets signed free agent RF Brandon Nimmo, and. |
| Dec 10, 2022 | Signed as free agent | Trevor Williams | — | Washington Nationals | Washington Nationals signed free agent RHP Trevor Williams. |
| Dec 10, 2022 | Signed as free agent | Harlem Belen | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent SS Harlem Belen to a minor league contract. |
| Dec 10, 2022 | Signed as free agent | Jorge Minyety | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Jorge Minyety to a minor league contract. |
| Dec 10, 2022 | Signed as free agent | Phillips Valdez | — | Colorado Rockies | Colorado Rockies signed free agent RHP Phillips Valdez to a minor league contract. |
| Dec 10, 2022 | Signed as free agent | James Jones | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent CF James Jones to a minor league contract. |
| Dec 10, 2022 | Signed as free agent | C.J. Hinojosa | — | Miami Marlins | Miami Marlins signed free agent SS C.J. Hinojosa to a minor league contract. |
| Dec 10, 2022 | Signed as free agent | Patrick Murphy | — | Minnesota Twins | Minnesota Twins signed free agent RHP Patrick Murphy to a minor league contract. |
| Dec 10, 2022 | Signed as free agent | José Peraza | — | New York Mets | New York Mets signed free agent SS José Peraza to a minor league contract. |
| Dec 10, 2022 | Signed as free agent | Max McDowell | — | Philadelphia Phillies | Philadelphia Phillies signed free agent C Max McDowell to a minor league contract. |
| Dec 10, 2022 | Signed as free agent | Raul Brito | — | San Diego Padres | San Diego Padres signed free agent RHP Raul Brito to a minor league contract. |
| Dec 10, 2022 | Signed as free agent | Drew Carlton | — | San Diego Padres | San Diego Padres signed free agent RHP Drew Carlton to a minor league contract. |
| Dec 10, 2022 | Signed as free agent | Tommy Milone | — | Seattle Mariners | Seattle Mariners signed free agent LHP Tommy Milone to a minor league contract. |
| Dec 10, 2022 | Signed as free agent | Armando Alvarez | — | San Francisco Giants | San Francisco Giants signed free agent 3B Armando Alvarez to a minor league contract. |
| Dec 10, 2022 | Signed as free agent | Nick Duron | — | San Francisco Giants | San Francisco Giants signed free agent RHP Nick Duron to a minor league contract. |
| Dec 10, 2022 | Signed as free agent | Ljay Newsome | — | San Francisco Giants | San Francisco Giants signed free agent RHP Ljay Newsome to a minor league contract. |
| Dec 10, 2022 | Signed as free agent | Enmanuel De Jesus | — | Miami Marlins | Miami Marlins signed free agent LHP Enmanuel De Jesus to a minor league contract. |
| Dec 10, 2022 | Signed as free agent | Tyler Heineman | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent C Tyler Heineman to a minor league contract. |
| Dec 9, 2022 | Signed as free agent | Matt Strahm | — | Philadelphia Phillies | Philadelphia Phillies signed free agent LHP Matt Strahm. |
| Dec 9, 2022 | Signed as free agent | Willson Contreras | — | St. Louis Cardinals | St. Louis Cardinals signed free agent C Willson Contreras, and. |
| Dec 9, 2022 | Signed as free agent | Xander Bogaerts | — | San Diego Padres | San Diego Padres signed free agent SS Xander Bogaerts. |
| Dec 9, 2022 | Signed as free agent | Andrew Heaney | — | Texas Rangers | Texas Rangers signed free agent LHP Andrew Heaney. |
| Dec 9, 2022 | Signed as free agent | Nick Snyder | — | Texas Rangers | Texas Rangers signed free agent RHP Nick Snyder to a minor league contract. |
| Dec 9, 2022 | Signed as free agent | Jose Quintana | — | New York Mets | New York Mets signed free agent LHP José Quintana. |
| Dec 9, 2022 | Signed as free agent | David Robertson | — | New York Mets | New York Mets signed free agent RHP David Robertson. |
| Dec 9, 2022 | Signed as free agent | Ryan Hendrix | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Ryan Hendrix to a minor league contract. |
| Dec 9, 2022 | Signed as free agent | José De León | — | Minnesota Twins | Minnesota Twins signed free agent RHP José De León to a minor league contract. |
| Dec 9, 2022 | Signed as free agent | Jake Bauers | — | New York Yankees | New York Yankees signed free agent DH Jake Bauers to a minor league contract. |
| Dec 9, 2022 | Signed as free agent | Tyler Ferguson | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Tyler Ferguson to a minor league contract. |
| Dec 9, 2022 | Signed as free agent | Zach McAllister | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Zach McAllister to a minor league contract. |
| Dec 9, 2022 | Signed as free agent | Xavier Fernández | — | Chicago White Sox | Chicago White Sox signed free agent C Xavier Fernández to a minor league contract. |
| Dec 9, 2022 | Signed as free agent | Luis Amaya | — | Milwaukee Brewers | Milwaukee Brewers signed free agent LHP Luis Amaya to a minor league contract. |
| Dec 9, 2022 | Signed as free agent | Christian Mejias | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Christian Mejias to a minor league contract. |
| Dec 9, 2022 | Signed as free agent | James Norwood | — | New York Yankees | New York Yankees signed free agent RHP James Norwood to a minor league contract. |
| Dec 9, 2022 | Signed as free agent | Nick Ramirez | — | New York Yankees | New York Yankees signed free agent LHP Nick Ramirez to a minor league contract. |
| Dec 9, 2022 | Signed as free agent | Yohel Pozo | — | Athletics | Oakland Athletics signed free agent C Yohel Pozo to a minor league contract. |
| Dec 9, 2022 | Signed as free agent | Preston Tucker | — | San Diego Padres | San Diego Padres signed free agent LF Preston Tucker to a minor league contract. |
| Dec 9, 2022 | Signed as free agent | Nick Dini | — | Tampa Bay Rays | Tampa Bay Rays signed free agent C Nick Dini to a minor league contract. |
| Dec 9, 2022 | Signed as free agent | Connor Kaiser | — | Colorado Rockies | Colorado Rockies signed free agent SS Connor Kaiser to a minor league contract. |
| Dec 9, 2022 | Signed as free agent | Frederik Jimenez | — | Boston Red Sox | Boston Red Sox signed free agent C Frederik Jimenez to a minor league contract. |
| Dec 9, 2022 | Signed as free agent | Jake Lamb | — | Los Angeles Angels | Los Angeles Angels signed free agent 3B Jake Lamb to a minor league contract. |
| Dec 9, 2022 | Signed as free agent | Alvin Nova | — | Athletics | Oakland Athletics signed free agent RHP Alvin Nova to a minor league contract. |
| Dec 9, 2022 | Signed as free agent | Carlos Blanco | — | Tampa Bay Rays | Tampa Bay Rays signed free agent C Carlos Blanco to a minor league contract. |
| Dec 8, 2022 | Trade | Unnamed | Tampa Bay Rays | Colorado Rockies | Colorado Rockies traded RHP Kevin Kelly to Tampa Bay Rays for cash. |
| Dec 8, 2022 | Signed as free agent | Trea Turner | — | Philadelphia Phillies | Philadelphia Phillies signed free agent SS Trea Turner. |
| Dec 8, 2022 | Signed as free agent | Chris Martin | — | Boston Red Sox | Boston Red Sox signed free agent RHP Chris Martin. |
| Dec 8, 2022 | Trade | Blake Sabol | Cincinnati Reds | San Francisco Giants | Cincinnati Reds traded C Blake Sabol to San Francisco Giants. |
| Dec 8, 2022 | Trade | Frankie Tostado | Seattle Mariners | Washington Nationals | Seattle Mariners traded RF Frankie Tostado to Washington Nationals. |
| Dec 8, 2022 | Signed as free agent | Diego Rincones | — | Detroit Tigers | Detroit Tigers signed free agent RF Diego Rincones to a minor league contract. |
| Dec 8, 2022 | Signed as free agent | Art Warren | — | New York Yankees | New York Yankees signed free agent RHP Art Warren to a minor league contract. |
| Dec 8, 2022 | Signed as free agent | Rodolfo Durán | — | New York Yankees | New York Yankees signed free agent C Rodolfo Durán to a minor league contract. |
| Dec 8, 2022 | Signed as free agent | Zac Houston | — | New York Yankees | New York Yankees signed free agent RHP Zac Houston to a minor league contract. |
| Dec 8, 2022 | Signed as free agent | Lisandro Santos | — | New York Yankees | New York Yankees signed free agent LHP Lisandro Santos to a minor league contract. |
| Dec 8, 2022 | Signed as free agent | Jamie Westbrook | — | New York Yankees | New York Yankees signed free agent 2B Jamie Westbrook to a minor league contract. |
| Dec 8, 2022 | Signed as free agent | Henry Henry | — | San Diego Padres | San Diego Padres signed free agent RHP Henry Henry to a minor league contract. |
| Dec 8, 2022 | Signed as free agent | Michael Flynn | — | Seattle Mariners | Seattle Mariners signed free agent RHP Michael Flynn to a minor league contract. |
| Dec 8, 2022 | Signed as free agent | Demarcus Evans | — | New York Yankees | New York Yankees signed free agent RHP Demarcus Evans to a minor league contract. |
| Dec 8, 2022 | Signed as free agent | Jeremy Walker | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RHP Jeremy Walker to a minor league contract and invited him to spring training. |
| Dec 7, 2022 | Trade | Brooks Raley | Tampa Bay Rays | New York Mets | Tampa Bay Rays traded LHP Brooks Raley to New York Mets for LHP Keyshawn Askew. |
| Dec 7, 2022 | Signed as free agent | Justin Verlander | — | New York Mets | New York Mets signed free agent RHP Justin Verlander. |
| Dec 7, 2022 | Trade | Joe Jiménez | Detroit Tigers | Atlanta Braves | Detroit Tigers traded RHP Joe Jiménez and cash to Atlanta Braves for 3B Justyn-Henry Malloy and LHP Jake Higginbotham. |
| Dec 7, 2022 | Signed as free agent | David García | — | Texas Rangers | Texas Rangers signed free agent C David García to a minor league contract. |
| Dec 7, 2022 | Signed as free agent | Silvino Bracho | — | Cincinnati Reds | Cincinnati Reds signed free agent RHP Silvino Bracho to a minor league contract and invited him to spring training. |
| Dec 7, 2022 | Trade | Jake Mangum | New York Mets | Miami Marlins | New York Mets traded CF Jake Mangum to Miami Marlins. |
| Dec 7, 2022 | Signed as free agent | Jason Heyward | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RF Jason Heyward to a minor league contract. |
| Dec 7, 2022 | Signed as free agent | Edwarli Brioso | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent SS Edwarli Brioso to a minor league contract. |
| Dec 7, 2022 | Signed as free agent | Jonawel Valdez | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent RHP Jonawel Valdez to a minor league contract. |
| Dec 7, 2022 | Signed as free agent | Matt Eckelman | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent RHP Matt Eckelman to a minor league contract. |
| Dec 6, 2022 | Signed as free agent | Chuckie Robinson | — | Cincinnati Reds | Cincinnati Reds signed free agent C Chuckie Robinson to a minor league contract and invited him to spring training. |
| Dec 6, 2022 | Signed as free agent | Jared Solomon | — | Cincinnati Reds | Cincinnati Reds signed free agent RHP Jared Solomon to a minor league contract and invited him to spring training. |
| Dec 6, 2022 | Signed as free agent | Nomar Mazara | — | Baltimore Orioles | Baltimore Orioles signed free agent RF Nomar Mazara to a minor league contract. |
| Dec 6, 2022 | Trade | Chad Smith | Colorado Rockies | Athletics | Colorado Rockies traded RHP Chad Smith to Oakland Athletics for RHP Jeff Criswell. |
| Dec 6, 2022 | Signed as free agent | Jhonny Pereda | — | Cincinnati Reds | Cincinnati Reds signed free agent C Jhonny Pereda to a minor league contract and invited him to spring training. |
| Dec 6, 2022 | Signed as free agent | Guillo Zuñiga | — | St. Louis Cardinals | St. Louis Cardinals signed free agent RHP Guillermo Zuniga. |
| Dec 6, 2022 | Signed as free agent | Mitch Haniger | — | San Francisco Giants | San Francisco Giants signed free agent RF Mitch Haniger. |
| Dec 6, 2022 | Signed as free agent | Josh Lester | — | Baltimore Orioles | Baltimore Orioles signed free agent 3B Josh Lester to a minor league contract. |
| Dec 5, 2022 | Signed as free agent | Clayton Kershaw | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent LHP Clayton Kershaw, and. |
| Dec 5, 2022 | Signed as free agent | Ofreidy Gómez | — | Baltimore Orioles | Baltimore Orioles signed free agent RHP Ofreidy Gómez to a minor league contract. |
| Dec 5, 2022 | Signed as free agent | Carlos Estévez | — | Los Angeles Angels | Los Angeles Angels signed free agent RHP Carlos Estévez. |
| Dec 5, 2022 | Signed as free agent | Kyle Gibson | — | Baltimore Orioles | Baltimore Orioles signed free agent RHP Kyle Gibson. |
| Dec 5, 2022 | Signed as free agent | Joe Hudson | — | Atlanta Braves | Atlanta Braves signed free agent C Joe Hudson to a minor league contract. |
| Dec 5, 2022 | Signed as free agent | Hudson Potts | — | Atlanta Braves | Atlanta Braves signed free agent 3B Hudson Potts to a minor league contract. |
| Dec 5, 2022 | Signed as free agent | Norwith Gudiño | — | Boston Red Sox | Boston Red Sox signed free agent RHP Norwith Gudino to a minor league contract. |
| Dec 5, 2022 | Signed as free agent | Brailyn Marquez | — | Chicago Cubs | Chicago Cubs signed free agent LHP Brailyn Marquez to a minor league contract. |
| Dec 5, 2022 | Signed as free agent | Brenan Hanifee | — | Detroit Tigers | Detroit Tigers signed free agent RHP Brenan Hanifee to a minor league contract. |
| Dec 5, 2022 | Signed as free agent | César Valdez | — | Los Angeles Angels | Los Angeles Angels signed free agent RHP César Valdez to a minor league contract. |
| Dec 5, 2022 | Signed as free agent | Austin Allen | — | Miami Marlins | Miami Marlins signed free agent C Austin Allen to a minor league contract. |
| Dec 5, 2022 | Signed as free agent | Adonis Medina | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Adonis Medina to a minor league contract. |
| Dec 5, 2022 | Signed as free agent | Carlos Luna | — | Minnesota Twins | Minnesota Twins signed free agent RHP Carlos Luna to a minor league contract. |
| Dec 5, 2022 | Signed as free agent | Tyler White | — | Minnesota Twins | Minnesota Twins signed free agent 1B Tyler White to a minor league contract. |
| Dec 5, 2022 | Signed as free agent | Tommy Hunter | — | New York Mets | New York Mets signed free agent RHP Tommy Hunter to a minor league contract. |
| Dec 5, 2022 | Signed as free agent | Sean Reid-Foley | — | New York Mets | New York Mets signed free agent RHP Sean Reid-Foley to a minor league contract. |
| Dec 5, 2022 | Signed as free agent | David Dahl | — | San Diego Padres | San Diego Padres signed free agent LF David Dahl to a minor league contract. |
| Dec 5, 2022 | Signed as free agent | Blake Weiman | — | Seattle Mariners | Seattle Mariners signed free agent LHP Blake Weiman to a minor league contract. |
| Dec 5, 2022 | Signed as free agent | Donovan Walton | — | San Francisco Giants | San Francisco Giants signed free agent 2B Donovan Walton to a minor league contract. |
| Dec 5, 2022 | Signed as free agent | Franklin Barreto | — | Washington Nationals | Washington Nationals signed free agent 2B Franklin Barreto to a minor league contract. |
| Dec 4, 2022 | Signed as free agent | Meibrys Viloria | — | Cleveland Guardians | Cleveland Guardians signed free agent C Meibrys Viloria to a minor league contract and invited him to spring training. |
| Dec 4, 2022 | Signed as free agent | Mike Clevinger | — | Chicago White Sox | Chicago White Sox signed free agent RHP Mike Clevinger. |
| Dec 2, 2022 | Signed as free agent | Franchy Cordero | — | Baltimore Orioles | Baltimore Orioles signed free agent CF Franchy Cordero to a minor league contract. |
| Dec 2, 2022 | Signed as free agent | Miguel Castro | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Miguel Castro. |
| Dec 2, 2022 | Trade | Jesse Winker | Seattle Mariners | Milwaukee Brewers | Milwaukee Brewers traded 2B Kolten Wong and cash to Seattle Mariners for LF Jesse Winker and 3B Abraham Toro. |
| Dec 2, 2022 | Signed as free agent | Jacob deGrom | — | Texas Rangers | Texas Rangers signed free agent RHP Jacob deGrom. |
| Dec 2, 2022 | Signed as free agent | Julio E. Rodriguez | — | Detroit Tigers | Detroit Tigers signed free agent C Julio E. Rodriguez to a minor league contract. |
| Dec 2, 2022 | Signed as free agent | Joel Canizalez | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP Joel Canizalez to a minor league contract. |
| Dec 1, 2022 | Signed as free agent | Adrian Santana | — | Chicago Cubs | Chicago Cubs signed free agent RHP Adrian Santana to a minor league contract. |
| Dec 1, 2022 | Signed as free agent | Anthony Gose | — | Cleveland Guardians | Cleveland Guardians signed free agent CF Anthony Gose to a minor league contract and invited him to spring training. |
| Dec 1, 2022 | Signed as free agent | Shelby Miller | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Shelby Miller. |
| Dec 1, 2022 | Signed as free agent | Austin Brice | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Austin Brice to a minor league contract. |
| Dec 1, 2022 | Signed as free agent | Alex De Goti | — | Miami Marlins | Miami Marlins signed free agent SS Alex De Goti to a minor league contract. |
| Dec 1, 2022 | Signed as free agent | Jimmy Yacabonis | — | New York Mets | New York Mets signed free agent RHP Jimmy Yacabonis to a minor league contract. |
| Dec 1, 2022 | Signed as free agent | Shawn Ross | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent SS Shawn Ross to a minor league contract. |
| Dec 1, 2022 | Signed as free agent | Riley Unroe | — | Seattle Mariners | Seattle Mariners signed free agent 2B Riley Unroe to a minor league contract. |
| Dec 1, 2022 | Signed as free agent | Lucas Jacobsen | — | Texas Rangers | Texas Rangers signed free agent LHP Lucas Jacobsen to a minor league contract. |
| Dec 1, 2022 | Signed as free agent | Ronald Herrera | — | Washington Nationals | Washington Nationals signed free agent RHP Ronald Herrera to a minor league contract. |
| Dec 1, 2022 | Signed as free agent | Erick Mejia | — | Washington Nationals | Washington Nationals signed free agent SS Erick Mejia to a minor league contract. |
| Dec 1, 2022 | Signed as free agent | Tito Polo | — | Washington Nationals | Washington Nationals signed free agent CF Tito Polo to a minor league contract. |
| Dec 1, 2022 | Signed as free agent | Leonel Valera | — | Washington Nationals | Washington Nationals signed free agent SS Leonel Valera to a minor league contract. |
| Dec 1, 2022 | Signed as free agent | Jesus Polanco | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RHP Jesus Polanco to a minor league contract. |
| Nov 30, 2022 | Signed as free agent | Trevor Gott | — | Seattle Mariners | Seattle Mariners signed free agent RHP Trevor Gott. |
| Nov 30, 2022 | Signed as free agent | Josbeiker Parra | — | Detroit Tigers | Detroit Tigers signed free agent RHP Josbeiker Parra to a minor league contract. |
| Nov 29, 2022 | Signed as free agent | Carlos Santana | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent 1B Carlos Santana. |
| Nov 29, 2022 | Signed as free agent | Jeimer Candelario | — | Washington Nationals | Washington Nationals signed free agent 3B Jeimer Candelario. |
| Nov 29, 2022 | Signed as free agent | Stone Garrett | — | Washington Nationals | Washington Nationals signed free agent CF Stone Garrett. |
| Nov 29, 2022 | Signed as free agent | Chris Devenski | — | Los Angeles Angels | Los Angeles Angels signed free agent RHP Chris Devenski to a minor league contract. |
| Nov 28, 2022 | Signed as free agent | Luke Maile | — | Cincinnati Reds | Cincinnati Reds signed free agent C Luke Maile. |
| Nov 28, 2022 | Signed as free agent | José Abreu | — | Houston Astros | Houston Astros signed free agent 1B José Abreu. |
| Nov 28, 2022 | Signed as free agent | Nash Walters | — | Los Angeles Angels | Los Angeles Angels signed free agent RHP Nash Walters to a minor league contract. |
| Nov 24, 2022 | Signed as free agent | Jan Pierre Garcia | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Jan Pierre Garcia to a minor league contract. |
| Nov 24, 2022 | Signed as free agent | Unnamed | — | Atlanta Braves | Atlanta Braves signed free agent RHP Styven Francisco to a minor league contract. |
| Nov 24, 2022 | Signed as free agent | Styven Paez | — | Atlanta Braves | Atlanta Braves signed free agent RHP Styven Paez to a minor league contract. |
| Nov 23, 2022 | Trade | Janson Junk | Los Angeles Angels | Milwaukee Brewers | Milwaukee Brewers traded RF Hunter Renfroe to Los Angeles Angels for RHP Janson Junk, RHP Elvis Peguero and LHP Adam Seminaris. |
| Nov 23, 2022 | Signed as free agent | Joely Rodríguez | — | Boston Red Sox | Boston Red Sox signed free agent LHP Joely Rodriguez. |
| Nov 23, 2022 | Signed as free agent | Zach Muckenhirn | — | New York Mets | New York Mets signed free agent LHP Zach Muckenhirn to a minor league contract and invited him to spring training. |
| Nov 23, 2022 | Signed as free agent | Denyi Reyes | — | New York Mets | New York Mets signed free agent RHP Denyi Reyes to a minor league contract and invited him to spring training. |
| Nov 23, 2022 | Signed as free agent | Blake Perkins | — | Milwaukee Brewers | Milwaukee Brewers signed free agent CF Blake Perkins. |
| Nov 23, 2022 | Trade | Inmer Lobo | Boston Red Sox | Pittsburgh Pirates | Pittsburgh Pirates traded SS Hoy Park to Boston Red Sox for LHP Inmer Lobo. |
| Nov 23, 2022 | Signed as free agent | Michael Papierski | — | Detroit Tigers | Detroit Tigers signed free agent C Michael Papierski to a minor league contract. |
| Nov 23, 2022 | Signed as free agent | Edgardo Castro | — | New York Mets | New York Mets signed free agent RHP Edgardo Castro to a minor league contract. |
| Nov 23, 2022 | Trade | Inmer Lobo | Boston Red Sox | Pittsburgh Pirates | Boston Red Sox traded LHP Inmer Lobo to Pittsburgh Pirates. |
| Nov 22, 2022 | Signed as free agent | Allan Cerda | — | Cincinnati Reds | Cincinnati Reds signed free agent OF Allan Cerda to a minor league contract and invited him to spring training. |
| Nov 22, 2022 | Signed as free agent | Daniel Duarte | — | Cincinnati Reds | Cincinnati Reds signed free agent RHP Daniel Duarte to a minor league contract and invited him to spring training. |
| Nov 22, 2022 | Signed as free agent | Dixon Machado | — | Houston Astros | Houston Astros signed free agent 2B Dixon Machado to a minor league contract and invited him to spring training. |
| Nov 22, 2022 | Signed as free agent | Nick Martinez | — | San Diego Padres | San Diego Padres signed free agent RHP Nick Martinez, and. |
| Nov 22, 2022 | Signed as free agent | Brooks Wilson | — | Atlanta Braves | Atlanta Braves signed free agent RHP Brooks Wilson to a minor league contract and invited him to spring training. |
| Nov 22, 2022 | Signed as free agent | Narciso Crook | — | Boston Red Sox | Boston Red Sox signed free agent CF Narciso Crook to a minor league contract. |
| Nov 22, 2022 | Signed as free agent | Nate Fisher | — | Chicago White Sox | Chicago White Sox signed free agent LHP Nate Fisher to a minor league contract and invited him to spring training. |
| Nov 22, 2022 | Signed as free agent | Chad Wallach | — | Los Angeles Angels | Los Angeles Angels signed free agent C Chad Wallach to a minor league contract. |
| Nov 22, 2022 | Signed as free agent | Dylan Bice | — | Miami Marlins | Miami Marlins signed free agent RHP Dylan Bice to a minor league contract. |
| Nov 22, 2022 | Signed as free agent | Elliot Soto | — | Minnesota Twins | Minnesota Twins signed free agent SS Elliot Soto to a minor league contract. |
| Nov 22, 2022 | Signed as free agent | Shervyen Newton | — | Philadelphia Phillies | Philadelphia Phillies signed free agent SS Shervyen Newton to a minor league contract. |
| Nov 22, 2022 | Signed as free agent | José Rodríguez | — | Seattle Mariners | Seattle Mariners signed free agent RHP Jose Rodriguez to a minor league contract. |
| Nov 22, 2022 | Signed as free agent | Hobie Harris | — | Washington Nationals | Washington Nationals signed free agent RHP Hobie Harris to a minor league contract. |
| Nov 22, 2022 | Signed as free agent | Derek Hill | — | Washington Nationals | Washington Nationals signed free agent CF Derek Hill to a minor league contract. |
| Nov 22, 2022 | Signed as free agent | Matt Koch | — | Colorado Rockies | Colorado Rockies signed free agent RHP Matt Koch to a minor league contract. |
| Nov 22, 2022 | Signed as free agent | Jonathan Holder | — | Los Angeles Angels | Los Angeles Angels signed free agent RHP Jonathan Holder to a minor league contract. |
| Nov 22, 2022 | Signed as free agent | Jacob Webb | — | Los Angeles Angels | Los Angeles Angels signed free agent RHP Jacob Webb to a minor league contract. |
| Nov 22, 2022 | Signed as free agent | Jasseel De La Cruz | — | Athletics | Oakland Athletics signed free agent RHP Jasseel De La Cruz to a minor league contract. |
| Nov 22, 2022 | Signed as free agent | Augusto Mendieta | — | Kansas City Royals | Kansas City Royals signed free agent RHP Augusto Mendieta to a minor league contract. |
| Nov 21, 2022 | Signed as free agent | Damian Jimenez | — | Kansas City Royals | Kansas City Royals signed free agent RHP Damian Jimenez to a minor league contract. |
| Nov 21, 2022 | Signed as free agent | Marvin Rojas | — | Kansas City Royals | Kansas City Royals signed free agent RHP Marvin Rojas to a minor league contract. |
| Nov 21, 2022 | Signed as free agent | Julio Rosario | — | Kansas City Royals | Kansas City Royals signed free agent RHP Julio Rosario to a minor league contract. |
| Nov 21, 2022 | Signed as free agent | Mark Payton | — | Chicago White Sox | Chicago White Sox signed free agent CF Mark Payton to a minor league contract. |
| Nov 21, 2022 | Signed as free agent | Brendon Davis | — | Detroit Tigers | Detroit Tigers signed free agent SS Brendon Davis to a minor league contract. |
| Nov 21, 2022 | Signed as free agent | Miguel Díaz | — | Detroit Tigers | Detroit Tigers signed free agent RHP Miguel Diaz to a minor league contract. |
| Nov 21, 2022 | Signed as free agent | Geoff Hartlieb | — | Miami Marlins | Miami Marlins signed free agent RHP Geoff Hartlieb to a minor league contract. |
| Nov 21, 2022 | Signed as free agent | Efrain Contreras | — | San Diego Padres | San Diego Padres signed free agent RHP Efrain Contreras to a minor league contract. |
| Nov 20, 2022 | Signed as free agent | Alan Rangel | — | Atlanta Braves | Atlanta Braves signed free agent RHP Alan Rangel to a minor league contract. |
| Nov 19, 2022 | Signed as free agent | Nick Howard | — | Cincinnati Reds | Cincinnati Reds signed free agent RHP Nick Howard to a minor league contract. |
| Nov 19, 2022 | Signed as free agent | Breilin Arredondo | — | Boston Red Sox | Boston Red Sox signed free agent RHP Breilin Arredondo to a minor league contract. |
| Nov 19, 2022 | Signed as free agent | Sam Delaplane | — | San Francisco Giants | San Francisco Giants signed free agent RHP Sam Delaplane to a minor league contract. |
| Nov 19, 2022 | Signed as free agent | Mauricio Llovera | — | San Francisco Giants | San Francisco Giants signed free agent RHP Mauricio Llovera to a minor league contract. |
| Nov 19, 2022 | Signed as free agent | Drew Strotman | — | San Francisco Giants | San Francisco Giants signed free agent RHP Drew Strotman to a minor league contract. |
| Nov 19, 2022 | Signed as free agent | Colton Welker | — | San Francisco Giants | San Francisco Giants signed free agent 3B Colton Welker to a minor league contract. |
| Nov 19, 2022 | Signed as free agent | Vinny Capra | — | Toronto Blue Jays | Toronto Blue Jays signed free agent SS Vinny Capra to a minor league contract. |
| Nov 18, 2022 | Signed as free agent | Óscar Mercado | — | St. Louis Cardinals | St. Louis Cardinals signed free agent CF Oscar Mercado to a minor league contract. |
| Nov 18, 2022 | Signed as free agent | Taylor Motter | — | St. Louis Cardinals | St. Louis Cardinals signed free agent 2B Taylor Motter to a minor league contract. |
| Nov 18, 2022 | Signed as free agent | Juniel Querecuto | — | St. Louis Cardinals | St. Louis Cardinals signed free agent 3B Juniel Querecuto to a minor league contract. |
| Nov 18, 2022 | Signed as free agent | Logan Sawyer | — | St. Louis Cardinals | St. Louis Cardinals signed free agent RHP Logan Sawyer to a minor league contract. |
| Nov 18, 2022 | Trade | Unnamed | New York Mets | Miami Marlins | Miami Marlins traded RHP Elieser Hernandez and RHP Jeff Brigham to New York Mets for RHP Franklin Sanchez and Player To Be Named Later. |
| Nov 18, 2022 | Trade | Alejandro Hidalgo | Los Angeles Angels | Minnesota Twins | Minnesota Twins traded 3B Gio Urshela to Los Angeles Angels for RHP Alejandro Hidalgo. |
| Nov 18, 2022 | Trade | Javy Guerra | Tampa Bay Rays | Milwaukee Brewers | Tampa Bay Rays traded RHP Javy Guerra to Milwaukee Brewers for Player To Be Named Later. |
| Nov 18, 2022 | Trade | Kyle Farmer | Cincinnati Reds | Minnesota Twins | Cincinnati Reds traded 2B Kyle Farmer to Minnesota Twins for RHP Casey Legumina. |
| Nov 18, 2022 | Trade | Kevin Newman | Pittsburgh Pirates | Cincinnati Reds | Pittsburgh Pirates traded SS Kevin Newman to Cincinnati Reds for RHP Dauri Moreta. |
| Nov 18, 2022 | Signed as free agent | Joseph Yabbour | — | Seattle Mariners | Seattle Mariners signed free agent RHP Joseph Yabbour to a minor league contract. |
| Nov 17, 2022 | Signed as free agent | Robert Suarez | — | San Diego Padres | San Diego Padres signed free agent RHP Robert Suarez. |
| Nov 17, 2022 | Released | Kirk McCarty | — | Cleveland Guardians | Cleveland Guardians released LHP Kirk McCarty. |
| Nov 17, 2022 | Trade | Kyle Lewis | Seattle Mariners | Arizona Diamondbacks | Seattle Mariners traded CF Kyle Lewis to Arizona Diamondbacks for C Cooper Hummel. |
| Nov 17, 2022 | Signed as free agent | Edgar Moreta | — | New York Mets | New York Mets signed free agent RHP Edgar Moreta to a minor league contract. |
| Nov 16, 2022 | Trade | Erik Swanson | Seattle Mariners | Toronto Blue Jays | Toronto Blue Jays traded LF Teoscar Hernandez to Seattle Mariners for LHP Adam Macko and RHP Erik Swanson. |
| Nov 16, 2022 | Signed as free agent | Austin Davis | — | Houston Astros | Houston Astros signed free agent LHP Austin Davis to a minor league contract and invited him to spring training. |
| Nov 16, 2022 | Released | Sebastián Rivero | — | Kansas City Royals | Kansas City Royals released C Sebastian Rivero. |
| Nov 16, 2022 | Released | Jeremy Beasley | — | Pittsburgh Pirates | Pittsburgh Pirates released RHP Jeremy Beasley. |
| Nov 16, 2022 | Signed as free agent | John Hicks | — | Philadelphia Phillies | Philadelphia Phillies signed free agent C John Hicks to a minor league contract. |
| Nov 16, 2022 | Signed as free agent | Kenny Hernandez | — | St. Louis Cardinals | St. Louis Cardinals signed free agent LHP Kenny Hernandez to a minor league contract. |
| Nov 15, 2022 | Signed as free agent | Unnamed | — | Houston Astros | Houston Astros signed free agent RHP Rafael Montero, and. |
| Nov 15, 2022 | Trade | Alfredo Zarraga | Chicago Cubs | Tampa Bay Rays | Tampa Bay Rays traded 2B Miles Mastrobuoni to Chicago Cubs for RHP Alfredo Zarraga. |
| Nov 15, 2022 | Signed as free agent | Unnamed | — | Texas Rangers | Texas Rangers signed free agent LHP Martín Pérez, and. |
| Nov 15, 2022 | Trade | Unnamed | Atlanta Braves | Texas Rangers | Texas Rangers traded RHP Dennis Santana to Atlanta Braves for cash. |
| Nov 15, 2022 | Trade | Steele Walker | San Francisco Giants | Detroit Tigers | San Francisco Giants traded OF Steele Walker to Detroit Tigers for cash. |
| Nov 15, 2022 | Trade | Tristan Peters | San Francisco Giants | Tampa Bay Rays | Tampa Bay Rays traded 2B Brett Wisely to San Francisco Giants for OF Tristan Peters. |
| Nov 15, 2022 | Signed as free agent | Unnamed | — | San Francisco Giants | San Francisco Giants signed free agent CF Joc Pederson, and. |
| Nov 15, 2022 | Signed as free agent | Unnamed | — | New York Yankees | New York Yankees signed free agent 1B Anthony Rizzo, and. |
| Nov 15, 2022 | Trade | Ross Carver | Arizona Diamondbacks | Cleveland Guardians | Cleveland Guardians traded RHP Carlos Vargas to Arizona Diamondbacks for RHP Ross Carver. |
| Nov 15, 2022 | Released | Foster Griffin | — | Toronto Blue Jays | Toronto Blue Jays released LHP Foster Griffin. |
| Nov 15, 2022 | Trade | Santiago Suarez | Miami Marlins | Tampa Bay Rays | Tampa Bay Rays traded RHP JT Chargois and SS Xavier Edwards to Miami Marlins for RHP Marcus Johnson and RHP Santiago Suarez. |
| Nov 15, 2022 | Trade | Juan Brito | Colorado Rockies | Cleveland Guardians | Cleveland Guardians traded 3B Nolan Jones to Colorado Rockies for SS Juan Brito. |
| Nov 15, 2022 | Signed as free agent | Bobby Milacki | — | San Diego Padres | San Diego Padres signed free agent RHP Bobby Milacki to a minor league contract. |
| Nov 14, 2022 | Released | Jason Heyward | — | Chicago Cubs | Chicago Cubs released RF Jason Heyward. |
| Nov 14, 2022 | Released | Seth Romero | — | Washington Nationals | Washington Nationals released LHP Seth Romero. |
| Nov 14, 2022 | Signed as free agent | Trenton Brooks | — | Athletics | Oakland Athletics signed free agent CF Trenton Brooks to a minor league contract. |
| Nov 14, 2022 | Signed as free agent | Rico Garcia | — | Athletics | Oakland Athletics signed free agent RHP Rico Garcia to a minor league contract. |
| Nov 14, 2022 | Signed as free agent | Pablo Reyes | — | Athletics | Oakland Athletics signed free agent 3B Pablo Reyes to a minor league contract. |
| Nov 14, 2022 | Signed as free agent | Idalberto Santiesteban | — | Milwaukee Brewers | Milwaukee Brewers signed free agent OF Idalberto Santiesteban to a minor league contract. |
| Nov 14, 2022 | Signed as free agent | Jermaine Palacios | — | Detroit Tigers | Detroit Tigers signed free agent SS Jermaine Palacios to a minor league contract. |
| Nov 12, 2022 | Signed as free agent | Jesse Chavez | — | Atlanta Braves | Atlanta Braves signed free agent RHP Jesse Chavez to a minor league contract. |
| Nov 11, 2022 | Signed as free agent | Unnamed | — | Colorado Rockies | Colorado Rockies signed free agent RHP José Ureña, and. |
| Nov 11, 2022 | Signed as free agent | Nick Anderson | — | Atlanta Braves | Atlanta Braves signed free agent RHP Nick Anderson. |
| Nov 11, 2022 | Signed as free agent | Jervis Alfaro | — | Cleveland Guardians | Cleveland Guardians signed free agent RHP Jervis Alfaro to a minor league contract. |
| Nov 10, 2022 | Trade | Unnamed | Cincinnati Reds | Texas Rangers | Texas Rangers traded 2B Nick Solak to Cincinnati Reds for cash. |
| Nov 10, 2022 | Signed as free agent | Kevin Herget | — | Cincinnati Reds | Cincinnati Reds signed free agent RHP Kevin Herget to a minor league contract. |
| Nov 10, 2022 | Trade | Ji Man Choi | Tampa Bay Rays | Pittsburgh Pirates | Tampa Bay Rays traded DH Ji-Man Choi to Pittsburgh Pirates for RHP Jack Hartman. |
| Nov 10, 2022 | Trade | Payton Henry | Miami Marlins | Milwaukee Brewers | Miami Marlins traded C Payton Henry to Milwaukee Brewers for RF Reminton Batista. |
| Nov 10, 2022 | Signed as free agent | Tobias Myers | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Tobias Myers to a minor league contract. |
| Nov 9, 2022 | Trade | José Fermín | Cleveland Guardians | St. Louis Cardinals | Cleveland Guardians traded SS Jose Fermin to St. Louis Cardinals for cash. |
| Nov 9, 2022 | Signed as free agent | Edwin Díaz | — | New York Mets | New York Mets signed free agent RHP Edwin Diaz. |
| Nov 9, 2022 | Trade | Unnamed | Seattle Mariners | Boston Red Sox | Boston Red Sox traded RHP Easton McGee to Seattle Mariners for cash. |
| Nov 9, 2022 | Signed as free agent | Elias Gonzalez | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Elias Gonzalez to a minor league contract. |
| Nov 9, 2022 | Trade | Unnamed | Atlanta Braves | Texas Rangers | Texas Rangers traded LHP Kolby Allard to Atlanta Braves for RHP Jake Odorizzi and cash. |
| Nov 9, 2022 | Signed as free agent | Wesley Moore | — | Philadelphia Phillies | Philadelphia Phillies signed free agent LHP Wesley Moore to a minor league contract. |
| Nov 8, 2022 | Signed as free agent | Christian Avendano | — | San Francisco Giants | San Francisco Giants signed free agent CF Christian Avendano to a minor league contract. |
| Nov 7, 2022 | Signed as free agent | Sean Doolittle | — | Washington Nationals | Washington Nationals signed free agent LHP Sean Doolittle and to a minor league contract and invited him to spring training. |
| Nov 6, 2022 | Trade | Unnamed | — | Atlanta Braves | Colorado Rockies traded RF Sam Hilliard and to Atlanta Braves for RHP Dylan Spain. |
| Nov 4, 2022 | Signed as free agent | Gilberto Batista | — | Boston Red Sox | Boston Red Sox signed free agent RHP Gilberto Batista to a minor league contract. |
| Nov 4, 2022 | Signed as free agent | Rancer Adon | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Rancer Adon to a minor league contract. |
| Nov 4, 2022 | Signed as free agent | Edgar Gomez | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Edgar Gomez to a minor league contract. |
| Nov 3, 2022 | Signed as free agent | Kevin Cron | — | Athletics | Oakland Athletics signed free agent 1B Kevin Cron to a minor league contract. |
| Oct 31, 2022 | Signed as free agent | Jarol Fernandez | — | Miami Marlins | Miami Marlins signed free agent LHP Jarol Fernandez to a minor league contract. |
| Oct 28, 2022 | Signed as free agent | Jose Subero | — | New York Mets | New York Mets signed free agent SS Jose Subero to a minor league contract. |
| Oct 25, 2022 | Signed as free agent | Jesus Valdez | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent 2B Jesus Valdez to a minor league contract. |
| Oct 24, 2022 | Signed as free agent | Josh Broughton | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent 3B Josh Broughton to a minor league contract. |
| Oct 22, 2022 | Signed as free agent | Erick Reynoso | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Erick Reynoso to a minor league contract. |
| Oct 21, 2022 | Signed as free agent | Miguel Del Pozo | — | Detroit Tigers | Detroit Tigers signed free agent LHP Miguel Del Pozo to a minor league contract. |
| Oct 21, 2022 | Signed as free agent | Angel Ferreras | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RHP Angel Ferreras to a minor league contract. |
| Oct 20, 2022 | Signed as free agent | Fabian Monsalve | — | Minnesota Twins | Minnesota Twins signed free agent RHP Fabian Monsalve to a minor league contract. |
| Oct 20, 2022 | Signed as free agent | Alejandro Ramirez | — | New York Mets | New York Mets signed free agent RHP Alejandro Ramirez to a minor league contract. |
| Oct 19, 2022 | Signed as free agent | Pedro Belisario | — | Texas Rangers | Texas Rangers signed free agent LHP Pedro Belisario to a minor league contract. |
| Oct 17, 2022 | Signed as free agent | Darrell Thompson | — | Milwaukee Brewers | Milwaukee Brewers signed free agent LHP Darrell Thompson to a minor league contract. |
| Oct 16, 2022 | Signed as free agent | Endrys Briceno | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Endrys Briceno to a minor league contract. |
| Oct 16, 2022 | Signed as free agent | Darcy Longstaff | — | Cincinnati Reds | Cincinnati Reds signed free agent RHP Darcy Longstaff to a minor league contract. |
| Oct 15, 2022 | Signed as free agent | Miguel Mejias | — | New York Mets | New York Mets signed free agent RHP Miguel Mejias to a minor league contract. |
| Oct 14, 2022 | Signed as free agent | Justin Ramirez | — | New York Mets | New York Mets signed free agent OF Justin Ramirez to a minor league contract. |
| Oct 14, 2022 | Signed as free agent | Yoralbert Cadiz | — | New York Mets | New York Mets signed free agent RHP Yoralbert Cadiz to a minor league contract. |
| Oct 14, 2022 | Signed as free agent | Railin Reyes | — | New York Mets | New York Mets signed free agent SS Railin Reyes to a minor league contract. |
| Oct 13, 2022 | Signed as free agent | Carlos Caro | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent IF Carlos Caro to a minor league contract. |
| Oct 13, 2022 | Signed as free agent | Nick Bautista III | — | Texas Rangers | Texas Rangers signed free agent RHP Nick Bautista III to a minor league contract. |
| Oct 5, 2022 | Signed as free agent | Daury Zapata | — | Atlanta Braves | Atlanta Braves signed free agent RHP Daury Zapata to a minor league contract. |
| Oct 2, 2022 | Signed as free agent | Kaleb Bowman | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Kaleb Bowman to a minor league contract. |
| Sep 30, 2022 | Signed as free agent | Jean Carlos Sió | — | San Francisco Giants | San Francisco Giants signed free agent IF Jean Carlos Sio to a minor league contract. |
| Sep 30, 2022 | Signed as free agent | Julio Marte | — | Houston Astros | Houston Astros signed free agent RHP Julio Marte to a minor league contract. |
| Sep 30, 2022 | Signed as free agent | Yannelbinson Lugo | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP Yannelbinson Lugo to a minor league contract. |
| Sep 30, 2022 | Signed as free agent | Yordi Mateo | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP Yordi Mateo to a minor league contract. |
| Sep 29, 2022 | Signed as free agent | Yency De Jesus | — | Minnesota Twins | Minnesota Twins signed free agent RHP Yency De Jesus to a minor league contract. |
| Sep 29, 2022 | Signed as free agent | Estarling Mercado | — | New York Mets | New York Mets signed free agent OF Estarling Mercado to a minor league contract. |
| Sep 28, 2022 | Signed as free agent | Yefri Martinez | — | Houston Astros | Houston Astros signed free agent RHP Yefri Martinez to a minor league contract. |
| Sep 24, 2022 | Released | Jake Lamb | — | Seattle Mariners | Seattle Mariners released 3B Jake Lamb. |
| Sep 23, 2022 | Signed as free agent | Jeremy Martinez | — | Houston Astros | Houston Astros signed free agent RHP Jeremy Martinez to a minor league contract. |
| Sep 22, 2022 | Signed as free agent | Randy Guzman | — | New York Mets | New York Mets signed free agent OF Randy Guzman to a minor league contract. |
| Sep 22, 2022 | Signed as free agent | Rainer Reyes | — | New York Mets | New York Mets signed free agent OF Rainer Reyes to a minor league contract. |
| Sep 21, 2022 | Signed as free agent | Kevin Plawecki | — | Texas Rangers | Texas Rangers signed free agent C Kevin Plawecki. |
| Sep 21, 2022 | Signed as free agent | Francis DIaz | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Francis DIaz to a minor league contract. |
| Sep 21, 2022 | Signed as free agent | Cristhofer Lozoya | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Cristhofer Lozoya to a minor league contract. |
| Sep 19, 2022 | Released | Kevin Plawecki | — | Boston Red Sox | Boston Red Sox released C Kevin Plawecki. |
| Sep 19, 2022 | Signed as free agent | Josnier Parra | — | Athletics | Oakland Athletics signed free agent RHP Josnier Parra to a minor league contract. |
| Sep 19, 2022 | Signed as free agent | Jose Pinto | — | Athletics | Oakland Athletics signed free agent RHP Jose Pinto to a minor league contract. |
| Sep 19, 2022 | Signed as free agent | Deiver Oliveros | — | Washington Nationals | Washington Nationals signed free agent RHP Deiver Oliveros to a minor league contract. |
| Sep 18, 2022 | Released | Frank Schwindel | — | Chicago Cubs | Chicago Cubs released 1B Frank Schwindel. |
| Sep 17, 2022 | Signed as free agent | Yonawil Florimon | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Yonawil Florimon to a minor league contract. |
| Sep 16, 2022 | Signed as free agent | Dannel Diaz | — | Washington Nationals | Washington Nationals signed free agent LHP Dannel Diaz to a minor league contract. |
| Sep 16, 2022 | Signed as free agent | Angel Pena | — | Washington Nationals | Washington Nationals signed free agent RHP Angel Pena to a minor league contract. |
| Sep 15, 2022 | Released | Jhoulys Chacín | — | Colorado Rockies | Colorado Rockies released RHP Jhoulys Chacin. |
| Sep 15, 2022 | Signed as free agent | David Avitia | — | Chicago Cubs | Chicago Cubs signed free agent C David Avitia to a minor league contract. |
| Sep 14, 2022 | Released | T.J. Zeuch | — | Cincinnati Reds | Cincinnati Reds released RHP T.J. Zeuch. |
| Sep 14, 2022 | Trade | Nicholas Northcut | Boston Red Sox | Cincinnati Reds | Boston Red Sox traded 3B Nicholas Northcut to Cincinnati Reds. |
| Sep 12, 2022 | Released | Albert Almora Jr. | — | Cincinnati Reds | Cincinnati Reds released CF Albert Almora Jr.. |
| Sep 12, 2022 | Signed as free agent | Yeral Vizcaino | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent OF Yeral Vizcaino to a minor league contract. |
| Sep 12, 2022 | Signed as free agent | Roberto Medina | — | Tampa Bay Rays | Tampa Bay Rays signed free agent LHP Roberto Medina to a minor league contract. |
| Sep 11, 2022 | Released | Jake McGee | — | Washington Nationals | Washington Nationals released LHP Jake McGee. |
| Sep 10, 2022 | Released | Dominic Leone | — | San Francisco Giants | San Francisco Giants released RHP Dominic Leone. |
| Sep 9, 2022 | Signed as free agent | DJ Peters | — | Washington Nationals | Washington Nationals signed free agent CF DJ Peters to a minor league contract. |
| Sep 9, 2022 | Signed as free agent | Daniel Ponce de Leon | — | Detroit Tigers | Detroit Tigers signed free agent RHP Daniel Ponce de Leon to a minor league contract. |
| Sep 9, 2022 | Signed as free agent | Juan Yunyet | — | Texas Rangers | Texas Rangers signed free agent LHP Juan Yunyet to a minor league contract. |
| Sep 8, 2022 | Released | Colin Moran | — | Cincinnati Reds | Cincinnati Reds released 3B Colin Moran. |
| Sep 8, 2022 | Signed as free agent | Shawndrick Oduber | — | Kansas City Royals | Kansas City Royals signed free agent RHP Shawndrick Oduber to a minor league contract. |
| Sep 7, 2022 | Released | Michael Pineda | — | Detroit Tigers | Detroit Tigers released RHP Michael Pineda. |
| Sep 7, 2022 | Signed as free agent | Juan Minaya | — | Minnesota Twins | Minnesota Twins signed free agent RHP Juan Minaya to a minor league contract. |
| Sep 7, 2022 | Released | Matt Wisler | — | Tampa Bay Rays | Tampa Bay Rays released RHP Matt Wisler. |
| Sep 7, 2022 | Signed as free agent | Eric Stamets | — | Toronto Blue Jays | Toronto Blue Jays signed free agent SS Eric Stamets to a minor league contract. |
| Sep 7, 2022 | Signed as free agent | Ismael Javier | — | San Diego Padres | San Diego Padres signed free agent IF Ismael Javier to a minor league contract. |
| Sep 7, 2022 | Signed as free agent | Juan Cota | — | Minnesota Twins | Minnesota Twins signed free agent RHP Juan Cota to a minor league contract. |
| Sep 5, 2022 | Released | Eddy Alvarez | — | Los Angeles Dodgers | Los Angeles Dodgers released SS Eddy Alvarez. |
| Sep 5, 2022 | Signed as free agent | Harrison Ruiz | — | Cleveland Guardians | Cleveland Guardians signed free agent RHP Harrison Ruiz to a minor league contract. |
| Sep 5, 2022 | Signed as free agent | Ryan Langford | — | Los Angeles Angels | Los Angeles Angels signed free agent RHP Ryan Langford to a minor league contract. |
| Sep 5, 2022 | Signed as free agent | Luis De La Cruz | — | Houston Astros | Houston Astros signed free agent RHP Luis De La Cruz to a minor league contract. |
| Sep 5, 2022 | Signed as free agent | Nick Horvath | — | Los Angeles Angels | Los Angeles Angels signed free agent CF Nick Horvath to a minor league contract. |
| Sep 4, 2022 | Trade | Nash Walters | Milwaukee Brewers | Los Angeles Angels | Milwaukee Brewers traded RHP Nash Walters to Los Angeles Angels for cash. |
| Sep 4, 2022 | Released | Dallas Keuchel | — | Texas Rangers | Texas Rangers released LHP Dallas Keuchel. |
| Sep 3, 2022 | Released | Noé Ramirez | — | Arizona Diamondbacks | Arizona Diamondbacks released RHP Noe Ramirez. |
| Sep 2, 2022 | Released | Niko Goodrum | — | Houston Astros | Houston Astros released 1B Niko Goodrum. |
| Sep 2, 2022 | Released | David McKay | — | Athletics | Oakland Athletics released RHP David McKay. |
| Sep 1, 2022 | Signed as free agent | Dawel Serda | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Dawel Serda to a minor league contract. |
| Sep 1, 2022 | Signed as free agent | Yoerny Junco | — | St. Louis Cardinals | St. Louis Cardinals signed free agent SS Yoerny Junco to a minor league contract. |
| Sep 1, 2022 | Signed as free agent | Matthew Boyd | — | Seattle Mariners | Seattle Mariners signed free agent LHP Matthew Boyd. |
| Aug 31, 2022 | Trade | Taylor Broadway | Chicago White Sox | Boston Red Sox | Chicago White Sox traded RHP Taylor Broadway to Boston Red Sox. |
| Aug 31, 2022 | Signed as free agent | Yeferson Silva | — | Athletics | Oakland Athletics signed free agent RHP Yeferson Silva to a minor league contract. |
| Aug 31, 2022 | Trade | Vinny Nittoli | Toronto Blue Jays | Philadelphia Phillies | Toronto Blue Jays traded RHP Vinny Nittoli to Philadelphia Phillies for C Karl Ellison. |
| Aug 31, 2022 | Signed as free agent | Tyler Duffey | — | New York Yankees | New York Yankees signed free agent RHP Tyler Duffey to a minor league contract. |
| Aug 31, 2022 | Released | Phil Gosselin | — | Los Angeles Angels | Los Angeles Angels released 2B Phil Gosselin. |
| Aug 31, 2022 | Trade | Edward Duran | Miami Marlins | Toronto Blue Jays | Miami Marlins traded C Edward Duran to Toronto Blue Jays. |
| Aug 31, 2022 | Signed as free agent | Jesús Aguilar | — | Baltimore Orioles | Baltimore Orioles signed free agent 1B Jesus Aguilar to a minor league contract. |
| Aug 31, 2022 | Trade | Lewis Brinson | Houston Astros | San Francisco Giants | Houston Astros traded CF Lewis Brinson to San Francisco Giants. |
| Aug 31, 2022 | Signed as free agent | Keone Kela | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Keone Kela to a minor league contract. |
| Aug 31, 2022 | Signed as free agent | Brad Peacock | — | Minnesota Twins | Minnesota Twins signed free agent RHP Brad Peacock to a minor league contract. |
| Aug 31, 2022 | Signed as free agent | Yannic Walther | — | Milwaukee Brewers | Milwaukee Brewers signed free agent C Yannic Walther to a minor league contract. |
| Aug 30, 2022 | Released | Max Schrock | — | Cincinnati Reds | Cincinnati Reds released 2B Max Schrock. |
| Aug 30, 2022 | Signed as free agent | Jacob Barnes | — | New York Yankees | New York Yankees signed free agent RHP Jacob Barnes to a minor league contract. |
| Aug 30, 2022 | Signed as free agent | Chi Chi González | — | New York Yankees | New York Yankees signed free agent RHP Chi Chi Gonzalez to a minor league contract. |
| Aug 30, 2022 | Signed as free agent | Wilking Rodríguez | — | New York Yankees | New York Yankees signed free agent RHP Wilking Rodriguez to a minor league contract. |
| Aug 30, 2022 | Signed as free agent | Jake Marisnick | — | Atlanta Braves | Atlanta Braves signed free agent CF Jake Marisnick to a minor league contract. |
| Aug 29, 2022 | Released | Jesse Chavez | — | Los Angeles Angels | Los Angeles Angels released RHP Jesse Chavez. |
| Aug 29, 2022 | Signed as free agent | Chris Devenski | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RHP Chris Devenski to a minor league contract. |
| Aug 29, 2022 | Released | Jesse Chavez | — | Los Angeles Angels | Los Angeles Angels released RHP Jesse Chavez. |
| Aug 29, 2022 | Released | Jesse Chavez | — | Los Angeles Angels | Los Angeles Angels released RHP Jesse Chavez. |
| Aug 28, 2022 | Signed as free agent | Anthony Banda | — | New York Yankees | New York Yankees signed free agent LHP Anthony Banda. |
| Aug 28, 2022 | Signed | Joe Lampe | — | Cleveland Guardians | Cleveland Guardians signed OF Joe Lampe. |
| Aug 28, 2022 | Signed as free agent | Ryan Burr | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP Ryan Burr to a minor league contract. |
| Aug 27, 2022 | Released | Chris Devenski | — | Arizona Diamondbacks | Arizona Diamondbacks released RHP Chris Devenski. |
| Aug 27, 2022 | Released | Jesús Aguilar | — | Miami Marlins | Miami Marlins released 1B Jesus Aguilar. |
| Aug 27, 2022 | Signed as free agent | Billy Hamilton | — | Minnesota Twins | Minnesota Twins signed free agent CF Billy Hamilton to a minor league contract. |
| Aug 27, 2022 | Signed as free agent | Chasen Shreve | — | New York Yankees | New York Yankees signed free agent LHP Chasen Shreve to a minor league contract. |
| Aug 27, 2022 | Signed as free agent | Chase Anderson | — | Cincinnati Reds | Cincinnati Reds signed free agent RHP Chase Anderson to a minor league contract. |
| Aug 26, 2022 | Released | Maikel Franco | — | Washington Nationals | Washington Nationals released 3B Maikel Franco. |
| Aug 26, 2022 | Signed as free agent | Logan Allen | — | Colorado Rockies | Colorado Rockies signed free agent LHP Logan Allen to a minor league contract. |
| Aug 26, 2022 | Signed as free agent | Andy Rodriguez | — | Texas Rangers | Texas Rangers signed free agent RHP Andy Rodriguez to a minor league contract. |
| Aug 25, 2022 | Signed as free agent | Michael Feliz | — | Minnesota Twins | Minnesota Twins signed free agent RHP Michael Feliz to a minor league contract. |
| Aug 25, 2022 | Signed as free agent | Ismael Cabral | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP Ismael Cabral to a minor league contract. |
| Aug 25, 2022 | Signed as free agent | Xavier Guillen | — | Tampa Bay Rays | Tampa Bay Rays signed free agent IF Xavier Guillen to a minor league contract. |
| Aug 25, 2022 | Signed as free agent | Jordi Infante | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP Jordi Infante to a minor league contract. |
| Aug 25, 2022 | Signed as free agent | Starlin Savinon | — | Tampa Bay Rays | Tampa Bay Rays signed free agent LHP Starlin Savinon to a minor league contract. |
| Aug 25, 2022 | Signed as free agent | Yereny Teus | — | Tampa Bay Rays | Tampa Bay Rays signed free agent LHP Yereny Teus to a minor league contract. |
| Aug 25, 2022 | Signed as free agent | Alexis Valdez | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP Alexis Valdez to a minor league contract. |
| Aug 25, 2022 | Signed as free agent | Unnamed | — | San Francisco Giants | San Francisco Giants signed free agent RHP Enmanuel Jimenez to a minor league contract. |
| Aug 24, 2022 | Signed as free agent | Riley Jepson | — | Chicago White Sox | Chicago White Sox signed free agent 1B Riley Jepson to a minor league contract. |
| Aug 24, 2022 | Signed as free agent | Jakson Reetz | — | Kansas City Royals | Kansas City Royals signed free agent C Jakson Reetz to a minor league contract. |
| Aug 24, 2022 | Signed as free agent | Pedro Mercedes | — | New York Mets | New York Mets signed free agent RHP Pedro Mercedes to a minor league contract. |
| Aug 23, 2022 | Signed as free agent | Tony Wolters | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent C Tony Wolters to a minor league contract. |
| Aug 23, 2022 | Signed as free agent | Stephen Piscotty | — | Cincinnati Reds | Cincinnati Reds signed free agent RF Stephen Piscotty to a minor league contract. |
| Aug 23, 2022 | Released | Garrett Richards | — | Texas Rangers | Texas Rangers released RHP Garrett Richards. |
| Aug 23, 2022 | Released | Nomar Mazara | — | San Diego Padres | San Diego Padres released RF Nomar Mazara. |
| Aug 23, 2022 | Signed | T.J. McFarland | — | St. Louis Cardinals | St. Louis Cardinals signed LHP T.J. McFarland. |
| Aug 23, 2022 | Signed as free agent | Dylan McCall | — | Detroit Tigers | Detroit Tigers signed free agent RHP Dylan McCall to a minor league contract. |
| Aug 23, 2022 | Signed as free agent | Chase Webster | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RHP Chase Webster to a minor league contract. |
| Aug 22, 2022 | Signed as free agent | Ken Giles | — | San Francisco Giants | San Francisco Giants signed free agent RHP Ken Giles to a minor league contract. |
| Aug 22, 2022 | Released | Wily Peralta | — | Detroit Tigers | Detroit Tigers released RHP Wily Peralta. |
| Aug 21, 2022 | Signed as free agent | Manuel Alvarez | — | New York Mets | New York Mets signed free agent RHP Manuel Alvarez to a minor league contract. |
| Aug 20, 2022 | Signed as free agent | Wilson Ramos | — | Texas Rangers | Texas Rangers signed free agent C Wilson Ramos to a minor league contract. |
| Aug 19, 2022 | Signed as free agent | Elvis Andrus | — | Chicago White Sox | Chicago White Sox signed free agent SS Elvis Andrus. |
| Aug 19, 2022 | Signed as free agent | Brandon Kintzler | — | San Diego Padres | San Diego Padres signed free agent RHP Brandon Kintzler to a minor league contract. |
| Aug 19, 2022 | Signed as free agent | Garrett Leonard | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Garrett Leonard to a minor league contract. |
| Aug 19, 2022 | Signed as free agent | Jordan Brink | — | Minnesota Twins | Minnesota Twins signed free agent RHP Jordan Brink to a minor league contract. |
| Aug 19, 2022 | Signed as free agent | Harrison Cohen | — | New York Yankees | New York Yankees signed free agent RHP Harrison Cohen to a minor league contract. |
| Aug 19, 2022 | Signed as free agent | Mason Vinyard | — | New York Yankees | New York Yankees signed free agent RHP Mason Vinyard to a minor league contract. |
| Aug 19, 2022 | Signed as free agent | Tommy Milone | — | Seattle Mariners | Seattle Mariners signed free agent LHP Tommy Milone to a minor league contract. |
| Aug 19, 2022 | Signed as free agent | Frederic Frias | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Frederic Frias to a minor league contract. |
| Aug 18, 2022 | Signed as free agent | Raynel Espinal | — | Cincinnati Reds | Cincinnati Reds signed free agent RHP Raynel Espinal to a minor league contract. |
| Aug 18, 2022 | Released | Tony Wolters | — | Los Angeles Dodgers | Los Angeles Dodgers released C Tony Wolters. |
| Aug 18, 2022 | Signed as free agent | Jhon Nunez | — | New York Mets | New York Mets signed free agent RHP Jhon Nunez to a minor league contract. |
| Aug 17, 2022 | Released | Elvis Andrus | — | Athletics | Oakland Athletics released SS Elvis Andrus. |
| Aug 16, 2022 | Released | Stephen Piscotty | — | Athletics | Oakland Athletics released RF Stephen Piscotty. |
| Aug 16, 2022 | Trade | Tyler White | Milwaukee Brewers | Atlanta Braves | Milwaukee Brewers traded 1B Tyler White to Atlanta Braves for cash. |
| Aug 16, 2022 | Signed as free agent | Mike Ford | — | Los Angeles Angels | Los Angeles Angels signed free agent 1B Mike Ford to a minor league contract. |
| Aug 16, 2022 | Signed as free agent | Tyler Duffey | — | Texas Rangers | Texas Rangers signed free agent RHP Tyler Duffey to a minor league contract. |
| Aug 16, 2022 | Signed as free agent | Travis Jankowski | — | New York Mets | New York Mets signed free agent CF Travis Jankowski to a minor league contract. |
| Aug 16, 2022 | Signed as free agent | Yoshi Tsutsugo | — | Toronto Blue Jays | Toronto Blue Jays signed free agent LF Yoshi Tsutsugo to a minor league contract. |
| Aug 15, 2022 | Signed as free agent | Alonzo Rubalcaba | — | Detroit Tigers | Detroit Tigers signed free agent C Alonzo Rubalcaba to a minor league contract. |
| Aug 15, 2022 | Signed as free agent | Bernie Orozco | — | Atlanta Braves | Atlanta Braves signed free agent RHP Bernie Orozco to a minor league contract. |
| Aug 15, 2022 | Signed as free agent | Abraham Gaitan | — | Cincinnati Reds | Cincinnati Reds signed free agent RHP Abraham Gaitan to a minor league contract. |
| Aug 15, 2022 | Signed as free agent | Christopher Vasquez | — | Milwaukee Brewers | Milwaukee Brewers signed free agent OF Christopher Vasquez to a minor league contract. |
| Aug 14, 2022 | Trade | Ricardo Sánchez | Philadelphia Phillies | Detroit Tigers | Philadelphia Phillies traded LHP Ricardo Sanchez to Detroit Tigers for cash. |
| Aug 14, 2022 | Signed as free agent | Derek Law | — | Cincinnati Reds | Cincinnati Reds signed free agent RHP Derek Law to a minor league contract. |
| Aug 14, 2022 | Released | Ken Giles | — | Seattle Mariners | Seattle Mariners released RHP Ken Giles. |
| Aug 13, 2022 | Signed as free agent | Caswell Smith | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Caswell Smith to a minor league contract. |
| Aug 13, 2022 | Signed as free agent | Grant Holmes | — | Atlanta Braves | Atlanta Braves signed free agent RHP Grant Holmes to a minor league contract. |
| Aug 13, 2022 | Signed as free agent | Ryan Hennen | — | Baltimore Orioles | Baltimore Orioles signed free agent LHP Ryan Hennen to a minor league contract. |
| Aug 12, 2022 | Released | T.J. McFarland | — | St. Louis Cardinals | St. Louis Cardinals released LHP T.J. McFarland. |
| Aug 12, 2022 | Signed as free agent | Jake McMahill | — | Cincinnati Reds | Cincinnati Reds signed free agent RHP Jake McMahill to a minor league contract. |
| Aug 12, 2022 | Signed as free agent | Lluveres Severino | — | Toronto Blue Jays | Toronto Blue Jays signed free agent RHP Lluveres Severino to a minor league contract. |
| Aug 11, 2022 | Released | Jed Lowrie | — | Athletics | Oakland Athletics released SS Jed Lowrie. |
| Aug 11, 2022 | Signed | Trey Braithwaite | — | Cincinnati Reds | Cincinnati Reds signed RHP Trey Braithwaite. |
| Aug 11, 2022 | Signed | Zach Maxwell | — | Cincinnati Reds | Cincinnati Reds signed RHP Zach Maxwell. |
| Aug 11, 2022 | Signed | Easton Sikorski | — | Cincinnati Reds | Cincinnati Reds signed RHP Easton Sikorski. |
| Aug 11, 2022 | Signed | Bryce Hubbart | — | Cincinnati Reds | Cincinnati Reds signed LHP Bryce Hubbart. |
| Aug 11, 2022 | Signed | Rob Hensey | — | Cincinnati Reds | Cincinnati Reds signed LHP Rob Hensey. |
| Aug 10, 2022 | Signed as free agent | Jack Noble | — | Minnesota Twins | Minnesota Twins signed free agent RHP Jack Noble to a minor league contract. |
| Aug 10, 2022 | Signed as free agent | Ricky Mineo | — | Minnesota Twins | Minnesota Twins signed free agent RHP Ricky Mineo to a minor league contract. |
| Aug 10, 2022 | Signed as free agent | Omari Daniel | — | Minnesota Twins | Minnesota Twins signed free agent SS Omari Daniel to a minor league contract. |
| Aug 10, 2022 | Signed as free agent | Jacob Edwards | — | Minnesota Twins | Minnesota Twins signed free agent LHP Jacob Edwards to a minor league contract. |
| Aug 10, 2022 | Released | Mike Ford | — | Atlanta Braves | Atlanta Braves released 1B Mike Ford. |
| Aug 10, 2022 | Released | Mike Ford | — | Atlanta Braves | Atlanta Braves released 1B Mike Ford. |
| Aug 10, 2022 | Signed as free agent | Josh Rogers | — | Miami Marlins | Miami Marlins signed free agent LHP Josh Rogers to a minor league contract. |
| Aug 10, 2022 | Released | Travis Jankowski | — | Seattle Mariners | Seattle Mariners released CF Travis Jankowski. |
| Aug 10, 2022 | Signed | Aidan Maldonado | — | Milwaukee Brewers | Milwaukee Brewers signed RHP Aidan Maldonado. |
| Aug 10, 2022 | Signed | Jacob Misiorowski | — | Milwaukee Brewers | Milwaukee Brewers signed RHP Jacob Misiorowski. |
| Aug 10, 2022 | Signed | Brian Fitzpatrick | — | Milwaukee Brewers | Milwaukee Brewers signed LHP Brian Fitzpatrick. |
| Aug 10, 2022 | Signed | Nate Peterson | — | Milwaukee Brewers | Milwaukee Brewers signed LHP Nate Peterson. |
| Aug 10, 2022 | Signed | Will Rudy | — | Milwaukee Brewers | Milwaukee Brewers signed RHP Will Rudy. |
| Aug 10, 2022 | Signed as free agent | Jonathan Beymer | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Jonathan Beymer to a minor league contract. |
| Aug 10, 2022 | Signed as free agent | Jeison Guzmán | — | Kansas City Royals | Kansas City Royals signed free agent SS Jeison Guzman to a minor league contract. |
| Aug 9, 2022 | Signed as free agent | Jackie Bradley Jr. | — | Toronto Blue Jays | Toronto Blue Jays signed free agent CF Jackie Bradley Jr.. |
| Aug 9, 2022 | Signed as free agent | Logan Adams | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Logan Adams to a minor league contract. |
| Aug 9, 2022 | Signed | Tyler Woessner | — | Milwaukee Brewers | Milwaukee Brewers signed RHP Tyler Woessner. |
| Aug 9, 2022 | Signed | Victor Mederos | — | Los Angeles Angels | Los Angeles Angels signed RHP Victor Mederos. |
| Aug 9, 2022 | Signed as free agent | Anthony Banda | — | Seattle Mariners | Seattle Mariners signed free agent LHP Anthony Banda to a minor league contract. |
| Aug 9, 2022 | Signed as free agent | Sterling Sharp | — | Boston Red Sox | Boston Red Sox signed free agent RHP Sterling Sharp to a minor league contract. |
| Aug 9, 2022 | Signed as free agent | Jeurys Familia | — | Boston Red Sox | Boston Red Sox signed free agent RHP Jeurys Familia to a minor league contract. |
| Aug 9, 2022 | Signed as free agent | Luke Bartnicki | — | New York Mets | New York Mets signed free agent LHP Luke Bartnicki to a minor league contract. |
| Aug 8, 2022 | Signed as free agent | John Klein | — | Minnesota Twins | Minnesota Twins signed free agent RHP John Klein to a minor league contract. |
| Aug 8, 2022 | Signed | Luke Adams | — | Milwaukee Brewers | Milwaukee Brewers signed 3B Luke Adams. |
| Aug 8, 2022 | Signed | Jalen Battles | — | Tampa Bay Rays | Tampa Bay Rays signed SS Jalen Battles. |
| Aug 8, 2022 | Signed | Ryan Cermak | — | Tampa Bay Rays | Tampa Bay Rays signed SS Ryan Cermak. |
| Aug 8, 2022 | Signed | Kamren James | — | Tampa Bay Rays | Tampa Bay Rays signed SS Kamren James. |
| Aug 8, 2022 | Signed | Brock Jones | — | Tampa Bay Rays | Tampa Bay Rays signed OF Brock Jones. |
| Aug 8, 2022 | Signed | Dom Keegan | — | Tampa Bay Rays | Tampa Bay Rays signed C Dominic Keegan. |
| Aug 8, 2022 | Signed | Blake Robertson | — | Tampa Bay Rays | Tampa Bay Rays signed 1B Blake Robertson. |
| Aug 8, 2022 | Signed | Chandler Simpson | — | Tampa Bay Rays | Tampa Bay Rays signed SS Chandler Simpson. |
| Aug 8, 2022 | Signed | Cole Patten | — | Detroit Tigers | Detroit Tigers signed RHP Cole Patten. |
| Aug 8, 2022 | Signed as free agent | Archer Brookman | — | Detroit Tigers | Detroit Tigers signed free agent C Archer Brookman to a minor league contract. |
| Aug 8, 2022 | Signed | Dom Johnson | — | Detroit Tigers | Detroit Tigers signed OF Dom Johnson. |
| Aug 8, 2022 | Signed | Nick Peoples | — | Washington Nationals | Washington Nationals signed OF Nick Peoples. |
| Aug 8, 2022 | Signed | Jake Bennett | — | Washington Nationals | Washington Nationals signed LHP Jake Bennett. |
| Aug 8, 2022 | Signed as free agent | Christian Ciuffetelli | — | Washington Nationals | Washington Nationals signed free agent RHP Christian Ciuffetelli to a minor league contract. |
| Aug 8, 2022 | Signed | Riley Cornelio | — | Washington Nationals | Washington Nationals signed RHP Riley Cornelio. |
| Aug 8, 2022 | Signed | Marquis Grissom Jr. | — | Washington Nationals | Washington Nationals signed RHP Marquis Grissom Jr.. |
| Aug 8, 2022 | Signed as free agent | Bubba Hall | — | Washington Nationals | Washington Nationals signed free agent RHP Bubba Hall to a minor league contract. |
| Aug 8, 2022 | Signed | Chance Huff | — | Washington Nationals | Washington Nationals signed RHP Chance Huff. |
| Aug 8, 2022 | Signed | Brad Lord | — | Washington Nationals | Washington Nationals signed RHP Brad Lord. |
| Aug 8, 2022 | Signed | Kyle Luckham | — | Washington Nationals | Washington Nationals signed RHP Kyle Luckham. |
| Aug 8, 2022 | Signed as free agent | Nick Pogue | — | Washington Nationals | Washington Nationals signed free agent RHP Nick Pogue to a minor league contract. |
| Aug 8, 2022 | Signed | Luke Young | — | Washington Nationals | Washington Nationals signed RHP Luke Young. |
| Aug 8, 2022 | Signed as free agent | Jaren Zinn | — | Washington Nationals | Washington Nationals signed free agent RHP Jaren Zinn to a minor league contract. |
| Aug 8, 2022 | Signed as free agent | Caleb Farmer | — | Washington Nationals | Washington Nationals signed free agent C Caleb Farmer to a minor league contract. |
| Aug 8, 2022 | Signed as free agent | Matt Suggs | — | Washington Nationals | Washington Nationals signed free agent C Matt Suggs to a minor league contract. |
| Aug 8, 2022 | Signed | Everett Cooper III | — | Washington Nationals | Washington Nationals signed SS Everett Cooper III. |
| Aug 8, 2022 | Signed | Blake Klassen | — | Washington Nationals | Washington Nationals signed 1B Blake Klassen. |
| Aug 8, 2022 | Signed | Nathaniel Ochoa Leyva | — | Washington Nationals | Washington Nationals signed SS Nathaniel Ochoa Leyva. |
| Aug 8, 2022 | Signed | Tyler Baca | — | Washington Nationals | Washington Nationals signed OF Tyler Baca. |
| Aug 8, 2022 | Signed | Brenner Cox | — | Washington Nationals | Washington Nationals signed OF Brenner Cox. |
| Aug 8, 2022 | Signed | Elijah Green | — | Washington Nationals | Washington Nationals signed OF Elijah Green. |
| Aug 8, 2022 | Signed | Johnathon Thomas | — | Washington Nationals | Washington Nationals signed OF Johnathon Thomas. |
| Aug 8, 2022 | Signed as free agent | Juan Mejia | — | Kansas City Royals | Kansas City Royals signed free agent RHP Juan Mejia to a minor league contract. |
| Aug 8, 2022 | Signed as free agent | Jared McKenzie | — | Washington Nationals | Washington Nationals signed free agent OF Jared McKenzie to a minor league contract. |
| Aug 7, 2022 | Released | Jake Marisnick | — | Pittsburgh Pirates | Pittsburgh Pirates released CF Jake Marisnick. |
| Aug 7, 2022 | Released | Tyler Duffey | — | Minnesota Twins | Minnesota Twins released RHP Tyler Duffey. |
| Aug 7, 2022 | Released | Andrelton Simmons | — | Chicago Cubs | Chicago Cubs released SS Andrelton Simmons. |
| Aug 7, 2022 | Signed | Matt Hickey | — | St. Louis Cardinals | St. Louis Cardinals signed RHP Matt Hickey. |
| Aug 7, 2022 | Signed | Blake Adams | — | Colorado Rockies | Colorado Rockies signed RHP Blake Adams. |
| Aug 7, 2022 | Signed | Javier Ramos | — | Colorado Rockies | Colorado Rockies signed RHP Javier Ramos. |
| Aug 7, 2022 | Signed | Ryan Ritter | — | Colorado Rockies | Colorado Rockies signed SS Ryan Ritter. |
| Aug 7, 2022 | Signed | Carlos Torres | — | Colorado Rockies | Colorado Rockies signed RHP Carlos Torres. |
| Aug 7, 2022 | Signed as free agent | Cole Stilwell | — | Colorado Rockies | Colorado Rockies signed free agent C Cole Stilwell to a minor league contract. |
| Aug 6, 2022 | Released | Odúbel Herrera | — | Philadelphia Phillies | Philadelphia Phillies released CF Odubel Herrera. |
| Aug 6, 2022 | Signed | Ben Brutti | — | Cincinnati Reds | Cincinnati Reds signed RHP Ben Brutti. |
| Aug 6, 2022 | Released | Jeurys Familia | — | Philadelphia Phillies | Philadelphia Phillies released RHP Jeurys Familia. |
| Aug 6, 2022 | Signed as free agent | Joe Joe Rodriguez | — | New York Mets | New York Mets signed free agent RHP Joe Joe Rodriguez to a minor league contract. |
| Aug 6, 2022 | Signed as free agent | Juanmi Vasquez | — | Toronto Blue Jays | Toronto Blue Jays signed free agent Juanmi Vasquez to a minor league contract. |
| Aug 5, 2022 | Released | Joe Smith | — | Minnesota Twins | Minnesota Twins released RHP Joe Smith. |
| Aug 5, 2022 | Released | Yoshi Tsutsugo | — | Pittsburgh Pirates | Pittsburgh Pirates released LF Yoshi Tsutsugo. |
| Aug 5, 2022 | Trade | Joel Peguero | Tampa Bay Rays | Colorado Rockies | Tampa Bay Rays traded RHP Joel Peguero to Colorado Rockies. |
| Aug 5, 2022 | Signed as free agent | D.J. Snelten | — | New York Yankees | New York Yankees signed free agent LHP D.J. Snelten to a minor league contract. |
| Aug 5, 2022 | Signed as free agent | Drake Batcho | — | Seattle Mariners | Seattle Mariners signed free agent LHP Drake Batcho to a minor league contract. |
| Aug 5, 2022 | Signed as free agent | Unnamed | — | Milwaukee Brewers | Milwaukee Brewers signed free agent C Estefano Lozano to a minor league contract. |
| Aug 5, 2022 | Signed as free agent | Justin Militello | — | Atlanta Braves | Atlanta Braves signed free agent RHP Justin Militello to a minor league contract. |
| Aug 5, 2022 | Signed as free agent | Erick Nava | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Erick Nava to a minor league contract. |
| Aug 4, 2022 | Signed as free agent | Daniel Johnson | — | Washington Nationals | Washington Nationals signed free agent RF Daniel Johnson to a minor league contract. |
| Aug 4, 2022 | Signed | Seth Stephenson | — | Detroit Tigers | Detroit Tigers signed OF Seth Stephenson. |
| Aug 4, 2022 | Signed | Troy Melton | — | Detroit Tigers | Detroit Tigers signed RHP Troy Melton. |
| Aug 4, 2022 | Signed | Trevin Michael | — | Detroit Tigers | Detroit Tigers signed RHP Trevin Michael. |
| Aug 4, 2022 | Signed | Will Brian | — | New York Yankees | New York Yankees signed LHP Will Brian. |
| Aug 4, 2022 | Signed | Shane Gray | — | New York Yankees | New York Yankees signed RHP Shane Gray. |
| Aug 4, 2022 | Signed | Tayler Aguilar | — | New York Yankees | New York Yankees signed OF Tayler Aguilar. |
| Aug 4, 2022 | Released | Didi Gregorius | — | Philadelphia Phillies | Philadelphia Phillies released SS Didi Gregorius. |
| Aug 4, 2022 | Released | Jackie Bradley Jr. | — | Boston Red Sox | Boston Red Sox released CF Jackie Bradley Jr.. |
| Aug 4, 2022 | Signed as free agent | J.T. Hintzen | — | Detroit Tigers | Detroit Tigers signed free agent RHP J.T. Hintzen to a minor league contract. |
| Aug 4, 2022 | Released | Tommy Milone | — | Seattle Mariners | Seattle Mariners released LHP Tommy Milone. |
| Aug 4, 2022 | Signed as free agent | Drew Jackson | — | San Francisco Giants | San Francisco Giants signed free agent SS Drew Jackson to a minor league contract. |
| Aug 4, 2022 | Signed as free agent | Connor Sadzeck | — | Washington Nationals | Washington Nationals signed free agent RHP Connor Sadzeck to a minor league contract. |
| Aug 4, 2022 | Signed as free agent | Mathieu Voros | — | New York Mets | New York Mets signed free agent RHP Mathieu Voros to a minor league contract. |
| Aug 4, 2022 | Signed as free agent | Kevin Miranda | — | Toronto Blue Jays | Toronto Blue Jays signed free agent RHP Kevin Miranda to a minor league contract. |
| Aug 3, 2022 | Released | Luke Barker | — | Milwaukee Brewers | Milwaukee Brewers released RHP Luke Barker. |
| Aug 3, 2022 | Signed | Cole Stupp | — | Detroit Tigers | Detroit Tigers signed RHP Cole Stupp. |
| Aug 3, 2022 | Released | Alcides Escobar | — | Washington Nationals | Washington Nationals released SS Alcides Escobar. |
| Aug 3, 2022 | Trade | Drew Maggi | Philadelphia Phillies | Pittsburgh Pirates | Philadelphia Phillies traded SS Drew Maggi to Pittsburgh Pirates for cash. |
| Aug 3, 2022 | Signed as free agent | Jancel Villarroel | — | Houston Astros | Houston Astros signed free agent C Jancel Villarroel to a minor league contract. |
| Aug 3, 2022 | Signed as free agent | Jordan Geber | — | New York Mets | New York Mets signed free agent RHP Jordan Geber to a minor league contract. |
| Aug 3, 2022 | Signed as free agent | Alexander Marte | — | Tampa Bay Rays | Tampa Bay Rays signed free agent Alexander Marte to a minor league contract. |
| Aug 3, 2022 | Signed as free agent | Yatner Crisostomo | — | Cleveland Guardians | Cleveland Guardians signed free agent RHP Yatner Crisostomo to a minor league contract. |
| Aug 3, 2022 | Signed as free agent | Javier Bartolozzi | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Javier Bartolozzi to a minor league contract. |
| Aug 2, 2022 | Trade | Robbie Grossman | Detroit Tigers | Atlanta Braves | Detroit Tigers traded LF Robbie Grossman to Atlanta Braves for LHP Kris Anglin. |
| Aug 2, 2022 | Trade | Mark Mathias | Milwaukee Brewers | Texas Rangers | Texas Rangers traded RHP Matt Bush to Milwaukee Brewers for 2B Mark Mathias and LHP Antoine Kelly. |
| Aug 2, 2022 | Trade | Ford Proctor | Tampa Bay Rays | San Francisco Giants | Tampa Bay Rays traded SS Ford Proctor to San Francisco Giants for RHP Jeremy Walker. |
| Aug 2, 2022 | Trade | Jake Odorizzi | Houston Astros | Atlanta Braves | Atlanta Braves traded LHP Will Smith to Houston Astros for RHP Jake Odorizzi. |
| Aug 2, 2022 | Signed | Carter Young | — | Baltimore Orioles | Baltimore Orioles signed SS Carter Young. |
| Aug 2, 2022 | Trade | Cade Povich | Minnesota Twins | Baltimore Orioles | Baltimore Orioles traded RHP Jorge Lopez and cash to Minnesota Twins for RHP Yennier Cano, LHP Cade Povich, LHP Juan Rojas and RHP Juan Nunez. |
| Aug 2, 2022 | Trade | Unnamed | Miami Marlins | Toronto Blue Jays | Toronto Blue Jays traded SS Jordan Groshans to Miami Marlins for RHP Zach Pop, RHP Anthony Bass and Player To Be Named Later. |
| Aug 2, 2022 | Trade | Josh Bell | Washington Nationals | San Diego Padres | Washington Nationals traded LF Juan Soto and 1B Josh Bell to San Diego Padres for 1B Luke Voit, LHP MacKenzie Gore, SS C.J. Abrams, OF Robert Hassell III, OF James Wood and RHP Jarlin Susana. |
| Aug 2, 2022 | Trade | Joey Gallo | New York Yankees | Los Angeles Dodgers | New York Yankees traded LF Joey Gallo to Los Angeles Dodgers for RHP Clayton Beeter. |
| Aug 2, 2022 | Trade | Spencer Steer | Minnesota Twins | Cincinnati Reds | Cincinnati Reds traded RHP Tyler Mahle to Minnesota Twins for SS Spencer Steer, 3B Christian Encarnacion-Strand and LHP Steve Hajjar. |
| Aug 2, 2022 | Trade | Logan O'Hoppe | Philadelphia Phillies | Los Angeles Angels | Los Angeles Angels traded OF Brandon Marsh to Philadelphia Phillies for C Logan O'Hoppe. |
| Aug 2, 2022 | Trade | Ben Brown | Philadelphia Phillies | Chicago Cubs | Chicago Cubs traded RHP David Robertson to Philadelphia Phillies for RHP Ben Brown. |
| Aug 2, 2022 | Trade | Ian Hamilton | Minnesota Twins | Cleveland Guardians | Cleveland Guardians traded C Sandy Leon to Minnesota Twins for RHP Ian Hamilton. |
| Aug 2, 2022 | Trade | Victor Acosta | San Diego Padres | Cincinnati Reds | Cincinnati Reds traded 2B Brandon Drury to San Diego Padres for SS Victor Acosta. |
| Aug 2, 2022 | Trade | J.D. Davis | New York Mets | San Francisco Giants | San Francisco Giants traded 1B Darin Ruf to New York Mets for 3B J.D. Davis, LHP Thomas Szapucki, RHP Carson Seymour and LHP Nick Zwack. |
| Aug 2, 2022 | Trade | Unnamed | Baltimore Orioles | Tampa Bay Rays | Tampa Bay Rays traded CF Brett Phillips to Baltimore Orioles for cash. |
| Aug 2, 2022 | Trade | Eric Hosmer | San Diego Padres | Boston Red Sox | San Diego Padres traded 1B Eric Hosmer, 2B Max Ferguson, OF Corey Rosier and cash to Boston Red Sox for LHP Jay Groome. |
| Aug 2, 2022 | Trade | Unnamed | Seattle Mariners | Los Angeles Dodgers | Los Angeles Dodgers traded 3B Jake Lamb to Seattle Mariners for Player To Be Named Later. |
| Aug 2, 2022 | Trade | Michael Fulmer | Detroit Tigers | Minnesota Twins | Detroit Tigers traded RHP Michael Fulmer to Minnesota Twins for RHP Sawyer Gipson-Long. |
| Aug 2, 2022 | Trade | Moises Brito | Toronto Blue Jays | Los Angeles Dodgers | Los Angeles Dodgers traded RHP Mitch White and 2B Alex De Jesus to Toronto Blue Jays for RHP Nick Frasso and LHP Moises Brito. |
| Aug 2, 2022 | Trade | Tristan Peters | Milwaukee Brewers | San Francisco Giants | San Francisco Giants traded RHP Trevor Rosenthal to Milwaukee Brewers for OF Tristan Peters. |
| Aug 2, 2022 | Trade | Matthew Boyd | San Francisco Giants | Seattle Mariners | San Francisco Giants traded LHP Matthew Boyd and C Curt Casali to Seattle Mariners for RHP Michael Stryffeler and C Andy Thomas. |
| Aug 2, 2022 | Trade | Jordan Montgomery | New York Yankees | St. Louis Cardinals | New York Yankees traded LHP Jordan Montgomery to St. Louis Cardinals for CF Harrison Bader. |
| Aug 2, 2022 | Trade | Austin Romine | St. Louis Cardinals | Cincinnati Reds | St. Louis Cardinals traded C Austin Romine to Cincinnati Reds for cash. |
| Aug 2, 2022 | Trade | Jeremy Beasley | Toronto Blue Jays | Pittsburgh Pirates | Toronto Blue Jays traded RHP Jeremy Beasley to Pittsburgh Pirates for cash. |
| Aug 2, 2022 | Trade | Saul Gonzalez | New York Mets | Chicago Cubs | Chicago Cubs traded RHP Mychal Givens to New York Mets for RHP Saul Gonzalez. |
| Aug 2, 2022 | Trade | Whit Merrifield | Kansas City Royals | Toronto Blue Jays | Kansas City Royals traded 2B Whit Merrifield to Toronto Blue Jays for RHP Max Castillo and 2B Samad Taylor. |
| Aug 2, 2022 | Trade | Jadiel Sanchez | Philadelphia Phillies | Los Angeles Angels | Los Angeles Angels traded RHP Noah Syndergaard to Philadelphia Phillies for CF Mickey Moniak and RF Jadiel Sanchez. |
| Aug 2, 2022 | Trade | Cam Gallagher | Kansas City Royals | San Diego Padres | San Diego Padres traded OF Brent Rooker to Kansas City Royals for C Cam Gallagher. |
| Aug 2, 2022 | Trade | Tucker Davidson | Atlanta Braves | Los Angeles Angels | Los Angeles Angels traded RHP Raisel Iglesias to Atlanta Braves for RHP Jesse Chavez and LHP Tucker Davidson. |
| Aug 2, 2022 | Trade | Carlos Guarate | St. Louis Cardinals | Athletics | Oakland Athletics traded C Austin Allen to St. Louis Cardinals for RHP Carlos Guarate. |
| Aug 2, 2022 | Signed | Ben Joyce | — | Los Angeles Angels | Los Angeles Angels signed RHP Ben Joyce. |
| Aug 2, 2022 | Signed | Jake Madden | — | Los Angeles Angels | Los Angeles Angels signed RHP Jake Madden. |
| Aug 2, 2022 | Signed | Victor Mederos | — | Los Angeles Angels | Los Angeles Angels signed RHP Victor Mederos. |
| Aug 2, 2022 | Signed | Roman Phansalkar | — | Los Angeles Angels | Los Angeles Angels signed RHP Roman Phansalkar. |
| Aug 2, 2022 | Signed | Matt Coutney | — | Los Angeles Angels | Los Angeles Angels signed 1B Matt Coutney. |
| Aug 2, 2022 | Signed | Caden Dana | — | Los Angeles Angels | Los Angeles Angels signed RHP Caden Dana. |
| Aug 2, 2022 | Signed | Jared Southard | — | Los Angeles Angels | Los Angeles Angels signed RHP Jared Southard. |
| Aug 2, 2022 | Signed | Sabin Ceballos | — | Los Angeles Angels | Los Angeles Angels signed C Sabin Ceballos. |
| Aug 2, 2022 | Signed | Bryce Osmond | — | Los Angeles Angels | Los Angeles Angels signed RHP Bryce Osmond. |
| Aug 2, 2022 | Signed | Samy Natera Jr. | — | Los Angeles Angels | Los Angeles Angels signed LHP Sammy Natera Jr.. |
| Aug 2, 2022 | Signed | Max Gieg | — | Los Angeles Angels | Los Angeles Angels signed RHP Max Gieg. |
| Aug 2, 2022 | Signed as free agent | Felipe Bello | — | Seattle Mariners | Seattle Mariners signed free agent RHP Felipe Bello to a minor league contract. |
| Aug 2, 2022 | Signed as free agent | Felipe Bello | — | Toronto Blue Jays | Toronto Blue Jays signed free agent RHP Felipe Bello to a minor league contract. |
| Aug 2, 2022 | Signed as free agent | Ramon Suarez | — | Toronto Blue Jays | Toronto Blue Jays signed free agent LHP Ramon Suarez to a minor league contract. |
| Aug 2, 2022 | Signed as free agent | Grant Kipp | — | Chicago Cubs | Chicago Cubs signed free agent RHP Grant Kipp to a minor league contract. |
| Aug 2, 2022 | Signed as free agent | Trey Nordmann | — | Baltimore Orioles | Baltimore Orioles signed free agent RHP Trey Nordmann to a minor league contract. |
| Aug 2, 2022 | Signed as free agent | Hayden Nierman | — | Baltimore Orioles | Baltimore Orioles signed free agent RHP Hayden Nierman to a minor league contract. |
| Aug 2, 2022 | Signed as free agent | Cooper Chandler | — | Baltimore Orioles | Baltimore Orioles signed free agent RHP Cooper Chandler to a minor league contract. |
| Aug 1, 2022 | Trade | Ehire Adrianza | Washington Nationals | Atlanta Braves | Washington Nationals traded SS Ehire Adrianza to Atlanta Braves for 2B Trey Harris. |
| Aug 1, 2022 | Signed | Dylan Lesko | — | San Diego Padres | San Diego Padres signed RHP Dylan Lesko. |
| Aug 1, 2022 | Signed | Robby Snelling | — | San Diego Padres | San Diego Padres signed LHP Robby Snelling. |
| Aug 1, 2022 | Signed | Adam Mazur | — | San Diego Padres | San Diego Padres signed RHP Adam Mazur. |
| Aug 1, 2022 | Signed | Henry Williams | — | San Diego Padres | San Diego Padres signed RHP Henry Williams. |
| Aug 1, 2022 | Signed | Lamar King Jr. | — | San Diego Padres | San Diego Padres signed C Lamar King Jr.. |
| Aug 1, 2022 | Signed | Nathan Martorella | — | San Diego Padres | San Diego Padres signed 1B Nathan Martorella. |
| Aug 1, 2022 | Signed | Nick Vogt | — | San Diego Padres | San Diego Padres signed OF Nick Vogt. |
| Aug 1, 2022 | Signed | Griffin Doersching | — | San Diego Padres | San Diego Padres signed 1B Griffin Doersching. |
| Aug 1, 2022 | Signed | Dylan Nedved | — | San Diego Padres | San Diego Padres signed RHP Dylan Nedved. |
| Aug 1, 2022 | Signed | Jackson Smeltz | — | San Diego Padres | San Diego Padres signed LHP Jackson Smeltz. |
| Aug 1, 2022 | Signed | Isaiah Lowe | — | San Diego Padres | San Diego Padres signed RHP Isaiah Lowe. |
| Aug 1, 2022 | Signed | Austin Krob | — | San Diego Padres | San Diego Padres signed LHP Austin Krob. |
| Aug 1, 2022 | Signed | Tyler Robertson | — | San Diego Padres | San Diego Padres signed OF Tyler Robertson. |
| Aug 1, 2022 | Signed | Thomas Balboni Jr. | — | San Diego Padres | San Diego Padres signed RHP Thomas Balboni Jr.. |
| Aug 1, 2022 | Signed | Henry Martinez | — | San Diego Padres | San Diego Padres signed RHP Henry Martinez. |
| Aug 1, 2022 | Signed | Spence Coffman | — | San Diego Padres | San Diego Padres signed SS Spence Coffman. |
| Aug 1, 2022 | Signed | Andrew Vail | — | San Diego Padres | San Diego Padres signed LHP Andrew Vail. |
| Aug 1, 2022 | Signed as free agent | David Morgan | — | San Diego Padres | San Diego Padres signed free agent RHP David Morgan to a minor league contract. |
| Aug 1, 2022 | Signed as free agent | Ian Koenig | — | San Diego Padres | San Diego Padres signed free agent RHP Ian Koenig to a minor league contract. |
| Aug 1, 2022 | Signed as free agent | Chase Valentine | — | San Diego Padres | San Diego Padres signed free agent SS Chase Valentine to a minor league contract. |
| Aug 1, 2022 | Signed as free agent | Will Geerdes | — | San Diego Padres | San Diego Padres signed free agent RHP Will Geerdes to a minor league contract. |
| Aug 1, 2022 | Signed as free agent | Matt Boswell | — | San Diego Padres | San Diego Padres signed free agent RHP Matt Boswell to a minor league contract. |
| Aug 1, 2022 | Signed as free agent | Cole Paplham | — | San Diego Padres | San Diego Padres signed free agent RHP Cole Paplham to a minor league contract. |
| Aug 1, 2022 | Signed as free agent | Devin Ortiz | — | San Diego Padres | San Diego Padres signed free agent RHP Devin Ortiz to a minor league contract. |
| Aug 1, 2022 | Signed as free agent | Jared Kollar | — | San Diego Padres | San Diego Padres signed free agent RHP Jared Kollar to a minor league contract. |
| Aug 1, 2022 | Signed as free agent | Kaden Hollow | — | San Diego Padres | San Diego Padres signed free agent C Kaden Hollow to a minor league contract. |
| Aug 1, 2022 | Signed as free agent | Braden Nett | — | San Diego Padres | San Diego Padres signed free agent RHP Braden Nett to a minor league contract. |
| Aug 1, 2022 | Trade | Hayden Wesneski | New York Yankees | Chicago Cubs | Chicago Cubs traded RHP Scott Effross to New York Yankees for RHP Hayden Wesneski. |
| Aug 1, 2022 | Trade | German Tapia | Tampa Bay Rays | Los Angeles Dodgers | Los Angeles Dodgers traded LHP Garrett Cleavinger to Tampa Bay Rays for OF German Tapia. |
| Aug 1, 2022 | Trade | Anthony Misiewicz | Seattle Mariners | Kansas City Royals | Seattle Mariners traded LHP Anthony Misiewicz to Kansas City Royals for cash. |
| Aug 1, 2022 | Trade | Josh Hader | Milwaukee Brewers | San Diego Padres | Milwaukee Brewers traded LHP Josh Hader to San Diego Padres for LHP Taylor Rogers, RHP Dinelson Lamet, 2B Esteury Ruiz and LHP Robert Gasser. |
| Aug 1, 2022 | Signed | Julian Bosnic | — | Pittsburgh Pirates | Pittsburgh Pirates signed LHP Julian Bosnic. |
| Aug 1, 2022 | Trade | Cooper Bowman | New York Yankees | Athletics | Oakland Athletics traded RHP Frankie Montas and RHP Lou Trivino to New York Yankees for LHP Ken Waldichuk, LHP JP Sears, RHP Luis Medina and 2B Cooper Bowman. |
| Aug 1, 2022 | Signed | Dalton Rushing | — | Los Angeles Dodgers | Los Angeles Dodgers signed C Dalton Rushing. |
| Aug 1, 2022 | Signed | Alex Freeland | — | Los Angeles Dodgers | Los Angeles Dodgers signed SS Alex Freeland. |
| Aug 1, 2022 | Signed | Nick Biddison | — | Los Angeles Dodgers | Los Angeles Dodgers signed OF Nick Biddison. |
| Aug 1, 2022 | Signed | Sean McLain | — | Los Angeles Dodgers | Los Angeles Dodgers signed SS Sean McLain. |
| Aug 1, 2022 | Signed | Logan Wagner | — | Los Angeles Dodgers | Los Angeles Dodgers signed SS Logan Wagner. |
| Aug 1, 2022 | Signed | Chris Campos | — | Los Angeles Dodgers | Los Angeles Dodgers signed RHP Chris Campos. |
| Aug 1, 2022 | Signed | Taylor Young | — | Los Angeles Dodgers | Los Angeles Dodgers signed 2B Taylor Young. |
| Aug 1, 2022 | Signed | Simon Reid | — | Los Angeles Dodgers | Los Angeles Dodgers signed C Simon Reid. |
| Aug 1, 2022 | Signed | Brandon Neeck | — | Los Angeles Dodgers | Los Angeles Dodgers signed LHP Brandon Neeck. |
| Aug 1, 2022 | Signed | Kyle Nevin | — | Los Angeles Dodgers | Los Angeles Dodgers signed OF Kyle Nevin. |
| Aug 1, 2022 | Signed | Jacob Meador | — | Los Angeles Dodgers | Los Angeles Dodgers signed RHP Jacob Meador. |
| Aug 1, 2022 | Signed | Chris Newell | — | Los Angeles Dodgers | Los Angeles Dodgers signed OF Chris Newell. |
| Aug 1, 2022 | Signed | Jose Izarra | — | Los Angeles Dodgers | Los Angeles Dodgers signed SS Jose Izarra. |
| Aug 1, 2022 | Signed | Nico Perez | — | Los Angeles Dodgers | Los Angeles Dodgers signed SS Nicolas Perez. |
| Aug 1, 2022 | Signed | Jared Karros | — | Los Angeles Dodgers | Los Angeles Dodgers signed RHP Jared Karros. |
| Aug 1, 2022 | Signed | Payton Martin | — | Los Angeles Dodgers | Los Angeles Dodgers signed RHP Payton Martin. |
| Aug 1, 2022 | Signed | Cameron Decker | — | Los Angeles Dodgers | Los Angeles Dodgers signed SS Cameron Decker. |
| Aug 1, 2022 | Signed | Bubba Alleyne | — | Los Angeles Dodgers | Los Angeles Dodgers signed OF Chris Alleyne. |
| Aug 1, 2022 | Signed as free agent | Connor Godwin | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Connor Godwin to a minor league contract. |
| Aug 1, 2022 | Signed as free agent | Carter Lohman | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent LHP Carter Lohman to a minor league contract. |
| Aug 1, 2022 | Signed as free agent | Livan Reinoso | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Livan Reinoso to a minor league contract. |
| Aug 1, 2022 | Signed as free agent | Lucas Wepf | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Lucas Wepf to a minor league contract. |
| Aug 1, 2022 | Signed | Christian Ruebeck | — | Los Angeles Dodgers | Los Angeles Dodgers signed RHP Christian Ruebeck. |
| Aug 1, 2022 | Signed as free agent | Liam Doolan | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Liam Doolan to a minor league contract. |
| Aug 1, 2022 | Trade | Trey Mancini | Baltimore Orioles | Houston Astros | Baltimore Orioles traded LF Trey Mancini to Houston Astros. |
| Aug 1, 2022 | Trade | Jayden Murray | Tampa Bay Rays | Houston Astros | Tampa Bay Rays traded RHP Jayden Murray to Houston Astros. |
| Aug 1, 2022 | Trade | Jose Siri | Houston Astros | Tampa Bay Rays | Houston Astros traded CF Jose Siri to Tampa Bay Rays. |
| Aug 1, 2022 | Trade | Chayce McDermott | Houston Astros | Baltimore Orioles | Houston Astros traded RHP Chayce McDermott to Baltimore Orioles. |
| Aug 1, 2022 | Trade | Seth Johnson | Tampa Bay Rays | Baltimore Orioles | Tampa Bay Rays traded RHP Seth Johnson to Baltimore Orioles. |
| Aug 1, 2022 | Signed as free agent | Jonathan Villar | — | Seattle Mariners | Seattle Mariners signed free agent SS Jonathan Villar to a minor league contract. |
| Aug 1, 2022 | Signed | D'Andre Smith | — | New York Mets | New York Mets signed SS D'Andre Smith. |
| Aug 1, 2022 | Signed | Tyler Stuart | — | New York Mets | New York Mets signed RHP Tyler Stuart. |
| Aug 1, 2022 | Signed | Jonah Tong | — | New York Mets | New York Mets signed RHP Jonah Tong. |
| Aug 1, 2022 | Signed | Dylan Tebrake | — | New York Mets | New York Mets signed RHP Dylan Tebrake. |
| Aug 1, 2022 | Signed | Chase Estep | — | New York Mets | New York Mets signed 3B Chase Estep. |
| Aug 1, 2022 | Signed | Zebulon Vermillion | — | New York Mets | New York Mets signed RHP Zebulon Vermillion. |
| Aug 1, 2022 | Signed | Rhylan Thomas | — | New York Mets | New York Mets signed OF Rhylan Thomas. |
| Aug 1, 2022 | Signed | Paul Gervase | — | New York Mets | New York Mets signed RHP Paul Gervase. |
| Aug 1, 2022 | Signed | Dylan Ross | — | New York Mets | New York Mets signed RHP Dylan Ross. |
| Aug 1, 2022 | Signed | Cameron Foster | — | New York Mets | New York Mets signed RHP Cameron Foster. |
| Aug 1, 2022 | Signed | Jimmy Loper | — | New York Mets | New York Mets signed RHP Jimmy Loper. |
| Aug 1, 2022 | Signed | Connor Brandon | — | New York Mets | New York Mets signed RHP Connor Brandon. |
| Aug 1, 2022 | Signed | Chris Santiago | — | New York Mets | New York Mets signed RHP Chris Santiago. |
| Aug 1, 2022 | Signed | Eli Ankeney | — | New York Mets | New York Mets signed LHP Eli Ankeney. |
| Aug 1, 2022 | Signed | Zach Morgan | — | San Francisco Giants | San Francisco Giants signed C Zach Morgan. |
| Aug 1, 2022 | Signed | Tyler Stone | — | Arizona Diamondbacks | Arizona Diamondbacks signed RHP Tyler Stone. |
| Aug 1, 2022 | Signed | Landon Green | — | Arizona Diamondbacks | Arizona Diamondbacks signed RHP Landon Green. |
| Aug 1, 2022 | Trade | Emmanuel Rivera | Kansas City Royals | Arizona Diamondbacks | Arizona Diamondbacks traded RHP Luke Weaver to Kansas City Royals for 3B Emmanuel Rivera. |
| Aug 1, 2022 | Trade | Reese McGuire | Chicago White Sox | Boston Red Sox | Boston Red Sox traded LHP Jake Diekman to Chicago White Sox for C Reese McGuire. |
| Aug 1, 2022 | Signed | Alex McFarlane | — | Philadelphia Phillies | Philadelphia Phillies signed RHP Alex McFarlane. |
| Aug 1, 2022 | Signed | Emaarion Boyd | — | Philadelphia Phillies | Philadelphia Phillies signed OF Emaarion Boyd. |
| Aug 1, 2022 | Signed | Nathan Karaffa | — | Philadelphia Phillies | Philadelphia Phillies signed RHP Nathan Karaffa. |
| Aug 1, 2022 | Trade | Enmanuel Valdez | Houston Astros | Boston Red Sox | Boston Red Sox traded C Christian Vazquez to Houston Astros for 2B Enmanuel Valdez and OF Wilyer Abreu. |
| Aug 1, 2022 | Trade | Tommy Pham | Cincinnati Reds | Boston Red Sox | Cincinnati Reds traded CF Tommy Pham to Boston Red Sox for Player To Be Named Later. |
| Aug 1, 2022 | Trade | Chris Stratton | Pittsburgh Pirates | St. Louis Cardinals | Pittsburgh Pirates traded LHP Jose Quintana and RHP Chris Stratton to St. Louis Cardinals for RHP Johan Oviedo and 3B Malcom Nunez. |
| Aug 1, 2022 | Signed | Jack Brannigan | — | Pittsburgh Pirates | Pittsburgh Pirates signed TWP Jack Brannigan. |
| Aug 1, 2022 | Signed | Brett Roberts | — | Miami Marlins | Miami Marlins signed SS Brett Roberts. |
| Aug 1, 2022 | Signed | Cade Gibson | — | Miami Marlins | Miami Marlins signed LHP Cade Gibson. |
| Aug 1, 2022 | Signed | Tayden Hall | — | Milwaukee Brewers | Milwaukee Brewers signed C Tayden Hall. |
| Aug 1, 2022 | Signed | Matthew Wood | — | Milwaukee Brewers | Milwaukee Brewers signed C Matthew Wood. |
| Aug 1, 2022 | Signed | Ben Metzinger | — | Milwaukee Brewers | Milwaukee Brewers signed 3B Ben Metzinger. |
| Aug 1, 2022 | Signed | Robert Moore | — | Milwaukee Brewers | Milwaukee Brewers signed SS Robert Moore. |
| Aug 1, 2022 | Signed as free agent | Reece Walling | — | Milwaukee Brewers | Milwaukee Brewers signed free agent 1B Reece Walling to a minor league contract. |
| Aug 1, 2022 | Signed as free agent | Jack Dallas | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RHP Jack Dallas to a minor league contract. |
| Aug 1, 2022 | Signed | Eric Brown Jr. | — | Milwaukee Brewers | Milwaukee Brewers signed SS Eric Brown Jr.. |
| Aug 1, 2022 | Signed | Satchell Norman | — | Milwaukee Brewers | Milwaukee Brewers signed C Satchell Norman. |
| Aug 1, 2022 | Signed as free agent | Braeden Fausnaught | — | Philadelphia Phillies | Philadelphia Phillies signed free agent LHP Braeden Fausnaught to a minor league contract. |
| Aug 1, 2022 | Signed as free agent | Eric Garcia | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RHP Eric Garcia to a minor league contract. |
| Aug 1, 2022 | Signed as free agent | Ryan Leitch | — | Philadelphia Phillies | Philadelphia Phillies signed free agent C Ryan Leitch to a minor league contract. |
| Aug 1, 2022 | Signed as free agent | Otto Kemp | — | Philadelphia Phillies | Philadelphia Phillies signed free agent 3B Otto Kemp to a minor league contract. |
| Aug 1, 2022 | Signed as free agent | Ty Penner | — | Philadelphia Phillies | Philadelphia Phillies signed free agent 1B Ty Penner to a minor league contract. |
| Aug 1, 2022 | Signed as free agent | Andrew Walling | — | Philadelphia Phillies | Philadelphia Phillies signed free agent LHP Andrew Walling to a minor league contract. |
| Aug 1, 2022 | Signed as free agent | Jake Meyer | — | Colorado Rockies | Colorado Rockies signed free agent C Jake Meyer to a minor league contract. |
| Aug 1, 2022 | Signed as free agent | Tyler Johnson | — | Detroit Tigers | Detroit Tigers signed free agent OF Tyler Johnson to a minor league contract. |
| Aug 1, 2022 | Signed as free agent | Daniel Keaney | — | Texas Rangers | Texas Rangers signed free agent RHP Daniel Keaney to a minor league contract. |
| Aug 1, 2022 | Signed as free agent | Kolton Curtis | — | Texas Rangers | Texas Rangers signed free agent RHP Kolton Curtis to a minor league contract. |
| Aug 1, 2022 | Signed as free agent | Hudson Livesey | — | Miami Marlins | Miami Marlins signed free agent C Hudson Livesey to a minor league contract. |
| Aug 1, 2022 | Signed as free agent | Colin Burgess | — | Detroit Tigers | Detroit Tigers signed free agent C Colin Burgess to a minor league contract. |
| Aug 1, 2022 | Signed | Geo Rivera Jr. | — | Cleveland Guardians | Cleveland Guardians signed RHP Geo Rivera Jr.. |
| Aug 1, 2022 | Signed as free agent | Jake Thompson | — | Miami Marlins | Miami Marlins signed free agent 3B Jake Thompson to a minor league contract. |
| Jul 31, 2022 | Signed | Mark McLaughlin | — | Chicago White Sox | Chicago White Sox signed RHP Mark McLaughlin. |
| Jul 31, 2022 | Signed | Mario Camilletti | — | Chicago White Sox | Chicago White Sox signed 2B Mario Camilletti. |
| Jul 31, 2022 | Signed | Michael Turner | — | Chicago White Sox | Chicago White Sox signed C Michael Turner. |
| Jul 31, 2022 | Signed | Tim Elko | — | Chicago White Sox | Chicago White Sox signed 1B Tim Elko. |
| Jul 31, 2022 | Signed | Brooks Baldwin | — | Chicago White Sox | Chicago White Sox signed 3B Brooks Baldwin. |
| Jul 31, 2022 | Signed | Mason Adams | — | Chicago White Sox | Chicago White Sox signed RHP Mason Adams. |
| Jul 31, 2022 | Signed | Tristan Stivors | — | Chicago White Sox | Chicago White Sox signed RHP Tristan Stivors. |
| Jul 31, 2022 | Signed | Nick Altermatt | — | Chicago White Sox | Chicago White Sox signed RHP Nick Altermatt. |
| Jul 31, 2022 | Signed | Drake Logan | — | Chicago White Sox | Chicago White Sox signed 3B Drake Logan. |
| Jul 31, 2022 | Signed as free agent | Connor McCullough | — | Chicago White Sox | Chicago White Sox signed free agent RHP Connor McCullough to a minor league contract. |
| Jul 31, 2022 | Signed as free agent | Drew McDaniel | — | Chicago White Sox | Chicago White Sox signed free agent RHP Drew McDaniel to a minor league contract. |
| Jul 31, 2022 | Signed as free agent | Eric Hildebrand | — | Chicago White Sox | Chicago White Sox signed free agent RHP Eric Hildebrand to a minor league contract. |
| Jul 31, 2022 | Signed as free agent | Jake Palisch | — | Chicago White Sox | Chicago White Sox signed free agent LHP Jake Palisch to a minor league contract. |
| Jul 31, 2022 | Signed as free agent | Kole Ramage | — | Chicago White Sox | Chicago White Sox signed free agent RHP Kole Ramage to a minor league contract. |
| Jul 31, 2022 | Signed as free agent | Troy Claunch | — | Chicago White Sox | Chicago White Sox signed free agent C Troy Claunch to a minor league contract. |
| Jul 31, 2022 | Signed as free agent | Taishi Nakawake | — | Chicago White Sox | Chicago White Sox signed free agent SS Taishi Nakawake to a minor league contract. |
| Jul 31, 2022 | Signed as free agent | Chris Lanzilli | — | Chicago White Sox | Chicago White Sox signed free agent OF Chris Lanzilli to a minor league contract. |
| Jul 31, 2022 | Signed | Demetrio Crisantes | — | Arizona Diamondbacks | Arizona Diamondbacks signed SS Demetrio Crisantes. |
| Jul 31, 2022 | Signed | Gavin Logan | — | Arizona Diamondbacks | Arizona Diamondbacks signed C Gavin Logan. |
| Jul 31, 2022 | Signed | Spencer Giesting | — | Arizona Diamondbacks | Arizona Diamondbacks signed LHP Spencer Giesting. |
| Jul 31, 2022 | Signed | Kevin Graham | — | Arizona Diamondbacks | Arizona Diamondbacks signed OF Kevin Graham. |
| Jul 31, 2022 | Signed | Joshua Day | — | Arizona Diamondbacks | Arizona Diamondbacks signed SS Joshua Day. |
| Jul 31, 2022 | Trade | Raynel Espinal | San Francisco Giants | Chicago Cubs | Chicago Cubs traded 2B Dixon Machado to San Francisco Giants for RHP Raynel Espinal. |
| Jul 31, 2022 | Signed as free agent | Cole Moore | — | Philadelphia Phillies | Philadelphia Phillies signed free agent C Cole Moore to a minor league contract. |
| Jul 31, 2022 | Signed as free agent | Joshuan Sandoval | — | Tampa Bay Rays | Tampa Bay Rays signed free agent C Joshuan Sandoval to a minor league contract. |
| Jul 30, 2022 | Trade | Andrew Moore | Seattle Mariners | Cincinnati Reds | Cincinnati Reds traded RHP Luis Castillo to Seattle Mariners for SS Noelvi Marte, SS Edwin Arroyo, RHP Levi Stoudt and RHP Andrew Moore. |
| Jul 30, 2022 | Signed as free agent | Braedon Karpathios | — | San Diego Padres | San Diego Padres signed free agent OF Braedon Karpathios. |
| Jul 30, 2022 | Signed | Jakob Marsee | — | San Diego Padres | San Diego Padres signed OF Jakob Marsee. |
| Jul 30, 2022 | Signed as free agent | Kai Murphy | — | San Diego Padres | San Diego Padres signed free agent OF Kai Murphy to a minor league contract. |
| Jul 30, 2022 | Signed | Graham Pauley | — | San Diego Padres | San Diego Padres signed 3B Graham Pauley. |
| Jul 30, 2022 | Signed | Nazier Mulé | — | Chicago Cubs | Chicago Cubs signed RHP Nazier Mule. |
| Jul 30, 2022 | Signed | Branden Noriega | — | Chicago Cubs | Chicago Cubs signed LHP Branden Noriega. |
| Jul 30, 2022 | Signed | Mathew Peters | — | Chicago Cubs | Chicago Cubs signed RHP Mathew Peters. |
| Jul 30, 2022 | Signed | Luis Rujano | — | Chicago Cubs | Chicago Cubs signed RHP Luis Rujano. |
| Jul 30, 2022 | Signed | Shane Marshall | — | Chicago Cubs | Chicago Cubs signed RHP Shane Marshall. |
| Jul 30, 2022 | Signed | Haydn McGeary | — | Chicago Cubs | Chicago Cubs signed C Haydn McGeary. |
| Jul 30, 2022 | Signed | JP Wheat | — | Chicago Cubs | Chicago Cubs signed RHP JP Wheat. |
| Jul 30, 2022 | Signed | Andy Garriola | — | Chicago Cubs | Chicago Cubs signed OF Andy Garriola. |
| Jul 30, 2022 | Signed | Garrett Brown | — | Chicago Cubs | Chicago Cubs signed RHP Garrett Brown. |
| Jul 30, 2022 | Signed | Ke'Shun Collier | — | Chicago Cubs | Chicago Cubs signed OF Ke'Shun Collier. |
| Jul 30, 2022 | Trade | Edmundo Sosa | St. Louis Cardinals | Philadelphia Phillies | St. Louis Cardinals traded 2B Edmundo Sosa to Philadelphia Phillies for LHP JoJo Romero. |
| Jul 30, 2022 | Trade | Chris Martin | Chicago Cubs | Los Angeles Dodgers | Chicago Cubs traded RHP Chris Martin to Los Angeles Dodgers for 2B Zach McKinstry. |
| Jul 30, 2022 | Signed | Owen Murphy | — | Atlanta Braves | Atlanta Braves signed RHP Owen Murphy. |
| Jul 30, 2022 | Signed | JR Ritchie | — | Atlanta Braves | Atlanta Braves signed RHP JR Ritchie. |
| Jul 30, 2022 | Signed | Blake Burkhalter | — | Atlanta Braves | Atlanta Braves signed RHP Blake Burkhalter. |
| Jul 30, 2022 | Signed | Drake Baldwin | — | Atlanta Braves | Atlanta Braves signed C Drake Baldwin. |
| Jul 30, 2022 | Signed | David McCabe | — | Atlanta Braves | Atlanta Braves signed 3B David McCabe. |
| Jul 30, 2022 | Signed | Nacho Alvarez Jr. | — | Atlanta Braves | Atlanta Braves signed 3B Ignacio Alvarez. |
| Jul 30, 2022 | Signed | Seth Keller | — | Atlanta Braves | Atlanta Braves signed RHP Seth Keller. |
| Jul 30, 2022 | Signed | Adam Maier | — | Atlanta Braves | Atlanta Braves signed RHP Adam Maier. |
| Jul 30, 2022 | Signed | Jason Franks | — | Atlanta Braves | Atlanta Braves signed RHP Jason Franks. |
| Jul 30, 2022 | Signed | Cory Acton | — | Atlanta Braves | Atlanta Braves signed 2B Cory Acton. |
| Jul 30, 2022 | Signed | Andrew Keck | — | Atlanta Braves | Atlanta Braves signed C Andrew Keck. |
| Jul 30, 2022 | Signed | Ian Mejia | — | Atlanta Braves | Atlanta Braves signed RHP Ian Mejia. |
| Jul 30, 2022 | Signed | Justin Janas | — | Atlanta Braves | Atlanta Braves signed 1B Justin Janas. |
| Jul 30, 2022 | Signed | Cedric De Grandpre | — | Atlanta Braves | Atlanta Braves signed RHP Cedric De Grandpre. |
| Jul 30, 2022 | Signed | Landon Harper | — | Atlanta Braves | Atlanta Braves signed RHP Landon Harper. |
| Jul 30, 2022 | Signed | William Silva | — | Atlanta Braves | Atlanta Braves signed RHP William Silva. |
| Jul 30, 2022 | Signed | E.J. Exposito | — | Atlanta Braves | Atlanta Braves signed SS E.J. Exposito. |
| Jul 30, 2022 | Signed | Kevin Kilpatrick Jr. | — | Atlanta Braves | Atlanta Braves signed OF Kevin Kilpatrick Jr.. |
| Jul 30, 2022 | Signed | Noah Williams | — | Atlanta Braves | Atlanta Braves signed OF Noah Williams. |
| Jul 30, 2022 | Signed | Christian Jackson | — | Atlanta Braves | Atlanta Braves signed OF Christian Jackson. |
| Jul 30, 2022 | Signed | Keshawn Ogans | — | Atlanta Braves | Atlanta Braves signed SS Keshawn Ogans. |
| Jul 30, 2022 | Signed as free agent | Nick Clarno | — | Atlanta Braves | Atlanta Braves signed free agent C Nick Clarno to a minor league contract. |
| Jul 30, 2022 | Signed as free agent | Hayden Harris | — | Atlanta Braves | Atlanta Braves signed free agent LHP Hayden Harris to a minor league contract. |
| Jul 30, 2022 | Signed as free agent | Harry Owen | — | Atlanta Braves | Atlanta Braves signed free agent C Harrison Owen to a minor league contract. |
| Jul 30, 2022 | Signed as free agent | Hunter Riggins | — | Atlanta Braves | Atlanta Braves signed free agent RHP Hunter Riggins to a minor league contract. |
| Jul 30, 2022 | Signed as free agent | Bryson Worrell | — | Atlanta Braves | Atlanta Braves signed free agent OF Bryson Worrell to a minor league contract. |
| Jul 30, 2022 | Signed | Alex Iadisernia | — | St. Louis Cardinals | St. Louis Cardinals signed OF Alex Iadisernia. |
| Jul 30, 2022 | Signed | Chris Rotondo | — | St. Louis Cardinals | St. Louis Cardinals signed OF Chris Rotondo. |
| Jul 30, 2022 | Trade | David Peralta | Arizona Diamondbacks | Tampa Bay Rays | Arizona Diamondbacks traded LF David Peralta to Tampa Bay Rays for C Christian Cerda. |
| Jul 30, 2022 | Signed | Kevin Parada | — | New York Mets | New York Mets signed C Kevin Parada. |
| Jul 30, 2022 | Signed | Zack Showalter | — | Baltimore Orioles | Baltimore Orioles signed RHP Zack Showalter. |
| Jul 30, 2022 | Signed as free agent | Adonys Perez | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent LHP Adonys Perez to a minor league contract. |
| Jul 30, 2022 | Signed | Jamaliel Rosado Jr. | — | Athletics | Oakland Athletics signed SS Jamaliel Rosado Jr.. |
| Jul 30, 2022 | Signed as free agent | Jeffrey Wilson | — | New York Mets | New York Mets signed free agent RHP Jeffrey Wilson to a minor league contract. |
| Jul 30, 2022 | Signed | Chase DeLauter | — | Cleveland Guardians | Cleveland Guardians signed OF Chase DeLauter. |
| Jul 30, 2022 | Signed | Justin Campbell | — | Cleveland Guardians | Cleveland Guardians signed RHP Justin Campbell. |
| Jul 30, 2022 | Signed | Parker Messick | — | Cleveland Guardians | Cleveland Guardians signed LHP Parker Messick. |
| Jul 30, 2022 | Signed | Jacob Zibin | — | Cleveland Guardians | Cleveland Guardians signed RHP Jacob Zibin. |
| Jul 30, 2022 | Signed | Adam Tulloch | — | Cleveland Guardians | Cleveland Guardians signed LHP Adam Tulloch. |
| Jul 30, 2022 | Signed | Zach Jacobs | — | Cleveland Guardians | Cleveland Guardians signed RHP Zach Jacobs. |
| Jul 30, 2022 | Signed as free agent | Zack Qin | — | San Diego Padres | San Diego Padres signed free agent LHP Zimo Qin to a minor league contract. |
| Jul 30, 2022 | Signed | Jack Jasiak | — | Cleveland Guardians | Cleveland Guardians signed RHP Jack Jasiak. |
| Jul 30, 2022 | Signed | Javier Santos | — | Cleveland Guardians | Cleveland Guardians signed RHP Javier Santos. |
| Jul 30, 2022 | Signed | Guy Lipscomb | — | Cleveland Guardians | Cleveland Guardians signed OF Guy Lipscomb Jr.. |
| Jul 30, 2022 | Signed | Matt Wyatt | — | Tampa Bay Rays | Tampa Bay Rays signed RHP Matt Wyatt. |
| Jul 30, 2022 | Signed | Logun Clark | — | Cleveland Guardians | Cleveland Guardians signed C Logun Clark. |
| Jul 30, 2022 | Signed | Pres Cavenaugh | — | Cleveland Guardians | Cleveland Guardians signed OF Pres Cavenaugh. |
| Jul 30, 2022 | Signed | Dylan DeLucia | — | Cleveland Guardians | Cleveland Guardians signed RHP Dylan DeLucia. |
| Jul 30, 2022 | Signed | Jackson Humphries | — | Cleveland Guardians | Cleveland Guardians signed LHP Jackson Humphries. |
| Jul 30, 2022 | Signed | Tyresse Turner | — | Cleveland Guardians | Cleveland Guardians signed SS Tyresse Turner. |
| Jul 30, 2022 | Signed | Shawn Rapp | — | Cleveland Guardians | Cleveland Guardians signed LHP Shawn Rapp. |
| Jul 30, 2022 | Signed | Nate Furman | — | Cleveland Guardians | Cleveland Guardians signed 2B Nate Furman. |
| Jul 30, 2022 | Signed | Marc Filia | — | Cleveland Guardians | Cleveland Guardians signed C Marc Filia. |
| Jul 30, 2022 | Signed | Magnus Ellerts | — | Cleveland Guardians | Cleveland Guardians signed RHP Magnus Ellerts. |
| Jul 30, 2022 | Signed | Angel Zarate | — | Cleveland Guardians | Cleveland Guardians signed OF Angel Zarate. |
| Jul 30, 2022 | Signed | Austin Peterson | — | Cleveland Guardians | Cleveland Guardians signed RHP Austin Peterson. |
| Jul 30, 2022 | Signed as free agent | Gage Stanifer | — | Toronto Blue Jays | Toronto Blue Jays signed free agent RHP Gage Stanifer to a minor league contract. |
| Jul 30, 2022 | Signed | John Garcia | — | Houston Astros | Houston Astros signed C John Garcia. |
| Jul 29, 2022 | Signed as free agent | Brad Peacock | — | Minnesota Twins | Minnesota Twins signed free agent RHP Brad Peacock to a minor league contract. |
| Jul 29, 2022 | Signed as free agent | Beau Taylor | — | Athletics | Oakland Athletics signed free agent C Beau Taylor to a minor league contract. |
| Jul 29, 2022 | Signed | Dylan Ray | — | Arizona Diamondbacks | Arizona Diamondbacks signed RHP Dylan Ray. |
| Jul 29, 2022 | Signed | Will Mabrey | — | Arizona Diamondbacks | Arizona Diamondbacks signed LHP Will Mabrey. |
| Jul 29, 2022 | Signed | Eli Saul | — | Arizona Diamondbacks | Arizona Diamondbacks signed RHP Eli Saul. |
| Jul 29, 2022 | Signed as free agent | Ryan Weber | — | New York Yankees | New York Yankees signed free agent RHP Ryan Weber to a minor league contract. |
| Jul 29, 2022 | Signed as free agent | Shane Greene | — | New York Yankees | New York Yankees signed free agent RHP Shane Greene to a minor league contract. |
| Jul 29, 2022 | Signed | Termarr Johnson | — | Pittsburgh Pirates | Pittsburgh Pirates signed SS Termarr Johnson. |
| Jul 29, 2022 | Signed | Jimmy Crooks | — | St. Louis Cardinals | St. Louis Cardinals signed C Jimmy Crooks III. |
| Jul 29, 2022 | Signed | Michael Curialle | — | St. Louis Cardinals | St. Louis Cardinals signed SS Michael Curialle. |
| Jul 29, 2022 | Signed | Brody Moore | — | St. Louis Cardinals | St. Louis Cardinals signed SS Brody Moore. |
| Jul 29, 2022 | Signed | Victor Scott II | — | St. Louis Cardinals | St. Louis Cardinals signed OF Victor Scott II. |
| Jul 29, 2022 | Signed | José Peraza | — | Boston Red Sox | Boston Red Sox signed SS Jose Peraza. |
| Jul 29, 2022 | Signed as free agent | Taylor Motter | — | Atlanta Braves | Atlanta Braves signed free agent 2B Taylor Motter to a minor league contract. |
| Jul 29, 2022 | Signed | Roman Anthony | — | Boston Red Sox | Boston Red Sox signed OF Roman Anthony. |
| Jul 29, 2022 | Signed | Deundre Jones | — | Boston Red Sox | Boston Red Sox signed OF Deundre Jones. |
| Jul 29, 2022 | Signed | Chase Meidroth | — | Boston Red Sox | Boston Red Sox signed SS Chase Meidroth. |
| Jul 29, 2022 | Signed | Brooks Brannon | — | Boston Red Sox | Boston Red Sox signed C Brooks Brannon. |
| Jul 29, 2022 | Signed | Dalton Rogers | — | Boston Red Sox | Boston Red Sox signed LHP Dalton Rogers. |
| Jul 29, 2022 | Signed | Hayden Mullins | — | Boston Red Sox | Boston Red Sox signed LHP Hayden Mullins. |
| Jul 29, 2022 | Signed | Noah Dean | — | Boston Red Sox | Boston Red Sox signed LHP Noah Dean. |
| Jul 29, 2022 | Signed | Connor Butler | — | Boston Red Sox | Boston Red Sox signed LHP Connor Butler. |
| Jul 29, 2022 | Signed | Nathan Landry | — | Boston Red Sox | Boston Red Sox signed LHP Nathan Landry. |
| Jul 29, 2022 | Signed | Marques Johnson | — | Boston Red Sox | Boston Red Sox signed RHP Marques Johnson. |
| Jul 29, 2022 | Signed | Garrett Ramsey | — | Boston Red Sox | Boston Red Sox signed RHP Garrett Ramsey. |
| Jul 29, 2022 | Signed | Jaret Godman | — | Boston Red Sox | Boston Red Sox signed RHP Jaret Godman. |
| Jul 29, 2022 | Signed as free agent | Wilfry Pena | — | Washington Nationals | Washington Nationals signed free agent RHP Wilfry Pena to a minor league contract. |
| Jul 29, 2022 | Signed | Chase Luttrell | — | Miami Marlins | Miami Marlins signed OF Chase Luttrell. |
| Jul 29, 2022 | Signed as free agent | Collin Lowe | — | Miami Marlins | Miami Marlins signed free agent RHP Collin Lowe to a minor league contract. |
| Jul 29, 2022 | Signed | Colby Thomas | — | Athletics | Oakland Athletics signed OF Colby Thomas. |
| Jul 29, 2022 | Signed | Cayden Wallace | — | Kansas City Royals | Kansas City Royals signed 3B Cayden Wallace. |
| Jul 29, 2022 | Signed as free agent | Jack Masloff | — | Detroit Tigers | Detroit Tigers signed free agent LHP Jack Masloff to a minor league contract. |
| Jul 29, 2022 | Signed | Jacob Watters | — | Athletics | Oakland Athletics signed RHP Jacob Watters. |
| Jul 29, 2022 | Signed as free agent | Kelsey Ward | — | Toronto Blue Jays | Toronto Blue Jays signed free agent LHP Kelsey Ward to a minor league contract. |
| Jul 29, 2022 | Signed as free agent | Jerry Huntzinger | — | Toronto Blue Jays | Toronto Blue Jays signed free agent C Jerry Huntzinger to a minor league contract. |
| Jul 29, 2022 | Signed | Gabriel Hughes | — | Colorado Rockies | Colorado Rockies signed RHP Gabriel Hughes. |
| Jul 29, 2022 | Signed as free agent | Brian Gursky | — | New York Mets | New York Mets signed free agent LHP Brian Gursky to a minor league contract. |
| Jul 29, 2022 | Signed | Austin Charles | — | Kansas City Royals | Kansas City Royals signed TWP Austin Charles. |
| Jul 29, 2022 | Signed | Jackson Ferris | — | Chicago Cubs | Chicago Cubs signed LHP Jackson Ferris. |
| Jul 29, 2022 | Signed as free agent | Joel Heredia | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RHP Joel Heredia to a minor league contract. |
| Jul 29, 2022 | Signed | Jack Pineda | — | Kansas City Royals | Kansas City Royals signed SS Jack Pineda. |
| Jul 29, 2022 | Signed | Gary Gill Hill | — | Tampa Bay Rays | Tampa Bay Rays signed RHP Gary Gill Hill. |
| Jul 28, 2022 | Signed | Jacob Berry | — | Miami Marlins | Miami Marlins signed 3B Jacob Berry. |
| Jul 28, 2022 | Signed | Torin Montgomery | — | Miami Marlins | Miami Marlins signed 1B Torin Montgomery. |
| Jul 28, 2022 | Signed as free agent | Danny Santana | — | Boston Red Sox | Boston Red Sox signed free agent SS Danny Santana to a minor league contract. |
| Jul 28, 2022 | Signed | Josiah Sightler | — | Pittsburgh Pirates | Pittsburgh Pirates signed 1B Josiah Sightler. |
| Jul 28, 2022 | Signed | Andrew Taylor | — | Houston Astros | Houston Astros signed RHP Andrew Taylor. |
| Jul 28, 2022 | Signed | Ryan Clifford | — | Houston Astros | Houston Astros signed OF Ryan Clifford. |
| Jul 28, 2022 | Signed | Zach Dezenzo | — | Houston Astros | Houston Astros signed SS Zach Dezenzo. |
| Jul 28, 2022 | Signed | Tommy Sacco Jr. | — | Houston Astros | Houston Astros signed SS Tommy Sacco Jr.. |
| Jul 28, 2022 | Signed | Joey Mancini | — | Houston Astros | Houston Astros signed RHP Joey Mancini. |
| Jul 28, 2022 | Signed | Tim Borden II | — | Houston Astros | Houston Astros signed SS Tim Borden II. |
| Jul 28, 2022 | Signed | Austin Temple | — | Houston Astros | Houston Astros signed RHP Austin Temple. |
| Jul 28, 2022 | Signed | Logan VanWey | — | Houston Astros | Houston Astros signed RHP Logan VanWey. |
| Jul 28, 2022 | Signed | Ryan Wrobleski | — | Houston Astros | Houston Astros signed C Ryan Wrobleski. |
| Jul 28, 2022 | Signed | Garrett McGowan | — | Houston Astros | Houston Astros signed 1B Garrett McGowan. |
| Jul 28, 2022 | Signed | Chandler Pollard | — | Texas Rangers | Texas Rangers signed OF Chandler Pollard. |
| Jul 28, 2022 | Signed | Tommy Specht | — | Texas Rangers | Texas Rangers signed OF Tommy Specht. |
| Jul 28, 2022 | Signed | Andrew Owen | — | Texas Rangers | Texas Rangers signed RHP Andrew Owen. |
| Jul 28, 2022 | Signed | Luis Ramirez | — | Texas Rangers | Texas Rangers signed RHP Luis Ramirez. |
| Jul 28, 2022 | Signed | Reggie Crawford | — | San Francisco Giants | San Francisco Giants signed TWP Reggie Crawford. |
| Jul 28, 2022 | Signed | Carson Whisenhunt | — | San Francisco Giants | San Francisco Giants signed LHP Carson Whisenhunt. |
| Jul 28, 2022 | Signed | William Kempner | — | San Francisco Giants | San Francisco Giants signed RHP William Kempner. |
| Jul 28, 2022 | Signed | Spencer Miles | — | San Francisco Giants | San Francisco Giants signed RHP Spencer Miles. |
| Jul 28, 2022 | Signed | Liam Simon | — | San Francisco Giants | San Francisco Giants signed RHP Liam Simon. |
| Jul 28, 2022 | Signed | Hayden Birdsong | — | San Francisco Giants | San Francisco Giants signed RHP Hayden Birdsong. |
| Jul 28, 2022 | Signed | Zach Morgan | — | San Francisco Giants | San Francisco Giants signed C Zach Morgan. |
| Jul 28, 2022 | Signed | Wade Meckler | — | San Francisco Giants | San Francisco Giants signed OF Wade Meckler. |
| Jul 28, 2022 | Signed | Jack Choate | — | San Francisco Giants | San Francisco Giants signed LHP Jack Choate. |
| Jul 28, 2022 | Signed | John Michael Bertrand | — | San Francisco Giants | San Francisco Giants signed LHP John Bertrand. |
| Jul 28, 2022 | Signed | Sam Bower | — | San Francisco Giants | San Francisco Giants signed RHP Sam Bower. |
| Jul 28, 2022 | Signed | Tyler Vogel | — | San Francisco Giants | San Francisco Giants signed RHP Tyler Vogel. |
| Jul 28, 2022 | Signed | Thomas Gavello | — | San Francisco Giants | San Francisco Giants signed C Thomas Gavello. |
| Jul 28, 2022 | Signed | Nomar Diaz | — | San Francisco Giants | San Francisco Giants signed C Nomar Diaz. |
| Jul 28, 2022 | Signed | Tanner O'Tremba | — | San Francisco Giants | San Francisco Giants signed OF Tanner O'Tremba. |
| Jul 28, 2022 | Signed | Andrew Kachel | — | San Francisco Giants | San Francisco Giants signed 2B Andrew Kachel. |
| Jul 28, 2022 | Signed | Justin Bench | — | San Francisco Giants | San Francisco Giants signed SS Justin Bench. |
| Jul 28, 2022 | Signed as free agent | Carter Howell | — | San Francisco Giants | San Francisco Giants signed free agent OF Carter Howell to a minor league contract. |
| Jul 28, 2022 | Signed as free agent | Hayden Wynja | — | San Francisco Giants | San Francisco Giants signed free agent LHP Hayden Wynja to a minor league contract. |
| Jul 28, 2022 | Signed as free agent | Matt Higgins | — | San Francisco Giants | San Francisco Giants signed free agent OF Matt Higgins to a minor league contract. |
| Jul 28, 2022 | Signed as free agent | Davis Hare | — | San Francisco Giants | San Francisco Giants signed free agent RHP Davis Hare to a minor league contract. |
| Jul 28, 2022 | Signed | Romeo Sanabria | — | San Diego Padres | San Diego Padres signed C Romeo Sanabria. |
| Jul 28, 2022 | Trade | Phillip Diehl | Cincinnati Reds | New York Mets | Cincinnati Reds traded CF Tyler Naquin and LHP Phillip Diehl to New York Mets for 2B Hector Rodriguez and RHP Jose Acuna. |
| Jul 28, 2022 | Signed | Peyton Pallette | — | Chicago White Sox | Chicago White Sox signed RHP Peyton Pallette. |
| Jul 28, 2022 | Signed | Jonathan Cannon | — | Chicago White Sox | Chicago White Sox signed RHP Jonathan Cannon. |
| Jul 28, 2022 | Signed | Jordan Sprinkle | — | Chicago White Sox | Chicago White Sox signed SS Jordan Sprinkle. |
| Jul 28, 2022 | Signed | Eric Adler | — | Chicago White Sox | Chicago White Sox signed RHP Eric Adler. |
| Jul 28, 2022 | Signed | Cameron Wagoner | — | Milwaukee Brewers | Milwaukee Brewers signed RHP Cameron Wagoner. |
| Jul 28, 2022 | Signed as free agent | Tyler Wehrle | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Tyler Wehrle to a minor league contract. |
| Jul 28, 2022 | Signed as free agent | Juan Hernandez | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Juan Hernandez to a minor league contract. |
| Jul 28, 2022 | Signed as free agent | Ramses Velazquez | — | San Diego Padres | San Diego Padres signed free agent OF Ramses Velazquez to a minor league contract. |
| Jul 28, 2022 | Signed | Jared Poland | — | Miami Marlins | Miami Marlins signed RHP Jared Poland. |
| Jul 28, 2022 | Signed | Cole Kirschsieper | — | Miami Marlins | Miami Marlins signed LHP Cole Kirschsieper. |
| Jul 28, 2022 | Signed | Karson Milbrandt | — | Miami Marlins | Miami Marlins signed RHP Karson Milbrandt. |
| Jul 28, 2022 | Signed as free agent | Brad Malm | — | New York Mets | New York Mets signed free agent 3B Brad Malm to a minor league contract. |
| Jul 28, 2022 | Signed | Trevor Martin | — | Tampa Bay Rays | Tampa Bay Rays signed RHP Trevor Martin. |
| Jul 28, 2022 | Signed | Chris Villaman | — | Tampa Bay Rays | Tampa Bay Rays signed LHP Chris Villaman. |
| Jul 28, 2022 | Signed as free agent | Anderson Beltre | — | New York Mets | New York Mets signed free agent RHP Anderson Beltre to a minor league contract. |
| Jul 27, 2022 | Signed | Blade Tidwell | — | New York Mets | New York Mets signed RHP Blade Tidwell. |
| Jul 27, 2022 | Signed | Nick Morabito | — | New York Mets | New York Mets signed OF Nick Morabito. |
| Jul 27, 2022 | Signed | Jacob Reimer | — | New York Mets | New York Mets signed 3B Jacob Reimer. |
| Jul 27, 2022 | Signed | John Lynch | — | St. Louis Cardinals | St. Louis Cardinals signed LHP John Lynch. |
| Jul 27, 2022 | Signed | Brock Porter | — | Texas Rangers | Texas Rangers signed RHP Brock Porter. |
| Jul 27, 2022 | Signed | Jackson Holliday | — | Baltimore Orioles | Baltimore Orioles signed SS Jackson Holliday. |
| Jul 27, 2022 | Signed | Michael Kennedy | — | Pittsburgh Pirates | Pittsburgh Pirates signed LHP Michael Kennedy. |
| Jul 27, 2022 | Signed | Miguel Fulgencio | — | Pittsburgh Pirates | Pittsburgh Pirates signed LHP Miguel Fulgencio. |
| Jul 27, 2022 | Signed as free agent | Ryan Velazquez | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent RHP Ryan Velazquez to a minor league contract. |
| Jul 27, 2022 | Trade | Andrew Benintendi | Kansas City Royals | New York Yankees | Kansas City Royals traded LF Andrew Benintendi to New York Yankees for RHP Chandler Champlain, LHP T.J. Sikkema and RHP Beck Way. |
| Jul 27, 2022 | Signed as free agent | Jacob Campbell | — | San Diego Padres | San Diego Padres signed free agent C Jacob Campbell to a minor league contract. |
| Jul 27, 2022 | Signed as free agent | Bernardo Zabala | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent C Bernardo Zabala to a minor league contract. |
| Jul 27, 2022 | Signed as free agent | Billy Corcoran | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Billy Corcoran to a minor league contract. |
| Jul 27, 2022 | Signed as free agent | Alexis Liebano | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Alexis Liebano to a minor league contract. |
| Jul 27, 2022 | Signed as free agent | Nick Merkel | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Nick Merkel to a minor league contract. |
| Jul 27, 2022 | Signed as free agent | Ryan Brady | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Ryan Brady to a minor league contract. |
| Jul 27, 2022 | Signed | Jordan Beck | — | Colorado Rockies | Colorado Rockies signed OF Jordan Beck. |
| Jul 27, 2022 | Signed | Sterlin Thompson | — | Colorado Rockies | Colorado Rockies signed OF Sterlin Thompson. |
| Jul 27, 2022 | Signed | Yeniel Laboy | — | Athletics | Oakland Athletics signed 3B Yeniel Laboy. |
| Jul 27, 2022 | Signed | Clark Elliott | — | Athletics | Oakland Athletics signed OF Clark Elliott. |
| Jul 27, 2022 | Signed | John Michael Bertrand | — | San Francisco Giants | San Francisco Giants signed LHP John Bertrand. |
| Jul 27, 2022 | Signed as free agent | Garrett Apker | — | Detroit Tigers | Detroit Tigers signed free agent RHP Garrett Apker to a minor league contract. |
| Jul 27, 2022 | Signed as free agent | Garrett Irvin | — | Athletics | Oakland Athletics signed free agent LHP Garrett Irvin to a minor league contract. |
| Jul 27, 2022 | Signed | Dylan O'Rae | — | Milwaukee Brewers | Milwaukee Brewers signed SS Dylan O'Rae. |
| Jul 27, 2022 | Signed | Cam Schlittler | — | New York Yankees | New York Yankees signed RHP Cam Schlittler. |
| Jul 27, 2022 | Signed | Chris Williams Jr. | — | Detroit Tigers | Detroit Tigers signed OF Chris Williams Jr.. |
| Jul 27, 2022 | Signed | Jackson Cox | — | Colorado Rockies | Colorado Rockies signed RHP Jackson Cox. |
| Jul 27, 2022 | Signed | Carson Palmquist | — | Colorado Rockies | Colorado Rockies signed LHP Carson Palmquist. |
| Jul 27, 2022 | Signed | Michael Prosecky | — | Colorado Rockies | Colorado Rockies signed LHP Michael Prosecky. |
| Jul 27, 2022 | Signed | Connor Staine | — | Colorado Rockies | Colorado Rockies signed RHP Connor Staine. |
| Jul 27, 2022 | Signed as free agent | Manuel Heredia | — | Texas Rangers | Texas Rangers signed free agent RHP Manuel Heredia to a minor league contract. |
| Jul 26, 2022 | Signed | Tres Gonzalez | — | Pittsburgh Pirates | Pittsburgh Pirates signed OF Tres Gonzalez. |
| Jul 26, 2022 | Signed | Derek Diamond | — | Pittsburgh Pirates | Pittsburgh Pirates signed RHP Derek Diamond. |
| Jul 26, 2022 | Signed | J.P. Massey | — | Pittsburgh Pirates | Pittsburgh Pirates signed RHP J.P. Massey. |
| Jul 26, 2022 | Signed | Michael Walsh | — | Pittsburgh Pirates | Pittsburgh Pirates signed RHP Mike Walsh. |
| Jul 26, 2022 | Signed | Dominic Perachi | — | Pittsburgh Pirates | Pittsburgh Pirates signed LHP Dominic Perachi. |
| Jul 26, 2022 | Signed | Joshua Loeschorn | — | Pittsburgh Pirates | Pittsburgh Pirates signed RHP Joshua Loeschorn. |
| Jul 26, 2022 | Signed as free agent | Dallas Keuchel | — | Texas Rangers | Texas Rangers signed free agent LHP Dallas Keuchel to a minor league contract. |
| Jul 26, 2022 | Signed | Drew Gilbert | — | Houston Astros | Houston Astros signed OF Drew Gilbert. |
| Jul 26, 2022 | Signed | Jacob Melton | — | Houston Astros | Houston Astros signed OF Jacob Melton. |
| Jul 26, 2022 | Signed | Brett Gillis | — | Houston Astros | Houston Astros signed RHP Brett Gillis. |
| Jul 26, 2022 | Signed | Mikey Romero | — | Boston Red Sox | Boston Red Sox signed SS Mikey Romero. |
| Jul 26, 2022 | Signed | Cutter Coffey | — | Boston Red Sox | Boston Red Sox signed SS Cutter Coffey. |
| Jul 26, 2022 | Signed | Alex Hoppe | — | Boston Red Sox | Boston Red Sox signed RHP Alex Hoppe. |
| Jul 26, 2022 | Signed | Caleb Bolden | — | Boston Red Sox | Boston Red Sox signed RHP Caleb Bolden. |
| Jul 26, 2022 | Signed | Jonathan Brand | — | Boston Red Sox | Boston Red Sox signed RHP Jonathan Brand. |
| Jul 26, 2022 | Signed | Isaac Coffey | — | Boston Red Sox | Boston Red Sox signed RHP Isaac Coffey. |
| Jul 26, 2022 | Signed | Kumar Rocker | — | Texas Rangers | Texas Rangers signed RHP Kumar Rocker. |
| Jul 26, 2022 | Trade | Ben Bowden | Tampa Bay Rays | San Francisco Giants | Tampa Bay Rays traded LHP Ben Bowden to San Francisco Giants. |
| Jul 26, 2022 | Signed | Max Wagner | — | Baltimore Orioles | Baltimore Orioles signed 3B Max Wagner. |
| Jul 26, 2022 | Signed | Brandon Barriera | — | Toronto Blue Jays | Toronto Blue Jays signed LHP Brandon Barriera. |
| Jul 26, 2022 | Signed | Josh Kasevich | — | Toronto Blue Jays | Toronto Blue Jays signed SS Josh Kasevich. |
| Jul 26, 2022 | Signed | Tucker Toman | — | Toronto Blue Jays | Toronto Blue Jays signed SS Tucker Toman. |
| Jul 26, 2022 | Signed | Cade Doughty | — | Toronto Blue Jays | Toronto Blue Jays signed 2B Cade Doughty. |
| Jul 26, 2022 | Signed | Alan Roden | — | Toronto Blue Jays | Toronto Blue Jays signed OF Alan Roden. |
| Jul 26, 2022 | Signed | Ryan Jennings | — | Toronto Blue Jays | Toronto Blue Jays signed RHP Ryan Jennings. |
| Jul 26, 2022 | Signed | Mason Fluharty | — | Toronto Blue Jays | Toronto Blue Jays signed LHP Mason Fluharty. |
| Jul 26, 2022 | Signed | T.J. Brock | — | Toronto Blue Jays | Toronto Blue Jays signed RHP T.J. Brock. |
| Jul 26, 2022 | Signed | Peyton Williams | — | Toronto Blue Jays | Toronto Blue Jays signed 1B Peyton Williams. |
| Jul 26, 2022 | Signed | Dylan Rock | — | Toronto Blue Jays | Toronto Blue Jays signed OF Dylan Rock. |
| Jul 26, 2022 | Signed | Devereaux Harrison | — | Toronto Blue Jays | Toronto Blue Jays signed RHP Devereaux Harrison. |
| Jul 26, 2022 | Signed | Ian Churchill | — | Toronto Blue Jays | Toronto Blue Jays signed LHP Ian Churchill. |
| Jul 26, 2022 | Signed | Pat Gallagher | — | Toronto Blue Jays | Toronto Blue Jays signed RHP Pat Gallagher. |
| Jul 26, 2022 | Signed | Nolan Perry | — | Toronto Blue Jays | Toronto Blue Jays signed RHP Nolan Perry. |
| Jul 26, 2022 | Signed | Bo Bonds | — | Toronto Blue Jays | Toronto Blue Jays signed RHP Bo Bonds. |
| Jul 26, 2022 | Signed | Sammy Hernandez | — | Toronto Blue Jays | Toronto Blue Jays signed C Sammy Hernandez. |
| Jul 26, 2022 | Signed | Michael Turconi | — | Toronto Blue Jays | Toronto Blue Jays signed SS Michael Turconi. |
| Jul 26, 2022 | Signed | Ryan Chasse | — | Toronto Blue Jays | Toronto Blue Jays signed LHP Ryan Chasse. |
| Jul 26, 2022 | Signed as free agent | Alex Amalfi | — | Toronto Blue Jays | Toronto Blue Jays signed free agent RHP Alex Amalfi to a minor league contract. |
| Jul 26, 2022 | Signed as free agent | Ryan McCarty | — | Toronto Blue Jays | Toronto Blue Jays signed free agent SS Ryan McCarty to a minor league contract. |
| Jul 26, 2022 | Signed as free agent | Devonte Brown | — | Toronto Blue Jays | Toronto Blue Jays signed free agent OF Devonte Brown to a minor league contract. |
| Jul 26, 2022 | Signed | Curtis Washington Jr. | — | Seattle Mariners | Seattle Mariners signed OF Curtis Washington Jr.. |
| Jul 26, 2022 | Signed | Hogan Windish | — | Seattle Mariners | Seattle Mariners signed 2B Hogan Windish. |
| Jul 26, 2022 | Signed | Matt Brosky | — | Texas Rangers | Texas Rangers signed RHP Matt Brosky. |
| Jul 26, 2022 | Signed | Griffin Cheney | — | Texas Rangers | Texas Rangers signed SS Griffin Cheney. |
| Jul 26, 2022 | Signed | Josh Hatcher | — | Texas Rangers | Texas Rangers signed OF Josh Hatcher. |
| Jul 26, 2022 | Signed | Kohl Drake | — | Texas Rangers | Texas Rangers signed LHP Kohl Drake. |
| Jul 26, 2022 | Signed | Jackson Kelley | — | Texas Rangers | Texas Rangers signed RHP Jackson Kelley. |
| Jul 26, 2022 | Signed | Justin Sanchez | — | Texas Rangers | Texas Rangers signed LHP Justin Sanchez. |
| Jul 26, 2022 | Signed | Seth Clark | — | Texas Rangers | Texas Rangers signed LHP Seth Clark. |
| Jul 26, 2022 | Signed as free agent | Jacob Maton | — | Texas Rangers | Texas Rangers signed free agent RHP Jacob Maton to a minor league contract. |
| Jul 26, 2022 | Signed as free agent | Vinny Nittoli | — | Toronto Blue Jays | Toronto Blue Jays signed free agent RHP Vinny Nittoli to a minor league contract. |
| Jul 26, 2022 | Signed | Cole Young | — | Seattle Mariners | Seattle Mariners signed SS Cole Young. |
| Jul 26, 2022 | Signed | Tyler Locklear | — | Seattle Mariners | Seattle Mariners signed 3B Tyler Locklear. |
| Jul 26, 2022 | Signed | Walter Ford | — | Seattle Mariners | Seattle Mariners signed RHP Walter Ford. |
| Jul 26, 2022 | Signed | Ashton Izzi | — | Seattle Mariners | Seattle Mariners signed RHP Ashton Izzi. |
| Jul 26, 2022 | Signed | Reid VanScoter | — | Seattle Mariners | Seattle Mariners signed LHP Reid VanScoter. |
| Jul 26, 2022 | Signed | Josh Hood | — | Seattle Mariners | Seattle Mariners signed SS Josh Hood. |
| Jul 26, 2022 | Signed | Tatem Levins | — | Seattle Mariners | Seattle Mariners signed C Tatem Levins. |
| Jul 26, 2022 | Signed | Tyler Gough | — | Seattle Mariners | Seattle Mariners signed RHP Tyler Gough. |
| Jul 26, 2022 | Signed | Bill Knight | — | Seattle Mariners | Seattle Mariners signed OF Bill Knight. |
| Jul 26, 2022 | Signed | Marcelo Perez | — | Seattle Mariners | Seattle Mariners signed RHP Marcelo Perez. |
| Jul 26, 2022 | Signed | Troy Taylor | — | Seattle Mariners | Seattle Mariners signed RHP Troy Taylor. |
| Jul 26, 2022 | Signed | Darren Bowen | — | Seattle Mariners | Seattle Mariners signed RHP Darren Bowen. |
| Jul 26, 2022 | Signed | Tyler Cleveland | — | Seattle Mariners | Seattle Mariners signed RHP Tyler Cleveland. |
| Jul 26, 2022 | Signed | Blake Rambusch | — | Seattle Mariners | Seattle Mariners signed 3B Blake Rambusch. |
| Jul 26, 2022 | Signed | Stefan Raeth | — | Seattle Mariners | Seattle Mariners signed RHP Stefan Raeth. |
| Jul 26, 2022 | Signed | Brandon Schaeffer | — | Seattle Mariners | Seattle Mariners signed LHP Brandon Schaeffer. |
| Jul 26, 2022 | Signed | Nick Zona | — | Seattle Mariners | Seattle Mariners signed 2B Nick Zona. |
| Jul 26, 2022 | Signed as free agent | Connor Charping | — | Seattle Mariners | Seattle Mariners signed free agent C Connor Charping to a minor league contract. |
| Jul 26, 2022 | Signed | Tanner Tredaway | — | Pittsburgh Pirates | Pittsburgh Pirates signed OF Tanner Tredaway. |
| Jul 26, 2022 | Signed | Nick Cimillo | — | Pittsburgh Pirates | Pittsburgh Pirates signed C Nick Cimillo. |
| Jul 26, 2022 | Signed | Jaycob Deese | — | Pittsburgh Pirates | Pittsburgh Pirates signed RHP Jaycob Deese. |
| Jul 26, 2022 | Signed | Elijah Birdsong | — | Pittsburgh Pirates | Pittsburgh Pirates signed RHP Elijah Birdsong. |
| Jul 26, 2022 | Signed | Silas Ardoin | — | Baltimore Orioles | Baltimore Orioles signed C Silas Ardoin. |
| Jul 26, 2022 | Signed | Douglas Hodo III | — | Baltimore Orioles | Baltimore Orioles signed OF Douglas Hodo III. |
| Jul 26, 2022 | Signed | Trace Bright | — | Baltimore Orioles | Baltimore Orioles signed RHP Trace Bright. |
| Jul 26, 2022 | Signed | Preston Johnson | — | Baltimore Orioles | Baltimore Orioles signed RHP Preston Johnson. |
| Jul 26, 2022 | Signed | Cameron Weston | — | Baltimore Orioles | Baltimore Orioles signed RHP Cameron Weston. |
| Jul 26, 2022 | Signed | Adam Crampton | — | Baltimore Orioles | Baltimore Orioles signed SS Adam Crampton. |
| Jul 26, 2022 | Signed | Wyatt Cheney | — | Baltimore Orioles | Baltimore Orioles signed RHP Wyatt Cheney. |
| Jul 26, 2022 | Signed | Bradley Brehmer | — | Baltimore Orioles | Baltimore Orioles signed RHP Bradley Brehmer. |
| Jul 26, 2022 | Signed | Jared Beck | — | Baltimore Orioles | Baltimore Orioles signed LHP Jared Beck. |
| Jul 26, 2022 | Signed | Adam Retzbach | — | Baltimore Orioles | Baltimore Orioles signed C Adam Retzbach. |
| Jul 26, 2022 | Signed | Graham Firoved | — | Baltimore Orioles | Baltimore Orioles signed RHP Graham Firoved. |
| Jul 26, 2022 | Signed | Reese Sharp | — | Baltimore Orioles | Baltimore Orioles signed RHP Reese Sharp. |
| Jul 26, 2022 | Signed | Brooks Lee | — | Minnesota Twins | Minnesota Twins signed SS Brooks Lee. |
| Jul 26, 2022 | Signed | Connor Prielipp | — | Minnesota Twins | Minnesota Twins signed LHP Connor Prielipp. |
| Jul 26, 2022 | Signed | Tanner Schobel | — | Minnesota Twins | Minnesota Twins signed SS Tanner Schobel. |
| Jul 26, 2022 | Signed | Andrew Morris | — | Minnesota Twins | Minnesota Twins signed RHP Andrew Morris. |
| Jul 26, 2022 | Signed | Ben Ross | — | Minnesota Twins | Minnesota Twins signed SS Ben Ross. |
| Jul 26, 2022 | Signed | Jorel Ortega | — | Minnesota Twins | Minnesota Twins signed 2B Jorel Ortega. |
| Jul 26, 2022 | Signed | Kyle Jones | — | Minnesota Twins | Minnesota Twins signed RHP Kyle Jones. |
| Jul 26, 2022 | Signed | Zebby Matthews | — | Minnesota Twins | Minnesota Twins signed RHP Zebby Matthews. |
| Jul 26, 2022 | Signed | Cory Lewis | — | Minnesota Twins | Minnesota Twins signed RHP Cory Lewis. |
| Jul 26, 2022 | Signed | Dalton Shuffield | — | Minnesota Twins | Minnesota Twins signed SS Dalton Shuffield. |
| Jul 26, 2022 | Signed | Andrew Cossetti | — | Minnesota Twins | Minnesota Twins signed C Andrew Cossetti. |
| Jul 26, 2022 | Signed | Nate Baez | — | Minnesota Twins | Minnesota Twins signed C Nate Baez. |
| Jul 26, 2022 | Signed | C.J. Culpepper | — | Minnesota Twins | Minnesota Twins signed RHP C.J. Culpepper. |
| Jul 26, 2022 | Signed | Ben Ethridge | — | Minnesota Twins | Minnesota Twins signed RHP Ben Ethridge. |
| Jul 26, 2022 | Signed | Jankel Ortiz | — | Minnesota Twins | Minnesota Twins signed SS Jankel Ortiz. |
| Jul 26, 2022 | Signed | Alec Sayre | — | Minnesota Twins | Minnesota Twins signed OF Alec Sayre. |
| Jul 26, 2022 | Signed | Zach Veen | — | Minnesota Twins | Minnesota Twins signed LHP Zachary Veen. |
| Jul 26, 2022 | Signed | Landon Sims | — | Arizona Diamondbacks | Arizona Diamondbacks signed RHP Landon Sims. |
| Jul 26, 2022 | Signed | Ivan Melendez | — | Arizona Diamondbacks | Arizona Diamondbacks signed 1B Ivan Melendez. |
| Jul 26, 2022 | Signed | Nate Savino | — | Arizona Diamondbacks | Arizona Diamondbacks signed LHP Nate Savino. |
| Jul 26, 2022 | Signed | Andrew Pintar | — | Arizona Diamondbacks | Arizona Diamondbacks signed SS Andrew Pintar. |
| Jul 26, 2022 | Signed | Daniel Norris | — | Detroit Tigers | Detroit Tigers signed LHP Daniel Norris. |
| Jul 26, 2022 | Signed | Javier Vaz | — | Kansas City Royals | Kansas City Royals signed OF Javier Vaz. |
| Jul 26, 2022 | Signed as free agent | Maxwell Costes | — | Baltimore Orioles | Baltimore Orioles signed free agent 1B Maxwell Costes to a minor league contract. |
| Jul 26, 2022 | Signed | Daniel Susac | — | Athletics | Oakland Athletics signed C Daniel Susac. |
| Jul 26, 2022 | Signed as free agent | Tyler Rando | — | Miami Marlins | Miami Marlins signed free agent C Tyler Rando to a minor league contract. |
| Jul 26, 2022 | Signed as free agent | Harrison Spohn | — | Miami Marlins | Miami Marlins signed free agent SS Harrison Spohn to a minor league contract. |
| Jul 26, 2022 | Signed as free agent | Michael Darrell-Hicks | — | Los Angeles Angels | Los Angeles Angels signed free agent RHP Michael Darrell-Hicks to a minor league contract. |
| Jul 26, 2022 | Signed | Jackson Fristoe | — | New York Yankees | New York Yankees signed RHP Jackson Fristoe. |
| Jul 26, 2022 | Signed | Chase Hampton | — | New York Yankees | New York Yankees signed RHP Chase Hampton. |
| Jul 26, 2022 | Signed | Joe Adametz | — | Detroit Tigers | Detroit Tigers signed LHP Joe Adametz. |
| Jul 26, 2022 | Signed | Albert Oliva | — | Detroit Tigers | Detroit Tigers signed RHP Albert Oliva. |
| Jul 26, 2022 | Signed as free agent | Colin Fields | — | Detroit Tigers | Detroit Tigers signed free agent RHP Colin Fields to a minor league contract. |
| Jul 26, 2022 | Signed as free agent | Max Alba | — | Detroit Tigers | Detroit Tigers signed free agent RHP Max Alba. |
| Jul 26, 2022 | Signed | Jack Gowen | — | Miami Marlins | Miami Marlins signed RHP Jack Gowen. |
| Jul 26, 2022 | Signed | Jared Lyons | — | Cincinnati Reds | Cincinnati Reds signed RHP Jared Lyons. |
| Jul 25, 2022 | Signed | Justin Crawford | — | Philadelphia Phillies | Philadelphia Phillies signed OF Justin Crawford. |
| Jul 25, 2022 | Signed | Gabriel Rincones Jr. | — | Philadelphia Phillies | Philadelphia Phillies signed OF Gabriel Rincones Jr.. |
| Jul 25, 2022 | Signed | Orion Kerkering | — | Philadelphia Phillies | Philadelphia Phillies signed RHP Orion Kerkering. |
| Jul 25, 2022 | Signed | Mavis Graves | — | Philadelphia Phillies | Philadelphia Phillies signed LHP Mavis Graves. |
| Jul 25, 2022 | Signed | Caleb Ricketts | — | Philadelphia Phillies | Philadelphia Phillies signed C Caleb Ricketts. |
| Jul 25, 2022 | Signed | Alex Rao | — | Philadelphia Phillies | Philadelphia Phillies signed RHP Alex Rao. |
| Jul 25, 2022 | Signed | Chad Castillo | — | Philadelphia Phillies | Philadelphia Phillies signed OF Chad Castillo. |
| Jul 25, 2022 | Signed | Gustavo Sosa | — | Philadelphia Phillies | Philadelphia Phillies signed C Gustavo Sosa. |
| Jul 25, 2022 | Signed | Jordan Dissin | — | Philadelphia Phillies | Philadelphia Phillies signed C Jordan Dissin. |
| Jul 25, 2022 | Signed | Cade Fergus | — | Philadelphia Phillies | Philadelphia Phillies signed OF Cade Fergus. |
| Jul 25, 2022 | Signed | Bryan Rincon | — | Philadelphia Phillies | Philadelphia Phillies signed SS Bryan Rincon. |
| Jul 25, 2022 | Signed | Troy Schreffler Jr. | — | Philadelphia Phillies | Philadelphia Phillies signed OF Troy Schreffler. |
| Jul 25, 2022 | Signed | Josh Bortka | — | Philadelphia Phillies | Philadelphia Phillies signed RHP Josh Bortka. |
| Jul 25, 2022 | Signed | Daniel Harper | — | Philadelphia Phillies | Philadelphia Phillies signed RHP Daniel Harper. |
| Jul 25, 2022 | Signed | Drew Garrett | — | Philadelphia Phillies | Philadelphia Phillies signed RHP Drew Garrett. |
| Jul 25, 2022 | Signed as free agent | Ezra Farmer | — | Philadelphia Phillies | Philadelphia Phillies signed free agent OF Ezra Farmer to a minor league contract. |
| Jul 25, 2022 | Signed as free agent | Mason Ronan | — | Philadelphia Phillies | Philadelphia Phillies signed free agent LHP Mason Ronan to a minor league contract. |
| Jul 25, 2022 | Signed as free agent | Danny Wilkinson | — | Philadelphia Phillies | Philadelphia Phillies signed free agent LHP Danny Wilkinson to a minor league contract. |
| Jul 25, 2022 | Signed as free agent | Matt Alifano | — | Philadelphia Phillies | Philadelphia Phillies signed free agent 3B Matt Alifano to a minor league contract. |
| Jul 25, 2022 | Signed as free agent | Dakota Kotowski | — | Philadelphia Phillies | Philadelphia Phillies signed free agent OF Dakota Kotowski to a minor league contract. |
| Jul 25, 2022 | Trade | Abraham Almonte | Milwaukee Brewers | Boston Red Sox | Milwaukee Brewers traded CF Abraham Almonte to Boston Red Sox for cash. |
| Jul 25, 2022 | Signed | Spencer Jones | — | New York Yankees | New York Yankees signed OF Spencer Jones. |
| Jul 25, 2022 | Signed | Drew Thorpe | — | New York Yankees | New York Yankees signed RHP Drew Thorpe. |
| Jul 25, 2022 | Signed | Trystan Vrieling | — | New York Yankees | New York Yankees signed RHP Trystan Vrieling. |
| Jul 25, 2022 | Signed | Anthony Hall | — | New York Yankees | New York Yankees signed OF Anthony Hall. |
| Jul 25, 2022 | Signed | Eric Reyzelman | — | New York Yankees | New York Yankees signed RHP Eric Reyzelman. |
| Jul 25, 2022 | Signed as free agent | Jacob Barnes | — | Detroit Tigers | Detroit Tigers signed free agent RHP Jacob Barnes to a minor league contract. |
| Jul 25, 2022 | Signed as free agent | Giullianno Allende | — | Kansas City Royals | Kansas City Royals signed free agent OF Giullianno Allende to a minor league contract. |
| Jul 25, 2022 | Signed as free agent | Chase Anderson | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP Chase Anderson to a minor league contract. |
| Jul 25, 2022 | Signed | Logan Clayton | — | Arizona Diamondbacks | Arizona Diamondbacks signed RHP Logan Clayton. |
| Jul 25, 2022 | Signed as free agent | Zion Pettigrew | — | Washington Nationals | Washington Nationals signed free agent 3B Zion Pettigrew to a minor league contract. |
| Jul 25, 2022 | Signed as free agent | Saul Arias | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Saul Arias to a minor league contract. |
| Jul 25, 2022 | Signed as free agent | Guillermo Rosario | — | Philadelphia Phillies | Philadelphia Phillies signed free agent C Guillermo Rosario to a minor league contract. |
| Jul 25, 2022 | Signed as free agent | John McHenry | — | Washington Nationals | Washington Nationals signed free agent 2B John McHenry. |
| Jul 25, 2022 | Signed as free agent | Ben Beutel | — | Chicago White Sox | Chicago White Sox signed free agent LHP Ben Beutel to a minor league contract. |
| Jul 25, 2022 | Signed | Ethan Hammerberg | — | Chicago White Sox | Chicago White Sox signed RHP Ethan Hammerberg. |
| Jul 25, 2022 | Signed | Tyler Schweitzer | — | Chicago White Sox | Chicago White Sox signed LHP Tyler Schweitzer. |
| Jul 25, 2022 | Signed | Jacob Burke | — | Chicago White Sox | Chicago White Sox signed OF Jacob Burke. |
| Jul 25, 2022 | Signed | Shane Murphy | — | Chicago White Sox | Chicago White Sox signed LHP Shane Murphy. |
| Jul 25, 2022 | Signed | Billy Seidl | — | Chicago White Sox | Chicago White Sox signed RHP Billy Seidl. |
| Jul 25, 2022 | Signed | Bryce Willits | — | Chicago White Sox | Chicago White Sox signed 3B Bryce Willits. |
| Jul 25, 2022 | Signed as free agent | Joey Gerber | — | New York Yankees | New York Yankees signed free agent RHP Joey Gerber to a minor league contract. |
| Jul 25, 2022 | Signed | Kody Huff | — | Colorado Rockies | Colorado Rockies signed C Kody Huff. |
| Jul 25, 2022 | Signed | Skyler Messinger | — | Colorado Rockies | Colorado Rockies signed 3B Skyler Messinger. |
| Jul 25, 2022 | Signed | Parker Kelly | — | Colorado Rockies | Colorado Rockies signed 3B Parker Kelly. |
| Jul 25, 2022 | Signed | Brad Cumbest | — | Colorado Rockies | Colorado Rockies signed OF Brad Cumbest. |
| Jul 25, 2022 | Signed | Henry Bolte | — | Athletics | Oakland Athletics signed OF Henry Bolte. |
| Jul 25, 2022 | Signed | Jace Jung | — | Detroit Tigers | Detroit Tigers signed 2B Jace Jung. |
| Jul 25, 2022 | Signed | Michael Sansone | — | Tampa Bay Rays | Tampa Bay Rays signed LHP Michael Sansone. |
| Jul 25, 2022 | Signed | Jack Perkins | — | Athletics | Oakland Athletics signed RHP Jack Perkins. |
| Jul 25, 2022 | Signed | Roel Garcia III | — | Tampa Bay Rays | Tampa Bay Rays signed RHP Roel Garcia III. |
| Jul 25, 2022 | Signed | Cade Halemanu | — | Tampa Bay Rays | Tampa Bay Rays signed RHP Cade Halemanu. |
| Jul 25, 2022 | Signed | Geoffrey Gilbert | — | New York Yankees | New York Yankees signed LHP Geoffrey Gilbert. |
| Jul 25, 2022 | Signed | Ryan Harvey | — | New York Yankees | New York Yankees signed RHP Ryan Harvey. |
| Jul 25, 2022 | Signed as free agent | Kevin Stevens | — | New York Yankees | New York Yankees signed free agent RHP Kevin Stevens to a minor league contract. |
| Jul 25, 2022 | Signed as free agent | Rafael Flores Jr. | — | New York Yankees | New York Yankees signed free agent C Rafael Flores to a minor league contract. |
| Jul 25, 2022 | Signed as free agent | Alex Bustamante | — | New York Yankees | New York Yankees signed free agent RHP Alex Bustamante to a minor league contract. |
| Jul 25, 2022 | Signed | Cam Collier | — | Cincinnati Reds | Cincinnati Reds signed 3B Cam Collier. |
| Jul 25, 2022 | Signed | Jake Pfennigs | — | Athletics | Oakland Athletics signed RHP Jake Pfennigs. |
| Jul 25, 2022 | Signed | Zach Agnos | — | Colorado Rockies | Colorado Rockies signed RHP Zach Agnos. |
| Jul 25, 2022 | Signed | Austin Becker | — | Colorado Rockies | Colorado Rockies signed RHP Austin Becker. |
| Jul 25, 2022 | Signed | Caleb Franzen | — | Colorado Rockies | Colorado Rockies signed LHP Caleb Franzen. |
| Jul 25, 2022 | Signed | Brady Hill | — | Colorado Rockies | Colorado Rockies signed RHP Brady Hill. |
| Jul 25, 2022 | Signed | Tyler Hoffman | — | Colorado Rockies | Colorado Rockies signed RHP Tyler Hoffman. |
| Jul 25, 2022 | Signed | Braxton Hyde | — | Colorado Rockies | Colorado Rockies signed RHP Braxton Hyde. |
| Jul 25, 2022 | Signed | Davison Palermo | — | Colorado Rockies | Colorado Rockies signed RHP Davis Palermo. |
| Jul 25, 2022 | Signed | Carson Skipper | — | Colorado Rockies | Colorado Rockies signed LHP Carson Skipper. |
| Jul 25, 2022 | Signed as free agent | Jackson Lyon | — | New York Yankees | New York Yankees signed free agent OF Jackson Lyon to a minor league contract. |
| Jul 25, 2022 | Signed as free agent | Matt Archer | — | Chicago White Sox | Chicago White Sox signed free agent 2B Matt Archer to a minor league contract. |
| Jul 25, 2022 | Signed | Marcus Johnson | — | Miami Marlins | Miami Marlins signed RHP Marcus Johnson. |
| Jul 25, 2022 | Signed | Jake Christianson | — | Tampa Bay Rays | Tampa Bay Rays signed RHP Jake Christianson. |
| Jul 25, 2022 | Signed | Nate Dahle | — | Tampa Bay Rays | Tampa Bay Rays signed RHP Nate Dahle. |
| Jul 25, 2022 | Signed | Duncan Davitt | — | Tampa Bay Rays | Tampa Bay Rays signed RHP Duncan Davitt. |
| Jul 25, 2022 | Signed | Sean Harney | — | Tampa Bay Rays | Tampa Bay Rays signed RHP Sean Harney. |
| Jul 25, 2022 | Signed | Chazz Martinez | — | Kansas City Royals | Kansas City Royals signed LHP Chazz Martinez. |
| Jul 25, 2022 | Signed as free agent | Haden Erbe | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP Haden Erbe to a minor league contract. |
| Jul 25, 2022 | Signed | Joseph King | — | St. Louis Cardinals | St. Louis Cardinals signed RHP Joseph King. |
| Jul 25, 2022 | Signed | Alex Cook | — | Tampa Bay Rays | Tampa Bay Rays signed RHP Alex Cook. |
| Jul 25, 2022 | Signed as free agent | Drew Sommers | — | Tampa Bay Rays | Tampa Bay Rays signed free agent LHP Drew Sommers to a minor league contract. |
| Jul 24, 2022 | Signed as free agent | Hansel Robles | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Hansel Robles to a minor league contract. |
| Jul 24, 2022 | Signed | Cameron Masterman | — | Athletics | Oakland Athletics signed OF Cameron Masterman. |
| Jul 24, 2022 | Signed | Brennan Milone | — | Athletics | Oakland Athletics signed 3B Brennan Milone. |
| Jul 24, 2022 | Signed | Tommy Stevenson | — | Athletics | Oakland Athletics signed 1B Tommy Stevenson. |
| Jul 24, 2022 | Signed | Caeden Trenkle | — | Athletics | Oakland Athletics signed OF Caeden Trenkle. |
| Jul 24, 2022 | Signed | Jake Garland | — | Athletics | Oakland Athletics signed RHP Jake Garland. |
| Jul 24, 2022 | Signed as free agent | Jordan Woods | — | Kansas City Royals | Kansas City Royals signed free agent LHP Jordan Woods to a minor league contract. |
| Jul 24, 2022 | Signed | Mark Adamiak | — | Athletics | Oakland Athletics signed RHP Mark Adamiak. |
| Jul 24, 2022 | Signed | T.J. Czyz | — | Athletics | Oakland Athletics signed RHP T.J. Czyz. |
| Jul 24, 2022 | Signed | Micah Dallas | — | Athletics | Oakland Athletics signed RHP Micah Dallas. |
| Jul 24, 2022 | Signed | Blaze Pontes | — | Athletics | Oakland Athletics signed RHP Blaze Pontes. |
| Jul 24, 2022 | Signed | Vince Reilly | — | Athletics | Oakland Athletics signed RHP Vince Reilly. |
| Jul 24, 2022 | Signed | Ben Sears | — | Kansas City Royals | Kansas City Royals signed RHP Ben Sears. |
| Jul 24, 2022 | Signed | Cooper McKeehan | — | Kansas City Royals | Kansas City Royals signed LHP Cooper McKeehan. |
| Jul 24, 2022 | Signed as free agent | Nicholas Regalado | — | Kansas City Royals | Kansas City Royals signed free agent RHP Nicholas Regalado to a minor league contract. |
| Jul 24, 2022 | Signed | Milo Rushford | — | Kansas City Royals | Kansas City Royals signed OF Milo Rushford. |
| Jul 24, 2022 | Signed | Wesley Scott | — | Kansas City Royals | Kansas City Royals signed RHP Wesley Scott. |
| Jul 24, 2022 | Signed | Marcus Olivarez | — | Kansas City Royals | Kansas City Royals signed RHP Marcus Olivarez. |
| Jul 24, 2022 | Signed | Mason Barnett | — | Kansas City Royals | Kansas City Royals signed RHP Mason Barnett. |
| Jul 24, 2022 | Signed | Ryan Ramsey | — | Kansas City Royals | Kansas City Royals signed LHP Ryan Ramsey. |
| Jul 24, 2022 | Signed | David Sandlin | — | Kansas City Royals | Kansas City Royals signed RHP David Sandlin. |
| Jul 24, 2022 | Signed | Mack Anglin | — | Kansas City Royals | Kansas City Royals signed RHP Mack Anglin. |
| Jul 24, 2022 | Signed as free agent | Brett Squires | — | Kansas City Royals | Kansas City Royals signed free agent 3B Brett Squires to a minor league contract. |
| Jul 24, 2022 | Signed | Steven Zobac | — | Kansas City Royals | Kansas City Royals signed RHP Steven Zobac. |
| Jul 24, 2022 | Signed as free agent | Cade Winquest | — | St. Louis Cardinals | St. Louis Cardinals signed free agent RHP Cade Winquest to a minor league contract. |
| Jul 23, 2022 | Signed | Trey Dombroski | — | Houston Astros | Houston Astros signed LHP Trey Dombroski. |
| Jul 23, 2022 | Signed as free agent | Michael Feliz | — | Minnesota Twins | Minnesota Twins signed free agent RHP Michael Feliz to a minor league contract. |
| Jul 23, 2022 | Trade | Michael Pérez | Pittsburgh Pirates | New York Mets | Pittsburgh Pirates traded C Michael Perez to New York Mets for cash. |
| Jul 23, 2022 | Signed | Cade Horton | — | Chicago Cubs | Chicago Cubs signed RHP Cade Horton. |
| Jul 23, 2022 | Signed | Christopher Paciolla | — | Chicago Cubs | Chicago Cubs signed SS Christopher Paciolla. |
| Jul 23, 2022 | Signed | Brandon Birdsell | — | Chicago Cubs | Chicago Cubs signed RHP Brandon Birdsell. |
| Jul 23, 2022 | Signed | Will Frisch | — | Chicago Cubs | Chicago Cubs signed RHP Will Frisch. |
| Jul 23, 2022 | Signed as free agent | Nick Hull | — | Chicago Cubs | Chicago Cubs signed free agent RHP Nick Hull to a minor league contract. |
| Jul 23, 2022 | Signed | Mason McGwire | — | Chicago Cubs | Chicago Cubs signed RHP Mason McGwire. |
| Jul 23, 2022 | Signed | Connor Noland | — | Chicago Cubs | Chicago Cubs signed RHP Connor Noland. |
| Jul 23, 2022 | Signed | Brody McCullough | — | Chicago Cubs | Chicago Cubs signed RHP Brody McCullough. |
| Jul 23, 2022 | Signed | Dylan Beavers | — | Baltimore Orioles | Baltimore Orioles signed OF Dylan Beavers. |
| Jul 23, 2022 | Signed | Jud Fabian | — | Baltimore Orioles | Baltimore Orioles signed OF Jud Fabian. |
| Jul 23, 2022 | Signed | Druw Jones | — | Arizona Diamondbacks | Arizona Diamondbacks signed OF Druw Jones. |
| Jul 23, 2022 | Signed as free agent | Jake McGee | — | Milwaukee Brewers | Milwaukee Brewers signed free agent LHP Jake McGee. |
| Jul 23, 2022 | Signed | Gavin Cross | — | Kansas City Royals | Kansas City Royals signed OF Gavin Cross. |
| Jul 23, 2022 | Signed | Noah Schultz | — | Chicago White Sox | Chicago White Sox signed LHP Noah Schultz. |
| Jul 23, 2022 | Signed as free agent | Bryant Zayas | — | Boston Red Sox | Boston Red Sox signed free agent SS Bryant Zayas to a minor league contract. |
| Jul 23, 2022 | Signed | Adrian Rodriguez | — | Arizona Diamondbacks | Arizona Diamondbacks signed SS Adrian Rodriguez. |
| Jul 23, 2022 | Signed | Brett Johnson | — | Arizona Diamondbacks | Arizona Diamondbacks signed OF Brett Johnson. |
| Jul 23, 2022 | Signed | David Martin | — | Arizona Diamondbacks | Arizona Diamondbacks signed C David Martin. |
| Jul 23, 2022 | Signed | Dale Stanavich | — | Miami Marlins | Miami Marlins signed LHP Dale Stanavich. |
| Jul 23, 2022 | Signed | Kyle Crigger | — | Miami Marlins | Miami Marlins signed RHP Kyle Crigger. |
| Jul 23, 2022 | Signed | Tristan Stevens | — | Miami Marlins | Miami Marlins signed RHP Tristan Stevens. |
| Jul 23, 2022 | Signed as free agent | Wyatt Wendell | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Wyatt Wendell to a minor league contract. |
| Jul 23, 2022 | Signed | Evan Taylor | — | Miami Marlins | Miami Marlins signed LHP Evan Taylor. |
| Jul 23, 2022 | Signed | Josh White | — | Miami Marlins | Miami Marlins signed RHP Josh White. |
| Jul 23, 2022 | Signed | Carmine Lane | — | Miami Marlins | Miami Marlins signed C Carmine Lane. |
| Jul 23, 2022 | Signed | Spencer Bramwell | — | Miami Marlins | Miami Marlins signed C Spencer Bramwell. |
| Jul 23, 2022 | Signed as free agent | Matt Pushard | — | Miami Marlins | Miami Marlins signed free agent RHP Matt Pushard to a minor league contract. |
| Jul 23, 2022 | Signed | Hayden Merda | — | New York Yankees | New York Yankees signed RHP Hayden Merda. |
| Jul 23, 2022 | Signed | Jake Palmer | — | New York Yankees | New York Yankees signed OF Jake Palmer. |
| Jul 23, 2022 | Signed as free agent | Josh Zamora | — | Miami Marlins | Miami Marlins signed free agent 3B Joshua Zamora to a minor league contract. |
| Jul 23, 2022 | Signed as free agent | Jahmai Jones | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent CF Jahmai Jones. |
| Jul 23, 2022 | Signed | Cade Hunter | — | Cincinnati Reds | Cincinnati Reds signed C Cade Hunter. |
| Jul 23, 2022 | Signed | Alex Williams | — | Miami Marlins | Miami Marlins signed RHP Alex Williams. |
| Jul 23, 2022 | Signed | Mason Pelio | — | Cincinnati Reds | Cincinnati Reds signed RHP Mason Pelio. |
| Jul 23, 2022 | Signed | Johnathan Harmon | — | Cincinnati Reds | Cincinnati Reds signed RHP Johnathan Harmon. |
| Jul 23, 2022 | Signed | Joseph Menefee | — | Cincinnati Reds | Cincinnati Reds signed LHP Joseph Menefee. |
| Jul 23, 2022 | Signed | Pete Hansen | — | St. Louis Cardinals | St. Louis Cardinals signed LHP Pete Hansen. |
| Jul 23, 2022 | Signed | Max Rajcic | — | St. Louis Cardinals | St. Louis Cardinals signed RHP Max Rajcic. |
| Jul 23, 2022 | Signed | Adam Serwinowski | — | Cincinnati Reds | Cincinnati Reds signed LHP Adam Serwinowski. |
| Jul 22, 2022 | Signed as free agent | David Dahl | — | Washington Nationals | Washington Nationals signed free agent LF David Dahl to a minor league contract. |
| Jul 22, 2022 | Signed as free agent | Daniel Ponce de Leon | — | Washington Nationals | Washington Nationals signed free agent RHP Daniel Ponce de Leon to a minor league contract. |
| Jul 22, 2022 | Signed as free agent | Andrew Knapp | — | San Francisco Giants | San Francisco Giants signed free agent C Andrew Knapp to a minor league contract. |
| Jul 22, 2022 | Signed as free agent | Errol Robinson | — | St. Louis Cardinals | St. Louis Cardinals signed free agent SS Errol Robinson to a minor league contract. |
| Jul 22, 2022 | Signed as free agent | Taylor Williams | — | Seattle Mariners | Seattle Mariners signed free agent RHP Taylor Williams to a minor league contract. |
| Jul 22, 2022 | Signed | Eric Brown Jr. | — | Milwaukee Brewers | Milwaukee Brewers signed SS Eric Brown Jr.. |
| Jul 22, 2022 | Trade | Daniel Vogelbach | Pittsburgh Pirates | New York Mets | Pittsburgh Pirates traded 1B Daniel Vogelbach to New York Mets. |
| Jul 22, 2022 | Trade | Colin Holderman | New York Mets | Pittsburgh Pirates | New York Mets traded RHP Colin Holderman to Pittsburgh Pirates. |
| Jul 22, 2022 | Released | Dallas Keuchel | — | Arizona Diamondbacks | Arizona Diamondbacks released LHP Dallas Keuchel. |
| Jul 22, 2022 | Released | Daniel Norris | — | Chicago Cubs | Chicago Cubs released LHP Daniel Norris. |
| Jul 22, 2022 | Signed as free agent | Wyatt Ulrich | — | San Diego Padres | San Diego Padres signed free agent OF Wyatt Ulrich to a minor league contract. |
| Jul 22, 2022 | Signed | Michael Knorr | — | Houston Astros | Houston Astros signed RHP Michael Knorr. |
| Jul 22, 2022 | Signed | Nolan DeVos | — | Houston Astros | Houston Astros signed RHP Nolan DeVos. |
| Jul 22, 2022 | Signed | Collin Price | — | Houston Astros | Houston Astros signed C Collin Price. |
| Jul 22, 2022 | Signed | AJ Blubaugh | — | Houston Astros | Houston Astros signed RHP A.J. Blubaugh. |
| Jul 22, 2022 | Signed | Tyler Guilfoil | — | Houston Astros | Houston Astros signed RHP Tyler Guilfoil. |
| Jul 22, 2022 | Signed | Zach Cole | — | Houston Astros | Houston Astros signed OF Zach Cole Jr.. |
| Jul 22, 2022 | Signed | Jackson Loftin | — | Houston Astros | Houston Astros signed SS Jackson Loftin. |
| Jul 22, 2022 | Signed | Jett Williams | — | New York Mets | New York Mets signed SS Jett Williams. |
| Jul 22, 2022 | Signed as free agent | Ben Gobbel | — | Los Angeles Angels | Los Angeles Angels signed free agent SS Ben Gobbel to a minor league contract. |
| Jul 22, 2022 | Signed | Peyton Graham | — | Detroit Tigers | Detroit Tigers signed SS Peyton Graham. |
| Jul 22, 2022 | Signed | Sebastian Keane | — | New York Yankees | New York Yankees signed RHP Sebastian Keane. |
| Jul 22, 2022 | Signed | Matt Keating | — | New York Yankees | New York Yankees signed RHP Matt Keating. |
| Jul 22, 2022 | Signed | Trevor Kirk | — | New York Yankees | New York Yankees signed RHP Trevor Kirk. |
| Jul 22, 2022 | Signed as free agent | Hueston Morrill | — | New York Yankees | New York Yankees signed free agent SS Hueston Morrill to a minor league contract. |
| Jul 22, 2022 | Signed as free agent | Adam Stone | — | New York Yankees | New York Yankees signed free agent RHP Adam Stone to a minor league contract. |
| Jul 22, 2022 | Signed | Joe Miller | — | Detroit Tigers | Detroit Tigers signed LHP Joe Miller. |
| Jul 22, 2022 | Signed | Patrick Pridgen | — | Detroit Tigers | Detroit Tigers signed RHP Patrick Pridgen. |
| Jul 22, 2022 | Signed | Quinn Gudaitis | — | Detroit Tigers | Detroit Tigers signed RHP Quinn Gudaitis. |
| Jul 22, 2022 | Signed | Jacob Miller | — | Miami Marlins | Miami Marlins signed RHP Jacob Miller. |
| Jul 22, 2022 | Signed | Kristófer Bow | — | New York Yankees | New York Yankees signed RHP Kris Bow. |
| Jul 22, 2022 | Signed | Justin Boyd | — | Cincinnati Reds | Cincinnati Reds signed OF Justin Boyd. |
| Jul 22, 2022 | Signed | Trey Faltine | — | Cincinnati Reds | Cincinnati Reds signed SS Trey Faltine. |
| Jul 22, 2022 | Signed | Sal Stewart | — | Cincinnati Reds | Cincinnati Reds signed 3B Sal Stewart. |
| Jul 22, 2022 | Signed | Logan Tanner | — | Cincinnati Reds | Cincinnati Reds signed C Logan Tanner. |
| Jul 22, 2022 | Signed as free agent | C.J. Mayhue | — | Los Angeles Angels | Los Angeles Angels signed free agent LHP C.J. Mayhue to a minor league contract. |
| Jul 22, 2022 | Signed | Cy Nielson | — | Pittsburgh Pirates | Pittsburgh Pirates signed LHP Cy Nielson. |
| Jul 22, 2022 | Signed | Brody Jessee | — | Cincinnati Reds | Cincinnati Reds signed RHP Brody Jessee. |
| Jul 22, 2022 | Signed | Thomas Harrington | — | Pittsburgh Pirates | Pittsburgh Pirates signed RHP Thomas Harrington. |
| Jul 22, 2022 | Signed | Hunter Barco | — | Pittsburgh Pirates | Pittsburgh Pirates signed LHP Hunter Barco. |
| Jul 22, 2022 | Signed | Cooper Hjerpe | — | St. Louis Cardinals | St. Louis Cardinals signed LHP Cooper Hjerpe. |
| Jul 22, 2022 | Signed | Brycen Mautz | — | St. Louis Cardinals | St. Louis Cardinals signed LHP Brycen Mautz. |
| Jul 22, 2022 | Signed | Kenya Huggins | — | Cincinnati Reds | Cincinnati Reds signed RHP Kenya Huggins. |
| Jul 22, 2022 | Signed | Chris McElvain | — | Cincinnati Reds | Cincinnati Reds signed RHP Chris McElvain. |
| Jul 22, 2022 | Signed | Ike Buxton | — | Miami Marlins | Miami Marlins signed RHP Ike Buxton. |
| Jul 21, 2022 | Signed as free agent | Roman Quinn | — | Tampa Bay Rays | Tampa Bay Rays signed free agent CF Roman Quinn. |
| Jul 21, 2022 | Signed | Tanner Jacobson | — | St. Louis Cardinals | St. Louis Cardinals signed RHP Tanner Jacobson. |
| Jul 21, 2022 | Signed as free agent | Trevor Rosenthal | — | San Francisco Giants | San Francisco Giants signed free agent RHP Trevor Rosenthal. |
| Jul 21, 2022 | Signed | Cole Phillips | — | Atlanta Braves | Atlanta Braves signed RHP Cole Phillips. |
| Jul 21, 2022 | Signed | Trey Lipscomb | — | Washington Nationals | Washington Nationals signed 3B Trey Lipscomb. |
| Jul 21, 2022 | Signed | Maxwell Romero Jr. | — | Washington Nationals | Washington Nationals signed C Maxwell Romero Jr.. |
| Jul 21, 2022 | Signed | Murphy Stehly | — | Washington Nationals | Washington Nationals signed 3B Murphy Stehly. |
| Jul 21, 2022 | Signed as free agent | Hamlet Peralta | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Hamlet Peralta to a minor league contract. |
| Jul 21, 2022 | Signed | Casey Dana | — | Los Angeles Angels | Los Angeles Angels signed OF Casey Dana. |
| Jul 21, 2022 | Signed | Luke Gold | — | Detroit Tigers | Detroit Tigers signed 3B Luke Gold. |
| Jul 21, 2022 | Signed | Andrew Jenkins | — | Detroit Tigers | Detroit Tigers signed 1B Andrew Jenkins. |
| Jul 21, 2022 | Signed | Jake Miller | — | Detroit Tigers | Detroit Tigers signed LHP Jake Miller. |
| Jul 21, 2022 | Signed as free agent | Baron Stuart | — | New York Yankees | New York Yankees signed free agent RHP Baron Stuart to a minor league contract. |
| Jul 21, 2022 | Signed as free agent | Angel Aybar | — | Houston Astros | Houston Astros signed free agent RHP Angel Aybar to a minor league contract. |
| Jul 20, 2022 | Signed as free agent | Tim Holdgrafer | — | Detroit Tigers | Detroit Tigers signed free agent RHP Tim Holdgrafer to a minor league contract. |
| Jul 20, 2022 | Signed as free agent | Matt Donlan | — | Boston Red Sox | Boston Red Sox signed free agent C Matt Donlan to a minor league contract. |
| Jul 20, 2022 | Signed as free agent | Joey Lancellotti | — | New York Mets | New York Mets signed free agent RHP Joey Lancellotti to a minor league contract. |
| Jul 20, 2022 | Signed | Zach Neto | — | Los Angeles Angels | Los Angeles Angels signed SS Zach Neto. |
| Jul 20, 2022 | Signed | Brendan Tinsman | — | Los Angeles Angels | Los Angeles Angels signed C Brendan Tinsman. |
| Jul 20, 2022 | Signed as free agent | Mason Holt | — | Los Angeles Angels | Los Angeles Angels signed free agent OF Mason Holt to a minor league contract. |
| Jul 20, 2022 | Signed | Danny Serretti | — | Detroit Tigers | Detroit Tigers signed SS Danny Serretti. |
| Jul 20, 2022 | Signed as free agent | Quinton Martinez | — | Los Angeles Angels | Los Angeles Angels signed free agent LHP Quinton Martinez to a minor league contract. |
| Jul 19, 2022 | Released | Zach Reks | — | Texas Rangers | Texas Rangers released OF Zach Reks. |
| Jul 19, 2022 | Signed as free agent | Chi Chi González | — | Detroit Tigers | Detroit Tigers signed free agent RHP Chi Chi Gonzalez to a minor league contract. |
| Jul 19, 2022 | Signed as free agent | Fernando Silvera | — | Houston Astros | Houston Astros signed free agent LHP Fernando Silvera to a minor league contract. |
| Jul 19, 2022 | Signed | Sonny DiChiara | — | Los Angeles Angels | Los Angeles Angels signed 1B Sonny DiChiara. |
| Jul 19, 2022 | Signed | Joe Stewart | — | Los Angeles Angels | Los Angeles Angels signed OF Joe Stewart. |
| Jul 19, 2022 | Signed as free agent | Evan Russell | — | Los Angeles Angels | Los Angeles Angels signed free agent C Evan Russell to a minor league contract. |
| Jul 19, 2022 | Signed | Levi Usher | — | Kansas City Royals | Kansas City Royals signed OF Levi Usher. |
| Jul 19, 2022 | Signed | Jack Alexander | — | Kansas City Royals | Kansas City Royals signed C Jack Alexander. |
| Jul 19, 2022 | Signed | Chandler Arnold | — | St. Louis Cardinals | St. Louis Cardinals signed RHP Chandler Arnold. |
| Jul 19, 2022 | Signed | D.J. Carpenter | — | St. Louis Cardinals | St. Louis Cardinals signed RHP D.J. Carpenter. |
| Jul 19, 2022 | Signed | Hunter Hayes | — | St. Louis Cardinals | St. Louis Cardinals signed RHP Hunter Hayes. |
| Jul 18, 2022 | Trade | Alex Young | Cleveland Guardians | San Francisco Giants | Cleveland Guardians traded LHP Alex Young to San Francisco Giants. |
| Jul 18, 2022 | Signed as free agent | Carlos Brito | — | New York Mets | New York Mets signed free agent RHP Carlos Brito to a minor league contract. |
| Jul 18, 2022 | Signed as free agent | Franyel Diaz | — | New York Mets | New York Mets signed free agent RHP Franyel Diaz to a minor league contract. |
| Jul 18, 2022 | Signed as free agent | Dee Strange-Gordon | — | Washington Nationals | Washington Nationals signed free agent 2B Dee Strange-Gordon to a minor league contract. |
| Jul 18, 2022 | Signed | Dylan Phillips | — | Los Angeles Angels | Los Angeles Angels signed TWP Dylan Phillips. |
| Jul 18, 2022 | Signed | Brandon Johnson | — | Kansas City Royals | Kansas City Royals signed RHP Brandon Johnson. |
| Jul 16, 2022 | Trade | Foster Griffin | Kansas City Royals | Toronto Blue Jays | Toronto Blue Jays traded RHP Jonatan Bernal to Kansas City Royals for LHP Foster Griffin. |
| Jul 16, 2022 | Trade | Matt Lipka | Washington Nationals | Milwaukee Brewers | Washington Nationals traded CF Matt Lipka to Milwaukee Brewers. |
| Jul 16, 2022 | Signed as free agent | Brooks Hall | — | New York Mets | New York Mets signed free agent RHP Brooks Hall to a minor league contract. |
| Jul 15, 2022 | Signed as free agent | Carson King | — | Baltimore Orioles | Baltimore Orioles signed free agent RHP Carson King to a minor league contract. |
| Jul 15, 2022 | Signed as free agent | Zade Richardson | — | Atlanta Braves | Atlanta Braves signed free agent C Zade Richardson to a minor league contract. |
| Jul 15, 2022 | Signed as free agent | Ricardo Quintana | — | Cincinnati Reds | Cincinnati Reds signed free agent RHP Ricardo Quintana to a minor league contract. |
| Jul 15, 2022 | Signed as free agent | Gabriel Gomes | — | Cincinnati Reds | Cincinnati Reds signed free agent C Gabriel Gomes to a minor league contract. |
| Jul 14, 2022 | Trade | Tyler Wade | Los Angeles Angels | New York Yankees | Los Angeles Angels traded 2B Tyler Wade to New York Yankees. |
| Jul 14, 2022 | Released | Jake McGee | — | San Francisco Giants | San Francisco Giants released LHP Jake McGee. |
| Jul 14, 2022 | Signed as free agent | Ben Heller | — | Minnesota Twins | Minnesota Twins signed free agent RHP Ben Heller to a minor league contract. |
| Jul 14, 2022 | Signed as free agent | Brock Stewart | — | Minnesota Twins | Minnesota Twins signed free agent RHP Brock Stewart to a minor league contract. |
| Jul 14, 2022 | Signed as free agent | Luis Colon | — | Houston Astros | Houston Astros signed free agent SS Luis Colon to a minor league contract. |
| Jul 13, 2022 | Signed as free agent | Sunayro Martina | — | New York Yankees | New York Yankees signed free agent RHP Sunayro Martina to a minor league contract. |
| Jul 13, 2022 | Signed as free agent | Kyle Tyler | — | San Francisco Giants | San Francisco Giants signed free agent RHP Kyle Tyler to a minor league contract. |
| Jul 12, 2022 | Signed as free agent | Colton Shaver | — | Toronto Blue Jays | Toronto Blue Jays signed free agent C Colton Shaver to a minor league contract. |
| Jul 12, 2022 | Signed as free agent | Ramon Moreno | — | Milwaukee Brewers | Milwaukee Brewers signed free agent CF Ramon Moreno to a minor league contract. |
| Jul 12, 2022 | Signed as free agent | Esmir Suarez | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Esmir Suarez to a minor league contract. |
| Jul 12, 2022 | Signed as free agent | Julio Garcia | — | Miami Marlins | Miami Marlins signed free agent RHP Julio Garcia to a minor league contract. |
| Jul 11, 2022 | Trade | CJ Alexander | Atlanta Braves | Kansas City Royals | Atlanta Braves traded OF Drew Waters, RHP Andrew Hoffmann and 3B CJ Alexander to Kansas City Royals for Draft Pick. CBA Pick # 35. |
| Jul 11, 2022 | Trade | Cody Sedlock | Baltimore Orioles | Detroit Tigers | Baltimore Orioles traded RHP Cody Sedlock to Detroit Tigers. |
| Jul 11, 2022 | Signed as free agent | Jean Correa | — | Cincinnati Reds | Cincinnati Reds signed free agent RHP Jean Correa to a minor league contract. |
| Jul 11, 2022 | Signed as free agent | Jose Varela | — | Houston Astros | Houston Astros signed free agent RHP Jose Varela to a minor league contract. |
| Jul 10, 2022 | Trade | Unnamed | Atlanta Braves | San Diego Padres | San Diego Padres traded 2B Robinson Cano to Atlanta Braves for cash. |
| Jul 10, 2022 | Signed as free agent | Bryan Chi | — | Texas Rangers | Texas Rangers signed free agent RHP Bryan Chi to a minor league contract. |
| Jul 9, 2022 | Released | Hansel Robles | — | Boston Red Sox | Boston Red Sox released RHP Hansel Robles. |
| Jul 9, 2022 | Trade | Cal Stevenson | Tampa Bay Rays | Athletics | Oakland Athletics traded C Christian Bethancourt to Tampa Bay Rays for OF Cal Stevenson and RHP Christian Fernandez. |
| Jul 9, 2022 | Released | Nick Wittgren | — | St. Louis Cardinals | St. Louis Cardinals released RHP Nick Wittgren. |
| Jul 9, 2022 | Signed as free agent | Ronnie Williams | — | San Francisco Giants | San Francisco Giants signed free agent RHP Ronnie Williams to a minor league contract. |
| Jul 8, 2022 | Trade | Yohan Ramírez | Cleveland Guardians | Pittsburgh Pirates | Cleveland Guardians traded RHP Yohan Ramirez to Pittsburgh Pirates. |
| Jul 8, 2022 | Released | Chasen Shreve | — | New York Mets | New York Mets released LHP Chasen Shreve. |
| Jul 8, 2022 | Signed as free agent | Luis Aparicio | — | Cleveland Guardians | Cleveland Guardians signed free agent OF Luis Aparicio to a minor league contract. |
| Jul 8, 2022 | Signed as free agent | Antonis Macias | — | Texas Rangers | Texas Rangers signed free agent OF Antonis Macias to a minor league contract. |
| Jul 8, 2022 | Signed as free agent | Jackson Grounds | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent RHP Jackson Grounds to a minor league contract. |
| Jul 8, 2022 | Signed as free agent | Luis Morellis | — | Cincinnati Reds | Cincinnati Reds signed free agent RHP Luis Morellis to a minor league contract. |
| Jul 8, 2022 | Signed as free agent | Jackson Grounds | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent RHP Jackson Grounds to a minor league contract. |
| Jul 7, 2022 | Trade | Tobias Myers | Cleveland Guardians | San Francisco Giants | Cleveland Guardians traded RHP Tobias Myers to San Francisco Giants. |
| Jul 7, 2022 | Signed as free agent | Brayan Rodriguez | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Brayan Rodriguez to a minor league contract. |
| Jul 7, 2022 | Signed as free agent | Nick Vincent | — | Detroit Tigers | Detroit Tigers signed free agent RHP Nick Vincent to a minor league contract. |
| Jul 7, 2022 | Signed as free agent | Fraudy Rodriguez | — | Detroit Tigers | Detroit Tigers signed free agent C Fraudy Rodriguez to a minor league contract. |
| Jul 6, 2022 | Signed as free agent | Blake Weiman | — | Seattle Mariners | Seattle Mariners signed free agent LHP Blake Weiman to a minor league contract. |
| Jul 6, 2022 | Signed as free agent | Ruben Garcia | — | Kansas City Royals | Kansas City Royals signed free agent RHP Ruben Garcia to a minor league contract. |
| Jul 6, 2022 | Trade | Jesús Liranzo | Arizona Diamondbacks | Detroit Tigers | Arizona Diamondbacks traded RHP Jesus Liranzo to Detroit Tigers for Future Considerations. |
| Jul 6, 2022 | Signed as free agent | Axel Hernandez | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Axel Hernandez to a minor league contract. |
| Jul 6, 2022 | Signed as free agent | Tim Fischer | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Tim Fischer to a minor league contract. |
| Jul 5, 2022 | Trade | Leonel Callez | Toronto Blue Jays | Atlanta Braves | Toronto Blue Jays traded 2B Leonel Callez to Atlanta Braves. |
| Jul 5, 2022 | Signed as free agent | Victor Diaz | — | Houston Astros | Houston Astros signed free agent C Victor Diaz to a minor league contract. |
| Jul 5, 2022 | Signed as free agent | Charbel Gonzalez | — | Chicago Cubs | Chicago Cubs signed free agent RHP Charbel Gonzalez to a minor league contract. |
| Jul 4, 2022 | Trade | Touki Toussaint | Atlanta Braves | Los Angeles Angels | Atlanta Braves traded RHP Touki Toussaint to Los Angeles Angels. |
| Jul 4, 2022 | Signed as free agent | James Dykstra | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RHP James Dykstra to a minor league contract. |
| Jul 4, 2022 | Signed as free agent | Geronimo Rombley | — | Baltimore Orioles | Baltimore Orioles signed free agent RHP Geronimo Rombley to a minor league contract. |
| Jul 4, 2022 | Signed as free agent | Hyungchan Um | — | Kansas City Royals | Kansas City Royals signed free agent C Hyungchan Um to a minor league contract. |
| Jul 4, 2022 | Signed as free agent | Hector Lantigua | — | Texas Rangers | Texas Rangers signed free agent SS Hector Lantigua to a minor league contract. |
| Jul 4, 2022 | Signed as free agent | Leandro Hernandez | — | Miami Marlins | Miami Marlins signed free agent RHP Leandro Hernandez to a minor league contract. |
| Jul 3, 2022 | Trade | Unnamed | Colorado Rockies | Philadelphia Phillies | Philadelphia Phillies traded RHP Corey Oswalt to Colorado Rockies for cash. |
| Jul 3, 2022 | Trade | Unnamed | Pittsburgh Pirates | New York Yankees | New York Yankees traded LHP Manny Banuelos to Pittsburgh Pirates for cash. |
| Jul 3, 2022 | Signed as free agent | Alix Hernandez | — | San Francisco Giants | San Francisco Giants signed free agent RHP Alix Hernandez to a minor league contract. |
| Jul 3, 2022 | Signed as free agent | Marco Corcho | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Marco Corcho to a minor league contract. |
| Jul 2, 2022 | Trade | Anthony Banda | Pittsburgh Pirates | Toronto Blue Jays | Pittsburgh Pirates traded LHP Anthony Banda to Toronto Blue Jays for cash. |
| Jul 2, 2022 | Signed as free agent | Jonathan Villar | — | Los Angeles Angels | Los Angeles Angels signed free agent SS Jonathan Villar. |
| Jul 2, 2022 | Signed as free agent | Duncan Snider | — | San Diego Padres | San Diego Padres signed free agent RHP Duncan Snider to a minor league contract. |
| Jul 2, 2022 | Signed as free agent | Jeison Sanchez | — | San Diego Padres | San Diego Padres signed free agent RHP Jeison Sanchez to a minor league contract. |
| Jul 2, 2022 | Signed as free agent | Abel Lorenzo | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent C Abel Lorenzo to a minor league contract. |
| Jul 2, 2022 | Signed as free agent | Franderly Morel | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent LHP Franderly Morel to a minor league contract. |
| Jul 2, 2022 | Signed as free agent | Jose Gonzalez | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent OF Jose Gonzalez to a minor league contract. |
| Jul 2, 2022 | Signed as free agent | Paris Johnson | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent OF Paris Johnson to a minor league contract. |
| Jul 2, 2022 | Signed as free agent | Jecsua Liborius | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Jecsua Liborius to a minor league contract. |
| Jul 2, 2022 | Signed as free agent | Jose Torrez | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent C Jose Torrez to a minor league contract. |
| Jul 2, 2022 | Signed as free agent | Rodmar Angela | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent OF Rodmar Angela to a minor league contract. |
| Jul 2, 2022 | Signed as free agent | Angel Cruz | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Angel Cruz to a minor league contract. |
| Jul 2, 2022 | Signed as free agent | Jeremy Castro | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Jeremy Castro to a minor league contract. |
| Jul 2, 2022 | Signed as free agent | Railin Familia | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent C Railin Familia to a minor league contract. |
| Jul 1, 2022 | Trade | Unnamed | Atlanta Braves | Boston Red Sox | Boston Red Sox traded RHP Silvino Bracho to Atlanta Braves for cash. |
| Jul 1, 2022 | Signed as free agent | Michael Boyle | — | Minnesota Twins | Minnesota Twins signed free agent LHP Michael Boyle to a minor league contract. |
| Jul 1, 2022 | Signed as free agent | Fraynel Nova | — | Kansas City Royals | Kansas City Royals signed free agent RHP Fraynel Nova to a minor league contract. |
| Jun 30, 2022 | Signed as free agent | AJ Graffanino | — | Philadelphia Phillies | Philadelphia Phillies signed free agent SS AJ Graffanino to a minor league contract. |
| Jun 30, 2022 | Signed as free agent | Heath Hembree | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Heath Hembree to a minor league contract. |
| Jun 29, 2022 | Signed as free agent | Sergio Romo | — | Toronto Blue Jays | Toronto Blue Jays signed free agent RHP Sergio Romo. |
| Jun 29, 2022 | Signed as free agent | Chris Roycroft | — | St. Louis Cardinals | St. Louis Cardinals signed free agent RHP Chris Roycroft to a minor league contract. |
| Jun 29, 2022 | Signed as free agent | Drew Hutchison | — | Detroit Tigers | Detroit Tigers signed free agent RHP Drew Hutchison to a minor league contract. |
| Jun 29, 2022 | Signed as free agent | Gregori Louis | — | New York Mets | New York Mets signed free agent LHP Gregori Louis to a minor league contract. |
| Jun 29, 2022 | Signed as free agent | Roel Ramírez | — | Atlanta Braves | Atlanta Braves signed free agent RHP Roel Ramirez. |
| Jun 28, 2022 | Trade | Sandy León | Cincinnati Reds | Cleveland Guardians | Cincinnati Reds traded C Sandy Leon to Cleveland Guardians. |
| Jun 28, 2022 | Released | Jonathan Villar | — | Chicago Cubs | Chicago Cubs released SS Jonathan Villar. |
| Jun 28, 2022 | Signed as free agent | Darwin De Leon | — | Houston Astros | Houston Astros signed free agent SS Darwin De Leon to a minor league contract. |
| Jun 28, 2022 | Signed as free agent | Christopher Consoro | — | Cincinnati Reds | Cincinnati Reds signed free agent IF Christopher Consoro to a minor league contract. |
| Jun 27, 2022 | Trade | Carlos Santana | Kansas City Royals | Seattle Mariners | Seattle Mariners traded RHP Wyatt Mills and RHP William Fleming to Kansas City Royals for 1B Carlos Santana and cash. |
| Jun 27, 2022 | Signed as free agent | Rodney Hutchison | — | Seattle Mariners | Seattle Mariners signed free agent RHP Rodney Hutchison to a minor league contract. |
| Jun 27, 2022 | Signed as free agent | Chris Mazza | — | Seattle Mariners | Seattle Mariners signed free agent RHP Chris Mazza to a minor league contract. |
| Jun 27, 2022 | Signed as free agent | Geral Gonzales | — | San Diego Padres | San Diego Padres signed free agent RHP Geral Gonzales to a minor league contract. |
| Jun 27, 2022 | Signed as free agent | Halan Dishmey | — | Chicago White Sox | Chicago White Sox signed free agent RHP Halan Dishmey to a minor league contract. |
| Jun 27, 2022 | Signed as free agent | Edgar Gamargo | — | Cleveland Guardians | Cleveland Guardians signed free agent C Edgar Gamargo to a minor league contract. |
| Jun 27, 2022 | Signed as free agent | Joel Hurtado | — | Los Angeles Angels | Los Angeles Angels signed free agent RHP Joel Hurtado to a minor league contract. |
| Jun 27, 2022 | Signed as free agent | Brennan Bernardino | — | Seattle Mariners | Seattle Mariners signed free agent LHP Brennan Bernardino to a minor league contract. |
| Jun 26, 2022 | Signed as free agent | Jace Fry | — | Philadelphia Phillies | Philadelphia Phillies signed free agent LHP Jace Fry to a minor league contract. |
| Jun 26, 2022 | Released | Heath Hembree | — | Pittsburgh Pirates | Pittsburgh Pirates released RHP Heath Hembree. |
| Jun 25, 2022 | Trade | Trey Amburgey | Cincinnati Reds | Seattle Mariners | Cincinnati Reds traded LF Trey Amburgey to Seattle Mariners. |
| Jun 25, 2022 | Signed as free agent | Deven Marrero | — | New York Mets | New York Mets signed free agent 3B Deven Marrero to a minor league contract. |
| Jun 25, 2022 | Signed as free agent | Brayan Suarez | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Brayan Suarez to a minor league contract. |
| Jun 24, 2022 | Signed as free agent | Andy Atwood | — | Chicago White Sox | Chicago White Sox signed free agent 2B Andy Atwood to a minor league contract. |
| Jun 24, 2022 | Signed as free agent | Michael Krauza | — | New York Mets | New York Mets signed free agent RHP Michael Krauza to a minor league contract. |
| Jun 24, 2022 | Signed as free agent | Jose Robledo | — | Houston Astros | Houston Astros signed free agent SS Jose Robledo to a minor league contract. |
| Jun 24, 2022 | Signed as free agent | Francisco Mercado | — | New York Mets | New York Mets signed free agent RHP Franciso Mercado to a minor league contract. |
| Jun 23, 2022 | Signed as free agent | Greyber Altamirano | — | Miami Marlins | Miami Marlins signed free agent Greyber Altamirano to a minor league contract. |
| Jun 23, 2022 | Signed as free agent | Cristofer Gomez | — | New York Mets | New York Mets signed free agent RHP Cristofer Gomez to a minor league contract. |
| Jun 23, 2022 | Trade | David McKay | New York Yankees | Tampa Bay Rays | New York Yankees traded RHP David McKay to Tampa Bay Rays. |
| Jun 23, 2022 | Trade | Unnamed | Milwaukee Brewers | Baltimore Orioles | Baltimore Orioles traded 2B Patrick Dorrian to Milwaukee Brewers for cash. |
| Jun 23, 2022 | Signed as free agent | Billy Hamilton | — | Miami Marlins | Miami Marlins signed free agent CF Billy Hamilton to a minor league contract. |
| Jun 23, 2022 | Trade | Ryan Lavarnway | Detroit Tigers | Miami Marlins | Detroit Tigers traded C Ryan Lavarnway to Miami Marlins. |
| Jun 23, 2022 | Signed as free agent | Shane Gustafson | — | Cincinnati Reds | Cincinnati Reds signed free agent RHP Shane Gustafson to a minor league contract. |
| Jun 23, 2022 | Signed as free agent | Edmundo Rodriguez | — | Cincinnati Reds | Cincinnati Reds signed free agent LHP Edmundo Rodriguez to a minor league contract. |
| Jun 23, 2022 | Signed as free agent | Michael Campusano | — | New York Mets | New York Mets signed free agent OF Michael Campusano to a minor league contract. |
| Jun 22, 2022 | Signed as free agent | John Nogowski | — | Washington Nationals | Washington Nationals signed free agent 1B John Nogowski to a minor league contract. |
| Jun 22, 2022 | Signed as free agent | Jacob Barnes | — | Seattle Mariners | Seattle Mariners signed free agent RHP Jacob Barnes to a minor league contract. |
| Jun 22, 2022 | Signed as free agent | Ryan Weber | — | New York Yankees | New York Yankees signed free agent RHP Ryan Weber to a minor league contract. |
| Jun 22, 2022 | Signed as free agent | Marcus Walden | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Marcus Walden to a minor league contract. |
| Jun 22, 2022 | Signed as free agent | Jose Linares | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Jose Linares to a minor league contract. |
| Jun 22, 2022 | Signed as free agent | Jesus Camejo | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Jesus Camejo to a minor league contract. |
| Jun 21, 2022 | Trade | Eric Stout | Chicago Cubs | Pittsburgh Pirates | Chicago Cubs traded LHP Eric Stout to Pittsburgh Pirates for cash. |
| Jun 21, 2022 | Released | Joey Gerber | — | Seattle Mariners | Seattle Mariners released RHP Joey Gerber. |
| Jun 21, 2022 | Released | Sergio Romo | — | Seattle Mariners | Seattle Mariners released RHP Sergio Romo. |
| Jun 21, 2022 | Released | Lorenzo Cain | — | Milwaukee Brewers | Milwaukee Brewers released CF Lorenzo Cain. |
| Jun 21, 2022 | Signed as free agent | Erick Rodriguez | — | Seattle Mariners | Seattle Mariners signed free agent RHP Erick Rodriguez to a minor league contract. |
| Jun 21, 2022 | Signed as free agent | Richard Rodríguez | — | New York Yankees | New York Yankees signed free agent RHP Richard Rodriguez to a minor league contract. |
| Jun 20, 2022 | Signed as free agent | Unnamed | — | New York Mets | New York Mets signed free agent C Ruben Yustiz to a minor league contract. |
| Jun 20, 2022 | Signed as free agent | Ilmerson Colon | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent LHP Ilmerson Colon to a minor league contract. |
| Jun 20, 2022 | Signed as free agent | Serafino Brito | — | Athletics | Oakland Athletics signed free agent RHP Serafino Brito to a minor league contract. |
| Jun 20, 2022 | Trade | Unnamed | — | Los Angeles Dodgers | Detroit Tigers traded RF Trayce Thompson and to Los Angeles Dodgers for cash. |
| Jun 20, 2022 | Signed as free agent | Billy Hamilton | — | Miami Marlins | Miami Marlins signed free agent CF Billy Hamilton to a minor league contract. |
| Jun 20, 2022 | Signed as free agent | Anthony Garcia | — | Atlanta Braves | Atlanta Braves signed free agent RHP Anthony Garcia to a minor league contract. |
| Jun 19, 2022 | Released | Dee Strange-Gordon | — | Washington Nationals | Washington Nationals released 2B Dee Strange-Gordon. |
| Jun 18, 2022 | Signed as free agent | Chris Owings | — | New York Yankees | New York Yankees signed free agent SS Chris Owings to a minor league contract. |
| Jun 18, 2022 | Signed as free agent | Braden Bishop | — | Minnesota Twins | Minnesota Twins signed free agent CF Braden Bishop to a minor league contract. |
| Jun 18, 2022 | Trade | Unnamed | Boston Red Sox | Philadelphia Phillies | Philadelphia Phillies traded RHP James Norwood to Boston Red Sox for cash. |
| Jun 18, 2022 | Released | Jacob Barnes | — | Detroit Tigers | Detroit Tigers released RHP Jacob Barnes. |
| Jun 18, 2022 | Signed as free agent | Michael Reed | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent CF Buddy Reed to a minor league contract. |
| Jun 18, 2022 | Signed as free agent | Unnamed | — | New York Mets | New York Mets signed free agent RHP Cristofer Gomez to a minor league contract. |
| Jun 18, 2022 | Signed as free agent | Gabriel Estrada | — | Washington Nationals | Washington Nationals signed free agent RHP Gabriel Estrada to a minor league contract. |
| Jun 17, 2022 | Signed as free agent | Matt Hall | — | San Francisco Giants | San Francisco Giants signed free agent LHP Matt Hall to a minor league contract. |
| Jun 17, 2022 | Signed as free agent | Miguelangel Rodriguez | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RHP Miguelangel Rodriguez to a minor league contract. |
| Jun 16, 2022 | Signed as free agent | Dan Winkler | — | Chicago White Sox | Chicago White Sox signed free agent RHP Dan Winkler to a minor league contract. |
| Jun 16, 2022 | Signed as free agent | Angel Feliz | — | Colorado Rockies | Colorado Rockies signed free agent OF Angel Feliz to a minor league contract. |
| Jun 16, 2022 | Signed as free agent | Fox Semones | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent 2B Fox Semones to a minor league contract. |
| Jun 16, 2022 | Signed as free agent | Jakob Goldfarb | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent C Jakob Goldfarb to a minor league contract. |
| Jun 16, 2022 | Signed as free agent | Juan Arias | — | San Diego Padres | San Diego Padres signed free agent RHP Juan Arias to a minor league contract. |
| Jun 16, 2022 | Signed as free agent | Aneudis Mejia | — | Texas Rangers | Texas Rangers signed free agent RHP Aneudis Mejia to a minor league contract. |
| Jun 15, 2022 | Signed as free agent | Gary Mattis | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent SS Gary Mattis to a minor league contract. |
| Jun 15, 2022 | Signed as free agent | Gunnar Groen | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Gunnar Groen to a minor league contract. |
| Jun 15, 2022 | Signed as free agent | Yhonkervix Castillo | — | Los Angeles Angels | Los Angeles Angels signed free agent LHP Yhonkervix Castillo to a minor league contract. |
| Jun 14, 2022 | Signed as free agent | Ryan Middendorf | — | Milwaukee Brewers | Milwaukee Brewers signed free agent LHP Ryan Middendorf to a minor league contract. |
| Jun 14, 2022 | Signed as free agent | Cruzmel Arias | — | Colorado Rockies | Colorado Rockies signed free agent C Cruzmel Arias to a minor league contract. |
| Jun 14, 2022 | Signed as free agent | Andrew Moore | — | Toronto Blue Jays | Toronto Blue Jays signed free agent RHP Andrew Moore to a minor league contract. |
| Jun 14, 2022 | Signed as free agent | Fran Visamon | — | Seattle Mariners | Seattle Mariners signed free agent RHP Fran Visamon to a minor league contract. |
| Jun 14, 2022 | Signed as free agent | Leodarlyn Colon | — | Washington Nationals | Washington Nationals signed free agent RHP Leodarlyn Colon to a minor league contract. |
| Jun 13, 2022 | Released | Ryan Burr | — | Chicago White Sox | Chicago White Sox released RHP Ryan Burr. |
| Jun 13, 2022 | Signed as free agent | Eddy Alberto | — | Baltimore Orioles | Baltimore Orioles signed free agent RHP Eddy Alberto to a minor league contract. |
| Jun 12, 2022 | Signed as free agent | Tim Holdgrafer | — | Kansas City Royals | Kansas City Royals signed free agent RHP Tim Holdgrafer to a minor league contract. |
| Jun 12, 2022 | Released | Chris Owings | — | Baltimore Orioles | Baltimore Orioles released SS Chris Owings. |
| Jun 11, 2022 | Trade | Michael Mariot | Philadelphia Phillies | Detroit Tigers | Philadelphia Phillies traded RHP Michael Mariot to Detroit Tigers. |
| Jun 11, 2022 | Signed as free agent | Chris Givin | — | Baltimore Orioles | Baltimore Orioles signed free agent SS Chris Givin to a minor league contract. |
| Jun 11, 2022 | Signed as free agent | Enmanuel Martinez | — | Boston Red Sox | Boston Red Sox signed free agent C Enmanuel Martinez to a minor league contract. |
| Jun 11, 2022 | Signed as free agent | Elvis Soto | — | Boston Red Sox | Boston Red Sox signed free agent RHP Elvis Soto to a minor league contract. |
| Jun 10, 2022 | Signed as free agent | Zach Huffins | — | Minnesota Twins | Minnesota Twins signed free agent CF Zach Huffins to a minor league contract. |
| Jun 10, 2022 | Signed as free agent | Leonel Ferrand | — | Kansas City Royals | Kansas City Royals signed free agent LHP Leonel Ferrand to a minor league contract. |
| Jun 10, 2022 | Signed as free agent | Engel Peralta | — | Houston Astros | Houston Astros signed free agent RHP Engel Daniel Peralta to a minor league contract. |
| Jun 10, 2022 | Signed as free agent | Jose Serrano | — | Houston Astros | Houston Astros signed free agent RHP Jose Serrano to a minor league contract. |
| Jun 10, 2022 | Signed as free agent | Anthony Cruz | — | Houston Astros | Houston Astros signed free agent RHP Anthony Cruz to a minor league contract. |
| Jun 10, 2022 | Signed as free agent | Unnamed | — | Houston Astros | Houston Astros signed free agent RHP Jose Serrano to a minor league contract. |
| Jun 9, 2022 | Signed as free agent | Johan Palacios | — | Miami Marlins | Miami Marlins signed free agent Joahn Palacios to a minor league contract. |
| Jun 9, 2022 | Signed as free agent | Unnamed | — | New York Yankees | New York Yankees signed free agent Johan Ferreira to a minor league contract. |
| Jun 9, 2022 | Signed as free agent | Juan Rodriguez | — | Miami Marlins | Miami Marlins signed free agent C Juan Rodriguez to a minor league contract. |
| Jun 9, 2022 | Signed as free agent | Julio Ramirez | — | Toronto Blue Jays | Toronto Blue Jays signed free agent Julio Ramirez to a minor league contract. |
| Jun 9, 2022 | Signed as free agent | Unnamed | — | New York Mets | New York Mets signed free agent RHP Wilson Lopez to a minor league contract. |
| Jun 9, 2022 | Signed as free agent | Unnamed | — | Colorado Rockies | Colorado Rockies signed free agent Enmanuel Pio to a minor league contract. |
| Jun 9, 2022 | Signed as free agent | Unnamed | — | Texas Rangers | Texas Rangers signed free agent RHP Dianyer Florentino to a minor league contract. |
| Jun 9, 2022 | Signed as free agent | Unnamed | — | New York Yankees | New York Yankees signed free agent Carlos Herrara to a minor league contract. |
| Jun 9, 2022 | Signed as free agent | Hunter Dollander | — | Chicago White Sox | Chicago White Sox signed free agent RHP Hunter Dollander to a minor league contract. |
| Jun 9, 2022 | Signed as free agent | Jeremy Castro | — | Kansas City Royals | Kansas City Royals signed free agent RHP Jeremy Castro to a minor league contract. |
| Jun 9, 2022 | Signed as free agent | Jose Brito | — | Minnesota Twins | Minnesota Twins signed free agent RHP Jose Brito to a minor league contract. |
| Jun 9, 2022 | Signed as free agent | Kyle Zurak | — | Detroit Tigers | Detroit Tigers signed free agent RHP Kyle Zurak to a minor league contract. |
| Jun 8, 2022 | Trade | Michael Plassmeyer | San Francisco Giants | Philadelphia Phillies | San Francisco Giants traded LHP Michael Plassmeyer and cash to Philadelphia Phillies for C Austin Wynns. |
| Jun 8, 2022 | Signed as free agent | Kyle Martin | — | San Diego Padres | San Diego Padres signed free agent 1B Kyle Martin to a minor league contract. |
| Jun 8, 2022 | Signed as free agent | Nick Gallagher | — | Chicago White Sox | Chicago White Sox signed free agent RHP Nick Gallagher to a minor league contract. |
| Jun 8, 2022 | Signed as free agent | Skylar Arias | — | Chicago White Sox | Chicago White Sox signed free agent LHP Skylar Arias to a minor league contract. |
| Jun 8, 2022 | Released | Gabe Klobosits | — | Athletics | Oakland Athletics released RHP Gabe Klobosits. |
| Jun 8, 2022 | Signed as free agent | Shelby Miller | — | San Francisco Giants | San Francisco Giants signed free agent RHP Shelby Miller to a minor league contract. |
| Jun 8, 2022 | Signed as free agent | Jean Carmona | — | Milwaukee Brewers | Milwaukee Brewers signed free agent SS Jean Carmona to a minor league contract. |
| Jun 8, 2022 | Signed as free agent | Christopher Medina | — | New York Yankees | New York Yankees signed free agent RHP Christopher Medina to a minor league contract. |
| Jun 8, 2022 | Signed as free agent | Rodrigo Vigil | — | Seattle Mariners | Seattle Mariners signed free agent C Rodrigo Vigil to a minor league contract. |
| Jun 8, 2022 | Signed as free agent | Eduardo Tovar | — | Seattle Mariners | Seattle Mariners signed free agent RHP Eduardo Tovar to a minor league contract. |
| Jun 8, 2022 | Signed as free agent | Dervy Ventura | — | Seattle Mariners | Seattle Mariners signed free agent SS Dervy Ventura to a minor league contract. |
| Jun 8, 2022 | Signed as free agent | Ofelky Peralta | — | San Francisco Giants | San Francisco Giants signed free agent RHP Ofelky Peralta to a minor league contract. |
| Jun 8, 2022 | Signed as free agent | Jesus Mosquera | — | Texas Rangers | Texas Rangers signed free agent RHP Jesus Mosquera to a minor league contract. |
| Jun 8, 2022 | Signed as free agent | Abiatal Avelino | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent SS Abiatal Avelino to a minor league contract. |
| Jun 8, 2022 | Signed as free agent | Cesar D'Oleo | — | Chicago White Sox | Chicago White Sox signed free agent OF Cesar D'Oleo to a minor league contract. |
| Jun 8, 2022 | Signed as free agent | Keegan Curtis | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Keegan Curtis to a minor league contract. |
| Jun 7, 2022 | Signed as free agent | Dallas Keuchel | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent LHP Dallas Keuchel to a minor league contract. |
| Jun 7, 2022 | Trade | Jacob Webb | Arizona Diamondbacks | Atlanta Braves | Arizona Diamondbacks traded RHP Jacob Webb to Atlanta Braves. |
| Jun 7, 2022 | Signed as free agent | Grant Dayton | — | Los Angeles Angels | Los Angeles Angels signed free agent LHP Grant Dayton to a minor league contract. |
| Jun 7, 2022 | Signed as free agent | Erick Bautista | — | Colorado Rockies | Colorado Rockies signed free agent OF Erick Bautista to a minor league contract. |
| Jun 7, 2022 | Signed as free agent | Cesar Espinal | — | Baltimore Orioles | Baltimore Orioles signed free agent RHP Cesar Espinal to a minor league contract. |
| Jun 7, 2022 | Signed as free agent | Terrance Gore | — | New York Mets | New York Mets signed free agent LF Terrance Gore to a minor league contract. |
| Jun 7, 2022 | Signed as free agent | Yordi Martinez | — | Toronto Blue Jays | Toronto Blue Jays signed free agent RHP Yordi Martinez to a minor league contract. |
| Jun 7, 2022 | Signed as free agent | Jose Figueroa | — | Toronto Blue Jays | Toronto Blue Jays signed free agent RHP Jose Figueroa to a minor league contract. |
| Jun 7, 2022 | Signed as free agent | Juan Nunez | — | Houston Astros | Houston Astros signed free agent RHP Juan Nunez to a minor league contract. |
| Jun 7, 2022 | Signed as free agent | Yeimison Arias | — | Texas Rangers | Texas Rangers signed free agent RHP Yeimison Arias to a minor league contract. |
| Jun 7, 2022 | Signed as free agent | Jonh Henriquez | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RHP Jonh Henriquez to a minor league contract. |
| Jun 7, 2022 | Signed as free agent | David Davalillo | — | Texas Rangers | Texas Rangers signed free agent RHP David Davalillo to a minor league contract. |
| Jun 6, 2022 | Signed as free agent | Pierce Banks | — | Minnesota Twins | Minnesota Twins signed free agent RHP Pierce Banks to a minor league contract. |
| Jun 6, 2022 | Signed as free agent | Aaron Sanchez | — | Minnesota Twins | Minnesota Twins signed free agent RHP Aaron Sanchez to a minor league contract. |
| Jun 6, 2022 | Trade | Ike Freeman | Cleveland Guardians | San Diego Padres | Cleveland Guardians traded SS Ike Freeman to San Diego Padres. |
| Jun 6, 2022 | Trade | Dawson Dimon | Tampa Bay Rays | Atlanta Braves | Tampa Bay Rays traded C Dawson Dimon to Atlanta Braves. |
| Jun 6, 2022 | Signed as free agent | Liam Jenkins | — | Chicago White Sox | Chicago White Sox signed free agent RHP Liam Jenkins to a minor league contract. |
| Jun 6, 2022 | Signed as free agent | Coleton Horner | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent C Coleton Horner to a minor league contract. |
| Jun 6, 2022 | Signed as free agent | Yensy Bello | — | Seattle Mariners | Seattle Mariners signed free agent IF Yensy Bello to a minor league contract. |
| Jun 6, 2022 | Signed as free agent | Carter Raffield | — | Cincinnati Reds | Cincinnati Reds signed free agent RHP Carter Raffield to a minor league contract. |
| Jun 6, 2022 | Signed as free agent | Cole Ayers | — | New York Yankees | New York Yankees signed free agent RHP Cole Ayers to a minor league contract. |
| Jun 6, 2022 | Signed as free agent | Daniel Guerra | — | Toronto Blue Jays | Toronto Blue Jays signed free agent RHP Daniel Guerra to a minor league contract. |
| Jun 6, 2022 | Signed as free agent | Gregori Ramirez | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Gregori Ramirez to a minor league contract. |
| Jun 5, 2022 | Trade | Ryan Borucki | Toronto Blue Jays | Seattle Mariners | Toronto Blue Jays traded LHP Ryan Borucki to Seattle Mariners for 3B Tyler Keenan. |
| Jun 5, 2022 | Signed as free agent | Mike Wright Jr. | — | Chicago White Sox | Chicago White Sox signed free agent RHP Mike Wright Jr. to a minor league contract. |
| Jun 5, 2022 | Signed as free agent | Justin King | — | Milwaukee Brewers | Milwaukee Brewers signed free agent LHP Justin King to a minor league contract. |
| Jun 5, 2022 | Signed as free agent | Cristian Sierra | — | Miami Marlins | Miami Marlins signed free agent RHP Cristian Sierra to a minor league contract. |
| Jun 4, 2022 | Signed as free agent | Loidel Chapelli | — | Chicago White Sox | Chicago White Sox signed free agent OF Loidel Chapelli to a minor league contract. |
| Jun 4, 2022 | Signed as free agent | Nicolas Uriepero | — | Miami Marlins | Miami Marlins signed free agent RHP Nicolas Uriepero to a minor league contract. |
| Jun 4, 2022 | Signed as free agent | Anthony Flores | — | Milwaukee Brewers | Milwaukee Brewers signed free agent LHP Anthony Flores to a minor league contract. |
| Jun 4, 2022 | Signed as free agent | Jose Meneses | — | Milwaukee Brewers | Milwaukee Brewers signed free agent LHP Jose Meneses to a minor league contract. |
| Jun 4, 2022 | Signed as free agent | Daurys Mora | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Daurys Mora to a minor league contract. |
| Jun 4, 2022 | Signed as free agent | Reybert Reyes | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Reybert Reyes to a minor league contract. |
| Jun 4, 2022 | Signed as free agent | Jeral Vizcaino | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Jeral Vizcaino to a minor league contract. |
| Jun 4, 2022 | Signed as free agent | Edwin Tamoy | — | Milwaukee Brewers | Milwaukee Brewers signed free agent C Edwin Tamoy to a minor league contract. |
| Jun 4, 2022 | Signed as free agent | Ludwin Tejada | — | Milwaukee Brewers | Milwaukee Brewers signed free agent C Ludwin Tejada to a minor league contract. |
| Jun 4, 2022 | Signed as free agent | Francisco Nina | — | Milwaukee Brewers | Milwaukee Brewers signed free agent OF Francisco Nina to a minor league contract. |
| Jun 4, 2022 | Signed as free agent | Juan Baez | — | Milwaukee Brewers | Milwaukee Brewers signed free agent C Juan Baez to a minor league contract. |
| Jun 4, 2022 | Signed as free agent | Edgardo Reyes | — | Milwaukee Brewers | Milwaukee Brewers signed free agent 3B Edgardo Reyes to a minor league contract. |
| Jun 4, 2022 | Signed as free agent | Donis Rodriguez | — | Milwaukee Brewers | Milwaukee Brewers signed free agent SS Donis Rodriguez to a minor league contract. |
| Jun 4, 2022 | Signed as free agent | Colby Morris | — | Seattle Mariners | Seattle Mariners signed free agent RHP Colby Morris to a minor league contract. |
| Jun 4, 2022 | Trade | Juan Zabala | Los Angeles Dodgers | San Diego Padres | Los Angeles Dodgers traded C Juan Zabala to San Diego Padres. |
| Jun 4, 2022 | Signed as free agent | David Landeta | — | Houston Astros | Houston Astros signed free agent RHP David Landeta to a minor league contract. |
| Jun 3, 2022 | Trade | Albert Abreu | Texas Rangers | Kansas City Royals | Kansas City Royals traded RHP Yohanse Morel to Texas Rangers for RHP Albert Abreu. |
| Jun 3, 2022 | Released | Jahmai Jones | — | Baltimore Orioles | Baltimore Orioles released CF Jahmai Jones. |
| Jun 3, 2022 | Signed as free agent | Tyler Thornburg | — | Minnesota Twins | Minnesota Twins signed free agent RHP Tyler Thornburg to a minor league contract. |
| Jun 3, 2022 | Trade | Unnamed | New York Yankees | Cincinnati Reds | Cincinnati Reds traded DH Jake Bauers to New York Yankees for cash. |
| Jun 3, 2022 | Signed as free agent | Luis Tejeda | — | Kansas City Royals | Kansas City Royals signed free agent OF Luis Tejeda to a minor league contract. |
| Jun 3, 2022 | Signed as free agent | Emmanuel Reyes | — | Kansas City Royals | Kansas City Royals signed free agent RHP Emmanuel Reyes to a minor league contract. |
| Jun 3, 2022 | Signed as free agent | Angel Hernandez | — | Miami Marlins | Miami Marlins signed free agent RHP Angel Hernandez to a minor league contract. |
| Jun 3, 2022 | Signed as free agent | Roman La Torre | — | Milwaukee Brewers | Milwaukee Brewers signed free agent C Roman La Torre to a minor league contract. |
| Jun 3, 2022 | Signed as free agent | Deylin Gomez | — | Milwaukee Brewers | Milwaukee Brewers signed free agent 1B Deylin Gomez to a minor league contract. |
| Jun 3, 2022 | Signed as free agent | Luis Lara | — | Milwaukee Brewers | Milwaukee Brewers signed free agent CF Luis Lara to a minor league contract. |
| Jun 3, 2022 | Signed as free agent | Fabricio Valera | — | Milwaukee Brewers | Milwaukee Brewers signed free agent LF Fabricio Valera to a minor league contract. |
| Jun 3, 2022 | Signed as free agent | Gery Holguin | — | Milwaukee Brewers | Milwaukee Brewers signed free agent SS Gery Holguin to a minor league contract. |
| Jun 3, 2022 | Signed as free agent | Angel Pereira | — | Milwaukee Brewers | Milwaukee Brewers signed free agent SS Angel Pereira to a minor league contract. |
| Jun 3, 2022 | Signed as free agent | Jose Pena | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Jose Pena to a minor league contract. |
| Jun 3, 2022 | Signed as free agent | Royer Cabrera | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Royer Cabrera to a minor league contract. |
| Jun 3, 2022 | Signed as free agent | Justin Caceres | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Justin Caceres to a minor league contract. |
| Jun 3, 2022 | Signed as free agent | Jhofez Mejias | — | Milwaukee Brewers | Milwaukee Brewers signed free agent LHP Jhofez Mejias to a minor league contract. |
| Jun 3, 2022 | Signed as free agent | Osbriel Mogollon | — | Milwaukee Brewers | Milwaukee Brewers signed free agent LHP Osbriel Mogollon to a minor league contract. |
| Jun 3, 2022 | Signed as free agent | Bryan Rivera | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Bryan Rivera to a minor league contract. |
| Jun 3, 2022 | Signed as free agent | Ranwell Smith | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Ranwell Smith to a minor league contract. |
| Jun 3, 2022 | Signed as free agent | Breijher Subero | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Breijher Subero to a minor league contract. |
| Jun 3, 2022 | Signed as free agent | Wande Torres | — | Milwaukee Brewers | Milwaukee Brewers signed free agent LHP Wande Torres to a minor league contract. |
| Jun 3, 2022 | Signed as free agent | Felipe De Los Santos | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Felipe De Los Santos to a minor league contract. |
| Jun 3, 2022 | Signed as free agent | Agustin Herrera | — | Kansas City Royals | Kansas City Royals signed free agent LHP Agustin Herrera to a minor league contract. |
| Jun 3, 2022 | Signed as free agent | Abel Moya | — | Chicago Cubs | Chicago Cubs signed free agent RHP Abel Moya to a minor league contract. |
| Jun 3, 2022 | Signed as free agent | Fraimin Marte | — | Chicago Cubs | Chicago Cubs signed free agent RHP Fraimin Marte to a minor league contract. |
| Jun 3, 2022 | Signed as free agent | Stanley Guzman | — | Chicago Cubs | Chicago Cubs signed free agent RHP Stanley Guzman to a minor league contract. |
| Jun 3, 2022 | Signed as free agent | Elvin Jimenez | — | Miami Marlins | Miami Marlins signed free agent RHP Elvin Jimenez to a minor league contract. |
| Jun 3, 2022 | Signed as free agent | Algeni Mejia | — | Cleveland Guardians | Cleveland Guardians signed free agent LHP Algeni Mejia to a minor league contract. |
| Jun 2, 2022 | Signed as free agent | Rancel Duarte | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Rancel Duarte to a minor league contract. |
| Jun 2, 2022 | Signed as free agent | Diovel Mariano | — | Cleveland Guardians | Cleveland Guardians signed free agent RHP Diovel Mariano to a minor league contract. |
| Jun 2, 2022 | Signed as free agent | Juan Sosa | — | Cleveland Guardians | Cleveland Guardians signed free agent LHP Juan Sosa to a minor league contract. |
| Jun 2, 2022 | Signed as free agent | Julio Zapata | — | Cleveland Guardians | Cleveland Guardians signed free agent RHP Julio Zapata to a minor league contract. |
| Jun 2, 2022 | Signed as free agent | Moises Brito | — | Toronto Blue Jays | Toronto Blue Jays signed free agent LHP Moises Brito to a minor league contract. |
| Jun 2, 2022 | Signed as free agent | Jose Ojo | — | Minnesota Twins | Minnesota Twins signed free agent RHP Jose Ojo to a minor league contract. |
| Jun 2, 2022 | Signed as free agent | Daniel Pena | — | Minnesota Twins | Minnesota Twins signed free agent C Daniel Pena to a minor league contract. |
| Jun 2, 2022 | Signed as free agent | Ronal Herrera | — | Baltimore Orioles | Baltimore Orioles signed free agent RHP Ronal Herrera to a minor league contract. |
| Jun 2, 2022 | Signed as free agent | Juan Peña | — | Baltimore Orioles | Baltimore Orioles signed free agent RHP Juan Pena to a minor league contract. |
| Jun 2, 2022 | Signed as free agent | Josi Novas | — | Kansas City Royals | Kansas City Royals signed free agent SS Josi Novas to a minor league contract. |
| Jun 2, 2022 | Signed as free agent | Angel Pierre | — | Kansas City Royals | Kansas City Royals signed free agent 3B Angel Pierre to a minor league contract. |
| Jun 2, 2022 | Signed as free agent | Yunior Marte | — | Kansas City Royals | Kansas City Royals signed free agent RHP Yunior Marte to a minor league contract. |
| Jun 2, 2022 | Signed as free agent | Brady Smith | — | New York Mets | New York Mets signed free agent C Brady Smith to a minor league contract. |
| Jun 2, 2022 | Signed as free agent | Jake Miednik | — | Seattle Mariners | Seattle Mariners signed free agent LHP Jake Miednik to a minor league contract. |
| Jun 2, 2022 | Signed as free agent | Juan Murillo | — | San Diego Padres | San Diego Padres signed free agent 3B Juan Murillo to a minor league contract. |
| Jun 2, 2022 | Signed as free agent | Jarrod Watkins | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent 2B Jarrod Watkins to a minor league contract. |
| Jun 2, 2022 | Signed as free agent | Jonaiker Castellar | — | Houston Astros | Houston Astros signed free agent RHP Jonaiker Castellar to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Bryant Landaeta | — | Detroit Tigers | Detroit Tigers signed free agent RHP Bryant Landaeta to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Alejandro Mateo | — | Chicago White Sox | Chicago White Sox signed free agent RHP Alejandro Mateo to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Elías Moscoso | — | Baltimore Orioles | Baltimore Orioles signed free agent RHP Elias Moscoso to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Wander Severino | — | Houston Astros | Houston Astros signed free agent RHP Wander Severino to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Karniel Pratt | — | Houston Astros | Houston Astros signed free agent OF Karniel Pratt to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Derek Corro | — | Athletics | Oakland Athletics signed free agent LHP Derek Corro to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Manuel Figuereo | — | Athletics | Oakland Athletics signed free agent RHP Manuel Figuereo to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Jefferson Jean | — | Athletics | Oakland Athletics signed free agent RHP Jeferson Jean to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Manuel Perez | — | Athletics | Oakland Athletics signed free agent RHP Manuel Perez to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Reynaldo Saa | — | Athletics | Oakland Athletics signed free agent RHP Reynaldo Saa to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Gerard Veloz | — | Athletics | Oakland Athletics signed free agent P Gerald Veloz to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Cesar Gonzalez | — | Athletics | Oakland Athletics signed free agent C Cesar Gonzalez to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Bryan Andrade | — | Athletics | Oakland Athletics signed free agent SS Bryan Andrade to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Kevin Dume | — | Athletics | Oakland Athletics signed free agent 1B Kevin Dume to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Jesus Franco | — | Kansas City Royals | Kansas City Royals signed free agent LHP Jesus Franco to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Wermer Pineda | — | Kansas City Royals | Kansas City Royals signed free agent RHP Wermer Pineda to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Juan Ozuna | — | Kansas City Royals | Kansas City Royals signed free agent LHP Juan Ozuna to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Junior Sanchez | — | Kansas City Royals | Kansas City Royals signed free agent RHP Junior Sanchez to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Juan Olmos | — | Kansas City Royals | Kansas City Royals signed free agent C Juan Olmos to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Andy Basora | — | Kansas City Royals | Kansas City Royals signed free agent RHP Andy Basora to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Jose Gutierrez | — | Kansas City Royals | Kansas City Royals signed free agent RHP Jose Gutierrez to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Yimi Presinal | — | Kansas City Royals | Kansas City Royals signed free agent RHP Yimi Presinal to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Ivan Sosa | — | Kansas City Royals | Kansas City Royals signed free agent SS Ivan Sosa to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Raimel Medina | — | Kansas City Royals | Kansas City Royals signed free agent OF Raimel Medina to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Henry Ramos | — | Kansas City Royals | Kansas City Royals signed free agent OF Henry Ramos to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Erick Torres | — | Kansas City Royals | Kansas City Royals signed free agent OF Erick Torres to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Estarlin Escalante | — | New York Mets | New York Mets signed free agent RHP Estarlin Escalante to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Maykel Minoso | — | Toronto Blue Jays | Toronto Blue Jays signed free agent C Maykel Minoso to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Jose Fernandez | — | Toronto Blue Jays | Toronto Blue Jays signed free agent SS Jose Fernandez to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Jeremy Gonzalez | — | Chicago White Sox | Chicago White Sox signed free agent LHP Jeremy Gonzalez to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Jesus Mendez | — | Chicago White Sox | Chicago White Sox signed free agent RHP Jesus Mendez to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Jose Rodriguez | — | Chicago White Sox | Chicago White Sox signed free agent RHP Jose Rodriguez to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Juan Oviedo | — | Chicago White Sox | Chicago White Sox signed free agent C Juan Oviedo to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Edwin Ramos | — | Chicago White Sox | Chicago White Sox signed free agent C Edwin Ramos to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Ronny Hernandez | — | Chicago White Sox | Chicago White Sox signed free agent C Ronny Hernandez to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Guillermo Rodriguez | — | Chicago White Sox | Chicago White Sox signed free agent SS Guillermo Rodriguez to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Ryan Castillo | — | Chicago White Sox | Chicago White Sox signed free agent 3B Ryan Castillo to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Clarence Martina | — | Washington Nationals | Washington Nationals signed free agent OF Clarence Martina to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Johanfran Garcia | — | Boston Red Sox | Boston Red Sox signed free agent C Johanfran Garcia to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Freili Encarnacion | — | Boston Red Sox | Boston Red Sox signed free agent SS Freili Encarnacion to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Jancel Santana | — | Boston Red Sox | Boston Red Sox signed free agent SS Jancel Santana to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Yosander Asencio | — | Boston Red Sox | Boston Red Sox signed free agent SS Yosander Asencio to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Natanael Yuten | — | Boston Red Sox | Boston Red Sox signed free agent CF Natanael Yuten to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Luis Cohen | — | Boston Red Sox | Boston Red Sox signed free agent RHP Luis Cohen to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Willian Colmenares | — | Boston Red Sox | Boston Red Sox signed free agent RHP Willian Colmenares to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Inmer Lobo | — | Boston Red Sox | Boston Red Sox signed free agent LHP Inmer Lobo to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Fraymi De Leon | — | Boston Red Sox | Boston Red Sox signed free agent SS Fraymi De Leon to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Darlyn De La Cruz | — | Boston Red Sox | Boston Red Sox signed free agent RHP Darlyn De La Cruz to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Franyer Noria | — | Boston Red Sox | Boston Red Sox signed free agent SS Franyer Noria to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Jhon Cabral | — | Miami Marlins | Miami Marlins signed free agent RHP Jhon Cabral to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Luis Cesar | — | Miami Marlins | Miami Marlins signed free agent LHP Luis Cesar to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Rodolfo De La Cruz | — | Miami Marlins | Miami Marlins signed free agent RHP Rodolfo De La Cruz to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Eiver Espinoza | — | Miami Marlins | Miami Marlins signed free agent RHP Eiver Espinoza. |
| Jun 1, 2022 | Signed as free agent | Lester Nin | — | Miami Marlins | Miami Marlins signed free agent RHP Lester Nin to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Luifer Romero | — | Miami Marlins | Miami Marlins signed free agent LHP Luifer Romero to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Elian Serrata | — | Miami Marlins | Miami Marlins signed free agent RHP Elian Serrata to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Alfonso Suriel | — | Miami Marlins | Miami Marlins signed free agent LHP Alfonso Suriel to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Mado Villegas | — | Miami Marlins | Miami Marlins signed free agent RHP Mado Villegas to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Nestor Rios | — | Miami Marlins | Miami Marlins signed free agent C Nestor Rios to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Carlos Sanchez | — | Miami Marlins | Miami Marlins signed free agent C Carlos Sanchez to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Lisandro Bonifacio | — | Miami Marlins | Miami Marlins signed free agent SS Lisandro Bonifacio to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Jose Rivera | — | Miami Marlins | Miami Marlins signed free agent 2B Jose Rivera to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Byron Chourio | — | Miami Marlins | Miami Marlins signed free agent OF Byron Chourio to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Jose Gerardo | — | Miami Marlins | Miami Marlins signed free agent OF Jose Gerardo to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Jose Monserrate | — | Miami Marlins | Miami Marlins signed free agent OF Jose Monserrate to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Julio Mendez | — | Miami Marlins | Miami Marlins signed free agent LHP Julio Mendez to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Kevin Novoa | — | Miami Marlins | Miami Marlins signed free agent C Kevin Novoa to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Yoffry Solano | — | Miami Marlins | Miami Marlins signed free agent SS Yoffry Solano to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Rafael Brito | — | Miami Marlins | Miami Marlins signed free agent RHP Rafael Brito to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Willian Campos | — | Miami Marlins | Miami Marlins signed free agent RHP Willian Campos to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Walin Castillo | — | Miami Marlins | Miami Marlins signed free agent RHP Walin Castillo to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | José Fernández | — | Miami Marlins | Miami Marlins signed free agent RHP Jose Fernandez to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Johandry Fuente | — | Miami Marlins | Miami Marlins signed free agent RHP Johandry Fuente to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Juan Ortega | — | Miami Marlins | Miami Marlins signed free agent RHP Juan Ortega to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Erinson Reyes | — | Miami Marlins | Miami Marlins signed free agent RHP Erinson Reyes to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Cristian Rueda | — | Miami Marlins | Miami Marlins signed free agent RHP Cristian Rueda to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Santiago Suarez | — | Miami Marlins | Miami Marlins signed free agent RHP Santiago Suarez to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Jonas Uzcategui | — | Miami Marlins | Miami Marlins signed free agent LHP Jonas Uzcategui to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Cherif Neymour | — | Miami Marlins | Miami Marlins signed free agent SS Cherif Neymour to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Danny Gonzalez | — | Miami Marlins | Miami Marlins signed free agent OF Danny Gonzalez to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Deivis Mosquera | — | Miami Marlins | Miami Marlins signed free agent OF Deivis Mosquera to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Toby Simmons | — | Miami Marlins | Miami Marlins signed free agent OF Toby Simmons to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Aldrin Batista | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Aldrin Batista to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Ricardo Montero | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Ricardo Montero to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Alexander Albertus | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent SS Alexander Albertus to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Eris Filpo | — | Washington Nationals | Washington Nationals signed free agent RHP Eris Filpo to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Erik Tolman | — | Washington Nationals | Washington Nationals signed free agent LHP Erik Tolman to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Rolando Gutierrez | — | Atlanta Braves | Atlanta Braves signed free agent LHP Rolando Gutierrez to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Leiker Figueroa | — | Atlanta Braves | Atlanta Braves signed free agent SS Leiker Figueroa to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Alexander Martinez | — | Atlanta Braves | Atlanta Braves signed free agent C Alexander Martinez. |
| Jun 1, 2022 | Signed as free agent | Joseilyn Gonzalez | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Joseilyn Gonzalez to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Eizon Delgado | — | San Diego Padres | San Diego Padres signed free agent OF Eizon Delgado to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Oliver Cedeno | — | San Diego Padres | San Diego Padres signed free agent 2B Oliver Cedeno to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Neifi Vasquez | — | Tampa Bay Rays | Tampa Bay Rays signed free agent OF Neifi Vasquez to a minor league contract. |
| Jun 1, 2022 | Signed as free agent | Alejandro Nuñez | — | Houston Astros | Houston Astros signed free agent SS Alejandro Nunez to a minor league contract. |
| May 31, 2022 | Signed as free agent | Adrian Sampson | — | Chicago Cubs | Chicago Cubs signed free agent RHP Adrian Sampson to a minor league contract. |
| May 31, 2022 | Released | Justin Grimm | — | Athletics | Oakland Athletics released RHP Justin Grimm. |
| May 31, 2022 | Trade | Luis Chevalier | Seattle Mariners | Cincinnati Reds | Seattle Mariners traded SS Luis Chevalier to Cincinnati Reds. |
| May 31, 2022 | Signed as free agent | Wilson Lopez | — | New York Mets | New York Mets signed free agent RHP Wilson Lopez to a minor league contract. |
| May 31, 2022 | Signed as free agent | Kyle Mora | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Kyle Mora to a minor league contract. |
| May 31, 2022 | Signed as free agent | Kenny Ogg | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Kenny Ogg to a minor league contract. |
| May 31, 2022 | Signed as free agent | Brent Teller | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Brent Teller to a minor league contract. |
| May 30, 2022 | Trade | Yu Chang | Cleveland Guardians | Pittsburgh Pirates | Cleveland Guardians traded SS Yu Chang to Pittsburgh Pirates. |
| May 30, 2022 | Released | Dallas Keuchel | — | Chicago White Sox | Chicago White Sox released LHP Dallas Keuchel. |
| May 30, 2022 | Trade | John Andreoli | Philadelphia Phillies | Minnesota Twins | Philadelphia Phillies traded RF John Andreoli to Minnesota Twins. |
| May 30, 2022 | Signed as free agent | Elvis Peralta | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent SS Elvis Peralta to a minor league contract. |
| May 30, 2022 | Trade | Jose Acosta | Texas Rangers | Milwaukee Brewers | Texas Rangers traded 2B Jose Acosta to Milwaukee Brewers. |
| May 30, 2022 | Signed as free agent | Michael Perez | — | Miami Marlins | Miami Marlins signed free agent RHP Michael Perez to a minor league contract. |
| May 30, 2022 | Signed as free agent | Braulio Salas | — | Miami Marlins | Miami Marlins signed free agent RHP Braulio Salas to a minor league contract. |
| May 29, 2022 | Signed as free agent | Rob Brantly | — | New York Yankees | New York Yankees signed free agent C Rob Brantly to a minor league contract. |
| May 29, 2022 | Released | Tyler Thornburg | — | Atlanta Braves | Atlanta Braves released RHP Tyler Thornburg. |
| May 29, 2022 | Signed as free agent | Mitch Nay | — | Los Angeles Angels | Los Angeles Angels signed free agent 3B Mitch Nay to a minor league contract. |
| May 28, 2022 | Trade | JT Riddle | Cincinnati Reds | New York Mets | Cincinnati Reds traded SS JT Riddle to New York Mets. |
| May 27, 2022 | Signed as free agent | Adolfo Oviedo | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent RHP Adolfo Oviedo to a minor league contract. |
| May 27, 2022 | Signed as free agent | Luis Rodriguez | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent RHP Luis Rodriguez to a minor league contract. |
| May 27, 2022 | Signed as free agent | Ildemaro Vargas | — | Washington Nationals | Washington Nationals signed free agent 2B Ildemaro Vargas to a minor league contract. |
| May 27, 2022 | Signed as free agent | Leofanny Medina | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP Leofanny Medina to a minor league contract. |
| May 27, 2022 | Signed as free agent | Axel Acevedo | — | Chicago White Sox | Chicago White Sox signed free agent RHP Axel Acevedo to a minor league contract. |
| May 27, 2022 | Signed as free agent | Kengri De Los Santos | — | Miami Marlins | Miami Marlins signed free agent SS Kengri De Los Santos to a minor league contract. |
| May 27, 2022 | Signed | Athanael Duarte | — | Los Angeles Angels | Los Angeles Angels signed IF Athanael Duarte. |
| May 27, 2022 | Signed as free agent | Franklin Paulino | — | Detroit Tigers | Detroit Tigers signed free agent RHP Franklin Paulino to a minor league contract. |
| May 26, 2022 | Signed as free agent | Matt Carpenter | — | New York Yankees | New York Yankees signed free agent 3B Matt Carpenter and. |
| May 26, 2022 | Signed as free agent | Shane Greene | — | New York Yankees | New York Yankees signed free agent RHP Shane Greene to a minor league contract. |
| May 26, 2022 | Released | T.J. Zeuch | — | St. Louis Cardinals | St. Louis Cardinals released RHP T.J. Zeuch. |
| May 26, 2022 | Signed as free agent | Deck McGuire | — | Cincinnati Reds | Cincinnati Reds signed free agent RHP Deck McGuire to a minor league contract. |
| May 26, 2022 | Signed as free agent | Justin Nicolino | — | Cincinnati Reds | Cincinnati Reds signed free agent LHP Justin Nicolino to a minor league contract. |
| May 26, 2022 | Signed as free agent | Juan Mercedes | — | Minnesota Twins | Minnesota Twins signed free agent RHP Juan Mercedes to a minor league contract. |
| May 25, 2022 | Signed as free agent | Brett Kennedy | — | Boston Red Sox | Boston Red Sox signed free agent RHP Brett Kennedy to a minor league contract. |
| May 25, 2022 | Signed as free agent | A.J. Ladwig | — | Miami Marlins | Miami Marlins signed free agent RHP A.J. Ladwig to a minor league contract. |
| May 25, 2022 | Trade | Daniel Johnson | Cleveland Guardians | New York Mets | Cleveland Guardians traded RF Daniel Johnson to New York Mets. |
| May 25, 2022 | Signed as free agent | Cory Wilder | — | Cincinnati Reds | Cincinnati Reds signed free agent RHP Cory Wilder to a minor league contract. |
| May 25, 2022 | Signed as free agent | Luis Victorino | — | Houston Astros | Houston Astros signed free agent RHP Luis Victorino to a minor league contract. |
| May 25, 2022 | Signed as free agent | Marco Vargas | — | Miami Marlins | Miami Marlins signed free agent 2B Marco Vargas to a minor league contract. |
| May 25, 2022 | Signed as free agent | Mauricio Serrano | — | Miami Marlins | Miami Marlins signed free agent SS Mauricio Serrano to a minor league contract. |
| May 25, 2022 | Signed as free agent | Roman Perez | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Roman Perez to a minor league contract. |
| May 25, 2022 | Signed as free agent | Karell Paz | — | New York Mets | New York Mets signed free agent OF Karell Paz to a minor league contract. |
| May 25, 2022 | Signed as free agent | Keninson Diaz | — | New York Yankees | New York Yankees signed free agent RHP Keninson Diaz. |
| May 25, 2022 | Signed as free agent | Oliver Yan | — | Texas Rangers | Texas Rangers signed free agent OF Oliver Yan to a minor league contract. |
| May 25, 2022 | Signed as free agent | Kyle Wilcox | — | Atlanta Braves | Atlanta Braves signed free agent RHP Kyle Wilcox to a minor league contract. |
| May 25, 2022 | Signed as free agent | Nick Richmond | — | Baltimore Orioles | Baltimore Orioles signed free agent RHP Nick Richmond to a minor league contract. |
| May 25, 2022 | Signed as free agent | Camilo Hernandez | — | Athletics | Oakland Athletics signed free agent RHP Camilo Hernandez to a minor league contract. |
| May 25, 2022 | Signed as free agent | Elvis Rijo | — | Athletics | Oakland Athletics signed free agent SS Elvis Rijo to a minor league contract. |
| May 25, 2022 | Signed as free agent | Jonathan Batista | — | Cincinnati Reds | Cincinnati Reds signed free agent RHP Jonathan Batista to a minor league contract. |
| May 25, 2022 | Signed as free agent | Anthony Bello | — | Baltimore Orioles | Baltimore Orioles signed free agent Anthony Bello to a minor league contract. |
| May 25, 2022 | Signed as free agent | Jesus Colina | — | Cincinnati Reds | Cincinnati Reds signed free agent RHP Jesus Colina to a minor league contract. |
| May 25, 2022 | Signed as free agent | Anger Romero | — | Boston Red Sox | Boston Red Sox signed free agent C Anger Romero to a minor league contract. |
| May 24, 2022 | Signed as free agent | José Briceño | — | Kansas City Royals | Kansas City Royals signed free agent C Jose Briceno to a minor league contract. |
| May 24, 2022 | Signed as free agent | Hunter Wood | — | Minnesota Twins | Minnesota Twins signed free agent RHP Hunter Wood to a minor league contract. |
| May 24, 2022 | Signed as free agent | Wander Rosario | — | New York Mets | New York Mets signed free agent RHP Wander Rosario to a minor league contract. |
| May 24, 2022 | Signed as free agent | Odue Civada | — | Athletics | Oakland Athletics signed free agent RHP Odue Civada to a minor league contract. |
| May 24, 2022 | Signed as free agent | Nick Fanti | — | Philadelphia Phillies | Philadelphia Phillies signed free agent LHP Nick Fanti to a minor league contract. |
| May 24, 2022 | Signed as free agent | Michael Flynn | — | Seattle Mariners | Seattle Mariners signed free agent RHP Michael Flynn to a minor league contract. |
| May 24, 2022 | Signed as free agent | Eric Yardley | — | Toronto Blue Jays | Toronto Blue Jays signed free agent RHP Eric Yardley to a minor league contract. |
| May 24, 2022 | Signed as free agent | A.J. Candelario | — | Washington Nationals | Washington Nationals signed free agent RHP A.J. Candelario to a minor league contract. |
| May 24, 2022 | Signed as free agent | Riley Mahan | — | San Francisco Giants | San Francisco Giants signed free agent 2B Riley Mahan to a minor league contract. |
| May 24, 2022 | Trade | Francisco Lucumi | Los Angeles Dodgers | Toronto Blue Jays | Los Angeles Dodgers traded RHP Francisco Lucumi to Toronto Blue Jays. |
| May 23, 2022 | Released | Steven Souza Jr. | — | Seattle Mariners | Seattle Mariners released RF Steven Souza Jr.. |
| May 23, 2022 | Trade | Jean Herrera | Los Angeles Dodgers | Arizona Diamondbacks | Los Angeles Dodgers traded RHP Jean Herrera to Arizona Diamondbacks. |
| May 23, 2022 | Signed as free agent | Franklin Gil | — | Houston Astros | Houston Astros signed free agent RHP Franklin Gil to a minor league contract. |
| May 22, 2022 | Trade | Andrew Shaps | Los Angeles Dodgers | Detroit Tigers | Los Angeles Dodgers traded LHP Andrew Shaps to Detroit Tigers. |
| May 21, 2022 | Signed as free agent | Grant Dayton | — | Los Angeles Angels | Los Angeles Angels signed free agent LHP Grant Dayton to a minor league contract. |
| May 21, 2022 | Signed as free agent | Justin Upton | — | Seattle Mariners | Seattle Mariners signed free agent LF Justin Upton. |
| May 21, 2022 | Signed as free agent | Andrew Knapp | — | Seattle Mariners | Seattle Mariners signed free agent C Andrew Knapp to a minor league contract. |
| May 20, 2022 | Signed as free agent | Rabel Colon | — | Houston Astros | Houston Astros signed free agent OF Rabel Colon to a minor league contract. |
| May 20, 2022 | Signed as free agent | Wilmy Sanchez | — | Houston Astros | Houston Astros signed free agent RHP Wilmy Sanchez to a minor league contract. |
| May 20, 2022 | Signed as free agent | Tanner Gaff | — | Minnesota Twins | Minnesota Twins signed free agent RHP Tanner Gaff to a minor league contract. |
| May 20, 2022 | Signed as free agent | Gregoris Chalas | — | Detroit Tigers | Detroit Tigers signed free agent RHP Gregoris Chalas to a minor league contract. |
| May 20, 2022 | Signed as free agent | Albert Polanco | — | Miami Marlins | Miami Marlins signed free agent RHP Albert Polanco to a minor league contract. |
| May 19, 2022 | Signed as free agent | Trayce Thompson | — | Detroit Tigers | Detroit Tigers signed free agent RF Trayce Thompson to a minor league contract. |
| May 19, 2022 | Signed as free agent | Drew Hutchison | — | Detroit Tigers | Detroit Tigers signed free agent RHP Drew Hutchison to a minor league contract. |
| May 19, 2022 | Signed as free agent | Ryan Miller | — | New York Yankees | New York Yankees signed free agent RHP Ryan Miller to a minor league contract. |
| May 19, 2022 | Signed as free agent | Marvin Alcantara | — | Boston Red Sox | Boston Red Sox signed free agent SS Marvin Alcantara to a minor league contract. |
| May 19, 2022 | Signed as free agent | José Ureña | — | Colorado Rockies | Colorado Rockies signed free agent RHP Jose Urena to a minor league contract. |
| May 19, 2022 | Signed as free agent | Dylan Burns | — | Chicago White Sox | Chicago White Sox signed free agent RHP Dylan Burns to a minor league contract. |
| May 19, 2022 | Signed as free agent | Logan Lyle | — | Chicago White Sox | Chicago White Sox signed free agent LHP Logan Lyle to a minor league contract. |
| May 19, 2022 | Signed as free agent | Geremy Guerrero | — | Houston Astros | Houston Astros signed free agent LHP Geremy Guerrero to a minor league contract. |
| May 19, 2022 | Signed as free agent | Pedro Báez | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Pedro Baez to a minor league contract. |
| May 19, 2022 | Signed as free agent | Andre Sanchez | — | Los Angeles Angels | Los Angeles Angels signed free agent RHP Andre Sanchez to a minor league contract. |
| May 19, 2022 | Signed as free agent | Trevor Cahill | — | New York Mets | New York Mets signed free agent RHP Trevor Cahill to a minor league contract. |
| May 19, 2022 | Signed as free agent | Rafelin Nivar | — | New York Yankees | New York Yankees signed free agent LHP Rafaelin Nivar to a minor league contract. |
| May 19, 2022 | Signed as free agent | Zack Plunkett | — | Athletics | Oakland Athletics signed free agent C Zack Plunkett to a minor league contract. |
| May 19, 2022 | Signed as free agent | Roni Cabrera | — | Texas Rangers | Texas Rangers signed free agent OF Roni Cabrera to a minor league contract. |
| May 19, 2022 | Signed as free agent | Jeffry Filion | — | Kansas City Royals | Kansas City Royals signed free agent C Jeffry Filion to a minor league contract. |
| May 19, 2022 | Signed as free agent | Garrett McDaniels | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent LHP Garrett McDaniels to a minor league contract. |
| May 18, 2022 | Trade | Luis Osorio | Arizona Diamondbacks | Baltimore Orioles | Baltimore Orioles traded LHP Paul Fry to Arizona Diamondbacks for RHP Luis Osorio. |
| May 18, 2022 | Signed as free agent | Erbin Jaque | — | Chicago Cubs | Chicago Cubs signed free agent OF Erbin Jaque to a minor league contract. |
| May 18, 2022 | Signed as free agent | Alfredo Romero | — | Chicago Cubs | Chicago Cubs signed free agent RHP Alfredo Romero. |
| May 18, 2022 | Signed as free agent | Estiven Giron | — | San Diego Padres | San Diego Padres signed free agent C Estiven Giron to a minor league contract. |
| May 18, 2022 | Signed as free agent | Miguel Camacho | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Miguel Camacho to a minor league contract. |
| May 18, 2022 | Signed as free agent | Onias Jimenez | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Onias Jimenez to a minor league contract. |
| May 17, 2022 | Signed as free agent | Cristofher Carrasco | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Cristofher Carrasco to a minor league contract. |
| May 17, 2022 | Signed as free agent | Bawin Colon | — | Texas Rangers | Texas Rangers signed free agent RHP Bawin Colon to a minor league contract. |
| May 17, 2022 | Signed as free agent | Danery Tejada | — | Texas Rangers | Texas Rangers signed free agent RHP Danery Tejada to a minor league contract. |
| May 16, 2022 | Trade | Yohan Ramírez | Seattle Mariners | Cleveland Guardians | Seattle Mariners traded RHP Yohan Ramirez to Cleveland Guardians. |
| May 16, 2022 | Signed as free agent | Patrick Murphy | — | Miami Marlins | Miami Marlins signed free agent LHP Patrick Murphy to a minor league contract. |
| May 16, 2022 | Signed as free agent | Jorge Juan | — | Athletics | Oakland Athletics signed free agent RHP Jorge Juan to a minor league contract. |
| May 16, 2022 | Signed as free agent | Spencer Bivens | — | San Francisco Giants | San Francisco Giants signed free agent RHP Spencer Bivens to a minor league contract. |
| May 16, 2022 | Signed as free agent | Wellington Guzman | — | Atlanta Braves | Atlanta Braves signed free agent RHP Wellington Guzman to a minor league contract. |
| May 16, 2022 | Signed as free agent | Andres Ramos | — | Detroit Tigers | Detroit Tigers signed free agent RHP Andres Ramos to a minor league contract. |
| May 16, 2022 | Signed as free agent | Andrews Sosa | — | Houston Astros | Houston Astros signed free agent C Andrews Sosa to a minor league contract. |
| May 16, 2022 | Signed as free agent | July Vittini | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent C July Vittini to a minor league contract. |
| May 14, 2022 | Trade | Michael Papierski | Houston Astros | San Francisco Giants | San Francisco Giants traded SS Mauricio Dubon to Houston Astros for C Michael Papierski. |
| May 14, 2022 | Trade | Josh Roberson | Miami Marlins | Tampa Bay Rays | Miami Marlins traded RHP Josh Roberson to Tampa Bay Rays. |
| May 14, 2022 | Trade | Unnamed | San Francisco Giants | Seattle Mariners | Seattle Mariners traded OF Stuart Fairchild to San Francisco Giants for 2B Alex Blandino and cash. |
| May 14, 2022 | Signed as free agent | Ricardo Gomez | — | Chicago White Sox | Chicago White Sox signed free agent RHP Ricardo Gomez to a minor league contract. |
| May 13, 2022 | Signed as free agent | Robinson Canó | — | San Diego Padres | San Diego Padres signed free agent 2B Robinson Cano. |
| May 13, 2022 | Signed as free agent | Dylan Castaneda | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Dylan Castaneda to a minor league contract. |
| May 13, 2022 | Signed as free agent | Dillon Larsen | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent LHP Dillon Larsen to a minor league contract. |
| May 13, 2022 | Signed as free agent | Danny Salazar | — | New York Yankees | New York Yankees signed free agent RHP Danny Salazar to a minor league contract. |
| May 13, 2022 | Signed as free agent | Andrew Miller | — | Seattle Mariners | Seattle Mariners signed free agent C Andrew Miller to a minor league contract. |
| May 13, 2022 | Signed as free agent | Luke Roskam | — | Seattle Mariners | Seattle Mariners signed free agent C Luke Roskam to a minor league contract. |
| May 13, 2022 | Signed as free agent | Rafael Sanchez | — | Toronto Blue Jays | Toronto Blue Jays signed free agent RHP Rafael Sanchez to a minor league contract. |
| May 13, 2022 | Signed as free agent | Ricardo Brizuela | — | Chicago White Sox | Chicago White Sox signed free agent RHP Ricardo Brizuela to a minor league contract. |
| May 13, 2022 | Signed as free agent | Juan Jimenez | — | Chicago White Sox | Chicago White Sox signed free agent RHP Juan Jimenez to a minor league contract. |
| May 13, 2022 | Signed as free agent | Gregory Mota | — | Miami Marlins | Miami Marlins signed free agent IF Gregory Mota to a minor league contract. |
| May 12, 2022 | Trade | Unnamed | Seattle Mariners | San Francisco Giants | San Francisco Giants traded 1B Mike Ford to Seattle Mariners for cash. |
| May 12, 2022 | Signed as free agent | Unnamed | — | Toronto Blue Jays | Toronto Blue Jays signed free agent RHP Rafael Diaz to a minor league contract. |
| May 12, 2022 | Signed as free agent | Jose Leandro | — | Baltimore Orioles | Baltimore Orioles signed free agent LHP Jose Leandro to a minor league contract. |
| May 11, 2022 | Trade | Donovan Walton | Seattle Mariners | San Francisco Giants | San Francisco Giants traded RHP Prelander Berroa to Seattle Mariners for 2B Donovan Walton. |
| May 11, 2022 | Signed as free agent | Kevin Herget | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP Kevin Herget to a minor league contract. |
| May 11, 2022 | Signed as free agent | Matt Mogollon | — | Seattle Mariners | Seattle Mariners signed free agent RHP Matt Mogollon to a minor league contract. |
| May 11, 2022 | Signed as free agent | Bryan Warzek | — | Seattle Mariners | Seattle Mariners signed free agent LHP Bryan Warzek to a minor league contract. |
| May 11, 2022 | Signed as free agent | Joe Wieland | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP Joe Wieland to a minor league contract. |
| May 11, 2022 | Signed as free agent | Carlos Cauro | — | Houston Astros | Houston Astros signed free agent C Carlos Cauro to a minor league contract. |
| May 11, 2022 | Signed as free agent | Fares Sanchez | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent RHP Fares Sanchez to a minor league contract. |
| May 10, 2022 | Signed as free agent | Buck Farmer | — | Cincinnati Reds | Cincinnati Reds signed free agent RHP Buck Farmer to a minor league contract. |
| May 10, 2022 | Signed as free agent | Matt Davidson | — | Athletics | Oakland Athletics signed free agent DH Matt Davidson to a minor league contract. |
| May 10, 2022 | Signed as free agent | Connor Kaiser | — | San Diego Padres | San Diego Padres signed free agent SS Connor Kaiser to a minor league contract. |
| May 10, 2022 | Signed as free agent | Shawn Armstrong | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP Shawn Armstrong to a minor league contract. |
| May 10, 2022 | Signed as free agent | Hector Perez | — | Baltimore Orioles | Baltimore Orioles signed free agent RHP Hector Perez to a minor league contract. |
| May 10, 2022 | Signed as free agent | Sabier Marte | — | New York Yankees | New York Yankees signed free agent RHP Sabier Marte to a minor league contract. |
| May 10, 2022 | Signed as free agent | Yeri Perez | — | Kansas City Royals | Kansas City Royals signed free agent RHP Yeri Perez to a minor league contract. |
| May 9, 2022 | Signed as free agent | Shogo Akiyama | — | San Diego Padres | San Diego Padres signed free agent OF Shogo Akiyama to a minor league contract. |
| May 9, 2022 | Signed as free agent | Walker Lockett | — | Cincinnati Reds | Cincinnati Reds signed free agent RHP Walker Lockett to a minor league contract. |
| May 9, 2022 | Signed as free agent | Carlos Mendoza | — | Boston Red Sox | Boston Red Sox signed free agent RHP Carlos Mendoza to a minor league contract. |
| May 9, 2022 | Signed as free agent | Keduar Trujillo | — | Houston Astros | Houston Astros signed free agent C Kedaur Trujillo to a minor league contract. |
| May 8, 2022 | Signed as free agent | Luke Farrell | — | Chicago Cubs | Chicago Cubs signed free agent RHP Luke Farrell to a minor league contract. |
| May 8, 2022 | Signed as free agent | Juan Lagares | — | Los Angeles Angels | Los Angeles Angels signed free agent CF Juan Lagares to a minor league contract. |
| May 8, 2022 | Trade | Manuel Garcia | Arizona Diamondbacks | Detroit Tigers | Arizona Diamondbacks traded C Manuel Garcia to Detroit Tigers. |
| May 8, 2022 | Released | Jorge Juan | — | Athletics | Oakland Athletics released RHP Jorge Juan. |
| May 8, 2022 | Released | Robinson Canó | — | New York Mets | New York Mets released 2B Robinson Cano. |
| May 8, 2022 | Trade | Corey Oswalt | San Francisco Giants | Philadelphia Phillies | San Francisco Giants traded RHP Corey Oswalt to Philadelphia Phillies. |
| May 7, 2022 | Signed as free agent | Carlos Martinez | — | Boston Red Sox | Boston Red Sox signed free agent RHP Carlos Martinez to a minor league contract. |
| May 7, 2022 | Signed as free agent | Kleyderve Andrade | — | Philadelphia Phillies | Philadelphia Phillies signed free agent LHP Kleyderve Andrade to a minor league contract. |
| May 7, 2022 | Signed as free agent | Ronald Contreras | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP Ronald Contreras to a minor league contract. |
| May 5, 2022 | Signed as free agent | Derek Holland | — | Toronto Blue Jays | Toronto Blue Jays signed free agent LHP Derek Holland to a minor league contract. |
| May 5, 2022 | Signed as free agent | Chris Sharpe | — | Philadelphia Phillies | Philadelphia Phillies signed free agent CF Chris Sharpe to a minor league contract. |
| May 5, 2022 | Signed as free agent | Yeiber Cartaya | — | Baltimore Orioles | Baltimore Orioles signed free agent RHP Yeiber Cartaya to a minor league contract. |
| May 4, 2022 | Signed as free agent | Darien Núñez | — | San Francisco Giants | San Francisco Giants signed free agent LHP Darien Nunez to a minor league contract. |
| May 4, 2022 | Signed as free agent | Nelson Sevilla | — | Colorado Rockies | Colorado Rockies signed free agent RHP Nelson Sevilla to a minor league contract. |
| May 4, 2022 | Signed as free agent | Bill Villanueva | — | Colorado Rockies | Colorado Rockies signed free agent RHP Bill Villanueva to a minor league contract. |
| May 4, 2022 | Signed as free agent | Eliseo Mota | — | Detroit Tigers | Detroit Tigers signed free agent RHP Eliseo Mota to a minor league contract. |
| May 4, 2022 | Signed as free agent | Luis Camilo | — | Detroit Tigers | Detroit Tigers signed free agent LHP Luis Camilo to a minor league contract. |
| May 4, 2022 | Signed as free agent | Eiker Huizi | — | Detroit Tigers | Detroit Tigers signed free agent RHP Eiker Huizi to a minor league contract. |
| May 4, 2022 | Signed as free agent | Henry Montilla | — | Detroit Tigers | Detroit Tigers signed free agent RHP Henry Montilla to a minor league contract. |
| May 4, 2022 | Signed as free agent | Mac Lardner | — | Athletics | Oakland Athletics signed free agent LHP Mac Lardner to a minor league contract. |
| May 4, 2022 | Signed as free agent | Richard Fernandez | — | Athletics | Oakland Athletics signed free agent RHP Richard Fernandez to a minor league contract. |
| May 4, 2022 | Signed as free agent | Ramon Vasquez | — | Athletics | Oakland Athletics signed free agent RHP Ramon Vasquez to a minor league contract. |
| May 4, 2022 | Signed as free agent | Felix Castro | — | Athletics | Oakland Athletics signed free agent RHP Felix Castro to a minor league contract. |
| May 4, 2022 | Signed as free agent | Wilmi Vizcaino | — | Athletics | Oakland Athletics signed free agent RHP Wilmi Vizcaino to a minor league contract. |
| May 4, 2022 | Signed as free agent | Elvi Lina | — | Athletics | Oakland Athletics signed free agent RHP Elvi Lina to a minor league contract. |
| May 3, 2022 | Signed as free agent | Brody Koerner | — | Chicago White Sox | Chicago White Sox signed free agent RHP Brody Koerner to a minor league contract. |
| May 3, 2022 | Signed as free agent | Luke Summers | — | Colorado Rockies | Colorado Rockies signed free agent RHP Luke Summers to a minor league contract. |
| May 3, 2022 | Signed as free agent | Nick Burdi | — | San Diego Padres | San Diego Padres signed free agent RHP Nick Burdi to a minor league contract. |
| May 3, 2022 | Signed as free agent | Yusmeiro Petit | — | San Diego Padres | San Diego Padres signed free agent RHP Yusmeiro Petit to a minor league contract. |
| May 3, 2022 | Signed as free agent | Scott Alexander | — | San Francisco Giants | San Francisco Giants signed free agent LHP Scott Alexander to a minor league contract. |
| May 3, 2022 | Signed as free agent | Anthony Alford | — | Cleveland Guardians | Cleveland Guardians signed free agent LF Anthony Alford to a minor league contract. |
| May 3, 2022 | Signed as free agent | Fernando Abad | — | Seattle Mariners | Seattle Mariners signed free agent LHP Fernando Abad to a minor league contract. |
| May 3, 2022 | Signed as free agent | Cesar Lares | — | Minnesota Twins | Minnesota Twins signed free agent LHP Cesar Lares to a minor league contract. |
| May 2, 2022 | Signed as free agent | Isidro Adon | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Isidro Adon to a minor league contract. |
| May 2, 2022 | Signed as free agent | Rolando Casihis | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent LHP Rolando Casihis to a minor league contract. |
| May 2, 2022 | Signed as free agent | Yoendris Gonzalez | — | Chicago Cubs | Chicago Cubs signed free agent RHP Yoendris Gonzalez to a minor league contract. |
| May 2, 2022 | Signed as free agent | Jonatan Yan | — | Athletics | Oakland Athletics signed free agent OF Jonatan Yan to a minor league contract. |
| May 2, 2022 | Signed as free agent | Bjay Cooke | — | Athletics | Oakland Athletics signed free agent RHP Bailey-Jay Cooke to a minor league contract. |
| May 2, 2022 | Signed as free agent | Cristian Monegro | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Cristian Monegro to a minor league contract. |
| Apr 30, 2022 | Signed as free agent | Konner Wade | — | Seattle Mariners | Seattle Mariners signed free agent RHP Konner Wade to a minor league contract. |
| Apr 30, 2022 | Trade | Unnamed | San Francisco Giants | Miami Marlins | Miami Marlins traded SS Isan Diaz to San Francisco Giants for cash. |
| Apr 30, 2022 | Signed as free agent | Bianger Liendo | — | Minnesota Twins | Minnesota Twins signed free agent RHP Bianger Liendo to a minor league contract. |
| Apr 30, 2022 | Signed as free agent | Eddy Felix | — | Detroit Tigers | Detroit Tigers signed free agent RHP Eddy Felix to a minor league contract. |
| Apr 29, 2022 | Released | Darien Núñez | — | San Francisco Giants | San Francisco Giants released LHP Darien Nunez. |
| Apr 29, 2022 | Signed as free agent | Rafael Dolis | — | Chicago White Sox | Chicago White Sox signed free agent RHP Rafael Dolis to a minor league contract. |
| Apr 29, 2022 | Signed as free agent | Cristofher Paniagua | — | Boston Red Sox | Boston Red Sox signed free agent OF Cristofher Paniagua to a minor league contract. |
| Apr 28, 2022 | Released | Oliver Pérez | — | Arizona Diamondbacks | Arizona Diamondbacks released LHP Oliver Perez. |
| Apr 28, 2022 | Signed as free agent | Tommy Hunter | — | New York Mets | New York Mets signed free agent RHP Tommy Hunter to a minor league contract. |
| Apr 27, 2022 | Released | Pedro Báez | — | Houston Astros | Houston Astros released RHP Pedro Baez. |
| Apr 27, 2022 | Signed as free agent | Colby Fitch | — | Los Angeles Angels | Los Angeles Angels signed free agent C Colby Fitch to a minor league contract. |
| Apr 27, 2022 | Signed as free agent | Hernán Pérez | — | Atlanta Braves | Atlanta Braves signed free agent 3B Hernan Perez to a minor league contract. |
| Apr 27, 2022 | Signed as free agent | Claudio Gatier | — | Philadelphia Phillies | Philadelphia Phillies signed free agent P Claudio Gatier to a minor league contract. |
| Apr 27, 2022 | Signed as free agent | Edgar García | — | Washington Nationals | Washington Nationals signed free agent RHP Edgar Garcia to a minor league contract. |
| Apr 26, 2022 | Trade | Unnamed | San Francisco Giants | Seattle Mariners | Seattle Mariners traded 3B Kevin Padlo to San Francisco Giants for cash. |
| Apr 26, 2022 | Signed as free agent | Enger Sanchez | — | Colorado Rockies | Colorado Rockies signed free agent RHP Enger Sanchez to a minor league contract. |
| Apr 26, 2022 | Signed as free agent | Anthony Walters | — | Colorado Rockies | Colorado Rockies signed free agent SS Anthony Walters to a minor league contract. |
| Apr 26, 2022 | Signed as free agent | Ryley Widell | — | Colorado Rockies | Colorado Rockies signed free agent LHP Ryley Widell to a minor league contract. |
| Apr 25, 2022 | Released | Darien Núñez | — | Los Angeles Dodgers | Los Angeles Dodgers released LHP Darien Nunez. |
| Apr 25, 2022 | Signed as free agent | Michael De La Cruz | — | Detroit Tigers | Detroit Tigers signed free agent C Michael De La Cruz to a minor league contract. |
| Apr 25, 2022 | Signed as free agent | Juan Diaz | — | Miami Marlins | Miami Marlins signed free agent LHP Juan Diaz to a minor league contract. |
| Apr 25, 2022 | Signed as free agent | Franklyn Kilome | — | Washington Nationals | Washington Nationals signed free agent RHP Franklyn Kilome to a minor league contract. |
| Apr 25, 2022 | Signed as free agent | Miguel Fernandez | — | Washington Nationals | Washington Nationals signed free agent OF Miguel Fernandez to a minor league contract. |
| Apr 25, 2022 | Signed as free agent | Angelo Martinez | — | Houston Astros | Houston Astros signed free agent RHP Angelo Martinez to a minor league contract. |
| Apr 24, 2022 | Trade | Matt Peacock | Arizona Diamondbacks | Kansas City Royals | Arizona Diamondbacks traded RHP Matt Peacock to Kansas City Royals for cash. |
| Apr 23, 2022 | Trade | Unnamed | Seattle Mariners | Arizona Diamondbacks | Arizona Diamondbacks traded OF Stuart Fairchild to Seattle Mariners for cash. |
| Apr 22, 2022 | Signed as free agent | Danny Dopico | — | Washington Nationals | Washington Nationals signed free agent RHP Danny Dopico to a minor league contract. |
| Apr 22, 2022 | Signed as free agent | Jackson Sigman | — | Seattle Mariners | Seattle Mariners signed free agent RHP Jackson Sigman to a minor league contract. |
| Apr 22, 2022 | Signed as free agent | Taylor Motter | — | Cincinnati Reds | Cincinnati Reds signed free agent 2B Taylor Motter to a minor league contract. |
| Apr 22, 2022 | Signed as free agent | Yoanis Aleksandrov | — | Chicago Cubs | Chicago Cubs signed free agent C Yoanis Aleksandrov to a minor league contract. |
| Apr 22, 2022 | Signed as free agent | Dilver Gomez | — | Chicago Cubs | Chicago Cubs signed free agent C Dilver Gomez to a minor league contract. |
| Apr 22, 2022 | Signed as free agent | Alex Paredes | — | Cleveland Guardians | Cleveland Guardians signed free agent C Alex Paredes to a minor league contract. |
| Apr 22, 2022 | Signed as free agent | Christian Sepulveda | — | Los Angeles Angels | Los Angeles Angels signed free agent SS Christian Sepulveda to a minor league contract. |
| Apr 22, 2022 | Signed as free agent | Enrique Coronel | — | Houston Astros | Houston Astros signed free agent RHP Enrique Coronel to a minor league contract. |
| Apr 22, 2022 | Signed as free agent | Jose Guedez | — | Houston Astros | Houston Astros signed free agent RHP Jose Guedez to a minor league contract. |
| Apr 22, 2022 | Signed as free agent | Marco Patino | — | Atlanta Braves | Atlanta Braves signed free agent RHP Marco Patino to a minor league contract. |
| Apr 22, 2022 | Signed as free agent | Andres Jimenez | — | Boston Red Sox | Boston Red Sox signed free agent RHP Andres Jimenez to a minor league contract. |
| Apr 21, 2022 | Trade | Jesse Chavez | Chicago Cubs | Atlanta Braves | Atlanta Braves traded LHP Sean Newcomb to Chicago Cubs for RHP Jesse Chavez and cash. |
| Apr 21, 2022 | Trade | Cory Abbott | Chicago Cubs | San Francisco Giants | Chicago Cubs traded RHP Cory Abbott to San Francisco Giants. |
| Apr 21, 2022 | Signed as free agent | Iverson Corpas | — | Colorado Rockies | Colorado Rockies signed free agent RHP Iverson Corpas to a minor league contract. |
| Apr 21, 2022 | Signed as free agent | Zack Burdi | — | Washington Nationals | Washington Nationals signed free agent RHP Zack Burdi to a minor league contract. |
| Apr 21, 2022 | Trade | Brayan Medina | San Diego Padres | Minnesota Twins | San Diego Padres traded RHP Brayan Medina to Minnesota Twins. |
| Apr 21, 2022 | Trade | Garvin Alston | Chicago White Sox | Washington Nationals | Chicago White Sox traded LHP Garvin Alston to Washington Nationals. |
| Apr 21, 2022 | Signed as free agent | Cam Brown | — | Detroit Tigers | Detroit Tigers signed free agent RHP Cameron Brown to a minor league contract. |
| Apr 21, 2022 | Signed as free agent | Joan Delgado | — | Chicago Cubs | Chicago Cubs signed free agent OF Joan Delgado to a minor league contract. |
| Apr 21, 2022 | Signed as free agent | Wilber Rodriguez | — | Chicago Cubs | Chicago Cubs signed free agent RHP Wilber Rodriguez to a minor league contract. |
| Apr 20, 2022 | Signed as free agent | Landany Alfonseca | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP Landany Alfonseca to a minor league contract. |
| Apr 20, 2022 | Signed as free agent | Davis Polo | — | Atlanta Braves | Atlanta Braves signed free agent RHP Davis Polo to a minor league contract. |
| Apr 20, 2022 | Signed | Andres Bonolis | — | Chicago Cubs | Chicago Cubs signed OF Andres Bonolis. |
| Apr 19, 2022 | Trade | Dustin Peterson | Milwaukee Brewers | Philadelphia Phillies | Milwaukee Brewers traded LF Dustin Peterson to Philadelphia Phillies for cash. |
| Apr 19, 2022 | Signed as free agent | Kenebell Sevelen | — | Colorado Rockies | Colorado Rockies signed free agent RHP Kenebell Sevelen to a minor league contract. |
| Apr 19, 2022 | Signed as free agent | Kaleb Cowart | — | New York Yankees | New York Yankees signed free agent 3B Kaleb Cowart to a minor league contract. |
| Apr 19, 2022 | Signed as free agent | Irving Vazquez | — | Chicago Cubs | Chicago Cubs signed free agent RHP Irving Vazquez to a minor league contract. |
| Apr 18, 2022 | Signed as free agent | Tyler Krieger | — | Atlanta Braves | Atlanta Braves signed free agent 2B Tyler Krieger to a minor league contract. |
| Apr 16, 2022 | Trade | Unnamed | Tampa Bay Rays | San Diego Padres | San Diego Padres traded RHP Javy Guerra to Tampa Bay Rays for cash. |
| Apr 16, 2022 | Signed as free agent | Sandy León | — | Cincinnati Reds | Cincinnati Reds signed free agent C Sandy Leon to a minor league contract. |
| Apr 16, 2022 | Signed as free agent | Daniel Tillo | — | San Francisco Giants | San Francisco Giants signed free agent LHP Daniel Tillo to a minor league contract. |
| Apr 16, 2022 | Signed as free agent | Andres Tabares | — | Philadelphia Phillies | Philadelphia Phillies signed free agent CF Andres Tabares to a minor league contract. |
| Apr 14, 2022 | Signed as free agent | Stevie Berman | — | Toronto Blue Jays | Toronto Blue Jays signed free agent C Stevie Berman to a minor league contract. |
| Apr 14, 2022 | Signed as free agent | Edgar Aviles | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Edgar Aviles to a minor league contract. |
| Apr 14, 2022 | Signed as free agent | Jesus Peraza | — | Minnesota Twins | Minnesota Twins signed free agent C Jesus Peraza to a minor league contract. |
| Apr 14, 2022 | Signed as free agent | Ricardo Pena | — | Minnesota Twins | Minnesota Twins signed free agent C Ricardo Pena to a minor league contract. |
| Apr 14, 2022 | Signed as free agent | Angel Mata | — | Philadelphia Phillies | Philadelphia Phillies signed free agent C Angel Mata to a minor league contract. |
| Apr 14, 2022 | Signed as free agent | Daniel Camarena | — | San Diego Padres | San Diego Padres signed free agent LHP Daniel Camarena to a minor league contract. |
| Apr 13, 2022 | Trade | Unnamed | Detroit Tigers | Milwaukee Brewers | Milwaukee Brewers traded 2B Jamie Westbrook to Detroit Tigers for cash. |
| Apr 13, 2022 | Released | Daniel Tillo | — | Kansas City Royals | Kansas City Royals released LHP Daniel Tillo. |
| Apr 13, 2022 | Signed as free agent | Elizaul Chalas | — | Chicago Cubs | Chicago Cubs signed free agent 2B Elizaul Chalas to a minor league contract. |
| Apr 13, 2022 | Signed as free agent | Melvyn Amador | — | Chicago Cubs | Chicago Cubs signed free agent LHP Melvyn Amador to a minor league contract. |
| Apr 13, 2022 | Signed as free agent | Wilme Mora | — | Chicago Cubs | Chicago Cubs signed free agent RHP Wilme Mora to a minor league contract. |
| Apr 12, 2022 | Signed as free agent | Jake Elliott | — | Toronto Blue Jays | Toronto Blue Jays signed free agent RHP Jake Elliott to a minor league contract. |
| Apr 12, 2022 | Signed as free agent | Chase Anderson | — | Detroit Tigers | Detroit Tigers signed free agent RHP Chase Anderson to a minor league contract. |
| Apr 12, 2022 | Signed as free agent | Jake Palomaki | — | Los Angeles Angels | Los Angeles Angels signed free agent 2B Jake Palomaki to a minor league contract. |
| Apr 12, 2022 | Signed as free agent | Ofreidy Gómez | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RHP Ofreidy Gomez to a minor league contract. |
| Apr 12, 2022 | Signed as free agent | Garrett Farmer | — | Toronto Blue Jays | Toronto Blue Jays signed free agent RHP Garrett Farmer to a minor league contract. |
| Apr 12, 2022 | Signed as free agent | Joselin Payano | — | Texas Rangers | Texas Rangers signed free agent C Joselin Payano to a minor league contract. |
| Apr 12, 2022 | Signed as free agent | Enyer Burgos | — | Texas Rangers | Texas Rangers signed free agent P Enyer Burgos to a minor league contract. |
| Apr 12, 2022 | Signed as free agent | Jogly García | — | Cleveland Guardians | Cleveland Guardians signed free agent RHP Jogly Garcia to a minor league contract. |
| Apr 12, 2022 | Signed as free agent | Yefris Baptiste | — | Texas Rangers | Texas Rangers signed free agent LHP Yefris Baptiste to a minor league contract. |
| Apr 11, 2022 | Signed as free agent | Ryan Hennen | — | Kansas City Royals | Kansas City Royals signed free agent LHP Ryan Hennen to a minor league contract. |
| Apr 11, 2022 | Signed as free agent | Ben Wereski | — | Kansas City Royals | Kansas City Royals signed free agent LHP Ben Wereski to a minor league contract. |
| Apr 10, 2022 | Signed as free agent | Ti'Quan Forbes | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent 3B Ti'Quan Forbes to a minor league contract. |
| Apr 10, 2022 | Signed as free agent | Roiner Quintana | — | Houston Astros | Houston Astros signed free agent OF Roiner Quintana to a minor league contract. |
| Apr 9, 2022 | Signed as free agent | Preston Tucker | — | Atlanta Braves | Atlanta Braves signed free agent LF Preston Tucker to a minor league contract. |
| Apr 9, 2022 | Signed as free agent | Nick Ramirez | — | Seattle Mariners | Seattle Mariners signed free agent LHP Nick Ramirez to a minor league contract. |
| Apr 9, 2022 | Signed as free agent | Roman Quinn | — | Philadelphia Phillies | Philadelphia Phillies signed free agent CF Roman Quinn to a minor league contract. |
| Apr 9, 2022 | Signed as free agent | Scott Blewett | — | Chicago White Sox | Chicago White Sox signed free agent RHP Scott Blewett to a minor league contract. |
| Apr 9, 2022 | Signed as free agent | Bubba Derby | — | Detroit Tigers | Detroit Tigers signed free agent RHP Bubba Derby to a minor league contract. |
| Apr 9, 2022 | Signed as free agent | Derek Law | — | Detroit Tigers | Detroit Tigers signed free agent RHP Derek Law to a minor league contract. |
| Apr 9, 2022 | Signed as free agent | Tyler Watson | — | Athletics | Oakland Athletics signed free agent LHP Tyler Watson to a minor league contract. |
| Apr 9, 2022 | Signed as free agent | Dawil Almonte | — | Houston Astros | Houston Astros signed free agent RHP Dawill Almonte to a minor league contract. |
| Apr 8, 2022 | Trade | Bradley Zimmer | Cleveland Guardians | Toronto Blue Jays | Cleveland Guardians traded CF Bradley Zimmer to Toronto Blue Jays for RHP Anthony Castro. |
| Apr 8, 2022 | Signed as free agent | Matt Harvey | — | Baltimore Orioles | Baltimore Orioles signed free agent RHP Matt Harvey to a minor league contract. |
| Apr 8, 2022 | Signed as free agent | Delino DeShields | — | Atlanta Braves | Atlanta Braves signed free agent CF Delino DeShields to a minor league contract. |
| Apr 8, 2022 | Released | Justin Upton | — | Los Angeles Angels | Los Angeles Angels released LF Justin Upton. |
| Apr 8, 2022 | Signed as free agent | Johnny Cueto | — | Chicago White Sox | Chicago White Sox signed free agent RHP Johnny Cueto to a minor league contract. |
| Apr 8, 2022 | Signed as free agent | Lennyn Nunez | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent C Lennyn Nunez to a minor league contract. |
| Apr 7, 2022 | Signed as free agent | Chance Sisco | — | Minnesota Twins | Minnesota Twins signed free agent C Chance Sisco to a minor league contract. |
| Apr 7, 2022 | Trade | Taylor Rogers | Minnesota Twins | San Diego Padres | San Diego Padres traded RHP Chris Paddack, RHP Emilio Pagan and Player To Be Named Later to Minnesota Twins for LHP Taylor Rogers, OF Brent Rooker and cash. |
| Apr 7, 2022 | Signed as free agent | Jake Marisnick | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent CF Jake Marisnick. |
| Apr 7, 2022 | Signed as free agent | Kyle Crick | — | Chicago White Sox | Chicago White Sox signed free agent RHP Kyle Crick. |
| Apr 7, 2022 | Trade | Jeferson Espinal | Arizona Diamondbacks | Texas Rangers | Arizona Diamondbacks traded CF Jeferson Espinal to Texas Rangers for 2B Yonny Hernandez. |
| Apr 7, 2022 | Trade | Hayden Cantrelle | Milwaukee Brewers | Miami Marlins | Miami Marlins traded C Alex Jackson to Milwaukee Brewers for SS Hayden Cantrelle. |
| Apr 7, 2022 | Signed as free agent | Keegan Fish | — | Chicago White Sox | Chicago White Sox signed free agent C Keegan Fish to a minor league contract. |
| Apr 7, 2022 | Signed as free agent | Jason Matthews | — | Chicago White Sox | Chicago White Sox signed free agent SS Jason Matthews to a minor league contract. |
| Apr 7, 2022 | Trade | Adonis Medina | Pittsburgh Pirates | New York Mets | Pittsburgh Pirates traded RHP Adonis Medina to New York Mets. |
| Apr 7, 2022 | Trade | Mason McCoy | Baltimore Orioles | Seattle Mariners | Baltimore Orioles traded SS Mason McCoy to Seattle Mariners. |
| Apr 7, 2022 | Signed as free agent | Ross Detwiler | — | Cincinnati Reds | Cincinnati Reds signed free agent LHP Ross Detwiler to a minor league contract. |
| Apr 7, 2022 | Signed as free agent | Dellin Betances | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Dellin Betances to a minor league contract. |
| Apr 7, 2022 | Signed | Austin Ross | — | Philadelphia Phillies | Philadelphia Phillies signed RHP Austin Ross. |
| Apr 7, 2022 | Signed as free agent | Maicor Serrano | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Maicor Serrano to a minor league contract. |
| Apr 7, 2022 | Signed as free agent | Adrian Garcia | — | Seattle Mariners | Seattle Mariners signed free agent C Adrian Garcia to a minor league contract. |
| Apr 6, 2022 | Signed as free agent | Chase Barbary | — | Detroit Tigers | Detroit Tigers signed free agent C Chase Barbary to a minor league contract. |
| Apr 6, 2022 | Signed as free agent | Rob Kaminsky | — | Seattle Mariners | Seattle Mariners signed free agent LHP Rob Kaminsky. |
| Apr 6, 2022 | Signed as free agent | Taylor Featherston | — | Seattle Mariners | Seattle Mariners signed free agent 3B Taylor Featherston to a minor league contract. |
| Apr 6, 2022 | Signed as free agent | John Curtiss | — | New York Mets | New York Mets signed free agent RHP John Curtiss. |
| Apr 6, 2022 | Signed as free agent | Greg Bird | — | New York Yankees | New York Yankees signed free agent 1B Greg Bird to a minor league contract. |
| Apr 6, 2022 | Trade | Victor Caratini | San Diego Padres | Milwaukee Brewers | San Diego Padres traded C Victor Caratini to Milwaukee Brewers for C Brett Sullivan and SS Korry Howell. |
| Apr 6, 2022 | Signed as free agent | Andrew Knapp | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent C Andrew Knapp. |
| Apr 6, 2022 | Signed as free agent | Jesus Cruz | — | Atlanta Braves | Atlanta Braves signed free agent RHP Jesus Cruz to a minor league contract. |
| Apr 6, 2022 | Signed as free agent | Chariel Radney | — | Tampa Bay Rays | Tampa Bay Rays signed free agent LHP Chariel Radney to a minor league contract. |
| Apr 5, 2022 | Trade | Austin Meadows | Tampa Bay Rays | Detroit Tigers | Detroit Tigers traded SS Isaac Paredes to Tampa Bay Rays for LF Austin Meadows. |
| Apr 5, 2022 | Released | Shogo Akiyama | — | Cincinnati Reds | Cincinnati Reds released OF Shogo Akiyama. |
| Apr 5, 2022 | Signed as free agent | Adrian Acosta | — | Los Angeles Angels | Los Angeles Angels signed free agent RHP Adrian Acosta to a minor league contract. |
| Apr 5, 2022 | Signed as free agent | Shea Spitzbarth | — | Detroit Tigers | Detroit Tigers signed free agent RHP Shea Spitzbarth to a minor league contract. |
| Apr 5, 2022 | Signed as free agent | Jose Garcia | — | Miami Marlins | Miami Marlins signed free agent C Jose Garcia to a minor league contract. |
| Apr 5, 2022 | Signed as free agent | Manuel Rodriguez | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Manuel Rodriguez to a minor league contract. |
| Apr 4, 2022 | Trade | David McKay | Tampa Bay Rays | New York Yankees | Tampa Bay Rays traded RHP David McKay to New York Yankees for cash. |
| Apr 4, 2022 | Signed as free agent | Austin Warner | — | Seattle Mariners | Seattle Mariners signed free agent LHP Austin Warner to a minor league contract. |
| Apr 4, 2022 | Released | Elijah Greene | — | Minnesota Twins | Minnesota Twins released OF Elijah Greene. |
| Apr 4, 2022 | Released | Anderson Tejeda | — | St. Louis Cardinals | St. Louis Cardinals released SS Anderson Tejeda. |
| Apr 4, 2022 | Signed as free agent | Monte Harrison | — | Los Angeles Angels | Los Angeles Angels signed free agent CF Monte Harrison to a minor league contract. |
| Apr 4, 2022 | Signed as free agent | Derek Dietrich | — | New York Yankees | New York Yankees signed free agent 2B Derek Dietrich to a minor league contract. |
| Apr 4, 2022 | Signed as free agent | Nathan Perry | — | Tampa Bay Rays | Tampa Bay Rays signed free agent C Nathan Perry to a minor league contract. |
| Apr 3, 2022 | Trade | Euribiel Angeles | San Diego Padres | Athletics | Oakland Athletics traded LHP Sean Manaea and RHP Aaron Holiday to San Diego Padres for RHP Adrian Martinez and 2B Euribiel Angeles. |
| Apr 3, 2022 | Trade | Joely Rodríguez | New York Yankees | New York Mets | New York Mets traded RHP Miguel Castro to New York Yankees for LHP Joely Rodriguez. |
| Apr 3, 2022 | Trade | Reese McGuire | Toronto Blue Jays | Chicago White Sox | Toronto Blue Jays traded C Reese McGuire to Chicago White Sox for C Zack Collins. |
| Apr 3, 2022 | Trade | Kevin Guerrero | Miami Marlins | Baltimore Orioles | Baltimore Orioles traded RHP Cole Sulser and LHP Tanner Scott to Miami Marlins for OF Kevin Guerrero and LHP Antonio Velez. |
| Apr 3, 2022 | Released | Joel Booker | — | Chicago White Sox | Chicago White Sox released CF Joel Booker. |
| Apr 3, 2022 | Released | Jake Elliott | — | Chicago White Sox | Chicago White Sox released RHP Jake Elliott. |
| Apr 3, 2022 | Released | Andrew Knapp | — | Cincinnati Reds | Cincinnati Reds released C Andrew Knapp. |
| Apr 3, 2022 | Released | Daniel Ponce de Leon | — | Los Angeles Angels | Los Angeles Angels released RHP Daniel Ponce de Leon. |
| Apr 3, 2022 | Signed as free agent | Ryan Burrowes | — | Chicago White Sox | Chicago White Sox signed free agent SS Ryan Burrowes to a minor league contract. |
| Apr 3, 2022 | Signed as free agent | Trey Cumbie | — | Toronto Blue Jays | Toronto Blue Jays signed free agent LHP Trey Cumbie to a minor league contract. |
| Apr 2, 2022 | Signed as free agent | Connor Jones | — | Seattle Mariners | Seattle Mariners signed free agent RHP Connor Jones to a minor league contract. |
| Apr 2, 2022 | Signed as free agent | Joshua Fuentes | — | Toronto Blue Jays | Toronto Blue Jays signed free agent 3B Joshua Fuentes to a minor league contract. |
| Apr 2, 2022 | Trade | Jose Trevino | Texas Rangers | New York Yankees | Texas Rangers traded C Jose Trevino to New York Yankees for RHP Albert Abreu and LHP Robert Ahlstrom. |
| Apr 2, 2022 | Released | Chance Sisco | — | Seattle Mariners | Seattle Mariners released C Chance Sisco. |
| Apr 1, 2022 | Trade | Josh VanMeter | Arizona Diamondbacks | Pittsburgh Pirates | Arizona Diamondbacks traded 2B Josh VanMeter to Pittsburgh Pirates for RHP Listher Sosa. |
| Apr 1, 2022 | Trade | AJ Pollock | Los Angeles Dodgers | Chicago White Sox | Chicago White Sox traded RHP Craig Kimbrel to Los Angeles Dodgers for CF AJ Pollock. |
| Apr 1, 2022 | Released | Renae Martinez | — | Arizona Diamondbacks | Arizona Diamondbacks released C Renae Martinez. |
| Apr 1, 2022 | Signed as free agent | R.J. Freure | — | Atlanta Braves | Atlanta Braves signed free agent RHP R.J. Freure to a minor league contract. |
| Apr 1, 2022 | Released | Bernardo Flores Jr. | — | Colorado Rockies | Colorado Rockies released LHP Bernardo Flores Jr.. |
| Apr 1, 2022 | Signed as free agent | Jose Rodulfo | — | Chicago White Sox | Chicago White Sox signed free agent RHP Jose Rodulfo to a minor league contract. |
| Apr 1, 2022 | Released | Ethan Paul | — | Pittsburgh Pirates | Pittsburgh Pirates released SS Ethan Paul. |
| Apr 1, 2022 | Signed as free agent | Ricardo Sánchez | — | Philadelphia Phillies | Philadelphia Phillies signed free agent LHP Ricardo Sanchez to a minor league contract. |
| Apr 1, 2022 | Signed as free agent | Mike Mokma | — | Seattle Mariners | Seattle Mariners signed free agent RHP Mike Mokma to a minor league contract. |
| Apr 1, 2022 | Released | Connor Hollis | — | Tampa Bay Rays | Tampa Bay Rays released 2B Connor Hollis. |
| Apr 1, 2022 | Signed as free agent | Connor Hollis | — | San Diego Padres | San Diego Padres signed free agent 2B Connor Hollis to a minor league contract. |
| Apr 1, 2022 | Signed as free agent | Bernardo Flores Jr. | — | Cincinnati Reds | Cincinnati Reds signed free agent LHP Bernardo Flores Jr. to a minor league contract. |
| Apr 1, 2022 | Signed as free agent | Amauri Otero | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent LHP Amauri Otero to a minor league contract. |
| Apr 1, 2022 | Signed as free agent | Yadiel Rivera | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent SS Yadiel Rivera to a minor league contract. |
| Apr 1, 2022 | Signed as free agent | Geraldo Cabrera | — | Houston Astros | Houston Astros signed free agent RHP Geraldo Cabrera to a minor league contract. |
| Apr 1, 2022 | Signed as free agent | Riskiel Tineo | — | Miami Marlins | Miami Marlins signed free agent RHP Riskiel Tineo to a minor league contract. |
| Mar 31, 2022 | Signed as free agent | Unnamed | — | Toronto Blue Jays | Toronto Blue Jays signed free agent CF Dexter Fowler and to a minor league contract and invited him to spring training. |
| Mar 31, 2022 | Signed as free agent | Tyler Clippard | — | Washington Nationals | Washington Nationals signed free agent RHP Tyler Clippard and to a minor league contract. |
| Mar 31, 2022 | Released | Brock Holt | — | Atlanta Braves | Atlanta Braves released 2B Brock Holt. |
| Mar 31, 2022 | Released | Ryon Healy | — | Tampa Bay Rays | Tampa Bay Rays released 1B Ryon Healy. |
| Mar 31, 2022 | Signed as free agent | Unnamed | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent 2B Jordan Howard and to a minor league contract. |
| Mar 31, 2022 | Released | Sandy León | — | Cleveland Guardians | Cleveland Guardians released C Sandy Leon. |
| Mar 31, 2022 | Released | Chris Proctor | — | Detroit Tigers | Detroit Tigers released C Christopher Proctor. |
| Mar 31, 2022 | Released | Ryan Buchter | — | Seattle Mariners | Seattle Mariners released LHP Ryan Buchter. |
| Mar 31, 2022 | Released | Austin Warner | — | St. Louis Cardinals | St. Louis Cardinals released LHP Austin Warner. |
| Mar 31, 2022 | Signed as free agent | Mike Pascoe | — | Miami Marlins | Miami Marlins signed free agent RHP Mike Pascoe to a minor league contract. |
| Mar 30, 2022 | Trade | Unnamed | Philadelphia Phillies | San Diego Padres | Philadelphia Phillies traded SS Kervin Pichardo and cash to San Diego Padres for RHP James Norwood. |
| Mar 30, 2022 | Signed as free agent | John Creel | — | Seattle Mariners | Seattle Mariners signed free agent RHP John Creel to a minor league contract. |
| Mar 30, 2022 | Signed as free agent | Seth Elledge | — | Atlanta Braves | Atlanta Braves signed free agent RHP Seth Elledge and to a minor league contract. |
| Mar 30, 2022 | Signed as free agent | Brian Klein | — | Atlanta Braves | Atlanta Braves signed free agent 2B Brian Klein to a minor league contract. |
| Mar 30, 2022 | Signed as free agent | Dan Altavilla | — | Boston Red Sox | Boston Red Sox signed free agent RHP Dan Altavilla. |
| Mar 30, 2022 | Signed as free agent | Joe Deluca | — | Cincinnati Reds | Cincinnati Reds signed free agent C Joe Deluca to a minor league contract. |
| Mar 30, 2022 | Signed as free agent | Brandon Jenkins | — | Colorado Rockies | Colorado Rockies signed free agent RHP Brandon Jenkins to a minor league contract. |
| Mar 30, 2022 | Signed as free agent | Quincy Nieporte | — | Detroit Tigers | Detroit Tigers signed free agent 1B Quincy Nieporte to a minor league contract. |
| Mar 30, 2022 | Signed as free agent | Justin Friedman | — | Kansas City Royals | Kansas City Royals signed free agent RHP Justin Friedman to a minor league contract. |
| Mar 30, 2022 | Released | Denny Brady | — | Los Angeles Angels | Los Angeles Angels released RHP Denny Brady. |
| Mar 30, 2022 | Signed as free agent | Wander Suero | — | Los Angeles Angels | Los Angeles Angels signed free agent RHP Wander Suero to a minor league contract. |
| Mar 30, 2022 | Signed as free agent | Tyler Herb | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Tyler Herb to a minor league contract. |
| Mar 30, 2022 | Signed as free agent | Tyler Bashlor | — | Minnesota Twins | Minnesota Twins signed free agent RHP Tyler Bashlor to a minor league contract. |
| Mar 30, 2022 | Released | Jimmy Kerrigan | — | Minnesota Twins | Minnesota Twins released OF Jimmy Kerrigan. |
| Mar 30, 2022 | Signed as free agent | Jake Petricka | — | Minnesota Twins | Minnesota Twins signed free agent RHP Jake Petricka to a minor league contract. |
| Mar 30, 2022 | Signed as free agent | JC Ramírez | — | Minnesota Twins | Minnesota Twins signed free agent RHP JC Ramirez to a minor league contract. |
| Mar 30, 2022 | Signed as free agent | José Mujica | — | New York Yankees | New York Yankees signed free agent RHP Jose Mujica to a minor league contract. |
| Mar 30, 2022 | Signed as free agent | Jorge Bonifacio | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RF Jorge Bonifacio to a minor league contract. |
| Mar 30, 2022 | Signed as free agent | Michael Mariot | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RHP Michael Mariot to a minor league contract. |
| Mar 30, 2022 | Released | Jesus Cruz | — | St. Louis Cardinals | St. Louis Cardinals released RHP Jesus Cruz. |
| Mar 30, 2022 | Released | Carl Chester | — | Texas Rangers | Texas Rangers released OF Carl Chester. |
| Mar 30, 2022 | Signed as free agent | Jamie Johnson | — | Seattle Mariners | Seattle Mariners signed free agent C Jamie Johnson to a minor league contract. |
| Mar 30, 2022 | Signed as free agent | Myles Miller | — | Seattle Mariners | Seattle Mariners signed free agent OF Myles Miller to a minor league contract. |
| Mar 29, 2022 | Trade | Unnamed | — | Philadelphia Phillies | Philadelphia Phillies traded CF Adam Haseley to Chicago White Sox for RHP McKinley Moore and. |
| Mar 29, 2022 | Trade | Connor Phillips | Seattle Mariners | Cincinnati Reds | Seattle Mariners traded RHP Connor Phillips to Cincinnati Reds. |
| Mar 29, 2022 | Signed as free agent | Evelio Hernandez | — | Cleveland Guardians | Cleveland Guardians signed free agent RHP Evelio Hernandez to a minor league contract. |
| Mar 29, 2022 | Signed as free agent | José Ureña | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Jose Urena to a minor league contract. |
| Mar 29, 2022 | Signed as free agent | Keine Urdaneta | — | Kansas City Royals | Kansas City Royals signed free agent SS Keine Urdaneta to a minor league contract. |
| Mar 29, 2022 | Signed as free agent | Eric Dominguez | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent LHP Eric Dominguez to a minor league contract. |
| Mar 28, 2022 | Trade | River Ryan | San Diego Padres | Los Angeles Dodgers | Los Angeles Dodgers traded 1B Matt Beaty to San Diego Padres for RHP River Ryan. |
| Mar 28, 2022 | Signed as free agent | Chris Archer | — | Minnesota Twins | Minnesota Twins signed free agent RHP Chris Archer. |
| Mar 28, 2022 | Signed as free agent | Carlos Mateo | — | Houston Astros | Houston Astros signed free agent RHP Carlos Mateo to a minor league contract. |
| Mar 28, 2022 | Signed as free agent | Jose Ramirez | — | Cleveland Guardians | Cleveland Guardians signed free agent RHP Jose Ramirez to a minor league contract. |
| Mar 28, 2022 | Signed as free agent | Yaisel Ramos | — | St. Louis Cardinals | St. Louis Cardinals signed free agent CF Yaisel Ramos to a minor league contract. |
| Mar 28, 2022 | Signed as free agent | Ruben De La Cruz | — | Boston Red Sox | Boston Red Sox signed free agent RHP Ruben De La Cruz to a minor league contract. |
| Mar 28, 2022 | Signed as free agent | Sandy Martinez | — | Washington Nationals | Washington Nationals signed free agent RHP Sandy Martinez to a minor league contract. |
| Mar 28, 2022 | Signed as free agent | Albert Pujols | — | St. Louis Cardinals | St. Louis Cardinals signed free agent 1B Albert Pujols. |
| Mar 27, 2022 | Signed as free agent | Shelby Miller | — | New York Yankees | New York Yankees signed free agent RHP Shelby Miller to a minor league contract and invited him to spring training. |
| Mar 27, 2022 | Trade | Sergio Alcántara | Chicago Cubs | Arizona Diamondbacks | Chicago Cubs traded SS Sergio Alcantara to Arizona Diamondbacks for cash. |
| Mar 27, 2022 | Trade | Unnamed | San Francisco Giants | Philadelphia Phillies | San Francisco Giants traded 3B Will Toffey and cash to Philadelphia Phillies for 3B Luke Williams. |
| Mar 27, 2022 | Trade | Unnamed | — | Miami Marlins | Houston Astros traded OF Norel Gonzalez and to Miami Marlins. |
| Mar 26, 2022 | Signed as free agent | Blake Parker | — | St. Louis Cardinals | St. Louis Cardinals signed free agent RHP Blake Parker to a minor league contract and invited him to spring training. |
| Mar 26, 2022 | Signed as free agent | Unnamed | — | Cincinnati Reds | Cincinnati Reds signed free agent CF Tommy Pham, and. |
| Mar 26, 2022 | Signed as free agent | Jed Lowrie | — | Athletics | Oakland Athletics signed free agent SS Jed Lowrie. |
| Mar 26, 2022 | Signed as free agent | Kendeglys Virguez | — | Cleveland Guardians | Cleveland Guardians signed free agent RHP Kendeglys Virguez to a minor league contract. |
| Mar 26, 2022 | Signed as free agent | Erick Padilla | — | Cleveland Guardians | Cleveland Guardians signed free agent RHP Erick Padilla to a minor league contract. |
| Mar 26, 2022 | Signed as free agent | Franklin Bolivar | — | Cleveland Guardians | Cleveland Guardians signed free agent RHP Franklin Bolivar to a minor league contract. |
| Mar 26, 2022 | Signed as free agent | Neiver Acosta | — | Cleveland Guardians | Cleveland Guardians signed free agent RHP Neiver Acosta to a minor league contract. |
| Mar 25, 2022 | Signed as free agent | Bryan Shaw | — | Cleveland Guardians | Cleveland Guardians signed free agent RHP Bryan Shaw, and. |
| Mar 25, 2022 | Signed as free agent | Cory Spangenberg | — | St. Louis Cardinals | St. Louis Cardinals signed free agent 2B Cory Spangenberg to a minor league contract and invited him to spring training. |
| Mar 25, 2022 | Trade | Harold Ramírez | Chicago Cubs | Tampa Bay Rays | Chicago Cubs traded RF Harold Ramirez to Tampa Bay Rays for 3B Esteban Quiroz. |
| Mar 25, 2022 | Signed as free agent | David Dominguez | — | Milwaukee Brewers | Milwaukee Brewers signed free agent LHP David Dominguez to a minor league contract. |
| Mar 25, 2022 | Signed as free agent | Aneuris Rodriguez | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Aneuris Rodriguez to a minor league contract. |
| Mar 25, 2022 | Signed as free agent | Franddy De Los Santos | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Franddy De Los Santos to a minor league contract. |
| Mar 25, 2022 | Signed as free agent | Franddy De Los Santos | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Franddy De Los Santos to a minor league contract. |
| Mar 24, 2022 | Signed as free agent | Luke Bard | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP Luke Bard, , and to a minor league contract and invited him to spring training. |
| Mar 24, 2022 | Signed as free agent | Kevin Pillar | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent CF Kevin Pillar to a minor league contract. |
| Mar 24, 2022 | Signed as free agent | Sergio Romo | — | Seattle Mariners | Seattle Mariners signed free agent RHP Sergio Romo. |
| Mar 24, 2022 | Trade | Raimel Tapia | Colorado Rockies | Toronto Blue Jays | Colorado Rockies traded RF Raimel Tapia and 2B Adrian Pinto to Toronto Blue Jays for RF Randal Grichuk and cash. |
| Mar 24, 2022 | Signed as free agent | Unnamed | — | Houston Astros | Houston Astros signed free agent 2B Franklin Barreto and to a minor league contract and invited him to spring training. |
| Mar 24, 2022 | Signed as free agent | Stephen Vogt | — | Athletics | Oakland Athletics signed free agent C Stephen Vogt. |
| Mar 24, 2022 | Signed as free agent | Riggs Threadgill | — | Washington Nationals | Washington Nationals signed free agent RHP Riggs Threadgill to a minor league contract. |
| Mar 23, 2022 | Signed as free agent | Trevor Story | — | Boston Red Sox | Boston Red Sox signed free agent SS Trevor Story. |
| Mar 23, 2022 | Signed as free agent | Unnamed | — | Chicago Cubs | Chicago Cubs signed free agent RHP Mychal Givens, and. |
| Mar 23, 2022 | Signed as free agent | Unnamed | — | Cincinnati Reds | Cincinnati Reds signed free agent RHP Hunter Strickland, and. |
| Mar 23, 2022 | Signed as free agent | Hanser Alberto | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent 2B Hanser Alberto. |
| Mar 23, 2022 | Signed as free agent | Zach Davies | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Zach Davies. |
| Mar 22, 2022 | Signed as free agent | Jorge Soler | — | Miami Marlins | Miami Marlins signed free agent RF Jorge Soler. |
| Mar 22, 2022 | Signed as free agent | Unnamed | — | Tampa Bay Rays | Tampa Bay Rays signed free agent 1B Ryon Healy, and to a minor league contract and invited him to spring training. |
| Mar 22, 2022 | Signed as free agent | Carlos Correa | — | Minnesota Twins | Minnesota Twins signed free agent SS Carlos Correa. |
| Mar 22, 2022 | Signed as free agent | Charlie Culberson | — | Texas Rangers | Texas Rangers signed free agent 3B Charlie Culberson to a minor league contract. |
| Mar 22, 2022 | Signed as free agent | Adam Morgan | — | Houston Astros | Houston Astros signed free agent LHP Adam Morgan and to a minor league contract and invited him to spring training. |
| Mar 22, 2022 | Signed as free agent | Sal Romano | — | Seattle Mariners | Seattle Mariners signed free agent RHP Sal Romano and to a minor league contract and invited him to spring training. |
| Mar 22, 2022 | Signed as free agent | Unnamed | — | Philadelphia Phillies | Philadelphia Phillies signed free agent 3B Nick Castellanos, and. |
| Mar 22, 2022 | Signed as free agent | Steven Brault | — | Chicago Cubs | Chicago Cubs signed free agent LHP Steven Brault and to a minor league contract. |
| Mar 22, 2022 | Signed as free agent | Josue Arias | — | Miami Marlins | Miami Marlins signed free agent LHP Josue Arias to a minor league contract. |
| Mar 21, 2022 | Signed as free agent | Zach Messinger | — | New York Yankees | New York Yankees signed free agent RHP Zach Messinger to a minor league contract. |
| Mar 21, 2022 | Signed as free agent | Billy Hamilton | — | Seattle Mariners | Seattle Mariners signed free agent CF Billy Hamilton and to a minor league contract and invited him to spring training. |
| Mar 21, 2022 | Signed as free agent | Robert Gsellman | — | Chicago Cubs | Chicago Cubs signed free agent RHP Robert Gsellman and to a minor league contract and invited him to spring training. |
| Mar 21, 2022 | Signed as free agent | Oliver Pérez | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent LHP Oliver Perez to a minor league contract and invited him to spring training. |
| Mar 21, 2022 | Signed as free agent | Marwin Gonzalez | — | New York Yankees | New York Yankees signed free agent SS Marwin Gonzalez to a minor league contract and invited him to spring training. |
| Mar 21, 2022 | Signed as free agent | Unnamed | — | Cincinnati Reds | Cincinnati Reds signed free agent 2B Brandon Drury and to a minor league contract and invited him to spring training. |
| Mar 21, 2022 | Signed as free agent | Kyle Zimmer | — | Cincinnati Reds | Cincinnati Reds signed free agent RHP Kyle Zimmer to a minor league contract and invited him to spring training. |
| Mar 21, 2022 | Signed as free agent | Ryan Meisinger | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Ryan Meisinger to a minor league contract. |
| Mar 21, 2022 | Signed as free agent | Liz Sanchez | — | Houston Astros | Houston Astros signed free agent LHP Liz Sanchez to a minor league contract. |
| Mar 21, 2022 | Signed as free agent | Euris Vasquez | — | Houston Astros | Houston Astros signed free agent RHP Euris Vasquez to a minor league contract. |
| Mar 20, 2022 | Signed as free agent | Matt Carpenter | — | Texas Rangers | Texas Rangers signed free agent 3B Matt Carpenter to a minor league contract and invited him to spring training. |
| Mar 20, 2022 | Signed as free agent | R.J. Alaniz | — | Atlanta Braves | Atlanta Braves signed free agent RHP R.J. Alaniz to a minor league contract. |
| Mar 20, 2022 | Signed as free agent | Robel García | — | Chicago Cubs | Chicago Cubs signed free agent 2B Robel Garcia to a minor league contract and invited him to spring training. |
| Mar 20, 2022 | Signed as free agent | Brock Holt | — | Atlanta Braves | Atlanta Braves signed free agent 2B Brock Holt to a minor league contract and invited him to spring training. |
| Mar 20, 2022 | Signed as free agent | Joe Smith | — | Minnesota Twins | Minnesota Twins signed free agent RHP Joe Smith. |
| Mar 20, 2022 | Signed as free agent | Billy McKinney | — | Athletics | Oakland Athletics signed free agent LF Billy McKinney to a minor league contract. |
| Mar 20, 2022 | Signed as free agent | Matthew Boyd | — | San Francisco Giants | San Francisco Giants signed free agent LHP Matthew Boyd. |
| Mar 20, 2022 | Signed as free agent | Donovan Solano | — | Cincinnati Reds | Cincinnati Reds signed free agent 2B Donovan Solano. |
| Mar 20, 2022 | Signed as free agent | Unnamed | — | Philadelphia Phillies | Philadelphia Phillies signed free agent LF Kyle Schwarber, and. |
| Mar 20, 2022 | Signed as free agent | Ryan Buchter | — | Seattle Mariners | Seattle Mariners signed free agent LHP Ryan Buchter to a minor league contract and invited him to spring training. |
| Mar 20, 2022 | Signed as free agent | Albert Almora Jr. | — | Cincinnati Reds | Cincinnati Reds signed free agent CF Albert Almora Jr. and to a minor league contract and invited him to spring training. |
| Mar 20, 2022 | Signed as free agent | Chi Chi González | — | Minnesota Twins | Minnesota Twins signed free agent RHP Chi Chi Gonzalez to a minor league contract and invited him to spring training. |
| Mar 20, 2022 | Signed as free agent | Garrett Richards | — | Texas Rangers | Texas Rangers signed free agent RHP Garrett Richards. |
| Mar 20, 2022 | Signed as free agent | Nash Knight | — | Texas Rangers | Texas Rangers signed free agent 2B Nash Knight to a minor league contract. |
| Mar 20, 2022 | Signed as free agent | Ariel Jurado | — | Minnesota Twins | Minnesota Twins signed free agent RHP Ariel Jurado to a minor league contract. |
| Mar 20, 2022 | Signed as free agent | Tyler Viza | — | Minnesota Twins | Minnesota Twins signed free agent RHP Tyler Viza to a minor league contract. |
| Mar 20, 2022 | Signed as free agent | Thomas Eshelman | — | San Diego Padres | San Diego Padres signed free agent RHP Thomas Eshelman to a minor league contract. |
| Mar 20, 2022 | Signed as free agent | Robert Dugger | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP Robert Dugger to a minor league contract. |
| Mar 19, 2022 | Signed as free agent | Kenley Jansen | — | Atlanta Braves | Atlanta Braves signed free agent RHP Kenley Jansen. |
| Mar 19, 2022 | Signed as free agent | Unnamed | — | San Diego Padres | San Diego Padres signed free agent RHP Nick Martinez, and. |
| Mar 19, 2022 | Signed as free agent | Michael Pineda | — | Detroit Tigers | Detroit Tigers signed free agent RHP Michael Pineda. |
| Mar 19, 2022 | Signed as free agent | Ryan Tepera | — | Los Angeles Angels | Los Angeles Angels signed free agent RHP Ryan Tepera. |
| Mar 19, 2022 | Signed as free agent | Jonathan Villar | — | Chicago Cubs | Chicago Cubs signed free agent SS Jonathan Villar. |
| Mar 19, 2022 | Signed as free agent | Drew Smyly | — | Chicago Cubs | Chicago Cubs signed free agent LHP Drew Smyly. |
| Mar 19, 2022 | Signed as free agent | Daniel Norris | — | Chicago Cubs | Chicago Cubs signed free agent LHP Daniel Norris. |
| Mar 19, 2022 | Signed as free agent | Hansel Robles | — | Boston Red Sox | Boston Red Sox signed free agent RHP Hansel Robles to a minor league contract and invited him to spring training. |
| Mar 19, 2022 | Signed as free agent | Adrian Sampson | — | Chicago Cubs | Chicago Cubs signed free agent RHP Adrian Sampson to a minor league contract and invited him to spring training. |
| Mar 19, 2022 | Signed as free agent | Zac Rosscup | — | Houston Astros | Houston Astros signed free agent LHP Zac Rosscup to a minor league contract. |
| Mar 19, 2022 | Signed as free agent | Mitchell Tolman | — | Cleveland Guardians | Cleveland Guardians signed free agent 2B Mitchell Tolman to a minor league contract. |
| Mar 19, 2022 | Signed as free agent | Jake Kalish | — | Los Angeles Angels | Los Angeles Angels signed free agent LHP Jake Kalish and to a minor league contract. |
| Mar 19, 2022 | Signed as free agent | Mike Montgomery | — | New York Mets | New York Mets signed free agent LHP Mike Montgomery and to a minor league contract. |
| Mar 19, 2022 | Signed as free agent | Brad Brach | — | Atlanta Braves | Atlanta Braves signed free agent RHP Brad Brach to a minor league contract and invited him to spring training. |
| Mar 19, 2022 | Signed as free agent | Phil Gosselin | — | Atlanta Braves | Atlanta Braves signed free agent 2B Phil Gosselin to a minor league contract and invited him to spring training. |
| Mar 19, 2022 | Signed as free agent | Sam McWilliams | — | Cincinnati Reds | Cincinnati Reds signed free agent RHP Sam McWilliams to a minor league contract. |
| Mar 19, 2022 | Signed as free agent | Ronald Torreyes | — | Philadelphia Phillies | Philadelphia Phillies signed free agent SS Ronald Torreyes to a minor league contract. |
| Mar 19, 2022 | Signed as free agent | Austin Wynns | — | Philadelphia Phillies | Philadelphia Phillies signed free agent C Austin Wynns to a minor league contract. |
| Mar 19, 2022 | Signed as free agent | Taylor Williams | — | San Francisco Giants | San Francisco Giants signed free agent RHP Taylor Williams to a minor league contract. |
| Mar 19, 2022 | Signed as free agent | Unnamed | — | San Francisco Giants | San Francisco Giants signed free agent RHP Carlos Martinez and to a minor league contract. |
| Mar 18, 2022 | Signed as free agent | Beau Taylor | — | Baltimore Orioles | Baltimore Orioles signed free agent C Beau Taylor to a minor league contract and invited him to spring training. |
| Mar 18, 2022 | Trade | Luke Voit | New York Yankees | San Diego Padres | New York Yankees traded 1B Luke Voit to San Diego Padres for RHP Justin Lange. |
| Mar 18, 2022 | Signed as free agent | Kris Bryant | — | Colorado Rockies | Colorado Rockies signed free agent 3B Kris Bryant. |
| Mar 18, 2022 | Signed as free agent | Corey Dickerson | — | St. Louis Cardinals | St. Louis Cardinals signed free agent LF Corey Dickerson. |
| Mar 18, 2022 | Signed as free agent | Archie Bradley | — | Los Angeles Angels | Los Angeles Angels signed free agent RHP Archie Bradley. |
| Mar 18, 2022 | Signed as free agent | Seiya Suzuki | — | Chicago Cubs | Chicago Cubs signed free agent OF Seiya Suzuki. |
| Mar 18, 2022 | Signed as free agent | Freddie Freeman | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent 1B Freddie Freeman. |
| Mar 18, 2022 | Signed as free agent | Jake Lamb | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent 3B Jake Lamb and to a minor league contract and invited him to spring training. |
| Mar 18, 2022 | Trade | Tanner Dodson | Tampa Bay Rays | Los Angeles Dodgers | Los Angeles Dodgers traded LF Luke Raley to Tampa Bay Rays for RHP Tanner Dodson. |
| Mar 18, 2022 | Signed as free agent | Tyler Anderson | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent LHP Tyler Anderson to a minor league contract. |
| Mar 18, 2022 | Signed as free agent | Tyler Anderson | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent LHP Tyler Anderson. |
| Mar 18, 2022 | Signed as free agent | Travis Bergen | — | San Diego Padres | San Diego Padres signed free agent LHP Travis Bergen to a minor league contract. |
| Mar 18, 2022 | Signed as free agent | Delino DeShields | — | Miami Marlins | Miami Marlins signed free agent CF Delino DeShields to a minor league contract. |
| Mar 18, 2022 | Signed as free agent | Danny Duffy | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent LHP Danny Duffy. |
| Mar 18, 2022 | Signed as free agent | Pat Valaika | — | Atlanta Braves | Atlanta Braves signed free agent SS Pat Valaika to a minor league contract and invited him to spring training. |
| Mar 18, 2022 | Signed as free agent | Brandon Dixon | — | San Diego Padres | San Diego Padres signed free agent 3B Brandon Dixon to a minor league contract. |
| Mar 18, 2022 | Signed as free agent | Ian Krol | — | San Diego Padres | San Diego Padres signed free agent LHP Ian Krol to a minor league contract. |
| Mar 18, 2022 | Signed as free agent | Donal Montas | — | Detroit Tigers | Detroit Tigers signed free agent RHP Donal Montas to a minor league contract. |
| Mar 18, 2022 | Signed as free agent | German Nunez | — | Texas Rangers | Texas Rangers signed free agent RHP German Nunez to a minor league contract. |
| Mar 18, 2022 | Signed as free agent | Liomar Martinez | — | Miami Marlins | Miami Marlins signed free agent RHP Liomar Martinez to a minor league contract. |
| Mar 18, 2022 | Signed as free agent | Juan Peralta | — | Texas Rangers | Texas Rangers signed free agent LHP Juan Peralta to a minor league contract. |
| Mar 18, 2022 | Signed as free agent | Julio Henriquez | — | Miami Marlins | Miami Marlins signed free agent OF Julio Henriquez to a minor league contract. |
| Mar 18, 2022 | Signed as free agent | Anthony Narvaez | — | Minnesota Twins | Minnesota Twins signed free agent RHP Anthony Narvaez to a minor league contract. |
| Mar 18, 2022 | Signed as free agent | Xiomer Guacache | — | Detroit Tigers | Detroit Tigers signed free agent RHP Xiomer Guacache to a minor league contract. |
| Mar 18, 2022 | Signed as free agent | Geury Rodriguez | — | Texas Rangers | Texas Rangers signed free agent LHP Geury Rodriguez to a minor league contract. |
| Mar 18, 2022 | Signed as free agent | Yoerys Hernandez | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent LHP Yoerys Hernandez to a minor league contract. |
| Mar 18, 2022 | Signed as free agent | Henson Leal | — | Kansas City Royals | Kansas City Royals signed free agent RHP Henson Leal to a minor league contract. |
| Mar 17, 2022 | Signed as free agent | Unnamed | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP Jason Adam, , , , , and. |
| Mar 17, 2022 | Signed as free agent | Travis Jankowski | — | New York Mets | New York Mets signed free agent CF Travis Jankowski to a minor league contract and invited him to spring training. |
| Mar 17, 2022 | Signed as free agent | Chasen Shreve | — | New York Mets | New York Mets signed free agent LHP Chasen Shreve to a minor league contract and invited him to spring training. |
| Mar 17, 2022 | Signed as free agent | Austin Brice | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent RHP Austin Brice to a minor league contract and invited him to spring training. |
| Mar 17, 2022 | Signed as free agent | Chase De Jong | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent RHP Chase De Jong to a minor league contract and invited him to spring training. |
| Mar 17, 2022 | Signed as free agent | Unnamed | — | New York Yankees | New York Yankees signed free agent 1B Anthony Rizzo, and. |
| Mar 17, 2022 | Signed as free agent | Kyle Kubat | — | Chicago White Sox | Chicago White Sox signed free agent LHP Kyle Kubat to a minor league contract and invited him to spring training. |
| Mar 17, 2022 | Signed as free agent | Nelson Cruz | — | Washington Nationals | Washington Nationals signed free agent DH Nelson Cruz. |
| Mar 17, 2022 | Signed as free agent | Alex Colomé | — | Colorado Rockies | Colorado Rockies signed free agent RHP Alex Colome. |
| Mar 17, 2022 | Signed as free agent | Andrew Chafin | — | Detroit Tigers | Detroit Tigers signed free agent LHP Andrew Chafin. |
| Mar 17, 2022 | Signed as free agent | Brad Miller | — | Texas Rangers | Texas Rangers signed free agent SS Brad Miller. |
| Mar 17, 2022 | Signed as free agent | Jimmy Nelson | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Jimmy Nelson. |
| Mar 17, 2022 | Signed as free agent | Joc Pederson | — | San Francisco Giants | San Francisco Giants signed free agent CF Joc Pederson. |
| Mar 17, 2022 | Signed as free agent | Jake Jewell | — | Cleveland Guardians | Cleveland Guardians signed free agent RHP Jake Jewell to a minor league contract and invited him to spring training. |
| Mar 17, 2022 | Signed as free agent | Ian Gibaut | — | Cleveland Guardians | Cleveland Guardians signed free agent RHP Ian Gibaut to a minor league contract and invited him to spring training. |
| Mar 17, 2022 | Signed as free agent | Chris Martin | — | Chicago Cubs | Chicago Cubs signed free agent RHP Chris Martin, and. |
| Mar 17, 2022 | Signed as free agent | Colin Moran | — | Cincinnati Reds | Cincinnati Reds signed free agent 3B Colin Moran. |
| Mar 17, 2022 | Signed as free agent | Dillon Maples | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RHP Dillon Maples to a minor league contract and invited him to spring training. |
| Mar 17, 2022 | Signed as free agent | Javi Rivera | — | Cincinnati Reds | Cincinnati Reds signed free agent RHP Javi Rivera to a minor league contract. |
| Mar 16, 2022 | Signed as free agent | Phillip Evans | — | New York Yankees | New York Yankees signed free agent 3B Phillip Evans and to a minor league contract and invited him to spring training. |
| Mar 16, 2022 | Signed as free agent | Ronald Guzmán | — | New York Yankees | New York Yankees signed free agent 1B Ronald Guzman and to a minor league contract and invited him to spring training. |
| Mar 16, 2022 | Signed as free agent | Unnamed | — | New York Yankees | New York Yankees signed free agent LF Ryan LaMarre and to a minor league contract and invited him to spring training. |
| Mar 16, 2022 | Signed as free agent | Andrew McCutchen | — | Milwaukee Brewers | Milwaukee Brewers signed free agent CF Andrew McCutchen. |
| Mar 16, 2022 | Trade | Kevin Smith | Toronto Blue Jays | Athletics | Oakland Athletics traded 3B Matt Chapman to Toronto Blue Jays for LHP Zach Logue, RHP Gunnar Hoglund, LHP Kirby Snead and SS Kevin Smith. |
| Mar 16, 2022 | Signed as free agent | Chris Ellis | — | Baltimore Orioles | Baltimore Orioles signed free agent RHP Chris Ellis to a minor league contract and invited him to spring training. |
| Mar 16, 2022 | Signed as free agent | Conner Greene | — | Baltimore Orioles | Baltimore Orioles signed free agent RHP Conner Greene to a minor league contract and invited him to spring training. |
| Mar 16, 2022 | Signed as free agent | Odúbel Herrera | — | Philadelphia Phillies | Philadelphia Phillies signed free agent CF Odubel Herrera. |
| Mar 16, 2022 | Signed as free agent | Unnamed | — | Atlanta Braves | Atlanta Braves signed free agent LF Eddie Rosario, and. |
| Mar 16, 2022 | Signed as free agent | Alex Dickerson | — | Atlanta Braves | Atlanta Braves signed free agent LF Alex Dickerson. |
| Mar 16, 2022 | Trade | Unnamed | Kansas City Royals | Cincinnati Reds | Kansas City Royals traded LHP Mike Minor and cash to Cincinnati Reds for LHP Amir Garrett. |
| Mar 16, 2022 | Signed as free agent | Chad Kuhl | — | Colorado Rockies | Colorado Rockies signed free agent RHP Chad Kuhl. |
| Mar 16, 2022 | Signed as free agent | Jose Iglesias | — | Colorado Rockies | Colorado Rockies signed free agent SS Jose Iglesias. |
| Mar 16, 2022 | Signed as free agent | Jake Diekman | — | Boston Red Sox | Boston Red Sox signed free agent LHP Jake Diekman. |
| Mar 16, 2022 | Signed as free agent | Ian Kennedy | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Ian Kennedy. |
| Mar 16, 2022 | Signed as free agent | Chance Sisco | — | Seattle Mariners | Seattle Mariners signed free agent C Chance Sisco to a minor league contract and invited him to spring training. |
| Mar 16, 2022 | Signed as free agent | David Robertson | — | Chicago Cubs | Chicago Cubs signed free agent RHP David Robertson. |
| Mar 16, 2022 | Signed as free agent | César Valdez | — | Los Angeles Angels | Los Angeles Angels signed free agent RHP Cesar Valdez to a minor league contract and invited him to spring training. |
| Mar 16, 2022 | Signed as free agent | Kurt Suzuki | — | Los Angeles Angels | Los Angeles Angels signed free agent C Kurt Suzuki. |
| Mar 16, 2022 | Signed as free agent | Sean Doolittle | — | Washington Nationals | Washington Nationals signed free agent LHP Sean Doolittle. |
| Mar 16, 2022 | Signed as free agent | Tyler Thornburg | — | Atlanta Braves | Atlanta Braves signed free agent RHP Tyler Thornburg. |
| Mar 16, 2022 | Signed as free agent | Zack Greinke | — | Kansas City Royals | Kansas City Royals signed free agent RHP Zack Greinke. |
| Mar 16, 2022 | Signed as free agent | Buck Farmer | — | Cincinnati Reds | Cincinnati Reds signed free agent RHP Buck Farmer to a minor league contract and invited him to spring training. |
| Mar 16, 2022 | Signed as free agent | Matt Davidson | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent DH Matt Davidson to a minor league contract and invited him to spring training. |
| Mar 16, 2022 | Signed as free agent | Matt Duffy | — | Los Angeles Angels | Los Angeles Angels signed free agent 3B Matt Duffy. |
| Mar 16, 2022 | Signed as free agent | Mike Ford | — | Seattle Mariners | Seattle Mariners signed free agent 1B Mike Ford to a minor league contract and invited him to spring training. |
| Mar 16, 2022 | Signed as free agent | Greg Holland | — | Texas Rangers | Texas Rangers signed free agent RHP Greg Holland to a minor league contract and invited him to spring training. |
| Mar 16, 2022 | Signed as free agent | Dan Winkler | — | Texas Rangers | Texas Rangers signed free agent RHP Dan Winkler to a minor league contract and invited him to spring training. |
| Mar 16, 2022 | Signed as free agent | Andrew Church | — | Atlanta Braves | Atlanta Braves signed free agent RHP Andrew Church to a minor league contract. |
| Mar 16, 2022 | Signed as free agent | Isrrael De La Cruz | — | Atlanta Braves | Atlanta Braves signed free agent RHP Isrrael De La Cruz to a minor league contract. |
| Mar 16, 2022 | Signed as free agent | Landon Leach | — | Atlanta Braves | Atlanta Braves signed free agent RHP Landon Leach to a minor league contract. |
| Mar 16, 2022 | Signed as free agent | Deivy Grullón | — | Boston Red Sox | Boston Red Sox signed free agent C Deivy Grullon to a minor league contract. |
| Mar 16, 2022 | Signed as free agent | Brandon Leibrandt | — | Chicago Cubs | Chicago Cubs signed free agent LHP Brandon Leibrandt to a minor league contract. |
| Mar 16, 2022 | Signed as free agent | Eric Stout | — | Chicago Cubs | Chicago Cubs signed free agent LHP Eric Stout to a minor league contract. |
| Mar 16, 2022 | Signed as free agent | Yency Almonte | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Yency Almonte to a minor league contract. |
| Mar 16, 2022 | Signed as free agent | Dakota Chalmers | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Dakota Chalmers to a minor league contract. |
| Mar 16, 2022 | Signed as free agent | Daniel Zamora | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent LHP Daniel Zamora to a minor league contract. |
| Mar 16, 2022 | Signed as free agent | Jonathan Aro | — | Los Angeles Angels | Los Angeles Angels signed free agent RHP Jonathan Aro to a minor league contract. |
| Mar 16, 2022 | Signed as free agent | AJ Ramos | — | Los Angeles Angels | Los Angeles Angels signed free agent RHP AJ Ramos to a minor league contract. |
| Mar 16, 2022 | Signed as free agent | Kean Wong | — | Los Angeles Angels | Los Angeles Angels signed free agent 2B Kean Wong to a minor league contract. |
| Mar 16, 2022 | Signed as free agent | Tim Adleman | — | New York Mets | New York Mets signed free agent RHP Tim Adleman to a minor league contract. |
| Mar 16, 2022 | Signed as free agent | Johneshwy Fargas | — | New York Mets | New York Mets signed free agent CF Johneshwy Fargas to a minor league contract. |
| Mar 16, 2022 | Signed as free agent | Tzu-Wei Lin | — | New York Mets | New York Mets signed free agent SS Tzu-Wei Lin to a minor league contract. |
| Mar 16, 2022 | Signed as free agent | Aaron Barrett | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RHP Aaron Barrett. |
| Mar 16, 2022 | Signed as free agent | Zach Green | — | Seattle Mariners | Seattle Mariners signed free agent 3B Zach Green to a minor league contract. |
| Mar 16, 2022 | Signed as free agent | Matt Lipka | — | Washington Nationals | Washington Nationals signed free agent CF Matt Lipka to a minor league contract. |
| Mar 16, 2022 | Signed as free agent | Michael Mariot | — | Washington Nationals | Washington Nationals signed free agent RHP Michael Mariot to a minor league contract. |
| Mar 16, 2022 | Signed as free agent | Erasmo Ramírez | — | Washington Nationals | Washington Nationals signed free agent RHP Erasmo Ramirez to a minor league contract. |
| Mar 16, 2022 | Signed as free agent | Aaron Sanchez | — | Washington Nationals | Washington Nationals signed free agent RHP Aaron Sanchez to a minor league contract. |
| Mar 16, 2022 | Signed as free agent | Mike Wright Jr. | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Mike Wright Jr. to a minor league contract. |
| Mar 16, 2022 | Signed as free agent | Nick Vincent | — | Atlanta Braves | Atlanta Braves signed free agent RHP Nick Vincent to a minor league contract and invited him to spring training. |
| Mar 16, 2022 | Signed as free agent | Wily Peralta | — | Detroit Tigers | Detroit Tigers signed free agent RHP Wily Peralta. |
| Mar 16, 2022 | Signed as free agent | Jose Medina | — | Kansas City Royals | Kansas City Royals signed free agent C Jose Medina to a minor league contract. |
| Mar 16, 2022 | Signed as free agent | Unnamed | — | Texas Rangers | Texas Rangers signed free agent LHP Juan Peralta to a minor league contract. |
| Mar 15, 2022 | Signed as free agent | Daniel Vogelbach | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent 1B Daniel Vogelbach. |
| Mar 15, 2022 | Signed as free agent | Heath Hembree | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent RHP Heath Hembree. |
| Mar 15, 2022 | Signed as free agent | Andrew Vasquez | — | Toronto Blue Jays | Toronto Blue Jays signed free agent LHP Andrew Vasquez. |
| Mar 15, 2022 | Signed as free agent | Zach McAllister | — | St. Louis Cardinals | St. Louis Cardinals signed free agent RHP Zach McAllister to a minor league contract and invited him to spring training. |
| Mar 15, 2022 | Signed as free agent | Chris Owings | — | Baltimore Orioles | Baltimore Orioles signed free agent SS Chris Owings to a minor league contract and invited him to spring training. |
| Mar 15, 2022 | Signed as free agent | Josh Harrison | — | Chicago White Sox | Chicago White Sox signed free agent 2B Josh Harrison. |
| Mar 15, 2022 | Signed as free agent | Unnamed | — | Boston Red Sox | Boston Red Sox signed free agent LHP Matt Strahm, and. |
| Mar 15, 2022 | Signed as free agent | Jeurys Familia | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RHP Jeurys Familia. |
| Mar 15, 2022 | Signed as free agent | Brad Hand | — | Philadelphia Phillies | Philadelphia Phillies signed free agent LHP Brad Hand. |
| Mar 15, 2022 | Signed as free agent | Andrelton Simmons | — | Chicago Cubs | Chicago Cubs signed free agent SS Andrelton Simmons. |
| Mar 15, 2022 | Signed as free agent | Niko Goodrum | — | Houston Astros | Houston Astros signed free agent 1B Niko Goodrum. |
| Mar 15, 2022 | Signed as free agent | Cody Reed | — | Tampa Bay Rays | Tampa Bay Rays signed free agent LHP Cody Reed, , and to a minor league contract and invited him to spring training. |
| Mar 15, 2022 | Signed as free agent | Collin McHugh | — | Atlanta Braves | Atlanta Braves signed free agent RHP Collin McHugh. |
| Mar 15, 2022 | Signed as free agent | JT Riddle | — | Cincinnati Reds | Cincinnati Reds signed free agent SS JT Riddle to a minor league contract. |
| Mar 15, 2022 | Signed as free agent | Drew Hutchison | — | Detroit Tigers | Detroit Tigers signed free agent RHP Drew Hutchison to a minor league contract. |
| Mar 15, 2022 | Signed as free agent | Brian Navarreto | — | Milwaukee Brewers | Milwaukee Brewers signed free agent C Brian Navarreto to a minor league contract. |
| Mar 15, 2022 | Signed as free agent | Juan Nunez | — | Toronto Blue Jays | Toronto Blue Jays signed free agent RHP Juan Nunez to a minor league contract. |
| Mar 15, 2022 | Signed as free agent | Willians Astudillo | — | Miami Marlins | Miami Marlins signed free agent C Willians Astudillo to a minor league contract. |
| Mar 15, 2022 | Signed as free agent | Shawn Armstrong | — | Miami Marlins | Miami Marlins signed free agent RHP Shawn Armstrong to a minor league contract. |
| Mar 15, 2022 | Signed as free agent | Aníbal Sánchez | — | Washington Nationals | Washington Nationals signed free agent RHP Anibal Sanchez to a minor league contract and invited him to spring training. |
| Mar 15, 2022 | Signed as free agent | Edwin Cervantes | — | Cincinnati Reds | Cincinnati Reds signed free agent LHP Edwin Cervantes to a minor league contract. |
| Mar 15, 2022 | Signed as free agent | Bryan Mitchell | — | Miami Marlins | Miami Marlins signed free agent RHP Bryan Mitchell to a minor league contract. |
| Mar 15, 2022 | Signed as free agent | Manuel German | — | Kansas City Royals | Kansas City Royals signed free agent 1B Manuel German to a minor league contract. |
| Mar 15, 2022 | Signed as free agent | Antonio Florido | — | Detroit Tigers | Detroit Tigers signed free agent RHP Antonio Florido to a minor league contract. |
| Mar 15, 2022 | Signed as free agent | Marcos Fortunato | — | Washington Nationals | Washington Nationals signed free agent RHP Marcos Fortunato to a minor league contract. |
| Mar 14, 2022 | Signed as free agent | Chris Herrmann | — | Washington Nationals | Washington Nationals signed free agent C Chris Herrmann to a minor league contract and invited him to spring training. |
| Mar 14, 2022 | Signed as free agent | Gerardo Parra | — | Washington Nationals | Washington Nationals signed free agent LF Gerardo Parra to a minor league contract and invited him to spring training. |
| Mar 14, 2022 | Signed as free agent | Patrick Weigel | — | Seattle Mariners | Seattle Mariners signed free agent RHP Patrick Weigel to a minor league contract and invited him to spring training. |
| Mar 14, 2022 | Signed as free agent | Jakob Junis | — | San Francisco Giants | San Francisco Giants signed free agent RHP Jakob Junis. |
| Mar 14, 2022 | Signed as free agent | Forrest Wall | — | Seattle Mariners | Seattle Mariners signed free agent 2B Forrest Wall to a minor league contract and invited him to spring training. |
| Mar 14, 2022 | Signed as free agent | Joe Kelly | — | Chicago White Sox | Chicago White Sox signed free agent RHP Joe Kelly. |
| Mar 14, 2022 | Signed as free agent | Vince Velasquez | — | Chicago White Sox | Chicago White Sox signed free agent RHP Vince Velasquez. |
| Mar 14, 2022 | Signed as free agent | Robinson Chirinos | — | Baltimore Orioles | Baltimore Orioles signed free agent C Robinson Chirinos. |
| Mar 14, 2022 | Trade | Ryan Cusick | Atlanta Braves | Athletics | Oakland Athletics traded 1B Matt Olson to Atlanta Braves for CF Cristian Pache, C Shea Langeliers, RHP Ryan Cusick and RHP Joey Estes. |
| Mar 14, 2022 | Signed as free agent | Steven Souza Jr. | — | Seattle Mariners | Seattle Mariners signed free agent RF Steven Souza Jr. to a minor league contract and invited him to spring training. |
| Mar 14, 2022 | Signed as free agent | Ryan Lavarnway | — | Detroit Tigers | Detroit Tigers signed free agent C Ryan Lavarnway to a minor league contract and invited him to spring training. |
| Mar 14, 2022 | Signed as free agent | Chase Anderson | — | Detroit Tigers | Detroit Tigers signed free agent RHP Chase Anderson to a minor league contract and invited him to spring training. |
| Mar 14, 2022 | Signed as free agent | Nick Ciuffo | — | Chicago White Sox | Chicago White Sox signed free agent C Nick Ciuffo and to a minor league contract and invited him to spring training. |
| Mar 14, 2022 | Signed as free agent | Miguel Díaz | — | Detroit Tigers | Detroit Tigers signed free agent RHP Miguel Diaz to a minor league contract and invited him to spring training. |
| Mar 14, 2022 | Signed as free agent | Ramón Rosso | — | Detroit Tigers | Detroit Tigers signed free agent RHP Ramon Rosso and to a minor league contract and invited him to spring training. |
| Mar 14, 2022 | Trade | Jake Fraley | Seattle Mariners | Cincinnati Reds | Cincinnati Reds traded LF Jesse Winker and 3B Eugenio Suarez to Seattle Mariners for RHP Justin Dunn, CF Jake Fraley, LHP Brandon Williamson and Player To Be Named Later. |
| Mar 14, 2022 | Signed as free agent | Yusei Kikuchi | — | Toronto Blue Jays | Toronto Blue Jays signed free agent LHP Yusei Kikuchi. |
| Mar 14, 2022 | Signed as free agent | Ehire Adrianza | — | Washington Nationals | Washington Nationals signed free agent SS Ehire Adrianza. |
| Mar 14, 2022 | Signed as free agent | Steve Cishek | — | Washington Nationals | Washington Nationals signed free agent RHP Steve Cishek. |
| Mar 14, 2022 | Released | Zack Burdi | — | Arizona Diamondbacks | Arizona Diamondbacks released RHP Zack Burdi. |
| Mar 14, 2022 | Signed as free agent | Luke Maile | — | Cleveland Guardians | Cleveland Guardians signed free agent C Luke Maile. |
| Mar 14, 2022 | Signed as free agent | Adam Ottavino | — | New York Mets | New York Mets signed free agent RHP Adam Ottavino. |
| Mar 14, 2022 | Signed as free agent | Martín Pérez | — | Texas Rangers | Texas Rangers signed free agent LHP Martin Perez. |
| Mar 14, 2022 | Signed as free agent | Jake Marisnick | — | Texas Rangers | Texas Rangers signed free agent CF Jake Marisnick to a minor league contract and invited him to spring training. |
| Mar 14, 2022 | Signed as free agent | Brandon Workman | — | Texas Rangers | Texas Rangers signed free agent RHP Brandon Workman to a minor league contract and invited him to spring training. |
| Mar 14, 2022 | Signed as free agent | Matt Moore | — | Texas Rangers | Texas Rangers signed free agent LHP Matt Moore to a minor league contract and invited him to spring training. |
| Mar 14, 2022 | Signed as free agent | Austin Pruitt | — | Athletics | Oakland Athletics signed free agent RHP Austin Pruitt to a minor league contract and invited him to spring training. |
| Mar 14, 2022 | Signed as free agent | Grayson Greiner | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent C Grayson Greiner to a minor league contract and invited him to spring training. |
| Mar 14, 2022 | Signed as free agent | Yorvin Pantoja | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent LHP Yorvin Pantoja to a minor league contract and invited him to spring training. |
| Mar 14, 2022 | Signed as free agent | Jesse Chavez | — | Chicago Cubs | Chicago Cubs signed free agent RHP Jesse Chavez to a minor league contract. |
| Mar 14, 2022 | Signed as free agent | Carlos Rodón | — | San Francisco Giants | San Francisco Giants signed free agent LHP Carlos Rodon. |
| Mar 14, 2022 | Signed as free agent | Ovis Portes | — | Boston Red Sox | Boston Red Sox signed free agent RHP Ovis Portes to a minor league contract. |
| Mar 14, 2022 | Signed as free agent | Frankeli Arias | — | Chicago White Sox | Chicago White Sox signed free agent LHP Frankeli Arias to a minor league contract. |
| Mar 14, 2022 | Signed as free agent | Jeremmy Santos | — | Kansas City Royals | Kansas City Royals signed free agent RHP Jeremmy Santos to a minor league contract. |
| Mar 14, 2022 | Signed as free agent | Leandro Alsinois | — | Chicago White Sox | Chicago White Sox signed free agent CF Leandro Alsinois to a minor league contract. |
| Mar 13, 2022 | Signed as free agent | Jacob Barnes | — | Detroit Tigers | Detroit Tigers signed free agent RHP Jacob Barnes to a minor league contract and invited him to spring training. |
| Mar 13, 2022 | Signed as free agent | Ricardo Pinto | — | Detroit Tigers | Detroit Tigers signed free agent RHP Ricardo Pinto to a minor league contract and invited him to spring training. |
| Mar 13, 2022 | Signed as free agent | Jimmy Cordero | — | New York Yankees | New York Yankees signed free agent RHP Jimmy Cordero to a minor league contract and invited him to spring training. |
| Mar 13, 2022 | Signed as free agent | Manny Banuelos | — | New York Yankees | New York Yankees signed free agent LHP Manny Banuelos to a minor league contract and invited him to spring training. |
| Mar 13, 2022 | Signed as free agent | Ryan Weber | — | New York Yankees | New York Yankees signed free agent RHP Ryan Weber to a minor league contract and invited him to spring training. |
| Mar 13, 2022 | Signed as free agent | Rob Brantly | — | New York Yankees | New York Yankees signed free agent C Rob Brantly to a minor league contract and invited him to spring training. |
| Mar 13, 2022 | Signed as free agent | Jasseel De La Cruz | — | Atlanta Braves | Atlanta Braves signed free agent RHP Jasseel De La Cruz to a minor league contract and invited him to spring training. |
| Mar 13, 2022 | Signed as free agent | Ryan Goins | — | Atlanta Braves | Atlanta Braves signed free agent 2B Ryan Goins to a minor league contract and invited him to spring training. |
| Mar 13, 2022 | Signed as free agent | Joe Biagini | — | Toronto Blue Jays | Toronto Blue Jays signed free agent RHP Joe Biagini to a minor league contract and invited him to spring training. |
| Mar 13, 2022 | Signed as free agent | Greg Bird | — | Toronto Blue Jays | Toronto Blue Jays signed free agent 1B Greg Bird to a minor league contract and invited him to spring training. |
| Mar 13, 2022 | Signed as free agent | Tyler Heineman | — | Toronto Blue Jays | Toronto Blue Jays signed free agent C Tyler Heineman to a minor league contract and invited him to spring training. |
| Mar 13, 2022 | Signed as free agent | Zack Erwin | — | Tampa Bay Rays | Tampa Bay Rays signed free agent LHP Zack Erwin to a minor league contract and invited him to spring training. |
| Mar 13, 2022 | Signed as free agent | David McKay | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP David McKay to a minor league contract and invited him to spring training. |
| Mar 13, 2022 | Signed as free agent | Ty Blach | — | Colorado Rockies | Colorado Rockies signed free agent LHP Ty Blach to a minor league contract and invited him to spring training. |
| Mar 13, 2022 | Signed as free agent | JD Hammer | — | Colorado Rockies | Colorado Rockies signed free agent RHP JD Hammer to a minor league contract and invited him to spring training. |
| Mar 13, 2022 | Signed as free agent | Scott Schebler | — | Colorado Rockies | Colorado Rockies signed free agent RF Scott Schebler to a minor league contract and invited him to spring training. |
| Mar 13, 2022 | Signed as free agent | Juan Minaya | — | Minnesota Twins | Minnesota Twins signed free agent RHP Juan Minaya to a minor league contract and invited him to spring training. |
| Mar 13, 2022 | Signed as free agent | Lewis Brinson | — | Houston Astros | Houston Astros signed free agent CF Lewis Brinson to a minor league contract and invited him to spring training. |
| Mar 13, 2022 | Trade | Francis Peguero | Cincinnati Reds | Minnesota Twins | Cincinnati Reds traded RHP Sonny Gray and RHP Francis Peguero to Minnesota Twins for RHP Chase Petty. |
| Mar 13, 2022 | Signed as free agent | Tim Locastro | — | New York Yankees | New York Yankees signed free agent LF Tim Locastro. |
| Mar 13, 2022 | Signed as free agent | Clayton Kershaw | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent LHP Clayton Kershaw, and. |
| Mar 13, 2022 | Signed as free agent | Nick Wittgren | — | St. Louis Cardinals | St. Louis Cardinals signed free agent RHP Nick Wittgren, and. |
| Mar 13, 2022 | Signed as free agent | Anthony Bemboom | — | Baltimore Orioles | Baltimore Orioles signed free agent C Anthony Bemboom to a minor league contract and invited him to spring training. |
| Mar 13, 2022 | Trade | David Fry | Milwaukee Brewers | Cleveland Guardians | Milwaukee Brewers traded C David Fry to Cleveland Guardians. |
| Mar 13, 2022 | Signed as free agent | José Castillo | — | San Diego Padres | San Diego Padres signed free agent LHP Jose Castillo to a minor league contract and invited him to spring training. |
| Mar 13, 2022 | Signed as free agent | C.J. Hinojosa | — | San Diego Padres | San Diego Padres signed free agent SS C.J. Hinojosa to a minor league contract and invited him to spring training. |
| Mar 13, 2022 | Signed as free agent | Luis Liberato | — | San Diego Padres | San Diego Padres signed free agent CF Luis Liberato to a minor league contract and invited him to spring training. |
| Mar 13, 2022 | Signed as free agent | Nomar Mazara | — | San Diego Padres | San Diego Padres signed free agent RF Nomar Mazara to a minor league contract and invited him to spring training. |
| Mar 13, 2022 | Signed as free agent | Thomas Milone | — | San Diego Padres | San Diego Padres signed free agent CF Thomas Milone to a minor league contract and invited him to spring training. |
| Mar 13, 2022 | Signed as free agent | Trayce Thompson | — | San Diego Padres | San Diego Padres signed free agent RF Trayce Thompson to a minor league contract and invited him to spring training. |
| Mar 13, 2022 | Trade | Gary Sánchez | New York Yankees | Minnesota Twins | New York Yankees traded C Gary Sanchez and 3B Gio Urshela to Minnesota Twins for 3B Josh Donaldson, 3B Isiah Kiner-Falefa and C Ben Rortvedt. |
| Mar 13, 2022 | Signed as free agent | Brad Boxberger | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Brad Boxberger, and. |
| Mar 13, 2022 | Signed as free agent | Austin Romine | — | Los Angeles Angels | Los Angeles Angels signed free agent C Austin Romine to a minor league contract and invited him to spring training. |
| Mar 12, 2022 | Trade | Isiah Kiner-Falefa | Texas Rangers | Minnesota Twins | Minnesota Twins traded C Mitch Garver to Texas Rangers for 3B Isiah Kiner-Falefa and RHP Ronny Henriquez. |
| Mar 12, 2022 | Signed as free agent | Justin Verlander | — | Houston Astros | Houston Astros signed free agent RHP Justin Verlander, and. |
| Mar 12, 2022 | Signed as free agent | Jordan Lyles | — | Baltimore Orioles | Baltimore Orioles signed free agent RHP Jordan Lyles. |
| Mar 12, 2022 | Trade | J.T. Ginn | New York Mets | Athletics | Oakland Athletics traded RHP Chris Bassitt to New York Mets for RHP Adam Oller and RHP J.T. Ginn. |
| Mar 12, 2022 | Signed as free agent | Eriberto Vasquez | — | Cleveland Guardians | Cleveland Guardians signed free agent RHP Eriberto Vasquez to a minor league contract. |
| Mar 11, 2022 | Signed as free agent | Drew VerHagen | — | St. Louis Cardinals | St. Louis Cardinals signed free agent RHP Drew VerHagen. |
| Mar 11, 2022 | Signed as free agent | Taylor Davis | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent 3B Taylor Davis. |
| Mar 11, 2022 | Signed as free agent | Ryan Castellani | — | Athletics | Oakland Athletics signed free agent RHP Ryan Castellani to a minor league contract and invited him to spring training. |
| Mar 11, 2022 | Signed as free agent | Justin Grimm | — | Athletics | Oakland Athletics signed free agent RHP Justin Grimm to a minor league contract and invited him to spring training. |
| Mar 11, 2022 | Signed as free agent | Dany Jiménez | — | Athletics | Oakland Athletics signed free agent RHP Dany Jimenez to a minor league contract and invited him to spring training. |
| Mar 11, 2022 | Signed as free agent | Dérmis Garcia | — | Athletics | Oakland Athletics signed free agent 3B Dermis Garcia to a minor league contract and invited him to spring training. |
| Mar 11, 2022 | Signed as free agent | Christian Lopes | — | Athletics | Oakland Athletics signed free agent 2B Christian Lopes to a minor league contract and invited him to spring training. |
| Mar 11, 2022 | Signed as free agent | Chester Pimentel | — | Athletics | Oakland Athletics signed free agent RHP Chester Pimentel to a minor league contract and invited him to spring training. |
| Mar 11, 2022 | Signed as free agent | Franklyn Moreta | — | Miami Marlins | Miami Marlins signed free agent RHP Franklyn Moreta to a minor league contract. |
| Mar 11, 2022 | Signed as free agent | Luis Ramirez | — | Miami Marlins | Miami Marlins signed free agent RHP Luis Ramirez to a minor league contract. |
| Mar 11, 2022 | Signed as free agent | Modeifi Marte | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent 3B Modeifi Marte to a minor league contract. |
| Mar 11, 2022 | Signed as free agent | Luis Valdez | — | Kansas City Royals | Kansas City Royals signed free agent RHP Luis Valdez to a minor league contract. |
| Mar 11, 2022 | Signed as free agent | Kendry Feliz | — | Miami Marlins | Miami Marlins signed free agent SS Kendry Feliz to a minor league contract. |
| Mar 11, 2022 | Signed as free agent | Fraylin Suriel | — | Miami Marlins | Miami Marlins signed free agent RHP Fraylin Suriel to a minor league contract. |
| Mar 11, 2022 | Signed as free agent | Alfonso Perez | — | San Francisco Giants | San Francisco Giants signed free agent RHP Alfonso Perez to a minor league contract. |
| Mar 10, 2022 | Signed as free agent | Brandon Brennan | — | Atlanta Braves | Atlanta Braves signed free agent RHP Brandon Brennan to a minor league contract. |
| Mar 10, 2022 | Signed as free agent | Thomas Pannone | — | Boston Red Sox | Boston Red Sox signed free agent LHP Thomas Pannone to a minor league contract. |
| Mar 10, 2022 | Signed as free agent | Daniel Mengden | — | Kansas City Royals | Kansas City Royals signed free agent RHP Daniel Mengden to a minor league contract. |
| Mar 10, 2022 | Signed as free agent | Mike Wilson | — | Los Angeles Angels | Los Angeles Angels signed free agent CF Mike Wilson to a minor league contract. |
| Mar 10, 2022 | Signed as free agent | Parker Markel | — | Athletics | Oakland Athletics signed free agent RHP Parker Markel to a minor league contract. |
| Mar 10, 2022 | Signed as free agent | Collin Wiles | — | Athletics | Oakland Athletics signed free agent RHP Collin Wiles to a minor league contract. |
| Mar 10, 2022 | Signed as free agent | John Andreoli | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RF John Andreoli to a minor league contract. |
| Mar 10, 2022 | Signed as free agent | Cash Case | — | Philadelphia Phillies | Philadelphia Phillies signed free agent SS Cash Case to a minor league contract. |
| Mar 10, 2022 | Signed as free agent | Matt Koch | — | Seattle Mariners | Seattle Mariners signed free agent RHP Matt Koch to a minor league contract. |
| Mar 10, 2022 | Signed as free agent | Braden Shipley | — | Seattle Mariners | Seattle Mariners signed free agent RHP Braden Shipley to a minor league contract. |
| Mar 10, 2022 | Signed as free agent | Eric Stamets | — | Toronto Blue Jays | Toronto Blue Jays signed free agent SS Eric Stamets to a minor league contract. |
| Mar 10, 2022 | Signed as free agent | Seth Blair | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP Seth Blair to a minor league contract. |
| Mar 10, 2022 | Signed as free agent | Joe Hudson | — | Tampa Bay Rays | Tampa Bay Rays signed free agent C Joe Hudson to a minor league contract. |
| Mar 10, 2022 | Signed as free agent | David Rodríguez | — | Tampa Bay Rays | Tampa Bay Rays signed free agent C David Rodriguez to a minor league contract. |
| Mar 10, 2022 | Signed as free agent | Rodarni Salvador | — | Cleveland Guardians | Cleveland Guardians signed free agent RHP Rodarni Salvador to a minor league contract. |
| Mar 9, 2022 | Signed as free agent | Edgar Cabral | — | Philadelphia Phillies | Philadelphia Phillies signed free agent C Edgar Cabral to a minor league contract and invited him to spring training. |
| Mar 9, 2022 | Signed as free agent | Yordis Perera | — | New York Mets | New York Mets signed free agent 3B Yordis Perera to a minor league contract. |
| Mar 9, 2022 | Signed as free agent | Wagner Castillo | — | Cleveland Guardians | Cleveland Guardians signed free agent RHP Wagner Castillo to a minor league contract. |
| Mar 9, 2022 | Signed as free agent | Elvin Valerio | — | Detroit Tigers | Detroit Tigers signed free agent RHP Elvin Valerio to a minor league contract. |
| Mar 8, 2022 | Signed as free agent | Arden Pabst | — | Atlanta Braves | Atlanta Braves signed free agent C Arden Pabst to a minor league contract. |
| Mar 8, 2022 | Signed as free agent | Nate Hadley | — | Colorado Rockies | Colorado Rockies signed free agent RHP Nate Hadley to a minor league contract. |
| Mar 8, 2022 | Signed as free agent | Félix Paulino | — | Chicago White Sox | Chicago White Sox signed free agent RHP Felix Paulino to a minor league contract. |
| Mar 8, 2022 | Signed as free agent | Vince Vannelle | — | Chicago White Sox | Chicago White Sox signed free agent RHP Vince Vannelle to a minor league contract. |
| Mar 8, 2022 | Signed as free agent | Brandon Barker | — | Kansas City Royals | Kansas City Royals signed free agent RHP Brandon Barker to a minor league contract. |
| Mar 8, 2022 | Signed as free agent | Ty Kelly | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent LF Ty Kelly to a minor league contract. |
| Mar 8, 2022 | Signed as free agent | Kodi Medeiros | — | Los Angeles Angels | Los Angeles Angels signed free agent LHP Kodi Medeiros to a minor league contract. |
| Mar 8, 2022 | Signed as free agent | Kyle Bird | — | Seattle Mariners | Seattle Mariners signed free agent LHP Kyle Bird to a minor league contract. |
| Mar 8, 2022 | Signed as free agent | Mitch Walding | — | San Diego Padres | San Diego Padres signed free agent 3B Mitch Walding to a minor league contract. |
| Mar 8, 2022 | Signed as free agent | Carl Edwards Jr. | — | Washington Nationals | Washington Nationals signed free agent RHP Carl Edwards Jr. to a minor league contract. |
| Mar 8, 2022 | Signed as free agent | Jordan Weems | — | Washington Nationals | Washington Nationals signed free agent RHP Jordan Weems to a minor league contract. |
| Mar 8, 2022 | Signed as free agent | Dondrei Hubbard | — | Washington Nationals | Washington Nationals signed free agent C Dondrei Hubbard to a minor league contract. |
| Mar 8, 2022 | Signed as free agent | Jaylen Smith | — | Washington Nationals | Washington Nationals signed free agent IF Jaylen Smith to a minor league contract. |
| Mar 8, 2022 | Signed as free agent | Sandro Fabian | — | Texas Rangers | Texas Rangers signed free agent RF Sandro Fabian to a minor league contract. |
| Mar 8, 2022 | Signed as free agent | Hayrol Done | — | Texas Rangers | Texas Rangers signed free agent RHP Hayrol Done to a minor league contract. |
| Mar 8, 2022 | Signed as free agent | Wady Mendez | — | Texas Rangers | Texas Rangers signed free agent CF Wady Mendez to a minor league contract. |
| Mar 8, 2022 | Signed as free agent | Rayner Urbaez | — | Texas Rangers | Texas Rangers signed free agent RHP Rayner Urbaez to a minor league contract. |
| Mar 8, 2022 | Signed as free agent | Chris Suero | — | New York Mets | New York Mets signed free agent C Christopher Suero to a minor league contract. |
| Mar 7, 2022 | Signed as free agent | Buddy Baumann | — | Baltimore Orioles | Baltimore Orioles signed free agent LHP Buddy Baumann to a minor league contract. |
| Mar 7, 2022 | Signed as free agent | Wes Robertson | — | Baltimore Orioles | Baltimore Orioles signed free agent RHP Wes Robertson to a minor league contract. |
| Mar 7, 2022 | Signed as free agent | Brad Peacock | — | Kansas City Royals | Kansas City Royals signed free agent RHP Brad Peacock to a minor league contract. |
| Mar 7, 2022 | Signed as free agent | Cornelius Randolph | — | Chicago White Sox | Chicago White Sox signed free agent LF Cornelius Randolph to a minor league contract. |
| Mar 7, 2022 | Signed as free agent | Jhan Mariñez | — | Chicago White Sox | Chicago White Sox signed free agent RHP Jhan Marinez to a minor league contract. |
| Mar 7, 2022 | Signed as free agent | Tyler Higgins | — | San Diego Padres | San Diego Padres signed free agent RHP Tyler Higgins to a minor league contract. |
| Mar 7, 2022 | Signed as free agent | Arnold Prado | — | Chicago White Sox | Chicago White Sox signed free agent OF Arnold Prado to a minor league contract. |
| Mar 6, 2022 | Signed as free agent | Silvino Bracho | — | Boston Red Sox | Boston Red Sox signed free agent RHP Silvino Bracho to a minor league contract and invited him to spring training. |
| Mar 6, 2022 | Signed as free agent | Darin Gillies | — | Boston Red Sox | Boston Red Sox signed free agent RHP Darin Gillies to a minor league contract and invited him to spring training. |
| Mar 5, 2022 | Signed as free agent | Alvaro Pineda | — | Kansas City Royals | Kansas City Royals signed free agent RHP Alvaro Pineda to a minor league contract. |
| Mar 4, 2022 | Signed as free agent | Drew Maggi | — | Philadelphia Phillies | Philadelphia Phillies signed free agent SS Drew Maggi to a minor league contract. |
| Mar 4, 2022 | Signed as free agent | James Marvel | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RHP James Marvel to a minor league contract. |
| Mar 3, 2022 | Signed as free agent | Justin Williams | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RF Justin Williams to a minor league contract and invited him to spring training. |
| Mar 3, 2022 | Signed as free agent | Richard Fitts | — | New York Yankees | New York Yankees signed free agent RHP Richard Fitts to a minor league contract. |
| Mar 3, 2022 | Signed as free agent | Jhaydel Flores | — | Boston Red Sox | Boston Red Sox signed free agent SS Jhaydel Flores to a minor league contract. |
| Mar 3, 2022 | Signed as free agent | Yeriel Santos | — | Houston Astros | Houston Astros signed free agent RHP Yeriel Santos to a minor league contract. |
| Mar 3, 2022 | Signed as free agent | Wander Ventura | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP Wander Ventura to a minor league contract. |
| Mar 2, 2022 | Signed as free agent | Joe Genord | — | Philadelphia Phillies | Philadelphia Phillies signed free agent 1B Joe Genord to a minor league contract. |
| Mar 2, 2022 | Signed as free agent | Jose Ojeda | — | Atlanta Braves | Atlanta Braves signed free agent RHP Jose Ojeda to a minor league contract. |
| Mar 2, 2022 | Signed as free agent | Jesus Rodriguez | — | Atlanta Braves | Atlanta Braves signed free agent RHP Jesus Rodriguez to a minor league contract. |
| Mar 2, 2022 | Signed as free agent | Juan Veloz | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Juan Veloz to a minor league contract. |
| Mar 1, 2022 | Signed as free agent | Karl Ellison | — | Philadelphia Phillies | Philadelphia Phillies signed free agent C Karl Ellison to a minor league contract. |
| Mar 1, 2022 | Signed as free agent | Jake Miller | — | Cleveland Guardians | Cleveland Guardians signed free agent RHP Jake Miller to a minor league contract. |
| Mar 1, 2022 | Signed as free agent | Miguel Ojeda Jr. | — | Texas Rangers | Texas Rangers signed free agent C Miguel Ojeda Jr. to a minor league contract. |
| Feb 28, 2022 | Signed as free agent | Luis Aguilar | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Luis Aguilar to a minor league contract. |
| Feb 28, 2022 | Signed as free agent | Jeremy Santana | — | Texas Rangers | Texas Rangers signed free agent OF Jeremy Santana to a minor league contract. |
| Feb 27, 2022 | Signed as free agent | R.J. Alvarez | — | New York Mets | New York Mets signed free agent RHP R.J. Alvarez to a minor league contract. |
| Feb 26, 2022 | Signed as free agent | Julio Valdez | — | Chicago Cubs | Chicago Cubs signed free agent OF Julio Valdez to a minor league contract. |
| Feb 25, 2022 | Signed as free agent | Kyle Hayes | — | Kansas City Royals | Kansas City Royals signed free agent C Kyle Hayes to a minor league contract. |
| Feb 25, 2022 | Signed as free agent | Jack Snyder | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP Jack Snyder to a minor league contract. |
| Feb 25, 2022 | Signed as free agent | Steven Moyers | — | Chicago White Sox | Chicago White Sox signed free agent LHP Steven Moyers to a minor league contract. |
| Feb 25, 2022 | Signed as free agent | Jordy Luciano | — | New York Yankees | New York Yankees signed free agent RHP Jordy Luciano to a minor league contract. |
| Feb 25, 2022 | Signed as free agent | Eliazar Dishmey | — | Miami Marlins | Miami Marlins signed free agent RHP Eliazar Dishmey to a minor league contract. |
| Feb 24, 2022 | Signed as free agent | Tyler Krieger | — | Chicago White Sox | Chicago White Sox signed free agent 2B Tyler Krieger to a minor league contract. |
| Feb 24, 2022 | Signed as free agent | Ryan Grotjohn | — | Kansas City Royals | Kansas City Royals signed free agent SS Ryan Grotjohn to a minor league contract. |
| Feb 24, 2022 | Signed as free agent | Morgan McCullough | — | Kansas City Royals | Kansas City Royals signed free agent SS Morgan McCullough to a minor league contract. |
| Feb 24, 2022 | Signed as free agent | Eudry Alcantara | — | Cleveland Guardians | Cleveland Guardians signed free agent RHP Eudry Alcantara to a minor league contract. |
| Feb 23, 2022 | Signed as free agent | Kevin McCarthy | — | Chicago Cubs | Chicago Cubs signed free agent RHP Kevin McCarthy to a minor league contract. |
| Feb 23, 2022 | Signed as free agent | Isaiah Rivera | — | Minnesota Twins | Minnesota Twins signed free agent RHP Isaiah Rivera to a minor league contract. |
| Feb 23, 2022 | Signed as free agent | Luis Martinez | — | Seattle Mariners | Seattle Mariners signed free agent Luis Martinez to a minor league contract. |
| Feb 23, 2022 | Signed as free agent | Ramon Ramirez | — | Los Angeles Angels | Los Angeles Angels signed free agent OF Ramon Ramirez to a minor league contract. |
| Feb 23, 2022 | Signed as free agent | Anderson Guevara | — | Seattle Mariners | Seattle Mariners signed free agent RHP Anderson Guevara to a minor league contract. |
| Feb 23, 2022 | Signed as free agent | Luis Martinez | — | Seattle Mariners | Seattle Mariners signed free agent RHP Luis Martinez to a minor league contract. |
| Feb 22, 2022 | Signed as free agent | Tyler Danish | — | Boston Red Sox | Boston Red Sox signed free agent RHP Tyler Danish to a minor league contract. |
| Feb 22, 2022 | Signed as free agent | Robbie Glendinning | — | Kansas City Royals | Kansas City Royals signed free agent SS Robbie Glendinning to a minor league contract. |
| Feb 22, 2022 | Signed as free agent | Jose Adames | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Jose Adames to a minor league contract. |
| Feb 22, 2022 | Signed as free agent | Zack Godley | — | Cincinnati Reds | Cincinnati Reds signed free agent RHP Zack Godley. |
| Feb 22, 2022 | Signed as free agent | Leam Mendez | — | New York Yankees | New York Yankees signed free agent RHP Leam Mendez to a minor league contract. |
| Feb 21, 2022 | Signed as free agent | Wes Benjamin | — | Chicago White Sox | Chicago White Sox signed free agent LHP Wes Benjamin to a minor league contract. |
| Feb 21, 2022 | Signed as free agent | Agustin Acosta | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent CF Agustin Acosta to a minor league contract. |
| Feb 21, 2022 | Signed as free agent | Juan Bello | — | Chicago Cubs | Chicago Cubs signed free agent RHP Juan Bello to a minor league contract. |
| Feb 20, 2022 | Signed as free agent | Jared Robinson | — | Atlanta Braves | Atlanta Braves signed free agent RHP Jared Robinson to a minor league contract. |
| Feb 20, 2022 | Signed as free agent | Brandyn Sittinger | — | Atlanta Braves | Atlanta Braves signed free agent RHP Brandyn Sittinger to a minor league contract. |
| Feb 20, 2022 | Signed as free agent | Andres Angulo | — | Baltimore Orioles | Baltimore Orioles signed free agent C Andres Angulo to a minor league contract. |
| Feb 20, 2022 | Signed as free agent | Patrick Kivlehan | — | Chicago White Sox | Chicago White Sox signed free agent RF Patrick Kivlehan to a minor league contract. |
| Feb 20, 2022 | Signed as free agent | Reed Garrett | — | Washington Nationals | Washington Nationals signed free agent RHP Reed Garrett to a minor league contract. |
| Feb 20, 2022 | Signed as free agent | Jose Escobar | — | Chicago Cubs | Chicago Cubs signed free agent SS Jose Escobar to a minor league contract. |
| Feb 20, 2022 | Signed as free agent | Arod McKenzie | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent LHP Arod McKenzie to a minor league contract. |
| Feb 20, 2022 | Signed as free agent | David Bracho | — | Chicago Cubs | Chicago Cubs signed free agent RHP David Bracho to a minor league contract. |
| Feb 20, 2022 | Signed as free agent | Carlos Altuve | — | Chicago Cubs | Chicago Cubs signed free agent C Carlos Altuve to a minor league contract. |
| Feb 19, 2022 | Signed as free agent | Nick Green | — | Cincinnati Reds | Cincinnati Reds signed free agent RHP Nick Green to a minor league contract. |
| Feb 19, 2022 | Signed as free agent | Zach Neal | — | Colorado Rockies | Colorado Rockies signed free agent RHP Zach Neal to a minor league contract. |
| Feb 19, 2022 | Signed as free agent | Wanmer Ramirez | — | Detroit Tigers | Detroit Tigers signed free agent RHP Wanmer Ramirez to a minor league contract. |
| Feb 18, 2022 | Signed as free agent | Shed Long Jr. | — | Baltimore Orioles | Baltimore Orioles signed free agent 2B Shed Long Jr. to a minor league contract. |
| Feb 18, 2022 | Signed as free agent | Elian Cortorreal | — | Atlanta Braves | Atlanta Braves signed free agent SS Elian Cortorreal to a minor league contract. |
| Feb 18, 2022 | Signed as free agent | Juan Sanchez | — | Atlanta Braves | Atlanta Braves signed free agent RHP Juan Sanchez to a minor league contract. |
| Feb 17, 2022 | Signed as free agent | Tayler Scott | — | San Diego Padres | San Diego Padres signed free agent RHP Tayler Scott to a minor league contract. |
| Feb 17, 2022 | Signed as free agent | Anderson Estevez | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Anderson Estevez to a minor league contract. |
| Feb 16, 2022 | Signed as free agent | Cam Booser | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent LHP Cam Booser to a minor league contract. |
| Feb 16, 2022 | Signed as free agent | Félix Peña | — | New York Mets | New York Mets signed free agent RHP Felix Pena to a minor league contract. |
| Feb 16, 2022 | Signed as free agent | Elliot Soto | — | Minnesota Twins | Minnesota Twins signed free agent SS Elliot Soto to a minor league contract. |
| Feb 16, 2022 | Signed as free agent | Palmer Wenzel | — | Houston Astros | Houston Astros signed free agent RHP Palmer Wenzel to a minor league contract. |
| Feb 16, 2022 | Signed as free agent | Eris Albino | — | New York Mets | New York Mets signed free agent RHP Eris Albino to a minor league contract. |
| Feb 16, 2022 | Signed as free agent | Rodolfo Garrido | — | New York Mets | New York Mets signed free agent RHP Rodolfo Garrido to a minor league contract. |
| Feb 14, 2022 | Signed as free agent | Josh Ockimey | — | Philadelphia Phillies | Philadelphia Phillies signed free agent 1B Josh Ockimey to a minor league contract. |
| Feb 14, 2022 | Signed as free agent | Nolan Watson | — | San Diego Padres | San Diego Padres signed free agent RHP Nolan Watson to a minor league contract. |
| Feb 14, 2022 | Signed as free agent | Robbie Erlin | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent LHP Robbie Erlin to a minor league contract and invited him to spring training. |
| Feb 14, 2022 | Signed as free agent | Juan Ruiz | — | Detroit Tigers | Detroit Tigers signed free agent RHP Juan Ruiz to a minor league contract. |
| Feb 14, 2022 | Signed as free agent | Pedro Paulino | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP Pedro Paulino to a minor league contract. |
| Feb 12, 2022 | Signed as free agent | Stefen Romero | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RF Stefen Romero to a minor league contract. |
| Feb 11, 2022 | Signed as free agent | Ryan Lillie | — | San Diego Padres | San Diego Padres signed free agent RHP Ryan Lillie to a minor league contract. |
| Feb 11, 2022 | Signed as free agent | Abel Mendez | — | Houston Astros | Houston Astros signed free agent P Abel Mendez to a minor league contract. |
| Feb 10, 2022 | Signed as free agent | Chris Betts | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent C Chris Betts to a minor league contract. |
| Feb 10, 2022 | Signed as free agent | Ian McKinney | — | Seattle Mariners | Seattle Mariners signed free agent LHP Ian McKinney to a minor league contract. |
| Feb 10, 2022 | Signed as free agent | Dillon Overton | — | Colorado Rockies | Colorado Rockies signed free agent LHP Dillon Overton to a minor league contract. |
| Feb 10, 2022 | Signed as free agent | Daniel Gossett | — | Minnesota Twins | Minnesota Twins signed free agent RHP Daniel Gossett to a minor league contract. |
| Feb 10, 2022 | Signed as free agent | Jose Betancourt | — | Minnesota Twins | Minnesota Twins signed free agent RHP Jose Betancourt to a minor league contract. |
| Feb 9, 2022 | Signed as free agent | Roberto Ramos | — | Boston Red Sox | Boston Red Sox signed free agent 1B Roberto Ramos to a minor league contract and invited him to spring training. |
| Feb 9, 2022 | Signed as free agent | Yolmer Sánchez | — | Boston Red Sox | Boston Red Sox signed free agent 2B Yolmer Sanchez to a minor league contract and invited him to spring training. |
| Feb 9, 2022 | Signed as free agent | Jason Creasy | — | Atlanta Braves | Atlanta Braves signed free agent RHP Jason Creasy to a minor league contract. |
| Feb 9, 2022 | Signed as free agent | Carlos Sanabria | — | Detroit Tigers | Detroit Tigers signed free agent RHP Carlos Sanabria to a minor league contract. |
| Feb 9, 2022 | Signed as free agent | Will Carter | — | Chicago White Sox | Chicago White Sox signed free agent RHP Will Carter to a minor league contract. |
| Feb 9, 2022 | Signed as free agent | Matthew McGarry | — | Chicago White Sox | Chicago White Sox signed free agent RHP Matthew McGarry to a minor league contract. |
| Feb 9, 2022 | Signed as free agent | Bowen Plagge | — | Chicago White Sox | Chicago White Sox signed free agent P Bowen Plagge to a minor league contract. |
| Feb 9, 2022 | Signed as free agent | Daniel Robertson | — | Minnesota Twins | Minnesota Twins signed free agent 2B Daniel Robertson to a minor league contract. |
| Feb 9, 2022 | Signed as free agent | Tim Beckham | — | Minnesota Twins | Minnesota Twins signed free agent SS Tim Beckham to a minor league contract. |
| Feb 9, 2022 | Signed as free agent | Cody Carroll | — | San Francisco Giants | San Francisco Giants signed free agent RHP Cody Carroll to a minor league contract. |
| Feb 9, 2022 | Signed as free agent | Danny Young | — | Seattle Mariners | Seattle Mariners signed free agent LHP Danny Young to a minor league contract. |
| Feb 9, 2022 | Signed as free agent | Cameron Ming | — | Seattle Mariners | Seattle Mariners signed free agent LHP Cameron Ming to a minor league contract. |
| Feb 9, 2022 | Signed as free agent | Dusten Knight | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP Dusten Knight to a minor league contract. |
| Feb 9, 2022 | Signed as free agent | Taylor Gushue | — | Washington Nationals | Washington Nationals signed free agent C Taylor Gushue to a minor league contract. |
| Feb 9, 2022 | Signed as free agent | Ronald Herrera | — | Washington Nationals | Washington Nationals signed free agent RHP Ronald Herrera to a minor league contract. |
| Feb 9, 2022 | Signed as free agent | Zach Lee | — | Colorado Rockies | Colorado Rockies signed free agent RHP Zach Lee to a minor league contract. |
| Feb 9, 2022 | Signed as free agent | Eric Thames | — | Athletics | Oakland Athletics signed free agent 1B Eric Thames to a minor league contract. |
| Feb 9, 2022 | Signed as free agent | Anthony Vizcaya | — | New York Mets | New York Mets signed free agent RHP Anthony Vizcaya to a minor league contract. |
| Feb 9, 2022 | Signed as free agent | Logan Verrett | — | Washington Nationals | Washington Nationals signed free agent RHP Logan Verrett to a minor league contract. |
| Feb 8, 2022 | Signed as free agent | Matt Dermody | — | Chicago Cubs | Chicago Cubs signed free agent LHP Matt Dermody to a minor league contract. |
| Feb 8, 2022 | Signed as free agent | Jonathan Morales | — | Colorado Rockies | Colorado Rockies signed free agent C Jonathan Morales to a minor league contract. |
| Feb 8, 2022 | Signed as free agent | Asher Wojciechowski | — | Seattle Mariners | Seattle Mariners signed free agent RHP Asher Wojciechowski to a minor league contract. |
| Feb 8, 2022 | Signed as free agent | Erick Mejia | — | Seattle Mariners | Seattle Mariners signed free agent SS Erick Mejia to a minor league contract. |
| Feb 8, 2022 | Signed as free agent | Jamil Vanheyningen | — | Chicago White Sox | Chicago White Sox signed free agent RHP Jamil Vanheyningen to a minor league contract. |
| Feb 8, 2022 | Signed as free agent | Jordy Arias | — | Texas Rangers | Texas Rangers signed free agent RHP Jordy Arias to a minor league contract. |
| Feb 8, 2022 | Signed as free agent | Victor Ortega | — | Miami Marlins | Miami Marlins signed free agent C Victor Ortega to a minor league contract. |
| Feb 8, 2022 | Signed as free agent | Geral Gil | — | Texas Rangers | Texas Rangers signed free agent RHP Geral Gil to a minor league contract. |
| Feb 7, 2022 | Signed as free agent | Joe McCarthy | — | Texas Rangers | Texas Rangers signed free agent LF Joe McCarthy to a minor league contract and invited him to spring training. |
| Feb 7, 2022 | Signed as free agent | Jack López | — | Detroit Tigers | Detroit Tigers signed free agent SS Jack Lopez to a minor league contract. |
| Feb 7, 2022 | Signed as free agent | Cole Duensing | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Cole Duensing to a minor league contract. |
| Feb 7, 2022 | Signed as free agent | A.J. Candelario | — | Miami Marlins | Miami Marlins signed free agent RHP A.J. Candelario to a minor league contract. |
| Feb 7, 2022 | Signed as free agent | Luis Torres | — | Los Angeles Angels | Los Angeles Angels signed free agent OF Luis Torres to a minor league contract. |
| Feb 7, 2022 | Signed as free agent | Richy Valdez | — | Kansas City Royals | Kansas City Royals signed free agent RHP Richy Valdez to a minor league contract. |
| Feb 5, 2022 | Signed as free agent | Ben Baggett | — | Toronto Blue Jays | Toronto Blue Jays signed free agent RHP Ben Baggett to a minor league contract. |
| Feb 5, 2022 | Signed as free agent | Mauricio Maican | — | Houston Astros | Houston Astros signed free agent RHP Mauricio Maican to a minor league contract. |
| Feb 5, 2022 | Signed as free agent | Gilberto Rojas | — | Cincinnati Reds | Cincinnati Reds signed free agent C Gilberto Rojas to a minor league contract. |
| Feb 4, 2022 | Signed as free agent | Alexander Orasma | — | Kansas City Royals | Kansas City Royals signed free agent 3B Alexander Orasma to a minor league contract. |
| Feb 3, 2022 | Signed as free agent | Juan Centeno | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent C Juan Centeno to a minor league contract. |
| Feb 3, 2022 | Signed as free agent | Ernesto Disla | — | New York Yankees | New York Yankees signed free agent RHP Ernesto Disla to a minor league contract. |
| Feb 3, 2022 | Signed as free agent | Carlos Lagrange | — | New York Yankees | New York Yankees signed free agent RHP Carlos Lagrange to a minor league contract. |
| Feb 3, 2022 | Signed as free agent | Johan Contreras | — | New York Yankees | New York Yankees signed free agent C Johan Contreras to a minor league contract. |
| Feb 2, 2022 | Signed as free agent | Dan Straily | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Dan Straily to a minor league contract. |
| Feb 2, 2022 | Signed as free agent | Tyler Hill | — | Colorado Rockies | Colorado Rockies signed free agent LF Tyler Hill to a minor league contract. |
| Feb 2, 2022 | Signed as free agent | Cole Sturgeon | — | Minnesota Twins | Minnesota Twins signed free agent CF Cole Sturgeon to a minor league contract. |
| Feb 2, 2022 | Signed as free agent | Braden Scott | — | Toronto Blue Jays | Toronto Blue Jays signed free agent LHP Braden Scott to a minor league contract. |
| Feb 1, 2022 | Signed as free agent | Roldani Baldwin | — | Boston Red Sox | Boston Red Sox signed free agent C Roldani Baldwin to a minor league contract. |
| Feb 1, 2022 | Signed as free agent | Jermaine Vanheyningen | — | Cincinnati Reds | Cincinnati Reds signed free agent RHP Jermaine Vanheyningen to a minor league contract. |
| Feb 1, 2022 | Signed as free agent | Wynton Bernard | — | Colorado Rockies | Colorado Rockies signed free agent CF Wynton Bernard to a minor league contract. |
| Feb 1, 2022 | Signed as free agent | Luis Carpio | — | Detroit Tigers | Detroit Tigers signed free agent 2B Luis Carpio to a minor league contract. |
| Feb 1, 2022 | Signed as free agent | Luis F. Castillo | — | Detroit Tigers | Detroit Tigers signed free agent RHP Luis Castillo to a minor league contract. |
| Feb 1, 2022 | Signed as free agent | Jason Lopez | — | Milwaukee Brewers | Milwaukee Brewers signed free agent C Jason Lopez to a minor league contract. |
| Feb 1, 2022 | Signed as free agent | Steven Klimek | — | Minnesota Twins | Minnesota Twins signed free agent RHP Steven Klimek to a minor league contract. |
| Feb 1, 2022 | Signed as free agent | Brandon Lawson | — | Minnesota Twins | Minnesota Twins signed free agent RHP Brandon Lawson to a minor league contract. |
| Feb 1, 2022 | Signed as free agent | Jorge Guzmán | — | San Francisco Giants | San Francisco Giants signed free agent RHP Jorge Guzman. |
| Feb 1, 2022 | Signed as free agent | Wei-Chieh Huang | — | San Francisco Giants | San Francisco Giants signed free agent RHP Wei-Chieh Huang to a minor league contract. |
| Feb 1, 2022 | Signed as free agent | Luis Ortiz | — | San Francisco Giants | San Francisco Giants signed free agent RHP Luis Ortiz to a minor league contract. |
| Feb 1, 2022 | Signed as free agent | Fernando Cruz | — | Cincinnati Reds | Cincinnati Reds signed free agent RHP Fernando Cruz to a minor league contract. |
| Feb 1, 2022 | Signed as free agent | Pedro Payano | — | Cincinnati Reds | Cincinnati Reds signed free agent RHP Pedro Payano to a minor league contract. |
| Feb 1, 2022 | Signed as free agent | Carlos Pérez | — | Colorado Rockies | Colorado Rockies signed free agent C Carlos Perez to a minor league contract. |
| Feb 1, 2022 | Signed as free agent | Raynel Espinal | — | San Francisco Giants | San Francisco Giants signed free agent RHP Raynel Espinal to a minor league contract. |
| Feb 1, 2022 | Signed as free agent | Yairo Muñoz | — | Philadelphia Phillies | Philadelphia Phillies signed free agent 3B Yairo Munoz to a minor league contract. |
| Feb 1, 2022 | Signed as free agent | Dwight Smith Jr. | — | Chicago White Sox | Chicago White Sox signed free agent LF Dwight Smith Jr. and to a minor league contract and invited him to spring training. |
| Jan 31, 2022 | Signed as free agent | John Hicks | — | Chicago Cubs | Chicago Cubs signed free agent C John Hicks to a minor league contract. |
| Jan 31, 2022 | Signed as free agent | Sam Gaviglio | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Sam Gaviglio to a minor league contract. |
| Jan 31, 2022 | Signed as free agent | Darwin Rodriguez | — | Miami Marlins | Miami Marlins signed free agent RHP Darwin Rodriguez to a minor league contract. |
| Jan 31, 2022 | Signed as free agent | Daniel Corniel | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Daniel Corniel to a minor league contract. |
| Jan 31, 2022 | Signed as free agent | Miguel Ramos | — | San Francisco Giants | San Francisco Giants signed free agent RHP Miguel Ramos to a minor league contract. |
| Jan 29, 2022 | Signed as free agent | Jackson Stephens | — | Atlanta Braves | Atlanta Braves signed free agent RHP Jackson Stephens to a minor league contract. |
| Jan 28, 2022 | Signed as free agent | Chris Rabago | — | Detroit Tigers | Detroit Tigers signed free agent C Chris Rabago to a minor league contract. |
| Jan 28, 2022 | Signed as free agent | Rudy Martin Jr. | — | Washington Nationals | Washington Nationals signed free agent CF Rudy Martin to a minor league contract. |
| Jan 28, 2022 | Signed as free agent | Mark Simon | — | Toronto Blue Jays | Toronto Blue Jays signed free agent RHP Mark Simon to a minor league contract. |
| Jan 28, 2022 | Signed as free agent | Juan Amarante | — | Philadelphia Phillies | Philadelphia Phillies signed free agent LHP Juan Amarante to a minor league contract. |
| Jan 28, 2022 | Signed as free agent | Joshua Leito | — | New York Yankees | New York Yankees signed free agent SS Joshua Leito to a minor league contract. |
| Jan 28, 2022 | Signed as free agent | Ben Serunkuma | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Ben Serunkuma to a minor league contract. |
| Jan 28, 2022 | Signed as free agent | Umar Male | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent C Umar Male to a minor league contract. |
| Jan 27, 2022 | Signed as free agent | Aaron Brooks | — | St. Louis Cardinals | St. Louis Cardinals signed free agent RHP Aaron Brooks to a minor league contract. |
| Jan 27, 2022 | Signed as free agent | Edriel Espinal | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Edriel Espinal to a minor league contract. |
| Jan 27, 2022 | Signed as free agent | Bryan Acuña | — | Minnesota Twins | Minnesota Twins signed free agent SS Bryan Acuna to a minor league contract. |
| Jan 27, 2022 | Signed as free agent | Juan Matheus | — | New York Yankees | New York Yankees signed free agent SS Juan Matheus to a minor league contract. |
| Jan 27, 2022 | Signed as free agent | Ryan Boyer | — | Toronto Blue Jays | Toronto Blue Jays signed free agent RHP Ryan Boyer to a minor league contract. |
| Jan 27, 2022 | Signed as free agent | Jerson Florentino | — | Los Angeles Angels | Los Angeles Angels signed free agent IF Jerson Florentino to a minor league contract. |
| Jan 27, 2022 | Signed as free agent | Armando Vasquez | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent LHP Armando Vasquez to a minor league contract. |
| Jan 27, 2022 | Signed as free agent | Andres Lacruz | — | New York Yankees | New York Yankees signed free agent OF Andres Lacruz to a minor league contract. |
| Jan 26, 2022 | Signed as free agent | Nick Tropeano | — | Texas Rangers | Texas Rangers signed free agent RHP Nick Tropeano to a minor league contract and invited him to spring training. |
| Jan 26, 2022 | Signed as free agent | Jordan Procyshen | — | Texas Rangers | Texas Rangers signed free agent C Jordan Procyshen to a minor league contract. |
| Jan 26, 2022 | Signed as free agent | Sal Mendez | — | Texas Rangers | Texas Rangers signed free agent LHP Sal Mendez to a minor league contract. |
| Jan 26, 2022 | Signed as free agent | Josh Sale | — | Texas Rangers | Texas Rangers signed free agent LF Josh Sale to a minor league contract. |
| Jan 26, 2022 | Signed as free agent | Federik Jimenez | — | Seattle Mariners | Seattle Mariners signed free agent RHP Federik Jimenez to a minor league contract. |
| Jan 26, 2022 | Signed as free agent | Carlos Gonzalez | — | Seattle Mariners | Seattle Mariners signed free agent C Carlos Gonzalez to a minor league contract. |
| Jan 26, 2022 | Signed as free agent | Charles Nova | — | Kansas City Royals | Kansas City Royals signed free agent IF Charles Nova to a minor league contract. |
| Jan 26, 2022 | Signed as free agent | William Calderon | — | Seattle Mariners | Seattle Mariners signed free agent RHP William Calderon to a minor league contract. |
| Jan 26, 2022 | Signed as free agent | Joaan De Jesus | — | Seattle Mariners | Seattle Mariners signed free agent RHP Joaan De Jesus to a minor league contract. |
| Jan 26, 2022 | Signed as free agent | Edinzo Marquez | — | New York Yankees | New York Yankees signed free agent RHP Edinzo Marquez to a minor league contract. |
| Jan 26, 2022 | Signed as free agent | Wuilliams Rodriguez | — | Seattle Mariners | Seattle Mariners signed free agent RHP Wuilliams Rodriguez to a minor league contract. |
| Jan 25, 2022 | Signed as free agent | Erick Hernandez | — | Chicago White Sox | Chicago White Sox signed free agent OF Erick Hernandez to a minor league contract. |
| Jan 25, 2022 | Signed as free agent | Oscar Colás | — | Chicago White Sox | Chicago White Sox signed free agent TWP Oscar Colas to a minor league contract. |
| Jan 25, 2022 | Signed as free agent | Victor Moreno | — | San Francisco Giants | San Francisco Giants signed free agent LHP Victor Moreno to a minor league contract. |
| Jan 25, 2022 | Signed as free agent | Juan De La Cruz | — | Miami Marlins | Miami Marlins signed free agent RHP Juan De La Cruz to a minor league contract. |
| Jan 25, 2022 | Signed as free agent | Sebastian Barrios | — | Seattle Mariners | Seattle Mariners signed free agent RHP Sebastian Barrios to a minor league contract. |
| Jan 24, 2022 | Signed as free agent | Eric Yardley | — | Chicago Cubs | Chicago Cubs signed free agent RHP Eric Yardley to a minor league contract. |
| Jan 24, 2022 | Signed as free agent | Michael De León | — | Cincinnati Reds | Cincinnati Reds signed free agent SS Michael De Leon to a minor league contract. |
| Jan 24, 2022 | Signed as free agent | Luis Amaya | — | Chicago White Sox | Chicago White Sox signed free agent LHP Luis Amaya to a minor league contract. |
| Jan 24, 2022 | Signed as free agent | Felipe Tejada | — | Chicago White Sox | Chicago White Sox signed free agent RHP Felipe Tejada to a minor league contract. |
| Jan 24, 2022 | Signed as free agent | Gerson Moreno | — | Detroit Tigers | Detroit Tigers signed free agent RHP Gerson Moreno to a minor league contract. |
| Jan 24, 2022 | Signed as free agent | Hamlet Marte | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent C Hamlet Marte to a minor league contract. |
| Jan 24, 2022 | Signed as free agent | Daniel Ponce de Leon | — | Los Angeles Angels | Los Angeles Angels signed free agent RHP Daniel Ponce de Leon to a minor league contract. |
| Jan 24, 2022 | Signed as free agent | Elijah Greene | — | Minnesota Twins | Minnesota Twins signed free agent OF Elijah Greene to a minor league contract. |
| Jan 24, 2022 | Signed as free agent | Nolan Long | — | Athletics | Oakland Athletics signed free agent RHP Nolan Long to a minor league contract. |
| Jan 24, 2022 | Signed as free agent | Wali Pierre | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent RHP Wali Pierre to a minor league contract. |
| Jan 24, 2022 | Signed as free agent | Daniel Camarena | — | San Diego Padres | San Diego Padres signed free agent LHP Daniel Camarena to a minor league contract. |
| Jan 24, 2022 | Signed as free agent | Nick Wells | — | Washington Nationals | Washington Nationals signed free agent LHP Nick Wells to a minor league contract. |
| Jan 23, 2022 | Signed as free agent | Colten Brewer | — | Kansas City Royals | Kansas City Royals signed free agent RHP Colten Brewer to a minor league contract. |
| Jan 22, 2022 | Signed as free agent | Matt Carasiti | — | San Francisco Giants | San Francisco Giants signed free agent RHP Matt Carasiti to a minor league contract. |
| Jan 22, 2022 | Signed as free agent | Oswald Mori | — | Houston Astros | Houston Astros signed free agent RHP Oswald Mori to a minor league contract. |
| Jan 22, 2022 | Signed as free agent | Dewis De Jesus | — | Los Angeles Angels | Los Angeles Angels signed free agent SS Dewis De Jesus to a minor league contract. |
| Jan 22, 2022 | Signed as free agent | Junior Chirinos | — | St. Louis Cardinals | St. Louis Cardinals signed free agent RHP Junior Chirinos to a minor league contract. |
| Jan 21, 2022 | Signed as free agent | Santiago Quintero | — | Los Angeles Angels | Los Angeles Angels signed free agent LHP Santiago Quintero to a minor league contract. |
| Jan 21, 2022 | Signed as free agent | Zachary Hammer | — | Chicago White Sox | Chicago White Sox signed free agent RHP Zachary Hammer to a minor league contract. |
| Jan 21, 2022 | Signed as free agent | Luis Moncada | — | Chicago White Sox | Chicago White Sox signed free agent LHP Luis Moncada to a minor league contract. |
| Jan 21, 2022 | Signed as free agent | Leonardo Lugo | — | Minnesota Twins | Minnesota Twins signed free agent RHP Leonardo Lugo to a minor league contract. |
| Jan 21, 2022 | Signed as free agent | Luis Tejeda | — | Colorado Rockies | Colorado Rockies signed free agent RHP Luis Tejeda to a minor league contract. |
| Jan 20, 2022 | Signed as free agent | Julio Pinto | — | Cincinnati Reds | Cincinnati Reds signed free agent RHP Julio Pinto to a minor league contract. |
| Jan 20, 2022 | Signed as free agent | Alberto Barriga | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent C Alberto Barriga to a minor league contract. |
| Jan 20, 2022 | Signed as free agent | Miguel Tamares | — | Tampa Bay Rays | Tampa Bay Rays signed free agent SS Miguel Tamares to a minor league contract. |
| Jan 19, 2022 | Signed as free agent | Taylor Cole | — | Boston Red Sox | Boston Red Sox signed free agent RHP Taylor Cole to a minor league contract and invited him to spring training. |
| Jan 19, 2022 | Signed as free agent | Santiago Gomez | — | New York Yankees | New York Yankees signed free agent SS Santiago Gomez to a minor league contract. |
| Jan 19, 2022 | Signed as free agent | Edinson Salgado | — | Kansas City Royals | Kansas City Royals signed free agent LHP Edinson Salgado to a minor league contract. |
| Jan 18, 2022 | Signed as free agent | Wilson Garcia | — | Washington Nationals | Washington Nationals signed free agent 1B Wilson Garcia to a minor league contract. |
| Jan 18, 2022 | Signed as free agent | Christian Crespo | — | San Diego Padres | San Diego Padres signed free agent RHP Christian Crespo to a minor league contract. |
| Jan 18, 2022 | Signed as free agent | Alen Pineda | — | Atlanta Braves | Atlanta Braves signed free agent C Alen Pineda to a minor league contract. |
| Jan 18, 2022 | Signed as free agent | Abel De Leon | — | Chicago Cubs | Chicago Cubs signed free agent C Abel De Leon to a minor league contract. |
| Jan 17, 2022 | Signed as free agent | Luis Sanchez | — | Atlanta Braves | Atlanta Braves signed free agent SS Luis Sanchez to a minor league contract. |
| Jan 17, 2022 | Signed as free agent | Yanki Jean-Baptiste | — | Cleveland Guardians | Cleveland Guardians signed free agent SS Yanki Jean-Baptiste to a minor league contract. |
| Jan 17, 2022 | Signed as free agent | Ben Walmsley | — | Cincinnati Reds | Cincinnati Reds signed free agent LHP Ben Walmsley to a minor league contract. |
| Jan 17, 2022 | Signed as free agent | Franyerber Montilla | — | Detroit Tigers | Detroit Tigers signed free agent SS Franyerber Montilla to a minor league contract. |
| Jan 17, 2022 | Signed as free agent | Gabriel Torres | — | Detroit Tigers | Detroit Tigers signed free agent RHP Gabriel Torres to a minor league contract. |
| Jan 17, 2022 | Signed as free agent | Samuel Gil | — | Detroit Tigers | Detroit Tigers signed free agent SS Samuel Gil to a minor league contract. |
| Jan 17, 2022 | Signed as free agent | Angel Garza | — | San Diego Padres | San Diego Padres signed free agent RHP Angel Garza to a minor league contract. |
| Jan 17, 2022 | Signed as free agent | Aldo Leija | — | San Diego Padres | San Diego Padres signed free agent RHP Aldo Leija to a minor league contract. |
| Jan 17, 2022 | Signed as free agent | Adan Sanchez | — | Chicago Cubs | Chicago Cubs signed free agent C Adan Sanchez to a minor league contract. |
| Jan 17, 2022 | Signed as free agent | Daniel Benschop | — | Chicago Cubs | Chicago Cubs signed free agent OF Daniel Benschop to a minor league contract. |
| Jan 17, 2022 | Signed as free agent | Josue Briceño | — | Detroit Tigers | Detroit Tigers signed free agent C Josue Briceno to a minor league contract. |
| Jan 17, 2022 | Signed as free agent | Christian Zazueta | — | New York Yankees | New York Yankees signed free agent RHP Christian Zazueta to a minor league contract. |
| Jan 17, 2022 | Signed as free agent | Nikau Pouaka-Grego | — | Philadelphia Phillies | Philadelphia Phillies signed free agent SS Nikau Pouaka-Grego to a minor league contract. |
| Jan 16, 2022 | Signed as free agent | Anderson Nova | — | Minnesota Twins | Minnesota Twins signed free agent OF Anderson Nova to a minor league contract. |
| Jan 16, 2022 | Signed as free agent | Kevin Merrell | — | Minnesota Twins | Minnesota Twins signed free agent SS Kevin Merrell to a minor league contract. |
| Jan 16, 2022 | Signed as free agent | Roque Salinas | — | Toronto Blue Jays | Toronto Blue Jays signed free agent OF Roque Salinas to a minor league contract. |
| Jan 16, 2022 | Signed as free agent | Jose Alpuria | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent CF Jose Alpuria to a minor league contract. |
| Jan 16, 2022 | Signed as free agent | Cesar Bonalde | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent OF Cesar Bonalde to a minor league contract. |
| Jan 16, 2022 | Signed as free agent | Adonis Villavicencio | — | Texas Rangers | Texas Rangers signed free agent RHP Adonis Villavicencio to a minor league contract. |
| Jan 16, 2022 | Signed as free agent | Gerson Balbino | — | Colorado Rockies | Colorado Rockies signed free agent RHP Gerson Balbino to a minor league contract. |
| Jan 16, 2022 | Signed as free agent | Jesus De La Rosa | — | Colorado Rockies | Colorado Rockies signed free agent LHP Jesus De La Rosa to a minor league contract. |
| Jan 16, 2022 | Signed as free agent | Edwin Moreno | — | Detroit Tigers | Detroit Tigers signed free agent RHP Edwin Moreno to a minor league contract. |
| Jan 16, 2022 | Signed as free agent | Hector Osorio | — | Texas Rangers | Texas Rangers signed free agent CF Hector Osorio to a minor league contract. |
| Jan 16, 2022 | Signed as free agent | Jose Florian | — | Detroit Tigers | Detroit Tigers signed free agent RHP Jose Florian to a minor league contract. |
| Jan 16, 2022 | Signed as free agent | Lou Helmig | — | Philadelphia Phillies | Philadelphia Phillies signed free agent OF Lou Helmig to a minor league contract. |
| Jan 16, 2022 | Signed as free agent | Rafael Nava | — | San Diego Padres | San Diego Padres signed free agent RHP Rafael Nava to a minor league contract. |
| Jan 16, 2022 | Signed as free agent | Yoan Valdez | — | Colorado Rockies | Colorado Rockies signed free agent RHP Yoan Valdez to a minor league contract. |
| Jan 16, 2022 | Signed as free agent | Jesus Lopez | — | Texas Rangers | Texas Rangers signed free agent C Jesus Lopez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Cristhian Vaquero | — | Washington Nationals | Washington Nationals signed free agent OF Cristhian Vaquero to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Ramon Cuevas | — | Washington Nationals | Washington Nationals signed free agent RHP Ramon Cuevas to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Jarlin Susana | — | San Diego Padres | San Diego Padres signed free agent RHP Jarlin Susana to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Albert Casado | — | Washington Nationals | Washington Nationals signed free agent 2B Albert Casado to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Misael Mojica | — | Washington Nationals | Washington Nationals signed free agent 3B Misael Mojica to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Rosman Verdugo | — | San Diego Padres | San Diego Padres signed free agent SS Rosman Verdugo to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Jorgelys Mota | — | Washington Nationals | Washington Nationals signed free agent SS Jorgelys Mota to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Yendry Rojas | — | San Diego Padres | San Diego Padres signed free agent SS Yendry Rojas to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Willy Fanas | — | New York Mets | New York Mets signed free agent OF Willy Fanas to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Marlon Perez | — | Washington Nationals | Washington Nationals signed free agent LHP Marlon Perez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Henry Bibieca | — | Houston Astros | Houston Astros signed free agent RHP Henry Bibieca to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Camilo Sanchez | — | Washington Nationals | Washington Nationals signed free agent RHP Camilo Sanchez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Won-Bin Cho | — | St. Louis Cardinals | St. Louis Cardinals signed free agent OF Won-Bin Cho to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Luis Baez | — | Houston Astros | Houston Astros signed free agent OF Luis Baez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Ernesto Mercedes | — | New York Mets | New York Mets signed free agent RHP Ernesto Mercedes to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Miguel Moreno | — | Washington Nationals | Washington Nationals signed free agent RHP Miguel Moreno to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Sandy Mejia | — | Houston Astros | Houston Astros signed free agent RHP Sandy Mejia to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Michael Perez | — | Houston Astros | Houston Astros signed free agent RHP Michael Perez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Jovi Gálvez | — | St. Louis Cardinals | St. Louis Cardinals signed free agent RHP Jovi Galvez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Edwin Gonzalez | — | Houston Astros | Houston Astros signed free agent RHP Edwin Gonzalez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Arfeni Batista | — | St. Louis Cardinals | St. Louis Cardinals signed free agent SS Arfeni Batista to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Jeffrey Mercedes | — | Cleveland Guardians | Cleveland Guardians signed free agent SS Jeffrey Mercedes to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Jose Suriel | — | St. Louis Cardinals | St. Louis Cardinals signed free agent RHP Jose Suriel to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Yonatan Henriquez | — | New York Mets | New York Mets signed free agent SS Yonatan Henriquez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Pedro Hernandez | — | Cleveland Guardians | Cleveland Guardians signed free agent SS Pedro Hernandez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Axell De Paula | — | Houston Astros | Houston Astros signed free agent OF Axell De Paula to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Jeremy Bautista | — | Washington Nationals | Washington Nationals signed free agent C Jeremy Bautista to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Marco Marcelino | — | Houston Astros | Houston Astros signed free agent OF Marco Marcelino to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Yordalin Peña | — | St. Louis Cardinals | St. Louis Cardinals signed free agent OF Yordalin Pena to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Jose Arias | — | Houston Astros | Houston Astros signed free agent OF Jose Arias to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Rafael Ramirez | — | Houston Astros | Houston Astros signed free agent SS Rafael Ramirez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Jose Sequera | — | New York Mets | New York Mets signed free agent RHP Jose Sequera to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Alberto Mendez | — | Cleveland Guardians | Cleveland Guardians signed free agent SS Alberto Mendez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Yordy Herrera | — | St. Louis Cardinals | St. Louis Cardinals signed free agent LHP Yordy Herrera to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Abrahan Tejada | — | Cleveland Guardians | Cleveland Guardians signed free agent RHP Abrahan Tejada to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Jeisel Vargas | — | New York Mets | New York Mets signed free agent SS Jeisel Vargas to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Brayan Guedez | — | Cleveland Guardians | Cleveland Guardians signed free agent SS Brayan Guedez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Gueile Borrome | — | Cleveland Guardians | Cleveland Guardians signed free agent SS Gueile Borrome to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Enrike Sevilya | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Enrike Sevilya to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Dangelo Sarmiento | — | New York Mets | New York Mets signed free agent SS Dangelo Sarmiento to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Samuel Capellan | — | Houston Astros | Houston Astros signed free agent SS Samuel Capellan to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Daniel Silva | — | New York Mets | New York Mets signed free agent C Daniel Silva to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Melkis Hernández | — | Cleveland Guardians | Cleveland Guardians signed free agent LHP Melkis Hernandez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Helder Rosario | — | Washington Nationals | Washington Nationals signed free agent C Helder Rosario to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Waner Luciano | — | Houston Astros | Houston Astros signed free agent SS Waner Luciano to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Nelfy Ynfante | — | St. Louis Cardinals | St. Louis Cardinals signed free agent RHP Nelfy Ynfante to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Jose Gomez | — | Cleveland Guardians | Cleveland Guardians signed free agent CF Jose Gomez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Frelianderson Seijas | — | New York Mets | New York Mets signed free agent RHP Frelianderson Seijas to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Moises Molero | — | Cleveland Guardians | Cleveland Guardians signed free agent CF Moises Molero to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Mairo Martinus | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent SS Mairoshendrick Martinus to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Jesús Báez | — | New York Mets | New York Mets signed free agent SS Jesus Baez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Jose Cedeno | — | Cleveland Guardians | Cleveland Guardians signed free agent C Jose Cedeno to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Johan Villegas | — | New York Mets | New York Mets signed free agent LHP Johan Villegas to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Didier Fuentes | — | Atlanta Braves | Atlanta Braves signed free agent RHP Didier Fuentes to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Orangel Rodriguez | — | New York Mets | New York Mets signed free agent C Orangel Rodriguez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Jonathan Mejía | — | St. Louis Cardinals | St. Louis Cardinals signed free agent SS Jonathan Mejia to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Moises De La Rosa | — | San Francisco Giants | San Francisco Giants signed free agent OF Moises De La Rosa to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Luis Rodriguez | — | St. Louis Cardinals | St. Louis Cardinals signed free agent C Luis Rodriguez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Leonel Sequera | — | St. Louis Cardinals | St. Louis Cardinals signed free agent RHP Leonel Sequera to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Jeffry Rosa | — | New York Mets | New York Mets signed free agent OF Jeffry Rosa to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Nelson Rada | — | Los Angeles Angels | Los Angeles Angels signed free agent OF Nelson Rada to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Randy De Jesus | — | Los Angeles Angels | Los Angeles Angels signed free agent OF Randy De Jesus to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Nixon Encarnacion | — | Los Angeles Angels | Los Angeles Angels signed free agent RHP Nixon Encarnacion to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Luis Rodriguez | — | Los Angeles Angels | Los Angeles Angels signed free agent SS Luis Rodriguez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Dario Laverde | — | Los Angeles Angels | Los Angeles Angels signed free agent C Dario Laverde to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Manuel Cazorla | — | Los Angeles Angels | Los Angeles Angels signed free agent LHP Manuel Cazorla to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Capri Ortiz | — | Los Angeles Angels | Los Angeles Angels signed free agent 3B Capri Ortiz to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Sadiel Baro | — | Los Angeles Angels | Los Angeles Angels signed free agent LHP Sadiel Baro to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Jonathan Linares | — | Los Angeles Angels | Los Angeles Angels signed free agent C Jonathan Linares to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Marco Vega | — | Los Angeles Angels | Los Angeles Angels signed free agent RHP Marco Vega to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Miguel Gomez | — | Los Angeles Angels | Los Angeles Angels signed free agent RHP Miguel Gomez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Eliezer Rivero | — | Los Angeles Angels | Los Angeles Angels signed free agent C Eliezer Rivero to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Wilifer Estrella | — | Los Angeles Angels | Los Angeles Angels signed free agent OF Wilifer Estrella to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | David Lopez | — | Los Angeles Angels | Los Angeles Angels signed free agent LHP David Lopez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Kevyn Castillo | — | Los Angeles Angels | Los Angeles Angels signed free agent CF Kevyn Castillo to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Alejandro Rodriguez | — | Los Angeles Angels | Los Angeles Angels signed free agent LHP Alejandro Rodriguez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Diego Benitez | — | Atlanta Braves | Atlanta Braves signed free agent SS Diego Benitez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Douglas Glod | — | Atlanta Braves | Atlanta Braves signed free agent CF Douglas Glod to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Jaison Chourio | — | Cleveland Guardians | Cleveland Guardians signed free agent OF Jaison Chourio to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Victor Izturis | — | Cleveland Guardians | Cleveland Guardians signed free agent C Victor Izturis to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Rafael Ramirez Jr. | — | Cleveland Guardians | Cleveland Guardians signed free agent SS Rafael Ramirez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Yorfran John | — | Cleveland Guardians | Cleveland Guardians signed free agent SS Yorfran John to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Nomar Velasquez | — | Cleveland Guardians | Cleveland Guardians signed free agent SS Nomar Velasquez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Kenni Gomez | — | Houston Astros | Houston Astros signed free agent OF Kenni Gomez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Raimy Rodriguez | — | Houston Astros | Houston Astros signed free agent RHP Raimy Rodriguez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Elian Garcia | — | Atlanta Braves | Atlanta Braves signed free agent OF Elian Garcia to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Juan Perez | — | San Francisco Giants | San Francisco Giants signed free agent C Juan Perez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Daniel Arrias | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent CF Daniel Arrias to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Victor Rodrigues | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent C Victor Rodrigues to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Alessandro Duran | — | San Francisco Giants | San Francisco Giants signed free agent C Alessandro Duran to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Adriam Santos | — | Baltimore Orioles | Baltimore Orioles signed free agent SS Adriam Santos to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Yorfran Medina | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent OF Yorfran Medina to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Franklin Gómez | — | New York Mets | New York Mets signed free agent LHP Franklin Gomez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Jhonny Martinez | — | Atlanta Braves | Atlanta Braves signed free agent RHP Jhonny Martinez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Yirber Ruiz | — | Baltimore Orioles | Baltimore Orioles signed free agent OF Yirber Ruiz to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Sean Paul Liñan | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Sean Linan to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Edwin Amparo | — | Baltimore Orioles | Baltimore Orioles signed free agent SS Edwin Amparo to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Javier Pena | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent C Javier Pena to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Jhonly Taveras | — | Atlanta Braves | Atlanta Braves signed free agent RHP Jhonly Taveras to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Samuel Munoz | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent 1B Samuel Munoz to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Luciano Romero | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Luciano Romero to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Peter Bonilla | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent LHP Peter Bonilla to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Andrés Parra | — | Baltimore Orioles | Baltimore Orioles signed free agent LHP Andres Parra to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Yoryi Simarra | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Yoryi Simarra to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Simon Juan | — | New York Mets | New York Mets signed free agent OF Simon Juan to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Accimias Morales | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Accimias Morales to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Ryan Reckley | — | San Francisco Giants | San Francisco Giants signed free agent SS Ryan Reckley to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Cristian Benavides | — | Baltimore Orioles | Baltimore Orioles signed free agent SS Cristian Benavides to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Eduardo Guerrero | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent SS Eduardo Guerrero to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Leandro Arias | — | Baltimore Orioles | Baltimore Orioles signed free agent SS Leandro Arias to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | José Noguera | — | Baltimore Orioles | Baltimore Orioles signed free agent C Jose Noguera to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Erick Arosemena | — | San Francisco Giants | San Francisco Giants signed free agent CF Erick Arosemena to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Dennys Riera | — | San Francisco Giants | San Francisco Giants signed free agent SS Dennys Riera to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Raynerd Ortega | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent SS Raynerd Ortega to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Carlos Gomez | — | San Francisco Giants | San Francisco Giants signed free agent RHP Carlos Gomez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Domingo Geronimo | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Domingo Geronimo to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Robert Gonzalez | — | Atlanta Braves | Atlanta Braves signed free agent OF Robert Gonzalez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Fernando Peguero | — | Baltimore Orioles | Baltimore Orioles signed free agent SS Fernando Peguero to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Natanael Castillo | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent SS Natanael Castillo to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Adrián Delgado | — | Baltimore Orioles | Baltimore Orioles signed free agent RHP Adrian Delgado to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Nicolas Cruz | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Nicolas Cruz to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Miguel Dominguez | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent C Miguel Dominguez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | César Prieto | — | Baltimore Orioles | Baltimore Orioles signed free agent 2B Cesar Prieto to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Edrei Campos | — | Baltimore Orioles | Baltimore Orioles signed free agent SS Edrei Campos to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Aron Estrada | — | Baltimore Orioles | Baltimore Orioles signed free agent 2B Aron Estrada to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Jholbran Herder | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Jholbran Herder to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Braylin Tavera | — | Baltimore Orioles | Baltimore Orioles signed free agent OF Braylin Tavera to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Jean Mata | — | Baltimore Orioles | Baltimore Orioles signed free agent OF Jean Mata to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Juan Oramas | — | New York Mets | New York Mets signed free agent RHP Juan Oramas to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Alfredo Velásquez | — | Baltimore Orioles | Baltimore Orioles signed free agent 3B Alfredo Velasquez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Wilson Esterlin | — | New York Mets | New York Mets signed free agent RHP Wilson Esterlin to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Juan Martínez | — | Baltimore Orioles | Baltimore Orioles signed free agent OF Juan Martinez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Jeral Perez | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent SS Jeral Perez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Christian Suarez | — | Atlanta Braves | Atlanta Braves signed free agent 3B Cristian Suarez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Oswaldo Osorio | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent SS Oswaldo Osorio to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Raylin Ramos | — | Baltimore Orioles | Baltimore Orioles signed free agent OF Raylin Ramos to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Josnaider Orellana | — | Atlanta Braves | Atlanta Braves signed free agent C Josnaider Orellana to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Cesar Rivera | — | New York Mets | New York Mets signed free agent LHP Cesar Rivera to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Elis Cuevas | — | Baltimore Orioles | Baltimore Orioles signed free agent SS Elis Cuevas to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Diego Dominguez | — | St. Louis Cardinals | St. Louis Cardinals signed free agent RHP Diego Dominguez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Andrés Nolaya | — | Baltimore Orioles | Baltimore Orioles signed free agent C Andres Nolaya to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Mauricio Estrella | — | San Francisco Giants | San Francisco Giants signed free agent RHP Mauricio Estrella to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Yuliangel De La Cruz | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Yuliangel De La Cruz to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Thomas Sosa | — | Baltimore Orioles | Baltimore Orioles signed free agent OF Thomas Sosa to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Jose Chirinos | — | New York Mets | New York Mets signed free agent RHP Jose Chirinos to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Edgar Leon | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Edgar Leon to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Ezequiel Bonilla | — | Baltimore Orioles | Baltimore Orioles signed free agent RHP Ezequiel Bonilla to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Yorvi Pirela | — | Atlanta Braves | Atlanta Braves signed free agent RHP Yorvi Pirela to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Deifran Yriarte | — | San Francisco Giants | San Francisco Giants signed free agent RHP Deifran Yriarte to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Jesús Palacios | — | Baltimore Orioles | Baltimore Orioles signed free agent RHP Jesus Palacios to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Jean Joseph | — | Toronto Blue Jays | Toronto Blue Jays signed free agent CF Jean Joseph to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Genderson Almonte | — | Atlanta Braves | Atlanta Braves signed free agent RHP Genderson Almonte to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Omar Victorino | — | New York Mets | New York Mets signed free agent RHP Omar Victorino to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Raudy Gomez | — | Toronto Blue Jays | Toronto Blue Jays signed free agent RHP Raudy Gomez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Maximo Maria | — | Atlanta Braves | Atlanta Braves signed free agent OF Maximo Maria to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Miguel Mesa | — | Baltimore Orioles | Baltimore Orioles signed free agent RHP Miguel Mesa to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Steven Castillo | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Steven Castillo to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Eminen Flores | — | Toronto Blue Jays | Toronto Blue Jays signed free agent RHP Eminen Flores to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Roiger Mujica | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Roiger Mujica to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Harold Grant | — | Minnesota Twins | Minnesota Twins signed free agent 2B Harold Grant to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Henry Tejada | — | Baltimore Orioles | Baltimore Orioles signed free agent RHP Henry Tejada to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Kosuke Matsuda | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Kosuke Matsuda to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Audie Jimenez | — | San Francisco Giants | San Francisco Giants signed free agent SS Audie Jimenez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Oscar Moreta | — | Baltimore Orioles | Baltimore Orioles signed free agent RHP Oscar Moreta to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Rodolfo Toledano | — | Toronto Blue Jays | Toronto Blue Jays signed free agent RHP Rodolfo Toledano to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Omar Munoz | — | Toronto Blue Jays | Toronto Blue Jays signed free agent RHP Omar Munoz to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Kendry Chirinos | — | Toronto Blue Jays | Toronto Blue Jays signed free agent 3B Kendry Chirinos to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Carlos Espinosa | — | Houston Astros | Houston Astros signed free agent RHP Carlos Espinosa to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Jonathan Bautista | — | Toronto Blue Jays | Toronto Blue Jays signed free agent OF Jonathan Bautista to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Alberto Hernandez | — | Houston Astros | Houston Astros signed free agent SS Alberto Hernandez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Yilber Herrera | — | Minnesota Twins | Minnesota Twins signed free agent SS Yilber Herrera to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Yasser Mercedes | — | Minnesota Twins | Minnesota Twins signed free agent OF Yasser Mercedes to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Jose Rodriguez | — | Minnesota Twins | Minnesota Twins signed free agent OF Jose Rodriguez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Ledwin Taveras | — | Minnesota Twins | Minnesota Twins signed free agent RHP Ledwin Taveras to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Juan Zapata | — | Minnesota Twins | Minnesota Twins signed free agent 2B Juan Zapata to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Faruk De La Cruz | — | Toronto Blue Jays | Toronto Blue Jays signed free agent C Faruk De La Cruz to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Aneudi Escanio | — | Toronto Blue Jays | Toronto Blue Jays signed free agent SS Aneudi Escanio to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Ali Lucena | — | Toronto Blue Jays | Toronto Blue Jays signed free agent OF Ali Lucena to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Luis Meza | — | Toronto Blue Jays | Toronto Blue Jays signed free agent C Luis Meza to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Railin Tejada | — | Toronto Blue Jays | Toronto Blue Jays signed free agent OF Railin Tejada to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Ivan Gonzalez | — | Toronto Blue Jays | Toronto Blue Jays signed free agent RHP Ivan Gonzalez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Jorge Guerra | — | Toronto Blue Jays | Toronto Blue Jays signed free agent RHP Jorge Guerra to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Carlos Meza | — | Toronto Blue Jays | Toronto Blue Jays signed free agent RHP Carlos Meza to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Albert Millan | — | Toronto Blue Jays | Toronto Blue Jays signed free agent C Albert Millan to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Fernando Perez | — | Toronto Blue Jays | Toronto Blue Jays signed free agent RHP Fernando Perez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Omar Romero | — | Toronto Blue Jays | Toronto Blue Jays signed free agent SS Omar Romero to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Luis Torres | — | Toronto Blue Jays | Toronto Blue Jays signed free agent LHP Luis Torres to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Carlos Vasquez | — | Toronto Blue Jays | Toronto Blue Jays signed free agent C Carlos Vasquez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Yhonaider Gudino | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent SS Yhonaider Gudino to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Callum Wallace | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Callum Wallace to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Roinny Aguiar | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent SS Roinny Aguiar to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Hader Blanco | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent LHP Hader Blanco to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Tony Blanco Jr. | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent OF Tony Blanco Jr. to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Angel Camacho | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent LHP Angel Camacho to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Hung-Leng Chang | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent RHP Hung-Leng Chang to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Jarlen De La Paz | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent LHP Jarlen De La Paz to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Yordany De Los Santos | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent SS Yordany De Los Santos to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Daje Morales | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent SS Daje Morales to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Dermis Ordonez | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent RHP Dermis Ordonez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Christopher Orelin | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent SS Christopher Orelin to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Eduardo Oviedo | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent OF Eduardo Oviedo to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Isaac Paulino | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent SS Isaac Paulino to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Axiel Plaz | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent C Axiel Plaz to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Richard Ramirez | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent C Richard Ramirez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Angel Rodriguez | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent OF Angel Rodriguez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Pitterson Rosa | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent RHP Pitterson Rosa to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Alberto Saba | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent RHP Alberto Saba to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Carlos Tirado | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent 1B Carlos Tirado to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Alexis Torres | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent RHP Alexis Torres to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Brayan Sanchez | — | Houston Astros | Houston Astros signed free agent C Brayan Sanchez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Michael Arroyo | — | Seattle Mariners | Seattle Mariners signed free agent SS Michael Arroyo to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Martin Gonzalez | — | Seattle Mariners | Seattle Mariners signed free agent SS Martin Gonzalez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Lazaro Montes | — | Seattle Mariners | Seattle Mariners signed free agent OF Lazaro Montes to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Josue De Paula | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent CF Josue De Paula to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Heison Sanchez | — | Detroit Tigers | Detroit Tigers signed free agent 3B Heison Sanchez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Jeffrey Amparo | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Jeffrey Amparo to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Gabriel Araujo | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent OF Gabriel Araujo to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Albert Carpio | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent SS Albert Carpio to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Jose Colmenarez | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent C Jose Colmenarez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Abdias De La Cruz | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent SS Abdias De La Cruz to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Andy Encarnacion | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent CF Andy Encarnacion to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Abel Fuerte | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Abel Fuerte to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Diego Gonzalez | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent 2B Diego Gonzalez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Cesar Jimenez | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Cesar Jimenez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Moises Lira | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Moises Lira to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Jansel Luis | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent SS Jansel Luis to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Omar Moya | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent C Omar Moya to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Yerald Nin | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent SS Yerald Nin to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Alejandro Rios | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent C Alejandro Rios to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Ruben Santana | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent 3B Ruben Santana to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Cristofer Torin | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent SS Cristofer Torin to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | César Prieto | — | Baltimore Orioles | Baltimore Orioles signed free agent 2B Cesar Prieto to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Roosevelt Trinidad | — | Miami Marlins | Miami Marlins signed free agent RHP Roosevelt Trinidad to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Erick Alvarez | — | Texas Rangers | Texas Rangers signed free agent 2B Erick Alvarez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Robert Perez | — | Miami Marlins | Miami Marlins signed free agent OF Robert Perez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Carlos Pacheco | — | Athletics | Oakland Athletics signed free agent OF Carlos Pacheco to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Ricky Cabrera | — | Cincinnati Reds | Cincinnati Reds signed free agent SS Ricardo Cabrera to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Johan Barrios | — | Milwaukee Brewers | Milwaukee Brewers signed free agent SS Johan Barrios to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Roderick Arias | — | New York Yankees | New York Yankees signed free agent SS Roderick Arias to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | William Bergolla Jr. | — | Philadelphia Phillies | Philadelphia Phillies signed free agent SS William Bergolla to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Dyan Jorge | — | Colorado Rockies | Colorado Rockies signed free agent SS Dyan Jorge to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Natanael Eusebio | — | Boston Red Sox | Boston Red Sox signed free agent CF Natanael Eusebio to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Franklin Lopez | — | Colorado Rockies | Colorado Rockies signed free agent C Franklin Lopez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Echedry Vargas | — | Texas Rangers | Texas Rangers signed free agent 3B Echedry Vargas to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Maikel Hernandez | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP Maikel Hernandez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Anthony Gutierrez | — | Texas Rangers | Texas Rangers signed free agent CF Anthony Gutierrez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Kleimir Lemos | — | Texas Rangers | Texas Rangers signed free agent 3B Kleimer Lemos to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Wilmer Ramirez | — | San Diego Padres | San Diego Padres signed free agent LHP Wilmer Ramirez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Sandy Sanchez | — | Chicago Cubs | Chicago Cubs signed free agent SS Sandy Sanchez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Jhonny Severino | — | Milwaukee Brewers | Milwaukee Brewers signed free agent SS Jhonny Severino to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Yohander Linarez | — | Boston Red Sox | Boston Red Sox signed free agent SS Yohander Linarez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Ricardo Gonzalez | — | Tampa Bay Rays | Tampa Bay Rays signed free agent SS Ricardo Gonzalez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Wellington Aracena | — | New York Mets | New York Mets signed free agent RHP Wellington Aracena to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Rodrigo Romero | — | Tampa Bay Rays | Tampa Bay Rays signed free agent 2B Rodrigo Romero to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Jaiker Garcia | — | Texas Rangers | Texas Rangers signed free agent IF Jaiker Garcia to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Derek Bernard | — | Colorado Rockies | Colorado Rockies signed free agent SS Derek Bernard to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Reminton Batista | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RF Reminton Batista to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Daniel Bruzual | — | Texas Rangers | Texas Rangers signed free agent C Daniel Bruzual to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Ismael Laureano | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP Ismael Laureano to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Jhonny Perez | — | Tampa Bay Rays | Tampa Bay Rays signed free agent C Jhonny Perez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Moises Febrillet | — | Chicago Cubs | Chicago Cubs signed free agent SS Moises Febrillet to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Luis Gonzalez | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RHP Luis Gonzalez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Andelzon Abad | — | Miami Marlins | Miami Marlins signed free agent LHP Andelzon Abad to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Josias Ramirez | — | Chicago Cubs | Chicago Cubs signed free agent OF Josias Ramirez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Denis Reguillo | — | Boston Red Sox | Boston Red Sox signed free agent RHP Dennis Reguillo to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Jhosep Chirinos | — | San Diego Padres | San Diego Padres signed free agent RHP Jhosep Chirinos to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Antony Peguero | — | Miami Marlins | Miami Marlins signed free agent OF Antony Peguero to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Alain Camou | — | San Diego Padres | San Diego Padres signed free agent 2B Alain Camou to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Nestor Chevalier | — | San Diego Padres | San Diego Padres signed free agent 3B Nestor Chevalier to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Maikol Munoz | — | San Diego Padres | San Diego Padres signed free agent SS Maikol Munoz to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Kashon Conliffe | — | San Diego Padres | San Diego Padres signed free agent OF Kashon Conliffe to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Estuar Suero | — | San Diego Padres | San Diego Padres signed free agent OF Estuar Suero to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Josmar Acevedo | — | San Diego Padres | San Diego Padres signed free agent RHP Josmar Acevedo to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Luis Germán | — | San Diego Padres | San Diego Padres signed free agent RHP Luis German to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Francis Peña | — | San Diego Padres | San Diego Padres signed free agent RHP Francis Pena to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Enmanuel Pinales | — | San Diego Padres | San Diego Padres signed free agent RHP Enmanuel Pinales to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Xavier Ruiz | — | San Diego Padres | San Diego Padres signed free agent RHP Xavier Ruiz to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Braian Salazar | — | San Diego Padres | San Diego Padres signed free agent LHP Braian Salazar to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Jefren Tejeda | — | San Diego Padres | San Diego Padres signed free agent LHP Jefren Tejeda to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Francisco Toledo | — | New York Mets | New York Mets signed free agent C Francisco Toledo to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Marcos Herrera | — | Colorado Rockies | Colorado Rockies signed free agent RHP Marcos Herrera to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Willians Romero | — | Colorado Rockies | Colorado Rockies signed free agent RHP Willians Romero to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Kelvin Hidalgo | — | Colorado Rockies | Colorado Rockies signed free agent SS Kelvin HIdalgo to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Roynier Hernandez | — | Colorado Rockies | Colorado Rockies signed free agent SS Roynier Hernandez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Ronny Ugarte | — | Colorado Rockies | Colorado Rockies signed free agent 1B Ronny Ugarte to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Luichi Casilla | — | Colorado Rockies | Colorado Rockies signed free agent LHP Luichi Casilla to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Keider Herrera | — | Colorado Rockies | Colorado Rockies signed free agent RHP Keider Herrera to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Johandry Milano | — | Colorado Rockies | Colorado Rockies signed free agent LHP Johandry Milano to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Doilin Perez | — | Colorado Rockies | Colorado Rockies signed free agent RHP Doilin Perez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Ervin Torres | — | Colorado Rockies | Colorado Rockies signed free agent LHP Ervin Torres to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Cesar Vargas | — | Colorado Rockies | Colorado Rockies signed free agent RHP Cesar Vargas to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Cristian Gonzalez | — | Texas Rangers | Texas Rangers signed free agent SS Cristian Gonzalez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Yeremy Cabrera | — | Texas Rangers | Texas Rangers signed free agent CF Yeremi Cabrera to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Freddy Espinal | — | Texas Rangers | Texas Rangers signed free agent OF Freddy Espinal to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Josefrailin Alcantara | — | Chicago Cubs | Chicago Cubs signed free agent OF Josefrailin Alcantara to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Albert Belliard | — | Chicago Cubs | Chicago Cubs signed free agent OF Albert Belliard to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Jefferson Rojas | — | Chicago Cubs | Chicago Cubs signed free agent SS Jefferson Rojas to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Luis Marquez | — | Texas Rangers | Texas Rangers signed free agent IF Luis Marquez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Jose De Jesus | — | Texas Rangers | Texas Rangers signed free agent OF Jose De Jesus to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Marcos Torres | — | Texas Rangers | Texas Rangers signed free agent OF Marcos Torres to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Freilyn Silverio | — | Chicago Cubs | Chicago Cubs signed free agent RHP Freilyn Silverio to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Darlyn De Leon | — | Chicago Cubs | Chicago Cubs signed free agent 2B Darlyn De Leon to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Alexis Hernandez | — | Chicago Cubs | Chicago Cubs signed free agent SS Alexis Hernandez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Manuel Santana | — | Detroit Tigers | Detroit Tigers signed free agent C Manuel Santana to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Javier Osorio | — | Detroit Tigers | Detroit Tigers signed free agent SS Javier Osorio to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Delvis Matos | — | Detroit Tigers | Detroit Tigers signed free agent OF Delvis Matos to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Junior Quezada | — | Detroit Tigers | Detroit Tigers signed free agent OF Junior Quezada to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Reylin Perez | — | Detroit Tigers | Detroit Tigers signed free agent SS Reylin Perez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Edwar Chirinos | — | Philadelphia Phillies | Philadelphia Phillies signed free agent LHP Edwar Chirinos to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Jeffrey German | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RHP Jeffrey German to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Enrique Segura | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RHP Enrique Segura to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | John Sosa | — | Philadelphia Phillies | Philadelphia Phillies signed free agent LHP John Sosa to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Aroon Escobar | — | Philadelphia Phillies | Philadelphia Phillies signed free agent 3B Aroon Escobar to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Neify Rosario | — | Philadelphia Phillies | Philadelphia Phillies signed free agent OF Neify Rosario to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Denison Sanchez | — | Boston Red Sox | Boston Red Sox signed free agent RHP Denison Sanchez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Nolan Beltran | — | Philadelphia Phillies | Philadelphia Phillies signed free agent SS Nolan Beltran to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Leny Carela | — | Philadelphia Phillies | Philadelphia Phillies signed free agent SS Leny Carela to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Kilwer Colmenares | — | Philadelphia Phillies | Philadelphia Phillies signed free agent SS Kilwer Colmenares to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Juan Villavicencio | — | Philadelphia Phillies | Philadelphia Phillies signed free agent SS Juan Villavicencio to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Manolfi Jimenez | — | Philadelphia Phillies | Philadelphia Phillies signed free agent OF Manolfi Jimenez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Romel Mendez | — | Philadelphia Phillies | Philadelphia Phillies signed free agent OF Romel Mendez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Alvaro Gamez | — | Tampa Bay Rays | Tampa Bay Rays signed free agent LHP Alvaro Gamez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Cristhofer Gonzalez | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP Cristhofer Gonzalez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Yeison Garcia | — | Tampa Bay Rays | Tampa Bay Rays signed free agent LHP Yeison Garcia to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Moises Palma | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP Moises Palma to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Jorman Primera | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP Jorman Primera to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Geudis Ramos | — | Tampa Bay Rays | Tampa Bay Rays signed free agent LHP Geudis Ramos to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Jesus Ullola | — | Tampa Bay Rays | Tampa Bay Rays signed free agent LHP Jesus Ullola to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Nicandro Aybar | — | Tampa Bay Rays | Tampa Bay Rays signed free agent 3B Nicandro Aybar to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Felix Cotes | — | Tampa Bay Rays | Tampa Bay Rays signed free agent 2B Felix Cotes to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Angel Mateo | — | Tampa Bay Rays | Tampa Bay Rays signed free agent OF Angel Mateo to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Jordany Oliver | — | Tampa Bay Rays | Tampa Bay Rays signed free agent 3B Jordany Oliver to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Danny Hilario | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP Danny Hilario to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Anthony Manriquez | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP Anthony Manriquez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Enderson Delgado | — | Tampa Bay Rays | Tampa Bay Rays signed free agent C Enderson Delgado to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Larry Martinez | — | Tampa Bay Rays | Tampa Bay Rays signed free agent 3B Larry Martinez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Juanfel Peguero | — | Tampa Bay Rays | Tampa Bay Rays signed free agent 2B Juanfel Peguero to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Narciso Polanco | — | Tampa Bay Rays | Tampa Bay Rays signed free agent 2B Narciso Polanco to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Roosbert Tapia | — | Tampa Bay Rays | Tampa Bay Rays signed free agent 2B Roosbert Tapia to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Jose Contreras | — | Tampa Bay Rays | Tampa Bay Rays signed free agent OF Jose Contreras to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Jose Sanabria | — | Tampa Bay Rays | Tampa Bay Rays signed free agent OF Jose Sanabria to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Yorman Galindez | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Yorman Galindez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Joneiker Arellano | — | Cincinnati Reds | Cincinnati Reds signed free agent RHP Joneiker Arellano to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Lisnerkin Lantigua | — | Cincinnati Reds | Cincinnati Reds signed free agent RHP Lisnerkin Lantigua to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | David Lorduy | — | Cincinnati Reds | Cincinnati Reds signed free agent RHP David Lorduy to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Nelfri Payano | — | Cincinnati Reds | Cincinnati Reds signed free agent RHP Nelfri Payano to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Henry Guerrero | — | Cincinnati Reds | Cincinnati Reds signed free agent C Henry Guerrero to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Jesus Correa | — | Cincinnati Reds | Cincinnati Reds signed free agent SS Jesus Correa to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Anthuan Valencia | — | Cincinnati Reds | Cincinnati Reds signed free agent SS Anthuan Valencia to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Esmith Pineda | — | Cincinnati Reds | Cincinnati Reds signed free agent OF Esmith Pineda to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Adrian Reyes | — | Cincinnati Reds | Cincinnati Reds signed free agent OF Adrian Reyes to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Carlos Sanchez | — | Cincinnati Reds | Cincinnati Reds signed free agent OF Carlos Sanchez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Franyer Herrera | — | New York Yankees | New York Yankees signed free agent LHP Franyer Herrera to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Diomedes Hernandez | — | New York Yankees | New York Yankees signed free agent C Diomedes Hernandez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Ricardo Rodriguez | — | New York Yankees | New York Yankees signed free agent C Ricardo Rodriguez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Abrahan Ramirez | — | New York Yankees | New York Yankees signed free agent SS Abrahan Ramirez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Louis Pierre | — | New York Yankees | New York Yankees signed free agent CF Louis Pierre to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Omar Gonzalez | — | New York Yankees | New York Yankees signed free agent RHP Omar Gonzalez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Diego Hernandez | — | New York Yankees | New York Yankees signed free agent RHP Diego Hernandez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Engelth Urena | — | New York Yankees | New York Yankees signed free agent C Engelth Urena to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Luis Suarez | — | New York Yankees | New York Yankees signed free agent SS Luis Suarez to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Enmanuel Tejeda | — | New York Yankees | New York Yankees signed free agent SS Enmanuel Tejeda to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Enmanuel Tejeda | — | New York Yankees | New York Yankees signed free agent SS Enmanuel Tejeda to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | John Cruz | — | New York Yankees | New York Yankees signed free agent CF John Cruz to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Jose Felipe Torres | — | Texas Rangers | Texas Rangers signed free agent RHP Jose Felipe Torres to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Luis Garcia | — | Milwaukee Brewers | Milwaukee Brewers signed free agent C Luis Garcia to a minor league contract. |
| Jan 15, 2022 | Signed as free agent | Alfredo Espinoza | — | Texas Rangers | Texas Rangers signed free agent C Alfredo Espinoza to a minor league contract. |
| Jan 13, 2022 | Signed as free agent | Justin Maese | — | Atlanta Braves | Atlanta Braves signed free agent RHP Justin Maese to a minor league contract. |
| Jan 12, 2022 | Signed as free agent | Ryder Jones | — | Chicago White Sox | Chicago White Sox signed free agent 1B Ryder Jones to a minor league contract. |
| Jan 12, 2022 | Signed as free agent | Magneuris Sierra | — | Los Angeles Angels | Los Angeles Angels signed free agent RF Magneuris Sierra to a minor league contract. |
| Jan 12, 2022 | Signed as free agent | Matt Mullenbach | — | Minnesota Twins | Minnesota Twins signed free agent RHP Matt Mullenbach to a minor league contract. |
| Jan 12, 2022 | Signed as free agent | Chris Mazza | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP Chris Mazza to a minor league contract. |
| Jan 12, 2022 | Signed as free agent | Trey Hair | — | Texas Rangers | Texas Rangers signed free agent 2B Trey Hair to a minor league contract. |
| Jan 12, 2022 | Signed as free agent | Arodys Vizcaíno | — | Kansas City Royals | Kansas City Royals signed free agent RHP Arodys Vizcaino to a minor league contract. |
| Jan 11, 2022 | Signed as free agent | Juniel Querecuto | — | Cincinnati Reds | Cincinnati Reds signed free agent 3B Juniel Querecuto to a minor league contract and invited him to spring training. |
| Jan 11, 2022 | Signed as free agent | Dereck Rodríguez | — | Minnesota Twins | Minnesota Twins signed free agent RHP Dereck Rodriguez to a minor league contract. |
| Jan 11, 2022 | Signed as free agent | Jacob Coats | — | Houston Astros | Houston Astros signed free agent RHP Jacob Coats to a minor league contract. |
| Jan 11, 2022 | Signed as free agent | Michael Tonkin | — | Atlanta Braves | Atlanta Braves signed free agent RHP Michael Tonkin to a minor league contract. |
| Jan 10, 2022 | Signed as free agent | Jesus Linarez | — | Texas Rangers | Texas Rangers signed free agent RHP Jesus Linarez to a minor league contract. |
| Jan 10, 2022 | Signed as free agent | Tyler White | — | Milwaukee Brewers | Milwaukee Brewers signed free agent 1B Tyler White to a minor league contract. |
| Jan 10, 2022 | Signed as free agent | Collin Hopkins | — | Minnesota Twins | Minnesota Twins signed free agent C Collin Hopkins to a minor league contract. |
| Jan 10, 2022 | Signed as free agent | Brian Gonzalez | — | Washington Nationals | Washington Nationals signed free agent LHP Brian Gonzalez to a minor league contract. |
| Jan 9, 2022 | Signed as free agent | Nick Duron | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RHP Nick Duron to a minor league contract. |
| Jan 8, 2022 | Signed as free agent | Alex Claudio | — | New York Mets | New York Mets signed free agent LHP Alex Claudio to a minor league contract. |
| Jan 8, 2022 | Signed as free agent | Jake Lemoine | — | Athletics | Oakland Athletics signed free agent RHP Jacob Lemoine to a minor league contract. |
| Jan 8, 2022 | Signed as free agent | Rusney Castillo | — | Washington Nationals | Washington Nationals signed free agent RF Rusney Castillo to a minor league contract. |
| Jan 8, 2022 | Signed as free agent | Ramon Santos | — | Washington Nationals | Washington Nationals signed free agent RHP Ramon Santos to a minor league contract. |
| Jan 8, 2022 | Signed as free agent | Alex Rodriguez | — | Minnesota Twins | Minnesota Twins signed free agent C Alex Rodriguez to a minor league contract. |
| Jan 7, 2022 | Signed as free agent | Joey Meneses | — | Washington Nationals | Washington Nationals signed free agent 1B Joey Meneses to a minor league contract. |
| Jan 7, 2022 | Signed as free agent | Jorger Petri | — | Detroit Tigers | Detroit Tigers signed free agent LHP Jorger Petri to a minor league contract. |
| Jan 6, 2022 | Signed as free agent | Ben Lively | — | Cincinnati Reds | Cincinnati Reds signed free agent RHP Ben Lively to a minor league contract and invited him to spring training. |
| Jan 4, 2022 | Signed as free agent | Johan Mieses | — | Boston Red Sox | Boston Red Sox signed free agent CF Johan Mieses to a minor league contract. |
| Jan 4, 2022 | Signed as free agent | Huascar Brazobán | — | Miami Marlins | Miami Marlins signed free agent RHP Huascar Brazoban to a minor league contract. |
| Jan 4, 2022 | Signed as free agent | Aldrem Corredor | — | Philadelphia Phillies | Philadelphia Phillies signed free agent 1B Aldrem Corredor to a minor league contract. |
| Jan 4, 2022 | Signed as free agent | Kevin Vicuña | — | Philadelphia Phillies | Philadelphia Phillies signed free agent SS Kevin Vicuna to a minor league contract. |
| Jan 4, 2022 | Signed as free agent | Angel Felipe | — | San Diego Padres | San Diego Padres signed free agent RHP Angel Felipe to a minor league contract. |
| Jan 4, 2022 | Signed as free agent | Aderlin Rodríguez | — | San Diego Padres | San Diego Padres signed free agent 3B Aderlin Rodriguez to a minor league contract. |
| Jan 4, 2022 | Signed as free agent | Luis Madrazo | — | San Diego Padres | San Diego Padres signed free agent RHP Luis Madrazo to a minor league contract. |
| Jan 4, 2022 | Signed as free agent | Orlando Rodriguez | — | Minnesota Twins | Minnesota Twins signed free agent RHP Orlando Rodriguez to a minor league contract. |
| Jan 4, 2022 | Signed as free agent | Mario Sanchez | — | Minnesota Twins | Minnesota Twins signed free agent RHP Mario Sanchez to a minor league contract. |
| Jan 4, 2022 | Signed as free agent | Kennie Taylor | — | Minnesota Twins | Minnesota Twins signed free agent CF Kennie Taylor to a minor league contract. |
| Jan 3, 2022 | Signed as free agent | Drew Stankiewicz | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent 2B Drew Stankiewicz to a minor league contract. |
| Jan 2, 2022 | Signed as free agent | Jeferson Lopez | — | Minnesota Twins | Minnesota Twins signed free agent RHP Jeferson Lopez to a minor league contract. |
Every row is captured from MLB’s official StatsAPI transactions feed with MLB’s published description unedited. Signings include both major-league and minor-league contracts signed with a major-league club; injury-list moves and minor-league affiliate-only transactions are outside this archive’s scope.
Transaction data: official MLB StatsAPI. Data provided by MLB Advanced Media. Archived and published by Legends Deck.