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The 2021 season’s official transaction log: 3,406 trades, signings and releases involving major-league clubs, listed newest first with MLB’s own description of each move.
| Date | Type | Player | From | To | Details |
|---|---|---|---|---|---|
| Dec 29, 2021 | Signed as free agent | Dixon Machado | — | Chicago Cubs | Chicago Cubs signed free agent 2B Dixon Machado to a minor league contract. |
| Dec 22, 2021 | Signed as free agent | Roby Enriquez | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RF Roby Enriquez to a minor league contract. |
| Dec 22, 2021 | Signed as free agent | Mitch Miller | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent LHP Mitchell Miller to a minor league contract. |
| Dec 22, 2021 | Signed as free agent | Seth Mejias-Brean | — | Seattle Mariners | Seattle Mariners signed free agent 3B Seth Mejias-Brean to a minor league contract. |
| Dec 22, 2021 | Signed as free agent | Diomar Lopez | — | Cincinnati Reds | Cincinnati Reds signed free agent RHP Diomar Lopez to a minor league contract. |
| Dec 21, 2021 | Signed as free agent | Rob Refsnyder | — | Boston Red Sox | Boston Red Sox signed free agent 2B Rob Refsnyder to a minor league contract and invited him to spring training. |
| Dec 21, 2021 | Signed as free agent | Terry McClure | — | Seattle Mariners | Seattle Mariners signed free agent CF Terry McClure to a minor league contract. |
| Dec 21, 2021 | Signed as free agent | Edwin Díaz | — | Houston Astros | Houston Astros signed free agent 3B Edwin Diaz to a minor league contract and invited him to spring training. |
| Dec 21, 2021 | Signed as free agent | Jon Singleton | — | Milwaukee Brewers | Milwaukee Brewers signed free agent 1B Jon Singleton to a minor league contract. |
| Dec 21, 2021 | Signed as free agent | Unnamed | — | Cincinnati Reds | Cincinnati Reds signed free agent RF Isiah Gilliam and to a minor league contract. |
| Dec 20, 2021 | Signed as free agent | Jake Bauers | — | Cincinnati Reds | Cincinnati Reds signed free agent DH Jake Bauers to a minor league contract and invited him to spring training. |
| Dec 20, 2021 | Signed as free agent | Matt Cleveland | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Matt Cleveland to a minor league contract. |
| Dec 18, 2021 | Signed as free agent | Tony Wolters | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent C Tony Wolters to a minor league contract. |
| Dec 18, 2021 | Signed as free agent | Mitch Longo | — | Washington Nationals | Washington Nationals signed free agent LF Mitch Longo to a minor league contract. |
| Dec 17, 2021 | Signed as free agent | Yefry Ramírez | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Yefry Ramirez to a minor league contract and invited him to spring training. |
| Dec 17, 2021 | Signed as free agent | Jose Gomez | — | Los Angeles Angels | Los Angeles Angels signed free agent 3B Jose Gomez to a minor league contract. |
| Dec 16, 2021 | Signed as free agent | Gosuke Katoh | — | Toronto Blue Jays | Toronto Blue Jays signed free agent 2B Gosuke Katoh to a minor league contract. |
| Dec 16, 2021 | Signed as free agent | Wladimir Pinto | — | Minnesota Twins | Minnesota Twins signed free agent RHP Wladimir Pinto to a minor league contract. |
| Dec 16, 2021 | Signed as free agent | Dennis Ortega | — | Minnesota Twins | Minnesota Twins signed free agent C Dennis Ortega to a minor league contract. |
| Dec 15, 2021 | Signed as free agent | Mark Leiter Jr. | — | Chicago Cubs | Chicago Cubs signed free agent RHP Mark Leiter Jr. to a minor league contract. |
| Dec 15, 2021 | Signed as free agent | Kyle Holder | — | Colorado Rockies | Colorado Rockies signed free agent SS Kyle Holder to a minor league contract. |
| Dec 15, 2021 | Signed as free agent | Tim Lopes | — | Colorado Rockies | Colorado Rockies signed free agent 2B Tim Lopes to a minor league contract. |
| Dec 15, 2021 | Signed as free agent | D.J. Burt | — | Chicago White Sox | Chicago White Sox signed free agent 2B D.J. Burt to a minor league contract. |
| Dec 15, 2021 | Signed as free agent | Brandon Finnegan | — | Chicago White Sox | Chicago White Sox signed free agent LHP Brandon Finnegan to a minor league contract. |
| Dec 15, 2021 | Signed as free agent | Ryan Aguilar | — | Los Angeles Angels | Los Angeles Angels signed free agent LF Ryan Aguilar to a minor league contract. |
| Dec 15, 2021 | Signed as free agent | Ivan Castillo | — | Kansas City Royals | Kansas City Royals signed free agent SS Ivan Castillo to a minor league contract. |
| Dec 15, 2021 | Signed as free agent | Luis Aviles Jr. | — | Miami Marlins | Miami Marlins signed free agent SS Luis Aviles Jr. to a minor league contract. |
| Dec 15, 2021 | Signed as free agent | Moises Gomez | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Moises Gomez to a minor league contract. |
| Dec 15, 2021 | Signed as free agent | Arnaldo Hernandez | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Arnaldo Hernandez to a minor league contract. |
| Dec 15, 2021 | Signed as free agent | Jakson Reetz | — | Milwaukee Brewers | Milwaukee Brewers signed free agent C Jakson Reetz to a minor league contract. |
| Dec 15, 2021 | Signed as free agent | Garrett Whitley | — | Milwaukee Brewers | Milwaukee Brewers signed free agent CF Garrett Whitley to a minor league contract. |
| Dec 15, 2021 | Signed as free agent | Leobaldo Cabrera | — | Minnesota Twins | Minnesota Twins signed free agent RF Leobaldo Cabrera to a minor league contract. |
| Dec 15, 2021 | Signed as free agent | Derek Fisher | — | Minnesota Twins | Minnesota Twins signed free agent LF Derek Fisher to a minor league contract. |
| Dec 15, 2021 | Signed as free agent | Zaquiel Puentes | — | Minnesota Twins | Minnesota Twins signed free agent RHP Zaquiel Puentes to a minor league contract. |
| Dec 15, 2021 | Signed as free agent | Samuel Perez | — | Minnesota Twins | Minnesota Twins signed free agent LHP Samuel Perez to a minor league contract. |
| Dec 15, 2021 | Signed as free agent | Wilkerman Garcia | — | New York Yankees | New York Yankees signed free agent SS Wilkerman Garcia to a minor league contract. |
| Dec 15, 2021 | Signed as free agent | Ender Inciarte | — | New York Yankees | New York Yankees signed free agent CF Ender Inciarte to a minor league contract. |
| Dec 15, 2021 | Signed as free agent | Vinny Nittoli | — | New York Yankees | New York Yankees signed free agent RHP Vinny Nittoli to a minor league contract. |
| Dec 15, 2021 | Signed as free agent | Blake Perkins | — | New York Yankees | New York Yankees signed free agent CF Blake Perkins to a minor league contract. |
| Dec 15, 2021 | Signed as free agent | Enmanuel De Jesus | — | San Francisco Giants | San Francisco Giants signed free agent LHP Enmanuel De Jesus to a minor league contract. |
| Dec 15, 2021 | Signed as free agent | Jhonny Pereda | — | San Francisco Giants | San Francisco Giants signed free agent C Jhonny Pereda to a minor league contract. |
| Dec 15, 2021 | Signed as free agent | Yariel Gonzalez | — | Atlanta Braves | Atlanta Braves signed free agent 3B Yariel Gonzalez to a minor league contract. |
| Dec 15, 2021 | Signed as free agent | Jimmy Cordero | — | New York Yankees | New York Yankees signed free agent RHP Jimmy Cordero to a minor league contract. |
| Dec 15, 2021 | Signed as free agent | Rodolfo Durán | — | New York Yankees | New York Yankees signed free agent C Rodolfo Duran to a minor league contract. |
| Dec 15, 2021 | Signed as free agent | Luke Westphal | — | San Diego Padres | San Diego Padres signed free agent LHP Luke Westphal to a minor league contract. |
| Dec 15, 2021 | Signed as free agent | Bryan Brickhouse | — | San Francisco Giants | San Francisco Giants signed free agent RHP Bryan Brickhouse to a minor league contract. |
| Dec 15, 2021 | Signed as free agent | Santiago Ramirez | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Santiago Ramirez to a minor league contract. |
| Dec 15, 2021 | Signed as free agent | Luis De León | — | Baltimore Orioles | Baltimore Orioles signed free agent LHP Luis De Leon to a minor league contract. |
| Dec 15, 2021 | Signed as free agent | Yu-Min Lin | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent LHP Yu-Min Lin to a minor league contract. |
| Dec 15, 2021 | Signed as free agent | Jorge Herrera | — | Kansas City Royals | Kansas City Royals signed free agent RHP Jorge Herrera to a minor league contract. |
| Dec 14, 2021 | Signed as free agent | Oliver Carrillo | — | San Diego Padres | San Diego Padres signed free agent OF Oliver Carrillo to a minor league contract. |
| Dec 14, 2021 | Signed as free agent | Matt Vogel | — | Baltimore Orioles | Baltimore Orioles signed free agent RHP Matt Vogel to a minor league contract. |
| Dec 14, 2021 | Signed as free agent | David Freitas | — | New York Yankees | New York Yankees signed free agent C David Freitas to a minor league contract. |
| Dec 14, 2021 | Signed as free agent | Domingo Leyba | — | San Diego Padres | San Diego Padres signed free agent SS Domingo Leyba to a minor league contract. |
| Dec 14, 2021 | Signed as free agent | Christian Montes De Oca | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Christian Montes De Oca to a minor league contract. |
| Dec 14, 2021 | Signed as free agent | Alfred Morillo | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Alfred Morillo to a minor league contract. |
| Dec 14, 2021 | Signed as free agent | Wilmer Blanco | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RHP Wilmer Blanco to a minor league contract. |
| Dec 14, 2021 | Signed as free agent | Lazaro Morales | — | San Francisco Giants | San Francisco Giants signed free agent OF Lazaro Morales to a minor league contract. |
| Dec 13, 2021 | Signed as free agent | Emmanuel Martinez | — | Texas Rangers | Texas Rangers signed free agent LHP Emmanuel Martinez to a minor league contract. |
| Dec 13, 2021 | Signed as free agent | Claudio Simon | — | Boston Red Sox | Boston Red Sox signed free agent 2B Claudio Simon to a minor league contract. |
| Dec 13, 2021 | Signed as free agent | Frank Pena | — | Texas Rangers | Texas Rangers signed free agent CF Frank Pena to a minor league contract. |
| Dec 13, 2021 | Signed as free agent | Rancer Adon | — | Texas Rangers | Texas Rangers signed free agent RHP Rancer Adon to a minor league contract. |
| Dec 13, 2021 | Signed as free agent | Francisco Romero | — | Atlanta Braves | Atlanta Braves signed free agent RHP Francisco Romero to a minor league contract. |
| Dec 13, 2021 | Signed as free agent | Luis Ledo | — | Los Angeles Angels | Los Angeles Angels signed free agent RHP Luis Ledo to a minor league contract. |
| Dec 13, 2021 | Signed as free agent | Dillon Thomas | — | Los Angeles Angels | Los Angeles Angels signed free agent LF Dillon Thomas to a minor league contract. |
| Dec 13, 2021 | Signed as free agent | Daniel Palka | — | New York Mets | New York Mets signed free agent LF Daniel Palka to a minor league contract. |
| Dec 13, 2021 | Signed as free agent | Jason Krizan | — | San Francisco Giants | San Francisco Giants signed free agent LF Jason Krizan to a minor league contract. |
| Dec 12, 2021 | Signed as free agent | Maikel Franco | — | Washington Nationals | Washington Nationals signed free agent 3B Maikel Franco to a minor league contract. |
| Dec 12, 2021 | Signed as free agent | Dee Strange-Gordon | — | Washington Nationals | Washington Nationals signed free agent 2B Dee Strange-Gordon to a minor league contract. |
| Dec 11, 2021 | Signed as free agent | Osmy Gregorio | — | Los Angeles Angels | Los Angeles Angels signed free agent 2B Osmy Gregorio to a minor league contract. |
| Dec 10, 2021 | Signed as free agent | Clayton Campbell | — | Detroit Tigers | Detroit Tigers signed free agent 3B Clayton Campbell to a minor league contract. |
| Dec 10, 2021 | Signed as free agent | Jaycey Benita | — | New York Mets | New York Mets signed free agent OF Jaycey Benita to a minor league contract. |
| Dec 10, 2021 | Signed as free agent | Luis Bermudez | — | San Francisco Giants | San Francisco Giants signed free agent RHP Luis Bermudez to a minor league contract. |
| Dec 10, 2021 | Signed as free agent | Moises Gonzalez | — | San Francisco Giants | San Francisco Giants signed free agent RHP Moises Gonzalez to a minor league contract. |
| Dec 10, 2021 | Signed as free agent | Arlison Rodriguez | — | New York Mets | New York Mets signed free agent LHP Arlison Rodriguez to a minor league contract. |
| Dec 10, 2021 | Signed as free agent | Tyler Cyr | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RHP Tyler Cyr to a minor league contract. |
| Dec 10, 2021 | Signed as free agent | Joe Gatto | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RHP Joe Gatto to a minor league contract. |
| Dec 10, 2021 | Signed as free agent | Wendell Rijo | — | Philadelphia Phillies | Philadelphia Phillies signed free agent 2B Wendell Rijo to a minor league contract. |
| Dec 10, 2021 | Signed as free agent | Matthew Swilley | — | San Diego Padres | San Diego Padres signed free agent RHP Matthew Swilley to a minor league contract. |
| Dec 9, 2021 | Signed as free agent | Kyle Dowdy | — | Cincinnati Reds | Cincinnati Reds signed free agent RHP Kyle Dowdy to a minor league contract and invited him to spring training. |
| Dec 9, 2021 | Signed as free agent | Tomás Telis | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent C Tomas Telis to a minor league contract. |
| Dec 9, 2021 | Signed as free agent | Jake Newberry | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RHP Jake Newberry to a minor league contract. |
| Dec 9, 2021 | Signed as free agent | Bobby Milacki | — | Minnesota Twins | Minnesota Twins signed free agent RHP Bobby Milacki to a minor league contract. |
| Dec 8, 2021 | Signed as free agent | Yoelin Disla | — | New York Mets | New York Mets signed free agent RHP Yoelin Disla to a minor league contract. |
| Dec 8, 2021 | Signed as free agent | Ali Castillo | — | Philadelphia Phillies | Philadelphia Phillies signed free agent SS Ali Castillo to a minor league contract. |
| Dec 8, 2021 | Signed as free agent | Carson Fulmer | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Carson Fulmer to a minor league contract and invited him to spring training. |
| Dec 8, 2021 | Trade | Tanner Andrews | Atlanta Braves | San Francisco Giants | Atlanta Braves traded RHP Tanner Andrews to San Francisco Giants. |
| Dec 7, 2021 | Signed as free agent | Darwin Caballero | — | Baltimore Orioles | Baltimore Orioles signed free agent RHP Darwin Caballero to a minor league contract. |
| Dec 7, 2021 | Signed as free agent | Noelin Cuevas | — | Baltimore Orioles | Baltimore Orioles signed free agent LHP Noelin Cuevas to a minor league contract. |
| Dec 7, 2021 | Signed as free agent | Raynel Duran | — | Baltimore Orioles | Baltimore Orioles signed free agent RHP Raynel Duran to a minor league contract. |
| Dec 7, 2021 | Signed as free agent | Wilton Rondon | — | Baltimore Orioles | Baltimore Orioles signed free agent RHP Wilton Rondon to a minor league contract. |
| Dec 7, 2021 | Signed as free agent | Kevin Gadea | — | New York Mets | New York Mets signed free agent RHP Kevin Gadea to a minor league contract. |
| Dec 6, 2021 | Signed as free agent | Jarlin Guerrero | — | Baltimore Orioles | Baltimore Orioles signed free agent RHP Jarlin Guerrero to a minor league contract. |
| Dec 6, 2021 | Signed as free agent | Eliazar De Los Santos | — | Athletics | Oakland Athletics signed free agent RHP Eliazar De Los Santos to a minor league contract. |
| Dec 6, 2021 | Signed as free agent | Jose Fleury | — | Houston Astros | Houston Astros signed free agent RHP Jose Fleury to a minor league contract. |
| Dec 6, 2021 | Signed as free agent | Isaac Pena | — | Minnesota Twins | Minnesota Twins signed free agent IF Isaac Pena to a minor league contract. |
| Dec 6, 2021 | Signed as free agent | Javier Roman | — | Minnesota Twins | Minnesota Twins signed free agent C Javier Roman to a minor league contract. |
| Dec 6, 2021 | Signed as free agent | Jose S. Mendoza | — | Chicago White Sox | Chicago White Sox signed free agent RHP Jose Mendoza to a minor league contract. |
| Dec 6, 2021 | Signed as free agent | Ronny Robles | — | Chicago White Sox | Chicago White Sox signed free agent RHP Ronny Robles to a minor league contract. |
| Dec 6, 2021 | Signed as free agent | Jesus Vargas | — | New York Mets | New York Mets signed free agent RHP Jesus Vargas to a minor league contract. |
| Dec 6, 2021 | Signed as free agent | Bryan Bautista | — | Baltimore Orioles | Baltimore Orioles signed free agent RHP Bryan Bautista to a minor league contract. |
| Dec 5, 2021 | Signed as free agent | Eliecer Bata | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RHP Eliecer Bata to a minor league contract. |
| Dec 5, 2021 | Signed as free agent | Dariam Gutierrez | — | Philadelphia Phillies | Philadelphia Phillies signed free agent OF Dariam Gutierrez to a minor league contract. |
| Dec 4, 2021 | Signed as free agent | Luis Flores | — | Cleveland Guardians | Cleveland Guardians signed free agent LHP Luis Flores to a minor league contract. |
| Dec 3, 2021 | Signed as free agent | Jalen Miller | — | Atlanta Braves | Atlanta Braves signed free agent 2B Jalen Miller to a minor league contract. |
| Dec 3, 2021 | Signed as free agent | Stephen Gonsalves | — | Chicago Cubs | Chicago Cubs signed free agent LHP Stephen Gonsalves to a minor league contract. |
| Dec 3, 2021 | Signed as free agent | Yacksel Ríos | — | Chicago White Sox | Chicago White Sox signed free agent RHP Yacksel Rios to a minor league contract. |
| Dec 3, 2021 | Signed as free agent | Matthew Kent | — | Miami Marlins | Miami Marlins signed free agent LHP Matthew Kent to a minor league contract. |
| Dec 3, 2021 | Signed as free agent | Drew Jackson | — | Athletics | Oakland Athletics signed free agent SS Drew Jackson to a minor league contract. |
| Dec 3, 2021 | Signed as free agent | Dalton Kelly | — | Athletics | Oakland Athletics signed free agent 1B Dalton Kelly to a minor league contract. |
| Dec 3, 2021 | Signed as free agent | Brian O'Keefe | — | Seattle Mariners | Seattle Mariners signed free agent C Brian O'Keefe to a minor league contract. |
| Dec 3, 2021 | Signed as free agent | Jon Duplantier | — | San Francisco Giants | San Francisco Giants signed free agent RHP Jon Duplantier to a minor league contract. |
| Dec 3, 2021 | Signed as free agent | Gray Fenter | — | San Francisco Giants | San Francisco Giants signed free agent RHP Gray Fenter to a minor league contract. |
| Dec 3, 2021 | Signed as free agent | Mauricio Llovera | — | San Francisco Giants | San Francisco Giants signed free agent RHP Mauricio Llovera to a minor league contract. |
| Dec 3, 2021 | Signed as free agent | Jorge Avendano | — | New York Mets | New York Mets signed free agent LHP Jorge Avendano to a minor league contract. |
| Dec 2, 2021 | Signed as free agent | Germain Noriega | — | New York Mets | New York Mets signed free agent OF Germain Noriega to a minor league contract. |
| Dec 2, 2021 | Signed as free agent | Richard Cardoza | — | New York Mets | New York Mets signed free agent LHP Richard Cardoza to a minor league contract. |
| Dec 1, 2021 | Trade | Jorge Alfaro | Miami Marlins | San Diego Padres | Miami Marlins traded C Jorge Alfaro to San Diego Padres. |
| Dec 1, 2021 | Signed as free agent | Daniel Hudson | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Daniel Hudson. |
| Dec 1, 2021 | Signed as free agent | Héctor Neris | — | Houston Astros | Houston Astros signed free agent RHP Hector Neris. |
| Dec 1, 2021 | Signed as free agent | Kevin Gausman | — | Toronto Blue Jays | Toronto Blue Jays signed free agent RHP Kevin Gausman. |
| Dec 1, 2021 | Signed as free agent | Marcus Semien | — | Texas Rangers | Texas Rangers signed free agent SS Marcus Semien. |
| Dec 1, 2021 | Signed as free agent | Corey Kluber | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP Corey Kluber. |
| Dec 1, 2021 | Signed as free agent | Avisaíl García | — | Miami Marlins | Miami Marlins signed free agent RF Avisail Garcia. |
| Dec 1, 2021 | Signed as free agent | Max Scherzer | — | New York Mets | New York Mets signed free agent RHP Max Scherzer. |
| Dec 1, 2021 | Signed as free agent | Yimi García | — | Toronto Blue Jays | Toronto Blue Jays signed free agent RHP Yimi Garcia. |
| Dec 1, 2021 | Signed as free agent | Leury García | — | Chicago White Sox | Chicago White Sox signed free agent CF Leury Garcia. |
| Dec 1, 2021 | Signed as free agent | Unnamed | — | San Francisco Giants | San Francisco Giants signed free agent LHP Alex Wood, and. |
| Dec 1, 2021 | Signed as free agent | Yan Gomes | — | Chicago Cubs | Chicago Cubs signed free agent C Yan Gomes. |
| Dec 1, 2021 | Signed as free agent | Roberto Pérez | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent C Roberto Perez. |
| Dec 1, 2021 | Signed as free agent | Corey Knebel | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RHP Corey Knebel. |
| Dec 1, 2021 | Signed as free agent | Eduardo Escobar | — | New York Mets | New York Mets signed free agent 3B Eduardo Escobar. |
| Dec 1, 2021 | Signed as free agent | Corey Seager | — | Texas Rangers | Texas Rangers signed free agent SS Corey Seager. |
| Dec 1, 2021 | Signed as free agent | Enyel De Los Santos | — | Cleveland Guardians | Cleveland Guardians signed free agent RHP Enyel De Los Santos to a minor league contract and invited him to spring training. |
| Dec 1, 2021 | Signed as free agent | Unnamed | — | Detroit Tigers | Detroit Tigers signed free agent SS Javier Baez, and. |
| Dec 1, 2021 | Signed as free agent | Richard Lovelady | — | Kansas City Royals | Kansas City Royals signed free agent LHP Richard Lovelady to a minor league contract. |
| Dec 1, 2021 | Signed as free agent | JaCoby Jones | — | Kansas City Royals | Kansas City Royals signed free agent CF JaCoby Jones to a minor league contract. |
| Dec 1, 2021 | Signed as free agent | Mark Melancon | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Mark Melancon. |
| Dec 1, 2021 | Signed as free agent | Luis García | — | San Diego Padres | San Diego Padres signed free agent RHP Luis Garcia. |
| Dec 1, 2021 | Signed as free agent | Dylan Bundy | — | Minnesota Twins | Minnesota Twins signed free agent RHP Dylan Bundy. |
| Dec 1, 2021 | Signed as free agent | Jon Gray | — | Texas Rangers | Texas Rangers signed free agent RHP Jon Gray. |
| Dec 1, 2021 | Signed as free agent | Yohel Pozo | — | Texas Rangers | Texas Rangers signed free agent C Yohel Pozo and to a minor league contract and invited him to spring training. |
| Dec 1, 2021 | Signed as free agent | David García | — | Texas Rangers | Texas Rangers signed free agent C David Garcia to a minor league contract and invited him to spring training. |
| Dec 1, 2021 | Signed as free agent | Jesus Tinoco | — | Texas Rangers | Texas Rangers signed free agent RHP Jesus Tinoco to a minor league contract and invited him to spring training. |
| Dec 1, 2021 | Signed as free agent | Meibrys Viloria | — | Texas Rangers | Texas Rangers signed free agent C Meibrys Viloria to a minor league contract and invited him to spring training. |
| Dec 1, 2021 | Signed as free agent | Clint Frazier | — | Chicago Cubs | Chicago Cubs signed free agent LF Clint Frazier. |
| Dec 1, 2021 | Signed as free agent | Johan Camargo | — | Philadelphia Phillies | Philadelphia Phillies signed free agent 3B Johan Camargo. |
| Dec 1, 2021 | Signed as free agent | Michael Hermosillo | — | Chicago Cubs | Chicago Cubs signed free agent RF Michael Hermosillo. |
| Dec 1, 2021 | Signed as free agent | Chris Taylor | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent SS Chris Taylor. |
| Dec 1, 2021 | Signed as free agent | Raisel Iglesias | — | Los Angeles Angels | Los Angeles Angels signed free agent RHP Raisel Iglesias. |
| Dec 1, 2021 | Signed as free agent | Robert Suarez | — | San Diego Padres | San Diego Padres signed free agent RHP Robert Suarez. |
| Dec 1, 2021 | Signed as free agent | Marcus Stroman | — | Chicago Cubs | Chicago Cubs signed free agent RHP Marcus Stroman. |
| Dec 1, 2021 | Signed as free agent | Taylor Clarke | — | Kansas City Royals | Kansas City Royals signed free agent RHP Taylor Clarke. |
| Dec 1, 2021 | Signed as free agent | Rich Hill | — | Boston Red Sox | Boston Red Sox signed free agent LHP Rich Hill. |
| Dec 1, 2021 | Signed as free agent | James Paxton | — | Boston Red Sox | Boston Red Sox signed free agent LHP James Paxton. |
| Dec 1, 2021 | Signed as free agent | Trey Amburgey | — | Cincinnati Reds | Cincinnati Reds signed free agent LF Trey Amburgey to a minor league contract and invited him to spring training. |
| Dec 1, 2021 | Signed as free agent | Brandon Bailey | — | Cincinnati Reds | Cincinnati Reds signed free agent RHP Brandon Bailey to a minor league contract and invited him to spring training. |
| Dec 1, 2021 | Signed as free agent | Allen Córdoba | — | Cincinnati Reds | Cincinnati Reds signed free agent LF Allen Cordoba to a minor league contract and invited him to spring training. |
| Dec 1, 2021 | Signed as free agent | Andrew Knapp | — | Cincinnati Reds | Cincinnati Reds signed free agent C Andrew Knapp to a minor league contract and invited him to spring training. |
| Dec 1, 2021 | Signed as free agent | Trey Wingenter | — | Cincinnati Reds | Cincinnati Reds signed free agent RHP Trey Wingenter to a minor league contract and invited him to spring training. |
| Dec 1, 2021 | Signed as free agent | Jharel Cotton | — | Minnesota Twins | Minnesota Twins signed free agent RHP Jharel Cotton. |
| Dec 1, 2021 | Trade | Hunter Renfroe | Boston Red Sox | Milwaukee Brewers | Milwaukee Brewers traded CF Jackie Bradley Jr., SS David Hamilton and 3B Alex Binelas to Boston Red Sox for RF Hunter Renfroe. |
| Dec 1, 2021 | Signed as free agent | Michael Feliz | — | Boston Red Sox | Boston Red Sox signed free agent RHP Michael Feliz to a minor league contract. |
| Dec 1, 2021 | Signed as free agent | Danny Coulombe | — | Minnesota Twins | Minnesota Twins signed free agent LHP Danny Coulombe to a minor league contract. |
| Dec 1, 2021 | Signed as free agent | Jacob Nottingham | — | Baltimore Orioles | Baltimore Orioles signed free agent C Jacob Nottingham to a minor league contract. |
| Dec 1, 2021 | Signed as free agent | Christin Stewart | — | Boston Red Sox | Boston Red Sox signed free agent LF Christin Stewart to a minor league contract. |
| Dec 1, 2021 | Signed as free agent | Matt Reynolds | — | New York Mets | New York Mets signed free agent SS Matt Reynolds to a minor league contract. |
| Dec 1, 2021 | Signed as free agent | Cam Bedrosian | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RHP Cam Bedrosian to a minor league contract and invited him to spring training. |
| Dec 1, 2021 | Signed as free agent | Kyle Dohy | — | Philadelphia Phillies | Philadelphia Phillies signed free agent LHP Kyle Dohy to a minor league contract and invited him to spring training. |
| Dec 1, 2021 | Signed as free agent | Jake Faria | — | Minnesota Twins | Minnesota Twins signed free agent RHP Jake Faria to a minor league contract. |
| Dec 1, 2021 | Signed as free agent | Trevor Megill | — | Minnesota Twins | Minnesota Twins signed free agent RHP Trevor Megill to a minor league contract. |
| Dec 1, 2021 | Signed as free agent | Sam Delaplane | — | San Francisco Giants | San Francisco Giants signed free agent RHP Sam Delaplane to a minor league contract and invited him to spring training. |
| Dec 1, 2021 | Signed as free agent | Corey Oswalt | — | San Francisco Giants | San Francisco Giants signed free agent RHP Corey Oswalt to a minor league contract and invited him to spring training. |
| Dec 1, 2021 | Signed as free agent | Joe Palumbo | — | San Francisco Giants | San Francisco Giants signed free agent LHP Joe Palumbo to a minor league contract and invited him to spring training. |
| Dec 1, 2021 | Signed as free agent | Arquímedes Gamboa | — | San Francisco Giants | San Francisco Giants signed free agent SS Arquimedes Gamboa to a minor league contract and invited him to spring training. |
| Dec 1, 2021 | Signed as free agent | Luis González | — | San Francisco Giants | San Francisco Giants signed free agent OF Luis Gonzalez to a minor league contract and invited him to spring training. |
| Dec 1, 2021 | Signed as free agent | Keynan Middleton | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Keynan Middleton. |
| Dec 1, 2021 | Signed as free agent | Stephen Nogosek | — | New York Mets | New York Mets signed free agent RHP Stephen Nogosek to a minor league contract. |
| Dec 1, 2021 | Signed as free agent | Diego Dugarte | — | Chicago Cubs | Chicago Cubs signed free agent RHP Diego Dugarte to a minor league contract. |
| Nov 30, 2021 | Signed as free agent | Brett Sullivan | — | Milwaukee Brewers | Milwaukee Brewers signed free agent C Brett Sullivan. |
| Nov 30, 2021 | Signed as free agent | Kendall Graveman | — | Chicago White Sox | Chicago White Sox signed free agent RHP Kendall Graveman. |
| Nov 30, 2021 | Signed as free agent | Brooks Raley | — | Tampa Bay Rays | Tampa Bay Rays signed free agent LHP Brooks Raley. |
| Nov 30, 2021 | Signed as free agent | Kole Calhoun | — | Texas Rangers | Texas Rangers signed free agent RF Kole Calhoun. |
| Nov 30, 2021 | Trade | Kameron Misner | Miami Marlins | Tampa Bay Rays | Tampa Bay Rays traded 2B Joey Wendle to Miami Marlins for CF Kameron Misner. |
| Nov 30, 2021 | Released | Breyvic Valera | — | Toronto Blue Jays | Toronto Blue Jays released 2B Breyvic Valera. |
| Nov 30, 2021 | Signed as free agent | Rougned Odor | — | Baltimore Orioles | Baltimore Orioles signed free agent 2B Rougned Odor. |
| Nov 30, 2021 | Signed as free agent | Mark Canha | — | New York Mets | New York Mets signed free agent LF Mark Canha. |
| Nov 30, 2021 | Signed as free agent | César Hernández | — | Washington Nationals | Washington Nationals signed free agent 2B Cesar Hernandez. |
| Nov 30, 2021 | Signed as free agent | Starling Marte | — | New York Mets | New York Mets signed free agent LF Starling Marte. |
| Nov 30, 2021 | Signed as free agent | Michael Lorenzen | — | Los Angeles Angels | Los Angeles Angels signed free agent RHP Michael Lorenzen. |
| Nov 30, 2021 | Signed as free agent | Alex Cobb | — | San Francisco Giants | San Francisco Giants signed free agent RHP Alex Cobb. |
| Nov 30, 2021 | Signed as free agent | Robbie Ray | — | Seattle Mariners | Seattle Mariners signed free agent LHP Robbie Ray. |
| Nov 30, 2021 | Signed as free agent | Curtis Terry | — | Minnesota Twins | Minnesota Twins signed free agent 1B Curtis Terry to a minor league contract. |
| Nov 30, 2021 | Signed as free agent | Jair Jimenez | — | Chicago Cubs | Chicago Cubs signed free agent RHP Jair Jimenez to a minor league contract. |
| Nov 30, 2021 | Signed as free agent | Cristian Santana | — | Cincinnati Reds | Cincinnati Reds signed free agent 3B Cristian Santana to a minor league contract. |
| Nov 30, 2021 | Signed as free agent | Breiling Eusebio | — | Colorado Rockies | Colorado Rockies signed free agent LHP Breiling Eusebio to a minor league contract. |
| Nov 30, 2021 | Signed as free agent | Kyle Barraclough | — | Los Angeles Angels | Los Angeles Angels signed free agent RHP Kyle Barraclough to a minor league contract. |
| Nov 30, 2021 | Signed as free agent | Alex Blandino | — | San Francisco Giants | San Francisco Giants signed free agent 2B Alex Blandino to a minor league contract and invited him to spring training. |
| Nov 30, 2021 | Signed as free agent | Kyle Crick | — | Chicago White Sox | Chicago White Sox signed free agent RHP Kyle Crick and to a minor league contract and invited him to spring training. |
| Nov 29, 2021 | Signed as free agent | Aramis Garcia | — | Cincinnati Reds | Cincinnati Reds signed free agent C Aramis Garcia to a minor league contract and invited him to spring training. |
| Nov 29, 2021 | Signed as free agent | Matt Gage | — | Toronto Blue Jays | Toronto Blue Jays signed free agent LHP Matt Gage to a minor league contract and invited him to spring training. |
| Nov 29, 2021 | Signed as free agent | Casey Lawrence | — | Toronto Blue Jays | Toronto Blue Jays signed free agent RHP Casey Lawrence to a minor league contract and invited him to spring training. |
| Nov 29, 2021 | Signed as free agent | Nathan Lukes | — | Toronto Blue Jays | Toronto Blue Jays signed free agent CF Nathan Lukes to a minor league contract and invited him to spring training. |
| Nov 29, 2021 | Signed as free agent | David Phelps | — | Toronto Blue Jays | Toronto Blue Jays signed free agent RHP David Phelps to a minor league contract and invited him to spring training. |
| Nov 29, 2021 | Signed as free agent | Mallex Smith | — | Toronto Blue Jays | Toronto Blue Jays signed free agent CF Mallex Smith to a minor league contract and invited him to spring training. |
| Nov 29, 2021 | Signed as free agent | José De León | — | Toronto Blue Jays | Toronto Blue Jays signed free agent RHP Jose De Leon to a minor league contract and invited him to spring training. |
| Nov 29, 2021 | Signed as free agent | Jose Quintana | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent LHP Jose Quintana. |
| Nov 29, 2021 | Signed as free agent | Steven Matz | — | St. Louis Cardinals | St. Louis Cardinals signed free agent LHP Steven Matz. |
| Nov 29, 2021 | Signed as free agent | Yoshi Tsutsugo | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent LF Yoshi Tsutsugo. |
| Nov 29, 2021 | Trade | Connor Scott | Miami Marlins | Pittsburgh Pirates | Pittsburgh Pirates traded C Jacob Stallings to Miami Marlins for RHP Zach Thompson, RHP Kyle Nicolas and OF Connor Scott. |
| Nov 29, 2021 | Signed as free agent | Kirby Yates | — | Atlanta Braves | Atlanta Braves signed free agent RHP Kirby Yates. |
| Nov 29, 2021 | Released | Brooks Kriske | — | Baltimore Orioles | Baltimore Orioles released RHP Brooks Kriske. |
| Nov 29, 2021 | Released | Chris Gittens | — | New York Yankees | New York Yankees released 1B Chris Gittens. |
| Nov 29, 2021 | Signed as free agent | Pedro Severino | — | Milwaukee Brewers | Milwaukee Brewers signed free agent C Pedro Severino. |
| Nov 29, 2021 | Released | Cody Ponce | — | Pittsburgh Pirates | Pittsburgh Pirates released RHP Cody Ponce. |
| Nov 29, 2021 | Signed as free agent | Ryan Casteel | — | Atlanta Braves | Atlanta Braves signed free agent C Ryan Casteel to a minor league contract. |
| Nov 29, 2021 | Signed as free agent | Darren O'Day | — | Atlanta Braves | Atlanta Braves signed free agent RHP Darren O'Day to a minor league contract. |
| Nov 29, 2021 | Signed as free agent | Denyi Reyes | — | Baltimore Orioles | Baltimore Orioles signed free agent RHP Denyi Reyes to a minor league contract. |
| Nov 29, 2021 | Signed as free agent | Rex Brothers | — | Milwaukee Brewers | Milwaukee Brewers signed free agent LHP Rex Brothers to a minor league contract. |
| Nov 29, 2021 | Signed as free agent | Nick Dini | — | New York Mets | New York Mets signed free agent C Nick Dini to a minor league contract. |
| Nov 29, 2021 | Signed as free agent | Rob Zastryzny | — | New York Mets | New York Mets signed free agent LHP Rob Zastryzny to a minor league contract. |
| Nov 29, 2021 | Signed as free agent | Wandy Abreu | — | Boston Red Sox | Boston Red Sox signed free agent RHP Wandy Abreu to a minor league contract. |
| Nov 29, 2021 | Signed as free agent | Eddy Alvarez | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent SS Eddy Alvarez to a minor league contract and invited him to spring training. |
| Nov 29, 2021 | Signed as free agent | Braden Bishop | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent CF Braden Bishop to a minor league contract and invited him to spring training. |
| Nov 29, 2021 | Signed as free agent | Roberto Baldoquin | — | St. Louis Cardinals | St. Louis Cardinals signed free agent SS Roberto Baldoquin to a minor league contract. |
| Nov 28, 2021 | Signed as free agent | Rob Griswold | — | Atlanta Braves | Atlanta Braves signed free agent RHP Rob Griswold to a minor league contract. |
| Nov 28, 2021 | Signed as free agent | Narciso Crook | — | Chicago Cubs | Chicago Cubs signed free agent CF Narciso Crook to a minor league contract. |
| Nov 28, 2021 | Signed as free agent | Locke St. John | — | Chicago Cubs | Chicago Cubs signed free agent LHP Locke St. John to a minor league contract. |
| Nov 28, 2021 | Signed as free agent | Cam Hill | — | Chicago White Sox | Chicago White Sox signed free agent RHP Cam Hill to a minor league contract. |
| Nov 28, 2021 | Signed as free agent | Emilio Vargas | — | Chicago White Sox | Chicago White Sox signed free agent RHP Emilio Vargas to a minor league contract. |
| Nov 28, 2021 | Signed as free agent | Beau Burrows | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Beau Burrows to a minor league contract. |
| Nov 28, 2021 | Signed as free agent | Trey Cabbage | — | Los Angeles Angels | Los Angeles Angels signed free agent 3B Trey Cabbage to a minor league contract. |
| Nov 28, 2021 | Signed as free agent | Zack Weiss | — | Los Angeles Angels | Los Angeles Angels signed free agent RHP Zack Weiss to a minor league contract. |
| Nov 28, 2021 | Signed as free agent | Ray-Patrick Didder | — | Miami Marlins | Miami Marlins signed free agent CF Ray-Patrick Didder to a minor league contract. |
| Nov 28, 2021 | Signed as free agent | Jason Alexander | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Jason Alexander to a minor league contract. |
| Nov 28, 2021 | Signed as free agent | Trevor Kelley | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Trevor Kelley to a minor league contract. |
| Nov 28, 2021 | Signed as free agent | Nate Fisher | — | New York Mets | New York Mets signed free agent LHP Nate Fisher to a minor league contract. |
| Nov 28, 2021 | Signed as free agent | José Peraza | — | New York Yankees | New York Yankees signed free agent SS Jose Peraza to a minor league contract. |
| Nov 28, 2021 | Signed as free agent | Michael Kelly | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RHP Michael Kelly to a minor league contract. |
| Nov 28, 2021 | Signed as free agent | Jerad Eickhoff | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent RHP Jerad Eickhoff to a minor league contract. |
| Nov 28, 2021 | Signed as free agent | Jamie Ritchie | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent C Jamie Ritchie to a minor league contract. |
| Nov 28, 2021 | Signed as free agent | Trevor Hildenberger | — | San Francisco Giants | San Francisco Giants signed free agent RHP Trevor Hildenberger to a minor league contract. |
| Nov 28, 2021 | Signed as free agent | Richard Urena | — | Washington Nationals | Washington Nationals signed free agent SS Richard Urena to a minor league contract. |
| Nov 28, 2021 | Signed as free agent | Erik González | — | Miami Marlins | Miami Marlins signed free agent 2B Erik Gonzalez to a minor league contract. |
| Nov 27, 2021 | Signed as free agent | Michael Wacha | — | Boston Red Sox | Boston Red Sox signed free agent RHP Michael Wacha. |
| Nov 27, 2021 | Trade | Adam Frazier | San Diego Padres | Seattle Mariners | San Diego Padres traded 2B Adam Frazier to Seattle Mariners for LHP Ray Kerr and OF Corey Rosier. |
| Nov 26, 2021 | Trade | Jordan Luplow | Tampa Bay Rays | Arizona Diamondbacks | Tampa Bay Rays traded LF Jordan Luplow to Arizona Diamondbacks for SS Ronny Simon. |
| Nov 26, 2021 | Signed as free agent | Max George | — | Colorado Rockies | Colorado Rockies signed free agent SS Max George to a minor league contract. |
| Nov 26, 2021 | Signed as free agent | Gemil Santa | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Gemil Santa to a minor league contract. |
| Nov 25, 2021 | Signed as free agent | Christian Bethancourt | — | Athletics | Oakland Athletics signed free agent C Christian Bethancourt to a minor league contract. |
| Nov 25, 2021 | Signed as free agent | Luis Avilán | — | Washington Nationals | Washington Nationals signed free agent LHP Luis Avilan to a minor league contract. |
| Nov 24, 2021 | Signed as free agent | Nick Plummer | — | New York Mets | New York Mets signed free agent CF Nick Plummer. |
| Nov 24, 2021 | Signed as free agent | Chen Zhong-Ao Zhuang | — | Athletics | Oakland Athletics signed free agent RHP Chen Zhong-Ao Zhuang to a minor league contract. |
| Nov 24, 2021 | Signed as free agent | Víctor Arano | — | Washington Nationals | Washington Nationals signed free agent RHP Victor Arano to a minor league contract. |
| Nov 24, 2021 | Released | Kyle Zimmer | — | Kansas City Royals | Kansas City Royals released RHP Kyle Zimmer. |
| Nov 24, 2021 | Released | Kean Wong | — | Los Angeles Angels | Los Angeles Angels released 2B Kean Wong. |
| Nov 24, 2021 | Released | Alex Dickerson | — | San Francisco Giants | San Francisco Giants released LF Alex Dickerson. |
| Nov 24, 2021 | Signed as free agent | Jeison Guzmán | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent SS Jeison Guzman to a minor league contract. |
| Nov 24, 2021 | Signed as free agent | Ben Norman | — | Chicago White Sox | Chicago White Sox signed free agent OF Ben Norman to a minor league contract. |
| Nov 24, 2021 | Signed as free agent | Markus Solbach | — | Detroit Tigers | Detroit Tigers signed free agent RHP Markus Solbach to a minor league contract. |
| Nov 24, 2021 | Signed as free agent | Brian Moran | — | Los Angeles Angels | Los Angeles Angels signed free agent LHP Brian Moran to a minor league contract. |
| Nov 24, 2021 | Signed as free agent | Angel Roman | — | Washington Nationals | Washington Nationals signed free agent LHP Angel Roman to a minor league contract. |
| Nov 23, 2021 | Released | Willians Astudillo | — | Minnesota Twins | Minnesota Twins released C Willians Astudillo. |
| Nov 23, 2021 | Released | Clint Frazier | — | New York Yankees | New York Yankees released LF Clint Frazier. |
| Nov 23, 2021 | Released | Rougned Odor | — | New York Yankees | New York Yankees released 2B Rougned Odor. |
| Nov 23, 2021 | Signed as free agent | Jose Montero | — | Cincinnati Reds | Cincinnati Reds signed free agent RHP Jose Montero to a minor league contract. |
| Nov 22, 2021 | Trade | J.C. Mejía | Cleveland Guardians | Milwaukee Brewers | Cleveland Guardians traded RHP J.C. Mejia to Milwaukee Brewers for Player To Be Named Later. |
| Nov 22, 2021 | Trade | Tyler Wade | New York Yankees | Los Angeles Angels | New York Yankees traded 2B Tyler Wade to Los Angeles Angels for Player To Be Named Later. |
| Nov 22, 2021 | Trade | Harold Ramírez | Cleveland Guardians | Chicago Cubs | Cleveland Guardians traded RF Harold Ramirez to Chicago Cubs for cash. |
| Nov 22, 2021 | Signed as free agent | Sandy León | — | Cleveland Guardians | Cleveland Guardians signed free agent C Sandy Leon. |
| Nov 22, 2021 | Trade | Jay Jackson | San Francisco Giants | Atlanta Braves | San Francisco Giants traded RHP Jay Jackson to Atlanta Braves for Player To Be Named Later. |
| Nov 22, 2021 | Trade | Billy McKinney | Los Angeles Dodgers | Texas Rangers | Los Angeles Dodgers traded LF Billy McKinney and OF Zach Reks to Texas Rangers for cash. |
| Nov 22, 2021 | Signed as free agent | Aaron Loup | — | Los Angeles Angels | Los Angeles Angels signed free agent LHP Aaron Loup. |
| Nov 22, 2021 | Signed as free agent | Unnamed | — | San Francisco Giants | San Francisco Giants signed free agent RHP Anthony DeSclafani, and. |
| Nov 22, 2021 | Signed as free agent | Leandro Cedeño | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent 1B Leandro Cedeno to a minor league contract. |
| Nov 22, 2021 | Signed as free agent | Michael Petersen | — | Colorado Rockies | Colorado Rockies signed free agent RHP Michael Petersen to a minor league contract. |
| Nov 22, 2021 | Signed as free agent | Argenis Angulo | — | Minnesota Twins | Minnesota Twins signed free agent RHP Argenis Angulo to a minor league contract. |
| Nov 20, 2021 | Signed as free agent | Ramon Sanchez | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP Ramon Sanchez to a minor league contract. |
| Nov 20, 2021 | Signed as free agent | Michael Saturria | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP Michael Saturria to a minor league contract. |
| Nov 19, 2021 | Trade | Donny Sands | New York Yankees | Philadelphia Phillies | New York Yankees traded RHP Nick Nelson and C Donny Sands to Philadelphia Phillies for 3B T.J. Rumfield and LHP Joel Valdez. |
| Nov 19, 2021 | Trade | Unnamed | Athletics | Tampa Bay Rays | Tampa Bay Rays traded RHP Brent Honeywell Jr. to Oakland Athletics for cash. |
| Nov 19, 2021 | Trade | Tobias Myers | Tampa Bay Rays | Cleveland Guardians | Tampa Bay Rays traded RHP Tobias Myers to Cleveland Indians for SS Junior Caminero. |
| Nov 19, 2021 | Trade | Garrett Stubbs | Houston Astros | Philadelphia Phillies | Houston Astros traded C Garrett Stubbs to Philadelphia Phillies for OF Logan Cerny. |
| Nov 19, 2021 | Released | Junior Guerra | — | Los Angeles Angels | Los Angeles Angels released RHP Junior Guerra. |
| Nov 19, 2021 | Signed as free agent | Brayan Romero | — | Washington Nationals | Washington Nationals signed free agent RHP Brayan Romero to a minor league contract. |
| Nov 19, 2021 | Signed as free agent | Marcos Diplán | — | Baltimore Orioles | Baltimore Orioles signed free agent RHP Marcos Diplan to a minor league contract. |
| Nov 19, 2021 | Signed as free agent | P.J. Higgins | — | Chicago Cubs | Chicago Cubs signed free agent C P.J. Higgins to a minor league contract. |
| Nov 19, 2021 | Signed as free agent | Jonathan Holder | — | Chicago Cubs | Chicago Cubs signed free agent RHP Jonathan Holder to a minor league contract. |
| Nov 19, 2021 | Signed as free agent | Andrew Bellatti | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RHP Andrew Bellatti to a minor league contract. |
| Nov 19, 2021 | Signed as free agent | Josh Lester | — | Detroit Tigers | Detroit Tigers signed free agent 3B Josh Lester to a minor league contract. |
| Nov 19, 2021 | Signed as free agent | Jason Martin | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent CF Jason Martin to a minor league contract and invited him to spring training. |
| Nov 19, 2021 | Signed as free agent | C.J. Chatham | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent SS C.J. Chatham to a minor league contract and invited him to spring training. |
| Nov 19, 2021 | Signed as free agent | Jimmy Yacabonis | — | Miami Marlins | Miami Marlins signed free agent RHP Jimmy Yacabonis to a minor league contract and invited him to spring training. |
| Nov 19, 2021 | Signed as free agent | Emmanuel Ramirez | — | New York Yankees | New York Yankees signed free agent RHP Emmanuel Ramirez and to a minor league contract. |
| Nov 19, 2021 | Trade | TJ Rumfield | Philadelphia Phillies | New York Yankees | Philadelphia Phillies traded 3B T.J. Rumfield to New York Yankees. |
| Nov 19, 2021 | Trade | Joel Valdez | Philadelphia Phillies | New York Yankees | Philadelphia Phillies traded LHP Joel Valdez to New York Yankees. |
| Nov 19, 2021 | Signed as free agent | Andy Colon | — | Houston Astros | Houston Astros signed free agent OF Andy Colon to a minor league contract. |
| Nov 18, 2021 | Signed as free agent | Jose Liriano | — | Boston Red Sox | Boston Red Sox signed free agent OF Jose Liriano to a minor league contract. |
| Nov 18, 2021 | Signed as free agent | Jonathan Davis | — | Milwaukee Brewers | Milwaukee Brewers signed free agent CF Jonathan Davis to a minor league contract. |
| Nov 18, 2021 | Signed as free agent | Connor Overton | — | Cincinnati Reds | Cincinnati Reds signed free agent RHP Connor Overton and to a minor league contract and invited him to spring training. |
| Nov 18, 2021 | Signed as free agent | Peter Tago | — | San Francisco Giants | San Francisco Giants signed free agent RHP Peter Tago to a minor league contract and invited him to spring training. |
| Nov 17, 2021 | Signed as free agent | Brandon Belt | — | San Francisco Giants | San Francisco Giants signed free agent 1B Brandon Belt. |
| Nov 17, 2021 | Released | Dietrich Enns | — | Tampa Bay Rays | Tampa Bay Rays released LHP Dietrich Enns. |
| Nov 17, 2021 | Signed as free agent | Aneurys Zabala | — | Miami Marlins | Miami Marlins signed free agent RHP Aneurys Zabala to a minor league contract. |
| Nov 17, 2021 | Signed as free agent | Michael Gettys | — | Boston Red Sox | Boston Red Sox signed free agent CF Michael Gettys to a minor league contract. |
| Nov 16, 2021 | Signed as free agent | Eduardo Rodriguez | — | Detroit Tigers | Detroit Tigers signed free agent LHP Eduardo Rodriguez. |
| Nov 16, 2021 | Signed as free agent | Jake Gatewood | — | Los Angeles Angels | Los Angeles Angels signed free agent SS Jake Gatewood to a minor league contract. |
| Nov 16, 2021 | Released | Taylor Davis | — | Pittsburgh Pirates | Pittsburgh Pirates released 3B Taylor Davis. |
| Nov 16, 2021 | Signed as free agent | Noah Syndergaard | — | Los Angeles Angels | Los Angeles Angels signed free agent RHP Noah Syndergaard. |
| Nov 16, 2021 | Signed as free agent | Cristian Bastardo | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP Cristian Bastardo to a minor league contract. |
| Nov 16, 2021 | Signed as free agent | Keiner Navas | — | Tampa Bay Rays | Tampa Bay Rays signed free agent LHP Keiner Navas to a minor league contract. |
| Nov 16, 2021 | Signed as free agent | Jerffson Pena | — | Philadelphia Phillies | Philadelphia Phillies signed free agent OF Jerffson Pena to a minor league contract. |
| Nov 16, 2021 | Signed as free agent | Adilson Peralta | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RHP Adilson Peralta to a minor league contract. |
| Nov 16, 2021 | Signed as free agent | Luis Alexander Basabe | — | Chicago White Sox | Chicago White Sox signed free agent CF Luis Alexander Basabe and to a minor league contract and invited him to spring training. |
| Nov 16, 2021 | Signed as free agent | Alberto Guerrero | — | Washington Nationals | Washington Nationals signed free agent RHP Alberto Guerrero and to a minor league contract. |
| Nov 15, 2021 | Signed as free agent | Manny Piña | — | Atlanta Braves | Atlanta Braves signed free agent C Manny Pina. |
| Nov 15, 2021 | Signed as free agent | Trey Supak | — | Athletics | Oakland Athletics signed free agent RHP Trey Supak to a minor league contract. |
| Nov 15, 2021 | Signed as free agent | Jordan Brink | — | San Diego Padres | San Diego Padres signed free agent RHP Jordan Brink to a minor league contract. |
| Nov 15, 2021 | Signed as free agent | Heath Fillmyer | — | San Diego Padres | San Diego Padres signed free agent RHP Heath Fillmyer to a minor league contract. |
| Nov 15, 2021 | Signed as free agent | Steven Fuentes | — | Washington Nationals | Washington Nationals signed free agent RHP Steven Fuentes to a minor league contract. |
| Nov 14, 2021 | Trade | Louis Head | Tampa Bay Rays | Miami Marlins | Tampa Bay Rays traded RHP Louis Head to Miami Marlins for Player To Be Named Later. |
| Nov 13, 2021 | Signed as free agent | Unnamed | — | Colorado Rockies | Colorado Rockies signed free agent RHP Jhoulys Chacin, and. |
| Nov 13, 2021 | Trade | Mike Brosseau | Tampa Bay Rays | Milwaukee Brewers | Milwaukee Brewers traded RHP Evan Reifert to Tampa Bay Rays for 3B Mike Brosseau. |
| Nov 13, 2021 | Signed as free agent | Juan Graterol | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent C Juan Graterol to a minor league contract. |
| Nov 13, 2021 | Signed as free agent | Jose Gomez | — | New York Mets | New York Mets signed free agent RHP Jose Gomez to a minor league contract. |
| Nov 12, 2021 | Signed as free agent | Jensi Ramirez | — | Chicago Cubs | Chicago Cubs signed free agent RHP Jensi Ramirez to a minor league contract. |
| Nov 12, 2021 | Signed as free agent | Eligio Paredes | — | Chicago Cubs | Chicago Cubs signed free agent RHP Eligio Paredes to a minor league contract. |
| Nov 12, 2021 | Signed as free agent | Kevin Valdez | — | Chicago Cubs | Chicago Cubs signed free agent LHP Kevin Valdez to a minor league contract. |
| Nov 12, 2021 | Signed as free agent | Yafrerlyn Vasquez | — | Chicago Cubs | Chicago Cubs signed free agent RHP Yafrerlyn Vasquez to a minor league contract. |
| Nov 12, 2021 | Signed as free agent | Rico Garcia | — | Baltimore Orioles | Baltimore Orioles signed free agent RHP Rico Garcia to a minor league contract. |
| Nov 12, 2021 | Signed as free agent | Cristian Nunez | — | Boston Red Sox | Boston Red Sox signed free agent RHP Cristian Nunez to a minor league contract. |
| Nov 12, 2021 | Signed as free agent | Jagger Rusconi | — | Chicago White Sox | Chicago White Sox signed free agent 2B Jagger Rusconi to a minor league contract. |
| Nov 12, 2021 | Signed as free agent | Hobie Harris | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Hobie Harris to a minor league contract. |
| Nov 12, 2021 | Signed as free agent | Spenser Watkins | — | Baltimore Orioles | Baltimore Orioles signed free agent RHP Spenser Watkins to a minor league contract. |
| Nov 11, 2021 | Signed as free agent | Melvin Pineda | — | San Francisco Giants | San Francisco Giants signed free agent RHP Melvin Pineda to a minor league contract. |
| Nov 11, 2021 | Signed as free agent | Logan Cozart | — | Colorado Rockies | Colorado Rockies signed free agent RHP Logan Cozart to a minor league contract. |
| Nov 11, 2021 | Signed as free agent | Andruw Monasterio | — | Milwaukee Brewers | Milwaukee Brewers signed free agent SS Andruw Monasterio to a minor league contract. |
| Nov 11, 2021 | Signed as free agent | David Hess | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP David Hess to a minor league contract. |
| Nov 10, 2021 | Signed as free agent | Andrew Heaney | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent LHP Andrew Heaney. |
| Nov 10, 2021 | Signed as free agent | Joely Rodríguez | — | New York Yankees | New York Yankees signed free agent LHP Joely Rodriguez. |
| Nov 10, 2021 | Released | Adam Conley | — | Tampa Bay Rays | Tampa Bay Rays released LHP Adam Conley. |
| Nov 10, 2021 | Signed as free agent | Sean McLaughlin | — | Los Angeles Angels | Los Angeles Angels signed free agent RHP Sean McLaughlin to a minor league contract. |
| Nov 10, 2021 | Signed as free agent | Adrián Sanchez | — | Washington Nationals | Washington Nationals signed free agent 3B Adrian Sanchez to a minor league contract. |
| Nov 9, 2021 | Signed as free agent | Pedro Marquez | — | Houston Astros | Houston Astros signed free agent RHP Pedro Marquez to a minor league contract. |
| Nov 9, 2021 | Signed as free agent | Bubby Rossman | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RHP Bubby Rossman to a minor league contract. |
| Nov 9, 2021 | Signed as free agent | Anderson Tejeda | — | St. Louis Cardinals | St. Louis Cardinals signed free agent SS Anderson Tejeda to a minor league contract. |
| Nov 8, 2021 | Signed as free agent | Unnamed | — | St. Louis Cardinals | St. Louis Cardinals signed free agent LHP T.J. McFarland, and. |
| Nov 8, 2021 | Signed as free agent | Jon Olczak | — | Houston Astros | Houston Astros signed free agent RHP Jon Olczak to a minor league contract. |
| Nov 8, 2021 | Signed as free agent | Nathan Kirby | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent LHP Nathan Kirby to a minor league contract. |
| Nov 8, 2021 | Signed as free agent | Jefry Rodriguez | — | Washington Nationals | Washington Nationals signed free agent RHP Jefry Rodriguez to a minor league contract. |
| Nov 8, 2021 | Signed as free agent | Luis Reyes | — | Washington Nationals | Washington Nationals signed free agent RHP Luis Reyes to a minor league contract. |
| Nov 7, 2021 | Released | Grant Dayton | — | Atlanta Braves | Atlanta Braves released LHP Grant Dayton. |
| Nov 7, 2021 | Signed as free agent | Oscar Gonzalez | — | Cleveland Guardians | Cleveland Indians signed free agent RF Oscar Gonzalez to a minor league contract. |
| Nov 7, 2021 | Signed as free agent | Nolan Riggs | — | Houston Astros | Houston Astros signed free agent RHP Nolan Riggs to a minor league contract. |
| Nov 6, 2021 | Signed as free agent | Tyler Phillips | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RHP Tyler Phillips to a minor league contract. |
| Nov 5, 2021 | Signed as free agent | Chalniel Arias | — | New York Yankees | New York Yankees signed free agent RHP Chalniel Arias to a minor league contract. |
| Nov 5, 2021 | Signed as free agent | Alexis Paulino | — | New York Yankees | New York Yankees signed free agent RHP Alexis Paulino to a minor league contract. |
| Nov 5, 2021 | Signed as free agent | David Beckles | — | New York Yankees | New York Yankees signed free agent LF David Beckles to a minor league contract. |
| Nov 5, 2021 | Signed as free agent | Moisés Gómez | — | St. Louis Cardinals | St. Louis Cardinals signed free agent CF Moises Gomez to a minor league contract. |
| Nov 3, 2021 | Trade | Tucker Barnhart | Cincinnati Reds | Detroit Tigers | Cincinnati Reds traded C Tucker Barnhart, and to Detroit Tigers for 3B Nick Quintana. |
| Nov 3, 2021 | Signed as free agent | Trevor Gott | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Trevor Gott. |
| Nov 3, 2021 | Signed as free agent | Biembenido Brito | — | Texas Rangers | Texas Rangers signed free agent RHP Biembenido Brito to a minor league contract. |
| Nov 3, 2021 | Signed as free agent | Carlos Montes | — | Houston Astros | Houston Astros signed free agent RHP Carlos Montes to a minor league contract. |
| Nov 3, 2021 | Signed as free agent | Sandro Gaston | — | Houston Astros | Houston Astros signed free agent C Sandro Gaston to a minor league contract. |
| Nov 3, 2021 | Signed as free agent | Wilton Lara | — | Houston Astros | Houston Astros signed free agent 3B Wilton Lara to a minor league contract. |
| Nov 3, 2021 | Signed as free agent | Frank Moreno | — | Detroit Tigers | Detroit Tigers signed free agent RHP Frank Moreno to a minor league contract. |
| Nov 3, 2021 | Signed as free agent | Roger Jorge | — | Houston Astros | Houston Astros signed free agent OF Roger Jorge to a minor league contract. |
| Nov 2, 2021 | Signed as free agent | Sean Nolin | — | Washington Nationals | Washington Nationals signed free agent LHP Sean Nolin to a minor league contract. |
| Nov 1, 2021 | Released | Ryan McBroom | — | Kansas City Royals | Kansas City Royals released 1B Ryan McBroom. |
| Nov 1, 2021 | Signed as free agent | Wilfrido Bido | — | New York Yankees | New York Yankees signed free agent RHP Wilfrido Bido to a minor league contract. |
| Nov 1, 2021 | Signed as free agent | Johan Ferreira | — | New York Yankees | New York Yankees signed free agent 3B Johan Ferreira to a minor league contract. |
| Nov 1, 2021 | Signed as free agent | Andry Javier | — | New York Yankees | New York Yankees signed free agent SS Andry Javier to a minor league contract. |
| Nov 1, 2021 | Signed as free agent | Luis Ogando | — | New York Yankees | New York Yankees signed free agent SS Luis Ogando to a minor league contract. |
| Nov 1, 2021 | Signed as free agent | Edward Sanchez | — | New York Yankees | New York Yankees signed free agent SS Edward Sanchez to a minor league contract. |
| Nov 1, 2021 | Signed as free agent | Alsander Womack | — | Chicago White Sox | Chicago White Sox signed free agent 2B Alsander Womack to a minor league contract. |
| Oct 29, 2021 | Released | Drew Anderson | — | Texas Rangers | Texas Rangers released RHP Drew Anderson. |
| Oct 29, 2021 | Signed as free agent | Enzo Paulino | — | Tampa Bay Rays | Tampa Bay Rays signed free agent OF Enzo Paulino to a minor league contract. |
| Oct 29, 2021 | Signed as free agent | Gerlin Rosario | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP Gerlin Rosario to a minor league contract. |
| Oct 29, 2021 | Signed as free agent | Miguel Jorge | — | Texas Rangers | Texas Rangers signed free agent RHP Miguel Jorge to a minor league contract. |
| Oct 27, 2021 | Released | Edgar Santana | — | Atlanta Braves | Atlanta Braves released RHP Edgar Santana. |
| Oct 26, 2021 | Signed as free agent | Maxwel Hernandez | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RHP Maxwel Hernandez to a minor league contract. |
| Oct 25, 2021 | Signed as free agent | Chris Devenski | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Chris Devenski to a minor league contract. |
| Oct 22, 2021 | Signed as free agent | Andinson Ferrer | — | New York Mets | New York Mets signed free agent RHP Andinson Ferrer to a minor league contract. |
| Oct 22, 2021 | Signed as free agent | Welvis Colon | — | New York Mets | New York Mets signed free agent RHP Welvis Colon to a minor league contract. |
| Oct 21, 2021 | Signed as free agent | Josbel Garcia | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RHP Josbel Garcia to a minor league contract. |
| Oct 21, 2021 | Signed as free agent | Maikel Rosales | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RHP Maikel Rosales to a minor league contract. |
| Oct 21, 2021 | Signed as free agent | Luis Acevedo | — | Washington Nationals | Washington Nationals signed free agent LHP Luis Acevedo to a minor league contract. |
| Oct 20, 2021 | Trade | Zach Willeman | Los Angeles Dodgers | Kansas City Royals | Los Angeles Dodgers traded RHP Zach Willeman to Kansas City Royals. |
| Oct 20, 2021 | Signed as free agent | Alejandro Rivero | — | Chicago Cubs | Chicago Cubs signed free agent SS Alejandro Rivero to a minor league contract. |
| Oct 20, 2021 | Signed as free agent | Gregori Cano | — | Toronto Blue Jays | Toronto Blue Jays signed free agent IF Gregori Cano to a minor league contract. |
| Oct 18, 2021 | Signed as free agent | Leomar Rosario | — | Houston Astros | Houston Astros signed free agent RHP Leomar Rosario to a minor league contract. |
| Oct 16, 2021 | Signed as free agent | Dioni Baez | — | Kansas City Royals | Kansas City Royals signed free agent RHP Yohan Baez to a minor league contract. |
| Oct 16, 2021 | Signed as free agent | Dany Jiménez | — | Athletics | Oakland Athletics signed free agent RHP Dany Jimenez to a minor league contract. |
| Oct 15, 2021 | Signed as free agent | Alejandro Manzano | — | Athletics | Oakland Athletics signed free agent RHP Alejandro Manzano to a minor league contract. |
| Oct 15, 2021 | Signed as free agent | Wilkerson Hernandez | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Wilkerson Hernandez to a minor league contract. |
| Oct 15, 2021 | Signed as free agent | Luis Rodriguez | — | Houston Astros | Houston Astros signed free agent RHP Luis Rodriguez to a minor league contract. |
| Oct 15, 2021 | Signed as free agent | Abraham Almonte | — | Milwaukee Brewers | Milwaukee Brewers signed free agent CF Abraham Almonte to a minor league contract and invited him to spring training. |
| Oct 14, 2021 | Signed as free agent | Renaldito Florian | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP Renaldito Florian to a minor league contract. |
| Oct 14, 2021 | Signed as free agent | Sandy Eusebio | — | Tampa Bay Rays | Tampa Bay Rays signed free agent LHP Sandy Eusebio to a minor league contract. |
| Oct 12, 2021 | Signed as free agent | Victor Morin | — | Los Angeles Angels | Los Angeles Angels signed free agent RHP Victor Morin to a minor league contract. |
| Oct 10, 2021 | Signed as free agent | Juan Mateo | — | Atlanta Braves | Atlanta Braves signed free agent RHP Juan Mateo to a minor league contract. |
| Oct 8, 2021 | Signed as free agent | Junior Delanda | — | Boston Red Sox | Boston Red Sox signed free agent RHP Junior Delanda to a minor league contract. |
| Oct 8, 2021 | Signed as free agent | Smil Guzman | — | Boston Red Sox | Boston Red Sox signed free agent RHP Smil Guzman to a minor league contract. |
| Oct 8, 2021 | Signed as free agent | Guillermo Arvizu | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent LHP Guillermo Arvizu to a minor league contract. |
| Oct 5, 2021 | Released | Tanner Anderson | — | Pittsburgh Pirates | Pittsburgh Pirates released RHP Tanner Anderson. |
| Oct 5, 2021 | Released | Phillip Evans | — | Pittsburgh Pirates | Pittsburgh Pirates released 3B Phillip Evans. |
| Oct 4, 2021 | Signed as free agent | Ali Ascanio | — | Boston Red Sox | Boston Red Sox signed free agent RHP Ali Ascanio to a minor league contract. |
| Oct 4, 2021 | Signed as free agent | Luis A. Reyes | — | Chicago Cubs | Chicago Cubs signed free agent RHP Luis Reyes to a minor league contract. |
| Oct 4, 2021 | Signed as free agent | Edward Vargas | — | Chicago Cubs | Chicago Cubs signed free agent OF Edward Vargas to a minor league contract. |
| Oct 4, 2021 | Signed as free agent | Luis Barett | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent OF Luis Barett to a minor league contract. |
| Oct 4, 2021 | Signed as free agent | Tyler Johnson | — | Chicago White Sox | Chicago White Sox signed free agent RHP Tyler Johnson to a minor league contract. |
| Oct 4, 2021 | Signed as free agent | Vince Sanchez | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Vince Sanchez to a minor league contract. |
| Oct 2, 2021 | Signed as free agent | Claudio Scotti | — | New York Mets | New York Mets signed free agent RHP Claudio Scotti to a minor league contract. |
| Oct 1, 2021 | Released | Michael Feliz | — | Athletics | Oakland Athletics released RHP Michael Feliz. |
| Sep 30, 2021 | Signed as free agent | Fernando Estrella | — | San Francisco Giants | San Francisco Giants signed free agent RHP Fernando Estrella to a minor league contract. |
| Sep 30, 2021 | Signed as free agent | Andriel Lantigua | — | New York Mets | New York Mets signed free agent C Andriel Lantigua to a minor league contract. |
| Sep 30, 2021 | Signed as free agent | Melvin Javier | — | San Francisco Giants | San Francisco Giants signed free agent RHP Melvin Javier to a minor league contract. |
| Sep 30, 2021 | Signed as free agent | Angel Diaz | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent C Angel Diaz to a minor league contract. |
| Sep 29, 2021 | Released | Jake Lamb | — | Toronto Blue Jays | Toronto Blue Jays released 3B Jake Lamb. |
| Sep 28, 2021 | Signed as free agent | Alain Pena | — | Houston Astros | Houston Astros signed free agent RHP Alain Pena to a minor league contract. |
| Sep 26, 2021 | Released | Matt Joyce | — | Philadelphia Phillies | Philadelphia Phillies released RF Matt Joyce. |
| Sep 26, 2021 | Released | Shane Greene | — | Los Angeles Dodgers | Los Angeles Dodgers released RHP Shane Greene. |
| Sep 25, 2021 | Signed as free agent | Miguel Olivares | — | Minnesota Twins | Minnesota Twins signed free agent RHP Miguel Olivares to a minor league contract. |
| Sep 25, 2021 | Signed as free agent | Ka'ai Tom | — | San Francisco Giants | San Francisco Giants signed free agent LF Ka'ai Tom to a minor league contract. |
| Sep 24, 2021 | Signed as free agent | Jose Cabrera | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Jose Cabrera to a minor league contract. |
| Sep 24, 2021 | Signed as free agent | Daniel Castro | — | Houston Astros | Houston Astros signed free agent C Daniel Castro to a minor league contract. |
| Sep 23, 2021 | Signed as free agent | Jake Petricka | — | Los Angeles Angels | Los Angeles Angels signed free agent RHP Jake Petricka to a minor league contract. |
| Sep 23, 2021 | Signed as free agent | John Nogowski | — | San Francisco Giants | San Francisco Giants signed free agent 1B John Nogowski to a minor league contract. |
| Sep 22, 2021 | Released | Aramis Garcia | — | Athletics | Oakland Athletics released C Aramis Garcia. |
| Sep 22, 2021 | Released | Jake Arrieta | — | San Diego Padres | San Diego Padres released RHP Jake Arrieta. |
| Sep 21, 2021 | Released | Jake Petricka | — | Los Angeles Angels | Los Angeles Angels released RHP Jake Petricka. |
| Sep 21, 2021 | Released | Tyler Phillips | — | Philadelphia Phillies | Philadelphia Phillies released RHP Tyler Phillips. |
| Sep 21, 2021 | Signed as free agent | Alvaro Benua | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent Alvaro Benua to a minor league contract. |
| Sep 21, 2021 | Signed as free agent | Wyatt Hoffman | — | San Diego Padres | San Diego Padres signed free agent SS Wyatt Hoffman to a minor league contract. |
| Sep 20, 2021 | Released | Sal Romano | — | New York Yankees | New York Yankees released RHP Sal Romano. |
| Sep 16, 2021 | Released | Brad Brach | — | Cincinnati Reds | Cincinnati Reds released RHP Brad Brach. |
| Sep 16, 2021 | Signed as free agent | Hector Cuevas | — | Houston Astros | Houston Astros signed free agent RHP Hector Cuevas to a minor league contract. |
| Sep 16, 2021 | Signed as free agent | Normar Torres | — | Houston Astros | Houston Astros signed free agent RHP Normar Torres to a minor league contract. |
| Sep 15, 2021 | Signed as free agent | Vince Velasquez | — | San Diego Padres | San Diego Padres signed free agent RHP Vince Velasquez to a minor league contract. |
| Sep 15, 2021 | Signed as free agent | Adalfi Paredes | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP Adalfi Paredes to a minor league contract. |
| Sep 14, 2021 | Signed as free agent | Sal Romano | — | New York Yankees | New York Yankees signed free agent RHP Sal Romano. |
| Sep 14, 2021 | Signed as free agent | Ross Detwiler | — | San Diego Padres | San Diego Padres signed free agent LHP Ross Detwiler. |
| Sep 14, 2021 | Signed as free agent | Victor Diaz | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent C Victor Diaz to a minor league contract. |
| Sep 14, 2021 | Signed | Wilder Zapata | — | Cincinnati Reds | Cincinnati Reds signed RHP Wilder Zapata. |
| Sep 14, 2021 | Signed as free agent | Luis Pelegrin | — | Philadelphia Phillies | Philadelphia Phillies signed free agent SS Luis Pelegrin to a minor league contract. |
| Sep 12, 2021 | Released | Vince Velasquez | — | Philadelphia Phillies | Philadelphia Phillies released RHP Vince Velasquez. |
| Sep 11, 2021 | Released | Ross Detwiler | — | Miami Marlins | Miami Marlins released LHP Ross Detwiler. |
| Sep 10, 2021 | Signed as free agent | Yanquiel Sanchez | — | Houston Astros | Houston Astros signed free agent LHP Yanquiel Sanchez to a minor league contract. |
| Sep 10, 2021 | Signed as free agent | Jackson McClelland | — | Chicago Cubs | Chicago Cubs signed free agent RHP Jackson McClelland to a minor league contract. |
| Sep 10, 2021 | Signed as free agent | Andy Burns | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent 3B Andy Burns to a minor league contract. |
| Sep 8, 2021 | Released | Seth Frankoff | — | Arizona Diamondbacks | Arizona Diamondbacks released RHP Seth Frankoff. |
| Sep 8, 2021 | Signed | Jommer Hernandez | — | Toronto Blue Jays | Toronto Blue Jays signed C Jommer Hernandez. |
| Sep 7, 2021 | Signed as free agent | Kevin McCarthy | — | Chicago White Sox | Chicago White Sox signed free agent RHP Kevin McCarthy to a minor league contract. |
| Sep 7, 2021 | Signed as free agent | Javier Reina | — | Athletics | Oakland Athletics signed free agent RHP Javier Reina to a minor league contract. |
| Sep 7, 2021 | Signed as free agent | Edwin Sanchez | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent OF Edwin Sanchez to a minor league contract. |
| Sep 7, 2021 | Signed as free agent | Jose Alifonso | — | San Francisco Giants | San Francisco Giants signed free agent 2B Jose Alifonso to a minor league contract. |
| Sep 6, 2021 | Signed as free agent | Jose Iglesias | — | Boston Red Sox | Boston Red Sox signed free agent SS Jose Iglesias. |
| Sep 6, 2021 | Signed as free agent | Jorge Marcheco | — | Los Angeles Angels | Los Angeles Angels signed free agent RHP Jorge Marcheco to a minor league contract. |
| Sep 6, 2021 | Signed as free agent | Anthony Scull | — | Los Angeles Angels | Los Angeles Angels signed free agent OF Anthony Scull to a minor league contract. |
| Sep 6, 2021 | Signed as free agent | Fausto Pediet | — | Seattle Mariners | Seattle Mariners signed free agent RHP Fausto Pediet to a minor league contract. |
| Sep 5, 2021 | Signed as free agent | Rubén Tejada | — | Chicago White Sox | Chicago White Sox signed free agent SS Ruben Tejada to a minor league contract. |
| Sep 5, 2021 | Signed as free agent | Drake Nightengale | — | Chicago White Sox | Chicago White Sox signed free agent RHP Drake Nightengale to a minor league contract. |
| Sep 5, 2021 | Signed as free agent | Conner O'Neil | — | Chicago White Sox | Chicago White Sox signed free agent RHP Conner O'Neil to a minor league contract. |
| Sep 4, 2021 | Signed as free agent | Chase Plymell | — | Chicago White Sox | Chicago White Sox signed free agent RHP Chase Plymell to a minor league contract. |
| Sep 3, 2021 | Signed as free agent | Domingo Leyba | — | Texas Rangers | Texas Rangers signed free agent SS Domingo Leyba to a minor league contract. |
| Sep 3, 2021 | Released | Jose Iglesias | — | Los Angeles Angels | Los Angeles Angels released SS Jose Iglesias. |
| Sep 3, 2021 | Released | Starlin Castro | — | Washington Nationals | Washington Nationals released SS Starlin Castro. |
| Sep 3, 2021 | Signed as free agent | Luis Hernandez | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP Luis Hernandez to a minor league contract. |
| Sep 3, 2021 | Signed as free agent | Victor Cabreja | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent LHP Victor Cabreja to a minor league contract. |
| Sep 3, 2021 | Signed as free agent | Brandison Polanco | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent RHP Brandison Polanco to a minor league contract. |
| Sep 1, 2021 | Trade | J.J. D'Orazio | Toronto Blue Jays | Arizona Diamondbacks | Toronto Blue Jays traded LHP Yaifer Perdomo and C J.J. D'Orazio to Arizona Diamondbacks. |
| Sep 1, 2021 | Signed as free agent | Zach Lee | — | Cincinnati Reds | Cincinnati Reds signed free agent RHP Zach Lee to a minor league contract. |
| Sep 1, 2021 | Signed as free agent | Keon Broxton | — | Milwaukee Brewers | Milwaukee Brewers signed free agent CF Keon Broxton to a minor league contract. |
| Sep 1, 2021 | Signed as free agent | Jake Suddreth | — | Chicago White Sox | Chicago White Sox signed free agent RHP Jake Suddreth to a minor league contract. |
| Aug 31, 2021 | Trade | Delino DeShields | Boston Red Sox | Cincinnati Reds | Boston Red Sox traded CF Delino DeShields to Cincinnati Reds for cash. |
| Aug 31, 2021 | Signed as free agent | Chase Anderson | — | Texas Rangers | Texas Rangers signed free agent RHP Chase Anderson to a minor league contract. |
| Aug 31, 2021 | Signed | Owen Holt | — | Cincinnati Reds | Cincinnati Reds signed RHP Owen Holt. |
| Aug 31, 2021 | Signed as free agent | Drew Butera | — | Houston Astros | Houston Astros signed free agent C Drew Butera to a minor league contract. |
| Aug 31, 2021 | Signed as free agent | Vinny Nittoli | — | Minnesota Twins | Minnesota Twins signed free agent RHP Vinny Nittoli to a minor league contract. |
| Aug 31, 2021 | Signed as free agent | Aaron Slegers | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP Aaron Slegers to a minor league contract. |
| Aug 31, 2021 | Signed as free agent | Carl Edwards Jr. | — | Chicago White Sox | Chicago White Sox signed free agent RHP Carl Edwards Jr. to a minor league contract. |
| Aug 31, 2021 | Signed as free agent | Gregory Polanco | — | Toronto Blue Jays | Toronto Blue Jays signed free agent RF Gregory Polanco to a minor league contract. |
| Aug 31, 2021 | Trade | Stevie Berman | Los Angeles Dodgers | Minnesota Twins | Minnesota Twins traded LHP Andrew Vasquez to Los Angeles Dodgers for C Stevie Berman. |
| Aug 31, 2021 | Signed as free agent | Jose Nova | — | Boston Red Sox | Boston Red Sox signed free agent RHP Jose Nova to a minor league contract. |
| Aug 31, 2021 | Signed as free agent | Maikel Franco | — | Atlanta Braves | Atlanta Braves signed free agent 3B Maikel Franco to a minor league contract. |
| Aug 31, 2021 | Signed as free agent | Marcelo Valladares | — | Chicago White Sox | Chicago White Sox signed free agent RHP Marcelo Valladares to a minor league contract. |
| Aug 31, 2021 | Signed as free agent | Miguel Perez | — | Atlanta Braves | Atlanta Braves signed free agent RHP Miguel Perez to a minor league contract. |
| Aug 31, 2021 | Signed as free agent | Yoerison Cepeda | — | New York Mets | New York Mets signed free agent RHP Yoerison Cepeda to a minor league contract. |
| Aug 30, 2021 | Signed as free agent | Renato Núñez | — | Milwaukee Brewers | Milwaukee Brewers signed free agent 3B Renato Nunez to a minor league contract. |
| Aug 30, 2021 | Trade | Jason Parker | Cincinnati Reds | New York Yankees | Cincinnati Reds traded RHP Jason Parker to New York Yankees. |
| Aug 30, 2021 | Trade | Brad Peacock | Cleveland Guardians | Boston Red Sox | Cleveland Indians traded RHP Brad Peacock to Boston Red Sox for cash. |
| Aug 30, 2021 | Signed as free agent | Elvis Luciano | — | Toronto Blue Jays | Toronto Blue Jays signed free agent RHP Elvis Luciano to a minor league contract. |
| Aug 30, 2021 | Signed as free agent | Josue Carmona | — | Washington Nationals | Washington Nationals signed free agent LHP Josue Carmona to a minor league contract. |
| Aug 29, 2021 | Released | Bryan Holaday | — | Arizona Diamondbacks | Arizona Diamondbacks released C Bryan Holaday. |
| Aug 29, 2021 | Signed as free agent | Wyatt Mathisen | — | San Francisco Giants | San Francisco Giants signed free agent 3B Wyatt Mathisen to a minor league contract. |
| Aug 29, 2021 | Released | Carl Edwards Jr. | — | Toronto Blue Jays | Toronto Blue Jays released RHP Carl Edwards Jr.. |
| Aug 28, 2021 | Released | Erasmo Ramírez | — | Detroit Tigers | Detroit Tigers released RHP Erasmo Ramirez. |
| Aug 28, 2021 | Signed as free agent | Michael Feliz | — | Boston Red Sox | Boston Red Sox signed free agent RHP Michael Feliz to a minor league contract. |
| Aug 27, 2021 | Signed as free agent | Marwin Gonzalez | — | Houston Astros | Houston Astros signed free agent SS Marwin Gonzalez to a minor league contract. |
| Aug 27, 2021 | Signed as free agent | Chris Jefferson | — | Seattle Mariners | Seattle Mariners signed free agent RHP Chris Jefferson to a minor league contract. |
| Aug 27, 2021 | Released | Chase Anderson | — | Philadelphia Phillies | Philadelphia Phillies released RHP Chase Anderson. |
| Aug 27, 2021 | Signed | Dennis Boatman | — | Cincinnati Reds | Cincinnati Reds signed RHP Dennis Boatman. |
| Aug 27, 2021 | Signed as free agent | Carlos Oviedo | — | New York Mets | New York Mets signed free agent C Carlos Oviedo to a minor league contract. |
| Aug 27, 2021 | Signed as free agent | Jorge Nunez | — | Texas Rangers | Texas Rangers signed free agent RHP Jorge Nunez to a minor league contract. |
| Aug 27, 2021 | Signed as free agent | Pedro Garcia | — | Detroit Tigers | Detroit Tigers signed free agent RHP Pedro Garcia to a minor league contract. |
| Aug 26, 2021 | Signed | Julian Aguiar | — | Cincinnati Reds | Cincinnati Reds signed RHP Julian Aguiar. |
| Aug 26, 2021 | Signed as free agent | Candido Cuevas | — | New York Mets | New York Mets signed free agent RHP Candido Cuevas to a minor league contract. |
| Aug 25, 2021 | Released | Michael Feliz | — | Cincinnati Reds | Cincinnati Reds released RHP Michael Feliz. |
| Aug 25, 2021 | Released | Maikel Franco | — | Baltimore Orioles | Baltimore Orioles released 3B Maikel Franco. |
| Aug 25, 2021 | Signed as free agent | Ricardito Lorenzo | — | Kansas City Royals | Kansas City Royals signed free agent LHP Ricardito Lorenzo to a minor league contract. |
| Aug 25, 2021 | Signed as free agent | David Rodriguez | — | Kansas City Royals | Kansas City Royals signed free agent LHP David Rodriguez to a minor league contract. |
| Aug 24, 2021 | Signed as free agent | Cody Carroll | — | Miami Marlins | Miami Marlins signed free agent RHP Cody Carroll to a minor league contract. |
| Aug 24, 2021 | Signed as free agent | Tommy Milone | — | Cincinnati Reds | Cincinnati Reds signed free agent LHP Tommy Milone to a minor league contract. |
| Aug 24, 2021 | Signed as free agent | Taylor Guerrieri | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RHP Taylor Guerrieri to a minor league contract. |
| Aug 24, 2021 | Signed | Thomas Farr | — | Cincinnati Reds | Cincinnati Reds signed RHP Thomas Farr. |
| Aug 23, 2021 | Released | Elvis Luciano | — | Toronto Blue Jays | Toronto Blue Jays released RHP Elvis Luciano. |
| Aug 23, 2021 | Signed as free agent | Adam McKillican | — | Texas Rangers | Texas Rangers signed free agent RHP Adam McKillican to a minor league contract. |
| Aug 23, 2021 | Signed as free agent | Jesus D. Castro | — | San Diego Padres | San Diego Padres signed free agent C Jesus Castro to a minor league contract. |
| Aug 23, 2021 | Signed as free agent | Jonathan Almonte | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Jonathan Almonte to a minor league contract. |
| Aug 22, 2021 | Signed as free agent | Matt Andriese | — | Seattle Mariners | Seattle Mariners signed free agent RHP Matt Andriese. |
| Aug 21, 2021 | Signed as free agent | Buck Farmer | — | Texas Rangers | Texas Rangers signed free agent RHP Buck Farmer to a minor league contract. |
| Aug 21, 2021 | Signed as free agent | Oscar Campos | — | New York Mets | New York Mets signed free agent C Oscar Campos to a minor league contract. |
| Aug 20, 2021 | Released | Dan Winkler | — | Chicago Cubs | Chicago Cubs released RHP Dan Winkler. |
| Aug 20, 2021 | Signed as free agent | David Hess | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP David Hess to a minor league contract. |
| Aug 20, 2021 | Released | Adam Eaton | — | Los Angeles Angels | Los Angeles Angels released CF Adam Eaton. |
| Aug 20, 2021 | Signed as free agent | Shane Greene | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Shane Greene. |
| Aug 20, 2021 | Signed as free agent | Brandon Trammell | — | San Diego Padres | San Diego Padres signed free agent RHP Brandon Trammell to a minor league contract. |
| Aug 20, 2021 | Signed as free agent | Santiago Sojo | — | San Diego Padres | San Diego Padres signed free agent RHP Santiago Sojo to a minor league contract. |
| Aug 19, 2021 | Signed | Jordan Leasure | — | Los Angeles Dodgers | Los Angeles Dodgers signed RHP Jordan Leasure. |
| Aug 19, 2021 | Signed as free agent | Marcus Walden | — | Chicago Cubs | Chicago Cubs signed free agent RHP Marcus Walden to a minor league contract. |
| Aug 19, 2021 | Signed | Justin Farmer | — | San Diego Padres | San Diego Padres signed OF Justin Farmer. |
| Aug 19, 2021 | Released | Matt Andriese | — | Boston Red Sox | Boston Red Sox released RHP Matt Andriese. |
| Aug 18, 2021 | Trade | Dustin Garneau | Colorado Rockies | Detroit Tigers | Colorado Rockies traded C Dustin Garneau, and to Detroit Tigers. |
| Aug 18, 2021 | Signed as free agent | Tyler Viza | — | San Diego Padres | San Diego Padres signed free agent RHP Tyler Viza to a minor league contract. |
| Aug 18, 2021 | Signed | Dustin Saenz | — | Washington Nationals | Washington Nationals signed LHP Dustin Saenz. |
| Aug 18, 2021 | Signed as free agent | Blake Seigler | — | Los Angeles Angels | Los Angeles Angels signed free agent RHP Blake Seigler to a minor league contract. |
| Aug 18, 2021 | Signed as free agent | Yoryi Jimenez | — | Seattle Mariners | Seattle Mariners signed free agent RHP Yoryi Jimenez to a minor league contract. |
| Aug 17, 2021 | Released | Buck Farmer | — | Detroit Tigers | Detroit Tigers released RHP Buck Farmer. |
| Aug 17, 2021 | Signed as free agent | David Dahl | — | Milwaukee Brewers | Milwaukee Brewers signed free agent LF David Dahl to a minor league contract. |
| Aug 17, 2021 | Signed as free agent | Elijah Greene | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent OF Elijah Greene to a minor league contract. |
| Aug 17, 2021 | Signed as free agent | Max Hewitt | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent C Max Hewitt to a minor league contract. |
| Aug 16, 2021 | Signed as free agent | David Robertson | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP David Robertson. |
| Aug 16, 2021 | Signed as free agent | Jake Arrieta | — | San Diego Padres | San Diego Padres signed free agent RHP Jake Arrieta to a minor league contract. |
| Aug 16, 2021 | Released | Marwin Gonzalez | — | Boston Red Sox | Boston Red Sox released SS Marwin Gonzalez. |
| Aug 16, 2021 | Signed as free agent | Jimmy Herget | — | Los Angeles Angels | Los Angeles Angels signed free agent RHP Jimmy Herget to a minor league contract. |
| Aug 16, 2021 | Signed | Yoshi Tsutsugo | — | Pittsburgh Pirates | Pittsburgh Pirates signed LF Yoshi Tsutsugo. |
| Aug 16, 2021 | Signed | Steven Williams | — | Washington Nationals | Washington Nationals signed C Steven Williams. |
| Aug 16, 2021 | Signed | Andrew Alvarez | — | Washington Nationals | Washington Nationals signed LHP Andrew Alvarez. |
| Aug 16, 2021 | Signed | Brendan Collins | — | Washington Nationals | Washington Nationals signed RHP Brendan Collins. |
| Aug 16, 2021 | Signed | Darren Baker | — | Washington Nationals | Washington Nationals signed 2B Darren Baker. |
| Aug 16, 2021 | Signed | Will Frizzell | — | Washington Nationals | Washington Nationals signed 1B Will Frizzell. |
| Aug 16, 2021 | Signed as free agent | Nicolas Deschamps | — | Toronto Blue Jays | Toronto Blue Jays signed free agent C Nicolas Deschamps to a minor league contract. |
| Aug 16, 2021 | Signed as free agent | Andres Sosa | — | Toronto Blue Jays | Toronto Blue Jays signed free agent C Andres Sosa to a minor league contract. |
| Aug 16, 2021 | Signed as free agent | Ian Foggo | — | Houston Astros | Houston Astros signed free agent RHP Ian Foggo to a minor league contract. |
| Aug 16, 2021 | Signed as free agent | Angel Rivera | — | Athletics | Oakland Athletics signed free agent C Angel Rivera to a minor league contract. |
| Aug 16, 2021 | Signed | Kenny Piper | — | Tampa Bay Rays | Tampa Bay Rays signed C Kenny Piper. |
| Aug 16, 2021 | Signed | Marc Davis | — | Washington Nationals | Washington Nationals signed RHP Marc Davis. |
| Aug 16, 2021 | Signed | Yoshi Tsutsugo | — | Pittsburgh Pirates | Pittsburgh Pirates signed LF Yoshi Tsutsugo. |
| Aug 16, 2021 | Signed | Yoshi Tsutsugo | — | Pittsburgh Pirates | Pittsburgh Pirates signed LF Yoshi Tsutsugo. |
| Aug 14, 2021 | Released | Shane Greene | — | Atlanta Braves | Atlanta Braves released RHP Shane Greene. |
| Aug 14, 2021 | Signed | Ryan Cardona | — | Cincinnati Reds | Cincinnati Reds signed RHP Ryan Cardona. |
| Aug 14, 2021 | Signed as free agent | Sal Romano | — | New York Yankees | New York Yankees signed free agent RHP Sal Romano to a minor league contract. |
| Aug 14, 2021 | Signed | Donovan Benoit | — | Cincinnati Reds | Cincinnati Reds signed RHP Donovan Benoit. |
| Aug 14, 2021 | Trade | Mallex Smith | Cincinnati Reds | Toronto Blue Jays | Cincinnati Reds traded CF Mallex Smith to Toronto Blue Jays. |
| Aug 14, 2021 | Released | René Rivera | — | Washington Nationals | Washington Nationals released C Rene Rivera. |
| Aug 13, 2021 | Signed as free agent | Dustin Fowler | — | Miami Marlins | Miami Marlins signed free agent CF Dustin Fowler to a minor league contract. |
| Aug 13, 2021 | Signed as free agent | Robbie Baker | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Robbie Baker to a minor league contract. |
| Aug 13, 2021 | Signed as free agent | Josh Reddick | — | New York Mets | New York Mets signed free agent RF Josh Reddick to a minor league contract. |
| Aug 13, 2021 | Released | Aaron Sanchez | — | San Francisco Giants | San Francisco Giants released RHP Aaron Sanchez. |
| Aug 13, 2021 | Signed as free agent | James Meeker | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP James Meeker to a minor league contract. |
| Aug 13, 2021 | Signed as free agent | Colin Rea | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Colin Rea to a minor league contract. |
| Aug 13, 2021 | Signed as free agent | Jean Calderon | — | New York Mets | New York Mets signed free agent RHP Jean Calderon to a minor league contract. |
| Aug 12, 2021 | Released | Jake Arrieta | — | Chicago Cubs | Chicago Cubs released RHP Jake Arrieta. |
| Aug 12, 2021 | Signed | Justice Thompson | — | Cincinnati Reds | Cincinnati Reds signed OF Justice Thompson. |
| Aug 12, 2021 | Signed | Jose Torres | — | Cincinnati Reds | Cincinnati Reds signed SS Jose Torres. |
| Aug 12, 2021 | Signed | Ryan Bergert | — | San Diego Padres | San Diego Padres signed RHP Ryan Bergert. |
| Aug 12, 2021 | Signed as free agent | Matt Sparling | — | San Diego Padres | San Diego Padres signed free agent LHP Matt Sparling to a minor league contract. |
| Aug 11, 2021 | Signed as free agent | Connor Sadzeck | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Connor Sadzeck to a minor league contract. |
| Aug 11, 2021 | Signed as free agent | A.J. Labas | — | Minnesota Twins | Minnesota Twins signed free agent RHP A.J. Labas to a minor league contract. |
| Aug 11, 2021 | Signed as free agent | Logan Campbell | — | Minnesota Twins | Minnesota Twins signed free agent RHP Logan Campbell to a minor league contract. |
| Aug 11, 2021 | Signed | Austin Callahan | — | Cincinnati Reds | Cincinnati Reds signed 3B Austin Callahan. |
| Aug 11, 2021 | Signed as free agent | Carlos Perez | — | Colorado Rockies | Colorado Rockies signed free agent RHP Carlos Perez to a minor league contract. |
| Aug 11, 2021 | Signed as free agent | Griffin Lockwood-Powell | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent C Griffin Lockwood-Powell to a minor league contract. |
| Aug 11, 2021 | Signed as free agent | Jan Nunez | — | Kansas City Royals | Kansas City Royals signed free agent LHP Jan Nunez to a minor league contract. |
| Aug 10, 2021 | Signed | Mat Nelson | — | Cincinnati Reds | Cincinnati Reds signed C Matheu Nelson. |
| Aug 10, 2021 | Released | Tommy Milone | — | Toronto Blue Jays | Toronto Blue Jays released LHP Tommy Milone. |
| Aug 10, 2021 | Signed as free agent | Alex Claudio | — | Boston Red Sox | Boston Red Sox signed free agent LHP Alex Claudio to a minor league contract. |
| Aug 10, 2021 | Signed | Holt Jones | — | Miami Marlins | Miami Marlins signed RHP Holt Jones Jr.. |
| Aug 10, 2021 | Signed | Tyler Eckberg | — | Miami Marlins | Miami Marlins signed RHP Tyler Eckberg. |
| Aug 10, 2021 | Signed as free agent | Ruben Ramirez | — | Kansas City Royals | Kansas City Royals signed free agent RHP Ruben Ramirez to a minor league contract. |
| Aug 10, 2021 | Signed as free agent | Zach McAllister | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RHP Zach McAllister to a minor league contract. |
| Aug 10, 2021 | Signed as free agent | Joe Kemlage | — | San Francisco Giants | San Francisco Giants signed free agent LHP Joseph Kemlage to a minor league contract. |
| Aug 9, 2021 | Released | Luis González | — | Chicago White Sox | Chicago White Sox released OF Luis Gonzalez. |
| Aug 9, 2021 | Signed as free agent | Tony Wolters | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent C Tony Wolters to a minor league contract. |
| Aug 9, 2021 | Signed as free agent | Felix Martinez | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent LHP Felix Martinez to a minor league contract. |
| Aug 9, 2021 | Signed as free agent | Leandro Mejia | — | New York Mets | New York Mets signed free agent RHP Leandro Mejia to a minor league contract. |
| Aug 9, 2021 | Signed as free agent | Raimon Gomez | — | New York Mets | New York Mets signed free agent RHP Raimon Gomez to a minor league contract. |
| Aug 9, 2021 | Signed as free agent | Andy Rodriguez | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP Andy Rodriguez to a minor league contract. |
| Aug 9, 2021 | Signed as free agent | Hayden Seig | — | Los Angeles Angels | Los Angeles Angels signed free agent RHP Hayden Seig to a minor league contract. |
| Aug 8, 2021 | Signed | Sean Hunley | — | Tampa Bay Rays | Tampa Bay Rays signed RHP Sean Hunley. |
| Aug 8, 2021 | Signed | Kyle Manzardo | — | Tampa Bay Rays | Tampa Bay Rays signed 1B Kyle Manzardo. |
| Aug 8, 2021 | Signed | Dru Baker | — | Tampa Bay Rays | Tampa Bay Rays signed OF Dru Baker. |
| Aug 8, 2021 | Signed | Patrick Wicklander | — | Tampa Bay Rays | Tampa Bay Rays signed LHP Patrick Wicklander. |
| Aug 8, 2021 | Signed | Mason Montgomery | — | Tampa Bay Rays | Tampa Bay Rays signed LHP Mason Montgomery. |
| Aug 8, 2021 | Signed | Logan Workman | — | Tampa Bay Rays | Tampa Bay Rays signed RHP Logan Workman. |
| Aug 8, 2021 | Signed as free agent | Zac Fascia | — | Cleveland Guardians | Cleveland Indians signed free agent C Zac Fascia to a minor league contract. |
| Aug 8, 2021 | Signed as free agent | Damon Dues | — | San Francisco Giants | San Francisco Giants signed free agent SS Damon Dues to a minor league contract. |
| Aug 8, 2021 | Signed | William Fleming | — | Seattle Mariners | Seattle Mariners signed RHP William Fleming. |
| Aug 7, 2021 | Trade | T.J. Rivera | Pittsburgh Pirates | Philadelphia Phillies | Pittsburgh Pirates traded 2B T.J. Rivera to Philadelphia Phillies. |
| Aug 7, 2021 | Signed as free agent | Nick Tropeano | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Nick Tropeano to a minor league contract. |
| Aug 7, 2021 | Released | Josh Reddick | — | Arizona Diamondbacks | Arizona Diamondbacks released RF Josh Reddick. |
| Aug 7, 2021 | Signed as free agent | Zack Godley | — | New York Mets | New York Mets signed free agent RHP Zack Godley to a minor league contract. |
| Aug 6, 2021 | Signed | Ryan Och | — | San Diego Padres | San Diego Padres signed LHP Ryan Och. |
| Aug 6, 2021 | Released | David Dahl | — | Texas Rangers | Texas Rangers released LF David Dahl. |
| Aug 6, 2021 | Signed as free agent | Jose Flores | — | Colorado Rockies | Colorado Rockies signed free agent RHP Jose Flores to a minor league contract. |
| Aug 6, 2021 | Signed | Anyer Laureano | — | Cincinnati Reds | Cincinnati Reds signed RHP Anyer Laureano. |
| Aug 5, 2021 | Signed as free agent | Ender Inciarte | — | Cincinnati Reds | Cincinnati Reds signed free agent CF Ender Inciarte to a minor league contract. |
| Aug 5, 2021 | Signed as free agent | Hayden Jones | — | Cincinnati Reds | Cincinnati Reds signed free agent C Hayden Jones to a minor league contract. |
| Aug 5, 2021 | Signed | Josh Crouch | — | Detroit Tigers | Detroit Tigers signed C Josh Crouch. |
| Aug 5, 2021 | Signed as free agent | Coltyn Kessler | — | Miami Marlins | Miami Marlins signed free agent C Coltyn Kessler to a minor league contract. |
| Aug 5, 2021 | Signed | Sam Praytor | — | Miami Marlins | Miami Marlins signed C Sam Praytor. |
| Aug 5, 2021 | Signed | Cody Morissette | — | Miami Marlins | Miami Marlins signed SS Cody Morissette. |
| Aug 5, 2021 | Signed | John Rhodes | — | Baltimore Orioles | Baltimore Orioles signed OF John Rhodes. |
| Aug 5, 2021 | Signed | Trendon Craig | — | Baltimore Orioles | Baltimore Orioles signed OF Trendon Craig. |
| Aug 5, 2021 | Signed | Donta' Williams | — | Baltimore Orioles | Baltimore Orioles signed OF Donta' Williams. |
| Aug 5, 2021 | Signed as free agent | Jordan Carr | — | Minnesota Twins | Minnesota Twins signed free agent LHP Jordan Carr to a minor league contract. |
| Aug 5, 2021 | Signed as free agent | Tyler Chatwood | — | San Francisco Giants | San Francisco Giants signed free agent RHP Tyler Chatwood to a minor league contract. |
| Aug 4, 2021 | Signed as free agent | Khris Davis | — | Athletics | Oakland Athletics signed free agent LF Khris Davis to a minor league contract. |
| Aug 4, 2021 | Signed as free agent | Cole Hamels | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent LHP Cole Hamels. |
| Aug 4, 2021 | Signed as free agent | Evan Phillips | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP Evan Phillips to a minor league contract. |
| Aug 4, 2021 | Trade | Delino DeShields | Texas Rangers | Boston Red Sox | Texas Rangers traded CF Delino DeShields to Boston Red Sox for cash. |
| Aug 4, 2021 | Signed as free agent | Austin Gauthier | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent SS Austin Gauthier to a minor league contract. |
| Aug 4, 2021 | Signed as free agent | Jairo Castillo | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Jairo Castillo to a minor league contract. |
| Aug 4, 2021 | Signed as free agent | Dencer Geraldo | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Dencer Geraldo to a minor league contract. |
| Aug 4, 2021 | Signed as free agent | Anfernny Reyes | — | Milwaukee Brewers | Milwaukee Brewers signed free agent LHP Anfernny Reyes to a minor league contract. |
| Aug 4, 2021 | Signed as free agent | Aaron Cohn | — | Athletics | Oakland Athletics signed free agent RHP Aaron Cohn to a minor league contract. |
| Aug 4, 2021 | Signed as free agent | José De León | — | Boston Red Sox | Boston Red Sox signed free agent RHP Jose De Leon to a minor league contract. |
| Aug 3, 2021 | Trade | Kellin Deglan | New York Yankees | Toronto Blue Jays | New York Yankees traded C Kellin Deglan to Toronto Blue Jays. |
| Aug 3, 2021 | Signed as free agent | Keury Mella | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent RHP Keury Mella to a minor league contract. |
| Aug 3, 2021 | Signed as free agent | Jack Dreyer | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent LHP Jack Dreyer to a minor league contract. |
| Aug 3, 2021 | Signed as free agent | Orlando Ortiz-Mayr | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Orlando Ortiz-Mayr to a minor league contract. |
| Aug 3, 2021 | Signed as free agent | Antonio Millan | — | San Francisco Giants | San Francisco Giants signed free agent LHP Antonio Millan to a minor league contract. |
| Aug 3, 2021 | Signed as free agent | Jilber Canas | — | San Francisco Giants | San Francisco Giants signed free agent RHP Jilber Canas to a minor league contract. |
| Aug 3, 2021 | Signed as free agent | Luis Ochoa | — | San Francisco Giants | San Francisco Giants signed free agent LHP Luis Ochoa to a minor league contract. |
| Aug 3, 2021 | Signed as free agent | Brayan Cabello | — | San Francisco Giants | San Francisco Giants signed free agent RHP Brayan Cabello to a minor league contract. |
| Aug 3, 2021 | Signed as free agent | Khristian Guevara | — | Cincinnati Reds | Cincinnati Reds signed free agent LHP Khristian Guevara to a minor league contract. |
| Aug 2, 2021 | Signed as free agent | Calvin Starnes | — | New York Yankees | New York Yankees signed free agent RHP Calvin Starnes to a minor league contract. |
| Aug 2, 2021 | Trade | John Axford | Toronto Blue Jays | Milwaukee Brewers | Toronto Blue Jays traded RHP John Axford to Milwaukee Brewers for cash. |
| Aug 2, 2021 | Signed as free agent | Domingo Acevedo | — | Athletics | Oakland Athletics signed free agent RHP Domingo Acevedo to a minor league contract. |
| Aug 2, 2021 | Released | Brandon Kintzler | — | Philadelphia Phillies | Philadelphia Phillies released RHP Brandon Kintzler. |
| Aug 2, 2021 | Signed as free agent | Peyton Glavine | — | Washington Nationals | Washington Nationals signed free agent LHP Peyton Glavine to a minor league contract. |
| Aug 2, 2021 | Signed as free agent | Cody Greenhill | — | Washington Nationals | Washington Nationals signed free agent RHP Cody Greenhill to a minor league contract. |
| Aug 2, 2021 | Signed as free agent | Tyler Schoff | — | Washington Nationals | Washington Nationals signed free agent RHP Tyler Schoff to a minor league contract. |
| Aug 2, 2021 | Signed as free agent | Gunner Halter | — | Washington Nationals | Washington Nationals signed free agent SS Gunner Halter to a minor league contract. |
| Aug 2, 2021 | Signed as free agent | Jake Sullivan | — | Washington Nationals | Washington Nationals signed free agent C Jake Sullivan to a minor league contract. |
| Aug 2, 2021 | Signed as free agent | Luis Marine | — | Baltimore Orioles | Baltimore Orioles signed free agent RHP Luis Marine to a minor league contract. |
| Aug 1, 2021 | Signed | Aaron Zavala | — | Texas Rangers | Texas Rangers signed OF Aaron Zavala. |
| Aug 1, 2021 | Signed | Tucker Mitchell | — | Texas Rangers | Texas Rangers signed C Tucker Mitchell. |
| Aug 1, 2021 | Signed | Kyle Larsen | — | Texas Rangers | Texas Rangers signed RHP Kyle Larsen. |
| Aug 1, 2021 | Signed | Nathan Hickey | — | Boston Red Sox | Boston Red Sox signed C Nathan Hickey. |
| Aug 1, 2021 | Signed | Niko Kavadas | — | Boston Red Sox | Boston Red Sox signed 1B Niko Kavadas. |
| Aug 1, 2021 | Signed | Luis Guerrero | — | Boston Red Sox | Boston Red Sox signed RHP Luis Guerrero. |
| Aug 1, 2021 | Signed | Kahlil Watson | — | Miami Marlins | Miami Marlins signed SS Kahlil Watson. |
| Aug 1, 2021 | Signed | Noah Williamson | — | Miami Marlins | Miami Marlins signed OF Noah Williamson. |
| Aug 1, 2021 | Signed | Quinton Low | — | Milwaukee Brewers | Milwaukee Brewers signed RHP Quinton Low. |
| Aug 1, 2021 | Signed | Caden Vire | — | Milwaukee Brewers | Milwaukee Brewers signed LHP Caden Vire. |
| Jul 31, 2021 | Signed as free agent | Jon Duplantier | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Jon Duplantier to a minor league contract. |
| Jul 31, 2021 | Signed | Jordan Lawlar | — | Arizona Diamondbacks | Arizona Diamondbacks signed SS Jordan Lawlar. |
| Jul 31, 2021 | Signed | Damiano Palmegiani | — | Toronto Blue Jays | Toronto Blue Jays signed 3B Damiano Palmegiani. |
| Jul 31, 2021 | Signed | Cooper Benson | — | Toronto Blue Jays | Toronto Blue Jays signed LHP Cooper Benson. |
| Jul 31, 2021 | Signed as free agent | Owen Kellington | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent RHP Owen Kellington to a minor league contract. |
| Jul 31, 2021 | Released | Domingo Acevedo | — | Athletics | Oakland Athletics released RHP Domingo Acevedo. |
| Jul 31, 2021 | Released | Tyler Chatwood | — | Toronto Blue Jays | Toronto Blue Jays released RHP Tyler Chatwood. |
| Jul 31, 2021 | Signed | Hector Nieves | — | Houston Astros | Houston Astros signed SS Hector G. Nieves. |
| Jul 31, 2021 | Signed | Calvin Ziegler | — | New York Mets | New York Mets signed RHP Calvin Ziegler. |
| Jul 31, 2021 | Signed | Chase Silseth | — | Los Angeles Angels | Los Angeles Angels signed RHP Chase Silseth. |
| Jul 31, 2021 | Signed | Justin Fall | — | Miami Marlins | Miami Marlins signed LHP Justin Fall. |
| Jul 31, 2021 | Signed | Ty Collins | — | Philadelphia Phillies | Philadelphia Phillies signed RHP Ty Collins. |
| Jul 31, 2021 | Signed | Thomas Ireland | — | Texas Rangers | Texas Rangers signed LHP Thomas Ireland. |
| Jul 31, 2021 | Signed | Eric Silva | — | San Francisco Giants | San Francisco Giants signed RHP Eric Silva. |
| Jul 31, 2021 | Signed | Juventino Gonzalez | — | Cincinnati Reds | Cincinnati Reds signed RHP Juventino Gonzalez. |
| Jul 31, 2021 | Signed as free agent | Dayan Reinoso | — | Los Angeles Angels | Los Angeles Angels signed free agent RHP Dayan Reinoso to a minor league contract. |
| Jul 30, 2021 | Trade | Daniel Hudson | Washington Nationals | San Diego Padres | Washington Nationals traded RHP Daniel Hudson to San Diego Padres for RHP Mason Thompson. |
| Jul 30, 2021 | Trade | Shawn Armstrong | Baltimore Orioles | Tampa Bay Rays | Baltimore Orioles traded RHP Shawn Armstrong to Tampa Bay Rays for cash. |
| Jul 30, 2021 | Trade | Abrahan Gutierrez | Philadelphia Phillies | Pittsburgh Pirates | Pittsburgh Pirates traded LHP Braeden Ogle to Philadelphia Phillies for C Abrahan Gutierrez. |
| Jul 30, 2021 | Trade | Simeon Woods Richardson | Toronto Blue Jays | Minnesota Twins | Minnesota Twins traded RHP Jose Berrios to Toronto Blue Jays for SS Austin Martin and RHP Simeon Woods Richardson. |
| Jul 30, 2021 | Trade | Eddie Rosario | Cleveland Guardians | Atlanta Braves | Cleveland Indians traded LF Eddie Rosario and cash to Atlanta Braves for 3B Pablo Sandoval. |
| Jul 30, 2021 | Trade | Adam Duvall | Miami Marlins | Atlanta Braves | Miami Marlins traded LF Adam Duvall to Atlanta Braves for C Alex Jackson. |
| Jul 30, 2021 | Trade | Reese Olson | Milwaukee Brewers | Detroit Tigers | Detroit Tigers traded LHP Daniel Norris to Milwaukee Brewers for RHP Reese Olson. |
| Jul 30, 2021 | Trade | Codi Heuer | Chicago White Sox | Chicago Cubs | Chicago Cubs traded RHP Craig Kimbrel to Chicago White Sox for 2B Nick Madrigal and RHP Codi Heuer. |
| Jul 30, 2021 | Trade | J.A. Happ | Minnesota Twins | St. Louis Cardinals | Minnesota Twins traded LHP J.A. Happ and cash to St. Louis Cardinals for RHP John Gant and LHP Evan Sisk. |
| Jul 30, 2021 | Trade | Max Scherzer | Washington Nationals | Los Angeles Dodgers | Washington Nationals traded RHP Max Scherzer and SS Trea Turner to Los Angeles Dodgers for C Keibert Ruiz, RHP Josiah Gray, RHP Gerardo Carrillo and OF Donovan Casey. |
| Jul 30, 2021 | Trade | Yan Gomes | Washington Nationals | Athletics | Washington Nationals traded C Yan Gomes, 2B Josh Harrison and cash to Oakland Athletics for RHP Richard Guasch, RHP Seth Shuman and C Drew Millas. |
| Jul 30, 2021 | Trade | Phil Maton | Cleveland Guardians | Houston Astros | Cleveland Indians traded RHP Phil Maton and C Yainer Diaz to Houston Astros for RF Myles Straw. |
| Jul 30, 2021 | Trade | Payton Henry | Milwaukee Brewers | Miami Marlins | Miami Marlins traded RHP John Curtiss to Milwaukee Brewers for C Payton Henry. |
| Jul 30, 2021 | Trade | Pete Crow-Armstrong | New York Mets | Chicago Cubs | Chicago Cubs traded SS Javier Baez, RHP Trevor Williams and cash to New York Mets for OF Pete Crow-Armstrong. |
| Jul 30, 2021 | Trade | Jon Lester | Washington Nationals | St. Louis Cardinals | St. Louis Cardinals traded CF Lane Thomas to Washington Nationals for LHP Jon Lester. |
| Jul 30, 2021 | Trade | Kasey Kalich | Atlanta Braves | Kansas City Royals | Kansas City Royals traded RF Jorge Soler to Atlanta Braves for RHP Kasey Kalich. |
| Jul 30, 2021 | Trade | Bryse Wilson | Atlanta Braves | Pittsburgh Pirates | Pittsburgh Pirates traded RHP Richard Rodriguez to Atlanta Braves for RHP Bryse Wilson and RHP Ricky DeVito. |
| Jul 30, 2021 | Trade | Alex Scherff | Boston Red Sox | Minnesota Twins | Minnesota Twins traded RHP Hansel Robles to Boston Red Sox for RHP Alex Scherff. |
| Jul 30, 2021 | Trade | Joakim Soria | Arizona Diamondbacks | Toronto Blue Jays | Arizona Diamondbacks traded RHP Joakim Soria to Toronto Blue Jays for Player To Be Named Later and Player To Be Named Later. |
| Jul 30, 2021 | Trade | Austin Davis | Pittsburgh Pirates | Boston Red Sox | Pittsburgh Pirates traded LHP Austin Davis to Boston Red Sox for 2B Michael Chavis. |
| Jul 30, 2021 | Trade | Peyton Battenfield | Tampa Bay Rays | Cleveland Guardians | Cleveland Indians traded LF Jordan Luplow and RHP DJ Johnson to Tampa Bay Rays for RHP Peyton Battenfield. |
| Jul 30, 2021 | Trade | Spencer Howard | Philadelphia Phillies | Texas Rangers | Texas Rangers traded RHP Hans Crouse, RHP Ian Kennedy, RHP Kyle Gibson and cash to Philadelphia Phillies for RHP Spencer Howard, RHP Josh Gessner and RHP Kevin Gowdy. |
| Jul 30, 2021 | Trade | Freddy Galvis | Baltimore Orioles | Philadelphia Phillies | Baltimore Orioles traded SS Freddy Galvis to Philadelphia Phillies for RHP Tyler Burch. |
| Jul 30, 2021 | Trade | Jake Marisnick | Chicago Cubs | San Diego Padres | San Diego Padres traded RHP Anderson Espinoza to Chicago Cubs for CF Jake Marisnick. |
| Jul 30, 2021 | Trade | Caleb Kilian | San Francisco Giants | Chicago Cubs | Chicago Cubs traded 3B Kris Bryant to San Francisco Giants for LF Alexander Canario and RHP Caleb Kilian. |
| Jul 30, 2021 | Trade | Tony Watson | Los Angeles Angels | San Francisco Giants | Los Angeles Angels traded LHP Tony Watson to San Francisco Giants for LHP Sam Selman, RHP Ivan Armstrong and RHP Jose Marte. |
| Jul 30, 2021 | Trade | Andrew Heaney | Los Angeles Angels | New York Yankees | Los Angeles Angels traded LHP Andrew Heaney and cash to New York Yankees for RHP Janson Junk and RHP Elvis Peguero. |
| Jul 30, 2021 | Signed | A.J. Graham | — | Pittsburgh Pirates | Pittsburgh Pirates signed SS A.J. Graham. |
| Jul 30, 2021 | Released | Pablo Sandoval | — | Cleveland Guardians | Cleveland Indians released 3B Pablo Sandoval. |
| Jul 30, 2021 | Released | Alex Claudio | — | Los Angeles Angels | Los Angeles Angels released LHP Alex Claudio. |
| Jul 30, 2021 | Signed | Jordy Barley | — | Washington Nationals | Washington Nationals signed SS Jordy Barley. |
| Jul 30, 2021 | Signed | Gavin Conticello | — | Arizona Diamondbacks | Arizona Diamondbacks signed 3B Gavin Conticello. |
| Jul 30, 2021 | Signed | Luke Albright | — | Arizona Diamondbacks | Arizona Diamondbacks signed RHP Luke Albright. |
| Jul 30, 2021 | Signed | Scott Randall | — | Arizona Diamondbacks | Arizona Diamondbacks signed RHP Scott Randall. |
| Jul 30, 2021 | Signed | Josh Swales | — | Arizona Diamondbacks | Arizona Diamondbacks signed RHP Josh Swales. |
| Jul 30, 2021 | Signed | Jace Avina | — | Milwaukee Brewers | Milwaukee Brewers signed OF Jace Avina. |
| Jul 30, 2021 | Signed | Christian MacLeod | — | Minnesota Twins | Minnesota Twins signed LHP Christian MacLeod. |
| Jul 30, 2021 | Signed | Edwin Arroyo | — | Seattle Mariners | Seattle Mariners signed SS Edwin Arroyo. |
| Jul 30, 2021 | Signed | Michael Alfonso | — | Texas Rangers | Texas Rangers signed SS Michael Alfonso. |
| Jul 30, 2021 | Signed | JoJo Blackmon | — | Texas Rangers | Texas Rangers signed OF JoJo Blackmon. |
| Jul 30, 2021 | Signed | Evan Elliott | — | Texas Rangers | Texas Rangers signed RHP Evan Elliott. |
| Jul 30, 2021 | Signed | Jackson Leath | — | Texas Rangers | Texas Rangers signed RHP Jackson Leath. |
| Jul 30, 2021 | Signed | Joseph Montalvo | — | Texas Rangers | Texas Rangers signed RHP Joseph Montalvo. |
| Jul 30, 2021 | Signed | Bennett Hostetler | — | Miami Marlins | Miami Marlins signed SS Bennett Hostetler. |
| Jul 30, 2021 | Signed | Jakob Brustoski | — | Milwaukee Brewers | Milwaukee Brewers signed LHP Jakob Brustoski. |
| Jul 30, 2021 | Signed | Chandler Jozwiak | — | Miami Marlins | Miami Marlins signed LHP Chandler Jozwiak. |
| Jul 30, 2021 | Signed as free agent | Walker Powell | — | Chicago Cubs | Chicago Cubs signed free agent RHP Walker Powell to a minor league contract. |
| Jul 30, 2021 | Signed | Eduardo Gonzalez | — | Cincinnati Reds | Cincinnati Reds signed LHP Eduardo Gonzalez. |
| Jul 30, 2021 | Signed | Brady House | — | Washington Nationals | Washington Nationals signed SS Brady House. |
| Jul 29, 2021 | Trade | Brad Hand | Washington Nationals | Toronto Blue Jays | Washington Nationals traded LHP Brad Hand to Toronto Blue Jays for C Riley Adams. |
| Jul 29, 2021 | Trade | Ashton Goudeau | Cincinnati Reds | Colorado Rockies | Cincinnati Reds traded RHP Ashton Goudeau to Colorado Rockies for cash. |
| Jul 29, 2021 | Trade | Josh Smith | New York Yankees | Texas Rangers | New York Yankees traded RHP Glenn Otto, 2B Josh H. Smith, SS Ezequiel Duran and 2B Trevor Hauver to Texas Rangers for LHP Joely Rodriguez, LF Joey Gallo and cash. |
| Jul 29, 2021 | Trade | César Hernández | Cleveland Guardians | Chicago White Sox | Cleveland Indians traded 2B Cesar Hernandez to Chicago White Sox for LHP Konnor Pilkington. |
| Jul 29, 2021 | Released | Tyler Johnson | — | Chicago White Sox | Chicago White Sox released RHP Tyler Johnson. |
| Jul 29, 2021 | Trade | Bailey Horn | Chicago White Sox | Chicago Cubs | Chicago Cubs traded RHP Ryan Tepera to Chicago White Sox for LHP Bailey Horn. |
| Jul 29, 2021 | Released | Ender Inciarte | — | Atlanta Braves | Atlanta Braves released CF Ender Inciarte. |
| Jul 29, 2021 | Signed | Elijah Cabell | — | St. Louis Cardinals | St. Louis Cardinals signed OF Elijah Cabell. |
| Jul 29, 2021 | Signed as free agent | Asher Wojciechowski | — | Seattle Mariners | Seattle Mariners signed free agent RHP Asher Wojciechowski to a minor league contract. |
| Jul 29, 2021 | Signed as free agent | Bryan Mitchell | — | Miami Marlins | Miami Marlins signed free agent RHP Bryan Mitchell to a minor league contract. |
| Jul 29, 2021 | Trade | Austin Shenton | Seattle Mariners | Tampa Bay Rays | Seattle Mariners traded RHP JT Chargois and 3B Austin Shenton to Tampa Bay Rays for RHP Diego Castillo. |
| Jul 29, 2021 | Trade | Danny Duffy | Kansas City Royals | Los Angeles Dodgers | Kansas City Royals traded LHP Danny Duffy and cash to Los Angeles Dodgers for Player To Be Named Later. |
| Jul 29, 2021 | Trade | Alexander Vizcaíno | New York Yankees | Chicago Cubs | New York Yankees traded RHP Alexander Vizcaino and CF Kevin Alcantara to Chicago Cubs for 1B Anthony Rizzo and cash. |
| Jul 29, 2021 | Trade | Aldo Ramirez | Boston Red Sox | Washington Nationals | Washington Nationals traded LF Kyle Schwarber to Boston Red Sox for RHP Aldo Ramirez. |
| Jul 29, 2021 | Signed as free agent | Kyle Crick | — | Chicago White Sox | Chicago White Sox signed free agent RHP Kyle Crick to a minor league contract. |
| Jul 29, 2021 | Signed | Caleb Wurster | — | Miami Marlins | Miami Marlins signed LHP Caleb Wurster. |
| Jul 29, 2021 | Signed | Hunter Perdue | — | Miami Marlins | Miami Marlins signed RHP Hunter Perdue. |
| Jul 29, 2021 | Signed as free agent | Bryce Teodosio | — | Los Angeles Angels | Los Angeles Angels signed free agent OF Bryce Teodosio to a minor league contract. |
| Jul 29, 2021 | Signed | Wilson Cunningham | — | Chicago Cubs | Chicago Cubs signed LHP Wilson Cunningham. |
| Jul 29, 2021 | Signed as free agent | Jared Pettitte | — | Miami Marlins | Miami Marlins signed free agent LHP Jared Pettitte to a minor league contract. |
| Jul 29, 2021 | Signed | Shawn Guilliams | — | Cincinnati Reds | Cincinnati Reds signed RHP Shawn Guilliams. |
| Jul 28, 2021 | Trade | Joaquin Tejada | Seattle Mariners | Pittsburgh Pirates | Pittsburgh Pirates traded LHP Tyler Anderson to Seattle Mariners for C Carter Bins and RHP Joaquin Tejada. |
| Jul 28, 2021 | Trade | Luis Cessa | New York Yankees | Cincinnati Reds | New York Yankees traded LHP Justin Wilson and RHP Luis Cessa to Cincinnati Reds for Player To Be Named Later. |
| Jul 28, 2021 | Signed | Jack Leiter | — | Texas Rangers | Texas Rangers signed RHP Jack Leiter. |
| Jul 28, 2021 | Trade | Case Williams | Cincinnati Reds | Colorado Rockies | Colorado Rockies traded RHP Mychal Givens to Cincinnati Reds for RHP Case Williams and RHP Noah Davis. |
| Jul 28, 2021 | Trade | Jesús Luzardo | Athletics | Miami Marlins | Miami Marlins traded LF Starling Marte to Oakland Athletics for LHP Jesus Luzardo. |
| Jul 28, 2021 | Trade | Yimi García | Miami Marlins | Houston Astros | Houston Astros traded RF Bryan De La Cruz and RHP Austin Pruitt to Miami Marlins for RHP Yimi Garcia. |
| Jul 28, 2021 | Trade | Eduardo Escobar | Arizona Diamondbacks | Milwaukee Brewers | Milwaukee Brewers traded C Cooper Hummel and 2B Alberto Ciprian to Arizona Diamondbacks for 3B Eduardo Escobar. |
| Jul 28, 2021 | Released | Eric Sogard | — | Chicago Cubs | Chicago Cubs released 2B Eric Sogard. |
| Jul 28, 2021 | Signed | Zach Zubia | — | Miami Marlins | Miami Marlins signed 1B Zach Zubia. |
| Jul 28, 2021 | Signed | Tanner Allen | — | Miami Marlins | Miami Marlins signed OF Tanner Allen. |
| Jul 28, 2021 | Signed | Trey Sweeney | — | New York Yankees | New York Yankees signed SS Trey Sweeney. |
| Jul 28, 2021 | Signed | Tyler Hardman | — | New York Yankees | New York Yankees signed 1B Tyler Hardman. |
| Jul 28, 2021 | Signed | Ben Rice | — | New York Yankees | New York Yankees signed C Ben Rice. |
| Jul 28, 2021 | Signed | Grant Richardson | — | New York Yankees | New York Yankees signed OF Grant Richardson. |
| Jul 28, 2021 | Released | Keury Mella | — | Arizona Diamondbacks | Arizona Diamondbacks released RHP Keury Mella. |
| Jul 28, 2021 | Signed as free agent | Quentin Selma | — | Los Angeles Angels | Los Angeles Angels signed free agent 3B Quentin Selma to a minor league contract. |
| Jul 28, 2021 | Signed | River Ryan | — | San Diego Padres | San Diego Padres signed RHP River Ryan. |
| Jul 28, 2021 | Signed | James Wood | — | San Diego Padres | San Diego Padres signed OF James Wood. |
| Jul 28, 2021 | Signed as free agent | Kyle Froemke | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent SS Kyle Froemke to a minor league contract. |
| Jul 28, 2021 | Signed | Dom Hamel | — | New York Mets | New York Mets signed RHP Dominic Hamel. |
| Jul 28, 2021 | Signed | Noah Cardenas | — | Minnesota Twins | Minnesota Twins signed C Noah Cardenas. |
| Jul 28, 2021 | Signed | Donovan McIntyre | — | San Francisco Giants | San Francisco Giants signed OF Donovan McIntyre. |
| Jul 28, 2021 | Signed | Larson Kindreich | — | Texas Rangers | Texas Rangers signed LHP Larson Kindreich. |
| Jul 28, 2021 | Signed as free agent | Ricardo Velez | — | Minnesota Twins | Minnesota Twins signed free agent RHP Ricardo Velez to a minor league contract. |
| Jul 28, 2021 | Signed as free agent | Malik Barrington | — | Minnesota Twins | Minnesota Twins signed free agent RHP Malik Barrington to a minor league contract. |
| Jul 28, 2021 | Signed as free agent | Jackson Hicks | — | Minnesota Twins | Minnesota Twins signed free agent RHP Jackson Hicks to a minor league contract. |
| Jul 28, 2021 | Signed | Peter Heubeck | — | Los Angeles Dodgers | Los Angeles Dodgers signed RHP Peter Heubeck. |
| Jul 28, 2021 | Signed | Tyler Ras | — | Colorado Rockies | Colorado Rockies signed RHP Tyler Ras. |
| Jul 28, 2021 | Signed as free agent | Anddy Flores | — | Boston Red Sox | Boston Red Sox signed free agent LHP Anddy Flores to a minor league contract. |
| Jul 28, 2021 | Signed as free agent | Tommy Gomez | — | New York Mets | New York Mets signed free agent C Tommy Gomez to a minor league contract. |
| Jul 27, 2021 | Signed | Braylon Bishop | — | Pittsburgh Pirates | Pittsburgh Pirates signed OF Braylon Bishop. |
| Jul 27, 2021 | Released | Matt Adams | — | Colorado Rockies | Colorado Rockies released 1B Matt Adams. |
| Jul 27, 2021 | Signed as free agent | Jan Hernandez | — | Cincinnati Reds | Cincinnati Reds signed free agent 3B Jan Hernandez to a minor league contract. |
| Jul 27, 2021 | Trade | Unnamed | — | Seattle Mariners | Houston Astros traded 3B Abraham Toro, RHP Joe Smith, and to Seattle Mariners for RHP Kendall Graveman and RHP Rafael Montero. |
| Jul 27, 2021 | Released | Jon Duplantier | — | Arizona Diamondbacks | Arizona Diamondbacks released RHP Jon Duplantier. |
| Jul 27, 2021 | Signed as free agent | Miguel Toribio | — | Chicago White Sox | Chicago White Sox signed free agent RHP Miguel Toribio to a minor league contract. |
| Jul 27, 2021 | Signed | Braiden Ward | — | Colorado Rockies | Colorado Rockies signed OF Braiden Ward. |
| Jul 27, 2021 | Signed | Trevor Tietz | — | Milwaukee Brewers | Milwaukee Brewers signed RHP Trevor Tietz. |
| Jul 27, 2021 | Signed | Ian Leatherman | — | Tampa Bay Rays | Tampa Bay Rays signed RHP Ian Leatherman. |
| Jul 27, 2021 | Signed as free agent | Fernando Costume | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP Fernando Costume to a minor league contract. |
| Jul 27, 2021 | Signed | Daniel Lloyd | — | Baltimore Orioles | Baltimore Orioles signed RHP Daniel Lloyd. |
| Jul 27, 2021 | Signed | Harry Ford | — | Seattle Mariners | Seattle Mariners signed C Harry Ford. |
| Jul 27, 2021 | Signed | Ryan Spikes | — | Tampa Bay Rays | Tampa Bay Rays signed 2B Ryan Spikes. |
| Jul 27, 2021 | Signed as free agent | Duany Gomez | — | Baltimore Orioles | Baltimore Orioles signed free agent RHP Duany Gomez to a minor league contract. |
| Jul 27, 2021 | Signed | Conor Angel | — | Tampa Bay Rays | Tampa Bay Rays signed RHP Conor Angel. |
| Jul 27, 2021 | Signed as free agent | Luis Frias | — | San Francisco Giants | San Francisco Giants signed free agent OF Luis Frias to a minor league contract. |
| Jul 27, 2021 | Signed as free agent | Shane Smith | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Shane Smith to a minor league contract. |
| Jul 26, 2021 | Signed as free agent | Yonfi Rodriguez | — | Boston Red Sox | Boston Red Sox signed free agent RHP Yonfi Rodriguez to a minor league contract. |
| Jul 26, 2021 | Trade | Tucupita Marcano | San Diego Padres | Pittsburgh Pirates | Pittsburgh Pirates traded 2B Adam Frazier and cash to San Diego Padres for SS Tucupita Marcano, RHP Michell Miliano and CF Jack Suwinski. |
| Jul 26, 2021 | Signed | Denzel Clarke | — | Athletics | Oakland Athletics signed OF Denzel Clarke. |
| Jul 26, 2021 | Signed | Zack Gelof | — | Athletics | Oakland Athletics signed 3B Zack Gelof. |
| Jul 26, 2021 | Signed | CJ Rodriguez | — | Athletics | Oakland Athletics signed C CJ Rodriguez. |
| Jul 26, 2021 | Signed | Dylan Smith | — | Detroit Tigers | Detroit Tigers signed RHP Dylan Smith. |
| Jul 26, 2021 | Signed | Tristan Peters | — | Milwaukee Brewers | Milwaukee Brewers signed OF Tristan Peters. |
| Jul 26, 2021 | Signed | Carlos Rodriguez | — | Milwaukee Brewers | Milwaukee Brewers signed RHP Carlos Rodriguez. |
| Jul 26, 2021 | Trade | Hoy Park | New York Yankees | Pittsburgh Pirates | New York Yankees traded SS Hoy Park and SS Diego Castillo to Pittsburgh Pirates for RHP Clay Holmes. |
| Jul 26, 2021 | Signed | Colton Bender | — | San Diego Padres | San Diego Padres signed C Colton Bender. |
| Jul 26, 2021 | Signed | Lonnie White Jr. | — | Pittsburgh Pirates | Pittsburgh Pirates signed OF Lonnie White Jr.. |
| Jul 26, 2021 | Signed as free agent | Zach Cable | — | Chicago White Sox | Chicago White Sox signed free agent RHP Zach Cable to a minor league contract. |
| Jul 26, 2021 | Signed as free agent | Everhett Hazelwood | — | Chicago White Sox | Chicago White Sox signed free agent RHP Everhett Hazelwood to a minor league contract. |
| Jul 26, 2021 | Signed as free agent | Kohl Simas | — | Chicago White Sox | Chicago White Sox signed free agent RHP Kohl Simas to a minor league contract. |
| Jul 26, 2021 | Signed as free agent | Garrett Schoenle | — | Chicago White Sox | Chicago White Sox signed free agent LHP Garrett Schoenle to a minor league contract. |
| Jul 26, 2021 | Signed as free agent | Nick Thornquist | — | Chicago White Sox | Chicago White Sox signed free agent C Nick Thornquist to a minor league contract. |
| Jul 26, 2021 | Signed | Marcos Castañon | — | San Diego Padres | San Diego Padres signed SS Marcos Castanon. |
| Jul 26, 2021 | Signed as free agent | Cole Cummings | — | San Diego Padres | San Diego Padres signed free agent 3B Cole Cummings to a minor league contract. |
| Jul 26, 2021 | Signed | Lucas Dunn | — | San Diego Padres | San Diego Padres signed 2B Lucas Dunn. |
| Jul 26, 2021 | Signed | Max Ferguson | — | San Diego Padres | San Diego Padres signed 2B Max Ferguson. |
| Jul 26, 2021 | Signed | Jackson Merrill | — | San Diego Padres | San Diego Padres signed SS Jackson Merrill. |
| Jul 26, 2021 | Signed | Chase Petty | — | Minnesota Twins | Minnesota Twins signed RHP Chase Petty. |
| Jul 26, 2021 | Trade | Andrew Chafin | Chicago Cubs | Athletics | Chicago Cubs traded LHP Andrew Chafin to Oakland Athletics for 1B Greg Deichmann and RHP Daniel Palencia. |
| Jul 26, 2021 | Signed | Blake Dunn | — | Cincinnati Reds | Cincinnati Reds signed OF Blake Dunn. |
| Jul 26, 2021 | Signed | Matt McLain | — | Cincinnati Reds | Cincinnati Reds signed SS Matt McLain. |
| Jul 26, 2021 | Signed | Justice Bigbie | — | Detroit Tigers | Detroit Tigers signed 1B Justice Bigbie. |
| Jul 26, 2021 | Signed | Nic Kent | — | Colorado Rockies | Colorado Rockies signed SS Nic Kent. |
| Jul 26, 2021 | Signed | EJ Andrews Jr. | — | Colorado Rockies | Colorado Rockies signed OF EJ Andrews Jr.. |
| Jul 26, 2021 | Signed | Zach Kokoska | — | Colorado Rockies | Colorado Rockies signed OF Zach Kokoska. |
| Jul 26, 2021 | Signed | Robby Martin Jr. | — | Colorado Rockies | Colorado Rockies signed OF Robby Martin Jr.. |
| Jul 26, 2021 | Signed as free agent | Jose Brito | — | Minnesota Twins | Minnesota Twins signed free agent RHP Jose Brito to a minor league contract. |
| Jul 26, 2021 | Signed | Tyler Ahearn | — | Colorado Rockies | Colorado Rockies signed RHP Tyler Ahearn. |
| Jul 26, 2021 | Signed | Jarrod Cande | — | Colorado Rockies | Colorado Rockies signed RHP Jarrod Cande. |
| Jul 26, 2021 | Signed | Mason Green | — | Colorado Rockies | Colorado Rockies signed LHP Mason Green. |
| Jul 26, 2021 | Signed | Cullen Kafka | — | Colorado Rockies | Colorado Rockies signed RHP Cullen Kafka. |
| Jul 26, 2021 | Signed | Evan Shawver | — | Colorado Rockies | Colorado Rockies signed LHP Evan Shawver. |
| Jul 26, 2021 | Signed | Evan Justice | — | Colorado Rockies | Colorado Rockies signed LHP Evan Justice. |
| Jul 26, 2021 | Signed | Jack Anderson | — | Detroit Tigers | Detroit Tigers signed RHP Jack Anderson. |
| Jul 26, 2021 | Signed as free agent | Justin Wrobleski | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent LHP Justin Wrobleski to a minor league contract. |
| Jul 26, 2021 | Signed as free agent | Jairo Diaz | — | Chicago Cubs | Chicago Cubs signed free agent C Jairo Diaz to a minor league contract. |
| Jul 26, 2021 | Signed as free agent | Yenrri Rojas | — | Chicago Cubs | Chicago Cubs signed free agent RHP Yenrri Rojas to a minor league contract. |
| Jul 25, 2021 | Trade | T.J. Zeuch | Toronto Blue Jays | St. Louis Cardinals | Toronto Blue Jays traded RHP T.J. Zeuch to St. Louis Cardinals for cash. |
| Jul 25, 2021 | Signed | Luca Tresh | — | Kansas City Royals | Kansas City Royals signed C Luca Tresh. |
| Jul 25, 2021 | Signed as free agent | Dillan Shrum | — | Kansas City Royals | Kansas City Royals signed free agent 1B Dillan Shrum to a minor league contract. |
| Jul 25, 2021 | Signed as free agent | Parker Harm | — | Kansas City Royals | Kansas City Royals signed free agent LHP Parker Harm to a minor league contract. |
| Jul 25, 2021 | Signed as free agent | Leo Palacios | — | Kansas City Royals | Kansas City Royals signed free agent LHP Leo Palacios to a minor league contract. |
| Jul 25, 2021 | Signed as free agent | Jerad Eickhoff | — | New York Mets | New York Mets signed free agent RHP Jerad Eickhoff to a minor league contract. |
| Jul 25, 2021 | Signed | Zack Raabe | — | Milwaukee Brewers | Milwaukee Brewers signed 2B Zack Raabe. |
| Jul 25, 2021 | Signed | Logan Henderson | — | Milwaukee Brewers | Milwaukee Brewers signed RHP Logan Henderson. |
| Jul 25, 2021 | Signed | Ryan Sublette | — | Los Angeles Dodgers | Los Angeles Dodgers signed RHP Ryan Sublette. |
| Jul 25, 2021 | Signed | Gabe Emmett | — | Los Angeles Dodgers | Los Angeles Dodgers signed RHP Gabe Emmett. |
| Jul 24, 2021 | Trade | Mark Payton | Cincinnati Reds | New York Mets | Cincinnati Reds traded CF Mark Payton to New York Mets for cash. |
| Jul 24, 2021 | Signed | James Triantos | — | Chicago Cubs | Chicago Cubs signed 3B James Triantos. |
| Jul 24, 2021 | Signed | Erian Rodriguez | — | Chicago Cubs | Chicago Cubs signed RHP Erian Rodriguez. |
| Jul 24, 2021 | Signed | Frankie Scalzo Jr. | — | Chicago Cubs | Chicago Cubs signed RHP Frankie Scalzo Jr.. |
| Jul 24, 2021 | Signed | BJ Murray Jr. | — | Chicago Cubs | Chicago Cubs signed 3B BJ Murray Jr.. |
| Jul 24, 2021 | Signed | Zac Leigh | — | Chicago Cubs | Chicago Cubs signed RHP Zachary Leigh. |
| Jul 24, 2021 | Signed | Christian Olivo | — | Chicago Cubs | Chicago Cubs signed SS Christian Olivo. |
| Jul 24, 2021 | Signed | Elmer Rodríguez | — | Boston Red Sox | Boston Red Sox signed RHP Elmer Rodriguez-Cruz. |
| Jul 24, 2021 | Signed | Wyatt Olds | — | Boston Red Sox | Boston Red Sox signed RHP Wyatt Olds. |
| Jul 24, 2021 | Signed | Hunter Dobbins | — | Boston Red Sox | Boston Red Sox signed RHP Hunter Dobbins. |
| Jul 24, 2021 | Signed | Christopher Troye | — | Boston Red Sox | Boston Red Sox signed RHP Christopher Troye. |
| Jul 24, 2021 | Signed | Jacob Webb | — | Boston Red Sox | Boston Red Sox signed RHP Jacob Webb. |
| Jul 24, 2021 | Signed | Tyler Uberstine | — | Boston Red Sox | Boston Red Sox signed RHP Tyler Uberstine. |
| Jul 24, 2021 | Signed | Daniel McElveny | — | Boston Red Sox | Boston Red Sox signed SS Daniel McElveny. |
| Jul 24, 2021 | Signed | Tyler Miller | — | Boston Red Sox | Boston Red Sox signed 3B Tyler Miller. |
| Jul 24, 2021 | Signed | B.J. Vela | — | Boston Red Sox | Boston Red Sox signed 2B B.J. Vela. |
| Jul 24, 2021 | Signed | Phillip Sikes | — | Boston Red Sox | Boston Red Sox signed OF Phillip Sikes. |
| Jul 24, 2021 | Signed as free agent | Kier Meredith | — | Boston Red Sox | Boston Red Sox signed free agent OF Kier Meredith to a minor league contract. |
| Jul 24, 2021 | Signed as free agent | Jhonny Felix | — | Boston Red Sox | Boston Red Sox signed free agent RHP Jhonny Felix to a minor league contract. |
| Jul 24, 2021 | Signed as free agent | Jake Dahlberg | — | San Francisco Giants | San Francisco Giants signed free agent LHP Jake Dahlberg to a minor league contract. |
| Jul 24, 2021 | Signed as free agent | Seth Caddell | — | Cleveland Guardians | Cleveland Indians signed free agent C Seth Caddell to a minor league contract. |
| Jul 24, 2021 | Signed | Gavin Williams | — | Cleveland Guardians | Cleveland Indians signed RHP Gavin Williams. |
| Jul 24, 2021 | Signed | Doug Nikhazy | — | Cleveland Guardians | Cleveland Indians signed LHP Doug Nikhazy. |
| Jul 24, 2021 | Signed | Tommy Mace | — | Cleveland Guardians | Cleveland Indians signed RHP Tommy Mace. |
| Jul 24, 2021 | Signed | Jake Fox | — | Cleveland Guardians | Cleveland Indians signed SS Jake Fox. |
| Jul 24, 2021 | Signed | Aaron Davenport | — | Cleveland Guardians | Cleveland Indians signed RHP Aaron Davenport. |
| Jul 24, 2021 | Signed | Jack Leftwich | — | Cleveland Guardians | Cleveland Indians signed RHP Jack Leftwich. |
| Jul 24, 2021 | Signed | Ryan Webb | — | Cleveland Guardians | Cleveland Indians signed LHP Ryan Webb. |
| Jul 24, 2021 | Signed | Tanner Bibee | — | Cleveland Guardians | Cleveland Indians signed RHP Tanner Bibee. |
| Jul 24, 2021 | Signed | Rodney Boone | — | Cleveland Guardians | Cleveland Indians signed LHP Rodney Boone. |
| Jul 24, 2021 | Signed | Hunter Stanley | — | Cleveland Guardians | Cleveland Indians signed RHP Hunter Stanley. |
| Jul 24, 2021 | Signed | Will Dion | — | Cleveland Guardians | Cleveland Indians signed LHP Will Dion. |
| Jul 24, 2021 | Signed | Franco Aleman | — | Cleveland Guardians | Cleveland Indians signed RHP Franco Aleman. |
| Jul 24, 2021 | Signed | Connor Kokx | — | Cleveland Guardians | Cleveland Indians signed OF Connor Kokx. |
| Jul 24, 2021 | Signed | Davis Sharpe | — | Cleveland Guardians | Cleveland Indians signed RHP Davis Sharpe. |
| Jul 24, 2021 | Signed | Trenton Denholm | — | Cleveland Guardians | Cleveland Indians signed RHP Trenton Denholm. |
| Jul 24, 2021 | Signed | Alaska Abney | — | Cleveland Guardians | Cleveland Indians signed RHP Alaska Abney. |
| Jul 24, 2021 | Signed | Tyler Thornton | — | Cleveland Guardians | Cleveland Indians signed RHP Tyler Thornton. |
| Jul 24, 2021 | Signed | Reid Johnston | — | Cleveland Guardians | Cleveland Indians signed RHP Reid Johnston. |
| Jul 24, 2021 | Signed | Zach Pettway | — | Cleveland Guardians | Cleveland Indians signed RHP Zach Pettway. |
| Jul 24, 2021 | Signed | Tommy Ventimiglia | — | Cleveland Guardians | Cleveland Indians signed RHP Tommy Ventimiglia. |
| Jul 24, 2021 | Signed | Peyton Wilson | — | Kansas City Royals | Kansas City Royals signed 2B Peyton Wilson. |
| Jul 24, 2021 | Signed | Eric Cerantola | — | Kansas City Royals | Kansas City Royals signed RHP Eric Cerantola. |
| Jul 24, 2021 | Released | Kyle Crick | — | Pittsburgh Pirates | Pittsburgh Pirates released RHP Kyle Crick. |
| Jul 24, 2021 | Signed as free agent | Victor Pena | — | Kansas City Royals | Kansas City Royals signed free agent LHP Victor Pena to a minor league contract. |
| Jul 24, 2021 | Signed | Wes Kath | — | Chicago White Sox | Chicago White Sox signed 3B Wes Kath. |
| Jul 24, 2021 | Signed | Sean Burke | — | Chicago White Sox | Chicago White Sox signed RHP Sean Burke. |
| Jul 24, 2021 | Signed | Tanner McDougal | — | Chicago White Sox | Chicago White Sox signed RHP Tanner McDougal. |
| Jul 24, 2021 | Signed as free agent | David Freitas | — | Tampa Bay Rays | Tampa Bay Rays signed free agent C David Freitas to a minor league contract. |
| Jul 24, 2021 | Signed | Channy Ortiz | — | Arizona Diamondbacks | Arizona Diamondbacks signed SS Channy Ortiz. |
| Jul 24, 2021 | Signed | Tim Tawa | — | Arizona Diamondbacks | Arizona Diamondbacks signed 2B Tim Tawa. |
| Jul 24, 2021 | Signed | Matt Rudick | — | New York Mets | New York Mets signed OF Matt Rudick. |
| Jul 24, 2021 | Signed | Mo Hanley | — | Los Angeles Angels | Los Angeles Angels signed LHP Mo Hanley. |
| Jul 24, 2021 | Signed as free agent | Ronny Ramirez | — | Boston Red Sox | Boston Red Sox signed free agent OF Ronny Ramirez to a minor league contract. |
| Jul 24, 2021 | Signed | Connor Pavolony | — | Baltimore Orioles | Baltimore Orioles signed C Connor Pavolony. |
| Jul 24, 2021 | Signed | Collin Burns | — | Baltimore Orioles | Baltimore Orioles signed SS Collin Burns. |
| Jul 24, 2021 | Signed as free agent | Kyler Castillo | — | Miami Marlins | Miami Marlins signed free agent RF Kyler Castillo to a minor league contract. |
| Jul 24, 2021 | Signed as free agent | Paul McIntosh | — | Miami Marlins | Miami Marlins signed free agent C Paul McIntosh to a minor league contract. |
| Jul 24, 2021 | Signed | Alec Willis | — | St. Louis Cardinals | St. Louis Cardinals signed RHP Alec Willis. |
| Jul 24, 2021 | Signed as free agent | Brenden Heiss | — | San Diego Padres | San Diego Padres signed free agent RHP Brenden Heiss to a minor league contract. |
| Jul 24, 2021 | Signed | Brandon White | — | Miami Marlins | Miami Marlins signed RHP Brandon White. |
| Jul 23, 2021 | Signed | Mike Rothenberg | — | Detroit Tigers | Detroit Tigers signed C Mike Rothenberg. |
| Jul 23, 2021 | Signed | Izaac Pacheco | — | Detroit Tigers | Detroit Tigers signed SS Izaac Pacheco. |
| Jul 23, 2021 | Signed | Jackson Jobe | — | Detroit Tigers | Detroit Tigers signed RHP Jackson Jobe. |
| Jul 23, 2021 | Signed | Creed Willems | — | Baltimore Orioles | Baltimore Orioles signed C Creed Willems. |
| Jul 23, 2021 | Signed | Ryan Higgins | — | Baltimore Orioles | Baltimore Orioles signed 3B Ryan Higgins. |
| Jul 23, 2021 | Signed | Billy Cook | — | Baltimore Orioles | Baltimore Orioles signed OF Billy Cook. |
| Jul 23, 2021 | Signed | Justin Armbruester | — | Baltimore Orioles | Baltimore Orioles signed RHP Justin Armbruester. |
| Jul 23, 2021 | Signed | Reed Trimble | — | Baltimore Orioles | Baltimore Orioles signed OF Reed Trimble. |
| Jul 23, 2021 | Signed | Carlos Tavera | — | Baltimore Orioles | Baltimore Orioles signed RHP Carlos Tavera. |
| Jul 23, 2021 | Signed | Jacob Teter | — | Baltimore Orioles | Baltimore Orioles signed 1B Jacob Teter. |
| Jul 23, 2021 | Signed | Keagan Gillies | — | Baltimore Orioles | Baltimore Orioles signed RHP Keagan Gillies. |
| Jul 23, 2021 | Signed | Conor Grady | — | Baltimore Orioles | Baltimore Orioles signed RHP Conor Grady. |
| Jul 23, 2021 | Signed | Peter Van Loon | — | Baltimore Orioles | Baltimore Orioles signed RHP Peter Van Loon. |
| Jul 23, 2021 | Signed | Ryan Long | — | Baltimore Orioles | Baltimore Orioles signed RHP Ryan Long. |
| Jul 23, 2021 | Signed | Alex Pham | — | Baltimore Orioles | Baltimore Orioles signed RHP Alex Pham. |
| Jul 23, 2021 | Trade | Matthew Dyer | New York Mets | Tampa Bay Rays | Tampa Bay Rays traded LHP Rich Hill to New York Mets for RHP Tommy Hunter and C Matt Dyer. |
| Jul 23, 2021 | Released | José De León | — | Cincinnati Reds | Cincinnati Reds released RHP Jose De Leon. |
| Jul 23, 2021 | Signed as free agent | Gerson Bautista | — | San Francisco Giants | San Francisco Giants signed free agent RHP Gerson Bautista to a minor league contract. |
| Jul 23, 2021 | Signed | Justyn-Henry Malloy | — | Atlanta Braves | Atlanta Braves signed 3B Justyn-Henry Malloy. |
| Jul 23, 2021 | Signed as free agent | J.J. Niekro | — | Atlanta Braves | Atlanta Braves signed free agent RHP J.J. Niekro to a minor league contract. |
| Jul 23, 2021 | Signed as free agent | Anderson De Los Santos | — | Atlanta Braves | Atlanta Braves signed free agent SS Anderson De Los Santos to a minor league contract. |
| Jul 23, 2021 | Signed | Ryan Cusick | — | Atlanta Braves | Atlanta Braves signed RHP Ryan Cusick. |
| Jul 23, 2021 | Signed | Cal Conley | — | Atlanta Braves | Atlanta Braves signed SS Cal Conley. |
| Jul 23, 2021 | Signed | Luke Waddell | — | Atlanta Braves | Atlanta Braves signed SS Luke Waddell. |
| Jul 23, 2021 | Signed | AJ Smith-Shawver | — | Atlanta Braves | Atlanta Braves signed RHP AJ Smith-Shawver. |
| Jul 23, 2021 | Signed | Tyler Collins | — | Atlanta Braves | Atlanta Braves signed OF Tyler Collins. |
| Jul 23, 2021 | Signed | Adam Shoemaker | — | Atlanta Braves | Atlanta Braves signed LHP Adam Shoemaker. |
| Jul 23, 2021 | Signed | Adam Zebrowski | — | Atlanta Braves | Atlanta Braves signed C Adam Zebrowski. |
| Jul 23, 2021 | Signed | Caleb Durbin | — | Atlanta Braves | Atlanta Braves signed SS Caleb Durbin. |
| Jul 23, 2021 | Signed | Kris Anglin | — | Atlanta Braves | Atlanta Braves signed LHP Kris Anglin. |
| Jul 23, 2021 | Signed | Samuel Strickland | — | Atlanta Braves | Atlanta Braves signed LHP Samuel Strickland. |
| Jul 23, 2021 | Signed | Tyler Tolve | — | Atlanta Braves | Atlanta Braves signed C Tyler Tolve. |
| Jul 23, 2021 | Signed | Austin Smith | — | Atlanta Braves | Atlanta Braves signed RHP Austin Smith. |
| Jul 23, 2021 | Signed | Matt Mikulski | — | San Francisco Giants | San Francisco Giants signed LHP Matt Mikulski. |
| Jul 23, 2021 | Signed | Mason Black | — | San Francisco Giants | San Francisco Giants signed RHP Mason Black. |
| Jul 23, 2021 | Signed | Will Bednar | — | San Francisco Giants | San Francisco Giants signed RHP Will Bednar. |
| Jul 23, 2021 | Signed | Seth Lonsway | — | San Francisco Giants | San Francisco Giants signed LHP Seth Lonsway. |
| Jul 23, 2021 | Signed | Rohan Handa | — | San Francisco Giants | San Francisco Giants signed LHP Rohan Handa. |
| Jul 23, 2021 | Signed | Mat Olsen | — | San Francisco Giants | San Francisco Giants signed RHP Mat Olsen. |
| Jul 23, 2021 | Signed | Vaun Brown | — | San Francisco Giants | San Francisco Giants signed OF Vaun Brown. |
| Jul 23, 2021 | Signed | Landen Roupp | — | San Francisco Giants | San Francisco Giants signed RHP Landen Roupp. |
| Jul 23, 2021 | Signed | Nick Sinacola | — | San Francisco Giants | San Francisco Giants signed RHP Nick Sinacola. |
| Jul 23, 2021 | Signed | Ian Villers | — | San Francisco Giants | San Francisco Giants signed RHP Ian Villers. |
| Jul 23, 2021 | Signed | Tyler Myrick | — | San Francisco Giants | San Francisco Giants signed RHP Tyler Myrick. |
| Jul 23, 2021 | Signed | Hunter Dula | — | San Francisco Giants | San Francisco Giants signed RHP Hunter Dula. |
| Jul 23, 2021 | Signed | Jared Dupere | — | San Francisco Giants | San Francisco Giants signed OF Jared Dupere. |
| Jul 23, 2021 | Signed | Brett Standlee | — | San Francisco Giants | San Francisco Giants signed RHP Brett Standlee. |
| Jul 23, 2021 | Signed | Irvin Murr III | — | San Francisco Giants | San Francisco Giants signed 3B Irvin Murr III. |
| Jul 23, 2021 | Signed | Evan Gates | — | San Francisco Giants | San Francisco Giants signed RHP Evan Gates. |
| Jul 23, 2021 | Signed as free agent | Max Wright | — | San Francisco Giants | San Francisco Giants signed free agent C Max Wright to a minor league contract. |
| Jul 23, 2021 | Signed as free agent | Konner Piotto | — | Texas Rangers | Texas Rangers signed free agent C Konner Piotto to a minor league contract. |
| Jul 23, 2021 | Signed as free agent | Raul Mendoza | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Raul Mendoza to a minor league contract. |
| Jul 23, 2021 | Signed as free agent | Darlin Lora | — | Milwaukee Brewers | Milwaukee Brewers signed free agent C Darlin Lora to a minor league contract. |
| Jul 23, 2021 | Signed | Adrian Del Castillo | — | Arizona Diamondbacks | Arizona Diamondbacks signed C Adrian Del Castillo. |
| Jul 23, 2021 | Signed | Shane Muntz | — | Arizona Diamondbacks | Arizona Diamondbacks signed C Shane Muntz. |
| Jul 23, 2021 | Signed | Austin Schultz | — | Detroit Tigers | Detroit Tigers signed OF Austin Schultz. |
| Jul 23, 2021 | Signed | Chris Meyers | — | Detroit Tigers | Detroit Tigers signed 3B Chris Meyers. |
| Jul 23, 2021 | Signed | Mike Vasil | — | New York Mets | New York Mets signed RHP Mike Vasil. |
| Jul 23, 2021 | Signed | Mason Erla | — | Los Angeles Angels | Los Angeles Angels signed RHP Mason Erla. |
| Jul 23, 2021 | Signed as free agent | Damon Keith | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent OF Damon Keith to a minor league contract. |
| Jul 23, 2021 | Signed as free agent | Parker Scott | — | Philadelphia Phillies | Philadelphia Phillies signed free agent LHP Parker Scott to a minor league contract. |
| Jul 23, 2021 | Signed as free agent | Irving Igualas | — | Milwaukee Brewers | Milwaukee Brewers signed free agent OF Irving Igualas to a minor league contract. |
| Jul 23, 2021 | Signed | Joe Mack | — | Miami Marlins | Miami Marlins signed C Joe Mack. |
| Jul 23, 2021 | Signed | Emmet Sheehan | — | Los Angeles Dodgers | Los Angeles Dodgers signed RHP Emmet Sheehan. |
| Jul 23, 2021 | Signed | Antonio Knowles | — | Los Angeles Dodgers | Los Angeles Dodgers signed RHP Antonio Knowles. |
| Jul 23, 2021 | Signed | Nick Nastrini | — | Los Angeles Dodgers | Los Angeles Dodgers signed RHP Nick Nastrini. |
| Jul 23, 2021 | Signed | Russell Smith | — | Milwaukee Brewers | Milwaukee Brewers signed LHP Russell Smith. |
| Jul 23, 2021 | Signed | Daylen Lile | — | Washington Nationals | Washington Nationals signed OF Daylen Lile. |
| Jul 23, 2021 | Signed as free agent | Kay-Lan Nicasia | — | Milwaukee Brewers | Milwaukee Brewers signed free agent SS Kaylan Nicasia to a minor league contract. |
| Jul 23, 2021 | Signed | Ryne Moore | — | Milwaukee Brewers | Milwaukee Brewers signed RHP Ryne Moore. |
| Jul 23, 2021 | Signed | Ronan Kopp | — | Los Angeles Dodgers | Los Angeles Dodgers signed LHP Ronan Kopp. |
| Jul 23, 2021 | Signed | Ben Harris | — | Los Angeles Dodgers | Los Angeles Dodgers signed LHP Ben Harris. |
| Jul 23, 2021 | Signed as free agent | Jonathan Edwards | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Jonathan Edwards to a minor league contract. |
| Jul 23, 2021 | Signed | Brannon Jordan | — | Milwaukee Brewers | Milwaukee Brewers signed RHP Brannon Jordan. |
| Jul 23, 2021 | Signed | RJ Petit | — | Detroit Tigers | Detroit Tigers signed RHP RJ Petit. |
| Jul 23, 2021 | Signed | Ben Casparius | — | Los Angeles Dodgers | Los Angeles Dodgers signed RHP Ben Casparius. |
| Jul 23, 2021 | Signed | Mikey Perez | — | Minnesota Twins | Minnesota Twins signed SS Mikey Perez. |
| Jul 23, 2021 | Signed | Dillon Tatum | — | Minnesota Twins | Minnesota Twins signed C Dillon Tatum. |
| Jul 23, 2021 | Signed | Mike Paredes | — | Minnesota Twins | Minnesota Twins signed RHP Mike Paredes. |
| Jul 23, 2021 | Signed | Johnathan Lavallee | — | Minnesota Twins | Minnesota Twins signed RHP Johnathan Lavallee. |
| Jul 23, 2021 | Signed as free agent | Madison Jeffrey | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Madison Jeffrey to a minor league contract. |
| Jul 23, 2021 | Signed as free agent | Gaige Howard | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent OF Gaige Howard to a minor league contract. |
| Jul 23, 2021 | Signed as free agent | Francisco Mateo | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Francisco Mateo to a minor league contract. |
| Jul 22, 2021 | Signed as free agent | Wade Stauss | — | St. Louis Cardinals | St. Louis Cardinals signed free agent C Wade Stauss to a minor league contract. |
| Jul 22, 2021 | Signed | Andre Granillo | — | St. Louis Cardinals | St. Louis Cardinals signed RHP Andre Granillo. |
| Jul 22, 2021 | Signed | Bubba Chandler | — | Pittsburgh Pirates | Pittsburgh Pirates signed RHP Bubba Chandler. |
| Jul 22, 2021 | Signed as free agent | Ryan Loutos | — | St. Louis Cardinals | St. Louis Cardinals signed free agent RHP Ryan Loutos to a minor league contract. |
| Jul 22, 2021 | Signed as free agent | Noah Mendlinger | — | St. Louis Cardinals | St. Louis Cardinals signed free agent 3B Noah Mendlinger to a minor league contract. |
| Jul 22, 2021 | Signed as free agent | Bryan Pope | — | St. Louis Cardinals | St. Louis Cardinals signed free agent RHP Bryan Pope to a minor league contract. |
| Jul 22, 2021 | Signed | Ryan Holgate | — | St. Louis Cardinals | St. Louis Cardinals signed OF Ryan Holgate. |
| Jul 22, 2021 | Signed | Austin Love | — | St. Louis Cardinals | St. Louis Cardinals signed RHP Austin Love. |
| Jul 22, 2021 | Signed | Hayes Heinecke | — | St. Louis Cardinals | St. Louis Cardinals signed LHP Hayes Heinecke. |
| Jul 22, 2021 | Signed | Jaden Hill | — | Colorado Rockies | Colorado Rockies signed RHP Jaden Hill. |
| Jul 22, 2021 | Signed as free agent | Dustin Garneau | — | Colorado Rockies | Colorado Rockies signed free agent C Dustin Garneau to a minor league contract. |
| Jul 22, 2021 | Signed | Mack Chambers | — | St. Louis Cardinals | St. Louis Cardinals signed SS Mack Chambers. |
| Jul 22, 2021 | Signed | Chris Gerard | — | St. Louis Cardinals | St. Louis Cardinals signed LHP Chris Gerard. |
| Jul 22, 2021 | Signed | Tyler McDonough | — | Boston Red Sox | Boston Red Sox signed 2B Tyler McDonough. |
| Jul 22, 2021 | Signed | Marcelo Mayer | — | Boston Red Sox | Boston Red Sox signed SS Marcelo Mayer. |
| Jul 22, 2021 | Trade | Drew Strotman | Tampa Bay Rays | Minnesota Twins | Tampa Bay Rays traded RHP Drew Strotman and RHP Joe Ryan to Minnesota Twins for DH Nelson Cruz and RHP Calvin Faucher. |
| Jul 22, 2021 | Signed as free agent | Jorge Geraldo | — | Houston Astros | Houston Astros signed free agent RHP Jorge Geraldo to a minor league contract. |
| Jul 22, 2021 | Signed | Noah Miller | — | Minnesota Twins | Minnesota Twins signed SS Noah Miller. |
| Jul 22, 2021 | Signed as free agent | Brayan Oropeza | — | Milwaukee Brewers | Milwaukee Brewers signed free agent C Brayan Oropeza to a minor league contract. |
| Jul 22, 2021 | Signed as free agent | Carlos Navas | — | Washington Nationals | Washington Nationals signed free agent RHP Carlos Navas to a minor league contract. |
| Jul 22, 2021 | Signed | Nate Lavender | — | New York Mets | New York Mets signed LHP Nathan Lavender. |
| Jul 22, 2021 | Signed | Mason Albright | — | Los Angeles Angels | Los Angeles Angels signed LHP Mason Albright. |
| Jul 22, 2021 | Signed | Ethan Murray | — | Milwaukee Brewers | Milwaukee Brewers signed SS Ethan Murray. |
| Jul 22, 2021 | Signed | Wes Clarke | — | Milwaukee Brewers | Milwaukee Brewers signed C Wes Clarke. |
| Jul 22, 2021 | Signed | Jesse Bergin | — | Miami Marlins | Miami Marlins signed RHP Jesse Bergin. |
| Jul 22, 2021 | Signed as free agent | Jamison Hill | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Jamison Hill to a minor league contract. |
| Jul 22, 2021 | Signed | Jordan McCants | — | Miami Marlins | Miami Marlins signed SS Jordan McCants. |
| Jul 22, 2021 | Signed | Dylan Heid | — | Baltimore Orioles | Baltimore Orioles signed RHP Dylan Heid. |
| Jul 22, 2021 | Signed | Patrick Winkel | — | Minnesota Twins | Minnesota Twins signed C Patrick Winkel. |
| Jul 22, 2021 | Signed | Steve Hajjar | — | Minnesota Twins | Minnesota Twins signed LHP Steve Hajjar. |
| Jul 22, 2021 | Signed | Brock Selvidge | — | New York Yankees | New York Yankees signed LHP Brock Selvidge. |
| Jul 22, 2021 | Signed | Michael Morales | — | Seattle Mariners | Seattle Mariners signed RHP Michael Morales. |
| Jul 22, 2021 | Signed as free agent | Grant Hartwig | — | New York Mets | New York Mets signed free agent RHP Grant Hartwig to a minor league contract. |
| Jul 22, 2021 | Signed | Mason Auer | — | Tampa Bay Rays | Tampa Bay Rays signed OF Mason Auer. |
| Jul 21, 2021 | Signed | Ian Moller | — | Texas Rangers | Texas Rangers signed C Ian Moller. |
| Jul 21, 2021 | Signed | Cam Cauley | — | Texas Rangers | Texas Rangers signed SS Cameron Cauley. |
| Jul 21, 2021 | Released | Nomar Mazara | — | Detroit Tigers | Detroit Tigers released RF Nomar Mazara. |
| Jul 21, 2021 | Trade | Joel Payamps | Toronto Blue Jays | Kansas City Royals | Toronto Blue Jays traded RHP Joel Payamps to Kansas City Royals for cash. |
| Jul 21, 2021 | Signed | Drew Swift | — | Athletics | Oakland Athletics signed SS Drew Swift. |
| Jul 21, 2021 | Signed | Mason Miller | — | Athletics | Oakland Athletics signed RHP Mason Miller. |
| Jul 21, 2021 | Signed | Max Muncy | — | Athletics | Oakland Athletics signed SS Max Muncy. |
| Jul 21, 2021 | Signed | Grant Holman | — | Athletics | Oakland Athletics signed RHP Grant Holman. |
| Jul 21, 2021 | Signed | Brett Harris | — | Athletics | Oakland Athletics signed 3B Brett Harris. |
| Jul 21, 2021 | Signed | Shane McGuire | — | Athletics | Oakland Athletics signed C Shane McGuire. |
| Jul 21, 2021 | Signed | Eduardo Rivera | — | Athletics | Oakland Athletics signed LHP Eduardo Rivera. |
| Jul 21, 2021 | Signed | Mitch Myers | — | Athletics | Oakland Athletics signed RHP Mitch Myers. |
| Jul 21, 2021 | Signed | Luke Anderson | — | Athletics | Oakland Athletics signed RHP Luke Anderson. |
| Jul 21, 2021 | Signed | Colton Johnson | — | Athletics | Oakland Athletics signed LHP Colton Johnson. |
| Jul 21, 2021 | Signed | Jack Winkler | — | Athletics | Oakland Athletics signed SS Jack WInkler. |
| Jul 21, 2021 | Signed | Aaron Holiday | — | Athletics | Oakland Athletics signed RHP Aaron Holiday. |
| Jul 21, 2021 | Signed | Jonny Butler | — | Athletics | Oakland Athletics signed OF Jonny Butler. |
| Jul 21, 2021 | Signed | Kyle Virbitsky | — | Athletics | Oakland Athletics signed RHP Kyle Virbitsky. |
| Jul 21, 2021 | Signed | Hunter Breault | — | Athletics | Oakland Athletics signed RHP Hunter Breault. |
| Jul 21, 2021 | Signed | Mariano Ricciardi | — | Athletics | Oakland Athletics signed 2B Mariano Ricciardi. |
| Jul 21, 2021 | Signed | Blake Beers | — | Athletics | Oakland Athletics signed RHP Blake Beers. |
| Jul 21, 2021 | Signed as free agent | Nick Brueser | — | Athletics | Oakland Athletics signed free agent 1B Nick Brueser to a minor league contract. |
| Jul 21, 2021 | Signed as free agent | Jack Owen | — | Athletics | Oakland Athletics signed free agent LHP Jack Owen to a minor league contract. |
| Jul 21, 2021 | Signed | Hayden Juenger | — | Toronto Blue Jays | Toronto Blue Jays signed RHP Hayden Juenger. |
| Jul 21, 2021 | Signed | Ricky Tiedemann | — | Toronto Blue Jays | Toronto Blue Jays signed LHP Ricky Tiedemann. |
| Jul 21, 2021 | Signed | Chad Dallas | — | Toronto Blue Jays | Toronto Blue Jays signed RHP Chad Dallas. |
| Jul 21, 2021 | Signed | Irv Carter | — | Toronto Blue Jays | Toronto Blue Jays signed RHP Irv Carter. |
| Jul 21, 2021 | Signed | Jaden Rudd | — | Toronto Blue Jays | Toronto Blue Jays signed OF Jaden Rudd. |
| Jul 21, 2021 | Signed | Hunter Gregory | — | Toronto Blue Jays | Toronto Blue Jays signed RHP Hunter Gregory. |
| Jul 21, 2021 | Signed | Conor Larkin | — | Toronto Blue Jays | Toronto Blue Jays signed RHP Conor Larkin. |
| Jul 21, 2021 | Signed | Connor Cooke | — | Toronto Blue Jays | Toronto Blue Jays signed RHP Connor Cooke. |
| Jul 21, 2021 | Signed | Trenton Wallace | — | Toronto Blue Jays | Toronto Blue Jays signed LHP Trenton Wallace. |
| Jul 21, 2021 | Signed | Riley Tirotta | — | Toronto Blue Jays | Toronto Blue Jays signed 3B Riley Tirotta. |
| Jul 21, 2021 | Signed | Matt Svanson | — | Toronto Blue Jays | Toronto Blue Jays signed RHP Matt Svanson. |
| Jul 21, 2021 | Signed | Garrett Spain | — | Toronto Blue Jays | Toronto Blue Jays signed OF Garrett Spain. |
| Jul 21, 2021 | Signed | Dayton Dooney | — | Kansas City Royals | Kansas City Royals signed 2B Dayton Dooney. |
| Jul 21, 2021 | Signed | Jimmy Burnette | — | Toronto Blue Jays | Toronto Blue Jays signed LHP Jimmy Burnette. |
| Jul 21, 2021 | Signed | Juan Gonzalez | — | Toronto Blue Jays | Toronto Blue Jays signed C Juan Gonzalez. |
| Jul 21, 2021 | Signed as free agent | Justin Kelly | — | Toronto Blue Jays | Toronto Blue Jays signed free agent RHP Justin Kelly to a minor league contract. |
| Jul 21, 2021 | Signed as free agent | Harry Rutkowski | — | Toronto Blue Jays | Toronto Blue Jays signed free agent LHP Harry Rutkowski to a minor league contract. |
| Jul 21, 2021 | Trade | Carlos Rincon | Los Angeles Dodgers | New York Mets | New York Mets traded LF Billy McKinney to Los Angeles Dodgers for RF Carlos Rincon. |
| Jul 21, 2021 | Signed | Carter Jensen | — | Kansas City Royals | Kansas City Royals signed C Carter Jensen. |
| Jul 21, 2021 | Signed | Brennon McNair | — | Kansas City Royals | Kansas City Royals signed SS Brennon McNair. |
| Jul 21, 2021 | Signed | Carlos Lomeli | — | Pittsburgh Pirates | Pittsburgh Pirates signed RHP Carlos Lomeli. |
| Jul 21, 2021 | Signed | Tyler Whitaker | — | Houston Astros | Houston Astros signed OF Tyler Whitaker. |
| Jul 21, 2021 | Signed | Drew Irvine | — | Pittsburgh Pirates | Pittsburgh Pirates signed RHP Drew Irvine. |
| Jul 21, 2021 | Signed as free agent | Elvis Novas | — | Kansas City Royals | Kansas City Royals signed free agent RHP Elvis Novas to a minor league contract. |
| Jul 21, 2021 | Signed as free agent | Luis Castaneda | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent IF Luis Castaneda to a minor league contract. |
| Jul 21, 2021 | Signed | Ben Malgeri | — | Detroit Tigers | Detroit Tigers signed OF Ben Malgeri. |
| Jul 21, 2021 | Signed | J.D. McLaughlin | — | Detroit Tigers | Detroit Tigers signed CF J.D. McLaughlin. |
| Jul 21, 2021 | Signed | Blake Holub | — | Detroit Tigers | Detroit Tigers signed RHP Blake Holub. |
| Jul 21, 2021 | Signed as free agent | Alex McKenney | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RHP Alex McKenney to a minor league contract. |
| Jul 21, 2021 | Signed | Bryant Salgado | — | Houston Astros | Houston Astros signed RHP Bryant Salgado. |
| Jul 21, 2021 | Signed | Adrian Chaidez | — | Houston Astros | Houston Astros signed RHP Adrian Chaidez. |
| Jul 21, 2021 | Signed as free agent | Jaxon Hallmark | — | Houston Astros | Houston Astros signed free agent OF Jaxon Hallmark to a minor league contract. |
| Jul 21, 2021 | Signed | Colby Smelley | — | Chicago White Sox | Chicago White Sox signed C Colby Smelley. |
| Jul 21, 2021 | Signed | Noah Owen | — | Chicago White Sox | Chicago White Sox signed RHP Noah Owen. |
| Jul 21, 2021 | Signed | Brooks Gosswein | — | Chicago White Sox | Chicago White Sox signed LHP Brooks Gosswein. |
| Jul 21, 2021 | Signed | Christian Edwards | — | Chicago White Sox | Chicago White Sox signed RHP Christian Edwards. |
| Jul 21, 2021 | Signed | Johnny Ray | — | Chicago White Sox | Chicago White Sox signed RHP Johnny Ray. |
| Jul 21, 2021 | Signed | Cameron Butler | — | Chicago White Sox | Chicago White Sox signed OF Cameron Butler. |
| Jul 21, 2021 | Signed | Terrell Tatum | — | Chicago White Sox | Chicago White Sox signed OF Terrell Tatum. |
| Jul 21, 2021 | Signed | Jayson Gonzalez | — | Chicago White Sox | Chicago White Sox signed 3B Jayson Gonzalez. |
| Jul 21, 2021 | Signed | Adam Hackenberg | — | Chicago White Sox | Chicago White Sox signed C Adam Hackenberg. |
| Jul 21, 2021 | Signed | Shawn Goosenberg | — | Chicago White Sox | Chicago White Sox signed SS Shawn Goosenberg. |
| Jul 21, 2021 | Signed | Haylen Green | — | Chicago White Sox | Chicago White Sox signed LHP Haylen Green. |
| Jul 21, 2021 | Signed as free agent | Cameron Leonard | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP Cameron Leonard to a minor league contract. |
| Jul 21, 2021 | Signed as free agent | Kyle Whitten | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP Kyle Whitten to a minor league contract. |
| Jul 21, 2021 | Signed | Joey Loperfido | — | Houston Astros | Houston Astros signed OF Joey Loperfido. |
| Jul 21, 2021 | Signed | Kevin Kendall | — | New York Mets | New York Mets signed SS Kevin Kendall. |
| Jul 21, 2021 | Signed | Jack-Thomas Wold | — | New York Mets | New York Mets signed OF Jack-Thomas Wold. |
| Jul 21, 2021 | Signed | Nick Zwack | — | New York Mets | New York Mets signed LHP Nick Zwack. |
| Jul 21, 2021 | Signed as free agent | Houston Harding | — | Los Angeles Angels | Los Angeles Angels signed free agent LHP Houston Harding to a minor league contract. |
| Jul 21, 2021 | Signed | Alex Ayala Jr. | — | Tampa Bay Rays | Tampa Bay Rays signed LHP Alex Ayala Jr.. |
| Jul 21, 2021 | Signed | Braxton Fulford | — | Colorado Rockies | Colorado Rockies signed C Braxton Fulford. |
| Jul 21, 2021 | Signed | Hunter Goodman | — | Colorado Rockies | Colorado Rockies signed C Hunter Goodman. |
| Jul 21, 2021 | Signed | Benny Montgomery | — | Colorado Rockies | Colorado Rockies signed OF Benny Montgomery. |
| Jul 21, 2021 | Signed | Conor Dryer | — | Tampa Bay Rays | Tampa Bay Rays signed RHP Conor Dryer. |
| Jul 21, 2021 | Signed | Austin Vernon | — | Tampa Bay Rays | Tampa Bay Rays signed RHP Austin Vernon. |
| Jul 21, 2021 | Signed | Matt Russell | — | Philadelphia Phillies | Philadelphia Phillies signed RHP Matt Russell. |
| Jul 21, 2021 | Signed as free agent | Ben Miller | — | San Diego Padres | San Diego Padres signed free agent LHP Ben Miller to a minor league contract. |
| Jul 21, 2021 | Signed as free agent | Tyler Santana | — | Chicago Cubs | Chicago Cubs signed free agent RHP Tyler Santana to a minor league contract. |
| Jul 21, 2021 | Signed | Kyler Fedko | — | Minnesota Twins | Minnesota Twins signed OF Kyler Fedko. |
| Jul 21, 2021 | Signed | McCade Brown | — | Colorado Rockies | Colorado Rockies signed RHP McCade Brown. |
| Jul 21, 2021 | Signed | Joe Rock | — | Colorado Rockies | Colorado Rockies signed LHP Joe Rock. |
| Jul 21, 2021 | Signed | Maddux Bruns | — | Los Angeles Dodgers | Los Angeles Dodgers signed LHP Maddux Bruns. |
| Jul 21, 2021 | Signed | Jake Rucker | — | Minnesota Twins | Minnesota Twins signed 3B Jake Rucker. |
| Jul 21, 2021 | Signed | Christian Encarnacion-Strand | — | Minnesota Twins | Minnesota Twins signed 3B Christian Encarnacion-Strand. |
| Jul 21, 2021 | Signed | Bryce McGowan | — | Colorado Rockies | Colorado Rockies signed RHP Bryce McGowan. |
| Jul 21, 2021 | Signed | Bob Seymour | — | Tampa Bay Rays | Tampa Bay Rays signed 1B Bobby Seymour. |
| Jul 21, 2021 | Signed | Sean Mullen | — | Tampa Bay Rays | Tampa Bay Rays signed RHP Sean Mullen. |
| Jul 21, 2021 | Signed | Kobe Robinson | — | San Diego Padres | San Diego Padres signed RHP Kobe Robinson. |
| Jul 21, 2021 | Signed | Cade Povich | — | Minnesota Twins | Minnesota Twins signed LHP Cade Povich. |
| Jul 21, 2021 | Signed | David Festa | — | Minnesota Twins | Minnesota Twins signed RHP David Festa. |
| Jul 21, 2021 | Signed | Jonny Cuevas | — | Tampa Bay Rays | Tampa Bay Rays signed RHP Jonny Cuevas. |
| Jul 21, 2021 | Signed | Kamron Fields | — | Tampa Bay Rays | Tampa Bay Rays signed RHP Kamron Fields. |
| Jul 21, 2021 | Signed | Ernie Yake | — | Minnesota Twins | Minnesota Twins signed SS Ernie Yake. |
| Jul 21, 2021 | Signed | Jack Neely | — | New York Yankees | New York Yankees signed RHP Jack Neely. |
| Jul 21, 2021 | Signed | Pierson Ohl | — | Minnesota Twins | Minnesota Twins signed RHP Pierson Ohl. |
| Jul 21, 2021 | Signed | Jaylen Nowlin | — | Minnesota Twins | Minnesota Twins signed LHP Jaylen Nowlin. |
| Jul 21, 2021 | Signed | Travis Adams | — | Minnesota Twins | Minnesota Twins signed RHP Travis Adams. |
| Jul 21, 2021 | Signed | Dylan Neuse | — | Minnesota Twins | Minnesota Twins signed 2B Dylan Neuse. |
| Jul 21, 2021 | Signed as free agent | Cam Cowan | — | Cincinnati Reds | Cincinnati Reds signed free agent RHP Cam Cowan to a minor league contract. |
| Jul 21, 2021 | Signed | Robby Ahlstrom | — | New York Yankees | New York Yankees signed LHP Robert Ahlstrom. |
| Jul 21, 2021 | Signed as free agent | Jamal O'Guinn | — | Cincinnati Reds | Cincinnati Reds signed free agent OF Jamal O'Guinn to a minor league contract. |
| Jul 21, 2021 | Signed | Antonio Menendez | — | Tampa Bay Rays | Tampa Bay Rays signed RHP Antonio Menendez. |
| Jul 20, 2021 | Signed | Anthony Solometo | — | Pittsburgh Pirates | Pittsburgh Pirates signed LHP Anthony Solometo. |
| Jul 20, 2021 | Signed | Sal Frelick | — | Milwaukee Brewers | Milwaukee Brewers signed OF Sal Frelick. |
| Jul 20, 2021 | Signed | Tyler Black | — | Milwaukee Brewers | Milwaukee Brewers signed 2B Tyler Black. |
| Jul 20, 2021 | Signed | Alex Binelas | — | Milwaukee Brewers | Milwaukee Brewers signed 3B Alex Binelas. |
| Jul 20, 2021 | Signed as free agent | Matt Tomshaw | — | Washington Nationals | Washington Nationals signed free agent LHP Matt Tomshaw to a minor league contract. |
| Jul 20, 2021 | Signed as free agent | Matt Pobereyko | — | Miami Marlins | Miami Marlins signed free agent RHP Matt Pobereyko to a minor league contract. |
| Jul 20, 2021 | Signed | Colson Montgomery | — | Chicago White Sox | Chicago White Sox signed SS Colson Montgomery. |
| Jul 20, 2021 | Signed as free agent | Nick Dombkowski | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent LHP Nick Dombkowski to a minor league contract. |
| Jul 20, 2021 | Signed | Owen Sharts | — | Pittsburgh Pirates | Pittsburgh Pirates signed RHP Owen Sharts. |
| Jul 20, 2021 | Signed | Jack Carey | — | Pittsburgh Pirates | Pittsburgh Pirates signed RHP Jack Carey. |
| Jul 20, 2021 | Signed | Spencer Packard | — | Seattle Mariners | Seattle Mariners signed OF Spencer Packard. |
| Jul 20, 2021 | Signed | Cole Barr | — | Seattle Mariners | Seattle Mariners signed 3B Cole Barr. |
| Jul 20, 2021 | Signed | Tyler Samaniego | — | Pittsburgh Pirates | Pittsburgh Pirates signed LHP Tyler Samaniego. |
| Jul 20, 2021 | Signed | Bryce Miller | — | Seattle Mariners | Seattle Mariners signed RHP Bryce Miller. |
| Jul 20, 2021 | Signed | Andy Thomas | — | Seattle Mariners | Seattle Mariners signed C Andy Thomas. |
| Jul 20, 2021 | Signed | Bryan Woo | — | Seattle Mariners | Seattle Mariners signed RHP Bryan Woo. |
| Jul 20, 2021 | Signed | Colin Davis | — | Seattle Mariners | Seattle Mariners signed OF Colin Davis. |
| Jul 20, 2021 | Signed | James Parker | — | Seattle Mariners | Seattle Mariners signed SS James Parker. |
| Jul 20, 2021 | Signed | Jordan Jackson | — | Seattle Mariners | Seattle Mariners signed RHP Jordan Jackson. |
| Jul 20, 2021 | Signed | Corey Rosier | — | Seattle Mariners | Seattle Mariners signed OF Corey Rosier. |
| Jul 20, 2021 | Signed | Ben Ramirez | — | Seattle Mariners | Seattle Mariners signed SS Ben Ramirez. |
| Jul 20, 2021 | Signed | Jimmy Joyce | — | Seattle Mariners | Seattle Mariners signed RHP Jimmy Joyce. |
| Jul 20, 2021 | Signed | Jimmy Kingsbury | — | Seattle Mariners | Seattle Mariners signed RHP Jimmy Kingsbury. |
| Jul 20, 2021 | Signed | Charlie Welch | — | Seattle Mariners | Seattle Mariners signed C Charlie Welch. |
| Jul 20, 2021 | Signed as free agent | Peyton Alford | — | Seattle Mariners | Seattle Mariners signed free agent LHP Peyton Alford to a minor league contract. |
| Jul 20, 2021 | Released | Andy Burns | — | Los Angeles Dodgers | Los Angeles Dodgers released 3B Andy Burns. |
| Jul 20, 2021 | Signed | Riley Davis | — | Seattle Mariners | Seattle Mariners signed RHP Riley Davis. |
| Jul 20, 2021 | Signed as free agent | Randy Bednar | — | Seattle Mariners | Seattle Mariners signed free agent OF Randy Bednar to a minor league contract. |
| Jul 20, 2021 | Signed | Chris Nunn | — | Minnesota Twins | Minnesota Twins signed LHP Chris Nunn. |
| Jul 20, 2021 | Signed as free agent | Amilcar Chirinos | — | Houston Astros | Houston Astros signed free agent RHP Amilcar Chirinos to a minor league contract. |
| Jul 20, 2021 | Signed as free agent | Ankeily Feliz | — | San Francisco Giants | San Francisco Giants signed free agent RHP Ankeily Feliz to a minor league contract. |
| Jul 20, 2021 | Signed as free agent | Axel Rosario | — | Kansas City Royals | Kansas City Royals signed free agent RHP Axel Rosario to a minor league contract. |
| Jul 20, 2021 | Signed | Brant Hurter | — | Detroit Tigers | Detroit Tigers signed LHP Brant Hurter. |
| Jul 20, 2021 | Signed | Aaron Haase | — | Detroit Tigers | Detroit Tigers signed RHP Aaron Haase. |
| Jul 20, 2021 | Signed | Garrett Burhenn | — | Detroit Tigers | Detroit Tigers signed RHP Garrett Burhenn. |
| Jul 20, 2021 | Signed as free agent | Eduardo Torres | — | Baltimore Orioles | Baltimore Orioles signed free agent RHP Eduardo Torres to a minor league contract. |
| Jul 20, 2021 | Signed as free agent | Tristan Garnett | — | Philadelphia Phillies | Philadelphia Phillies signed free agent LHP Tristan Garnett to a minor league contract. |
| Jul 20, 2021 | Signed | Luke Boyd | — | San Diego Padres | San Diego Padres signed RHP Luke Boyd. |
| Jul 20, 2021 | Signed | Chad Stevens | — | Houston Astros | Houston Astros signed SS Chad Stevens. |
| Jul 20, 2021 | Signed | Kobe Kato | — | Houston Astros | Houston Astros signed 2B Kobe Kato. |
| Jul 20, 2021 | Signed as free agent | Kasey Ford | — | Houston Astros | Houston Astros signed free agent RHP Kasey Ford to a minor league contract. |
| Jul 20, 2021 | Signed as free agent | Deylen Miley | — | Houston Astros | Houston Astros signed free agent RHP Deylen Miley to a minor league contract. |
| Jul 20, 2021 | Signed | Carson Seymour | — | New York Mets | New York Mets signed RHP Carson Seymour. |
| Jul 20, 2021 | Signed | Levi David | — | New York Mets | New York Mets signed RHP Levi David. |
| Jul 20, 2021 | Signed | Keyshawn Askew | — | New York Mets | New York Mets signed LHP Keyshawn Askew. |
| Jul 20, 2021 | Signed | Rowdey Jordan | — | New York Mets | New York Mets signed OF Rowdey Jordan. |
| Jul 20, 2021 | Signed | Ky Bush | — | Los Angeles Angels | Los Angeles Angels signed LHP Ky Bush. |
| Jul 20, 2021 | Signed as free agent | Kyle Backhus | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent LHP Kyle Backhus to a minor league contract. |
| Jul 20, 2021 | Signed as free agent | Tommy McCollum | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RHP Tommy McCollum to a minor league contract. |
| Jul 20, 2021 | Signed | Cam Wynne | — | Philadelphia Phillies | Philadelphia Phillies signed RHP Cam Wynne. |
| Jul 20, 2021 | Signed as free agent | Ethan Routzahn | — | San Diego Padres | San Diego Padres signed free agent RHP Ethan Routzahn to a minor league contract. |
| Jul 20, 2021 | Signed | TJ Rumfield | — | Philadelphia Phillies | Philadelphia Phillies signed 3B T.J. Rumfield. |
| Jul 20, 2021 | Signed | Jared Carr | — | Philadelphia Phillies | Philadelphia Phillies signed OF Jared Carr. |
| Jul 20, 2021 | Signed as free agent | Freylin Minyety | — | Philadelphia Phillies | Philadelphia Phillies signed free agent SS Freylin Minyety to a minor league contract. |
| Jul 20, 2021 | Signed as free agent | Jared Wetherbee | — | Philadelphia Phillies | Philadelphia Phillies signed free agent LHP Jared Wetherbee to a minor league contract. |
| Jul 20, 2021 | Signed as free agent | Anthony Quirion | — | Philadelphia Phillies | Philadelphia Phillies signed free agent C Anthony Quirion to a minor league contract. |
| Jul 20, 2021 | Signed as free agent | Konnor Ash | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RHP Konnor Ash to a minor league contract. |
| Jul 20, 2021 | Signed | Alex Garbrick | — | Philadelphia Phillies | Philadelphia Phillies signed RHP Alex Garbrick. |
| Jul 20, 2021 | Signed | Matt Osterberg | — | Philadelphia Phillies | Philadelphia Phillies signed LHP Matt Osterberg. |
| Jul 20, 2021 | Signed | Andrew Abbott | — | Cincinnati Reds | Cincinnati Reds signed LHP Andrew Abbott. |
| Jul 20, 2021 | Signed | Carson Williams | — | Tampa Bay Rays | Tampa Bay Rays signed SS Carson Williams. |
| Jul 20, 2021 | Signed as free agent | Matt Goodheart | — | Philadelphia Phillies | Philadelphia Phillies signed free agent 1B Matt Goodheart to a minor league contract. |
| Jul 20, 2021 | Signed | Malik Binns | — | Philadelphia Phillies | Philadelphia Phillies signed RHP Malik Binns. |
| Jul 20, 2021 | Signed | Jose Acuna | — | Philadelphia Phillies | Philadelphia Phillies signed LHP Jose Valadez-Acuna. |
| Jul 19, 2021 | Signed | Gordon Graceffo | — | St. Louis Cardinals | St. Louis Cardinals signed RHP Gordon Graceffo. |
| Jul 19, 2021 | Signed | Zane Mills | — | St. Louis Cardinals | St. Louis Cardinals signed RHP Zane Mills. |
| Jul 19, 2021 | Signed | Aaron McKeithan | — | St. Louis Cardinals | St. Louis Cardinals signed C Aaron McKeithan. |
| Jul 19, 2021 | Signed | Alex Cornwell | — | St. Louis Cardinals | St. Louis Cardinals signed LHP Alex Cornwell. |
| Jul 19, 2021 | Signed | Andrew Marrero | — | St. Louis Cardinals | St. Louis Cardinals signed RHP Andrew Marrero. |
| Jul 19, 2021 | Signed | Thomas Francisco | — | St. Louis Cardinals | St. Louis Cardinals signed 1B Thomas Francisco. |
| Jul 19, 2021 | Signed | Ty Madden | — | Detroit Tigers | Detroit Tigers signed RHP Ty Madden. |
| Jul 19, 2021 | Signed | Mitch Bratt | — | Texas Rangers | Texas Rangers signed LHP Mitch Bratt. |
| Jul 19, 2021 | Trade | Dillon Peters | Los Angeles Angels | Pittsburgh Pirates | Los Angeles Angels traded LHP Dillon Peters to Pittsburgh Pirates for cash. |
| Jul 19, 2021 | Signed | Brenden Dixon | — | Pittsburgh Pirates | Pittsburgh Pirates signed SS Brenden Dixon. |
| Jul 19, 2021 | Signed | Ben Kudrna | — | Kansas City Royals | Kansas City Royals signed RHP Ben Kudrna. |
| Jul 19, 2021 | Signed | Shane Panzini | — | Kansas City Royals | Kansas City Royals signed RHP Shane Panzini. |
| Jul 19, 2021 | Signed | Ryan Cepero | — | Kansas City Royals | Kansas City Royals signed SS Ryan Cepero. |
| Jul 19, 2021 | Signed | Spencer Schwellenbach | — | Atlanta Braves | Atlanta Braves signed RHP Spencer Schwellenbach. |
| Jul 19, 2021 | Signed | Luke Taggart | — | Colorado Rockies | Colorado Rockies signed RHP Luke Taggart. |
| Jul 19, 2021 | Signed | Tyler Mattison | — | Detroit Tigers | Detroit Tigers signed RHP Tyler Mattison. |
| Jul 19, 2021 | Signed | Tanner Kohlhepp | — | Detroit Tigers | Detroit Tigers signed RHP Tanner Kohlhepp. |
| Jul 19, 2021 | Signed | Austin Murr | — | Detroit Tigers | Detroit Tigers signed OF Austin Murr. |
| Jul 19, 2021 | Signed | Jordan Marks | — | Detroit Tigers | Detroit Tigers signed RHP Jordan Marks. |
| Jul 19, 2021 | Signed | Jacen Roberson | — | Arizona Diamondbacks | Arizona Diamondbacks signed OF Jacen Roberson. |
| Jul 19, 2021 | Signed | Jack Rogers | — | Cincinnati Reds | Cincinnati Reds signed OF Jack Rogers. |
| Jul 19, 2021 | Signed | Michael Trautwein | — | Cincinnati Reds | Cincinnati Reds signed C Michael Trautwein. |
| Jul 19, 2021 | Signed | Wyatt Young | — | New York Mets | New York Mets signed SS Wyatt Young. |
| Jul 19, 2021 | Signed | Sam Bachman | — | Los Angeles Angels | Los Angeles Angels signed RHP Sam Bachman. |
| Jul 19, 2021 | Signed | Luke Murphy | — | Los Angeles Angels | Los Angeles Angels signed RHP Luke Murphy. |
| Jul 19, 2021 | Signed | Nick Jones | — | Los Angeles Angels | Los Angeles Angels signed LHP Nick Jones. |
| Jul 19, 2021 | Signed | Braden Olthoff | — | Los Angeles Angels | Los Angeles Angels signed RHP Braden Olthoff. |
| Jul 19, 2021 | Signed | Andrew Peters | — | Los Angeles Angels | Los Angeles Angels signed RHP Andrew Peters. |
| Jul 19, 2021 | Signed | Joshua Báez | — | St. Louis Cardinals | St. Louis Cardinals signed OF Joshua Baez. |
| Jul 19, 2021 | Signed | Kevin Kopps | — | San Diego Padres | San Diego Padres signed RHP Kevin Kopps. |
| Jul 19, 2021 | Signed | Cole Hamilton | — | Washington Nationals | Washington Nationals signed C Cole Hamilton. |
| Jul 19, 2021 | Signed | Jarrett Gonzales | — | Washington Nationals | Washington Nationals signed C Jarrett Gonzales. |
| Jul 19, 2021 | Signed | Alek Jacob | — | San Diego Padres | San Diego Padres signed RHP Alek Jacob. |
| Jul 19, 2021 | Signed | Ben Sems | — | Colorado Rockies | Colorado Rockies signed SS Benjamin Sems. |
| Jul 19, 2021 | Signed as free agent | Aaron Northcraft | — | San Diego Padres | San Diego Padres signed free agent RHP Aaron Northcraft to a minor league contract. |
| Jul 19, 2021 | Signed | Robert Gasser | — | San Diego Padres | San Diego Padres signed LHP Robert Gasser. |
| Jul 19, 2021 | Signed | Garrett Hawkins | — | San Diego Padres | San Diego Padres signed RHP Garrett Hawkins. |
| Jul 19, 2021 | Signed | Jackson Wolf | — | San Diego Padres | San Diego Padres signed LHP Jackson Wolf. |
| Jul 19, 2021 | Signed | Jaden Fein | — | Washington Nationals | Washington Nationals signed OF Jaden Fein. |
| Jul 19, 2021 | Signed | Jacob Young | — | Washington Nationals | Washington Nationals signed OF Jacob Young. |
| Jul 19, 2021 | Signed | Cooper Kinney | — | Tampa Bay Rays | Tampa Bay Rays signed 2B Cooper Kinney. |
| Jul 19, 2021 | Signed | Jack Sinclair | — | Washington Nationals | Washington Nationals signed RHP Jack Sinclair. |
| Jul 19, 2021 | Signed | T.J. White | — | Washington Nationals | Washington Nationals signed OF T.J. White. |
| Jul 19, 2021 | Signed as free agent | Adam Scoggins | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent LHP Adam Scoggins to a minor league contract. |
| Jul 19, 2021 | Signed | Bailey Dees | — | New York Yankees | New York Yankees signed RHP Bailey Dees. |
| Jul 19, 2021 | Signed | Will Warren | — | New York Yankees | New York Yankees signed RHP Will Warren. |
| Jul 19, 2021 | Signed | Sean Hermann | — | New York Yankees | New York Yankees signed RHP Sean Hermann. |
| Jul 18, 2021 | Signed | Henry Davis | — | Pittsburgh Pirates | Pittsburgh Pirates signed C Henry Davis. |
| Jul 18, 2021 | Signed | Noah Cameron | — | Kansas City Royals | Kansas City Royals signed LHP Noah Cameron. |
| Jul 18, 2021 | Signed | Tyson Guerrero | — | Kansas City Royals | Kansas City Royals signed LHP Tyson Guerrero. |
| Jul 18, 2021 | Signed | Patrick Halligan | — | Kansas City Royals | Kansas City Royals signed RHP Patrick Halligan. |
| Jul 18, 2021 | Signed as free agent | Shane Carle | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Shane Carle to a minor league contract. |
| Jul 18, 2021 | Signed as free agent | Sal Romano | — | New York Yankees | New York Yankees signed free agent RHP Sal Romano to a minor league contract. |
| Jul 18, 2021 | Signed | Christian Robinson | — | Atlanta Braves | Atlanta Braves signed OF Christian Robinson. |
| Jul 18, 2021 | Signed as free agent | RobertAnthony Cruz | — | Washington Nationals | Washington Nationals signed free agent 2B RobertAnthony Cruz to a minor league contract. |
| Jul 18, 2021 | Signed | Tommy Sommer | — | Chicago White Sox | Chicago White Sox signed LHP Tommy Sommer. |
| Jul 18, 2021 | Signed | Patrick Monteverde | — | Miami Marlins | Miami Marlins signed LHP Pat Monteverde. |
| Jul 18, 2021 | Signed | Gabe Bierman | — | Miami Marlins | Miami Marlins signed RHP Gabe Bierman. |
| Jul 18, 2021 | Signed | Jake Schrand | — | Miami Marlins | Miami Marlins signed RHP Jake Schrand. |
| Jul 18, 2021 | Signed | JT Schwartz | — | New York Mets | New York Mets signed 1B JT Schwartz. |
| Jul 18, 2021 | Signed | Trey McLoughlin | — | New York Mets | New York Mets signed RHP Trey McLoughlin. |
| Jul 18, 2021 | Signed | Kolby Kubichek | — | New York Mets | New York Mets signed RHP Kolby Kubichek. |
| Jul 18, 2021 | Signed | Drake Osborn | — | New York Mets | New York Mets signed C Drake Osborn. |
| Jul 18, 2021 | Signed | Justin Guerrera | — | New York Mets | New York Mets signed SS Justin Guerrera. |
| Jul 18, 2021 | Signed | Ryan Costeiu | — | Los Angeles Angels | Los Angeles Angels signed RHP Ryan Costeiu. |
| Jul 18, 2021 | Signed as free agent | Brady Allen | — | Miami Marlins | Miami Marlins signed free agent OF Brady Allen to a minor league contract. |
| Jul 17, 2021 | Signed as free agent | Andrew Velazquez | — | New York Yankees | New York Yankees signed free agent SS Andrew Velazquez to a minor league contract. |
| Jul 17, 2021 | Trade | Victor Santos | Philadelphia Phillies | Boston Red Sox | Philadelphia Phillies traded RHP Victor Santos to Boston Red Sox. |
| Jul 17, 2021 | Signed | Colton Cowser | — | Baltimore Orioles | Baltimore Orioles signed OF Colton Cowser. |
| Jul 17, 2021 | Signed | Frank Mozzicato | — | Kansas City Royals | Kansas City Royals signed LHP Frank Mozzicato. |
| Jul 17, 2021 | Signed | Jackson Glenn | — | Pittsburgh Pirates | Pittsburgh Pirates signed 3B Jackson Glenn. |
| Jul 17, 2021 | Signed as free agent | Cody Mincey | — | Miami Marlins | Miami Marlins signed free agent RHP Cody Mincey to a minor league contract. |
| Jul 17, 2021 | Signed as free agent | Andrew Painter | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RHP Andrew Painter to a minor league contract. |
| Jul 17, 2021 | Signed | Dylan Dodd | — | Atlanta Braves | Atlanta Braves signed LHP Dylan Dodd. |
| Jul 17, 2021 | Signed | Dylan Spain | — | Atlanta Braves | Atlanta Braves signed RHP Dylan Spain. |
| Jul 17, 2021 | Signed | Ruben Ibarra | — | Cincinnati Reds | Cincinnati Reds signed 1B Ruben Ibarra. |
| Jul 17, 2021 | Signed | Michael Hobbs | — | Los Angeles Dodgers | Los Angeles Dodgers signed RHP Michael Hobbs. |
| Jul 17, 2021 | Signed | Lael Lockhart | — | Los Angeles Dodgers | Los Angeles Dodgers signed LHP Lael Lockhart. |
| Jul 17, 2021 | Signed as free agent | Steven Souza Jr. | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RF Steven Souza Jr. to a minor league contract. |
| Jul 17, 2021 | Signed | Christian Scott | — | New York Mets | New York Mets signed RHP Christian Scott. |
| Jul 17, 2021 | Signed | Brendan Beck | — | New York Yankees | New York Yankees signed RHP Brendan Beck. |
| Jul 17, 2021 | Signed | Cooper Bowman | — | New York Yankees | New York Yankees signed 2B Cooper Bowman. |
| Jul 17, 2021 | Signed | Chandler Champlain | — | New York Yankees | New York Yankees signed RHP Chandler Champlain. |
| Jul 17, 2021 | Signed | Ben Cowles | — | New York Yankees | New York Yankees signed SS Benjamin Cowles. |
| Jul 17, 2021 | Signed | Danny Watson | — | New York Yankees | New York Yankees signed RHP Danny Watson. |
| Jul 17, 2021 | Signed as free agent | Troy Cruz | — | Miami Marlins | Miami Marlins signed free agent RHP Troy Cruz to a minor league contract. |
| Jul 17, 2021 | Signed as free agent | Zach Barnes | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Zach Barnes to a minor league contract. |
| Jul 17, 2021 | Signed | Ross Carver | — | Arizona Diamondbacks | Arizona Diamondbacks signed RHP John Carver. |
| Jul 17, 2021 | Signed | Dominic Hambley | — | Chicago Cubs | Chicago Cubs signed RHP Dominic Hambley. |
| Jul 17, 2021 | Signed as free agent | Bryan Perez | — | Houston Astros | Houston Astros signed free agent RHP Bryan Perez to a minor league contract. |
| Jul 17, 2021 | Signed | Andrew Moore | — | Seattle Mariners | Seattle Mariners signed RHP Andrew Moore. |
| Jul 17, 2021 | Signed | Taylor Broadway | — | Chicago White Sox | Chicago White Sox signed RHP Taylor Broadway. |
| Jul 17, 2021 | Signed | Fraser Ellard | — | Chicago White Sox | Chicago White Sox signed LHP Fraser Ellard. |
| Jul 17, 2021 | Signed | Theo Denlinger | — | Chicago White Sox | Chicago White Sox signed RHP Theo Denlinger. |
| Jul 17, 2021 | Signed as free agent | Paxton Wallace | — | Los Angeles Angels | Los Angeles Angels signed free agent 3B Paxton Wallace to a minor league contract. |
| Jul 17, 2021 | Signed as free agent | Cade Cabbiness | — | Los Angeles Angels | Los Angeles Angels signed free agent OF Cade Cabbiness to a minor league contract. |
| Jul 17, 2021 | Signed as free agent | Myles Emmerson | — | Los Angeles Angels | Los Angeles Angels signed free agent C Myles Emmerson to a minor league contract. |
| Jul 17, 2021 | Signed | Ryan Bliss | — | Arizona Diamondbacks | Arizona Diamondbacks signed SS Ryan Bliss. |
| Jul 17, 2021 | Signed | Caleb Roberts | — | Arizona Diamondbacks | Arizona Diamondbacks signed C Caleb Roberts. |
| Jul 17, 2021 | Signed | Rhett Kouba | — | Houston Astros | Houston Astros signed RHP Rhett Kouba. |
| Jul 17, 2021 | Signed | Nic Swanson | — | Houston Astros | Houston Astros signed RHP Nic Swanson. |
| Jul 17, 2021 | Signed | Justin Williams | — | Houston Astros | Houston Astros signed 3B Justin Williams. |
| Jul 17, 2021 | Signed | Will Wagner | — | Houston Astros | Houston Astros signed 2B Will Wagner. |
| Jul 17, 2021 | Signed as free agent | Marshall Hunt | — | Houston Astros | Houston Astros signed free agent RHP Marshall Hunt to a minor league contract. |
| Jul 17, 2021 | Signed as free agent | Walker Brockhouse | — | Houston Astros | Houston Astros signed free agent RHP Walker Brockhouse to a minor league contract. |
| Jul 17, 2021 | Signed as free agent | Ray Gaither | — | Houston Astros | Houston Astros signed free agent RHP Ray Gaither to a minor league contract. |
| Jul 17, 2021 | Signed as free agent | Jacob DeLabio | — | Houston Astros | Houston Astros signed free agent RHP Jacob DeLabio to a minor league contract. |
| Jul 17, 2021 | Signed | Landon Marceaux | — | Los Angeles Angels | Los Angeles Angels signed RHP Landon Marceaux. |
| Jul 17, 2021 | Signed | Andrew Baker | — | Philadelphia Phillies | Philadelphia Phillies signed RHP Andrew Baker. |
| Jul 17, 2021 | Signed | Collin Sullivan | — | Arizona Diamondbacks | Arizona Diamondbacks signed RHP Collin Sullivan. |
| Jul 17, 2021 | Signed | Ethan Wilson | — | Philadelphia Phillies | Philadelphia Phillies signed OF Ethan Wilson. |
| Jul 17, 2021 | Signed | Jordan Viars | — | Philadelphia Phillies | Philadelphia Phillies signed OF Jordan Viars. |
| Jul 17, 2021 | Signed | Logan Cerny | — | Philadelphia Phillies | Philadelphia Phillies signed OF Logan Cerny. |
| Jul 17, 2021 | Signed | Christian McGowan | — | Philadelphia Phillies | Philadelphia Phillies signed RHP Christian McGowan. |
| Jul 17, 2021 | Signed | Gavin Tonkel | — | Philadelphia Phillies | Philadelphia Phillies signed OF Gavin Tonkel. |
| Jul 17, 2021 | Signed | Jose Pena Jr. | — | Philadelphia Phillies | Philadelphia Phillies signed RHP Jose Pena Jr.. |
| Jul 17, 2021 | Signed | Micah Ottenbreit | — | Philadelphia Phillies | Philadelphia Phillies signed RHP Micah Ottenbreit. |
| Jul 16, 2021 | Signed as free agent | René Rivera | — | Washington Nationals | Washington Nationals signed free agent C Rene Rivera. |
| Jul 16, 2021 | Signed | Michael Sandle | — | Houston Astros | Houston Astros signed OF Michael Sandle. |
| Jul 16, 2021 | Signed | Chayce McDermott | — | Houston Astros | Houston Astros signed RHP Chayce McDermott. |
| Jul 16, 2021 | Signed | Gunnar Hoglund | — | Toronto Blue Jays | Toronto Blue Jays signed RHP Gunnar Hoglund. |
| Jul 16, 2021 | Signed | Colton Gordon | — | Houston Astros | Houston Astros signed LHP Colton Gordon. |
| Jul 16, 2021 | Signed | Aaron Brown | — | Houston Astros | Houston Astros signed RHP Aaron Brown. |
| Jul 16, 2021 | Signed | Quincy Hamilton | — | Houston Astros | Houston Astros signed OF Quincy Hamilton. |
| Jul 16, 2021 | Signed | Connor Norby | — | Baltimore Orioles | Baltimore Orioles signed 2B Connor Norby. |
| Jul 16, 2021 | Signed | Mike Jarvis | — | Pittsburgh Pirates | Pittsburgh Pirates signed SS Mike Jarvis. |
| Jul 16, 2021 | Signed | Sean Sullivan | — | Pittsburgh Pirates | Pittsburgh Pirates signed RHP Sean Sullivan. |
| Jul 16, 2021 | Signed | Luke Brown | — | Pittsburgh Pirates | Pittsburgh Pirates signed OF Luke Brown. |
| Jul 16, 2021 | Signed | Justin Meis | — | Pittsburgh Pirates | Pittsburgh Pirates signed RHP Justin Meis. |
| Jul 16, 2021 | Signed | Drew Gray | — | Chicago Cubs | Chicago Cubs signed LHP Drew Gray. |
| Jul 16, 2021 | Signed | Parker Chavers | — | Chicago Cubs | Chicago Cubs signed OF Parker Chavers. |
| Jul 16, 2021 | Signed | Chase Watkins | — | Chicago Cubs | Chicago Cubs signed LHP Chase Watkins. |
| Jul 16, 2021 | Signed | Jordan Wicks | — | Chicago Cubs | Chicago Cubs signed LHP Jordan Wicks. |
| Jul 16, 2021 | Signed | Liam Spence | — | Chicago Cubs | Chicago Cubs signed SS Liam Spence. |
| Jul 16, 2021 | Signed | Casey Opitz | — | Chicago Cubs | Chicago Cubs signed C Casey Opitz. |
| Jul 16, 2021 | Signed | Peter Matt | — | Chicago Cubs | Chicago Cubs signed OF Peter Matt. |
| Jul 16, 2021 | Released | Stephen Tarpley | — | New York Mets | New York Mets released LHP Stephen Tarpley. |
| Jul 16, 2021 | Signed as free agent | Miguel Gonzalez | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Miguel Gonzalez to a minor league contract. |
| Jul 16, 2021 | Trade | Stephen Vogt | Arizona Diamondbacks | Atlanta Braves | Atlanta Braves traded 1B Mason Berne to Arizona Diamondbacks for C Stephen Vogt. |
| Jul 16, 2021 | Signed as free agent | Peniel Otano | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Peniel Otano to a minor league contract. |
| Jul 16, 2021 | Signed as free agent | Lenny Polanco | — | Minnesota Twins | Minnesota Twins signed free agent LHP Lenny Polanco to a minor league contract. |
| Jul 16, 2021 | Signed as free agent | Angel Benitez | — | New York Yankees | New York Yankees signed free agent RHP Angel Benitez to a minor league contract. |
| Jul 16, 2021 | Signed as free agent | Oscar Bonilla | — | Texas Rangers | Texas Rangers signed free agent LHP Oscar Bonilla to a minor league contract. |
| Jul 16, 2021 | Signed as free agent | Braudin Ciprian | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Braudin Ciprian to a minor league contract. |
| Jul 16, 2021 | Signed as free agent | Hamlet Vasquez | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Hamlet Vasquez to a minor league contract. |
| Jul 16, 2021 | Signed as free agent | Guillermo Cuevas | — | Chicago White Sox | Chicago White Sox signed free agent LHP Guillermo Cuevas to a minor league contract. |
| Jul 16, 2021 | Signed as free agent | Eiker Huizi | — | Minnesota Twins | Minnesota Twins signed free agent RHP Eiker Huizi to a minor league contract. |
| Jul 16, 2021 | Signed | Michael McGreevy | — | St. Louis Cardinals | St. Louis Cardinals signed RHP Michael McGreevy. |
| Jul 16, 2021 | Signed | Liam McGill | — | Atlanta Braves | Atlanta Braves signed C Liam McGill. |
| Jul 16, 2021 | Signed | Andrew Hoffmann | — | Atlanta Braves | Atlanta Braves signed RHP Andrew Hoffmann. |
| Jul 16, 2021 | Signed as free agent | Kyle Battle | — | New York Yankees | New York Yankees signed free agent OF Kyle Battle to a minor league contract. |
| Jul 16, 2021 | Signed as free agent | Straton Podaras | — | Los Angeles Angels | Los Angeles Angels signed free agent C Straton Podaras to a minor league contract. |
| Jul 16, 2021 | Signed | Brett Kerry | — | Los Angeles Angels | Los Angeles Angels signed RHP Brett Kerry. |
| Jul 16, 2021 | Signed | Jake Smith | — | Los Angeles Angels | Los Angeles Angels signed RHP Jake Smith. |
| Jul 16, 2021 | Signed | Eric Torres | — | Los Angeles Angels | Los Angeles Angels signed LHP Eric Torres. |
| Jul 16, 2021 | Signed | Brandon Dufault | — | Los Angeles Angels | Los Angeles Angels signed RHP Brandon Dufault. |
| Jul 16, 2021 | Signed | Nick Mondak | — | Los Angeles Angels | Los Angeles Angels signed LHP Nick Mondak. |
| Jul 16, 2021 | Signed | Griff McGarry | — | Philadelphia Phillies | Philadelphia Phillies signed RHP Griff McGarry. |
| Jul 16, 2021 | Signed | Jason Ruffcorn | — | Philadelphia Phillies | Philadelphia Phillies signed RHP Jason Ruffcorn. |
| Jul 15, 2021 | Signed as free agent | Eddy Tavarez | — | Miami Marlins | Miami Marlins signed free agent RHP Eddy Tavarez to a minor league contract. |
| Jul 15, 2021 | Signed as free agent | Bobby Wahl | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Bobby Wahl to a minor league contract. |
| Jul 15, 2021 | Signed as free agent | Erik Cha | — | Miami Marlins | Miami Marlins signed free agent LHP Erik Cha to a minor league contract. |
| Jul 15, 2021 | Trade | Deivy Grullón | Tampa Bay Rays | Chicago White Sox | Tampa Bay Rays traded C Deivy Grullon to Chicago White Sox. |
| Jul 15, 2021 | Trade | Joc Pederson | Chicago Cubs | Atlanta Braves | Chicago Cubs traded CF Joc Pederson to Atlanta Braves for 1B Bryce Ball. |
| Jul 15, 2021 | Signed | Matt Litwicki | — | Boston Red Sox | Boston Red Sox signed RHP Matt Litwicki. |
| Jul 15, 2021 | Signed | Riley Martin | — | Chicago Cubs | Chicago Cubs signed LHP Riley Martin. |
| Jul 15, 2021 | Signed | Gil Luna | — | Chicago White Sox | Chicago White Sox signed LHP Gil Luna Jr.. |
| Jul 15, 2021 | Signed | Christian Franklin | — | Chicago Cubs | Chicago Cubs signed OF Christian Franklin. |
| Jul 15, 2021 | Signed | Spencer Arrighetti | — | Houston Astros | Houston Astros signed RHP Spencer Arrighetti. |
| Jul 15, 2021 | Signed | Trent Baker | — | St. Louis Cardinals | St. Louis Cardinals signed RHP Trent Baker. |
| Jul 15, 2021 | Signed | Liam Hicks | — | Texas Rangers | Texas Rangers signed C Liam Hicks. |
| Jul 15, 2021 | Signed | C.J. Widger | — | Texas Rangers | Texas Rangers signed LHP C.J. Widger. |
| Jul 15, 2021 | Signed | Wyatt Hendrie | — | Pittsburgh Pirates | Pittsburgh Pirates signed C Wyatt Hendrie. |
| Jul 15, 2021 | Signed as free agent | Yoan Castillo | — | Houston Astros | Houston Astros signed free agent LHP Yoan Castillo to a minor league contract. |
| Jul 15, 2021 | Signed as free agent | Steven Rivas | — | Los Angeles Angels | Los Angeles Angels signed free agent OF Steven Rivas to a minor league contract. |
| Jul 15, 2021 | Signed as free agent | Preston Price | — | Baltimore Orioles | Baltimore Orioles signed free agent RHP Preston Price to a minor league contract. |
| Jul 15, 2021 | Signed as free agent | Carson Matthews | — | Los Angeles Angels | Los Angeles Angels signed free agent SS Carson Matthews to a minor league contract. |
| Jul 15, 2021 | Signed | Glenn Albanese Jr. | — | Los Angeles Angels | Los Angeles Angels signed RHP Glenn Albanese Jr.. |
| Jul 15, 2021 | Signed as free agent | Zach Grech | — | Los Angeles Angels | Los Angeles Angels signed free agent RHP Zach Grech to a minor league contract. |
| Jul 15, 2021 | Signed as free agent | Joey Walsh | — | Los Angeles Angels | Los Angeles Angels signed free agent LHP Joey Walsh to a minor league contract. |
| Jul 15, 2021 | Signed | Branden Boissiere | — | Washington Nationals | Washington Nationals signed OF Branden Boissiere. |
| Jul 15, 2021 | Signed | Michael Kirian | — | Washington Nationals | Washington Nationals signed LHP Michael Kirian. |
| Jul 15, 2021 | Signed | Cole Quintanilla | — | Washington Nationals | Washington Nationals signed RHP Cole Quintanilla. |
| Jul 14, 2021 | Signed as free agent | Mitchell Osnowitz | — | Minnesota Twins | Minnesota Twins signed free agent RHP Mitchell Osnowitz to a minor league contract. |
| Jul 14, 2021 | Signed as free agent | Adam Eaton | — | Los Angeles Angels | Los Angeles Angels signed free agent CF Adam Eaton. |
| Jul 14, 2021 | Signed as free agent | Carson Carter | — | Baltimore Orioles | Baltimore Orioles signed free agent RHP Carson Carter to a minor league contract. |
| Jul 14, 2021 | Signed as free agent | Daniel Federman | — | Baltimore Orioles | Baltimore Orioles signed free agent RHP Daniel Federman to a minor league contract. |
| Jul 14, 2021 | Signed | Logan Michaels | — | Baltimore Orioles | Baltimore Orioles signed C Logan Michaels. |
| Jul 14, 2021 | Signed as free agent | Deivi Diaz | — | Chicago White Sox | Chicago White Sox signed free agent LHP Deivi Diaz to a minor league contract. |
| Jul 14, 2021 | Signed as free agent | Juan Diaz | — | Washington Nationals | Washington Nationals signed free agent LHP Juan Diaz to a minor league contract. |
| Jul 14, 2021 | Signed as free agent | Mike Peabody | — | Los Angeles Angels | Los Angeles Angels signed free agent OF Mike Peabody to a minor league contract. |
| Jul 14, 2021 | Signed as free agent | Gabe Matthews | — | Los Angeles Angels | Los Angeles Angels signed free agent 1B Gabe Matthews to a minor league contract. |
| Jul 14, 2021 | Signed | Matthew McMillan | — | Los Angeles Angels | Los Angeles Angels signed RHP Matthew McMillan. |
| Jul 14, 2021 | Signed as free agent | Vojtech Mensik | — | Los Angeles Angels | Los Angeles Angels signed free agent 3B Vojtech Mensik to a minor league contract. |
| Jul 13, 2021 | Signed as free agent | Orlando Rodriguez | — | Minnesota Twins | Minnesota Twins signed free agent RHP Orlando Rodriguez to a minor league contract. |
| Jul 13, 2021 | Trade | Kyle Lobstein | Washington Nationals | Milwaukee Brewers | Washington Nationals traded LHP Kyle Lobstein to Milwaukee Brewers for cash. |
| Jul 13, 2021 | Released | Bobby Wahl | — | Los Angeles Dodgers | Los Angeles Dodgers released RHP Bobby Wahl. |
| Jul 13, 2021 | Released | Aaron Northcraft | — | San Diego Padres | San Diego Padres released RHP Aaron Northcraft. |
| Jul 13, 2021 | Signed as free agent | Fernando Vargas | — | Chicago White Sox | Chicago White Sox signed free agent RF Fernando Vargas to a minor league contract. |
| Jul 13, 2021 | Signed as free agent | Jesael Cabrera | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Jesael Cabrera to a minor league contract. |
| Jul 13, 2021 | Signed as free agent | Juan Paulino | — | Washington Nationals | Washington Nationals signed free agent C Juan Paulino to a minor league contract. |
| Jul 13, 2021 | Released | Adam Eaton | — | Chicago White Sox | Chicago White Sox released CF Adam Eaton. |
| Jul 13, 2021 | Signed as free agent | Kole Enright | — | Miami Marlins | Miami Marlins signed free agent 3B Kole Enright to a minor league contract. |
| Jul 13, 2021 | Signed as free agent | Darling Solano | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Darling Solano to a minor league contract. |
| Jul 13, 2021 | Signed as free agent | Douglas Orellana | — | New York Mets | New York Mets signed free agent RHP Douglas Orellana to a minor league contract. |
| Jul 13, 2021 | Signed as free agent | Javier Velasquez | — | Cincinnati Reds | Cincinnati Reds signed free agent OF Javier Velasquez to a minor league contract. |
| Jul 13, 2021 | Signed as free agent | Zach Humphreys | — | Los Angeles Angels | Los Angeles Angels signed free agent C Zach Humphreys to a minor league contract. |
| Jul 13, 2021 | Signed as free agent | Griffin Mazur | — | Los Angeles Angels | Los Angeles Angels signed free agent C Griffin Mazur to a minor league contract. |
| Jul 13, 2021 | Signed as free agent | Kenyon Yovan | — | Los Angeles Angels | Los Angeles Angels signed free agent 1B Kenyon Yovan to a minor league contract. |
| Jul 13, 2021 | Signed as free agent | Christian Molfetta | — | Los Angeles Angels | Los Angeles Angels signed free agent C Christian Molfetta to a minor league contract. |
| Jul 13, 2021 | Signed | Nathan Burns | — | Los Angeles Angels | Los Angeles Angels signed RHP Nathan Burns. |
| Jul 13, 2021 | Signed | Kyle Lovelace | — | Los Angeles Angels | Los Angeles Angels signed C Kyle Lovelace. |
| Jul 12, 2021 | Signed as free agent | Taylor Bloye | — | Kansas City Royals | Kansas City Royals signed free agent Taylor Bloye to a minor league contract. |
| Jul 12, 2021 | Signed as free agent | Sebastian Santana | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Sebastian Santana to a minor league contract. |
| Jul 12, 2021 | Signed as free agent | Jason Adam | — | Chicago Cubs | Chicago Cubs signed free agent RHP Jason Adam to a minor league contract. |
| Jul 12, 2021 | Signed as free agent | Osvaldo Tovalin | — | St. Louis Cardinals | St. Louis Cardinals signed free agent 3B Osvaldo Tovalin to a minor league contract. |
| Jul 12, 2021 | Signed | Alfredo Ruiz | — | St. Louis Cardinals | St. Louis Cardinals signed LHP Alfredo Ruiz. |
| Jul 12, 2021 | Signed | Mike Antico | — | St. Louis Cardinals | St. Louis Cardinals signed OF Mike Antico. |
| Jul 12, 2021 | Signed | Chase Lee | — | Texas Rangers | Texas Rangers signed RHP Chase Lee. |
| Jul 12, 2021 | Signed | Bradford Webb | — | Texas Rangers | Texas Rangers signed RHP Bradford Webb. |
| Jul 12, 2021 | Signed as free agent | Bryan Polanco | — | Washington Nationals | Washington Nationals signed free agent RHP Bryan Polanco to a minor league contract. |
| Jul 12, 2021 | Signed as free agent | Adrian Ogando | — | Washington Nationals | Washington Nationals signed free agent RHP Adrian Ogando to a minor league contract. |
| Jul 11, 2021 | Signed as free agent | Brandon Barker | — | Kansas City Royals | Kansas City Royals signed free agent RHP Brandon Barker to a minor league contract. |
| Jul 11, 2021 | Released | Steven Souza Jr. | — | Los Angeles Dodgers | Los Angeles Dodgers released RF Steven Souza Jr.. |
| Jul 11, 2021 | Trade | Tyler Neslony | Atlanta Braves | Chicago White Sox | Atlanta Braves traded RF Tyler Neslony to Chicago White Sox. |
| Jul 10, 2021 | Trade | Hugo Beltran | Los Angeles Dodgers | Baltimore Orioles | Los Angeles Dodgers traded RHP Hugo Beltran to Baltimore Orioles for cash. |
| Jul 10, 2021 | Signed as free agent | Vitico Valdez | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Vitico Valdez to a minor league contract. |
| Jul 9, 2021 | Signed as free agent | Luis García | — | St. Louis Cardinals | St. Louis Cardinals signed free agent RHP Luis Garcia. |
| Jul 9, 2021 | Trade | Damon Casetta-Stubbs | Seattle Mariners | Cleveland Guardians | Seattle Mariners traded RHP Damon Casetta-Stubbs to Cleveland Indians. |
| Jul 9, 2021 | Signed as free agent | Liam Sabino | — | Seattle Mariners | Seattle Mariners signed free agent 3B Liam Sabino to a minor league contract. |
| Jul 9, 2021 | Signed as free agent | Derek Dietrich | — | Washington Nationals | Washington Nationals signed free agent 2B Derek Dietrich to a minor league contract. |
| Jul 9, 2021 | Signed as free agent | Dean Nevarez | — | Chicago Cubs | Chicago Cubs signed free agent C Dean Nevarez to a minor league contract. |
| Jul 9, 2021 | Signed as free agent | Eric Martinez | — | Milwaukee Brewers | Milwaukee Brewers signed free agent C Eric Martinez to a minor league contract. |
| Jul 9, 2021 | Signed as free agent | Brawny Reyes | — | New York Mets | New York Mets signed free agent RHP Brawny Reyes to a minor league contract. |
| Jul 8, 2021 | Signed as free agent | Dee Strange-Gordon | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent 2B Dee Strange-Gordon to a minor league contract. |
| Jul 8, 2021 | Trade | Darlin Guzman | Cincinnati Reds | Toronto Blue Jays | Cincinnati Reds traded OF Darlin Guzman to Toronto Blue Jays. |
| Jul 8, 2021 | Released | René Rivera | — | Cleveland Guardians | Cleveland Indians released C Rene Rivera. |
| Jul 8, 2021 | Signed as free agent | Demetrio Nadal | — | Milwaukee Brewers | Milwaukee Brewers signed free agent SS Demetrio Nadal to a minor league contract. |
| Jul 8, 2021 | Signed as free agent | Henrison Mota | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Henrison Mota to a minor league contract. |
| Jul 8, 2021 | Signed | Jose Geraldo | — | Seattle Mariners | Seattle Mariners signed P Jose Giraldo. |
| Jul 8, 2021 | Signed as free agent | Hansel Rosario | — | New York Yankees | New York Yankees signed free agent RHP Hansel Rosario to a minor league contract. |
| Jul 7, 2021 | Signed as free agent | Cam Bedrosian | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RHP Cam Bedrosian to a minor league contract. |
| Jul 7, 2021 | Trade | Joe Kuzia | Texas Rangers | Minnesota Twins | Texas Rangers traded RHP Joe Kuzia to Minnesota Twins. |
| Jul 7, 2021 | Signed as free agent | Edwar Alvarado | — | Colorado Rockies | Colorado Rockies signed free agent C Edwar Alvarado to a minor league contract. |
| Jul 7, 2021 | Signed as free agent | Eybersson Polanco | — | Boston Red Sox | Boston Red Sox signed free agent RHP Eybersson Polanco to a minor league contract. |
| Jul 6, 2021 | Trade | Nathan Kirby | Milwaukee Brewers | Pittsburgh Pirates | Milwaukee Brewers traded LHP Nathan Kirby to Pittsburgh Pirates. |
| Jul 6, 2021 | Trade | Trevor Richards | Milwaukee Brewers | Toronto Blue Jays | Toronto Blue Jays traded 1B Rowdy Tellez to Milwaukee Brewers for RHP Bowden Francis and RHP Trevor Richards. |
| Jul 6, 2021 | Signed as free agent | Wilson Ramos | — | Cleveland Guardians | Cleveland Indians signed free agent C Wilson Ramos to a minor league contract. |
| Jul 6, 2021 | Signed as free agent | Nick Goody | — | Washington Nationals | Washington Nationals signed free agent RHP Nick Goody to a minor league contract. |
| Jul 6, 2021 | Signed as free agent | Angel Tello | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Angel Tello to a minor league contract. |
| Jul 5, 2021 | Signed as free agent | Robinson Chirinos | — | Chicago Cubs | Chicago Cubs signed free agent C Robinson Chirinos. |
| Jul 5, 2021 | Signed as free agent | Breckin Williams | — | Minnesota Twins | Minnesota Twins signed free agent RHP Breckin Williams to a minor league contract. |
| Jul 5, 2021 | Signed as free agent | Gregori Vasquez | — | Baltimore Orioles | Baltimore Orioles signed free agent RHP Gregori Vasquez to a minor league contract. |
| Jul 5, 2021 | Signed as free agent | Tanner Anderson | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent RHP Tanner Anderson to a minor league contract. |
| Jul 5, 2021 | Signed as free agent | Neftalí Feliz | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Neftali Feliz to a minor league contract. |
| Jul 5, 2021 | Signed as free agent | Joldelanio De Los Santos | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Joldelanio De Los Santos to a minor league contract. |
| Jul 5, 2021 | Signed as free agent | Alejandro Gomez | — | New York Yankees | New York Yankees signed free agent RHP Alejandro Gomez to a minor league contract. |
| Jul 5, 2021 | Signed as free agent | Wuillians Herrera | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Wuillians Herrera to a minor league contract. |
| Jul 5, 2021 | Signed as free agent | Reynaldo Yean | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Reynaldo Yean to a minor league contract. |
| Jul 4, 2021 | Signed as free agent | Diego Moreno | — | Washington Nationals | Washington Nationals signed free agent RHP Diego Moreno to a minor league contract. |
| Jul 4, 2021 | Trade | Kevin Kramer | Pittsburgh Pirates | Milwaukee Brewers | Pittsburgh Pirates traded 3B Kevin Kramer to Milwaukee Brewers. |
| Jul 4, 2021 | Signed as free agent | Tyler Alexander | — | Philadelphia Phillies | Philadelphia Phillies signed free agent LHP Tyler Alexander to a minor league contract. |
| Jul 3, 2021 | Trade | Kelvin Gutiérrez | Kansas City Royals | Baltimore Orioles | Kansas City Royals traded 3B Kelvin Gutierrez to Baltimore Orioles for cash. |
| Jul 3, 2021 | Trade | David Hess | Tampa Bay Rays | Miami Marlins | Tampa Bay Rays traded RHP David Hess to Miami Marlins for RHP Justin Sterner and cash. |
| Jul 3, 2021 | Trade | Alcides Escobar | Kansas City Royals | Washington Nationals | Kansas City Royals traded SS Alcides Escobar to Washington Nationals for cash. |
| Jul 3, 2021 | Signed as free agent | Shane Carle | — | Seattle Mariners | Seattle Mariners signed free agent RHP Shane Carle to a minor league contract. |
| Jul 3, 2021 | Trade | John Nogowski | St. Louis Cardinals | Pittsburgh Pirates | St. Louis Cardinals traded 1B John Nogowski to Pittsburgh Pirates. |
| Jul 3, 2021 | Signed as free agent | Tyler Heineman | — | Philadelphia Phillies | Philadelphia Phillies signed free agent C Tyler Heineman to a minor league contract. |
| Jul 3, 2021 | Signed as free agent | Carlos Gazo | — | San Francisco Giants | San Francisco Giants signed free agent RHP Carlos Gazo to a minor league contract. |
| Jul 2, 2021 | Trade | Anthony Banda | San Francisco Giants | New York Mets | San Francisco Giants traded LHP Anthony Banda to New York Mets for 3B Will Toffey. |
| Jul 2, 2021 | Signed as free agent | Joe Harvey | — | Minnesota Twins | Minnesota Twins signed free agent RHP Joe Harvey to a minor league contract. |
| Jul 2, 2021 | Trade | Sam Moll | Arizona Diamondbacks | Athletics | Arizona Diamondbacks traded LHP Sam Moll to Oakland Athletics for cash. |
| Jul 2, 2021 | Signed as free agent | Zach Goree | — | Minnesota Twins | Minnesota Twins signed free agent LHP Zachary Goree to a minor league contract. |
| Jul 2, 2021 | Signed as free agent | Pedro Figueroa | — | Baltimore Orioles | Baltimore Orioles signed free agent RHP Pedro Figueroa to a minor league contract. |
| Jul 2, 2021 | Signed as free agent | Cesar Perdomo | — | San Francisco Giants | San Francisco Giants signed free agent LHP Cesar Perdomo to a minor league contract. |
| Jul 2, 2021 | Signed as free agent | Jose Ledesma | — | New York Yankees | New York Yankees signed free agent LHP Jose Ledesma to a minor league contract. |
| Jul 2, 2021 | Signed as free agent | Andy Lugo | — | Boston Red Sox | Boston Red Sox signed free agent 3B Andy Lugo to a minor league contract. |
| Jul 2, 2021 | Signed as free agent | Christopher Torres | — | San Francisco Giants | San Francisco Giants signed free agent RHP Christopher Torres to a minor league contract. |
| Jul 2, 2021 | Signed as free agent | Daniel Nunez | — | Boston Red Sox | Boston Red Sox signed free agent LHP Bryant Nunez to a minor league contract. |
| Jul 2, 2021 | Signed as free agent | Guillermo Williamson | — | San Francisco Giants | San Francisco Giants signed free agent LF Guillermo Williamson to a minor league contract. |
| Jul 2, 2021 | Signed as free agent | Egory Manuela | — | Tampa Bay Rays | Tampa Bay Rays signed free agent LHP Egory Manuela to a minor league contract. |
| Jul 1, 2021 | Trade | Keegan Curtis | New York Yankees | Arizona Diamondbacks | Arizona Diamondbacks traded LF Tim Locastro to New York Yankees for RHP Keegan Curtis. |
| Jul 1, 2021 | Signed as free agent | T.J. McFarland | — | St. Louis Cardinals | St. Louis Cardinals signed free agent LHP T.J. McFarland to a minor league contract. |
| Jul 1, 2021 | Signed as free agent | Shelby Miller | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent RHP Shelby Miller to a minor league contract. |
| Jul 1, 2021 | Signed as free agent | Luke Westphal | — | San Diego Padres | San Diego Padres signed free agent LHP Luke Westphal to a minor league contract. |
| Jul 1, 2021 | Trade | Aldenis Sanchez | Tampa Bay Rays | New York Yankees | Tampa Bay Rays traded OF Aldenis Sanchez to New York Yankees. |
| Jul 1, 2021 | Signed as free agent | Jonah Girand | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent C Jonah Girand to a minor league contract. |
| Jul 1, 2021 | Signed as free agent | Alex Sanabia | — | New York Mets | New York Mets signed free agent RHP Alex Sanabia to a minor league contract. |
| Jul 1, 2021 | Signed as free agent | Nate Peden | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Nate Peden to a minor league contract. |
| Jul 1, 2021 | Signed as free agent | Christian Tripp | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Christian Tripp to a minor league contract. |
| Jul 1, 2021 | Signed as free agent | Edwar Polimir | — | New York Yankees | New York Yankees signed free agent LHP Edwar Polimir to a minor league contract. |
| Jul 1, 2021 | Signed as free agent | Michael Peres | — | New York Yankees | New York Yankees signed free agent LHP Michael Perez to a minor league contract. |
| Jul 1, 2021 | Signed as free agent | Juan Rosa | — | New York Yankees | New York Yankees signed free agent CF Juan Rosa to a minor league contract. |
| Jul 1, 2021 | Signed as free agent | Brian Arias | — | New York Yankees | New York Yankees signed free agent RHP Brian Arias to a minor league contract. |
| Jun 30, 2021 | Signed as free agent | Drew Stankiewicz | — | Minnesota Twins | Minnesota Twins signed free agent 2B Drew Stankiewicz to a minor league contract. |
| Jun 30, 2021 | Signed as free agent | Dustin Beggs | — | New York Mets | New York Mets signed free agent RHP Dustin Beggs to a minor league contract. |
| Jun 30, 2021 | Signed as free agent | Jordarlin Mendoza | — | New York Yankees | New York Yankees signed free agent RHP Jordarlin Mendoza to a minor league contract. |
| Jun 30, 2021 | Signed as free agent | Daniel Guerrero | — | New York Yankees | New York Yankees signed free agent RHP Daniel Guerrero to a minor league contract. |
| Jun 30, 2021 | Signed as free agent | Jhon Imbert | — | New York Yankees | New York Yankees signed free agent SS Jhon Imbert to a minor league contract. |
| Jun 30, 2021 | Signed as free agent | Franklin Van Gurp | — | Seattle Mariners | Seattle Mariners signed free agent RHP Franklin Van Gurp to a minor league contract. |
| Jun 30, 2021 | Signed as free agent | Adam Heidenfelder | — | Chicago Cubs | Chicago Cubs signed free agent RHP Adam Heidenfelder to a minor league contract. |
| Jun 30, 2021 | Signed as free agent | Matthias Dietz | — | Los Angeles Angels | Los Angeles Angels signed free agent RHP Matthias Dietz to a minor league contract. |
| Jun 30, 2021 | Signed as free agent | Juan Sanchez | — | New York Yankees | New York Yankees signed free agent C Juan Sanchez to a minor league contract. |
| Jun 29, 2021 | Signed as free agent | Hunter Speer | — | Chicago White Sox | Chicago White Sox signed free agent RHP Hunter Speer to a minor league contract. |
| Jun 29, 2021 | Signed as free agent | Sean Gilmartin | — | Minnesota Twins | Minnesota Twins signed free agent LHP Sean Gilmartin to a minor league contract. |
| Jun 29, 2021 | Trade | Corey Dickerson | Miami Marlins | Toronto Blue Jays | Miami Marlins traded LF Corey Dickerson, RHP Adam Cimber and cash to Toronto Blue Jays for 2B Joe Panik and RHP Andrew McInvale. |
| Jun 29, 2021 | Signed as free agent | Zack Godley | — | Cleveland Guardians | Cleveland Indians signed free agent RHP Zack Godley to a minor league contract. |
| Jun 29, 2021 | Signed as free agent | Emilio Afanador | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP Emilio Afanador to a minor league contract. |
| Jun 28, 2021 | Signed as free agent | Eric Jones | — | Seattle Mariners | Seattle Mariners signed free agent C Eric Jones to a minor league contract. |
| Jun 28, 2021 | Trade | Matt Lipka | Arizona Diamondbacks | Milwaukee Brewers | Arizona Diamondbacks traded CF Matt Lipka to Milwaukee Brewers for cash. |
| Jun 28, 2021 | Signed as free agent | Nolan Clenney | — | New York Mets | New York Mets signed free agent RHP Nolan Clenney to a minor league contract. |
| Jun 28, 2021 | Signed as free agent | Evy Ruibal | — | New York Mets | New York Mets signed free agent RHP Evy Ruibal to a minor league contract. |
| Jun 28, 2021 | Signed as free agent | Nate Fisher | — | Seattle Mariners | Seattle Mariners signed free agent LHP Nate Fisher to a minor league contract. |
| Jun 28, 2021 | Signed as free agent | Felix Arronde | — | Kansas City Royals | Kansas City Royals signed free agent RHP Felix Arronde to a minor league contract. |
| Jun 27, 2021 | Signed as free agent | Dalton Stambaugh | — | Chicago Cubs | Chicago Cubs signed free agent LHP Dalton Stambaugh to a minor league contract. |
| Jun 27, 2021 | Signed as free agent | Kevin Watson Jr | — | Los Angeles Angels | Los Angeles Angels signed free agent CF Kevin Watson Jr. to a minor league contract. |
| Jun 27, 2021 | Signed as free agent | Connor Sechler | — | Texas Rangers | Texas Rangers signed free agent RHP Connor Sechler to a minor league contract. |
| Jun 26, 2021 | Signed as free agent | D.J. Burt | — | Minnesota Twins | Minnesota Twins signed free agent 2B D.J. Burt to a minor league contract. |
| Jun 25, 2021 | Trade | Samuel Escudero | Milwaukee Brewers | Pittsburgh Pirates | Pittsburgh Pirates traded LF Troy Stokes Jr. and RHP Jandel Gustave to Milwaukee Brewers for C Samuel Escudero. |
| Jun 25, 2021 | Signed as free agent | Brad Peacock | — | Cleveland Guardians | Cleveland Indians signed free agent RHP Brad Peacock to a minor league contract. |
| Jun 25, 2021 | Signed as free agent | Alex Powers | — | San Diego Padres | San Diego Padres signed free agent RHP Alex Powers to a minor league contract. |
| Jun 25, 2021 | Signed as free agent | Luke Leftwich | — | Los Angeles Angels | Los Angeles Angels signed free agent RHP Luke Leftwich to a minor league contract. |
| Jun 25, 2021 | Signed as free agent | Mason Williams | — | New York Mets | New York Mets signed free agent CF Mason Williams to a minor league contract. |
| Jun 25, 2021 | Signed as free agent | Jason Ollarve | — | Milwaukee Brewers | Milwaukee Brewers signed free agent C Jason Ollarve to a minor league contract. |
| Jun 25, 2021 | Signed as free agent | Angel Santana | — | Kansas City Royals | Kansas City Royals signed free agent 3B Angel Santana to a minor league contract. |
| Jun 25, 2021 | Signed as free agent | Junior William | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP Junior William to a minor league contract. |
| Jun 25, 2021 | Signed as free agent | Juan Reynoso | — | Miami Marlins | Miami Marlins signed free agent Juan Reynoso to a minor league contract. |
| Jun 25, 2021 | Signed as free agent | Geuri Lubo | — | Chicago Cubs | Chicago Cubs signed free agent SS Geuri Lubo to a minor league contract. |
| Jun 25, 2021 | Signed as free agent | Cesar De Jesus | — | Tampa Bay Rays | Tampa Bay Rays signed free agent LHP Cesar De Jesus to a minor league contract. |
| Jun 24, 2021 | Trade | Wyatt Mathisen | Tampa Bay Rays | Seattle Mariners | Tampa Bay Rays traded 3B Wyatt Mathisen to Seattle Mariners for cash. |
| Jun 24, 2021 | Signed as free agent | Vance Worley | — | New York Mets | New York Mets signed free agent RHP Vance Worley to a minor league contract. |
| Jun 24, 2021 | Signed as free agent | Daniel Duarte | — | Cincinnati Reds | Cincinnati Reds signed free agent RHP Daniel Duarte to a minor league contract. |
| Jun 24, 2021 | Signed as free agent | Cole Stringer | — | Colorado Rockies | Colorado Rockies signed free agent LHP Cole Stringer to a minor league contract. |
| Jun 24, 2021 | Signed as free agent | John Axford | — | Toronto Blue Jays | Toronto Blue Jays signed free agent RHP John Axford to a minor league contract. |
| Jun 24, 2021 | Signed as free agent | Nathan Sweeney | — | Colorado Rockies | Colorado Rockies signed free agent RHP Nathan Sweeney to a minor league contract. |
| Jun 24, 2021 | Signed as free agent | Joshua Rivera | — | Kansas City Royals | Kansas City Royals signed free agent SS Joshua Rivera to a minor league contract. |
| Jun 24, 2021 | Signed as free agent | Moises Diaz | — | Washington Nationals | Washington Nationals signed free agent RHP Moises Diaz to a minor league contract. |
| Jun 24, 2021 | Signed as free agent | Aaron Rozek | — | Minnesota Twins | Minnesota Twins signed free agent LHP Aaron Rozek to a minor league contract. |
| Jun 23, 2021 | Signed as free agent | Nick Vincent | — | Minnesota Twins | Minnesota Twins signed free agent RHP Nick Vincent to a minor league contract. |
| Jun 23, 2021 | Signed as free agent | Reilly Hovis | — | Toronto Blue Jays | Toronto Blue Jays signed free agent RHP Reilly Hovis to a minor league contract. |
| Jun 23, 2021 | Signed as free agent | Nelson Gonzalez | — | Colorado Rockies | Colorado Rockies signed free agent RHP Nelson Gonzalez to a minor league contract. |
| Jun 23, 2021 | Signed as free agent | Kipp Rollings | — | Kansas City Royals | Kansas City Royals signed free agent RHP Kipp Rollings to a minor league contract. |
| Jun 22, 2021 | Signed as free agent | Matt Warkentin | — | Chicago Cubs | Chicago Cubs signed free agent 1B Matt Warkentin to a minor league contract. |
| Jun 22, 2021 | Signed as free agent | Logan Landon | — | Philadelphia Phillies | Philadelphia Phillies signed free agent CF Logan Landon to a minor league contract. |
| Jun 22, 2021 | Signed as free agent | Logan Moore | — | Philadelphia Phillies | Philadelphia Phillies signed free agent C Logan Moore to a minor league contract. |
| Jun 22, 2021 | Signed as free agent | Brian Johnson | — | Los Angeles Angels | Los Angeles Angels signed free agent LHP Brian Johnson to a minor league contract. |
| Jun 22, 2021 | Signed as free agent | Justin Miller | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Justin Miller to a minor league contract. |
| Jun 22, 2021 | Signed as free agent | Jorge Ramirez | — | Washington Nationals | Washington Nationals signed free agent LHP Jorge Ramirez to a minor league contract. |
| Jun 22, 2021 | Signed as free agent | Manuel Castro | — | San Diego Padres | San Diego Padres signed free agent RHP Octavio Castro to a minor league contract. |
| Jun 22, 2021 | Signed as free agent | Alan Ramirez | — | Miami Marlins | Miami Marlins signed free agent LHP Alan Ramirez to a minor league contract. |
| Jun 22, 2021 | Signed as free agent | Williams Valencia | — | Miami Marlins | Miami Marlins signed free agent RHP Williams Valencia to a minor league contract. |
| Jun 22, 2021 | Signed as free agent | Homer Bailey | — | Athletics | Oakland Athletics signed free agent RHP Homer Bailey to a minor league contract. |
| Jun 21, 2021 | Signed as free agent | Abel Mercedes | — | Houston Astros | Houston Astros signed free agent RHP Abel Mercedes to a minor league contract. |
| Jun 21, 2021 | Signed as free agent | Jordan Hovey | — | Kansas City Royals | Kansas City Royals signed free agent 3B Jordan Hovey to a minor league contract. |
| Jun 20, 2021 | Signed as free agent | Jared Walker | — | Texas Rangers | Texas Rangers signed free agent 3B Jared Walker to a minor league contract. |
| Jun 20, 2021 | Signed as free agent | Kyle Barraclough | — | Minnesota Twins | Minnesota Twins signed free agent RHP Kyle Barraclough to a minor league contract. |
| Jun 20, 2021 | Signed as free agent | Andrew Bash | — | Toronto Blue Jays | Toronto Blue Jays signed free agent RHP Andrew Bash to a minor league contract. |
| Jun 20, 2021 | Released | Wilson Ramos | — | Detroit Tigers | Detroit Tigers released C Wilson Ramos. |
| Jun 19, 2021 | Trade | Troy Miller | Toronto Blue Jays | New York Mets | New York Mets traded RHP Jacob Barnes to Toronto Blue Jays for RHP Troy Miller. |
| Jun 19, 2021 | Signed as free agent | Akeel Morris | — | San Francisco Giants | San Francisco Giants signed free agent RHP Akeel Morris to a minor league contract. |
| Jun 19, 2021 | Signed as free agent | Kyle Hinton | — | Washington Nationals | Washington Nationals signed free agent RHP Kyle Hinton to a minor league contract. |
| Jun 19, 2021 | Signed as free agent | Jake Faria | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Jake Faria. |
| Jun 19, 2021 | Signed | Jhosmmel Zue | — | Pittsburgh Pirates | Pittsburgh Pirates signed C Jhosmmel Zue. |
| Jun 18, 2021 | Signed as free agent | Mallex Smith | — | Cincinnati Reds | Cincinnati Reds signed free agent CF Mallex Smith to a minor league contract. |
| Jun 18, 2021 | Signed as free agent | Enrique Santana | — | New York Yankees | New York Yankees signed free agent RHP Enrique Santana to a minor league contract. |
| Jun 18, 2021 | Signed as free agent | Daniel Familia | — | Houston Astros | Houston Astros signed free agent OF Daniel Familia to a minor league contract. |
| Jun 18, 2021 | Signed as free agent | Harrison Wenson | — | Chicago Cubs | Chicago Cubs signed free agent C Harrison Wenson to a minor league contract. |
| Jun 18, 2021 | Signed as free agent | Adrian Almonte | — | Tampa Bay Rays | Tampa Bay Rays signed free agent LHP Adrian Almonte to a minor league contract. |
| Jun 18, 2021 | Signed as free agent | Natanael Polanco | — | Miami Marlins | Miami Marlins signed free agent RHP Natanael Polanco to a minor league contract. |
| Jun 17, 2021 | Trade | Mike Ford | New York Yankees | Tampa Bay Rays | New York Yankees traded 1B Mike Ford to Tampa Bay Rays for Player To Be Named Later and cash. |
| Jun 17, 2021 | Trade | Dennis Santana | Los Angeles Dodgers | Texas Rangers | Los Angeles Dodgers traded RHP Dennis Santana to Texas Rangers for LHP Kelvin Bautista. |
| Jun 17, 2021 | Signed as free agent | Blake Rogers | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Blake Rogers to a minor league contract. |
| Jun 17, 2021 | Signed as free agent | Wade LeBlanc | — | St. Louis Cardinals | St. Louis Cardinals signed free agent LHP Wade LeBlanc. |
| Jun 17, 2021 | Signed as free agent | Tyler Ferguson | — | Atlanta Braves | Atlanta Braves signed free agent RHP Tyler Ferguson to a minor league contract. |
| Jun 17, 2021 | Signed as free agent | Alen Hanson | — | Seattle Mariners | Seattle Mariners signed free agent 2B Alen Hanson to a minor league contract. |
| Jun 17, 2021 | Signed as free agent | Connor Grey | — | New York Mets | New York Mets signed free agent RHP Connor Grey to a minor league contract. |
| Jun 17, 2021 | Signed as free agent | Jesus Rivero | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Jesus Rivero to a minor league contract. |
| Jun 17, 2021 | Signed | Juan Amarante | — | Pittsburgh Pirates | Pittsburgh Pirates signed LHP Juan Amarante. |
| Jun 16, 2021 | Signed as free agent | Trey Hair | — | Texas Rangers | Texas Rangers signed free agent 2B Trey Hair to a minor league contract. |
| Jun 16, 2021 | Signed as free agent | Wilbis Santiago | — | Minnesota Twins | Minnesota Twins signed free agent 2B Wilbis Santiago to a minor league contract. |
| Jun 16, 2021 | Signed as free agent | Jordy Andujar | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP Jordy Andujar to a minor league contract. |
| Jun 15, 2021 | Signed as free agent | Sean Kealey | — | St. Louis Cardinals | St. Louis Cardinals signed free agent LHP Sean Kealey to a minor league contract. |
| Jun 15, 2021 | Signed as free agent | Hao-Yu Lee | — | Philadelphia Phillies | Philadelphia Phillies signed free agent IF Hao Yu Lee to a minor league contract. |
| Jun 15, 2021 | Trade | Taylor Davis | Baltimore Orioles | Pittsburgh Pirates | Pittsburgh Pirates traded CF Jose Berroa to Baltimore Orioles for 3B Taylor Davis. |
| Jun 15, 2021 | Signed as free agent | David Griffin | — | New York Mets | New York Mets signed free agent RHP David Griffin to a minor league contract. |
| Jun 14, 2021 | Trade | Yacksel Ríos | Seattle Mariners | Boston Red Sox | Seattle Mariners traded RHP Yacksel Rios to Boston Red Sox for cash. |
| Jun 14, 2021 | Signed as free agent | Paul Schwendel | — | St. Louis Cardinals | St. Louis Cardinals signed free agent RHP Paul Schwendel to a minor league contract. |
| Jun 14, 2021 | Trade | Andres Mesa | Seattle Mariners | Texas Rangers | Seattle Mariners traded SS Andres Mesa to Texas Rangers. |
| Jun 14, 2021 | Signed as free agent | Cole Zabowski | — | Colorado Rockies | Colorado Rockies signed free agent 1B Cole Zabowski to a minor league contract. |
| Jun 14, 2021 | Signed as free agent | Tim Susnara | — | Chicago Cubs | Chicago Cubs signed free agent C Tim Susnara to a minor league contract. |
| Jun 14, 2021 | Signed as free agent | Brandon Dickson | — | St. Louis Cardinals | St. Louis Cardinals signed free agent RHP Brandon Dickson to a minor league contract. |
| Jun 14, 2021 | Signed as free agent | Herlyn Pena | — | New York Mets | New York Mets signed free agent RHP Herlyn Pena to a minor league contract. |
| Jun 14, 2021 | Signed as free agent | Yenfri Sosa | — | Kansas City Royals | Kansas City Royals signed free agent LHP Yenfri Sosa to a minor league contract. |
| Jun 14, 2021 | Signed as free agent | Wilfredo Lara | — | New York Mets | New York Mets signed free agent SS Wilfredo Lara to a minor league contract. |
| Jun 13, 2021 | Signed as free agent | Dylan Baker | — | Cincinnati Reds | Cincinnati Reds signed free agent RHP Dylan Baker to a minor league contract. |
| Jun 13, 2021 | Signed as free agent | Adam Lau | — | Minnesota Twins | Minnesota Twins signed free agent RHP Adam Lau to a minor league contract. |
| Jun 13, 2021 | Trade | Lorenzo Quintana | Houston Astros | Miami Marlins | Houston Astros traded C Lorenzo Quintana to Miami Marlins. |
| Jun 13, 2021 | Released | Khris Davis | — | Texas Rangers | Texas Rangers released LF Khris Davis. |
| Jun 13, 2021 | Signed as free agent | Jose Almonte | — | Chicago Cubs | Chicago Cubs signed free agent RHP Jose Almonte to a minor league contract. |
| Jun 13, 2021 | Signed as free agent | Robinson Martínez | — | Miami Marlins | Miami Marlins signed free agent RHP Robinson Martinez to a minor league contract. |
| Jun 13, 2021 | Signed as free agent | Austin Dennis | — | Kansas City Royals | Kansas City Royals signed free agent OF Austin Dennis to a minor league contract. |
| Jun 13, 2021 | Signed as free agent | Kevin Nivar | — | Kansas City Royals | Kansas City Royals signed free agent SS Kevin Nivar to a minor league contract. |
| Jun 13, 2021 | Signed as free agent | Tom Hackimer | — | New York Mets | New York Mets signed free agent RHP Tom Hackimer to a minor league contract. |
| Jun 13, 2021 | Signed as free agent | Grenny Cumana | — | Philadelphia Phillies | Philadelphia Phillies signed free agent SS Grenny Cumana to a minor league contract. |
| Jun 13, 2021 | Signed as free agent | Ramon Pineda | — | Minnesota Twins | Minnesota Twins signed free agent RHP Ramon Pineda to a minor league contract. |
| Jun 13, 2021 | Signed as free agent | Jake Elmore | — | Philadelphia Phillies | Philadelphia Phillies signed free agent SS Jake Elmore to a minor league contract. |
| Jun 13, 2021 | Signed as free agent | Joe Beimel | — | San Diego Padres | San Diego Padres signed free agent LHP Joe Beimel to a minor league contract. |
| Jun 12, 2021 | Trade | Hunter Strickland | Los Angeles Angels | Milwaukee Brewers | Los Angeles Angels traded RHP Hunter Strickland to Milwaukee Brewers for cash. |
| Jun 12, 2021 | Signed as free agent | Cory Thompson | — | St. Louis Cardinals | St. Louis Cardinals signed free agent RHP Cory Thompson to a minor league contract. |
| Jun 12, 2021 | Signed as free agent | Kevin McGovern | — | St. Louis Cardinals | St. Louis Cardinals signed free agent LHP Kevin McGovern to a minor league contract. |
| Jun 12, 2021 | Signed as free agent | Zack Zehner | — | Miami Marlins | Miami Marlins signed free agent LF Zack Zehner to a minor league contract. |
| Jun 12, 2021 | Signed as free agent | Kevin Marnon | — | St. Louis Cardinals | St. Louis Cardinals signed free agent LHP Kevin Marnon to a minor league contract. |
| Jun 12, 2021 | Signed as free agent | Carlos Linarez | — | St. Louis Cardinals | St. Louis Cardinals signed free agent C Carlos Linarez to a minor league contract. |
| Jun 12, 2021 | Signed as free agent | Juan Severino | — | St. Louis Cardinals | St. Louis Cardinals signed free agent RHP Juan Severino to a minor league contract. |
| Jun 12, 2021 | Signed as free agent | Ronny Oliver | — | St. Louis Cardinals | St. Louis Cardinals signed free agent RHP Ronny Oliver to a minor league contract. |
| Jun 12, 2021 | Signed as free agent | Saul Garcia | — | New York Mets | New York Mets signed free agent RHP Saul Garcia to a minor league contract. |
| Jun 11, 2021 | Trade | Matt Wisler | San Francisco Giants | Tampa Bay Rays | Tampa Bay Rays traded LHP Michael Plassmeyer to San Francisco Giants for RHP Matt Wisler and cash. |
| Jun 11, 2021 | Signed as free agent | Mason Melotakis | — | Miami Marlins | Miami Marlins signed free agent LHP Mason Melotakis to a minor league contract. |
| Jun 11, 2021 | Signed as free agent | Logan Morrison | — | Cincinnati Reds | Cincinnati Reds signed free agent 1B Logan Morrison to a minor league contract. |
| Jun 11, 2021 | Signed as free agent | Brooks Hall | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Brooks Hall to a minor league contract. |
| Jun 11, 2021 | Signed as free agent | Leoni De La Cruz | — | Milwaukee Brewers | Milwaukee Brewers signed free agent LHP Leoni De La Cruz to a minor league contract. |
| Jun 10, 2021 | Trade | Jake Bauers | Cleveland Guardians | Seattle Mariners | Cleveland Indians traded DH Jake Bauers to Seattle Mariners for Player To Be Named Later. |
| Jun 10, 2021 | Signed as free agent | Jason García | — | Minnesota Twins | Minnesota Twins signed free agent RHP Jason Garcia to a minor league contract. |
| Jun 10, 2021 | Signed as free agent | Oscar Araba | — | Miami Marlins | Miami Marlins signed free agent RHP Oscar Araba to a minor league contract. |
| Jun 9, 2021 | Signed as free agent | Michael Mariot | — | Cincinnati Reds | Cincinnati Reds signed free agent RHP Michael Mariot to a minor league contract. |
| Jun 9, 2021 | Signed as free agent | Eric Stout | — | Miami Marlins | Miami Marlins signed free agent LHP Eric Stout to a minor league contract. |
| Jun 9, 2021 | Signed as free agent | Logan Gillaspie | — | Baltimore Orioles | Baltimore Orioles signed free agent RHP Logan Gillaspie to a minor league contract. |
| Jun 9, 2021 | Signed as free agent | Jayvien Sandridge | — | Cincinnati Reds | Cincinnati Reds signed free agent LHP Jayvien Sandridge to a minor league contract. |
| Jun 8, 2021 | Signed as free agent | César Puello | — | New York Mets | New York Mets signed free agent RF Cesar Puello to a minor league contract. |
| Jun 8, 2021 | Signed as free agent | Jose Aular | — | New York Mets | New York Mets signed free agent C Jose Aular to a minor league contract. |
| Jun 7, 2021 | Signed as free agent | Bobby Milacki | — | Minnesota Twins | Minnesota Twins signed free agent RHP Bobby Milacki to a minor league contract. |
| Jun 7, 2021 | Signed as free agent | Carlos Sepulveda | — | Chicago Cubs | Chicago Cubs signed free agent 2B Carlos Sepulveda to a minor league contract. |
| Jun 7, 2021 | Signed as free agent | Braxton Lee | — | Cincinnati Reds | Cincinnati Reds signed free agent LF Braxton Lee to a minor league contract. |
| Jun 7, 2021 | Signed as free agent | Edgar Alfonso | — | Los Angeles Angels | Los Angeles Angels signed free agent SS Edgar Alfonso to a minor league contract. |
| Jun 7, 2021 | Signed as free agent | Cristian Garcia | — | Los Angeles Angels | Los Angeles Angels signed free agent 3B Cristian Garcia to a minor league contract. |
| Jun 7, 2021 | Signed as free agent | Cole Bellair | — | Minnesota Twins | Minnesota Twins signed free agent RHP Cole Bellair to a minor league contract. |
| Jun 7, 2021 | Signed as free agent | Dameivi Tineo | — | Miami Marlins | Miami Marlins signed free agent LHP Dameivi Tineo to a minor league contract. |
| Jun 7, 2021 | Signed as free agent | Yeudi Lora | — | New York Mets | New York Mets signed free agent RHP Yeudi Lora to a minor league contract. |
| Jun 7, 2021 | Signed as free agent | Haminton Mendez | — | Los Angeles Angels | Los Angeles Angels signed free agent RHP Haminton Mendez to a minor league contract. |
| Jun 7, 2021 | Signed as free agent | Jhancarlos Lara | — | Atlanta Braves | Atlanta Braves signed free agent RHP Jhancarlos Lara to a minor league contract. |
| Jun 6, 2021 | Signed as free agent | Adrian De Los Santos | — | San Diego Padres | San Diego Padres signed free agent RHP Adrian De Los Santos to a minor league contract. |
| Jun 5, 2021 | Trade | Bruce Maxwell | New York Mets | San Francisco Giants | New York Mets traded C Bruce Maxwell to San Francisco Giants. |
| Jun 5, 2021 | Signed as free agent | Jesús Liranzo | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Jesus Liranzo to a minor league contract. |
| Jun 4, 2021 | Signed as free agent | Josh Rogers | — | Washington Nationals | Washington Nationals signed free agent LHP Josh Rogers to a minor league contract. |
| Jun 4, 2021 | Trade | Ty Tice | Toronto Blue Jays | Atlanta Braves | Toronto Blue Jays traded RHP Ty Tice to Atlanta Braves for cash. |
| Jun 4, 2021 | Signed as free agent | Jake Reed | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Jake Reed to a minor league contract. |
| Jun 4, 2021 | Trade | Yacksel Ríos | Tampa Bay Rays | Seattle Mariners | Tampa Bay Rays traded RHP Yacksel Rios to Seattle Mariners for cash. |
| Jun 4, 2021 | Trade | Luis De La Rosa | Kansas City Royals | Boston Red Sox | Kansas City Royals traded RHP Grant Gambrell and RHP Luis De La Rosa to Boston Red Sox. |
| Jun 4, 2021 | Trade | Freddy Valdez | New York Mets | Boston Red Sox | New York Mets traded RF Freddy Valdez to Boston Red Sox. |
| Jun 4, 2021 | Signed as free agent | Cesar Rodriguez | — | Atlanta Braves | Atlanta Braves signed free agent C Cesar Rodriguez to a minor league contract. |
| Jun 4, 2021 | Signed as free agent | Anthony Perez | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Anthony Perez to a minor league contract. |
| Jun 4, 2021 | Signed as free agent | Arielbi Gonzalez | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Arielbi Gonzalez to a minor league contract. |
| Jun 4, 2021 | Signed as free agent | Leosdany Molina | — | Houston Astros | Houston Astros signed free agent IF Leosdany Molina to a minor league contract. |
| Jun 3, 2021 | Trade | Tyler Jones | Miami Marlins | Arizona Diamondbacks | Miami Marlins traded RHP Tyler Jones to Arizona Diamondbacks. |
| Jun 3, 2021 | Signed as free agent | Johnny Barbato | — | Toronto Blue Jays | Toronto Blue Jays signed free agent RHP Johnny Barbato to a minor league contract. |
| Jun 3, 2021 | Signed as free agent | Matt Mullenbach | — | Minnesota Twins | Minnesota Twins signed free agent RHP Matt Mullenbach to a minor league contract. |
| Jun 3, 2021 | Signed as free agent | Zach Vincej | — | Seattle Mariners | Seattle Mariners signed free agent SS Zach Vincej to a minor league contract. |
| Jun 3, 2021 | Signed as free agent | Samuel Perez | — | Minnesota Twins | Minnesota Twins signed free agent LHP Samuel Perez to a minor league contract. |
| Jun 2, 2021 | Trade | Ildemaro Vargas | Pittsburgh Pirates | Arizona Diamondbacks | Pittsburgh Pirates traded 2B Ildemaro Vargas to Arizona Diamondbacks for cash. |
| Jun 2, 2021 | Signed as free agent | Steven Moyers | — | Seattle Mariners | Seattle Mariners signed free agent LHP Steven Moyers to a minor league contract. |
| Jun 2, 2021 | Signed as free agent | Cheslor Cuthbert | — | New York Mets | New York Mets signed free agent 3B Cheslor Cuthbert to a minor league contract. |
| Jun 2, 2021 | Signed as free agent | Elliot Johnstone | — | New York Mets | New York Mets signed free agent RHP Elliot Johnstone to a minor league contract. |
| Jun 1, 2021 | Signed as free agent | Galli Cribbs Jr. | — | Miami Marlins | Miami Marlins signed free agent SS Galli Cribbs Jr. to a minor league contract. |
| Jun 1, 2021 | Signed as free agent | Wade LeBlanc | — | Texas Rangers | Texas Rangers signed free agent LHP Wade LeBlanc to a minor league contract. |
| Jun 1, 2021 | Signed as free agent | Justin Twine | — | Miami Marlins | Miami Marlins signed free agent SS Justin Twine to a minor league contract. |
| Jun 1, 2021 | Trade | Connor Cannon | San Francisco Giants | New York Yankees | San Francisco Giants traded 1B Connor Cannon to New York Yankees. |
| Jun 1, 2021 | Signed as free agent | Jose Chacin | — | New York Mets | New York Mets signed free agent RHP Jose Chacin to a minor league contract. |
| Jun 1, 2021 | Signed as free agent | Zaquiel Puentes | — | Minnesota Twins | Minnesota Twins signed free agent RHP Zaquiel Puentes to a minor league contract. |
| Jun 1, 2021 | Signed as free agent | Kelby Tomlinson | — | Colorado Rockies | Colorado Rockies signed free agent 2B Kelby Tomlinson to a minor league contract. |
| Jun 1, 2021 | Signed as free agent | Nick Anderson | — | Minnesota Twins | Minnesota Twins signed free agent CF Nick Anderson to a minor league contract. |
| Jun 1, 2021 | Signed as free agent | Vidal Nuño | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent LHP Vidal Nuno to a minor league contract. |
| May 31, 2021 | Trade | Sam Delaplane | Seattle Mariners | San Francisco Giants | Seattle Mariners traded RHP Sam Delaplane to San Francisco Giants for cash. |
| May 31, 2021 | Released | Shelby Miller | — | Chicago Cubs | Chicago Cubs released RHP Shelby Miller. |
| May 31, 2021 | Signed as free agent | Hayden Shenefield | — | Cincinnati Reds | Cincinnati Reds signed free agent RHP Hayden Shenefield to a minor league contract. |
| May 31, 2021 | Signed as free agent | Remy Cesar | — | Texas Rangers | Texas Rangers signed free agent RHP Remy Cesar to a minor league contract. |
| May 31, 2021 | Signed as free agent | Luis Germán | — | Washington Nationals | Washington Nationals signed free agent RHP Luis German to a minor league contract. |
| May 31, 2021 | Signed as free agent | Edinson Duran | — | New York Yankees | New York Yankees signed free agent C Edinson Duran to a minor league contract. |
| May 30, 2021 | Signed as free agent | Nick Belzer | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Nick Belzer to a minor league contract. |
| May 30, 2021 | Signed as free agent | Heath Fillmyer | — | Cleveland Guardians | Cleveland Indians signed free agent RHP Heath Fillmyer to a minor league contract. |
| May 30, 2021 | Signed as free agent | Kevin Folman | — | Chicago White Sox | Chicago White Sox signed free agent RHP Kevin Folman to a minor league contract. |
| May 30, 2021 | Signed as free agent | Gustavo Polanco | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent C Gustavo Polanco to a minor league contract. |
| May 30, 2021 | Signed as free agent | Bret Boswell | — | Colorado Rockies | Colorado Rockies signed free agent SS Bret Boswell to a minor league contract. |
| May 30, 2021 | Signed as free agent | Tyler Pike | — | St. Louis Cardinals | St. Louis Cardinals signed free agent LHP Tyler Pike to a minor league contract. |
| May 30, 2021 | Signed as free agent | Jared Hoying | — | Toronto Blue Jays | Toronto Blue Jays signed free agent LF Jared Hoying to a minor league contract. |
| May 30, 2021 | Signed as free agent | Luis Gonzalez | — | New York Mets | New York Mets signed free agent SS Luis Gonzalez to a minor league contract. |
| May 29, 2021 | Signed as free agent | Corban Joseph | — | Washington Nationals | Washington Nationals signed free agent 1B Corban Joseph to a minor league contract. |
| May 29, 2021 | Signed as free agent | Trace Loehr | — | Texas Rangers | Texas Rangers signed free agent SS Trace Loehr to a minor league contract. |
| May 29, 2021 | Signed as free agent | Dee Strange-Gordon | — | Chicago Cubs | Chicago Cubs signed free agent 2B Dee Strange-Gordon to a minor league contract. |
| May 29, 2021 | Signed as free agent | Malcolm Van Buren | — | Atlanta Braves | Atlanta Braves signed free agent RHP Malcolm Van Buren to a minor league contract. |
| May 29, 2021 | Signed as free agent | Cam Beauchamp | — | Chicago White Sox | Chicago White Sox signed free agent LHP Cam Beauchamp to a minor league contract. |
| May 29, 2021 | Signed as free agent | Eider Machuca | — | Minnesota Twins | Minnesota Twins signed free agent RHP Eider Machuca to a minor league contract. |
| May 28, 2021 | Signed as free agent | Tyler Ladendorf | — | Chicago Cubs | Chicago Cubs signed free agent 2B Tyler Ladendorf to a minor league contract. |
| May 28, 2021 | Signed as free agent | Jheremy Vicente | — | Kansas City Royals | Kansas City Royals signed free agent RHP Jheremy Vicente to a minor league contract. |
| May 27, 2021 | Signed as free agent | BJ Boyd | — | Minnesota Twins | Minnesota Twins signed free agent LF BJ Boyd to a minor league contract. |
| May 26, 2021 | Trade | Pedro Quintana | New York Mets | Milwaukee Brewers | New York Mets traded LHP Pedro Quintana to Milwaukee Brewers for LF Billy McKinney. |
| May 26, 2021 | Released | Jason Adam | — | Chicago Cubs | Chicago Cubs released RHP Jason Adam. |
| May 26, 2021 | Signed as free agent | Bryan Brickhouse | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Bryan Brickhouse to a minor league contract. |
| May 26, 2021 | Signed as free agent | Taylor Ahearn | — | Los Angeles Angels | Los Angeles Angels signed free agent RHP Taylor Ahearn to a minor league contract. |
| May 26, 2021 | Signed as free agent | Brian Schlitter | — | Seattle Mariners | Seattle Mariners signed free agent RHP Brian Schlitter to a minor league contract. |
| May 26, 2021 | Signed as free agent | Sean Mellen | — | Toronto Blue Jays | Toronto Blue Jays signed free agent LHP Sean Mellen to a minor league contract. |
| May 26, 2021 | Signed as free agent | Seamus Curran | — | San Diego Padres | San Diego Padres signed free agent 1B Seamus Curran to a minor league contract. |
| May 25, 2021 | Signed as free agent | Kevin Herget | — | Cleveland Guardians | Cleveland Indians signed free agent RHP Kevin Herget to a minor league contract. |
| May 25, 2021 | Signed as free agent | Jorge Bonifacio | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RF Jorge Bonifacio to a minor league contract. |
| May 25, 2021 | Signed as free agent | Jon Olczak | — | Houston Astros | Houston Astros signed free agent RHP Jon Olczak to a minor league contract. |
| May 24, 2021 | Released | Bret Boswell | — | Colorado Rockies | Colorado Rockies released SS Bret Boswell. |
| May 24, 2021 | Signed as free agent | Ramiro Altagracia | — | New York Yankees | New York Yankees signed free agent OF Ramiro Altagracia to a minor league contract. |
| May 24, 2021 | Signed as free agent | Willy Montero | — | New York Yankees | New York Yankees signed free agent CF Willy Montero to a minor league contract. |
| May 24, 2021 | Signed as free agent | L.A. Woodard | — | Colorado Rockies | Colorado Rockies signed free agent SS L.A. Woodard to a minor league contract. |
| May 24, 2021 | Signed as free agent | Jordan Milbrath | — | Minnesota Twins | Minnesota Twins signed free agent RHP Jordan Milbrath to a minor league contract. |
| May 22, 2021 | Trade | Domingo Tapia | Seattle Mariners | Kansas City Royals | Seattle Mariners traded RHP Domingo Tapia to Kansas City Royals for cash. |
| May 22, 2021 | Signed as free agent | Zack Weiss | — | Seattle Mariners | Seattle Mariners signed free agent RHP Zack Weiss to a minor league contract. |
| May 22, 2021 | Trade | Yoan López | Arizona Diamondbacks | Atlanta Braves | Arizona Diamondbacks traded RHP Yoan Lopez to Atlanta Braves for CF Deivi Estrada. |
| May 22, 2021 | Signed | Noé Ramirez | — | Arizona Diamondbacks | Arizona Diamondbacks signed RHP Noe Ramirez. |
| May 22, 2021 | Signed | Nick Gardewine | — | Arizona Diamondbacks | Arizona Diamondbacks signed RHP Nick Gardewine. |
| May 22, 2021 | Signed as free agent | Fraudy Maldonado | — | Milwaukee Brewers | Milwaukee Brewers signed free agent LHP Fraudy Maldonado to a minor league contract. |
| May 22, 2021 | Signed as free agent | Jarod Wright | — | Chicago Cubs | Chicago Cubs signed free agent Jarod Wright to a minor league contract. |
| May 21, 2021 | Trade | Trevor Richards | Tampa Bay Rays | Milwaukee Brewers | Tampa Bay Rays traded SS Willy Adames and RHP Trevor Richards to Milwaukee Brewers for RHP J.P. Feyereisen and RHP Drew Rasmussen. |
| May 21, 2021 | Signed as free agent | Williams Jerez | — | Seattle Mariners | Seattle Mariners signed free agent LHP Williams Jerez to a minor league contract. |
| May 21, 2021 | Signed as free agent | Zack Kone | — | Miami Marlins | Miami Marlins signed free agent SS Zack Kone to a minor league contract. |
| May 20, 2021 | Signed as free agent | Bryce Hutchinson | — | Chicago White Sox | Chicago White Sox signed free agent RHP Bryce Hutchinson to a minor league contract. |
| May 20, 2021 | Signed as free agent | Ryan Williamson | — | Chicago White Sox | Chicago White Sox signed free agent LHP Ryan Williamson to a minor league contract. |
| May 20, 2021 | Signed as free agent | Gerson Calzadilla | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Gerson Calzadilla to a minor league contract. |
| May 19, 2021 | Trade | Kevan Smith | Tampa Bay Rays | Atlanta Braves | Tampa Bay Rays traded C Kevan Smith to Atlanta Braves for cash. |
| May 19, 2021 | Signed as free agent | E.P. Reese | — | Chicago White Sox | Chicago White Sox signed free agent CF E.P. Reese to a minor league contract. |
| May 19, 2021 | Signed as free agent | Heylin Taveras | — | Chicago White Sox | Chicago White Sox signed free agent RHP Heylin Taveras to a minor league contract. |
| May 19, 2021 | Signed as free agent | Kennie Taylor | — | Seattle Mariners | Seattle Mariners signed free agent CF Kennie Taylor to a minor league contract. |
| May 19, 2021 | Signed as free agent | Tyler Danish | — | Los Angeles Angels | Los Angeles Angels signed free agent RHP Tyler Danish to a minor league contract. |
| May 19, 2021 | Signed as free agent | Dario Agrazal | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Dario Agrazal to a minor league contract. |
| May 19, 2021 | Signed as free agent | Henry Ramos | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RF Henry Ramos to a minor league contract. |
| May 19, 2021 | Signed as free agent | Yelinson Pena | — | Miami Marlins | Miami Marlins signed free agent SS Yelinson Pena to a minor league contract. |
| May 19, 2021 | Signed as free agent | Sal Romano | — | New York Yankees | New York Yankees signed free agent RHP Sal Romano to a minor league contract. |
| May 18, 2021 | Trade | Sean Poppen | Pittsburgh Pirates | Tampa Bay Rays | Pittsburgh Pirates traded RHP Sean Poppen to Tampa Bay Rays for cash. |
| May 18, 2021 | Trade | Cameron Maybin | Chicago Cubs | New York Mets | Chicago Cubs traded CF Cameron Maybin to New York Mets for cash. |
| May 18, 2021 | Signed as free agent | Tim Peterson | — | Los Angeles Angels | Los Angeles Angels signed free agent RHP Tim Peterson to a minor league contract. |
| May 18, 2021 | Signed as free agent | Mikey Reynolds | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent 2B Mikey Reynolds to a minor league contract. |
| May 18, 2021 | Signed as free agent | Carlos Luna | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Carlos Luna to a minor league contract. |
| May 18, 2021 | Signed as free agent | Akeem Bostick | — | New York Mets | New York Mets signed free agent RHP Akeem Bostick to a minor league contract. |
| May 18, 2021 | Signed as free agent | Franklin Pérez | — | Detroit Tigers | Detroit Tigers signed free agent RHP Franklin Perez to a minor league contract. |
| May 18, 2021 | Signed as free agent | Raul Guzman | — | Chicago Cubs | Chicago Cubs signed free agent OF Raul Guzman to a minor league contract. |
| May 18, 2021 | Signed as free agent | Carlos Garcia | — | Chicago Cubs | Chicago Cubs signed free agent LHP Carlos Garcia to a minor league contract. |
| May 18, 2021 | Signed as free agent | Tomy Sanchez | — | Chicago Cubs | Chicago Cubs signed free agent RHP Tomy Sanchez to a minor league contract. |
| May 18, 2021 | Signed as free agent | Starlyn Pichardo | — | Chicago Cubs | Chicago Cubs signed free agent RHP Starlyn Pichardo to a minor league contract. |
| May 17, 2021 | Signed as free agent | Albert Pujols | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent 1B Albert Pujols. |
| May 17, 2021 | Signed as free agent | Anthony Lepre | — | Seattle Mariners | Seattle Mariners signed free agent C Anthony Lepre to a minor league contract. |
| May 17, 2021 | Signed as free agent | Domingo Mejia | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Domingo Mejia to a minor league contract. |
| May 17, 2021 | Signed as free agent | Albert Pujols | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent 1B Albert Pujols. |
| May 17, 2021 | Signed as free agent | Albert Pujols | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent 1B Albert Pujols. |
| May 16, 2021 | Trade | Wyatt Mathisen | Arizona Diamondbacks | Tampa Bay Rays | Arizona Diamondbacks traded 3B Wyatt Mathisen to Tampa Bay Rays for cash. |
| May 16, 2021 | Signed as free agent | Adam Conley | — | Tampa Bay Rays | Tampa Bay Rays signed free agent LHP Adam Conley to a minor league contract. |
| May 16, 2021 | Signed as free agent | Daniel Procopio | — | Houston Astros | Houston Astros signed free agent RHP Daniel Procopio to a minor league contract. |
| May 16, 2021 | Signed as free agent | Jonathan Lucroy | — | Atlanta Braves | Atlanta Braves signed free agent C Jonathan Lucroy to a minor league contract. |
| May 15, 2021 | Trade | Hunter Strickland | Tampa Bay Rays | Los Angeles Angels | Tampa Bay Rays traded RHP Hunter Strickland to Los Angeles Angels for cash. |
| May 15, 2021 | Trade | Yoshi Tsutsugo | Tampa Bay Rays | Los Angeles Dodgers | Tampa Bay Rays traded LF Yoshi Tsutsugo to Los Angeles Dodgers for Player To Be Named Later. |
| May 15, 2021 | Signed as free agent | Danny Sinatro | — | Chicago White Sox | Chicago White Sox signed free agent CF Danny Sinatro to a minor league contract. |
| May 15, 2021 | Signed as free agent | Jeremiah Burks | — | Chicago White Sox | Chicago White Sox signed free agent SS Jeremiah Burks to a minor league contract. |
| May 15, 2021 | Signed as free agent | Allen Facundo | — | New York Yankees | New York Yankees signed free agent LHP Allen Facundo to a minor league contract. |
| May 14, 2021 | Signed as free agent | Joseph Fernando | — | Atlanta Braves | Atlanta Braves signed free agent SS Joseph Fernando to a minor league contract. |
| May 14, 2021 | Signed as free agent | Nate Jones | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Nate Jones to a minor league contract. |
| May 14, 2021 | Signed | Tyler Suellentrop | — | Chicago Cubs | Chicago Cubs signed RHP Tyler Suellentrop. |
| May 14, 2021 | Signed | Carl Edwards Jr. | — | Toronto Blue Jays | Toronto Blue Jays signed RHP Carl Edwards Jr.. |
| May 14, 2021 | Signed as free agent | Jesus Valles | — | Chicago White Sox | Chicago White Sox signed free agent RHP Jesus Valles to a minor league contract. |
| May 14, 2021 | Signed as free agent | Anthony Swarzak | — | Kansas City Royals | Kansas City Royals signed free agent RHP Anthony Swarzak to a minor league contract. |
| May 14, 2021 | Signed as free agent | Luc Rennie | — | New York Mets | New York Mets signed free agent RHP Luc Rennie to a minor league contract. |
| May 14, 2021 | Signed as free agent | A.J. Schugel | — | New York Mets | New York Mets signed free agent RHP A.J. Schugel to a minor league contract. |
| May 14, 2021 | Signed as free agent | Alexis Pantoja | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent SS Alexis Pantoja to a minor league contract. |
| May 14, 2021 | Signed as free agent | Kevin Aparicio | — | New York Yankees | New York Yankees signed free agent RHP Kevin Aparicio to a minor league contract. |
| May 13, 2021 | Signed as free agent | David Huff | — | Seattle Mariners | Seattle Mariners signed free agent LHP David Huff to a minor league contract. |
| May 13, 2021 | Signed as free agent | Daniel Descalso | — | Minnesota Twins | Minnesota Twins signed free agent 2B Daniel Descalso to a minor league contract. |
| May 13, 2021 | Released | Albert Pujols | — | Los Angeles Angels | Los Angeles Angels released 1B Albert Pujols. |
| May 13, 2021 | Signed as free agent | Josh Lucas | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Josh Lucas to a minor league contract. |
| May 13, 2021 | Signed as free agent | Conor Fisk | — | Colorado Rockies | Colorado Rockies signed free agent RHP Conor Fisk to a minor league contract. |
| May 13, 2021 | Signed as free agent | Jake Buchanan | — | Los Angeles Angels | Los Angeles Angels signed free agent RHP Jake Buchanan to a minor league contract. |
| May 13, 2021 | Signed as free agent | Kent Hasler | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Kent Hasler to a minor league contract. |
| May 13, 2021 | Signed as free agent | Carlos Arroyo | — | Miami Marlins | Miami Marlins signed free agent 2B Carlos Arroyo to a minor league contract. |
| May 12, 2021 | Released | Franklin Pérez | — | Detroit Tigers | Detroit Tigers released RHP Franklin Perez. |
| May 12, 2021 | Signed as free agent | Brandon Koch | — | Minnesota Twins | Minnesota Twins signed free agent RHP Brandon Koch to a minor league contract. |
| May 12, 2021 | Signed as free agent | Sherman Johnson | — | Minnesota Twins | Minnesota Twins signed free agent 2B Sherman Johnson to a minor league contract. |
| May 12, 2021 | Signed as free agent | Mitch Walding | — | Los Angeles Angels | Los Angeles Angels signed free agent 3B Mitch Walding to a minor league contract. |
| May 12, 2021 | Signed as free agent | Eric Campbell | — | Seattle Mariners | Seattle Mariners signed free agent 3B Eric Campbell to a minor league contract. |
| May 12, 2021 | Signed as free agent | Tyler Herb | — | Seattle Mariners | Seattle Mariners signed free agent RHP Tyler Herb to a minor league contract. |
| May 12, 2021 | Signed as free agent | Clint Coulter | — | St. Louis Cardinals | St. Louis Cardinals signed free agent RF Clint Coulter to a minor league contract. |
| May 12, 2021 | Signed as free agent | Gavin Cecchini | — | Los Angeles Angels | Los Angeles Angels signed free agent SS Gavin Cecchini to a minor league contract. |
| May 12, 2021 | Signed as free agent | Jenier Fernandez | — | Washington Nationals | Washington Nationals signed free agent 3B Jenier Fernandez to a minor league contract. |
| May 12, 2021 | Signed as free agent | Destin Hood | — | Washington Nationals | Washington Nationals signed free agent LF Destin Hood to a minor league contract. |
| May 12, 2021 | Signed as free agent | Manuel De La Rosa | — | Los Angeles Angels | Los Angeles Angels signed free agent RHP Manuel De La Rosa to a minor league contract. |
| May 12, 2021 | Signed as free agent | Jorge Ruiz | — | Los Angeles Angels | Los Angeles Angels signed free agent OF Jorge Ruiz to a minor league contract. |
| May 12, 2021 | Signed as free agent | Wilfredo Cordero | — | Texas Rangers | Texas Rangers signed free agent RHP Wilfredo Cordero to a minor league contract. |
| May 11, 2021 | Trade | Trayce Thompson | Arizona Diamondbacks | Chicago Cubs | Arizona Diamondbacks traded RF Trayce Thompson to Chicago Cubs. |
| May 11, 2021 | Signed | Austin Rei | — | Arizona Diamondbacks | Arizona Diamondbacks signed C Austin Rei. |
| May 11, 2021 | Signed as free agent | Jeremy Rhoades | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Jeremy Rhoades to a minor league contract. |
| May 11, 2021 | Signed as free agent | Tanner Roark | — | Atlanta Braves | Atlanta Braves signed free agent RHP Tanner Roark to a minor league contract. |
| May 11, 2021 | Signed as free agent | Justin Washington | — | Minnesota Twins | Minnesota Twins signed free agent CF Justin Washington to a minor league contract. |
| May 11, 2021 | Signed as free agent | Michael Kelly | — | Houston Astros | Houston Astros signed free agent RHP Michael Kelly to a minor league contract. |
| May 11, 2021 | Signed as free agent | Luis Arejula | — | New York Yankees | New York Yankees signed free agent RHP Luis Arejula to a minor league contract. |
| May 11, 2021 | Signed as free agent | Luis Serna | — | New York Yankees | New York Yankees signed free agent RHP Luis Serna to a minor league contract. |
| May 10, 2021 | Released | Nate Jones | — | Atlanta Braves | Atlanta Braves released RHP Nate Jones. |
| May 10, 2021 | Signed as free agent | Dalton Pompey | — | Los Angeles Angels | Los Angeles Angels signed free agent CF Dalton Pompey to a minor league contract. |
| May 10, 2021 | Signed as free agent | Caleb Joseph | — | Seattle Mariners | Seattle Mariners signed free agent C Caleb Joseph to a minor league contract. |
| May 10, 2021 | Signed as free agent | Jagger Rusconi | — | Chicago White Sox | Chicago White Sox signed free agent 2B Jagger Rusconi to a minor league contract. |
| May 10, 2021 | Signed as free agent | Adrian Sampson | — | Chicago Cubs | Chicago Cubs signed free agent RHP Adrian Sampson to a minor league contract. |
| May 10, 2021 | Signed as free agent | Junior Castillo | — | Milwaukee Brewers | Milwaukee Brewers signed free agent LHP Junior Castillo to a minor league contract. |
| May 10, 2021 | Signed as free agent | Gregory Baez | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Gregory Baez to a minor league contract. |
| May 10, 2021 | Signed as free agent | Jose Cardozo | — | Detroit Tigers | Detroit Tigers signed free agent 2B Jose Cardozo to a minor league contract. |
| May 9, 2021 | Signed as free agent | Shane Greene | — | Atlanta Braves | Atlanta Braves signed free agent RHP Shane Greene. |
| May 8, 2021 | Signed as free agent | Ronnie Freeman | — | San Francisco Giants | San Francisco Giants signed free agent C Ronnie Freeman to a minor league contract. |
| May 8, 2021 | Signed as free agent | Deven Marrero | — | Miami Marlins | Miami Marlins signed free agent 3B Deven Marrero to a minor league contract. |
| May 8, 2021 | Signed as free agent | Nick Lovullo | — | Miami Marlins | Miami Marlins signed free agent 2B Nick Lovullo to a minor league contract. |
| May 8, 2021 | Signed as free agent | Yadiel Rivera | — | Houston Astros | Houston Astros signed free agent SS Yadiel Rivera to a minor league contract. |
| May 8, 2021 | Signed as free agent | Gavin Stupienski | — | Kansas City Royals | Kansas City Royals signed free agent C Gavin Stupienski to a minor league contract. |
| May 8, 2021 | Signed as free agent | Jake McSteen | — | Atlanta Braves | Atlanta Braves signed free agent LHP Jake McSteen to a minor league contract. |
| May 7, 2021 | Signed as free agent | Brandon Lawson | — | Houston Astros | Houston Astros signed free agent RHP Brandon Lawson to a minor league contract. |
| May 7, 2021 | Signed as free agent | Hernán Pérez | — | Milwaukee Brewers | Milwaukee Brewers signed free agent 3B Hernan Perez to a minor league contract. |
| May 7, 2021 | Trade | Drew Butera | Texas Rangers | Los Angeles Angels | Texas Rangers traded C Drew Butera to Los Angeles Angels for cash. |
| May 7, 2021 | Signed as free agent | Justin Grimm | — | Seattle Mariners | Seattle Mariners signed free agent RHP Justin Grimm to a minor league contract. |
| May 7, 2021 | Signed as free agent | Brooks Pounders | — | Seattle Mariners | Seattle Mariners signed free agent RHP Brooks Pounders to a minor league contract. |
| May 7, 2021 | Signed as free agent | Andy Otero | — | Milwaukee Brewers | Milwaukee Brewers signed free agent LHP Andy Otero to a minor league contract. |
| May 6, 2021 | Signed as free agent | Nolan Riggs | — | Houston Astros | Houston Astros signed free agent RHP Nolan Riggs to a minor league contract. |
| May 6, 2021 | Signed as free agent | Mitch Longo | — | Milwaukee Brewers | Milwaukee Brewers signed free agent LF Mitch Longo to a minor league contract. |
| May 6, 2021 | Signed as free agent | Brandon Workman | — | Boston Red Sox | Boston Red Sox signed free agent RHP Brandon Workman to a minor league contract. |
| May 6, 2021 | Signed as free agent | Kristin Munroe | — | Los Angeles Angels | Los Angeles Angels signed free agent 3B Kristin Munroe to a minor league contract. |
| May 6, 2021 | Signed as free agent | Keiner Delgado | — | New York Yankees | New York Yankees signed free agent SS Keiner Delgado to a minor league contract. |
| May 6, 2021 | Signed as free agent | Carlos Sanchez | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent CF Carlos Sanchez to a minor league contract. |
| May 6, 2021 | Signed as free agent | Dylan Rheault | — | San Diego Padres | San Diego Padres signed free agent RHP Dylan Rheault to a minor league contract. |
| May 5, 2021 | Trade | Skye Bolt | San Francisco Giants | Athletics | San Francisco Giants traded CF Skye Bolt to Oakland Athletics for cash. |
| May 5, 2021 | Signed as free agent | Brian Goodwin | — | Chicago White Sox | Chicago White Sox signed free agent CF Brian Goodwin to a minor league contract. |
| May 5, 2021 | Signed as free agent | Francisco Arcia | — | Los Angeles Angels | Los Angeles Angels signed free agent C Francisco Arcia to a minor league contract. |
| May 5, 2021 | Signed as free agent | Frank Duncan | — | Colorado Rockies | Colorado Rockies signed free agent RHP Frank Duncan to a minor league contract. |
| May 5, 2021 | Signed as free agent | Dairon De Jesus | — | Athletics | Oakland Athletics signed free agent RHP Dairon De Jesus to a minor league contract. |
| May 5, 2021 | Signed as free agent | D.J. Burt | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent 2B D.J. Burt to a minor league contract. |
| May 5, 2021 | Signed as free agent | Rubén Tejada | — | Philadelphia Phillies | Philadelphia Phillies signed free agent SS Ruben Tejada to a minor league contract. |
| May 4, 2021 | Signed as free agent | Logan Forsythe | — | Milwaukee Brewers | Milwaukee Brewers signed free agent 2B Logan Forsythe to a minor league contract. |
| May 4, 2021 | Signed as free agent | Christian Kelley | — | Milwaukee Brewers | Milwaukee Brewers signed free agent C Christian Kelley to a minor league contract. |
| May 4, 2021 | Signed as free agent | Wade LeBlanc | — | Milwaukee Brewers | Milwaukee Brewers signed free agent LHP Wade LeBlanc to a minor league contract. |
| May 4, 2021 | Signed as free agent | Alcides Escobar | — | Kansas City Royals | Kansas City Royals signed free agent SS Alcides Escobar to a minor league contract. |
| May 4, 2021 | Signed as free agent | Alex Katz | — | Chicago Cubs | Chicago Cubs signed free agent LHP Alex Katz to a minor league contract. |
| May 4, 2021 | Signed as free agent | Austin Krzeminski | — | Chicago Cubs | Chicago Cubs signed free agent RHP Austin Krzeminski to a minor league contract. |
| May 4, 2021 | Signed as free agent | Josue Gonzalez | — | New York Yankees | New York Yankees signed free agent C Josue Gonzalez to a minor league contract. |
| May 4, 2021 | Signed as free agent | Austin Bibens-Dirkx | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Austin Bibens-Dirkx to a minor league contract. |
| May 4, 2021 | Signed as free agent | Henry Lalane | — | New York Yankees | New York Yankees signed free agent LHP Henry Lalane to a minor league contract. |
| May 4, 2021 | Signed as free agent | Fran Visamon | — | New York Yankees | New York Yankees signed free agent RHP Fran Visamon to a minor league contract. |
| May 4, 2021 | Signed as free agent | Ryan Eades | — | Houston Astros | Houston Astros signed free agent RHP Ryan Eades to a minor league contract. |
| May 4, 2021 | Signed as free agent | Hunter Haworth | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Hunter Haworth to a minor league contract. |
| May 4, 2021 | Signed as free agent | Tyler Flowers | — | Atlanta Braves | Atlanta Braves signed free agent C Tyler Flowers to a minor league contract. |
| May 4, 2021 | Signed as free agent | Ryan Dull | — | Seattle Mariners | Seattle Mariners signed free agent RHP Ryan Dull to a minor league contract. |
| May 3, 2021 | Released | Tanner Roark | — | Toronto Blue Jays | Toronto Blue Jays released RHP Tanner Roark. |
| May 3, 2021 | Signed as free agent | Ryan Kellogg | — | Chicago Cubs | Chicago Cubs signed free agent LHP Ryan Kellogg to a minor league contract. |
| May 3, 2021 | Signed as free agent | Ricky Aracena | — | Miami Marlins | Miami Marlins signed free agent SS Ricky Aracena to a minor league contract. |
| May 3, 2021 | Signed as free agent | Matt Lipka | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent CF Matt Lipka to a minor league contract. |
| May 3, 2021 | Signed as free agent | Mitchell Osnowitz | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Mitchell Osnowitz to a minor league contract. |
| May 3, 2021 | Signed as free agent | Micah Kaczor | — | Colorado Rockies | Colorado Rockies signed free agent RHP Micah Kaczor to a minor league contract. |
| May 3, 2021 | Signed as free agent | Matt Pierpont | — | Seattle Mariners | Seattle Mariners signed free agent RHP Matt Pierpont to a minor league contract. |
| May 2, 2021 | Trade | Paxton Schultz | Milwaukee Brewers | Toronto Blue Jays | Milwaukee Brewers traded RHP Paxton Schultz to Toronto Blue Jays. |
| May 2, 2021 | Trade | Jacob Nottingham | Seattle Mariners | Milwaukee Brewers | Seattle Mariners traded C Jacob Nottingham to Milwaukee Brewers for cash. |
| May 1, 2021 | Signed as free agent | Aaron Wilkerson | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Aaron Wilkerson to a minor league contract. |
| May 1, 2021 | Signed as free agent | Cam Bedrosian | — | Athletics | Oakland Athletics signed free agent RHP Cam Bedrosian to a minor league contract. |
| May 1, 2021 | Signed as free agent | Christian Bethancourt | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent C Christian Bethancourt to a minor league contract. |
| May 1, 2021 | Signed as free agent | Zach Muckenhirn | — | Chicago White Sox | Chicago White Sox signed free agent LHP Zach Muckenhirn to a minor league contract. |
| May 1, 2021 | Signed as free agent | Brad Brach | — | Cincinnati Reds | Cincinnati Reds signed free agent RHP Brad Brach to a minor league contract. |
| May 1, 2021 | Signed as free agent | Kevin Quackenbush | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Kevin Quackenbush to a minor league contract. |
| May 1, 2021 | Signed as free agent | Rob Whalen | — | Minnesota Twins | Minnesota Twins signed free agent RHP Rob Whalen to a minor league contract. |
| May 1, 2021 | Signed as free agent | Jesus Tovar | — | Minnesota Twins | Minnesota Twins signed free agent RHP Jesus Tovar to a minor league contract. |
| May 1, 2021 | Signed as free agent | Jose Marcano | — | New York Mets | New York Mets signed free agent C Jose Marcano to a minor league contract. |
| May 1, 2021 | Signed as free agent | Junior Marino | — | Minnesota Twins | Minnesota Twins signed free agent RHP Junior Marino to a minor league contract. |
| Apr 30, 2021 | Signed as free agent | Tim Adleman | — | Cincinnati Reds | Cincinnati Reds signed free agent RHP Tim Adleman to a minor league contract. |
| Apr 30, 2021 | Released | Brandon Workman | — | Chicago Cubs | Chicago Cubs released RHP Brandon Workman. |
| Apr 30, 2021 | Signed as free agent | Tyler Friis | — | Milwaukee Brewers | Milwaukee Brewers signed free agent 2B Tyler Friis to a minor league contract. |
| Apr 30, 2021 | Signed as free agent | Bryan Hernandez | — | Los Angeles Angels | Los Angeles Angels signed free agent RHP Bryan Hernandez to a minor league contract. |
| Apr 30, 2021 | Signed as free agent | Johan Figuereo | — | Houston Astros | Houston Astros signed free agent RHP Johan Figuereo to a minor league contract. |
| Apr 30, 2021 | Trade | Corey Stone | Texas Rangers | Chicago White Sox | Texas Rangers traded LHP Corey Stone to Chicago White Sox. |
| Apr 29, 2021 | Signed as free agent | Rodrigo Vigil | — | Toronto Blue Jays | Toronto Blue Jays signed free agent C Rodrigo Vigil to a minor league contract. |
| Apr 29, 2021 | Signed as free agent | Juan Mota | — | Los Angeles Angels | Los Angeles Angels signed free agent 3B Juan Mota to a minor league contract. |
| Apr 29, 2021 | Signed as free agent | Jefry Yan | — | Miami Marlins | Miami Marlins signed free agent LHP Jefry Yan to a minor league contract. |
| Apr 28, 2021 | Signed as free agent | Trevor Kelley | — | Atlanta Braves | Atlanta Braves signed free agent RHP Trevor Kelley to a minor league contract. |
| Apr 28, 2021 | Signed as free agent | Christian Colón | — | Toronto Blue Jays | Toronto Blue Jays signed free agent 2B Christian Colon to a minor league contract. |
| Apr 28, 2021 | Signed as free agent | Dilson Herrera | — | Toronto Blue Jays | Toronto Blue Jays signed free agent 2B Dilson Herrera to a minor league contract. |
| Apr 28, 2021 | Signed as free agent | Chris Nunn | — | Atlanta Braves | Atlanta Braves signed free agent LHP Chris Nunn to a minor league contract. |
| Apr 27, 2021 | Signed as free agent | Mike Shawaryn | — | Kansas City Royals | Kansas City Royals signed free agent RHP Mike Shawaryn to a minor league contract. |
| Apr 27, 2021 | Trade | Wandy Peralta | San Francisco Giants | New York Yankees | New York Yankees traded LF Mike Tauchman to San Francisco Giants for LHP Wandy Peralta and Player To Be Named Later. |
| Apr 27, 2021 | Signed as free agent | Michael Baird | — | Colorado Rockies | Colorado Rockies signed free agent RHP Michael Baird to a minor league contract. |
| Apr 27, 2021 | Signed as free agent | Jared Biddy | — | Colorado Rockies | Colorado Rockies signed free agent RHP Jared Biddy to a minor league contract. |
| Apr 27, 2021 | Signed as free agent | Zachary Hammer | — | Colorado Rockies | Colorado Rockies signed free agent RHP Zachary Hammer to a minor league contract. |
| Apr 27, 2021 | Signed as free agent | Zach Matson | — | Colorado Rockies | Colorado Rockies signed free agent LHP Zach Matson to a minor league contract. |
| Apr 27, 2021 | Signed as free agent | Alex Moore | — | Colorado Rockies | Colorado Rockies signed free agent RHP Alex Moore to a minor league contract. |
| Apr 27, 2021 | Signed as free agent | Bradley Roney | — | New York Mets | New York Mets signed free agent RHP Bradley Roney to a minor league contract. |
| Apr 27, 2021 | Signed as free agent | Josh A. Smith | — | Miami Marlins | Miami Marlins signed free agent RHP Josh A. Smith to a minor league contract. |
| Apr 27, 2021 | Signed as free agent | Jonathan Cheshire | — | Minnesota Twins | Minnesota Twins signed free agent RHP Jonathan Cheshire to a minor league contract. |
| Apr 27, 2021 | Signed as free agent | Harrison Goebel | — | Los Angeles Angels | Los Angeles Angels signed free agent RHP Harrison Goebel to a minor league contract. |
| Apr 26, 2021 | Signed as free agent | Ryan Cordell | — | Philadelphia Phillies | Philadelphia Phillies signed free agent CF Ryan Cordell to a minor league contract. |
| Apr 23, 2021 | Released | Anthony Swarzak | — | Arizona Diamondbacks | Arizona Diamondbacks released RHP Anthony Swarzak. |
| Apr 23, 2021 | Signed as free agent | Matt Koch | — | Cleveland Guardians | Cleveland Indians signed free agent RHP Matt Koch to a minor league contract. |
| Apr 23, 2021 | Signed as free agent | Greg Garcia | — | Philadelphia Phillies | Philadelphia Phillies signed free agent 2B Greg Garcia to a minor league contract. |
| Apr 22, 2021 | Trade | Jeremy Beasley | Arizona Diamondbacks | Toronto Blue Jays | Arizona Diamondbacks traded RHP Jeremy Beasley to Toronto Blue Jays for cash. |
| Apr 22, 2021 | Signed as free agent | Joel Asencio | — | San Diego Padres | San Diego Padres signed free agent RHP Joel Asencio to a minor league contract. |
| Apr 22, 2021 | Signed as free agent | Willy Diaz Vasquez | — | Minnesota Twins | Minnesota Twins signed free agent SS Willy Diaz Vasquez to a minor league contract. |
| Apr 21, 2021 | Signed as free agent | Dee Strange-Gordon | — | Milwaukee Brewers | Milwaukee Brewers signed free agent 2B Dee Strange-Gordon to a minor league contract. |
| Apr 21, 2021 | Signed as free agent | José Rodríguez | — | Atlanta Braves | Atlanta Braves signed free agent RHP Jose Rodriguez to a minor league contract. |
| Apr 21, 2021 | Signed as free agent | Alejandro Salazar | — | Miami Marlins | Miami Marlins signed free agent SS Alejandro Salazar to a minor league contract. |
| Apr 21, 2021 | Signed as free agent | Leobaldo Cabrera | — | Minnesota Twins | Minnesota Twins signed free agent RF Leobaldo Cabrera to a minor league contract. |
| Apr 21, 2021 | Signed as free agent | Will Latcham | — | Atlanta Braves | Atlanta Braves signed free agent RHP Will Latcham to a minor league contract. |
| Apr 21, 2021 | Signed as free agent | Jason Alexander | — | Miami Marlins | Miami Marlins signed free agent RHP Jason Alexander to a minor league contract. |
| Apr 21, 2021 | Signed as free agent | Connor Justus | — | Miami Marlins | Miami Marlins signed free agent SS Connor Justus to a minor league contract. |
| Apr 20, 2021 | Signed as free agent | Noah Gotsis | — | Colorado Rockies | Colorado Rockies signed free agent RHP Noah Gotsis to a minor league contract. |
| Apr 20, 2021 | Signed as free agent | Austin Kitchen | — | Colorado Rockies | Colorado Rockies signed free agent LHP Austin Kitchen to a minor league contract. |
| Apr 19, 2021 | Signed as free agent | Rayan González | — | Colorado Rockies | Colorado Rockies signed free agent RHP Rayan Gonzalez to a minor league contract. |
| Apr 18, 2021 | Signed as free agent | Rob Kaminsky | — | Philadelphia Phillies | Philadelphia Phillies signed free agent LHP Rob Kaminsky to a minor league contract. |
| Apr 18, 2021 | Signed as free agent | José Mesa Jr. | — | Miami Marlins | Miami Marlins signed free agent RHP Jose Mesa Jr. to a minor league contract. |
| Apr 18, 2021 | Signed as free agent | Brayan Diaz | — | Seattle Mariners | Seattle Mariners signed free agent RHP Brayan Diaz to a minor league contract. |
| Apr 17, 2021 | Trade | Eduardo Herrera | Arizona Diamondbacks | Kansas City Royals | Kansas City Royals traded CF Nick Heath to Arizona Diamondbacks for RHP Eduardo Herrera. |
| Apr 17, 2021 | Signed as free agent | Jesse Chavez | — | Atlanta Braves | Atlanta Braves signed free agent RHP Jesse Chavez to a minor league contract. |
| Apr 17, 2021 | Signed as free agent | Gabriel Silva | — | Kansas City Royals | Kansas City Royals signed free agent C Gabriel Silva to a minor league contract. |
| Apr 17, 2021 | Signed as free agent | Wilker Ruiz | — | Colorado Rockies | Colorado Rockies signed free agent LHP Wilker Ruiz to a minor league contract. |
| Apr 16, 2021 | Signed as free agent | Daniel Palka | — | Washington Nationals | Washington Nationals signed free agent LF Daniel Palka to a minor league contract. |
| Apr 15, 2021 | Signed as free agent | Chris Rusin | — | Colorado Rockies | Colorado Rockies signed free agent LHP Chris Rusin to a minor league contract. |
| Apr 15, 2021 | Signed as free agent | Juan Centeno | — | Detroit Tigers | Detroit Tigers signed free agent C Juan Centeno to a minor league contract. |
| Apr 15, 2021 | Signed as free agent | Mason Williams | — | New York Mets | New York Mets signed free agent CF Mason Williams to a minor league contract. |
| Apr 15, 2021 | Signed as free agent | Dylan Lee | — | Atlanta Braves | Atlanta Braves signed free agent LHP Dylan Lee to a minor league contract. |
| Apr 15, 2021 | Signed as free agent | Jesus Lopez | — | Boston Red Sox | Boston Red Sox signed free agent RHP Jesus Lopez to a minor league contract. |
| Apr 15, 2021 | Signed as free agent | Yokelvin Reyes | — | Los Angeles Angels | Los Angeles Angels signed free agent LHP Yokelvin Reyes to a minor league contract. |
| Apr 15, 2021 | Signed as free agent | Kevison Hernandez | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent RHP Kevison Hernandez to a minor league contract. |
| Apr 14, 2021 | Signed as free agent | René Rivera | — | Cleveland Guardians | Cleveland Indians signed free agent C Rene Rivera. |
| Apr 14, 2021 | Signed as free agent | Vincenzo Aiello | — | Chicago White Sox | Chicago White Sox signed free agent RHP Vincenzo Aiello to a minor league contract. |
| Apr 14, 2021 | Signed as free agent | Gabriel Rodriguez | — | Chicago White Sox | Chicago White Sox signed free agent RHP Gabriel Rodriguez to a minor league contract. |
| Apr 14, 2021 | Signed as free agent | Luis Pino | — | St. Louis Cardinals | St. Louis Cardinals signed free agent CF Luis Pino to a minor league contract. |
| Apr 13, 2021 | Signed as free agent | Franyer Duarte | — | Miami Marlins | Miami Marlins signed free agent RHP Franyer Duarte to a minor league contract. |
| Apr 12, 2021 | Signed as free agent | Iván Nova | — | Colorado Rockies | Colorado Rockies signed free agent P Ivan Nova. |
| Apr 12, 2021 | Signed as free agent | Josh Reddick | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RF Josh Reddick. |
| Apr 12, 2021 | Signed as free agent | Will Sherriff | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent P Will Sherriff. |
| Apr 12, 2021 | Signed as free agent | Steven Souza Jr. | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RF Steven Souza Jr.. |
| Apr 12, 2021 | Signed as free agent | Brandon Leibrandt | — | Miami Marlins | Miami Marlins signed free agent P Brandon Leibrandt. |
| Apr 12, 2021 | Signed as free agent | Preston Guilmet | — | Miami Marlins | Miami Marlins signed free agent RHP Preston Guilmet to a minor league contract. |
| Apr 11, 2021 | Trade | Thairo Estrada | New York Yankees | San Francisco Giants | New York Yankees traded 2B Thairo Estrada to San Francisco Giants for cash. |
| Apr 10, 2021 | Signed as free agent | Baltazar Arredondo | — | Tampa Bay Rays | Tampa Bay Rays signed free agent LHP Baltazar Arredondo to a minor league contract. |
| Apr 9, 2021 | Trade | Edgar Santana | Pittsburgh Pirates | Atlanta Braves | Pittsburgh Pirates traded P Edgar Santana to Atlanta Braves for cash. |
| Apr 9, 2021 | Signed as free agent | Jordan Procyshen | — | Texas Rangers | Texas Rangers signed free agent C Jordan Procyshen to a minor league contract. |
| Apr 8, 2021 | Signed as free agent | Josue Rodriguez | — | Texas Rangers | Texas Rangers signed free agent LHP Josue Rodriguez to a minor league contract. |
| Apr 8, 2021 | Signed as free agent | Marcos Rodriguez | — | New York Mets | New York Mets signed free agent LHP Marcos Rodriguez to a minor league contract. |
| Apr 7, 2021 | Signed as free agent | Matt Jones | — | Los Angeles Angels | Los Angeles Angels signed free agent C Matt Jones. |
| Apr 6, 2021 | Signed as free agent | Jonathan Lucroy | — | Washington Nationals | Washington Nationals signed free agent C Jonathan Lucroy. |
| Apr 6, 2021 | Trade | Antonio Cabello | New York Yankees | Texas Rangers | New York Yankees traded OF Josh Stowers and C Antonio Cabello to Texas Rangers for 2B Rougned Odor and cash. |
| Apr 6, 2021 | Trade | Orlando Arcia | Milwaukee Brewers | Atlanta Braves | Atlanta Braves traded P Patrick Weigel and P Chad Sobotka to Milwaukee Brewers for SS Orlando Arcia. |
| Apr 6, 2021 | Signed as free agent | Tyler Olson | — | Boston Red Sox | Boston Red Sox signed free agent P Tyler Olson. |
| Apr 6, 2021 | Signed as free agent | Kyle Kasser | — | Los Angeles Angels | Los Angeles Angels signed free agent SS Kyle Kasser. |
| Apr 6, 2021 | Signed as free agent | Mike Montgomery | — | New York Yankees | New York Yankees signed free agent P Mike Montgomery. |
| Apr 6, 2021 | Signed as free agent | Peter Mooney | — | Minnesota Twins | Minnesota Twins signed free agent SS Peter Mooney to a minor league contract. |
| Apr 5, 2021 | Trade | Kyle Keller | Los Angeles Angels | Pittsburgh Pirates | Los Angeles Angels traded P Kyle Keller to Pittsburgh Pirates for cash. |
| Apr 5, 2021 | Trade | James Norwood | Chicago Cubs | San Diego Padres | Chicago Cubs traded P James Norwood to San Diego Padres for P Dauris Valdez. |
| Apr 5, 2021 | Signed as free agent | Frank Nigro | — | Minnesota Twins | Minnesota Twins signed free agent C Frank Nigro to a minor league contract. |
| Apr 5, 2021 | Signed as free agent | Juan Diaz | — | Texas Rangers | Texas Rangers signed free agent OF Juan Diaz to a minor league contract. |
| Apr 4, 2021 | Released | Tyler Bashlor | — | Pittsburgh Pirates | Pittsburgh Pirates released P Tyler Bashlor. |
| Apr 4, 2021 | Signed as free agent | R.J. Alvarez | — | Milwaukee Brewers | Milwaukee Brewers signed free agent P R.J. Alvarez. |
| Apr 3, 2021 | Signed as free agent | Héctor Rondón | — | Boston Red Sox | Boston Red Sox signed free agent P Hector Rondon. |
| Apr 3, 2021 | Signed as free agent | Gianpaul Gonzalez | — | Cleveland Guardians | Cleveland Indians signed free agent C Gianpaul Gonzalez. |
| Apr 3, 2021 | Signed as free agent | Preston Palmeiro | — | Los Angeles Angels | Los Angeles Angels signed free agent 1B Preston Palmeiro. |
| Apr 2, 2021 | Signed as free agent | Jesse Biddle | — | Atlanta Braves | Atlanta Braves signed free agent P Jesse Biddle. |
| Apr 2, 2021 | Signed as free agent | Zack Granite | — | Chicago White Sox | Chicago White Sox signed free agent CF Zack Granite. |
| Apr 2, 2021 | Signed as free agent | Keyvius Sampson | — | Chicago White Sox | Chicago White Sox signed free agent P Keyvius Sampson. |
| Apr 2, 2021 | Signed as free agent | Jake Gatewood | — | Los Angeles Angels | Los Angeles Angels signed free agent SS Jake Gatewood. |
| Apr 1, 2021 | Signed as free agent | Jhoulys Chacín | — | Colorado Rockies | Colorado Rockies signed free agent P Jhoulys Chacin. |
| Apr 1, 2021 | Signed as free agent | Steven Adderley | — | Miami Marlins | Miami Marlins signed free agent OF Steven Adderley. |
| Apr 1, 2021 | Signed as free agent | Roenis Elías | — | Seattle Mariners | Seattle Mariners signed free agent P Roenis Elias. |
| Apr 1, 2021 | Signed as free agent | Matt Magill | — | Seattle Mariners | Seattle Mariners signed free agent P Matt Magill. |
| Apr 1, 2021 | Signed as free agent | Nick Garland | — | Minnesota Twins | Minnesota Twins signed free agent C Nick Garland. |
| Apr 1, 2021 | Signed as free agent | Jhoulys Chacín | — | Colorado Rockies | Colorado Rockies signed free agent P Jhoulys Chacin. |
| Apr 1, 2021 | Signed as free agent | Jhoulys Chacín | — | Colorado Rockies | Colorado Rockies signed free agent P Jhoulys Chacin. |
| Mar 31, 2021 | Signed as free agent | Tony Wolters | — | Chicago Cubs | Chicago Cubs signed free agent C Tony Wolters. |
| Mar 31, 2021 | Signed as free agent | Yolmer Sánchez | — | Atlanta Braves | Atlanta Braves signed free agent 2B Yolmer Sanchez. |
| Mar 31, 2021 | Signed as free agent | Carl Edwards Jr. | — | Atlanta Braves | Atlanta Braves signed free agent P Carl Edwards Jr.. |
| Mar 31, 2021 | Signed as free agent | Stephen Wrenn | — | Seattle Mariners | Seattle Mariners signed free agent CF Stephen Wrenn to a minor league contract. |
| Mar 31, 2021 | Signed as free agent | Walbert Ureña | — | Los Angeles Angels | Los Angeles Angels signed free agent RHP Walbert Urena to a minor league contract. |
| Mar 31, 2021 | Signed as free agent | Jeremy Walker | — | San Francisco Giants | San Francisco Giants signed free agent RHP Jeremy Walker to a minor league contract. |
| Mar 30, 2021 | Signed as free agent | Jake Lamb | — | Chicago White Sox | Chicago White Sox signed free agent 3B Jake Lamb. |
| Mar 30, 2021 | Released | Yolmer Sánchez | — | Baltimore Orioles | Baltimore Orioles released 2B Yolmer Sanchez. |
| Mar 30, 2021 | Signed as free agent | Todd Frazier | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent 3B Todd Frazier. |
| Mar 30, 2021 | Signed as free agent | Tommy Hunter | — | New York Mets | New York Mets signed free agent P Tommy Hunter. |
| Mar 30, 2021 | Signed as free agent | Noé Ramirez | — | Los Angeles Angels | Los Angeles Angels signed free agent P Noe Ramirez. |
| Mar 30, 2021 | Signed as free agent | Jose Chavez | — | Atlanta Braves | Atlanta Braves signed free agent P Jose Chavez. |
| Mar 30, 2021 | Signed as free agent | Jake Lamb | — | Chicago White Sox | Chicago White Sox signed free agent 3B Jake Lamb. |
| Mar 30, 2021 | Signed as free agent | Jake Lamb | — | Chicago White Sox | Chicago White Sox signed free agent 3B Jake Lamb. |
| Mar 30, 2021 | Signed as free agent | Jake Lamb | — | Chicago White Sox | Chicago White Sox signed free agent 3B Jake Lamb. |
| Mar 30, 2021 | Signed as free agent | Jake Lamb | — | Chicago White Sox | Chicago White Sox signed free agent 3B Jake Lamb. |
| Mar 29, 2021 | Trade | James Hoyt | Miami Marlins | Los Angeles Angels | Miami Marlins traded P James Hoyt to Los Angeles Angels for cash. |
| Mar 29, 2021 | Signed as free agent | Steve Cishek | — | Los Angeles Angels | Los Angeles Angels signed free agent P Steve Cishek. |
| Mar 29, 2021 | Signed as free agent | Tony Watson | — | Los Angeles Angels | Los Angeles Angels signed free agent P Tony Watson. |
| Mar 29, 2021 | Released | Ben Taylor | — | Detroit Tigers | Detroit Tigers released P Ben Taylor. |
| Mar 29, 2021 | Released | Dylan Lee | — | Miami Marlins | Miami Marlins released P Dylan Lee. |
| Mar 29, 2021 | Released | Tony Wolters | — | Pittsburgh Pirates | Pittsburgh Pirates released C Tony Wolters. |
| Mar 29, 2021 | Signed as free agent | Osvaldo Abreu | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent SS Osvaldo Abreu. |
| Mar 29, 2021 | Signed as free agent | Andrew Romine | — | Chicago Cubs | Chicago Cubs signed free agent SS Andrew Romine. |
| Mar 29, 2021 | Signed as free agent | T.J. McFarland | — | Washington Nationals | Washington Nationals signed free agent P T.J. McFarland. |
| Mar 29, 2021 | Signed as free agent | Jason Kipnis | — | Atlanta Braves | Atlanta Braves signed free agent 2B Jason Kipnis. |
| Mar 29, 2021 | Signed as free agent | Jeff Mathis | — | Atlanta Braves | Atlanta Braves signed free agent C Jeff Mathis. |
| Mar 29, 2021 | Signed as free agent | Yasmany Tomás | — | Washington Nationals | Washington Nationals signed free agent RF Yasmany Tomas. |
| Mar 29, 2021 | Signed as free agent | Derek Dietrich | — | New York Yankees | New York Yankees signed free agent 2B Derek Dietrich. |
| Mar 29, 2021 | Signed as free agent | Samuel Dario | — | Milwaukee Brewers | Milwaukee Brewers signed free agent P Samuel Dario. |
| Mar 29, 2021 | Signed as free agent | Jorge De Leon | — | New York Mets | New York Mets signed free agent P Jorge De Leon. |
| Mar 29, 2021 | Signed as free agent | Steve Cishek | — | Los Angeles Angels | Los Angeles Angels signed free agent P Steve Cishek. |
| Mar 29, 2021 | Signed as free agent | Tony Watson | — | Los Angeles Angels | Los Angeles Angels signed free agent P Tony Watson. |
| Mar 29, 2021 | Signed as free agent | Tony Watson | — | Los Angeles Angels | Los Angeles Angels signed free agent LHP Tony Watson. |
| Mar 29, 2021 | Signed as free agent | Steve Cishek | — | Los Angeles Angels | Los Angeles Angels signed free agent RHP Steve Cishek. |
| Mar 28, 2021 | Released | Jake Lamb | — | Atlanta Braves | Atlanta Braves released 3B Jake Lamb. |
| Mar 28, 2021 | Released | C.J. Chatham | — | Philadelphia Phillies | Philadelphia Phillies released SS C.J. Chatham. |
| Mar 28, 2021 | Released | Jerry Vasto | — | Chicago Cubs | Chicago Cubs released P Jerry Vasto. |
| Mar 28, 2021 | Released | Jhoulys Chacín | — | New York Yankees | New York Yankees released P Jhoulys Chacin. |
| Mar 28, 2021 | Released | Christian Bethancourt | — | Philadelphia Phillies | Philadelphia Phillies released C Christian Bethancourt. |
| Mar 28, 2021 | Signed as free agent | Matt Adams | — | Colorado Rockies | Colorado Rockies signed free agent 1B Matt Adams. |
| Mar 28, 2021 | Signed as free agent | Robinson Chirinos | — | New York Yankees | New York Yankees signed free agent C Robinson Chirinos. |
| Mar 27, 2021 | Signed as free agent | Deolis Guerra | — | Athletics | Oakland Athletics signed free agent P Deolis Guerra. |
| Mar 27, 2021 | Released | Cameron Maybin | — | Chicago Cubs | Chicago Cubs released CF Cameron Maybin. |
| Mar 27, 2021 | Released | Robinson Chirinos | — | New York Yankees | New York Yankees released C Robinson Chirinos. |
| Mar 27, 2021 | Released | Derek Dietrich | — | New York Yankees | New York Yankees released 2B Derek Dietrich. |
| Mar 27, 2021 | Trade | Adam Plutko | Cleveland Guardians | Baltimore Orioles | Cleveland Indians traded P Adam Plutko to Baltimore Orioles for cash. |
| Mar 27, 2021 | Released | Noé Ramirez | — | Cincinnati Reds | Cincinnati Reds released P Noe Ramirez. |
| Mar 27, 2021 | Signed as free agent | Bryan Holaday | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent C Bryan Holaday. |
| Mar 27, 2021 | Released | Jason Kipnis | — | Atlanta Braves | Atlanta Braves released 2B Jason Kipnis. |
| Mar 27, 2021 | Signed as free agent | Erick Castillo | — | Chicago Cubs | Chicago Cubs signed free agent C Erick Castillo. |
| Mar 27, 2021 | Signed as free agent | Nick Howard | — | Cincinnati Reds | Cincinnati Reds signed free agent P Nick Howard. |
| Mar 27, 2021 | Signed as free agent | Carlos Herrera | — | Los Angeles Angels | Los Angeles Angels signed free agent SS Carlos Herrera. |
| Mar 27, 2021 | Released | Gio Gonzalez | — | Miami Marlins | Miami Marlins released P Gio Gonzalez. |
| Mar 27, 2021 | Released | Michael Ynoa | — | Philadelphia Phillies | Philadelphia Phillies released P Michael Ynoa. |
| Mar 27, 2021 | Released | Todd Frazier | — | Pittsburgh Pirates | Pittsburgh Pirates released 3B Todd Frazier. |
| Mar 27, 2021 | Released | Matt Magill | — | Seattle Mariners | Seattle Mariners released P Matt Magill. |
| Mar 27, 2021 | Released | Nick Vincent | — | Texas Rangers | Texas Rangers released P Nick Vincent. |
| Mar 27, 2021 | Signed as free agent | Jordan Zimmermann | — | Milwaukee Brewers | Milwaukee Brewers signed free agent P Jordan Zimmermann. |
| Mar 27, 2021 | Signed as free agent | Deolis Guerra | — | Athletics | Oakland Athletics signed free agent P Deolis Guerra. |
| Mar 27, 2021 | Signed as free agent | Jordan Zimmermann | — | Milwaukee Brewers | Milwaukee Brewers signed free agent P Jordan Zimmermann. |
| Mar 27, 2021 | Signed as free agent | Bryan Holaday | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent C Bryan Holaday. |
| Mar 26, 2021 | Signed as free agent | Wade LeBlanc | — | Baltimore Orioles | Baltimore Orioles signed free agent P Wade LeBlanc. |
| Mar 26, 2021 | Released | Jon Jay | — | Los Angeles Angels | Los Angeles Angels released CF Jon Jay. |
| Mar 26, 2021 | Released | Brad Boxberger | — | Milwaukee Brewers | Milwaukee Brewers released P Brad Boxberger. |
| Mar 26, 2021 | Released | Deolis Guerra | — | Athletics | Oakland Athletics released P Deolis Guerra. |
| Mar 26, 2021 | Released | Tony Watson | — | Philadelphia Phillies | Philadelphia Phillies released P Tony Watson. |
| Mar 26, 2021 | Released | Drew Butera | — | Texas Rangers | Texas Rangers released C Drew Butera. |
| Mar 26, 2021 | Signed as free agent | AJ Ramos | — | Los Angeles Angels | Los Angeles Angels signed free agent P AJ Ramos. |
| Mar 26, 2021 | Signed as free agent | Deolis Guerra | — | Athletics | Oakland Athletics signed free agent P Deolis Guerra. |
| Mar 26, 2021 | Signed as free agent | Wade LeBlanc | — | Baltimore Orioles | Baltimore Orioles signed free agent P Wade LeBlanc. |
| Mar 26, 2021 | Signed as free agent | Wade LeBlanc | — | Baltimore Orioles | Baltimore Orioles signed free agent P Wade LeBlanc. |
| Mar 26, 2021 | Signed as free agent | Wade LeBlanc | — | Baltimore Orioles | Baltimore Orioles signed free agent P Wade LeBlanc. |
| Mar 25, 2021 | Signed as free agent | Mitch Horacek | — | Atlanta Braves | Atlanta Braves signed free agent P Mitch Horacek. |
| Mar 25, 2021 | Released | Carl Edwards Jr. | — | Atlanta Braves | Atlanta Braves released P Carl Edwards Jr.. |
| Mar 25, 2021 | Released | Jesse Chavez | — | Los Angeles Angels | Los Angeles Angels released P Jesse Chavez. |
| Mar 25, 2021 | Released | Jordan Zimmermann | — | Milwaukee Brewers | Milwaukee Brewers released P Jordan Zimmermann. |
| Mar 25, 2021 | Released | Andrew Romine | — | Minnesota Twins | Minnesota Twins released SS Andrew Romine. |
| Mar 25, 2021 | Released | Jeff Mathis | — | Philadelphia Phillies | Philadelphia Phillies released C Jeff Mathis. |
| Mar 25, 2021 | Released | Iván Nova | — | Philadelphia Phillies | Philadelphia Phillies released P Ivan Nova. |
| Mar 25, 2021 | Released | Héctor Rondón | — | Philadelphia Phillies | Philadelphia Phillies released P Hector Rondon. |
| Mar 25, 2021 | Released | Roenis Elías | — | Seattle Mariners | Seattle Mariners released P Roenis Elias. |
| Mar 25, 2021 | Signed as free agent | Yefry Ramírez | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent P Yefry Ramirez. |
| Mar 25, 2021 | Signed as free agent | Godwin Bennett | — | Chicago White Sox | Chicago White Sox signed free agent OF Godwin Bennett. |
| Mar 24, 2021 | Signed as free agent | Alessandro Ercolani | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent P Alessandro Ercolani. |
| Mar 24, 2021 | Signed as free agent | Luis A. Rodriguez | — | New York Mets | New York Mets signed free agent P Luis Rodriguez. |
| Mar 23, 2021 | Released | Gerson Bautista | — | Seattle Mariners | Seattle Mariners released P Gerson Bautista. |
| Mar 23, 2021 | Signed as free agent | Ramón Rodríguez | — | Baltimore Orioles | Baltimore Orioles signed free agent C Ramon Rodriguez. |
| Mar 23, 2021 | Signed as free agent | Sam Hellinger | — | Cincinnati Reds | Cincinnati Reds signed free agent P Sam Hellinger. |
| Mar 23, 2021 | Signed as free agent | Junior Marin | — | Kansas City Royals | Kansas City Royals signed free agent OF Junior Marin. |
| Mar 23, 2021 | Signed as free agent | David Martinez | — | Miami Marlins | Miami Marlins signed free agent C David Martinez to a minor league contract. |
| Mar 22, 2021 | Signed as free agent | Heath Hembree | — | Cincinnati Reds | Cincinnati Reds signed free agent P Heath Hembree. |
| Mar 22, 2021 | Signed as free agent | Martin Cervenka | — | New York Mets | New York Mets signed free agent C Martin Cervenka. |
| Mar 22, 2021 | Released | Brendan McCurry | — | Los Angeles Angels | Los Angeles Angels released P Brendan McCurry. |
| Mar 22, 2021 | Signed as free agent | Melvin Adón | — | San Francisco Giants | San Francisco Giants signed free agent P Melvin Adon. |
| Mar 22, 2021 | Signed as free agent | Blake Grant-Parks | — | Texas Rangers | Texas Rangers signed free agent DH Blake Grant-Parks. |
| Mar 22, 2021 | Signed as free agent | Kyle Lobstein | — | Washington Nationals | Washington Nationals signed free agent P Kyle Lobstein. |
| Mar 22, 2021 | Signed as free agent | Ty Blach | — | Baltimore Orioles | Baltimore Orioles signed free agent P Ty Blach. |
| Mar 22, 2021 | Signed as free agent | Kolton Ingram | — | Los Angeles Angels | Los Angeles Angels signed free agent P Kolton Ingram. |
| Mar 22, 2021 | Signed as free agent | Heath Hembree | — | Cincinnati Reds | Cincinnati Reds signed free agent P Heath Hembree. |
| Mar 21, 2021 | Signed as free agent | Steven Wright | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent P Steven Wright. |
| Mar 21, 2021 | Signed as free agent | Steven Wright | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent P Steven Wright. |
| Mar 21, 2021 | Signed as free agent | Jose Chavez | — | Milwaukee Brewers | Milwaukee Brewers signed free agent P Jose Chavez. |
| Mar 19, 2021 | Signed as free agent | Phil Pfeifer | — | San Francisco Giants | San Francisco Giants signed free agent P Philip Pfeifer. |
| Mar 19, 2021 | Signed as free agent | Heath Fillmyer | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent P Heath Fillmyer. |
| Mar 19, 2021 | Signed as free agent | Stone Garrett | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent CF Stone Garrett. |
| Mar 19, 2021 | Signed as free agent | Jarett Rindfleisch | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent C Jarett Rindfleisch. |
| Mar 19, 2021 | Signed as free agent | Carlos Martínez | — | Atlanta Braves | Atlanta Braves signed free agent C Carlos Martinez. |
| Mar 19, 2021 | Signed as free agent | Daniel Santana | — | Boston Red Sox | Boston Red Sox signed free agent P Daniel Santana. |
| Mar 19, 2021 | Signed as free agent | Colby Morris | — | New York Mets | New York Mets signed free agent P Colby Morris. |
| Mar 19, 2021 | Signed as free agent | Isaias Quiroz | — | Texas Rangers | Texas Rangers signed free agent C Isaias Quiroz. |
| Mar 19, 2021 | Released | Bradley Roney | — | Arizona Diamondbacks | Arizona Diamondbacks released P Bradley Roney. |
| Mar 19, 2021 | Signed as free agent | Andrew Kittredge | — | Tampa Bay Rays | Tampa Bay Rays signed free agent P Andrew Kittredge. |
| Mar 19, 2021 | Signed as free agent | Jean Cosme | — | Los Angeles Angels | Los Angeles Angels signed free agent P Jean Cosme. |
| Mar 19, 2021 | Signed as free agent | Zack Godley | — | Milwaukee Brewers | Milwaukee Brewers signed free agent P Zack Godley. |
| Mar 19, 2021 | Signed as free agent | Phil Pfeifer | — | San Francisco Giants | San Francisco Giants signed free agent P Phil Pfeifer. |
| Mar 19, 2021 | Signed as free agent | German Tapia | — | Tampa Bay Rays | Tampa Bay Rays signed free agent P German Tapia. |
| Mar 18, 2021 | Released | Andrew Kittredge | — | Tampa Bay Rays | Tampa Bay Rays released P Andrew Kittredge. |
| Mar 18, 2021 | Signed as free agent | Mark Leiter Jr. | — | Detroit Tigers | Detroit Tigers signed free agent P Mark Leiter Jr.. |
| Mar 18, 2021 | Signed as free agent | Darin Gillies | — | Seattle Mariners | Seattle Mariners signed free agent P Darin Gillies. |
| Mar 18, 2021 | Signed as free agent | Pedro Munoz | — | Toronto Blue Jays | Toronto Blue Jays signed free agent P Pedro Munoz. |
| Mar 18, 2021 | Signed as free agent | Janos Meszaros | — | Houston Astros | Houston Astros signed free agent RHP Johnny Meszaros to a minor league contract. |
| Mar 17, 2021 | Signed as free agent | Cesar Rojas | — | Houston Astros | Houston Astros signed free agent P Cesar Rojas. |
| Mar 17, 2021 | Signed as free agent | Roger Duran | — | Minnesota Twins | Minnesota Twins signed free agent P Roger Duran. |
| Mar 17, 2021 | Signed as free agent | Krisspy Valdez | — | New York Mets | New York Mets signed free agent P Krisspy Valdez. |
| Mar 17, 2021 | Signed as free agent | Felipe De La Cruz | — | New York Mets | New York Mets signed free agent P Felipe De La Cruz. |
| Mar 16, 2021 | Signed as free agent | Maikel Franco | — | Baltimore Orioles | Baltimore Orioles signed free agent 3B Maikel Franco. |
| Mar 16, 2021 | Signed as free agent | Billy Hamilton | — | Chicago White Sox | Chicago White Sox signed free agent CF Billy Hamilton. |
| Mar 16, 2021 | Signed as free agent | Billy Hamilton | — | Chicago White Sox | Chicago White Sox signed free agent CF Billy Hamilton. |
| Mar 16, 2021 | Signed as free agent | Jeromy Sosa | — | Tampa Bay Rays | Tampa Bay Rays signed free agent P Jeromy Sosa. |
| Mar 16, 2021 | Signed as free agent | Juan Rodriguez | — | Tampa Bay Rays | Tampa Bay Rays signed free agent P Juan Rodriguez. |
| Mar 16, 2021 | Signed as free agent | Maikel Franco | — | Baltimore Orioles | Baltimore Orioles signed free agent 3B Maikel Franco. |
| Mar 16, 2021 | Signed as free agent | Maikel Franco | — | Baltimore Orioles | Baltimore Orioles signed free agent 3B Maikel Franco. |
| Mar 16, 2021 | Signed as free agent | Maikel Franco | — | Baltimore Orioles | Baltimore Orioles signed free agent 3B Maikel Franco. |
| Mar 16, 2021 | Signed as free agent | Roberto Peña | — | Minnesota Twins | Minnesota Twins signed free agent C Roberto Pena to a minor league contract. |
| Mar 15, 2021 | Signed as free agent | Chasen Bradford | — | Atlanta Braves | Atlanta Braves signed free agent P Chasen Bradford. |
| Mar 15, 2021 | Signed as free agent | Sam Tewes | — | New York Mets | New York Mets signed free agent P Sam Tewes. |
| Mar 14, 2021 | Released | Phil Pfeifer | — | Atlanta Braves | Atlanta Braves released P Philip Pfeifer. |
| Mar 14, 2021 | Signed as free agent | Ryan Casteel | — | Atlanta Braves | Atlanta Braves signed free agent C Ryan Casteel. |
| Mar 13, 2021 | Released | Billy Hamilton | — | Cleveland Guardians | Cleveland Indians released CF Billy Hamilton. |
| Mar 12, 2021 | Trade | Mike Freeman | Cleveland Guardians | Cincinnati Reds | Cleveland Indians traded SS Mike Freeman to Cincinnati Reds for $0. |
| Mar 12, 2021 | Signed as free agent | Trevor Cahill | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent P Trevor Cahill. |
| Mar 12, 2021 | Signed as free agent | Kieran Lovegrove | — | Los Angeles Angels | Los Angeles Angels signed free agent RHP Kieran Lovegrove to a minor league contract. |
| Mar 10, 2021 | Signed as free agent | Luis Alvarez | — | New York Mets | New York Mets signed free agent P Luis Alvarez. |
| Mar 10, 2021 | Signed as free agent | Cristian Jimenez | — | Minnesota Twins | Minnesota Twins signed free agent P Cristian Jimenez. |
| Mar 9, 2021 | Signed as free agent | Jogly Garcia | — | Boston Red Sox | Boston Red Sox signed free agent P Jogly Garcia. |
| Mar 9, 2021 | Signed as free agent | Yendy Gomez | — | Los Angeles Angels | Los Angeles Angels signed free agent P Yendy Gomez. |
| Mar 9, 2021 | Signed as free agent | Sebastián Elizalde | — | New York Mets | New York Mets signed free agent RF Sebastian Elizalde to a minor league contract. |
| Mar 8, 2021 | Signed as free agent | Jackie Bradley Jr. | — | Milwaukee Brewers | Milwaukee Brewers signed free agent CF Jackie Bradley Jr.. |
| Mar 8, 2021 | Signed as free agent | Jake Odorizzi | — | Houston Astros | Houston Astros signed free agent P Jake Odorizzi. |
| Mar 8, 2021 | Signed as free agent | Jackie Bradley Jr. | — | Milwaukee Brewers | Milwaukee Brewers signed free agent CF Jackie Bradley Jr.. |
| Mar 8, 2021 | Signed as free agent | Jackie Bradley Jr. | — | Milwaukee Brewers | Milwaukee Brewers signed free agent CF Jackie Bradley Jr.. |
| Mar 7, 2021 | Signed as free agent | Danny Santana | — | Boston Red Sox | Boston Red Sox signed free agent SS Danny Santana. |
| Mar 7, 2021 | Trade | Shendrik Apostel | Pittsburgh Pirates | Chicago Cubs | Pittsburgh Pirates traded 1B Shendrik Apostel to Chicago Cubs for P Duane Underwood Jr.. |
| Mar 7, 2021 | Released | Jeremy Jeffress | — | Washington Nationals | Washington Nationals released P Jeremy Jeffress. |
| Mar 7, 2021 | Signed as free agent | Danny Santana | — | Boston Red Sox | Boston Red Sox signed free agent SS Danny Santana. |
| Mar 7, 2021 | Signed as free agent | Damian Henderson | — | Cincinnati Reds | Cincinnati Reds signed free agent LHP Damian Henderson to a minor league contract. |
| Mar 6, 2021 | Signed as free agent | Jose Alvarez | — | San Francisco Giants | San Francisco Giants signed free agent P Jose Alvarez. |
| Mar 6, 2021 | Signed as free agent | Kinn Omosako | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent P Kinn Omosako. |
| Mar 6, 2021 | Signed as free agent | Roy Morales | — | Minnesota Twins | Minnesota Twins signed free agent C Roy Morales to a minor league contract. |
| Mar 5, 2021 | Released | Drew Weeks | — | Arizona Diamondbacks | Arizona Diamondbacks released RF Drew Weeks. |
| Mar 5, 2021 | Signed as free agent | Jarrod Dyson | — | Kansas City Royals | Kansas City Royals signed free agent CF Jarrod Dyson. |
| Mar 5, 2021 | Signed as free agent | Eric Sogard | — | Chicago Cubs | Chicago Cubs signed free agent 2B Eric Sogard. |
| Mar 5, 2021 | Signed as free agent | Eric Sogard | — | Chicago Cubs | Chicago Cubs signed free agent 2B Eric Sogard. |
| Mar 5, 2021 | Signed as free agent | Phili Silverio | — | Milwaukee Brewers | Milwaukee Brewers signed free agent P Phili Silverio. |
| Mar 5, 2021 | Signed as free agent | Dilan Figueredo | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent P Dilan Figueredo. |
| Mar 5, 2021 | Signed as free agent | Juan Rojas | — | Minnesota Twins | Minnesota Twins signed free agent P Juan Rojas. |
| Mar 5, 2021 | Signed as free agent | Jarrod Dyson | — | Kansas City Royals | Kansas City Royals signed free agent CF Jarrod Dyson. |
| Mar 5, 2021 | Signed as free agent | Jarrod Dyson | — | Kansas City Royals | Kansas City Royals signed free agent CF Jarrod Dyson. |
| Mar 5, 2021 | Signed as free agent | Jarrod Dyson | — | Kansas City Royals | Kansas City Royals signed free agent CF Jarrod Dyson. |
| Mar 5, 2021 | Signed as free agent | Jarrod Dyson | — | Kansas City Royals | Kansas City Royals signed free agent CF Jarrod Dyson. |
| Mar 5, 2021 | Signed as free agent | Jarrod Dyson | — | Kansas City Royals | Kansas City Royals signed free agent CF Jarrod Dyson. |
| Mar 4, 2021 | Signed as free agent | Gio Gonzalez | — | Miami Marlins | Miami Marlins signed free agent P Gio Gonzalez. |
| Mar 4, 2021 | Signed as free agent | Anthony Swarzak | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent P Anthony Swarzak. |
| Mar 4, 2021 | Signed as free agent | Manny Barreda | — | Baltimore Orioles | Baltimore Orioles signed free agent P Manny Barreda. |
| Mar 4, 2021 | Signed as free agent | Anthony Swarzak | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent P Anthony Swarzak. |
| Mar 3, 2021 | Signed as free agent | Taylor Motter | — | Colorado Rockies | Colorado Rockies signed free agent 2B Taylor Motter. |
| Mar 3, 2021 | Signed as free agent | Damek Tomscha | — | Minnesota Twins | Minnesota Twins signed free agent 3B Damek Tomscha. |
| Mar 2, 2021 | Signed as free agent | Justin Bour | — | San Francisco Giants | San Francisco Giants signed free agent 1B Justin Bour. |
| Mar 2, 2021 | Signed as free agent | Ryan Tepera | — | Chicago Cubs | Chicago Cubs signed free agent P Ryan Tepera. |
| Mar 2, 2021 | Signed as free agent | Ryan Tepera | — | Chicago Cubs | Chicago Cubs signed free agent RHP Ryan Tepera. |
| Mar 1, 2021 | Signed as free agent | Ryan Meisinger | — | Chicago Cubs | Chicago Cubs signed free agent P Ryan Meisinger. |
| Mar 1, 2021 | Signed as free agent | Miguel Hernandez | — | Atlanta Braves | Atlanta Braves signed free agent P Miguel Hernandez. |
| Mar 1, 2021 | Signed as free agent | Jair Casanova | — | Atlanta Braves | Atlanta Braves signed free agent OF Jair Casanova. |
| Mar 1, 2021 | Signed as free agent | Victor Lizarraga | — | San Diego Padres | San Diego Padres signed free agent RHP Victor Lizarraga to a minor league contract. |
| Feb 28, 2021 | Trade | Travis Bergen | Arizona Diamondbacks | Toronto Blue Jays | Arizona Diamondbacks traded P Travis Bergen to Toronto Blue Jays for $0. |
| Feb 27, 2021 | Trade | Zach Bryant | Chicago Cubs | Boston Red Sox | Chicago Cubs traded P Zach Bryant to Boston Red Sox. |
| Feb 27, 2021 | Signed as free agent | Drew Hutchison | — | Detroit Tigers | Detroit Tigers signed free agent P Drew Hutchison. |
| Feb 27, 2021 | Signed as free agent | Pedro Strop | — | Chicago Cubs | Chicago Cubs signed free agent P Pedro Strop. |
| Feb 27, 2021 | Signed as free agent | Michael Gomez | — | New York Yankees | New York Yankees signed free agent P Michael Gomez. |
| Feb 27, 2021 | Signed as free agent | Raino Coran | — | Chicago Cubs | Chicago Cubs signed free agent OF Raino Coran. |
| Feb 26, 2021 | Signed as free agent | Tyler Clippard | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent P Tyler Clippard. |
| Feb 26, 2021 | Signed as free agent | Carlos Jimenez | — | Chicago White Sox | Chicago White Sox signed free agent Carlos Jimenez. |
| Feb 26, 2021 | Signed as free agent | Norge Vera | — | Chicago White Sox | Chicago White Sox signed free agent P Norge Vera. |
| Feb 26, 2021 | Signed as free agent | Dario Borrero | — | Chicago White Sox | Chicago White Sox signed free agent Dario Borrero. |
| Feb 26, 2021 | Signed as free agent | Adrian Gil | — | Chicago White Sox | Chicago White Sox signed free agent Adrian Gil. |
| Feb 26, 2021 | Signed as free agent | Victor Quezada | — | Chicago White Sox | Chicago White Sox signed free agent Victor Quezada. |
| Feb 26, 2021 | Signed as free agent | Manuel Guariman | — | Chicago White Sox | Chicago White Sox signed free agent Manuel Guariman. |
| Feb 26, 2021 | Signed as free agent | Carlos Hinestroza | — | Chicago White Sox | Chicago White Sox signed free agent Carlos Hinestroza. |
| Feb 26, 2021 | Signed as free agent | Travis Snider | — | Atlanta Braves | Atlanta Braves signed free agent LF Travis Snider. |
| Feb 26, 2021 | Signed as free agent | Ben Holmes | — | Chicago Cubs | Chicago Cubs signed free agent P Ben Holmes. |
| Feb 26, 2021 | Signed as free agent | Jeremy Jeffress | — | Washington Nationals | Washington Nationals signed free agent P Jeremy Jeffress. |
| Feb 26, 2021 | Signed as free agent | Andrés Machado | — | Washington Nationals | Washington Nationals signed free agent P Andres Machado. |
| Feb 26, 2021 | Signed as free agent | Steven Okert | — | Miami Marlins | Miami Marlins signed free agent P Steven Okert. |
| Feb 26, 2021 | Signed as free agent | Benjamin Dum | — | Atlanta Braves | Atlanta Braves signed free agent P Benjamin Dum. |
| Feb 26, 2021 | Signed as free agent | Patrick Kivlehan | — | San Diego Padres | San Diego Padres signed free agent RF Patrick Kivlehan. |
| Feb 26, 2021 | Signed as free agent | Jeremy Jeffress | — | Washington Nationals | Washington Nationals signed free agent P Jeremy Jeffress. |
| Feb 26, 2021 | Signed as free agent | Tyler Clippard | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent P Tyler Clippard. |
| Feb 26, 2021 | Signed as free agent | Ricardo Pinto | — | Detroit Tigers | Detroit Tigers signed free agent P Ricardo Pinto. |
| Feb 26, 2021 | Signed as free agent | Scott Kazmir | — | San Francisco Giants | San Francisco Giants signed free agent P Scott Kazmir. |
| Feb 26, 2021 | Signed as free agent | Tyson Ross | — | Texas Rangers | Texas Rangers signed free agent P Tyson Ross. |
| Feb 26, 2021 | Signed as free agent | Scott Kazmir | — | San Francisco Giants | San Francisco Giants signed free agent P Scott Kazmir. |
| Feb 26, 2021 | Signed as free agent | Patrick Kivlehan | — | San Diego Padres | San Diego Padres signed free agent RF Patrick Kivlehan. |
| Feb 26, 2021 | Signed as free agent | Keythel Key | — | Los Angeles Angels | Los Angeles Angels signed free agent P Keythel Key. |
| Feb 26, 2021 | Signed as free agent | Edinson Valdespina | — | Los Angeles Angels | Los Angeles Angels signed free agent P Edinson Valdespina. |
| Feb 26, 2021 | Signed as free agent | Edgar Quero | — | Los Angeles Angels | Los Angeles Angels signed free agent C Edgar Quero. |
| Feb 25, 2021 | Signed as free agent | Tommy Milone | — | Toronto Blue Jays | Toronto Blue Jays signed free agent P Tommy Milone. |
| Feb 25, 2021 | Trade | Jack Mayfield | Atlanta Braves | Los Angeles Angels | Atlanta Braves traded 2B Jack Mayfield to Los Angeles Angels for cash. |
| Feb 25, 2021 | Signed as free agent | Cameron Maybin | — | Chicago Cubs | Chicago Cubs signed free agent CF Cameron Maybin. |
| Feb 25, 2021 | Signed as free agent | Ryan Goins | — | Atlanta Braves | Atlanta Braves signed free agent 2B Ryan Goins. |
| Feb 25, 2021 | Signed as free agent | Mikie Mahtook | — | Chicago White Sox | Chicago White Sox signed free agent CF Mikie Mahtook. |
| Feb 25, 2021 | Signed as free agent | Jesse Chavez | — | Los Angeles Angels | Los Angeles Angels signed free agent P Jesse Chavez. |
| Feb 25, 2021 | Signed as free agent | Tommy Milone | — | Toronto Blue Jays | Toronto Blue Jays signed free agent P Tommy Milone. |
| Feb 25, 2021 | Signed as free agent | Ryan Goins | — | Atlanta Braves | Atlanta Braves signed free agent 2B Ryan Goins. |
| Feb 25, 2021 | Signed as free agent | Jhoan Contreras | — | Washington Nationals | Washington Nationals signed free agent OF Jhoan Contreras. |
| Feb 24, 2021 | Signed as free agent | Marwin Gonzalez | — | Boston Red Sox | Boston Red Sox signed free agent 3B Marwin Gonzalez. |
| Feb 24, 2021 | Trade | Dustin Fowler | Athletics | Pittsburgh Pirates | Oakland Athletics traded CF Dustin Fowler to Pittsburgh Pirates for cash. |
| Feb 24, 2021 | Signed as free agent | Caleb Joseph | — | New York Mets | New York Mets signed free agent C Caleb Joseph. |
| Feb 24, 2021 | Signed as free agent | Caleb Joseph | — | New York Mets | New York Mets signed free agent C Caleb Joseph. |
| Feb 24, 2021 | Signed as free agent | Marwin Gonzalez | — | Boston Red Sox | Boston Red Sox signed free agent SS Marwin Gonzalez. |
| Feb 24, 2021 | Signed as free agent | Marwin Gonzalez | — | Boston Red Sox | Boston Red Sox signed free agent SS Marwin Gonzalez. |
| Feb 24, 2021 | Signed as free agent | Marwin Gonzalez | — | Boston Red Sox | Boston Red Sox signed free agent SS Marwin Gonzalez. |
| Feb 24, 2021 | Signed as free agent | Marwin Gonzalez | — | Boston Red Sox | Boston Red Sox signed free agent SS Marwin Gonzalez. |
| Feb 24, 2021 | Signed as free agent | Marwin Gonzalez | — | Boston Red Sox | Boston Red Sox signed free agent SS Marwin Gonzalez. |
| Feb 23, 2021 | Signed as free agent | Justin Wilson | — | New York Yankees | New York Yankees signed free agent LHP Justin Wilson. |
| Feb 23, 2021 | Signed as free agent | Mitch Moreland | — | Athletics | Oakland Athletics signed free agent 1B Mitch Moreland. |
| Feb 23, 2021 | Signed as free agent | Jake Lamb | — | Atlanta Braves | Atlanta Braves signed free agent 3B Jake Lamb. |
| Feb 23, 2021 | Signed as free agent | Ian Kennedy | — | Texas Rangers | Texas Rangers signed free agent RHP Ian Kennedy to a minor league contract and invited him to spring training. |
| Feb 23, 2021 | Signed as free agent | Travis Shaw | — | Milwaukee Brewers | Milwaukee Brewers signed free agent 3B Travis Shaw to a minor league contract and invited him to spring training. |
| Feb 23, 2021 | Signed as free agent | Jake Lamb | — | Atlanta Braves | Atlanta Braves signed free agent 3B Jake Lamb. |
| Feb 23, 2021 | Trade | Ryan Noda | Toronto Blue Jays | Los Angeles Dodgers | Toronto Blue Jays traded OF Ryan Noda to Los Angeles Dodgers. |
| Feb 23, 2021 | Signed as free agent | Julio Teheran | — | Detroit Tigers | Detroit Tigers signed free agent RHP Julio Teheran to a minor league contract and invited him to spring training. |
| Feb 23, 2021 | Signed as free agent | Jose Moreno | — | Chicago Cubs | Chicago Cubs signed free agent P Jose Moreno. |
| Feb 23, 2021 | Signed as free agent | James Dykstra | — | Toronto Blue Jays | Toronto Blue Jays signed free agent P James Dykstra. |
| Feb 23, 2021 | Signed as free agent | Justin Miller | — | Washington Nationals | Washington Nationals signed free agent P Justin Miller. |
| Feb 23, 2021 | Signed as free agent | Runelvis Toribio | — | Chicago Cubs | Chicago Cubs signed free agent P Runelvis Toribio. |
| Feb 23, 2021 | Signed as free agent | Mitch Moreland | — | Athletics | Oakland Athletics signed free agent 1B Mitch Moreland. |
| Feb 23, 2021 | Signed as free agent | Mitch Moreland | — | Athletics | Oakland Athletics signed free agent 1B Mitch Moreland. |
| Feb 22, 2021 | Signed as free agent | Brad Brach | — | Kansas City Royals | Kansas City Royals signed free agent RHP Brad Brach to a minor league contract and invited him to spring training. |
| Feb 22, 2021 | Signed as free agent | Asdrúbal Cabrera | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent 3B Asdrubal Cabrera. |
| Feb 22, 2021 | Signed as free agent | Trevor Rosenthal | — | Athletics | Oakland Athletics signed free agent RHP Trevor Rosenthal. |
| Feb 22, 2021 | Signed as free agent | Chaz Roe | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP Chaz Roe. |
| Feb 22, 2021 | Signed as free agent | Collin McHugh | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP Collin McHugh. |
| Feb 22, 2021 | Signed as free agent | Brett Anderson | — | Milwaukee Brewers | Milwaukee Brewers signed free agent LHP Brett Anderson. |
| Feb 22, 2021 | Signed as free agent | Brett Gardner | — | New York Yankees | New York Yankees signed free agent CF Brett Gardner. |
| Feb 22, 2021 | Signed as free agent | Andrew Romine | — | Minnesota Twins | Minnesota Twins signed free agent SS Andrew Romine to a minor league contract and invited him to spring training. |
| Feb 22, 2021 | Signed as free agent | Brad Brach | — | Kansas City Royals | Kansas City Royals signed free agent P Brad Brach. |
| Feb 22, 2021 | Signed as free agent | Collin McHugh | — | Tampa Bay Rays | Tampa Bay Rays signed free agent P Collin McHugh. |
| Feb 22, 2021 | Signed as free agent | Asdrúbal Cabrera | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent SS Asdrubal Cabrera. |
| Feb 22, 2021 | Signed as free agent | Brett Gardner | — | New York Yankees | New York Yankees signed free agent LF Brett Gardner. |
| Feb 22, 2021 | Signed as free agent | Brett Anderson | — | Milwaukee Brewers | Milwaukee Brewers signed free agent P Brett Anderson. |
| Feb 22, 2021 | Signed as free agent | Asdrúbal Cabrera | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent SS Asdrubal Cabrera. |
| Feb 22, 2021 | Signed as free agent | Collin McHugh | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP Collin McHugh. |
| Feb 22, 2021 | Signed as free agent | Brett Gardner | — | New York Yankees | New York Yankees signed free agent LF Brett Gardner. |
| Feb 22, 2021 | Signed as free agent | Brett Anderson | — | Milwaukee Brewers | Milwaukee Brewers signed free agent LHP Brett Anderson. |
| Feb 22, 2021 | Signed as free agent | Brett Gardner | — | New York Yankees | New York Yankees signed free agent LF Brett Gardner. |
| Feb 21, 2021 | Signed as free agent | Aaron Sanchez | — | San Francisco Giants | San Francisco Giants signed free agent RHP Aaron Sanchez. |
| Feb 21, 2021 | Signed as free agent | Wynston Sawyer | — | San Diego Padres | San Diego Padres signed free agent C Wynston Sawyer to a minor league contract and invited him to spring training. |
| Feb 21, 2021 | Signed as free agent | Kevin Pillar | — | New York Mets | New York Mets signed free agent CF Kevin Pillar. |
| Feb 21, 2021 | Released | Jason Creasy | — | Atlanta Braves | Atlanta Braves released RHP Jason Creasy. |
| Feb 21, 2021 | Signed as free agent | Travis Demeritte | — | Atlanta Braves | Atlanta Braves signed free agent LF Travis Demeritte to a minor league contract. |
| Feb 21, 2021 | Signed | Shun Yamaguchi | — | San Francisco Giants | San Francisco Giants signed P Shun Yamaguchi. |
| Feb 21, 2021 | Signed | Shun Yamaguchi | — | San Francisco Giants | San Francisco Giants signed P Shun Yamaguchi. |
| Feb 21, 2021 | Signed as free agent | Wynston Sawyer | — | San Diego Padres | San Diego Padres signed free agent C Wynston Sawyer. |
| Feb 21, 2021 | Signed as free agent | Travis Demeritte | — | Atlanta Braves | Atlanta Braves signed free agent 2B Travis Demeritte. |
| Feb 21, 2021 | Signed as free agent | Kevin Pillar | — | New York Mets | New York Mets signed free agent CF Kevin Pillar. |
| Feb 21, 2021 | Signed as free agent | Kevin Pillar | — | New York Mets | New York Mets signed free agent CF Kevin Pillar. |
| Feb 21, 2021 | Signed as free agent | Kevin Pillar | — | New York Mets | New York Mets signed free agent CF Kevin Pillar. |
| Feb 21, 2021 | Signed as free agent | Kevin Pillar | — | New York Mets | New York Mets signed free agent CF Kevin Pillar. |
| Feb 20, 2021 | Signed as free agent | Todd Frazier | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent 3B Todd Frazier to a minor league contract and invited him to spring training. |
| Feb 20, 2021 | Signed as free agent | Taijuan Walker | — | New York Mets | New York Mets signed free agent RHP Taijuan Walker. |
| Feb 20, 2021 | Signed as free agent | Jake Marisnick | — | Chicago Cubs | Chicago Cubs signed free agent CF Jake Marisnick. |
| Feb 20, 2021 | Signed as free agent | Taijuan Walker | — | New York Mets | New York Mets signed free agent P Taijuan Walker. |
| Feb 20, 2021 | Signed as free agent | Taijuan Walker | — | New York Mets | New York Mets signed free agent P Taijuan Walker. |
| Feb 20, 2021 | Signed as free agent | Taijuan Walker | — | New York Mets | New York Mets signed free agent RHP Taijuan Walker. |
| Feb 20, 2021 | Signed as free agent | Taijuan Walker | — | New York Mets | New York Mets signed free agent RHP Taijuan Walker. |
| Feb 19, 2021 | Signed as free agent | Yusmeiro Petit | — | Athletics | Oakland Athletics signed free agent RHP Yusmeiro Petit. |
| Feb 19, 2021 | Signed as free agent | Ken Giles | — | Seattle Mariners | Seattle Mariners signed free agent RHP Ken Giles. |
| Feb 19, 2021 | Signed as free agent | Justin Turner | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent 3B Justin Turner. |
| Feb 19, 2021 | Signed as free agent | Ryan Lavarnway | — | Cleveland Guardians | Cleveland Indians signed free agent C Ryan Lavarnway to a minor league contract and invited him to spring training. |
| Feb 19, 2021 | Signed as free agent | Wily Peralta | — | Detroit Tigers | Detroit Tigers signed free agent RHP Wily Peralta to a minor league contract and invited him to spring training. |
| Feb 19, 2021 | Signed as free agent | Ben Taylor | — | Detroit Tigers | Detroit Tigers signed free agent P Ben Taylor. |
| Feb 19, 2021 | Signed as free agent | Wily Peralta | — | Detroit Tigers | Detroit Tigers signed free agent P Wily Peralta. |
| Feb 19, 2021 | Signed as free agent | Ryan Lavarnway | — | Cleveland Guardians | Cleveland Indians signed free agent C Ryan Lavarnway. |
| Feb 19, 2021 | Signed as free agent | Arquedion Muller | — | Philadelphia Phillies | Philadelphia Phillies signed free agent 2B Arquedion Muller. |
| Feb 19, 2021 | Signed as free agent | Yusmeiro Petit | — | Athletics | Oakland Athletics signed free agent P Yusmeiro Petit. |
| Feb 19, 2021 | Signed as free agent | Justin Turner | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent 3B Justin Turner. |
| Feb 19, 2021 | Signed as free agent | Yusmeiro Petit | — | Athletics | Oakland Athletics signed free agent P Yusmeiro Petit. |
| Feb 19, 2021 | Signed as free agent | Justin Turner | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent 3B Justin Turner. |
| Feb 19, 2021 | Signed as free agent | Justin Turner | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent 3B Justin Turner. |
| Feb 19, 2021 | Signed as free agent | Justin Turner | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent 3B Justin Turner. |
| Feb 18, 2021 | Signed as free agent | Brandon Workman | — | Chicago Cubs | Chicago Cubs signed free agent RHP Brandon Workman. |
| Feb 18, 2021 | Signed as free agent | James Paxton | — | Seattle Mariners | Seattle Mariners signed free agent LHP James Paxton. |
| Feb 18, 2021 | Signed as free agent | Mark Melancon | — | San Diego Padres | San Diego Padres signed free agent RHP Mark Melancon. |
| Feb 18, 2021 | Signed as free agent | Sergio Romo | — | Athletics | Oakland Athletics signed free agent RHP Sergio Romo. |
| Feb 18, 2021 | Signed as free agent | Tyler Naquin | — | Cincinnati Reds | Cincinnati Reds signed free agent RF Tyler Naquin to a minor league contract and invited him to spring training. |
| Feb 18, 2021 | Signed as free agent | Matt Shoemaker | — | Minnesota Twins | Minnesota Twins signed free agent RHP Matt Shoemaker. |
| Feb 18, 2021 | Signed as free agent | Keone Kela | — | San Diego Padres | San Diego Padres signed free agent RHP Keone Kela. |
| Feb 18, 2021 | Signed as free agent | Oliver Pérez | — | Cleveland Guardians | Cleveland Indians signed free agent LHP Oliver Perez to a minor league contract and invited him to spring training. |
| Feb 18, 2021 | Signed as free agent | Jordan Zimmermann | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Jordan Zimmermann to a minor league contract and invited him to spring training. |
| Feb 18, 2021 | Signed as free agent | Brad Boxberger | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Brad Boxberger to a minor league contract and invited him to spring training. |
| Feb 18, 2021 | Signed as free agent | Terrance Gore | — | Atlanta Braves | Atlanta Braves signed free agent CF Terrance Gore to a minor league contract. |
| Feb 18, 2021 | Signed as free agent | Mark Melancon | — | San Diego Padres | San Diego Padres signed free agent P Mark Melancon. |
| Feb 18, 2021 | Signed as free agent | Keone Kela | — | San Diego Padres | San Diego Padres signed free agent P Keone Kela. |
| Feb 18, 2021 | Signed as free agent | Sergio Romo | — | Athletics | Oakland Athletics signed free agent P Sergio Romo. |
| Feb 18, 2021 | Signed as free agent | Matt Shoemaker | — | Minnesota Twins | Minnesota Twins signed free agent P Matt Shoemaker. |
| Feb 18, 2021 | Signed as free agent | Mark Melancon | — | San Diego Padres | San Diego Padres signed free agent P Mark Melancon. |
| Feb 18, 2021 | Signed as free agent | Keone Kela | — | San Diego Padres | San Diego Padres signed free agent P Keone Kela. |
| Feb 18, 2021 | Signed as free agent | Sergio Romo | — | Athletics | Oakland Athletics signed free agent P Sergio Romo. |
| Feb 18, 2021 | Signed as free agent | Matt Shoemaker | — | Minnesota Twins | Minnesota Twins signed free agent RHP Matt Shoemaker. |
| Feb 17, 2021 | Trade | Chris Mazza | Boston Red Sox | Tampa Bay Rays | Tampa Bay Rays traded C Ronaldo Hernandez and SS Nick Sogard to Boston Red Sox for Jeffrey Springs, Chris Mazza and cash. |
| Feb 17, 2021 | Signed as free agent | Tyler Anderson | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent LHP Tyler Anderson. |
| Feb 17, 2021 | Signed as free agent | Jake McGee | — | San Francisco Giants | San Francisco Giants signed free agent LHP Jake McGee. |
| Feb 17, 2021 | Signed as free agent | Adam Duvall | — | Miami Marlins | Miami Marlins signed free agent LF Adam Duvall. |
| Feb 17, 2021 | Signed as free agent | Brad Miller | — | Philadelphia Phillies | Philadelphia Phillies signed free agent 2B Brad Miller. |
| Feb 17, 2021 | Signed as free agent | Tony Watson | — | Philadelphia Phillies | Philadelphia Phillies signed free agent LHP Tony Watson to a minor league contract and invited him to spring training. |
| Feb 17, 2021 | Trade | John Curtiss | Tampa Bay Rays | Miami Marlins | Tampa Bay Rays traded RHP John Curtiss to Miami Marlins for 1B Evan Edwards. |
| Feb 17, 2021 | Signed as free agent | Jay Jackson | — | San Francisco Giants | San Francisco Giants signed free agent RHP Jay Jackson to a minor league contract and invited him to spring training. |
| Feb 17, 2021 | Signed as free agent | Nick Tropeano | — | San Francisco Giants | San Francisco Giants signed free agent RHP Nick Tropeano to a minor league contract and invited him to spring training. |
| Feb 17, 2021 | Signed as free agent | Jake Arrieta | — | Chicago Cubs | Chicago Cubs signed free agent RHP Jake Arrieta. |
| Feb 17, 2021 | Signed as free agent | Matt Harvey | — | Baltimore Orioles | Baltimore Orioles signed free agent RHP Matt Harvey to a minor league contract and invited him to spring training. |
| Feb 17, 2021 | Signed as free agent | T.J. McFarland | — | Washington Nationals | Washington Nationals signed free agent LHP T.J. McFarland to a minor league contract and invited him to spring training. |
| Feb 17, 2021 | Signed as free agent | Gerardo Parra | — | Washington Nationals | Washington Nationals signed free agent LF Gerardo Parra to a minor league contract and invited him to spring training. |
| Feb 17, 2021 | Signed as free agent | Oliver Drake | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP Oliver Drake. |
| Feb 17, 2021 | Signed as free agent | Rich Hill | — | Tampa Bay Rays | Tampa Bay Rays signed free agent LHP Rich Hill. |
| Feb 17, 2021 | Signed as free agent | Cale Coshow | — | Detroit Tigers | Detroit Tigers signed free agent RHP Cale Coshow to a minor league contract. |
| Feb 17, 2021 | Signed as free agent | Matt Davidson | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent 1B Matt Davidson to a minor league contract and invited him to spring training. |
| Feb 17, 2021 | Signed as free agent | Gerardo Parra | — | Washington Nationals | Washington Nationals signed free agent LF Gerardo Parra. |
| Feb 17, 2021 | Signed as free agent | Nick Tropeano | — | San Francisco Giants | San Francisco Giants signed free agent P Nick Tropeano. |
| Feb 17, 2021 | Signed as free agent | Jay Jackson | — | San Francisco Giants | San Francisco Giants signed free agent P Jay Jackson. |
| Feb 17, 2021 | Signed as free agent | Matt Davidson | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent DH Matt Davidson. |
| Feb 17, 2021 | Signed as free agent | Eduardo Mares | — | Kansas City Royals | Kansas City Royals signed free agent P Eduardo Mares. |
| Feb 17, 2021 | Signed as free agent | Rich Hill | — | Tampa Bay Rays | Tampa Bay Rays signed free agent P Rich Hill. |
| Feb 17, 2021 | Signed as free agent | Tyler Anderson | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent P Tyler Anderson. |
| Feb 17, 2021 | Signed as free agent | Brad Miller | — | Philadelphia Phillies | Philadelphia Phillies signed free agent SS Brad Miller. |
| Feb 17, 2021 | Signed as free agent | Adam Duvall | — | Miami Marlins | Miami Marlins signed free agent LF Adam Duvall. |
| Feb 17, 2021 | Signed as free agent | Jake McGee | — | San Francisco Giants | San Francisco Giants signed free agent P Jake McGee. |
| Feb 17, 2021 | Signed as free agent | Jake Arrieta | — | Chicago Cubs | Chicago Cubs signed free agent P Jake Arrieta. |
| Feb 17, 2021 | Signed as free agent | Rich Hill | — | Tampa Bay Rays | Tampa Bay Rays signed free agent LHP Rich Hill. |
| Feb 17, 2021 | Signed as free agent | Jake McGee | — | San Francisco Giants | San Francisco Giants signed free agent LHP Jake McGee. |
| Feb 17, 2021 | Signed as free agent | Tyler Anderson | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent LHP Tyler Anderson. |
| Feb 17, 2021 | Signed as free agent | Brad Miller | — | Philadelphia Phillies | Philadelphia Phillies signed free agent SS Brad Miller. |
| Feb 17, 2021 | Signed as free agent | Adam Duvall | — | Miami Marlins | Miami Marlins signed free agent LF Adam Duvall. |
| Feb 17, 2021 | Signed as free agent | Jake Arrieta | — | Chicago Cubs | Chicago Cubs signed free agent RHP Jake Arrieta. |
| Feb 17, 2021 | Signed as free agent | Adam Duvall | — | Miami Marlins | Miami Marlins signed free agent LF Adam Duvall. |
| Feb 17, 2021 | Signed as free agent | Brad Miller | — | Philadelphia Phillies | Philadelphia Phillies signed free agent SS Brad Miller. |
| Feb 17, 2021 | Signed as free agent | Ramón Flores | — | Washington Nationals | Washington Nationals signed free agent RF Ramon Flores to a minor league contract. |
| Feb 16, 2021 | Signed as free agent | C.J. Cron | — | Colorado Rockies | Colorado Rockies signed free agent 1B C.J. Cron to a minor league contract and invited him to spring training. |
| Feb 16, 2021 | Signed as free agent | Hirokazu Sawamura | — | Boston Red Sox | Boston Red Sox signed free agent RHP Hirokazu Sawamura. |
| Feb 16, 2021 | Signed as free agent | Jeff Mathis | — | Philadelphia Phillies | Philadelphia Phillies signed free agent C Jeff Mathis to a minor league contract and invited him to spring training. |
| Feb 16, 2021 | Released | Brad Brach | — | New York Mets | New York Mets released RHP Brad Brach. |
| Feb 16, 2021 | Signed as free agent | Blake Parker | — | Cleveland Guardians | Cleveland Indians signed free agent RHP Blake Parker to a minor league contract and invited him to spring training. |
| Feb 16, 2021 | Trade | Josh Sborz | Los Angeles Dodgers | Texas Rangers | Los Angeles Dodgers traded RHP Josh Sborz to Texas Rangers for RHP Jhan Zambrano. |
| Feb 16, 2021 | Signed as free agent | Cam Bedrosian | — | Cincinnati Reds | Cincinnati Reds signed free agent RHP Cam Bedrosian to a minor league contract and invited him to spring training. |
| Feb 16, 2021 | Signed as free agent | Mike Fiers | — | Athletics | Oakland Athletics signed free agent RHP Mike Fiers. |
| Feb 16, 2021 | Signed as free agent | Jeff Mathis | — | Philadelphia Phillies | Philadelphia Phillies signed free agent C Jeff Mathis to a minor league contract and invited him to spring training. |
| Feb 16, 2021 | Signed as free agent | Hirokazu Sawamura | — | Boston Red Sox | Boston Red Sox signed free agent RHP Hirokazu Sawamura. |
| Feb 16, 2021 | Signed as free agent | Shawn Morimando | — | Miami Marlins | Miami Marlins signed free agent LHP Shawn Morimando to a minor league contract and invited him to spring training. |
| Feb 16, 2021 | Signed as free agent | Angel Acevedo | — | Chicago White Sox | Chicago White Sox signed free agent RHP Angel Acevedo to a minor league contract. |
| Feb 16, 2021 | Signed as free agent | John Andreoli | — | San Diego Padres | San Diego Padres signed free agent OF John Andreoli to a minor league contract. |
| Feb 16, 2021 | Signed as free agent | Hirokazu Sawamura | — | Boston Red Sox | Boston Red Sox signed free agent P Hirokazu Sawamura. |
| Feb 16, 2021 | Signed as free agent | Shawn Morimando | — | Miami Marlins | Miami Marlins signed free agent P Shawn Morimando. |
| Feb 16, 2021 | Signed as free agent | Blake Parker | — | Cleveland Guardians | Cleveland Indians signed free agent P Blake Parker. |
| Feb 16, 2021 | Signed as free agent | Riley Yeatman | — | San Diego Padres | San Diego Padres signed free agent P Riley Yeatman. |
| Feb 16, 2021 | Signed as free agent | Hirokazu Sawamura | — | Boston Red Sox | Boston Red Sox signed free agent P Hirokazu Sawamura. |
| Feb 16, 2021 | Signed as free agent | Hirokazu Sawamura | — | Boston Red Sox | Boston Red Sox signed free agent P Hirokazu Sawamura. |
| Feb 15, 2021 | Signed as free agent | Billy Hamilton | — | Cleveland Guardians | Cleveland Indians signed free agent CF Billy Hamilton to a minor league contract and invited him to spring training. |
| Feb 15, 2021 | Signed as free agent | Jason Kipnis | — | Atlanta Braves | Atlanta Braves signed free agent 2B Jason Kipnis to a minor league contract and invited him to spring training. |
| Feb 15, 2021 | Trade | Derek Fisher | Toronto Blue Jays | Milwaukee Brewers | Toronto Blue Jays traded RF Derek Fisher to Milwaukee Brewers for Player To Be Named Later and cash. |
| Feb 15, 2021 | Trade | Derek Fisher | — | Milwaukee Brewers | traded to Milwaukee Brewers for . |
| Feb 15, 2021 | Signed as free agent | Jermaine Palacios | — | Minnesota Twins | Minnesota Twins signed free agent SS Jermaine Palacios to a minor league contract. |
| Feb 15, 2021 | Signed as free agent | Aaron Brown | — | Athletics | Oakland Athletics signed free agent LHP Aaron Brown to a minor league contract. |
| Feb 15, 2021 | Signed as free agent | Justin Courtney | — | Los Angeles Angels | Los Angeles Angels signed free agent P Justin Courtney. |
| Feb 14, 2021 | Signed as free agent | Tommy Hunter | — | New York Mets | New York Mets signed free agent RHP Tommy Hunter to a minor league contract and invited him to spring training. |
| Feb 14, 2021 | Signed as free agent | Mike Montgomery | — | New York Mets | New York Mets signed free agent LHP Mike Montgomery to a minor league contract and invited him to spring training. |
| Feb 14, 2021 | Signed as free agent | Matt Szczur | — | St. Louis Cardinals | St. Louis Cardinals signed free agent CF Matt Szczur to a minor league contract and invited him to spring training. |
| Feb 14, 2021 | Signed as free agent | Matt Szczur | — | St. Louis Cardinals | St. Louis Cardinals signed free agent CF Matt Szczur to a minor league contract and invited him to spring training. |
| Feb 14, 2021 | Signed as free agent | Matt Szczur | — | St. Louis Cardinals | St. Louis Cardinals signed free agent LF Matt Szczur. |
| Feb 13, 2021 | Signed as free agent | Robinson Chirinos | — | New York Yankees | New York Yankees signed free agent C Robinson Chirinos to a minor league contract and invited him to spring training. |
| Feb 13, 2021 | Signed as free agent | Nick Goody | — | New York Yankees | New York Yankees signed free agent RHP Nick Goody to a minor league contract and invited him to spring training. |
| Feb 13, 2021 | Signed as free agent | Nick Goody | — | New York Yankees | New York Yankees signed free agent P Nick Goody. |
| Feb 12, 2021 | Trade | Adam Kolarek | Los Angeles Dodgers | Athletics | Los Angeles Dodgers traded LHP Adam Kolarek and RF Cody Thomas to Oakland Athletics for 3B Sheldon Neuse and RHP Gus Varland. |
| Feb 12, 2021 | Signed as free agent | John Hicks | — | Texas Rangers | Texas Rangers signed free agent C John Hicks to a minor league contract and invited him to spring training. |
| Feb 12, 2021 | Signed as free agent | Hyeon-Jong Yang | — | Texas Rangers | Texas Rangers signed free agent LHP Hyun-jong Yang to a minor league contract and invited him to spring training. |
| Feb 12, 2021 | Signed as free agent | Brock Holt | — | Texas Rangers | Texas Rangers signed free agent 2B Brock Holt to a minor league contract and invited him to spring training. |
| Feb 12, 2021 | Signed as free agent | Alex Colomé | — | Minnesota Twins | Minnesota Twins signed free agent RHP Alex Colome. |
| Feb 12, 2021 | Trade | Dylan Floro | Los Angeles Dodgers | Miami Marlins | Miami Marlins traded LHP Alex Vesia and RHP Kyle Hurt to Los Angeles Dodgers for Dylan Floro. |
| Feb 12, 2021 | Signed as free agent | Shelby Miller | — | Chicago Cubs | Chicago Cubs signed free agent RHP Shelby Miller to a minor league contract and invited him to spring training. |
| Feb 12, 2021 | Signed as free agent | Jose Lobatón | — | Chicago Cubs | Chicago Cubs signed free agent C Jose Lobaton to a minor league contract and invited him to spring training. |
| Feb 12, 2021 | Signed as free agent | Stetson Allie | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP Stetson Allie to a minor league contract and invited him to spring training. |
| Feb 12, 2021 | Signed as free agent | Adam Morgan | — | Chicago Cubs | Chicago Cubs signed free agent LHP Adam Morgan to a minor league contract and invited him to spring training. |
| Feb 12, 2021 | Signed as free agent | Nomar Mazara | — | Detroit Tigers | Detroit Tigers signed free agent RF Nomar Mazara. |
| Feb 12, 2021 | Signed as free agent | Brian Moran | — | Tampa Bay Rays | Tampa Bay Rays signed free agent LHP Brian Moran to a minor league contract and invited him to spring training. |
| Feb 12, 2021 | Signed as free agent | Louis Head | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP Louis Head to a minor league contract and invited him to spring training. |
| Feb 12, 2021 | Signed as free agent | Joey Krehbiel | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP Joey Krehbiel to a minor league contract and invited him to spring training. |
| Feb 12, 2021 | Released | Ben Heller | — | New York Yankees | New York Yankees released RHP Ben Heller. |
| Feb 12, 2021 | Signed as free agent | Martín Pérez | — | Boston Red Sox | Boston Red Sox signed free agent LHP Martin Perez. |
| Feb 12, 2021 | Signed as free agent | Chris Herrmann | — | Boston Red Sox | Boston Red Sox signed free agent C Chris Herrmann to a minor league contract and invited him to spring training. |
| Feb 12, 2021 | Signed as free agent | Joe Panik | — | Toronto Blue Jays | Toronto Blue Jays signed free agent 2B Joe Panik to a minor league contract and invited him to spring training. |
| Feb 12, 2021 | Released | Shun Yamaguchi | — | Toronto Blue Jays | Toronto Blue Jays released RHP Shun Yamaguchi. |
| Feb 12, 2021 | Released | Jeremy Walker | — | Atlanta Braves | Atlanta Braves released RHP Jeremy Walker. |
| Feb 12, 2021 | Trade | Ali Sánchez | New York Mets | St. Louis Cardinals | New York Mets traded C Ali Sanchez to St. Louis Cardinals for cash. |
| Feb 12, 2021 | Signed as free agent | Robinson Leyer | — | Minnesota Twins | Minnesota Twins signed free agent RHP Robinson Leyer to a minor league contract. |
| Feb 12, 2021 | Signed as free agent | Andrew Albers | — | Minnesota Twins | Minnesota Twins signed free agent LHP Andrew Albers to a minor league contract and invited him to spring training. |
| Feb 12, 2021 | Signed as free agent | Ben Gamel | — | Cleveland Guardians | Cleveland Indians signed free agent LF Ben Gamel to a minor league contract and invited him to spring training. |
| Feb 12, 2021 | Signed as free agent | Derek Dietrich | — | New York Yankees | New York Yankees signed free agent 2B Derek Dietrich to a minor league contract and invited him to spring training. |
| Feb 12, 2021 | Signed as free agent | Jay Bruce | — | New York Yankees | New York Yankees signed free agent RF Jay Bruce to a minor league contract and invited him to spring training. |
| Feb 12, 2021 | Trade | Ali Sánchez | — | St. Louis Cardinals | traded to St. Louis Cardinals for . |
| Feb 12, 2021 | Signed as free agent | Aaron Northcraft | — | San Diego Padres | San Diego Padres signed free agent RHP Aaron Northcraft to a minor league contract and invited him to spring training. |
| Feb 12, 2021 | Signed as free agent | Miguel Díaz | — | San Diego Padres | San Diego Padres signed free agent RHP Miguel Diaz to a minor league contract and invited him to spring training. |
| Feb 12, 2021 | Signed as free agent | Andrew Albers | — | Minnesota Twins | Minnesota Twins signed free agent LHP Andrew Albers to a minor league contract and invited him to spring training. |
| Feb 12, 2021 | Signed as free agent | Alex Colomé | — | Minnesota Twins | Minnesota Twins signed free agent RHP Alex Colome. |
| Feb 12, 2021 | Trade | Dylan Floro | — | Miami Marlins | traded to Miami Marlins for . |
| Feb 12, 2021 | Trade | Alex Vesia | — | Los Angeles Dodgers | traded to Los Angeles Dodgers for . |
| Feb 12, 2021 | Signed as free agent | Jose Lobatón | — | Chicago Cubs | Chicago Cubs signed free agent C Jose Lobaton to a minor league contract and invited him to spring training. |
| Feb 12, 2021 | Signed as free agent | Adam Morgan | — | Chicago Cubs | Chicago Cubs signed free agent LHP Adam Morgan to a minor league contract and invited him to spring training. |
| Feb 12, 2021 | Signed as free agent | Shelby Miller | — | Chicago Cubs | Chicago Cubs signed free agent RHP Shelby Miller to a minor league contract and invited him to spring training. |
| Feb 12, 2021 | Signed as free agent | Travis Jankowski | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RF Travis Jankowski to a minor league contract. |
| Feb 12, 2021 | Signed as free agent | Angel Franco | — | Kansas City Royals | Kansas City Royals signed free agent 2B Angel Franco to a minor league contract. |
| Feb 12, 2021 | Signed as free agent | Joe Panik | — | Toronto Blue Jays | Toronto Blue Jays signed free agent 2B Joe Panik. |
| Feb 12, 2021 | Signed as free agent | John Hicks | — | Texas Rangers | Texas Rangers signed free agent C John Hicks. |
| Feb 12, 2021 | Signed as free agent | Hyeon-Jong Yang | — | Texas Rangers | Texas Rangers signed free agent P Hyeon-Jong Yang. |
| Feb 12, 2021 | Signed as free agent | Brian Moran | — | Tampa Bay Rays | Tampa Bay Rays signed free agent P Brian Moran. |
| Feb 12, 2021 | Signed as free agent | Joey Krehbiel | — | Tampa Bay Rays | Tampa Bay Rays signed free agent P Joey Krehbiel. |
| Feb 12, 2021 | Signed as free agent | Louis Head | — | Tampa Bay Rays | Tampa Bay Rays signed free agent P Louis Head. |
| Feb 12, 2021 | Signed as free agent | Stetson Allie | — | Tampa Bay Rays | Tampa Bay Rays signed free agent P Stetson Allie. |
| Feb 12, 2021 | Signed as free agent | Aaron Northcraft | — | San Diego Padres | San Diego Padres signed free agent P Aaron Northcraft. |
| Feb 12, 2021 | Signed as free agent | Miguel Díaz | — | San Diego Padres | San Diego Padres signed free agent P Miguel Diaz. |
| Feb 12, 2021 | Signed as free agent | Andrew Albers | — | Minnesota Twins | Minnesota Twins signed free agent P Andrew Albers. |
| Feb 12, 2021 | Signed as free agent | Jose Lobatón | — | Chicago Cubs | Chicago Cubs signed free agent C Jose Lobaton. |
| Feb 12, 2021 | Signed as free agent | Adam Morgan | — | Chicago Cubs | Chicago Cubs signed free agent P Adam Morgan. |
| Feb 12, 2021 | Signed as free agent | Shelby Miller | — | Chicago Cubs | Chicago Cubs signed free agent P Shelby Miller. |
| Feb 12, 2021 | Signed as free agent | Chris Herrmann | — | Boston Red Sox | Boston Red Sox signed free agent C Chris Herrmann. |
| Feb 12, 2021 | Signed as free agent | Scarlyn Lebron | — | Chicago Cubs | Chicago Cubs signed free agent P Scarlyn Lebron. |
| Feb 12, 2021 | Signed as free agent | Alex Colomé | — | Minnesota Twins | Minnesota Twins signed free agent P Alex Colome. |
| Feb 12, 2021 | Signed as free agent | Nomar Mazara | — | Detroit Tigers | Detroit Tigers signed free agent RF Nomar Mazara. |
| Feb 12, 2021 | Signed as free agent | Martín Pérez | — | Boston Red Sox | Boston Red Sox signed free agent P Martin Perez. |
| Feb 12, 2021 | Signed as free agent | Martín Pérez | — | Boston Red Sox | Boston Red Sox signed free agent P Martin Perez. |
| Feb 12, 2021 | Signed as free agent | Alex Colomé | — | Minnesota Twins | Minnesota Twins signed free agent RHP Alex Colome. |
| Feb 11, 2021 | Signed as free agent | Alex McRae | — | Chicago White Sox | Chicago White Sox signed free agent RHP Alex McRae to a minor league contract and invited him to spring training. |
| Feb 11, 2021 | Signed as free agent | Tony Wolters | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent C Tony Wolters to a minor league contract and invited him to spring training. |
| Feb 11, 2021 | Signed as free agent | Tim Beckham | — | Chicago White Sox | Chicago White Sox signed free agent SS Tim Beckham to a minor league contract and invited him to spring training. |
| Feb 11, 2021 | Signed as free agent | Jonathan Lucroy | — | Chicago White Sox | Chicago White Sox signed free agent C Jonathan Lucroy to a minor league contract and invited him to spring training. |
| Feb 11, 2021 | Signed as free agent | Shane Carle | — | Cincinnati Reds | Cincinnati Reds signed free agent RHP Shane Carle to a minor league contract and invited him to spring training. |
| Feb 11, 2021 | Signed as free agent | Brian Goodwin | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent LF Brian Goodwin to a minor league contract and invited him to spring training. |
| Feb 11, 2021 | Signed as free agent | Phil Gosselin | — | Los Angeles Angels | Los Angeles Angels signed free agent 2B Phil Gosselin to a minor league contract and invited him to spring training. |
| Feb 11, 2021 | Signed as free agent | Juan Lagares | — | Los Angeles Angels | Los Angeles Angels signed free agent CF Juan Lagares to a minor league contract and invited him to spring training. |
| Feb 11, 2021 | Signed as free agent | Trevor Bauer | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Trevor Bauer. |
| Feb 11, 2021 | Signed as free agent | David Phelps | — | Toronto Blue Jays | Toronto Blue Jays signed free agent RHP David Phelps. |
| Feb 11, 2021 | Signed as free agent | Chris Devenski | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Chris Devenski to a minor league contract and invited him to spring training. |
| Feb 11, 2021 | Signed as free agent | Jonathan Villar | — | New York Mets | New York Mets signed free agent SS Jonathan Villar. |
| Feb 11, 2021 | Signed as free agent | Carlos Navas | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Carlos Navas to a minor league contract and invited him to spring training. |
| Feb 11, 2021 | Signed as free agent | Greg Bird | — | Colorado Rockies | Colorado Rockies signed free agent 1B Greg Bird to a minor league contract and invited him to spring training. |
| Feb 11, 2021 | Released | David Freitas | — | Milwaukee Brewers | Milwaukee Brewers released C David Freitas. |
| Feb 11, 2021 | Signed as free agent | Christian Lopes | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent 2B Christian Lopes to a minor league contract and invited him to spring training. |
| Feb 11, 2021 | Signed as free agent | Dee Strange-Gordon | — | Cincinnati Reds | Cincinnati Reds signed free agent 2B Dee Strange-Gordon to a minor league contract. |
| Feb 11, 2021 | Signed as free agent | Juan Lagares | — | Los Angeles Angels | Los Angeles Angels signed free agent CF Juan Lagares to a minor league contract and invited him to spring training. |
| Feb 11, 2021 | Signed as free agent | Phil Gosselin | — | Los Angeles Angels | Los Angeles Angels signed free agent 2B Phil Gosselin to a minor league contract and invited him to spring training. |
| Feb 11, 2021 | Signed as free agent | Shane Carle | — | Cincinnati Reds | Cincinnati Reds signed free agent RHP Shane Carle to a minor league contract and invited him to spring training. |
| Feb 11, 2021 | Signed as free agent | Tim Beckham | — | Chicago White Sox | Chicago White Sox signed free agent SS Tim Beckham to a minor league contract and invited him to spring training. |
| Feb 11, 2021 | Signed as free agent | Jonathan Lucroy | — | Chicago White Sox | Chicago White Sox signed free agent C Jonathan Lucroy to a minor league contract and invited him to spring training. |
| Feb 11, 2021 | Signed as free agent | Alex McRae | — | Chicago White Sox | Chicago White Sox signed free agent RHP Alex McRae to a minor league contract and invited him to spring training. |
| Feb 11, 2021 | Signed as free agent | Christian Lopes | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent 2B Christian Lopes to a minor league contract and invited him to spring training. |
| Feb 11, 2021 | Signed as free agent | Carlos Navas | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Carlos Navas to a minor league contract and invited him to spring training. |
| Feb 11, 2021 | Signed as free agent | Chris Devenski | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Chris Devenski to a minor league contract and invited him to spring training. |
| Feb 11, 2021 | Signed as free agent | Hendrik Clementina | — | Atlanta Braves | Atlanta Braves signed free agent C Hendrik Clementina to a minor league contract. |
| Feb 11, 2021 | Signed as free agent | Drew Ward | — | Detroit Tigers | Detroit Tigers signed free agent 1B Drew Ward to a minor league contract. |
| Feb 11, 2021 | Signed as free agent | Jon Jay | — | Los Angeles Angels | Los Angeles Angels signed free agent OF Jon Jay to a minor league contract and invited him to spring training. |
| Feb 11, 2021 | Signed as free agent | Brian Goodwin | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent CF Brian Goodwin. |
| Feb 11, 2021 | Signed as free agent | Juan Lagares | — | Los Angeles Angels | Los Angeles Angels signed free agent CF Juan Lagares. |
| Feb 11, 2021 | Signed as free agent | Phil Gosselin | — | Los Angeles Angels | Los Angeles Angels signed free agent 2B Phil Gosselin. |
| Feb 11, 2021 | Signed as free agent | Greg Bird | — | Colorado Rockies | Colorado Rockies signed free agent 1B Greg Bird. |
| Feb 11, 2021 | Signed as free agent | Shane Carle | — | Cincinnati Reds | Cincinnati Reds signed free agent P Shane Carle. |
| Feb 11, 2021 | Signed as free agent | Tim Beckham | — | Chicago White Sox | Chicago White Sox signed free agent SS Tim Beckham. |
| Feb 11, 2021 | Signed as free agent | Alex McRae | — | Chicago White Sox | Chicago White Sox signed free agent P Alex McRae. |
| Feb 11, 2021 | Signed as free agent | Carlos Navas | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent P Carlos Navas. |
| Feb 11, 2021 | Signed as free agent | David Phelps | — | Toronto Blue Jays | Toronto Blue Jays signed free agent P David Phelps. |
| Feb 11, 2021 | Signed as free agent | Jonathan Villar | — | New York Mets | New York Mets signed free agent SS Jonathan Villar. |
| Feb 11, 2021 | Signed as free agent | Trevor Bauer | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent P Trevor Bauer. |
| Feb 11, 2021 | Signed as free agent | Jonathan Villar | — | New York Mets | New York Mets signed free agent SS Jonathan Villar. |
| Feb 11, 2021 | Signed as free agent | David Phelps | — | Toronto Blue Jays | Toronto Blue Jays signed free agent P David Phelps. |
| Feb 11, 2021 | Signed as free agent | Trevor Bauer | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent P Trevor Bauer. |
| Feb 11, 2021 | Signed as free agent | Jonathan Villar | — | New York Mets | New York Mets signed free agent SS Jonathan Villar. |
| Feb 11, 2021 | Signed as free agent | Jonathan Villar | — | New York Mets | New York Mets signed free agent SS Jonathan Villar. |
| Feb 11, 2021 | Signed as free agent | Jonathan Villar | — | New York Mets | New York Mets signed free agent SS Jonathan Villar. |
| Feb 10, 2021 | Signed as free agent | Didi Gregorius | — | Philadelphia Phillies | Philadelphia Phillies signed free agent SS Didi Gregorius. |
| Feb 10, 2021 | Signed as free agent | Greg Garcia | — | Detroit Tigers | Detroit Tigers signed free agent 2B Greg Garcia to a minor league contract and invited him to spring training. |
| Feb 10, 2021 | Signed as free agent | Renato Núñez | — | Detroit Tigers | Detroit Tigers signed free agent 1B Renato Nunez to a minor league contract and invited him to spring training. |
| Feb 10, 2021 | Signed as free agent | Jed Lowrie | — | Athletics | Oakland Athletics signed free agent SS Jed Lowrie to a minor league contract and invited him to spring training. |
| Feb 10, 2021 | Signed as free agent | Mike Foltynewicz | — | Texas Rangers | Texas Rangers signed free agent RHP Mike Foltynewicz. |
| Feb 10, 2021 | Signed as free agent | Darren O'Day | — | New York Yankees | New York Yankees signed free agent RHP Darren O'Day. |
| Feb 10, 2021 | Signed as free agent | Braden Shipley | — | Cincinnati Reds | Cincinnati Reds signed free agent RHP Braden Shipley to a minor league contract and invited him to spring training. |
| Feb 10, 2021 | Trade | Andrew Benintendi | Boston Red Sox | Kansas City Royals | Boston Red Sox Traded cash and LF Andrew Benintendi to Kansas City Royals; Kansas City Royals Traded Player To Be Named Later, Player To Be Named Later and CF Franchy Cordero to Boston Red Sox; Kansas City Royals Traded CF Khalil Lee to New York Mets and New York Mets Traded Player To Be Named Later and Josh Winckowski to Boston Red Sox. |
| Feb 10, 2021 | Signed as free agent | Albert Almora Jr. | — | New York Mets | New York Mets signed free agent CF Albert Almora Jr.. |
| Feb 10, 2021 | Trade | Johan Quezada | Philadelphia Phillies | St. Louis Cardinals | Philadelphia Phillies traded RHP Johan Quezada to St. Louis Cardinals for cash. |
| Feb 10, 2021 | Signed as free agent | Brandon Kintzler | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RHP Brandon Kintzler to a minor league contract and invited him to spring training. |
| Feb 10, 2021 | Signed as free agent | Matt Joyce | — | Philadelphia Phillies | Philadelphia Phillies signed free agent LF Matt Joyce to a minor league contract and invited him to spring training. |
| Feb 10, 2021 | Signed as free agent | Alejandro Mateo | — | Chicago White Sox | Chicago White Sox signed free agent RHP Alejandro Mateo to a minor league contract. |
| Feb 10, 2021 | Signed as free agent | Darren O'Day | — | New York Yankees | New York Yankees signed free agent RHP Darren O'Day. |
| Feb 10, 2021 | Signed as free agent | Braden Shipley | — | Cincinnati Reds | Cincinnati Reds signed free agent RHP Braden Shipley to a minor league contract and invited him to spring training. |
| Feb 10, 2021 | Signed as free agent | Jed Lowrie | — | Athletics | Oakland Athletics signed free agent SS Jed Lowrie. |
| Feb 10, 2021 | Signed as free agent | Renato Núñez | — | Detroit Tigers | Detroit Tigers signed free agent 3B Renato Nunez. |
| Feb 10, 2021 | Signed as free agent | Braden Shipley | — | Cincinnati Reds | Cincinnati Reds signed free agent P Braden Shipley. |
| Feb 10, 2021 | Signed as free agent | Gabriel Ochoa | — | Toronto Blue Jays | Toronto Blue Jays signed free agent P Gabriel Ochoa. |
| Feb 10, 2021 | Signed as free agent | Eliander Alcalde | — | Toronto Blue Jays | Toronto Blue Jays signed free agent P Eliander Alcalde. |
| Feb 10, 2021 | Signed as free agent | Yondrei Rojas | — | Toronto Blue Jays | Toronto Blue Jays signed free agent P Yondrei Rojas. |
| Feb 10, 2021 | Signed as free agent | Keiner Leon | — | Toronto Blue Jays | Toronto Blue Jays signed free agent P Keiner Leon. |
| Feb 10, 2021 | Signed as free agent | Orlando Rubio | — | Minnesota Twins | Minnesota Twins signed free agent P Orlando Rubio. |
| Feb 10, 2021 | Signed as free agent | Neiyerbe Obeso | — | Toronto Blue Jays | Toronto Blue Jays signed free agent P Neiyerbe Obeso. |
| Feb 10, 2021 | Signed as free agent | Mike Foltynewicz | — | Texas Rangers | Texas Rangers signed free agent P Mike Foltynewicz. |
| Feb 10, 2021 | Signed as free agent | Didi Gregorius | — | Philadelphia Phillies | Philadelphia Phillies signed free agent SS Didi Gregorius. |
| Feb 10, 2021 | Signed as free agent | Albert Almora Jr. | — | New York Mets | New York Mets signed free agent CF Albert Almora Jr.. |
| Feb 10, 2021 | Signed as free agent | Albert Almora Jr. | — | New York Mets | New York Mets signed free agent CF Albert Almora Jr.. |
| Feb 10, 2021 | Signed as free agent | Darren O'Day | — | New York Yankees | New York Yankees signed free agent P Darren O'Day. |
| Feb 10, 2021 | Signed as free agent | Mike Foltynewicz | — | Texas Rangers | Texas Rangers signed free agent P Mike Foltynewicz. |
| Feb 10, 2021 | Signed as free agent | Didi Gregorius | — | Philadelphia Phillies | Philadelphia Phillies signed free agent SS Didi Gregorius. |
| Feb 10, 2021 | Signed as free agent | Darren O'Day | — | New York Yankees | New York Yankees signed free agent RHP Darren O'Day. |
| Feb 10, 2021 | Signed as free agent | Albert Almora Jr. | — | New York Mets | New York Mets signed free agent CF Albert Almora Jr.. |
| Feb 10, 2021 | Signed as free agent | Albert Almora Jr. | — | New York Mets | New York Mets signed free agent CF Albert Almora Jr.. |
| Feb 9, 2021 | Signed as free agent | JT Chargois | — | Seattle Mariners | Seattle Mariners signed free agent RHP JT Chargois to a minor league contract and invited him to spring training. |
| Feb 9, 2021 | Signed as free agent | Chris Archer | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP Chris Archer. |
| Feb 9, 2021 | Signed as free agent | Taylor Guerrieri | — | Seattle Mariners | Seattle Mariners signed free agent RHP Taylor Guerrieri to a minor league contract and invited him to spring training. |
| Feb 9, 2021 | Signed as free agent | Steve Cishek | — | Houston Astros | Houston Astros signed free agent RHP Steve Cishek to a minor league contract and invited him to spring training. |
| Feb 9, 2021 | Signed as free agent | Nate Jones | — | Atlanta Braves | Atlanta Braves signed free agent RHP Nate Jones to a minor league contract and invited him to spring training. |
| Feb 9, 2021 | Signed as free agent | Matt Gage | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent LHP Matt Gage to a minor league contract. |
| Feb 9, 2021 | Signed as free agent | Taylor Guerrieri | — | Seattle Mariners | Seattle Mariners signed free agent RHP Taylor Guerrieri to a minor league contract and invited him to spring training. |
| Feb 9, 2021 | Signed as free agent | JT Chargois | — | Seattle Mariners | Seattle Mariners signed free agent RHP JT Chargois to a minor league contract and invited him to spring training. |
| Feb 9, 2021 | Signed as free agent | Taylor Guerrieri | — | Seattle Mariners | Seattle Mariners signed free agent P Taylor Guerrieri. |
| Feb 9, 2021 | Signed as free agent | JT Chargois | — | Seattle Mariners | Seattle Mariners signed free agent P JT Chargois. |
| Feb 9, 2021 | Signed as free agent | Yeison Vargas | — | Kansas City Royals | Kansas City Royals signed free agent SS Yeison Vargas. |
| Feb 9, 2021 | Signed as free agent | Yadier Molina | — | St. Louis Cardinals | St. Louis Cardinals signed free agent C Yadier Molina. |
| Feb 8, 2021 | Signed as free agent | Sean Doolittle | — | Cincinnati Reds | Cincinnati Reds signed free agent LHP Sean Doolittle. |
| Feb 8, 2021 | Signed as free agent | Chase Anderson | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RHP Chase Anderson. |
| Feb 8, 2021 | Trade | Aaron Slegers | Tampa Bay Rays | Los Angeles Angels | Tampa Bay Rays traded RHP Aaron Slegers to Los Angeles Angels for Player To Be Named Later. |
| Feb 8, 2021 | Signed as free agent | Drew Maggi | — | Minnesota Twins | Minnesota Twins signed free agent 3B Drew Maggi to a minor league contract. |
| Feb 8, 2021 | Signed as free agent | Brad Markey | — | Detroit Tigers | Detroit Tigers signed free agent RHP Brad Markey to a minor league contract. |
| Feb 8, 2021 | Signed as free agent | Pedro Payano | — | Detroit Tigers | Detroit Tigers signed free agent RHP Pedro Payano to a minor league contract. |
| Feb 8, 2021 | Signed as free agent | Drew Maggi | — | Minnesota Twins | Minnesota Twins signed free agent 3B Drew Maggi to a minor league contract. |
| Feb 8, 2021 | Signed as free agent | Sean Doolittle | — | Cincinnati Reds | Cincinnati Reds signed free agent LHP Sean Doolittle. |
| Feb 8, 2021 | Signed as free agent | Yosmi Fernandez | — | Kansas City Royals | Kansas City Royals signed free agent SS Yosmi Fernandez. |
| Feb 8, 2021 | Signed as free agent | Drew Maggi | — | Minnesota Twins | Minnesota Twins signed free agent SS Drew Maggi. |
| Feb 8, 2021 | Signed as free agent | Edwin Rodriguez | — | Kansas City Royals | Kansas City Royals signed free agent P Edwin Rodriguez. |
| Feb 8, 2021 | Signed as free agent | Chase Anderson | — | Philadelphia Phillies | Philadelphia Phillies signed free agent P Chase Anderson. |
| Feb 8, 2021 | Signed as free agent | Sean Doolittle | — | Cincinnati Reds | Cincinnati Reds signed free agent P Sean Doolittle. |
| Feb 8, 2021 | Signed as free agent | Chase Anderson | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RHP Chase Anderson. |
| Feb 8, 2021 | Signed as free agent | Sean Doolittle | — | Cincinnati Reds | Cincinnati Reds signed free agent LHP Sean Doolittle. |
| Feb 7, 2021 | Signed as free agent | Chasen Shreve | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent LHP Chasen Shreve to a minor league contract and invited him to spring training. |
| Feb 7, 2021 | Signed as free agent | Chasen Shreve | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent P Chasen Shreve. |
| Feb 6, 2021 | Trade | Khris Davis | Athletics | Texas Rangers | Oakland Athletics traded LF Khris Davis, C Jonah Heim and RHP Dane Acker to Texas Rangers for SS Elvis Andrus, C Aramis Garcia and cash. |
| Feb 6, 2021 | Signed as free agent | Joakim Soria | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Joakim Soria. |
| Feb 6, 2021 | Signed as free agent | Ryder Jones | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent 3B Ryder Jones to a minor league contract. |
| Feb 6, 2021 | Signed as free agent | Zach Lee | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Zach Lee to a minor league contract. |
| Feb 6, 2021 | Signed as free agent | James Sherfy | — | San Francisco Giants | San Francisco Giants signed free agent RHP James Sherfy to a minor league contract and invited him to spring training. |
| Feb 6, 2021 | Signed as free agent | Dugan Darnell | — | Colorado Rockies | Colorado Rockies signed free agent RHP Dugan Darnell to a minor league contract. |
| Feb 6, 2021 | Signed as free agent | James Sherfy | — | San Francisco Giants | San Francisco Giants signed free agent P James Sherfy. |
| Feb 6, 2021 | Signed as free agent | Fidel Montero | — | New York Yankees | New York Yankees signed free agent CF Fidel Montero. |
| Feb 5, 2021 | Signed as free agent | Kolten Wong | — | Milwaukee Brewers | Milwaukee Brewers signed free agent 2B Kolten Wong. |
| Feb 5, 2021 | Signed as free agent | Hanser Alberto | — | Kansas City Royals | Kansas City Royals signed free agent 2B Hanser Alberto to a minor league contract and invited him to spring training. |
| Feb 5, 2021 | Signed as free agent | Jonathan Schoop | — | Detroit Tigers | Detroit Tigers signed free agent 2B Jonathan Schoop. |
| Feb 5, 2021 | Signed as free agent | Bryant Mendez | — | Seattle Mariners | Seattle Mariners signed free agent SS Bryant Mendez to a minor league contract. |
| Feb 5, 2021 | Signed as free agent | Joc Pederson | — | Chicago Cubs | Chicago Cubs signed free agent LF Joc Pederson. |
| Feb 5, 2021 | Signed as free agent | Trevor Williams | — | Chicago Cubs | Chicago Cubs signed free agent RHP Trevor Williams. |
| Feb 5, 2021 | Signed as free agent | Andrew Chafin | — | Chicago Cubs | Chicago Cubs signed free agent LHP Andrew Chafin. |
| Feb 5, 2021 | Signed as free agent | Marcell Ozuna | — | Atlanta Braves | Atlanta Braves signed free agent LF Marcell Ozuna. |
| Feb 5, 2021 | Signed as free agent | Gleiner Diaz | — | Seattle Mariners | Seattle Mariners signed free agent RHP Gleiner Diaz to a minor league contract. |
| Feb 5, 2021 | Signed as free agent | Juan Pinto | — | Seattle Mariners | Seattle Mariners signed free agent LHP Juan Pinto to a minor league contract. |
| Feb 5, 2021 | Signed as free agent | Luis Bolivar | — | Seattle Mariners | Seattle Mariners signed free agent OF Luis Bolivar to a minor league contract. |
| Feb 5, 2021 | Signed as free agent | Roiber Talavera | — | Seattle Mariners | Seattle Mariners signed free agent RHP Roiber Talavera to a minor league contract. |
| Feb 5, 2021 | Signed as free agent | Ricardo Cova | — | Seattle Mariners | Seattle Mariners signed free agent SS Ricardo Cova to a minor league contract. |
| Feb 5, 2021 | Signed as free agent | Aneury Lora | — | Seattle Mariners | Seattle Mariners signed free agent RHP Aneury Lora to a minor league contract. |
| Feb 5, 2021 | Signed as free agent | Gabriel Gonzalez | — | Seattle Mariners | Seattle Mariners signed free agent OF Gabriel Gonzalez to a minor league contract. |
| Feb 5, 2021 | Signed as free agent | Nelson Cruz | — | Minnesota Twins | Minnesota Twins signed free agent DH Nelson Cruz. |
| Feb 5, 2021 | Signed as free agent | Jefferson Pena | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent SS Jefferson Pena to a minor league contract. |
| Feb 5, 2021 | Signed as free agent | Chandler Shepherd | — | Minnesota Twins | Minnesota Twins signed free agent RHP Chandler Shepherd to a minor league contract. |
| Feb 5, 2021 | Signed as free agent | Kyle Barraclough | — | New York Yankees | New York Yankees signed free agent RHP Kyle Barraclough to a minor league contract and invited him to spring training. |
| Feb 5, 2021 | Signed as free agent | Hanser Alberto | — | Kansas City Royals | Kansas City Royals signed free agent 2B Hanser Alberto to a minor league contract and invited him to spring training. |
| Feb 5, 2021 | Signed as free agent | Jose Fernandez | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent SS Jose Fernandez to a minor league contract. |
| Feb 5, 2021 | Signed as free agent | Kyle Barraclough | — | New York Yankees | New York Yankees signed free agent P Kyle Barraclough. |
| Feb 5, 2021 | Signed as free agent | Elvis Saba | — | San Diego Padres | San Diego Padres signed free agent P Elvis Saba. |
| Feb 5, 2021 | Signed as free agent | Yilber Díaz | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent P Yilber Diaz. |
| Feb 5, 2021 | Signed as free agent | Miguel Mendez | — | San Diego Padres | San Diego Padres signed free agent P Miguel Mendez. |
| Feb 5, 2021 | Signed as free agent | Jonathan Nava | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent C Jonathan Nava. |
| Feb 5, 2021 | Signed as free agent | Jose Aguirre | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent P Jose Aguirre. |
| Feb 5, 2021 | Signed as free agent | Luis Acosta | — | San Diego Padres | San Diego Padres signed free agent P Luis Acosta. |
| Feb 5, 2021 | Signed as free agent | Kenny Castillo | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent C Kenny Castillo. |
| Feb 5, 2021 | Signed as free agent | Nixon Parra | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent P Nixon Parra. |
| Feb 5, 2021 | Signed as free agent | Deyer Zapata | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent P Deyer Zapata. |
| Feb 5, 2021 | Signed as free agent | Fernando Alvarado | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent 2B Fernando Alvarado. |
| Feb 5, 2021 | Signed as free agent | Anderson Colmenarez | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent SS Anderson Colmenarez. |
| Feb 5, 2021 | Signed as free agent | Felix Nunez | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent P Felix Nunez. |
| Feb 5, 2021 | Signed as free agent | Nelson Cruz | — | Minnesota Twins | Minnesota Twins signed free agent DH Nelson Cruz. |
| Feb 5, 2021 | Signed as free agent | Jonathan Schoop | — | Detroit Tigers | Detroit Tigers signed free agent 2B Jonathan Schoop. |
| Feb 5, 2021 | Signed as free agent | Marcell Ozuna | — | Atlanta Braves | Atlanta Braves signed free agent CF Marcell Ozuna. |
| Feb 5, 2021 | Signed as free agent | Joc Pederson | — | Chicago Cubs | Chicago Cubs signed free agent CF Joc Pederson. |
| Feb 5, 2021 | Signed as free agent | Trevor Williams | — | Chicago Cubs | Chicago Cubs signed free agent P Trevor Williams. |
| Feb 5, 2021 | Signed as free agent | Andrew Chafin | — | Chicago Cubs | Chicago Cubs signed free agent P Andrew Chafin. |
| Feb 5, 2021 | Signed as free agent | Jonathan Schoop | — | Detroit Tigers | Detroit Tigers signed free agent 2B Jonathan Schoop. |
| Feb 5, 2021 | Signed as free agent | Nelson Cruz | — | Minnesota Twins | Minnesota Twins signed free agent DH Nelson Cruz. |
| Feb 5, 2021 | Signed as free agent | Trevor Williams | — | Chicago Cubs | Chicago Cubs signed free agent RHP Trevor Williams. |
| Feb 5, 2021 | Signed as free agent | Joc Pederson | — | Chicago Cubs | Chicago Cubs signed free agent CF Joc Pederson. |
| Feb 5, 2021 | Signed as free agent | Andrew Chafin | — | Chicago Cubs | Chicago Cubs signed free agent LHP Andrew Chafin. |
| Feb 5, 2021 | Signed as free agent | Marcell Ozuna | — | Atlanta Braves | Atlanta Braves signed free agent CF Marcell Ozuna. |
| Feb 5, 2021 | Signed as free agent | Unnamed | — | Detroit Tigers | Detroit Tigers signed free agent 2B Jonathan Schoop, , and. |
| Feb 4, 2021 | Signed as free agent | Mike Freeman | — | Cleveland Guardians | Cleveland Indians signed free agent 2B Mike Freeman to a minor league contract and invited him to spring training. |
| Feb 4, 2021 | Signed as free agent | Eddie Rosario | — | Cleveland Guardians | Cleveland Indians signed free agent LF Eddie Rosario. |
| Feb 4, 2021 | Signed as free agent | Tommy La Stella | — | San Francisco Giants | San Francisco Giants signed free agent 2B Tommy La Stella. |
| Feb 4, 2021 | Signed as free agent | Nick Vincent | — | Texas Rangers | Texas Rangers signed free agent RHP Nick Vincent to a minor league contract and invited him to spring training. |
| Feb 4, 2021 | Trade | Dexter Fowler | St. Louis Cardinals | Los Angeles Angels | St. Louis Cardinals traded RF Dexter Fowler to Los Angeles Angels for Player To Be Named Later. |
| Feb 4, 2021 | Trade | LaMonte Wade Jr. | Minnesota Twins | San Francisco Giants | Minnesota Twins traded LaMonte Wade Jr to San Francisco Giants for RHP Shaun Anderson. |
| Feb 4, 2021 | Signed as free agent | Miguel Lopez | — | Cleveland Guardians | Cleveland Indians signed free agent SS Miguel Lopez to a minor league contract. |
| Feb 4, 2021 | Signed as free agent | Emerson Purroy | — | Cleveland Guardians | Cleveland Indians signed free agent SS Emerson Purroy to a minor league contract. |
| Feb 4, 2021 | Signed as free agent | Zack Littell | — | San Francisco Giants | San Francisco Giants signed free agent RHP Zack Littell to a minor league contract and invited him to spring training. |
| Feb 4, 2021 | Signed as free agent | Humberto Arteaga | — | Washington Nationals | Washington Nationals signed free agent 3B Humberto Arteaga to a minor league contract. |
| Feb 4, 2021 | Signed as free agent | Tommy La Stella | — | San Francisco Giants | San Francisco Giants signed free agent 2B Tommy La Stella. |
| Feb 4, 2021 | Trade | Shaun Anderson | — | Minnesota Twins | traded to Minnesota Twins for . |
| Feb 4, 2021 | Signed as free agent | Zack Littell | — | San Francisco Giants | San Francisco Giants signed free agent P Zack Littell. |
| Feb 4, 2021 | Signed as free agent | Eddie Rosario | — | Cleveland Guardians | Cleveland Indians signed free agent LF Eddie Rosario. |
| Feb 4, 2021 | Signed as free agent | Tommy La Stella | — | San Francisco Giants | San Francisco Giants signed free agent 2B Tommy La Stella. |
| Feb 4, 2021 | Signed as free agent | Tommy La Stella | — | San Francisco Giants | San Francisco Giants signed free agent 2B Tommy La Stella. |
| Feb 4, 2021 | Signed as free agent | Eddie Rosario | — | Cleveland Guardians | Cleveland Indians signed free agent LF Eddie Rosario. |
| Feb 3, 2021 | Signed as free agent | Nicky Delmonico | — | Cincinnati Reds | Cincinnati Reds signed free agent OF Nicky Delmonico to a minor league contract and invited him to spring training. |
| Feb 3, 2021 | Signed as free agent | Matt Moore | — | Philadelphia Phillies | Philadelphia Phillies signed free agent LHP Matt Moore. |
| Feb 3, 2021 | Signed as free agent | Alex Avila | — | Washington Nationals | Washington Nationals signed free agent C Alex Avila. |
| Feb 3, 2021 | Signed as free agent | Garrett Richards | — | Boston Red Sox | Boston Red Sox signed free agent RHP Garrett Richards. |
| Feb 3, 2021 | Signed as free agent | Bryan Shaw | — | Cleveland Guardians | Cleveland Indians signed free agent RHP Bryan Shaw to a minor league contract and invited him to spring training. |
| Feb 3, 2021 | Signed as free agent | DJ Johnson | — | Cleveland Guardians | Cleveland Indians signed free agent RHP DJ Johnson to a minor league contract and invited him to spring training. |
| Feb 3, 2021 | Signed as free agent | Francisco Liriano | — | Toronto Blue Jays | Toronto Blue Jays signed free agent LHP Francisco Liriano to a minor league contract and invited him to spring training. |
| Feb 3, 2021 | Signed as free agent | Félix Hernández | — | Baltimore Orioles | Baltimore Orioles signed free agent RHP Felix Hernandez to a minor league contract and invited him to spring training. |
| Feb 3, 2021 | Signed as free agent | Seth Mejias-Brean | — | Baltimore Orioles | Baltimore Orioles signed free agent 3B Seth Mejias-Brean to a minor league contract. |
| Feb 3, 2021 | Signed as free agent | Konner Wade | — | Baltimore Orioles | Baltimore Orioles signed free agent RHP Konner Wade to a minor league contract. |
| Feb 3, 2021 | Signed as free agent | Wade LeBlanc | — | Baltimore Orioles | Baltimore Orioles signed free agent LHP Wade LeBlanc to a minor league contract and invited him to spring training. |
| Feb 3, 2021 | Signed as free agent | Hernán Pérez | — | Washington Nationals | Washington Nationals signed free agent 2B Hernan Perez to a minor league contract and invited him to spring training. |
| Feb 3, 2021 | Signed as free agent | Garrett Richards | — | Boston Red Sox | Boston Red Sox signed free agent RHP Garrett Richards. |
| Feb 3, 2021 | Signed as free agent | Wade LeBlanc | — | Baltimore Orioles | Baltimore Orioles signed free agent LHP Wade LeBlanc to a minor league contract and invited him to spring training. |
| Feb 3, 2021 | Signed as free agent | Félix Hernández | — | Baltimore Orioles | Baltimore Orioles signed free agent RHP Felix Hernandez to a minor league contract and invited him to spring training. |
| Feb 3, 2021 | Signed as free agent | Seth Mejias-Brean | — | Baltimore Orioles | Baltimore Orioles signed free agent 3B Seth Mejias-Brean to a minor league contract. |
| Feb 3, 2021 | Signed as free agent | Konner Wade | — | Baltimore Orioles | Baltimore Orioles signed free agent RHP Konner Wade to a minor league contract. |
| Feb 3, 2021 | Signed as free agent | Bryan Shaw | — | Cleveland Guardians | Cleveland Indians signed free agent P Bryan Shaw. |
| Feb 3, 2021 | Signed as free agent | DJ Johnson | — | Cleveland Guardians | Cleveland Indians signed free agent P DJ Johnson. |
| Feb 3, 2021 | Signed as free agent | Nicky Delmonico | — | Cincinnati Reds | Cincinnati Reds signed free agent LF Nicky Delmonico. |
| Feb 3, 2021 | Signed as free agent | Seth Mejias-Brean | — | Baltimore Orioles | Baltimore Orioles signed free agent 3B Seth Mejias-Brean. |
| Feb 3, 2021 | Signed as free agent | Konner Wade | — | Baltimore Orioles | Baltimore Orioles signed free agent P Konner Wade. |
| Feb 3, 2021 | Signed as free agent | Allan de San Miguel | — | Kansas City Royals | Kansas City Royals signed free agent C Allan de San Miguel. |
| Feb 3, 2021 | Signed as free agent | Matt Moore | — | Philadelphia Phillies | Philadelphia Phillies signed free agent P Matt Moore. |
| Feb 3, 2021 | Signed as free agent | Garrett Richards | — | Boston Red Sox | Boston Red Sox signed free agent P Garrett Richards. |
| Feb 3, 2021 | Signed as free agent | Garrett Richards | — | Boston Red Sox | Boston Red Sox signed free agent P Garrett Richards. |
| Feb 3, 2021 | Signed as free agent | Matt Moore | — | Philadelphia Phillies | Philadelphia Phillies signed free agent LHP Matt Moore. |
| Feb 2, 2021 | Signed as free agent | Carlos Pérez | — | Athletics | Oakland Athletics signed free agent C Carlos Perez to a minor league contract and invited him to spring training. |
| Feb 2, 2021 | Signed as free agent | Deolis Guerra | — | Athletics | Oakland Athletics signed free agent RHP Deolis Guerra to a minor league contract and invited him to spring training. |
| Feb 2, 2021 | Signed as free agent | Enrique Hernández | — | Boston Red Sox | Boston Red Sox signed free agent 2B Enrique Hernandez. |
| Feb 2, 2021 | Signed as free agent | Spencer Patton | — | Texas Rangers | Texas Rangers signed free agent RHP Spencer Patton to a minor league contract and invited him to spring training. |
| Feb 2, 2021 | Trade | Jahmai Jones | Los Angeles Angels | Baltimore Orioles | Baltimore Orioles traded RHP Alex Cobb and cash to Los Angeles Angels for 2B Jahmai Jones. |
| Feb 2, 2021 | Signed as free agent | Dusten Knight | — | Baltimore Orioles | Baltimore Orioles signed free agent RHP Dusten Knight to a minor league contract. |
| Feb 2, 2021 | Signed as free agent | Marcus Evey | — | Chicago White Sox | Chicago White Sox signed free agent RHP Marcus Evey to a minor league contract. |
| Feb 2, 2021 | Signed as free agent | Henri Lartigue | — | Chicago White Sox | Chicago White Sox signed free agent C Henri Lartigue to a minor league contract. |
| Feb 2, 2021 | Signed as free agent | Asher Wojciechowski | — | New York Yankees | New York Yankees signed free agent RHP Asher Wojciechowski to a minor league contract and invited him to spring training. |
| Feb 2, 2021 | Signed as free agent | Carl Edwards Jr. | — | Atlanta Braves | Atlanta Braves signed free agent RHP Carl Edwards Jr. to a minor league contract and invited him to spring training. |
| Feb 2, 2021 | Signed as free agent | Malquin Canelo | — | Baltimore Orioles | Baltimore Orioles signed free agent SS Malquin Canelo to a minor league contract. |
| Feb 2, 2021 | Signed as free agent | Spenser Watkins | — | Baltimore Orioles | Baltimore Orioles signed free agent RHP Spenser Watkins to a minor league contract. |
| Feb 2, 2021 | Signed as free agent | Sal Biasi | — | Chicago White Sox | Chicago White Sox signed free agent RHP Sal Biasi to a minor league contract. |
| Feb 2, 2021 | Signed as free agent | Junior Guerra | — | Los Angeles Angels | Los Angeles Angels signed free agent RHP Junior Guerra to a minor league contract and invited him to spring training. |
| Feb 2, 2021 | Signed as free agent | Blaine Hardy | — | Milwaukee Brewers | Milwaukee Brewers signed free agent LHP Blaine Hardy to a minor league contract and invited him to spring training. |
| Feb 2, 2021 | Signed as free agent | Connor Overton | — | Toronto Blue Jays | Toronto Blue Jays signed free agent RHP Connor Overton to a minor league contract. |
| Feb 2, 2021 | Signed as free agent | Yemal Flores | — | Philadelphia Phillies | Philadelphia Phillies signed free agent OF Yemal Flores to a minor league contract. |
| Feb 2, 2021 | Signed as free agent | Leonardo Rondon | — | Philadelphia Phillies | Philadelphia Phillies signed free agent IF Leonardo Rondon to a minor league contract. |
| Feb 2, 2021 | Signed as free agent | Jorge Garcia | — | Philadelphia Phillies | Philadelphia Phillies signed free agent OF Jorge Garcia to a minor league contract. |
| Feb 2, 2021 | Signed as free agent | Rickardo Perez | — | Philadelphia Phillies | Philadelphia Phillies signed free agent C Rickardo Perez to a minor league contract. |
| Feb 2, 2021 | Signed as free agent | Alexis Garibaldi | — | Philadelphia Phillies | Philadelphia Phillies signed free agent LHP Jesus Garibaldi to a minor league contract. |
| Feb 2, 2021 | Signed as free agent | Ji Tae Lee | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RHP Ji Tae Lee to a minor league contract. |
| Feb 2, 2021 | Signed as free agent | Ender Paz | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RHP Ender Paz to a minor league contract. |
| Feb 2, 2021 | Signed as free agent | Carlos Millan | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RHP Carlos Millan to a minor league contract. |
| Feb 2, 2021 | Signed as free agent | Saul Teran | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RHP Saul Teran to a minor league contract. |
| Feb 2, 2021 | Signed as free agent | Solardo Rodriguez | — | Philadelphia Phillies | Philadelphia Phillies signed free agent C Solardo Rodriguez to a minor league contract. |
| Feb 2, 2021 | Signed as free agent | Deivi Cabrera | — | Philadelphia Phillies | Philadelphia Phillies signed free agent IF Deivi Cabrera to a minor league contract. |
| Feb 2, 2021 | Signed as free agent | Yoangel Ramos | — | Philadelphia Phillies | Philadelphia Phillies signed free agent SS Yoangel Ramos to a minor league contract. |
| Feb 2, 2021 | Signed as free agent | Juan Melendez | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RHP Juan Melendez to a minor league contract. |
| Feb 2, 2021 | Signed as free agent | Danyony Pulido | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RHP Danyony Pulido to a minor league contract. |
| Feb 2, 2021 | Signed as free agent | Julio Heureaux | — | Philadelphia Phillies | Philadelphia Phillies signed free agent SS Julio Heureaux to a minor league contract. |
| Feb 2, 2021 | Signed as free agent | Dervin Andrade | — | Philadelphia Phillies | Philadelphia Phillies signed free agent C Dervin Andrade to a minor league contract. |
| Feb 2, 2021 | Signed as free agent | Raylin Heredia | — | Philadelphia Phillies | Philadelphia Phillies signed free agent OF Raylin Heredia to a minor league contract. |
| Feb 2, 2021 | Signed as free agent | Marco Soto | — | Philadelphia Phillies | Philadelphia Phillies signed free agent IF Marco Soto to a minor league contract. |
| Feb 2, 2021 | Signed as free agent | Yemil Rosario | — | Philadelphia Phillies | Philadelphia Phillies signed free agent SS Yemil Rosario to a minor league contract. |
| Feb 2, 2021 | Signed as free agent | Alfredo Alderete | — | Philadelphia Phillies | Philadelphia Phillies signed free agent SS Alfredo Alderete to a minor league contract. |
| Feb 2, 2021 | Signed as free agent | Daniel Mejia | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RHP Daniel Mejia to a minor league contract. |
| Feb 2, 2021 | Signed as free agent | Héctor Rondón | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RHP Hector Rondon to a minor league contract and invited him to spring training. |
| Feb 2, 2021 | Signed as free agent | Nathan Patterson | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Nathan Patterson to a minor league contract. |
| Feb 2, 2021 | Signed as free agent | Hunter Strickland | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP Hunter Strickland to a minor league contract. |
| Feb 2, 2021 | Signed as free agent | Keon Broxton | — | Minnesota Twins | Minnesota Twins signed free agent OF Keon Broxton to a minor league contract and invited him to spring training. |
| Feb 2, 2021 | Signed as free agent | Keon Broxton | — | Minnesota Twins | Minnesota Twins signed free agent OF Keon Broxton to a minor league contract and invited him to spring training. |
| Feb 2, 2021 | Signed as free agent | Blaine Hardy | — | Milwaukee Brewers | Milwaukee Brewers signed free agent LHP Blaine Hardy to a minor league contract and invited him to spring training. |
| Feb 2, 2021 | Signed as free agent | Junior Guerra | — | Los Angeles Angels | Los Angeles Angels signed free agent RHP Junior Guerra to a minor league contract and invited him to spring training. |
| Feb 2, 2021 | Signed as free agent | Spenser Watkins | — | Baltimore Orioles | Baltimore Orioles signed free agent RHP Spenser Watkins to a minor league contract. |
| Feb 2, 2021 | Trade | Jahmai Jones | — | Baltimore Orioles | traded to Baltimore Orioles for . |
| Feb 2, 2021 | Signed as free agent | Spencer Patton | — | Texas Rangers | Texas Rangers signed free agent P Spencer Patton. |
| Feb 2, 2021 | Signed as free agent | Carlos Pérez | — | Athletics | Oakland Athletics signed free agent C Carlos Perez. |
| Feb 2, 2021 | Signed as free agent | Asher Wojciechowski | — | New York Yankees | New York Yankees signed free agent P Asher Wojciechowski. |
| Feb 2, 2021 | Signed as free agent | Keon Broxton | — | Minnesota Twins | Minnesota Twins signed free agent CF Keon Broxton. |
| Feb 2, 2021 | Signed as free agent | Blaine Hardy | — | Milwaukee Brewers | Milwaukee Brewers signed free agent P Blaine Hardy. |
| Feb 2, 2021 | Signed as free agent | Spenser Watkins | — | Baltimore Orioles | Baltimore Orioles signed free agent P Spenser Watkins. |
| Feb 2, 2021 | Signed as free agent | Josue Romero | — | Texas Rangers | Texas Rangers signed free agent C Josue Romero. |
| Feb 2, 2021 | Signed as free agent | Ruben Gil | — | Atlanta Braves | Atlanta Braves signed free agent P Ruben Gil. |
| Feb 2, 2021 | Signed as free agent | Jeremy De Los Santos | — | Atlanta Braves | Atlanta Braves signed free agent P Jeremy De Los Santos. |
| Feb 2, 2021 | Signed as free agent | Yorlis Lendor | — | Atlanta Braves | Atlanta Braves signed free agent OF Yorlis Lendor. |
| Feb 2, 2021 | Signed as free agent | Joe Jones | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent P Joe Jones. |
| Feb 2, 2021 | Signed as free agent | Enrique Hernández | — | Boston Red Sox | Boston Red Sox signed free agent CF Enrique Hernandez. |
| Feb 2, 2021 | Signed as free agent | Enrique Hernández | — | Boston Red Sox | Boston Red Sox signed free agent CF Enrique Hernandez. |
| Feb 1, 2021 | Trade | Federico Polanco | New York Mets | Miami Marlins | Miami Marlins traded RHP Jordan Yamamoto to New York Mets for SS Federico Polanco. |
| Feb 1, 2021 | Signed as free agent | Sam Gaviglio | — | Texas Rangers | Texas Rangers signed free agent RHP Sam Gaviglio to a minor league contract and invited him to spring training. |
| Feb 1, 2021 | Signed as free agent | Delino DeShields | — | Texas Rangers | Texas Rangers signed free agent CF Delino DeShields to a minor league contract and invited him to spring training. |
| Feb 1, 2021 | Signed as free agent | Adrian De Horta | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP Adrian De Horta to a minor league contract and invited him to spring training. |
| Feb 1, 2021 | Signed as free agent | Yacksel Ríos | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP Yacksel Rios to a minor league contract and invited him to spring training. |
| Feb 1, 2021 | Signed as free agent | Carlos Rodón | — | Chicago White Sox | Chicago White Sox signed free agent LHP Carlos Rodon. |
| Feb 1, 2021 | Signed as free agent | Steven Souza Jr. | — | Houston Astros | Houston Astros signed free agent RF Steven Souza Jr. to a minor league contract and invited him to spring training. |
| Feb 1, 2021 | Trade | Elehuris Montero | St. Louis Cardinals | Colorado Rockies | Colorado Rockies traded 3B Nolan Arenado and cash to St. Louis Cardinals for LHP Austin Gomber, 3B Elehuris Montero, RHP Tony Locey, SS Mateo Gil and RHP Jake Sommers. |
| Feb 1, 2021 | Signed as free agent | Delino DeShields | — | Texas Rangers | Texas Rangers signed free agent CF Delino DeShields. |
| Feb 1, 2021 | Signed as free agent | Sam Gaviglio | — | Texas Rangers | Texas Rangers signed free agent P Sam Gaviglio. |
| Feb 1, 2021 | Signed as free agent | Yacksel Ríos | — | Tampa Bay Rays | Tampa Bay Rays signed free agent P Yacksel Rios. |
| Feb 1, 2021 | Signed as free agent | Adrian De Horta | — | Tampa Bay Rays | Tampa Bay Rays signed free agent P Adrian De Horta. |
| Feb 1, 2021 | Signed as free agent | Jaime Schultz | — | Seattle Mariners | Seattle Mariners signed free agent P Jaime Schultz. |
| Feb 1, 2021 | Signed as free agent | Derlin Figueroa | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent SS Derlin Figueroa. |
| Feb 1, 2021 | Signed as free agent | Yan Mago | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent P Yan Mago. |
| Feb 1, 2021 | Signed as free agent | Carlos Rodón | — | Chicago White Sox | Chicago White Sox signed free agent P Carlos Rodon. |
| Feb 1, 2021 | Signed as free agent | Carlos Rodón | — | Chicago White Sox | Chicago White Sox signed free agent P Carlos Rodon. |
| Jan 31, 2021 | Signed as free agent | Andrelton Simmons | — | Minnesota Twins | Minnesota Twins signed free agent SS Andrelton Simmons. |
| Jan 30, 2021 | Signed as free agent | Marcus Semien | — | Toronto Blue Jays | Toronto Blue Jays signed free agent SS Marcus Semien. |
| Jan 30, 2021 | Trade | Cole Irvin | Philadelphia Phillies | Athletics | Philadelphia Phillies traded LHP Cole Irvin to Oakland Athletics for cash. |
| Jan 30, 2021 | Trade | Kyle Holder | Philadelphia Phillies | Cincinnati Reds | Cincinnati Reds traded cash to Philadelphia Phillies for SS Kyle Holder. |
| Jan 30, 2021 | Signed as free agent | Aaron Loup | — | New York Mets | New York Mets signed free agent LHP Aaron Loup. |
| Jan 30, 2021 | Signed as free agent | Omar Hernandez | — | Baltimore Orioles | Baltimore Orioles signed free agent P Omar Hernandez. |
| Jan 30, 2021 | Signed as free agent | Marcus Semien | — | Toronto Blue Jays | Toronto Blue Jays signed free agent SS Marcus Semien. |
| Jan 30, 2021 | Signed as free agent | Aaron Loup | — | New York Mets | New York Mets signed free agent P Aaron Loup. |
| Jan 30, 2021 | Signed as free agent | Aaron Loup | — | New York Mets | New York Mets signed free agent P Aaron Loup. |
| Jan 30, 2021 | Signed as free agent | Marcus Semien | — | Toronto Blue Jays | Toronto Blue Jays signed free agent SS Marcus Semien. |
| Jan 30, 2021 | Signed as free agent | Aaron Loup | — | New York Mets | New York Mets signed free agent LHP Aaron Loup. |
| Jan 30, 2021 | Signed as free agent | Aaron Loup | — | New York Mets | New York Mets signed free agent LHP Aaron Loup. |
| Jan 29, 2021 | Signed as free agent | Iván Nova | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RHP Ivan Nova to a minor league contract and invited him to spring training. |
| Jan 29, 2021 | Signed as free agent | Adam Wainwright | — | St. Louis Cardinals | St. Louis Cardinals signed free agent RHP Adam Wainwright. |
| Jan 29, 2021 | Signed as free agent | Wilson Ramos | — | Detroit Tigers | Detroit Tigers signed free agent C Wilson Ramos. |
| Jan 29, 2021 | Signed as free agent | J.T. Realmuto | — | Philadelphia Phillies | Philadelphia Phillies signed free agent C J.T. Realmuto. |
| Jan 29, 2021 | Signed as free agent | Sebastian Ramirez | — | Kansas City Royals | Kansas City Royals signed free agent OF Sebastian Ramirez to a minor league contract. |
| Jan 29, 2021 | Signed as free agent | Jandel Sanchez | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent P Jandel Sanchez. |
| Jan 29, 2021 | Signed as free agent | Alfredo Zarraga | — | Chicago Cubs | Chicago Cubs signed free agent P Alfredo Zarraga. |
| Jan 29, 2021 | Signed as free agent | Eskoly De Jesus | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent OF Eskoly De Jesus. |
| Jan 29, 2021 | Signed as free agent | Jesus Suarez | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent P Jesus Suarez. |
| Jan 29, 2021 | Signed as free agent | Jesus Zabaleta | — | Miami Marlins | Miami Marlins signed free agent P Jesus Zabaleta. |
| Jan 29, 2021 | Signed as free agent | Adrian De Leon | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent C Adrian De Leon. |
| Jan 29, 2021 | Signed as free agent | J.T. Realmuto | — | Philadelphia Phillies | Philadelphia Phillies signed free agent C J.T. Realmuto. |
| Jan 29, 2021 | Signed as free agent | Wilson Ramos | — | Detroit Tigers | Detroit Tigers signed free agent C Wilson Ramos. |
| Jan 29, 2021 | Signed as free agent | Adam Wainwright | — | St. Louis Cardinals | St. Louis Cardinals signed free agent P Adam Wainwright. |
| Jan 29, 2021 | Signed as free agent | Wilson Ramos | — | Detroit Tigers | Detroit Tigers signed free agent C Wilson Ramos. |
| Jan 29, 2021 | Signed as free agent | Adam Wainwright | — | St. Louis Cardinals | St. Louis Cardinals signed free agent RHP Adam Wainwright. |
| Jan 29, 2021 | Signed as free agent | J.T. Realmuto | — | Philadelphia Phillies | Philadelphia Phillies signed free agent C J.T. Realmuto. |
| Jan 29, 2021 | Signed as free agent | César Hernández | — | Cleveland Guardians | Cleveland Indians signed free agent 2B Cesar Hernandez. |
| Jan 29, 2021 | Signed as free agent | Ryley Widell | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent LHP Ryley Widell to a minor league contract. |
| Jan 28, 2021 | Signed as free agent | Kohl Stewart | — | Chicago Cubs | Chicago Cubs signed free agent RHP Kohl Stewart. |
| Jan 28, 2021 | Signed as free agent | Blake Swihart | — | Washington Nationals | Washington Nationals signed free agent C Blake Swihart to a minor league contract. |
| Jan 28, 2021 | Signed as free agent | Yaqui Rivera | — | Miami Marlins | Miami Marlins signed free agent P Yaqui Rivera. |
| Jan 27, 2021 | Signed as free agent | Jon Lester | — | Washington Nationals | Washington Nationals signed free agent LHP Jon Lester. |
| Jan 27, 2021 | Signed as free agent | DJ LeMahieu | — | New York Yankees | New York Yankees signed free agent 2B DJ LeMahieu. |
| Jan 27, 2021 | Signed as free agent | Corey Kluber | — | New York Yankees | New York Yankees signed free agent RHP Corey Kluber. |
| Jan 27, 2021 | Signed as free agent | Jurickson Profar | — | San Diego Padres | San Diego Padres signed free agent LF Jurickson Profar. |
| Jan 27, 2021 | Trade | Steven Matz | New York Mets | Toronto Blue Jays | New York Mets traded LHP Steven Matz to Toronto Blue Jays for RHP Josh Winckowski, RHP Sean Reid-Foley and RHP Yennsy Diaz. |
| Jan 27, 2021 | Signed as free agent | Anthony Bass | — | Miami Marlins | Miami Marlins signed free agent RHP Anthony Bass. |
| Jan 27, 2021 | Signed as free agent | Karsen Lindell | — | Cincinnati Reds | Cincinnati Reds signed free agent RHP Karsen Lindell to a minor league contract. |
| Jan 27, 2021 | Signed as free agent | Anthony Bass | — | Miami Marlins | Miami Marlins signed free agent RHP Anthony Bass. |
| Jan 27, 2021 | Signed as free agent | Jurickson Profar | — | San Diego Padres | San Diego Padres signed free agent 3B Jurickson Profar. |
| Jan 27, 2021 | Signed as free agent | Anthony Bass | — | Miami Marlins | Miami Marlins signed free agent P Anthony Bass. |
| Jan 27, 2021 | Signed as free agent | DJ LeMahieu | — | New York Yankees | New York Yankees signed free agent 2B DJ LeMahieu. |
| Jan 27, 2021 | Signed as free agent | Corey Kluber | — | New York Yankees | New York Yankees signed free agent P Corey Kluber. |
| Jan 27, 2021 | Signed as free agent | Jurickson Profar | — | San Diego Padres | San Diego Padres signed free agent 3B Jurickson Profar. |
| Jan 27, 2021 | Signed as free agent | Corey Kluber | — | New York Yankees | New York Yankees signed free agent RHP Corey Kluber. |
| Jan 27, 2021 | Signed as free agent | DJ LeMahieu | — | New York Yankees | New York Yankees signed free agent 2B DJ LeMahieu. |
| Jan 27, 2021 | Signed as free agent | Anthony Bass | — | Miami Marlins | Miami Marlins signed free agent RHP Anthony Bass, and. |
| Jan 27, 2021 | Signed as free agent | DJ LeMahieu | — | New York Yankees | New York Yankees signed free agent 2B DJ LeMahieu. |
| Jan 27, 2021 | Signed as free agent | Alec Keller | — | Washington Nationals | Washington Nationals signed free agent LF Alec Keller to a minor league contract. |
| Jan 27, 2021 | Signed as free agent | DJ LeMahieu | — | New York Yankees | New York Yankees signed free agent 2B DJ LeMahieu. |
| Jan 27, 2021 | Signed as free agent | DJ LeMahieu | — | New York Yankees | New York Yankees signed free agent 2B DJ LeMahieu. |
| Jan 26, 2021 | Signed as free agent | Brad Hand | — | Washington Nationals | Washington Nationals signed free agent LHP Brad Hand. |
| Jan 26, 2021 | Signed as free agent | Freddy Galvis | — | Baltimore Orioles | Baltimore Orioles signed free agent SS Freddy Galvis. |
| Jan 26, 2021 | Signed as free agent | Ehire Adrianza | — | Atlanta Braves | Atlanta Braves signed free agent 3B Ehire Adrianza to a minor league contract and invited him to spring training. |
| Jan 26, 2021 | Signed as free agent | Freddy Galvis | — | Baltimore Orioles | Baltimore Orioles signed free agent SS Freddy Galvis. |
| Jan 26, 2021 | Signed as free agent | Cristian Rojas | — | Chicago Cubs | Chicago Cubs signed free agent P Cristian Rojas. |
| Jan 26, 2021 | Signed as free agent | Luis R. Reyes | — | Chicago Cubs | Chicago Cubs signed free agent P Luis Reyes. |
| Jan 26, 2021 | Signed as free agent | Jonaiker Sandoval | — | Baltimore Orioles | Baltimore Orioles signed free agent CF Jonaiker Sandoval. |
| Jan 26, 2021 | Signed as free agent | Freddy Galvis | — | Baltimore Orioles | Baltimore Orioles signed free agent SS Freddy Galvis. |
| Jan 26, 2021 | Signed as free agent | Freddy Galvis | — | Baltimore Orioles | Baltimore Orioles signed free agent SS Freddy Galvis. |
| Jan 26, 2021 | Signed as free agent | Freddy Galvis | — | Baltimore Orioles | Baltimore Orioles signed free agent SS Freddy Galvis. |
| Jan 25, 2021 | Trade | Frank German | New York Yankees | Boston Red Sox | New York Yankees traded RHP Adam Ottavino and RHP Frank German to Boston Red Sox for Player To Be Named Later. |
| Jan 25, 2021 | Signed as free agent | Joe Hudson | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent C Joe Hudson to a minor league contract and invited him to spring training. |
| Jan 25, 2021 | Signed as free agent | Michael Brantley | — | Houston Astros | Houston Astros signed free agent LF Michael Brantley. |
| Jan 25, 2021 | Signed as free agent | Walker Weickel | — | Cincinnati Reds | Cincinnati Reds signed free agent RHP Walker Weickel to a minor league contract. |
| Jan 25, 2021 | Signed as free agent | C.J. Hinojosa | — | Houston Astros | Houston Astros signed free agent SS C.J. Hinojosa to a minor league contract. |
| Jan 25, 2021 | Signed as free agent | Derek Holland | — | Detroit Tigers | Detroit Tigers signed free agent LHP Derek Holland to a minor league contract and invited him to spring training. |
| Jan 25, 2021 | Signed as free agent | Joe Hudson | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent C Joe Hudson. |
| Jan 25, 2021 | Signed as free agent | Derek Holland | — | Detroit Tigers | Detroit Tigers signed free agent P Derek Holland. |
| Jan 25, 2021 | Signed as free agent | Wilmer Bolivar | — | Chicago Cubs | Chicago Cubs signed free agent OF Wilmer Bolivar. |
| Jan 25, 2021 | Signed as free agent | Carlos Marcano | — | Detroit Tigers | Detroit Tigers signed free agent P Carlos Marcano. |
| Jan 25, 2021 | Signed as free agent | Norel González | — | Houston Astros | Houston Astros signed free agent OF Norel Gonzalez. |
| Jan 25, 2021 | Signed as free agent | Michael Brantley | — | Houston Astros | Houston Astros signed free agent LF Michael Brantley. |
| Jan 25, 2021 | Signed as free agent | Michael Brantley | — | Houston Astros | Houston Astros signed free agent LF Michael Brantley. |
| Jan 24, 2021 | Trade | Jameson Taillon | Pittsburgh Pirates | New York Yankees | Pittsburgh Pirates traded RHP Jameson Taillon to New York Yankees for RHP Roansy Contreras, SS Maikol Escotto, LF Canaan Smith and RHP Miguel Yajure. |
| Jan 23, 2021 | Signed as free agent | Daniel Vasquez | — | Kansas City Royals | Kansas City Royals signed free agent SS Daniel Vasquez to a minor league contract. |
| Jan 23, 2021 | Trade | Luke Berryhill | Cincinnati Reds | Houston Astros | Houston Astros traded LHP Cionel Perez to Cincinnati Reds for C Luke Berryhill. |
| Jan 23, 2021 | Signed as free agent | Ryan Zimmerman | — | Washington Nationals | Washington Nationals signed free agent 1B Ryan Zimmerman. |
| Jan 23, 2021 | Signed as free agent | George Springer | — | Toronto Blue Jays | Toronto Blue Jays signed free agent OF George Springer. |
| Jan 23, 2021 | Signed as free agent | Luis Martinez | — | Kansas City Royals | Kansas City Royals signed free agent LHP Luis Martinez to a minor league contract. |
| Jan 23, 2021 | Signed as free agent | Steven Cespedes | — | Kansas City Royals | Kansas City Royals signed free agent C Steven Cespedes to a minor league contract. |
| Jan 23, 2021 | Signed as free agent | Diego Guzman | — | Kansas City Royals | Kansas City Royals signed free agent SS Diego Guzman to a minor league contract. |
| Jan 23, 2021 | Signed as free agent | Angel Parra | — | Kansas City Royals | Kansas City Royals signed free agent CF Angel Parra to a minor league contract. |
| Jan 23, 2021 | Signed as free agent | Jhonny Gomez | — | Kansas City Royals | Kansas City Royals signed free agent RHP Jhonny Gomez to a minor league contract. |
| Jan 23, 2021 | Signed as free agent | Darnel Collins | — | Kansas City Royals | Kansas City Royals signed free agent OF Darnel Collins to a minor league contract. |
| Jan 23, 2021 | Signed as free agent | Oscar Rayo | — | Kansas City Royals | Kansas City Royals signed free agent LHP Oscar Rayo to a minor league contract. |
| Jan 23, 2021 | Signed as free agent | Wilson Betemit Jr. | — | Kansas City Royals | Kansas City Royals signed free agent RHP Wilson Betemit Jr. to a minor league contract. |
| Jan 23, 2021 | Signed as free agent | Francisco Ulloa | — | Kansas City Royals | Kansas City Royals signed free agent OF Francisco Ulloa to a minor league contract. |
| Jan 23, 2021 | Signed as free agent | Ismael Michel | — | Kansas City Royals | Kansas City Royals signed free agent RHP Ismael Michel to a minor league contract. |
| Jan 23, 2021 | Signed as free agent | Weskendry Espinosa | — | Kansas City Royals | Kansas City Royals signed free agent RHP Weskendry Espinoza to a minor league contract. |
| Jan 23, 2021 | Signed as free agent | Pablo Sandoval | — | Atlanta Braves | Atlanta Braves signed free agent 3B Pablo Sandoval to a minor league contract and invited him to spring training. |
| Jan 23, 2021 | Signed as free agent | Ryan Zimmerman | — | Washington Nationals | Washington Nationals signed free agent 3B Ryan Zimmerman. |
| Jan 23, 2021 | Signed as free agent | Ryan Zimmerman | — | Washington Nationals | Washington Nationals signed free agent 3B Ryan Zimmerman. |
| Jan 23, 2021 | Signed as free agent | Ryan Zimmerman | — | Washington Nationals | Washington Nationals signed free agent 3B Ryan Zimmerman. |
| Jan 23, 2021 | Signed as free agent | Ryan Zimmerman | — | Washington Nationals | Washington Nationals signed free agent 3B Ryan Zimmerman. |
| Jan 22, 2021 | Signed as free agent | J.A. Happ | — | Minnesota Twins | Minnesota Twins signed free agent LHP J.A. Happ. |
| Jan 22, 2021 | Trade | Hector Perez | Toronto Blue Jays | Cincinnati Reds | Toronto Blue Jays traded RHP Hector Perez to Cincinnati Reds for Player To Be Named Later. |
| Jan 22, 2021 | Signed as free agent | Jason Castro | — | Houston Astros | Houston Astros signed free agent C Jason Castro. |
| Jan 22, 2021 | Signed as free agent | Austin Romine | — | Chicago Cubs | Chicago Cubs signed free agent C Austin Romine. |
| Jan 22, 2021 | Signed as free agent | Jose Quintana | — | Los Angeles Angels | Los Angeles Angels signed free agent LHP Jose Quintana. |
| Jan 22, 2021 | Signed as free agent | Daniel Robertson | — | Milwaukee Brewers | Milwaukee Brewers signed free agent 3B Daniel Robertson. |
| Jan 22, 2021 | Signed as free agent | Matt Carasiti | — | Boston Red Sox | Boston Red Sox signed free agent RHP Matt Carasiti to a minor league contract and invited him to spring training. |
| Jan 22, 2021 | Signed as free agent | Starlin Aguilar | — | Seattle Mariners | Seattle Mariners signed free agent 2B Starlin Aguilar to a minor league contract. |
| Jan 22, 2021 | Signed as free agent | Daniel Robertson | — | Milwaukee Brewers | Milwaukee Brewers signed free agent 3B Daniel Robertson. |
| Jan 22, 2021 | Signed as free agent | Matt Carasiti | — | Boston Red Sox | Boston Red Sox signed free agent RHP Matt Carasiti to a minor league contract and invited him to spring training. |
| Jan 22, 2021 | Signed as free agent | Victor Labrada | — | Seattle Mariners | Seattle Mariners signed free agent Victor Labrada. |
| Jan 22, 2021 | Signed as free agent | Matt Carasiti | — | Boston Red Sox | Boston Red Sox signed free agent P Matt Carasiti. |
| Jan 22, 2021 | Signed as free agent | Jose Martinez | — | Detroit Tigers | Detroit Tigers signed free agent P Jose Martinez. |
| Jan 22, 2021 | Signed as free agent | Ricardo Yan | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent P Ricardo Yan. |
| Jan 22, 2021 | Signed as free agent | Jesus A. Rodriguez | — | Detroit Tigers | Detroit Tigers signed free agent P Jesus Rodriguez. |
| Jan 22, 2021 | Signed as free agent | Juan Cruz | — | Seattle Mariners | Seattle Mariners signed free agent OF Juan Cruz. |
| Jan 22, 2021 | Signed as free agent | Jonney Rosario | — | San Diego Padres | San Diego Padres signed free agent P Jonney Rosario. |
| Jan 22, 2021 | Signed as free agent | Ezequiel Surun | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent SS Ezequiel Surun. |
| Jan 22, 2021 | Signed as free agent | J.A. Happ | — | Minnesota Twins | Minnesota Twins signed free agent P J.A. Happ. |
| Jan 22, 2021 | Signed as free agent | Daniel Robertson | — | Milwaukee Brewers | Milwaukee Brewers signed free agent 2B Daniel Robertson. |
| Jan 22, 2021 | Signed as free agent | Jose Quintana | — | Los Angeles Angels | Los Angeles Angels signed free agent P Jose Quintana. |
| Jan 22, 2021 | Signed as free agent | Jason Castro | — | Houston Astros | Houston Astros signed free agent C Jason Castro. |
| Jan 22, 2021 | Signed as free agent | J.A. Happ | — | Minnesota Twins | Minnesota Twins signed free agent LHP J.A. Happ. |
| Jan 22, 2021 | Signed as free agent | Daniel Robertson | — | Milwaukee Brewers | Milwaukee Brewers signed free agent 2B Daniel Robertson. |
| Jan 22, 2021 | Signed as free agent | Jason Castro | — | Houston Astros | Houston Astros signed free agent C Jason Castro. |
| Jan 22, 2021 | Signed as free agent | Jose Quintana | — | Los Angeles Angels | Los Angeles Angels signed free agent LHP Jose Quintana. |
| Jan 21, 2021 | Signed as free agent | Tyler Chatwood | — | Toronto Blue Jays | Toronto Blue Jays signed free agent RHP Tyler Chatwood. |
| Jan 21, 2021 | Signed as free agent | Hans Montero | — | New York Yankees | New York Yankees signed free agent SS Hans Montero to a minor league contract. |
| Jan 20, 2021 | Signed as free agent | Wade Davis | — | Kansas City Royals | Kansas City Royals signed free agent RHP Wade Davis to a minor league contract and invited him to spring training. |
| Jan 20, 2021 | Signed as free agent | Kirby Yates | — | Toronto Blue Jays | Toronto Blue Jays signed free agent RHP Kirby Yates. |
| Jan 20, 2021 | Signed as free agent | Bryan Mitchell | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RHP Bryan Mitchell to a minor league contract. |
| Jan 20, 2021 | Signed as free agent | Luis González | — | San Francisco Giants | San Francisco Giants signed free agent LHP Luis Gonzalez to a minor league contract. |
| Jan 20, 2021 | Signed as free agent | Chris Owings | — | Colorado Rockies | Colorado Rockies signed free agent SS Chris Owings to a minor league contract and invited him to spring training. |
| Jan 20, 2021 | Signed as free agent | Wade Davis | — | Kansas City Royals | Kansas City Royals signed free agent RHP Wade Davis to a minor league contract and invited him to spring training. |
| Jan 20, 2021 | Signed as free agent | Chris Owings | — | Colorado Rockies | Colorado Rockies signed free agent SS Chris Owings to a minor league contract and invited him to spring training. |
| Jan 20, 2021 | Signed as free agent | Luis González | — | San Francisco Giants | San Francisco Giants signed free agent P Luis Gonzalez. |
| Jan 20, 2021 | Signed as free agent | Bryan Mitchell | — | Philadelphia Phillies | Philadelphia Phillies signed free agent P Bryan Mitchell. |
| Jan 20, 2021 | Signed as free agent | Osman Bravo | — | Kansas City Royals | Kansas City Royals signed free agent C Osman Bravo. |
| Jan 20, 2021 | Signed as free agent | Evan Sweeting | — | San Diego Padres | San Diego Padres signed free agent P Evan Sweeting. |
| Jan 20, 2021 | Signed as free agent | Welinton Herrera | — | Colorado Rockies | Colorado Rockies signed free agent P Welinton Herrera. |
| Jan 20, 2021 | Signed as free agent | Darien Morejon | — | Colorado Rockies | Colorado Rockies signed free agent P Darien Morejon. |
| Jan 20, 2021 | Signed as free agent | Randy Perea | — | Detroit Tigers | Detroit Tigers signed free agent OF Randy Perea. |
| Jan 20, 2021 | Signed as free agent | Hamlet Marte | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent C Hamlet Marte to a minor league contract. |
| Jan 20, 2021 | Signed as free agent | Randy Lara | — | Washington Nationals | Washington Nationals signed free agent RHP Randy Lara to a minor league contract. |
| Jan 19, 2021 | Trade | Joey Lucchesi | San Diego Padres | New York Mets | Pittsburgh Pirates Traded RHP Joe Musgrove to San Diego Padres; New York Mets Traded C Endy Rodriguez to Pittsburgh Pirates; San Diego Padres Traded LHP Joey Lucchesi to New York Mets and San Diego Padres Traded RHP David Bednar, CF Hudson Head, RHP Drake Fellows and LHP Omar Cruz to Pittsburgh Pirates. |
| Jan 19, 2021 | Signed as free agent | Hunter Wood | — | Texas Rangers | Texas Rangers signed free agent RHP Hunter Wood to a minor league contract and invited him to spring training. |
| Jan 19, 2021 | Signed as free agent | Erasmo Ramírez | — | Detroit Tigers | Detroit Tigers signed free agent RHP Erasmo Ramirez to a minor league contract and invited him to spring training. |
| Jan 19, 2021 | Signed as free agent | Jose Adames | — | Boston Red Sox | Boston Red Sox signed free agent RHP Jose Adames to a minor league contract. |
| Jan 19, 2021 | Signed as free agent | Wynton Bernard | — | Colorado Rockies | Colorado Rockies signed free agent OF Wynton Bernard to a minor league contract. |
| Jan 19, 2021 | Signed as free agent | Santiago Chávez | — | Miami Marlins | Miami Marlins signed free agent C Santiago Chavez to a minor league contract and invited him to spring training. |
| Jan 19, 2021 | Signed as free agent | Chris Chinea | — | Miami Marlins | Miami Marlins signed free agent 1B Chris Chinea to a minor league contract. |
| Jan 19, 2021 | Signed as free agent | Devin Hairston | — | Miami Marlins | Miami Marlins signed free agent SS Devin Hairston to a minor league contract. |
| Jan 19, 2021 | Signed as free agent | Luis Marté | — | Miami Marlins | Miami Marlins signed free agent SS Luis Marte to a minor league contract and invited him to spring training. |
| Jan 19, 2021 | Signed as free agent | Mike Adams | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RHP Mike Adams to a minor league contract. |
| Jan 19, 2021 | Signed as free agent | Ed Paparella | — | Seattle Mariners | Seattle Mariners signed free agent CF Eddie Paparella to a minor league contract. |
| Jan 19, 2021 | Signed as free agent | Hunter Wood | — | Texas Rangers | Texas Rangers signed free agent P Hunter Wood. |
| Jan 19, 2021 | Signed as free agent | Luis Marté | — | Miami Marlins | Miami Marlins signed free agent SS Luis Marte. |
| Jan 19, 2021 | Signed as free agent | Erasmo Ramírez | — | Detroit Tigers | Detroit Tigers signed free agent P Erasmo Ramirez. |
| Jan 19, 2021 | Signed as free agent | Wynton Bernard | — | Colorado Rockies | Colorado Rockies signed free agent CF Wynton Bernard. |
| Jan 19, 2021 | Signed as free agent | Brian Marcano | — | Cincinnati Reds | Cincinnati Reds signed free agent P Brian Marcano. |
| Jan 19, 2021 | Signed as free agent | Miguel Vargas | — | St. Louis Cardinals | St. Louis Cardinals signed free agent CF Miguel Vargas. |
| Jan 19, 2021 | Signed as free agent | Anderson Sanchez | — | Houston Astros | Houston Astros signed free agent OF Anderson Sanchez. |
| Jan 19, 2021 | Signed as free agent | Alejandro Lóaiza | — | St. Louis Cardinals | St. Louis Cardinals signed free agent C Alejandro Loaiza. |
| Jan 18, 2021 | Signed as free agent | Archie Bradley | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RHP Archie Bradley. |
| Jan 18, 2021 | Trade | C.J. Chatham | Boston Red Sox | Philadelphia Phillies | Boston Red Sox traded SS C.J. Chatham to Philadelphia Phillies for Player To Be Named Later. |
| Jan 18, 2021 | Signed as free agent | Thomas Eshelman | — | Baltimore Orioles | Baltimore Orioles signed free agent RHP Thomas Eshelman to a minor league contract and invited him to spring training. |
| Jan 18, 2021 | Signed as free agent | Edgar Arredondo | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Edgar Arredondo to a minor league contract. |
| Jan 18, 2021 | Signed as free agent | Bryan Holaday | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent C Bryan Holaday to a minor league contract and invited him to spring training. |
| Jan 18, 2021 | Signed as free agent | Zac Grotz | — | Boston Red Sox | Boston Red Sox signed free agent RHP Zac Grotz to a minor league contract and invited him to spring training. |
| Jan 18, 2021 | Signed as free agent | Luke Shilling | — | Chicago White Sox | Chicago White Sox signed free agent RHP Luke Shilling to a minor league contract. |
| Jan 18, 2021 | Signed as free agent | Matt Tomshaw | — | Chicago White Sox | Chicago White Sox signed free agent LHP Matt Tomshaw to a minor league contract and invited him to spring training. |
| Jan 18, 2021 | Signed as free agent | Nick Williams | — | Chicago White Sox | Chicago White Sox signed free agent LF Nick Williams to a minor league contract and invited him to spring training. |
| Jan 18, 2021 | Signed as free agent | Daniel Vazquez | — | Kansas City Royals | Kansas City Royals signed free agent SS Daniel Vazquez to a minor league contract. |
| Jan 18, 2021 | Signed as free agent | Stephen Ridings | — | New York Yankees | New York Yankees signed free agent RHP Stephen Ridings to a minor league contract. |
| Jan 18, 2021 | Signed as free agent | Kyle Mottice | — | San Francisco Giants | San Francisco Giants signed free agent 1B Kyle Mottice to a minor league contract. |
| Jan 18, 2021 | Signed as free agent | David Paulino | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RHP David Paulino to a minor league contract. |
| Jan 18, 2021 | Signed as free agent | Welington Castillo | — | Washington Nationals | Washington Nationals signed free agent C Welington Castillo to a minor league contract and invited him to spring training. |
| Jan 18, 2021 | Signed as free agent | Bryan Dobzanski | — | Washington Nationals | Washington Nationals signed free agent RHP Bryan Dobzanski to a minor league contract. |
| Jan 18, 2021 | Signed as free agent | Osvaldo Duarte | — | Washington Nationals | Washington Nationals signed free agent 2B Osvaldo Duarte to a minor league contract. |
| Jan 18, 2021 | Signed as free agent | Brayan Mendoza | — | Texas Rangers | Texas Rangers signed free agent LHP Brayan Mendoza to a minor league contract. |
| Jan 18, 2021 | Signed as free agent | Ryan Buchter | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent LHP Ryan Buchter to a minor league contract and invited him to spring training. |
| Jan 18, 2021 | Signed as free agent | Pedro Florimón | — | San Diego Padres | San Diego Padres signed free agent SS Pedro Florimon to a minor league contract and invited him to spring training. |
| Jan 18, 2021 | Signed as free agent | Rocky Gale | — | Cincinnati Reds | Cincinnati Reds signed free agent C Rocky Gale to a minor league contract and invited him to spring training. |
| Jan 18, 2021 | Signed as free agent | Pedro Florimón | — | San Diego Padres | San Diego Padres signed free agent SS Pedro Florimon to a minor league contract and invited him to spring training. |
| Jan 18, 2021 | Signed as free agent | Nick Williams | — | Chicago White Sox | Chicago White Sox signed free agent LF Nick Williams to a minor league contract and invited him to spring training. |
| Jan 18, 2021 | Signed as free agent | Matt Tomshaw | — | Chicago White Sox | Chicago White Sox signed free agent LHP Matt Tomshaw to a minor league contract and invited him to spring training. |
| Jan 18, 2021 | Signed as free agent | Zac Grotz | — | Boston Red Sox | Boston Red Sox signed free agent RHP Zac Grotz to a minor league contract and invited him to spring training. |
| Jan 18, 2021 | Signed as free agent | Thomas Eshelman | — | Baltimore Orioles | Baltimore Orioles signed free agent RHP Thomas Eshelman to a minor league contract and invited him to spring training. |
| Jan 18, 2021 | Signed as free agent | Bryan Holaday | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent C Bryan Holaday to a minor league contract and invited him to spring training. |
| Jan 18, 2021 | Signed as free agent | Ryan Buchter | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent LHP Ryan Buchter to a minor league contract and invited him to spring training. |
| Jan 18, 2021 | Signed as free agent | Welington Castillo | — | Washington Nationals | Washington Nationals signed free agent C Welington Castillo. |
| Jan 18, 2021 | Signed as free agent | Pedro Florimón | — | San Diego Padres | San Diego Padres signed free agent SS Pedro Florimon. |
| Jan 18, 2021 | Signed as free agent | Rocky Gale | — | Cincinnati Reds | Cincinnati Reds signed free agent C Rocky Gale. |
| Jan 18, 2021 | Signed as free agent | Nick Williams | — | Chicago White Sox | Chicago White Sox signed free agent RF Nick Williams. |
| Jan 18, 2021 | Signed as free agent | Matt Tomshaw | — | Chicago White Sox | Chicago White Sox signed free agent P Matt Tomshaw. |
| Jan 18, 2021 | Signed as free agent | Zac Grotz | — | Boston Red Sox | Boston Red Sox signed free agent P Zac Grotz. |
| Jan 18, 2021 | Signed as free agent | Thomas Eshelman | — | Baltimore Orioles | Baltimore Orioles signed free agent P Thomas Eshelman. |
| Jan 18, 2021 | Signed as free agent | Ryan Buchter | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent P Ryan Buchter. |
| Jan 18, 2021 | Signed as free agent | Javier Chacon | — | San Diego Padres | San Diego Padres signed free agent P Javier Chacon. |
| Jan 17, 2021 | Signed as free agent | Juan Martinez | — | Cincinnati Reds | Cincinnati Reds signed free agent P Juan Martinez. |
| Jan 16, 2021 | Signed as free agent | Yariel Gonzalez | — | Detroit Tigers | Detroit Tigers signed free agent 1B Yariel Gonzalez to a minor league contract. |
| Jan 16, 2021 | Signed as free agent | Aderlin Rodríguez | — | Detroit Tigers | Detroit Tigers signed free agent 1B Aderlin Rodriguez to a minor league contract and invited him to spring training. |
| Jan 16, 2021 | Signed as free agent | Andrew Moore | — | Detroit Tigers | Detroit Tigers signed free agent RHP Andrew Moore to a minor league contract. |
| Jan 16, 2021 | Signed as free agent | Robbie Ross Jr. | — | Detroit Tigers | Detroit Tigers signed free agent LHP Robbie Ross Jr. to a minor league contract. |
| Jan 16, 2021 | Signed as free agent | Alberto Mota | — | Texas Rangers | Texas Rangers signed free agent RHP Alberto Mota to a minor league contract. |
| Jan 16, 2021 | Signed as free agent | Francisco Laya | — | Texas Rangers | Texas Rangers signed free agent OF Francisco Laya to a minor league contract. |
| Jan 16, 2021 | Signed as free agent | Jack López | — | Boston Red Sox | Boston Red Sox signed free agent 2B Jack Lopez to a minor league contract. |
| Jan 16, 2021 | Signed as free agent | Aderlin Rodríguez | — | Detroit Tigers | Detroit Tigers signed free agent 3B Aderlin Rodriguez. |
| Jan 16, 2021 | Signed as free agent | Robbie Ross Jr. | — | Detroit Tigers | Detroit Tigers signed free agent P Robbie Ross Jr.. |
| Jan 15, 2021 | Signed as free agent | Liam Hendriks | — | Chicago White Sox | Chicago White Sox signed free agent RHP Liam Hendriks. |
| Jan 15, 2021 | Signed as free agent | Yiddi Cappe | — | Miami Marlins | Miami Marlins signed free agent SS Yiddi Cappe to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Oscar Colina | — | Miami Marlins | Miami Marlins signed free agent OF Oscar Colina to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Kevin Guerrero | — | Miami Marlins | Miami Marlins signed free agent OF Kevin Guerrero to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Jesus Leon | — | Miami Marlins | Miami Marlins signed free agent LHP Jesus Leon to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Gerardo Hernandez | — | Miami Marlins | Miami Marlins signed free agent RHP Gerardo Hernandez to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Luis Baldiris | — | Miami Marlins | Miami Marlins signed free agent LHP Luis Baldiris to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Edward Duran | — | Miami Marlins | Miami Marlins signed free agent C Edward Duran to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Jesus Hernandez | — | Miami Marlins | Miami Marlins signed free agent SS Jesus Hernandez to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Reiner Chourio | — | Miami Marlins | Miami Marlins signed free agent SS Reiner Chourio to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Ronald Hernandez | — | Miami Marlins | Miami Marlins signed free agent C Ronald Hernandez to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Jhoniel Serrano | — | Miami Marlins | Miami Marlins signed free agent RHP Jhoniel Serrano to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Samuel Basallo | — | Baltimore Orioles | Baltimore Orioles signed free agent C Samuel Basallo to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Yasmil Bucce | — | Baltimore Orioles | Baltimore Orioles signed free agent C Yasmil Bucce to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Aneudis Mordán | — | Baltimore Orioles | Baltimore Orioles signed free agent C Aneudis Mordan to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Maikol Hernández | — | Baltimore Orioles | Baltimore Orioles signed free agent SS Maikol Hernandez to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Eruviel Castillo | — | Baltimore Orioles | Baltimore Orioles signed free agent SS Eruviel Castillo to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Junior Lara | — | Baltimore Orioles | Baltimore Orioles signed free agent OF Junior Lara to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Elvis Polanco | — | Baltimore Orioles | Baltimore Orioles signed free agent LHP Elvis Polanco to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Teudis Cortorreal | — | Baltimore Orioles | Baltimore Orioles signed free agent OF Teudis Cortorreal to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Héctor Jiménez | — | Baltimore Orioles | Baltimore Orioles signed free agent OF Hector Jimenez to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Angel Tejada | — | Baltimore Orioles | Baltimore Orioles signed free agent SS Angel Tejada to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Deivy Cruz | — | Baltimore Orioles | Baltimore Orioles signed free agent LHP Deivy Cruz to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Wilmer Feliciano | — | Baltimore Orioles | Baltimore Orioles signed free agent OF Wilmer Feliciano to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Anderson De Los Santos | — | Baltimore Orioles | Baltimore Orioles signed free agent SS Anderson De Los Santos to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Grabiel Salazar | — | Baltimore Orioles | Baltimore Orioles signed free agent OF Grabiel Salazar to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Victor Celedonio | — | Baltimore Orioles | Baltimore Orioles signed free agent SS Victor Celedonio to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Diego Velasquez | — | San Francisco Giants | San Francisco Giants signed free agent SS Diego Velasquez to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Jediael Maduro | — | San Francisco Giants | San Francisco Giants signed free agent OF Jediael Maduro to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Eliam Sandoval | — | San Francisco Giants | San Francisco Giants signed free agent OF Eliam Sandoval to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Carlos Rodríguez | — | Baltimore Orioles | Baltimore Orioles signed free agent C Carlos Rodriguez to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Angel Pena | — | Baltimore Orioles | Baltimore Orioles signed free agent OF Angel Pena to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Angel Polo | — | San Francisco Giants | San Francisco Giants signed free agent C Angel Polo to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Saul Bautista | — | San Francisco Giants | San Francisco Giants signed free agent OF Saul Bautista to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Jose T. Perez | — | San Francisco Giants | San Francisco Giants signed free agent RHP Jose Perez to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Pavel Duarte | — | San Francisco Giants | San Francisco Giants signed free agent LHP Pavel Duarte to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Brandy Rosario | — | San Francisco Giants | San Francisco Giants signed free agent SS Brandy Rosario to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Gerelmi Maldonado | — | San Francisco Giants | San Francisco Giants signed free agent RHP Gerelmi Maldonado to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Samir Chires | — | San Francisco Giants | San Francisco Giants signed free agent RHP Samir Chires to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Diego Villegas | — | San Francisco Giants | San Francisco Giants signed free agent OF Diego Villegas to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Ramon Peralta | — | San Francisco Giants | San Francisco Giants signed free agent SS Ramon Peralta to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Angel Sanchez | — | San Francisco Giants | San Francisco Giants signed free agent RHP Angel Sanchez to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Anderson Azor | — | San Francisco Giants | San Francisco Giants signed free agent RHP Anderson Azor to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Jan Caraballo | — | San Francisco Giants | San Francisco Giants signed free agent RHP Jan Caraballo to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Juanel Urena | — | San Francisco Giants | San Francisco Giants signed free agent OF Juanel Urena to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Carlos Rosario | — | San Francisco Giants | San Francisco Giants signed free agent OF Carlos Rosario to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Ricardo Estrada | — | San Francisco Giants | San Francisco Giants signed free agent LHP Ricardo Estrada to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Mauricio Pierre | — | San Francisco Giants | San Francisco Giants signed free agent OF Mauricio Pierre to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Randy Arrieta | — | San Francisco Giants | San Francisco Giants signed free agent OF Randy Arrieta to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Jhosward Camacho | — | San Francisco Giants | San Francisco Giants signed free agent SS Jhosward Camacho to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Brian Guzman | — | San Francisco Giants | San Francisco Giants signed free agent OF Brian Guzman to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Samuel Rodriguez | — | San Francisco Giants | San Francisco Giants signed free agent SS Samuel Rodriguez to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Javier Castillo | — | San Francisco Giants | San Francisco Giants signed free agent C Javier Castillo to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Carlos Rangel | — | San Francisco Giants | San Francisco Giants signed free agent RHP Carlos Rangel to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Brayan Ferrer | — | San Francisco Giants | San Francisco Giants signed free agent C Brayan Ferrer to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Daniel Espinoza | — | San Francisco Giants | San Francisco Giants signed free agent LHP Daniel Espinoza to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Jose Astudillo | — | San Francisco Giants | San Francisco Giants signed free agent SS Jose Astudillo to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Gustavo Cardozo | — | San Francisco Giants | San Francisco Giants signed free agent SS Gustavo Cardozo to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Fabio Villadiego | — | San Francisco Giants | San Francisco Giants signed free agent OF Fabio Villadiego to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Rayner Castillo | — | Detroit Tigers | Detroit Tigers signed free agent RHP Rayner Castillo to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Diego Gonzalez | — | San Francisco Giants | San Francisco Giants signed free agent C Diego Gonzalez to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Derwin Laya | — | San Francisco Giants | San Francisco Giants signed free agent 3B Derwin Laya to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Eduardo Montero | — | San Francisco Giants | San Francisco Giants signed free agent C Eduardo Montero to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Jose Rojas | — | San Francisco Giants | San Francisco Giants signed free agent RHP Jose Rojas to a minor league contract. |
| Jan 15, 2021 | Released | Walker Lockett | — | Toronto Blue Jays | Toronto Blue Jays released RHP Walker Lockett. |
| Jan 15, 2021 | Signed as free agent | Cristian Santana | — | Detroit Tigers | Detroit Tigers signed free agent SS Cristian Santana to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Joel Baez | — | Detroit Tigers | Detroit Tigers signed free agent RHP Joel Baez to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Jefrem Leon | — | Washington Nationals | Washington Nationals signed free agent RHP Jefrem Leon to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Gustavo Rivas | — | Washington Nationals | Washington Nationals signed free agent RHP Gustavo Rivas to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Genderson Zapata | — | Washington Nationals | Washington Nationals signed free agent RHP Genderson Zapata to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Carlos Pelegrin | — | Detroit Tigers | Detroit Tigers signed free agent OF Carlos Pelegrin to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Doimil Perez | — | Washington Nationals | Washington Nationals signed free agent RHP Doimil Perez to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Armando Cruz | — | Washington Nationals | Washington Nationals signed free agent SS Armando Cruz to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Enmanuel Ramirez | — | Washington Nationals | Washington Nationals signed free agent OF Enmanuel Ramirez to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Jean Estrada | — | Washington Nationals | Washington Nationals signed free agent OF Jean Estrada to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Gabriel Agostini | — | Washington Nationals | Washington Nationals signed free agent LHP Gabriel Agostini to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Winder Diaz | — | Washington Nationals | Washington Nationals signed free agent 3B Winder Diaz to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Cristian Batista | — | Washington Nationals | Washington Nationals signed free agent OF Cristian Batista to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Yeferson Tineo | — | Texas Rangers | Texas Rangers signed free agent SS Yeferson Tineo to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Danyer Cueva | — | Texas Rangers | Texas Rangers signed free agent SS Danyer Cueva to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Yeison Morrobel | — | Texas Rangers | Texas Rangers signed free agent OF Yeison Morrobel to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Dayker Baldallo | — | Athletics | Oakland Athletics signed free agent SS Dayker Baldallo to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Gimy Rojas | — | Athletics | Oakland Athletics signed free agent RHP Jimmy Rojas to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Moises Hernandez | — | Athletics | Oakland Athletics signed free agent RHP Moises Hernandez to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Angel Arevalo | — | Athletics | Oakland Athletics signed free agent OF Angel Arevalo to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Pedro Pineda | — | Athletics | Oakland Athletics signed free agent OF Pedro Pineda to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Javier Pariguan | — | Athletics | Oakland Athletics signed free agent C Javier Pariguan to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Beyker Martinez | — | Athletics | Oakland Athletics signed free agent OF Beyker Martinez to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Ray Garrett | — | Athletics | Oakland Athletics signed free agent SS Ray Garrett to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Anderson Machado | — | Athletics | Oakland Athletics signed free agent SS Anderson Machado to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | German Ortiz | — | Athletics | Oakland Athletics signed free agent SS German Ortiz to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Jesus Perdigon | — | Athletics | Oakland Athletics signed free agent RHP Jesus Perdigon to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Shalin Polanco | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent OF Shalin Polanco to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | John Zorrilla | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent SS John Zorrilla to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Sulivan Ribeiro | — | Athletics | Oakland Athletics signed free agent LHP Sulivan Ribeiro to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Yoelqui Céspedes | — | Chicago White Sox | Chicago White Sox signed free agent OF Yoelqui Cespedes to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Ruben Vizcaya | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent OF Ruben Vizcaya to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Jose Garces | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent RHP Jose Garces to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Eddy Rodriguez | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent OF Eddy Rodriguez to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Wilmer Difo | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent 2B Wilmer Difo to a minor league contract and invited him to spring training. |
| Jan 15, 2021 | Signed as free agent | Darlin Diaz | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent RHP Darlin Diaz to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Antwone Kelly | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent RHP Antwone Kelly to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Andres Sierra | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent RHP Andres Sierra to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Luigi Hernandez | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent RHP Luigi Hernandez to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Rodolfo De La Cruz | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent OF Rodolfo De La Cruz to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Esmerlyn Valdez | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent OF Esmerlyn Valdez to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Rubel Lebron | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent SS Rubel Lebron to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Wesley Zapata | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent SS Wesley Zapata to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Miguel Sosa | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent C Miguel Sosa to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Samil De La Rosa | — | St. Louis Cardinals | St. Louis Cardinals signed free agent 3B Samil De La Rosa to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Romtres Cabrera | — | St. Louis Cardinals | St. Louis Cardinals signed free agent OF Romtres Cabrera to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Marcelo Perez | — | St. Louis Cardinals | St. Louis Cardinals signed free agent SS Marcelo Perez to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Pedro León | — | Houston Astros | Houston Astros signed free agent OF Pedro Leon to a minor league contract and invited him to spring training. |
| Jan 15, 2021 | Signed as free agent | Jesus Clode | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent RHP Jesus Clode to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Adari Grant | — | St. Louis Cardinals | St. Louis Cardinals signed free agent SS Adari Grant to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Elias Reynoso | — | St. Louis Cardinals | St. Louis Cardinals signed free agent SS Elias Reynoso to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Samuel Fabian | — | St. Louis Cardinals | St. Louis Cardinals signed free agent RHP Samuel Fabian to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Robelyn Lopez | — | St. Louis Cardinals | St. Louis Cardinals signed free agent OF Robelyn Lopez to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Leo Bernal | — | St. Louis Cardinals | St. Louis Cardinals signed free agent C Leonardo Bernal to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Carlos De La Cruz | — | St. Louis Cardinals | St. Louis Cardinals signed free agent RHP Carlos De La Cruz to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Yancel Guerrero | — | St. Louis Cardinals | St. Louis Cardinals signed free agent SS Yancel Guerrero to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | José Suárez | — | St. Louis Cardinals | St. Louis Cardinals signed free agent OF Jose Suarez to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Carlos Carmona | — | St. Louis Cardinals | St. Louis Cardinals signed free agent OF Carlos Carmona to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Anyelo Encarnación | — | St. Louis Cardinals | St. Louis Cardinals signed free agent SS Anyelo Encarnacion to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Christian Avendano | — | St. Louis Cardinals | St. Louis Cardinals signed free agent OF Christian Avendano to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Esteban Contreras | — | St. Louis Cardinals | St. Louis Cardinals signed free agent RHP Esteban Contreras to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Elian Riera | — | Detroit Tigers | Detroit Tigers signed free agent OF Elian Riera to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Abel Bastidas | — | Detroit Tigers | Detroit Tigers signed free agent SS Abel Bastidas to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Jensy De Leon | — | Detroit Tigers | Detroit Tigers signed free agent SS Jensy De Leon to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Carlos Arcila | — | Houston Astros | Houston Astros signed free agent C Carlos Arcila to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Brayan Nolasco | — | Houston Astros | Houston Astros signed free agent OF Brayan Nolasco to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Elvin Villega | — | Houston Astros | Houston Astros signed free agent RHP Elvin Villega to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Darwin Rosario | — | Houston Astros | Houston Astros signed free agent RHP Darwin Rosario to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Freilyn De Pena | — | Houston Astros | Houston Astros signed free agent RHP Freilyn De Pena to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Miguel Ullola | — | Houston Astros | Houston Astros signed free agent RHP Miguel Ullola to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Angel Genao | — | Cleveland Guardians | Cleveland Indians signed free agent SS Angel Genao to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Adonis Cepeda | — | Cleveland Guardians | Cleveland Indians signed free agent OF Adonis Cepeda to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Luis Perez | — | Cleveland Guardians | Cleveland Indians signed free agent SS Luis Perez to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Juan Soto | — | Houston Astros | Houston Astros signed free agent RHP Juan Soto to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Richel Del Rosario | — | Houston Astros | Houston Astros signed free agent OF Richel Del Rosario to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Yamal Encarnacion | — | Houston Astros | Houston Astros signed free agent IF Yamal Encarnacion to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Fran Alduey | — | Cleveland Guardians | Cleveland Indians signed free agent SS Fran Alduey to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Richard Polanco | — | Cleveland Guardians | Cleveland Indians signed free agent SS Richard Polanco to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Jesus Montilla | — | Cleveland Guardians | Cleveland Indians signed free agent SS Jesus Montilla to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Lerwin Andrade | — | Cleveland Guardians | Cleveland Indians signed free agent SS Lerwin Andrade to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Carlos Gutierrez | — | Cleveland Guardians | Cleveland Indians signed free agent OF Carlos Gutierrez to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Yefri Rivera | — | Cleveland Guardians | Cleveland Indians signed free agent SS Yefri Rivera to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Manuel Mejias | — | Cleveland Guardians | Cleveland Indians signed free agent RHP Manuel Mejias to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Christopher Espinola | — | Cleveland Guardians | Cleveland Indians signed free agent OF Christopher Espinola to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Pedro Báez | — | Houston Astros | Houston Astros signed free agent RHP Pedro Baez. |
| Jan 15, 2021 | Signed as free agent | Reyden Hidalgo | — | Cleveland Guardians | Cleveland Indians signed free agent SS Reyden Hidalgo to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Robert Lopez | — | Cleveland Guardians | Cleveland Indians signed free agent C Robert Lopez to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Austin Aldeano | — | Cleveland Guardians | Cleveland Indians signed free agent RHP Austin Aldeano to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Ronald Pena | — | Cleveland Guardians | Cleveland Indians signed free agent OF Ronald Pena to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Jesus Galiz | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent C Jesus Galiz to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Missael Soto | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Missael Soto to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Dailoui Abad | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Dailoui Abad to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Rayne Doncon | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent SS Rayne Doncon to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Wilman Diaz | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent SS Wilman Diaz to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Jorge Carpintero | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent LHP Jorge Carpintero to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Maximo Martinez | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Maximo Martinez to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Kelvin Ramirez | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Kelvin Ramirez to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Pedro Santillan | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Pedro Santillan to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Isaac Barreto | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent OF Isaac Barreto to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Luis Guerra | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent SS Luis Guerra to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Carlos Avila | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent C Carlos Avila to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Sebastian Jimenez | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent LHP Sebastian Jimenez to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Roger Lasso | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent OF Roger Lasso to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Elio Campos | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent SS Elio Campos to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Brian Diaz | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Brian Diaz to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Michael Vilchez | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Michael Vilchez to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Jhonny Jimenez | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Jhonny Jimenez to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Christian Romero | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Christian Romero to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Miguel Bastardo | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Miguel Bastardo to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Thayron Liranzo | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent C Thayron Liranzo to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Juan Alonso | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent OF Juan Alonso to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Carlos Colmenarez | — | Tampa Bay Rays | Tampa Bay Rays signed free agent SS Carlos Colmenarez to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Jhonny Piron | — | Tampa Bay Rays | Tampa Bay Rays signed free agent OF Jhonny Piron to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Jose Perez | — | Tampa Bay Rays | Tampa Bay Rays signed free agent SS Jose Perez to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Sebastian Javier | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP Sebastian Javier to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Nathanael Rodriguez | — | Tampa Bay Rays | Tampa Bay Rays signed free agent SS Nathanael Rodriguez to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Humberto Jimenez | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP Humberto Jimenez to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Kikito Severino | — | Tampa Bay Rays | Tampa Bay Rays signed free agent LHP Kikito Severino to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Luis Ariza | — | Tampa Bay Rays | Tampa Bay Rays signed free agent SS Luis Ariza to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Jesus Quevedo | — | Tampa Bay Rays | Tampa Bay Rays signed free agent SS Jesus Quevedo to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Kurt Suzuki | — | Los Angeles Angels | Los Angeles Angels signed free agent C Kurt Suzuki. |
| Jan 15, 2021 | Signed as free agent | Manuel Beltre | — | Toronto Blue Jays | Toronto Blue Jays signed free agent SS Manuel Beltre to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Luis Garcia | — | Toronto Blue Jays | Toronto Blue Jays signed free agent SS Luis Garcia to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Gabriel Arias | — | Tampa Bay Rays | Tampa Bay Rays signed free agent RHP Gabriel Arias to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Jonathan Peguero | — | Toronto Blue Jays | Toronto Blue Jays signed free agent C Jonathan Peguero to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Robin De Jesus | — | Toronto Blue Jays | Toronto Blue Jays signed free agent RHP Robin De Jesus to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Luis Bautista | — | Toronto Blue Jays | Toronto Blue Jays signed free agent IF Luis Bautista to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Keni Salgado | — | Detroit Tigers | Detroit Tigers signed free agent RHP Keni Salgado to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Yeuni Munoz | — | Toronto Blue Jays | Toronto Blue Jays signed free agent OF Yeuni Munoz to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Yhoangel Aponte | — | Toronto Blue Jays | Toronto Blue Jays signed free agent OF Yhoangel Aponte to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Angel Santana | — | Toronto Blue Jays | Toronto Blue Jays signed free agent RHP Angel Santana to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Manuel Contreras | — | Toronto Blue Jays | Toronto Blue Jays signed free agent IF Manuel Contreras to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Livan Chaviano | — | Toronto Blue Jays | Toronto Blue Jays signed free agent RHP Livan Chaviano to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Adriel Sotolongo | — | Toronto Blue Jays | Toronto Blue Jays signed free agent 3B Adriel Sotolongo to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Justin Rodriguez | — | Detroit Tigers | Detroit Tigers signed free agent SS Justin Rodriguez to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Yimmy Diaz | — | Detroit Tigers | Detroit Tigers signed free agent SS Yimmy Diaz to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Reynardo Cruz | — | Cincinnati Reds | Cincinnati Reds signed free agent RHP Raynardo Cruz to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Cristian Galindo | — | Cincinnati Reds | Cincinnati Reds signed free agent LHP Cristian Galindo to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Ambioris Tavarez | — | Atlanta Braves | Atlanta Braves signed free agent SS Ambioris Tavarez to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Malvin Valdez | — | Cincinnati Reds | Cincinnati Reds signed free agent OF Malvin Valdez to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Ariel Almonte | — | Cincinnati Reds | Cincinnati Reds signed free agent OF Ariel Almonte to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Luis Reyes | — | Cincinnati Reds | Cincinnati Reds signed free agent IF Luis Reyes to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Alejandro Rodriguez | — | Cincinnati Reds | Cincinnati Reds signed free agent RHP Alejandro Rodriguez to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Eddy Isturiz | — | Cincinnati Reds | Cincinnati Reds signed free agent C Eddy Isturiz to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Diego Omana | — | Cincinnati Reds | Cincinnati Reds signed free agent C Diego Omana to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Luis Castro | — | Cincinnati Reds | Cincinnati Reds signed free agent RHP Luis Castro to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Carlos Jorge | — | Cincinnati Reds | Cincinnati Reds signed free agent SS Carlos Jorge to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Eiver Betancourt | — | Los Angeles Angels | Los Angeles Angels signed free agent C Eiver Betancourt to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Kleiver Lopez | — | Los Angeles Angels | Los Angeles Angels signed free agent SS Kleiver Lopez to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Jose Serrano | — | Cincinnati Reds | Cincinnati Reds signed free agent SS Jose Serrano to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Brayan Rijo | — | Cincinnati Reds | Cincinnati Reds signed free agent OF Brayan Rijo to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Leo Balcazar | — | Cincinnati Reds | Cincinnati Reds signed free agent SS Leonardo Balcazar to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Denzer Guzman | — | Los Angeles Angels | Los Angeles Angels signed free agent SS Denzer Guzman to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Darlin Francia | — | Los Angeles Angels | Los Angeles Angels signed free agent RHP Darlin Francia to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Luis Viloria | — | Los Angeles Angels | Los Angeles Angels signed free agent LHP Luis Viloria to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Erick Reyes | — | Milwaukee Brewers | Milwaukee Brewers signed free agent SS Erick Reyes to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Pedro Riera | — | Milwaukee Brewers | Milwaukee Brewers signed free agent SS Pedro Riera to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Manuel Vargas | — | Milwaukee Brewers | Milwaukee Brewers signed free agent OF Manuel Vargas to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Fernando Guanare | — | Los Angeles Angels | Los Angeles Angels signed free agent RHP Fernando Guanare to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Daniel Guilarte | — | Milwaukee Brewers | Milwaukee Brewers signed free agent SS Daniel Guilarte to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Richard Rojas | — | Milwaukee Brewers | Milwaukee Brewers signed free agent SS Richard Rojas to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Jackson Chourio | — | Milwaukee Brewers | Milwaukee Brewers signed free agent CF Jackson Chourio to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Hendry Mendez | — | Milwaukee Brewers | Milwaukee Brewers signed free agent OF Hendry Mendez to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Felipe Valderrama | — | Milwaukee Brewers | Milwaukee Brewers signed free agent C Felipe Valderrama to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Alejandro Hernandez | — | San Diego Padres | San Diego Padres signed free agent IF Alejandro Hernandez to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Yariel Moreno | — | San Diego Padres | San Diego Padres signed free agent RHP Yariel Moreno to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Gregory Barrios | — | Milwaukee Brewers | Milwaukee Brewers signed free agent SS Gregory Barrios to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Luis Castillo | — | Milwaukee Brewers | Milwaukee Brewers signed free agent OF Luis Castillo to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Jared Albir | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Jared Albir to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Dikember Sanchez | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Dikember Sanchez to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Jadher Areinamo | — | Milwaukee Brewers | Milwaukee Brewers signed free agent SS Jadher Areinamo to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Alex Vallecillo | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Alexander Vallecillo to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Eddy Beltre | — | San Diego Padres | San Diego Padres signed free agent OF Eddy Beltre to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Bradgley Rodriguez | — | San Diego Padres | San Diego Padres signed free agent RHP Bradgley Rodriguez to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Daniel Montesino | — | San Diego Padres | San Diego Padres signed free agent OF Daniel Montesino to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Samuel Zavala | — | San Diego Padres | San Diego Padres signed free agent OF Samuel Zavala to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Victor Acosta | — | San Diego Padres | San Diego Padres signed free agent SS Victor Acosta to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Heber Villalobos | — | San Diego Padres | San Diego Padres signed free agent C Heber Villalobos to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Gabriel Liendo | — | Atlanta Braves | Atlanta Braves signed free agent SS Gabriel Liendo to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Josue Castillo | — | Boston Red Sox | Boston Red Sox signed free agent SS Josue Castillo to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Miguel Bleis | — | Boston Red Sox | Boston Red Sox signed free agent OF Miguel Bleis to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Enderso Lira | — | Boston Red Sox | Boston Red Sox signed free agent C Enderso Lira to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Jedixson Paez | — | Boston Red Sox | Boston Red Sox signed free agent RHP Jedixson Paez to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Karim Ayubi | — | Boston Red Sox | Boston Red Sox signed free agent OF Karim Ayubi to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Luis Ravelo | — | Boston Red Sox | Boston Red Sox signed free agent SS Luis Ravelo to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Yizreel Burnet | — | Boston Red Sox | Boston Red Sox signed free agent RHP Yizreel Burnet to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Elvys Castro | — | Boston Red Sox | Boston Red Sox signed free agent OF Elvys Castro to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Armando Sierra | — | Boston Red Sox | Boston Red Sox signed free agent OF Armando Sierra to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Helison Mota | — | Boston Red Sox | Boston Red Sox signed free agent IF Helison Mota to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Ahbram Liendo | — | Boston Red Sox | Boston Red Sox signed free agent IF Ahbram Liendo to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Yevganni Reinita | — | Boston Red Sox | Boston Red Sox signed free agent IF Yevganni Reinita to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Jean Carlos Reyes | — | Boston Red Sox | Boston Red Sox signed free agent RHP Jean Carlos Reyes to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Alvaro Mejias | — | Boston Red Sox | Boston Red Sox signed free agent RHP Alvaro Mejias to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Kevin Briceno | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Kevin Briceno to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Yeison Perez | — | Milwaukee Brewers | Milwaukee Brewers signed free agent OF Yeison Perez to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Edgardo Ordonez | — | Milwaukee Brewers | Milwaukee Brewers signed free agent C Edgardo Ordonez to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Samuel Escudero | — | Milwaukee Brewers | Milwaukee Brewers signed free agent C Samuel Escudero to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Elian Lozano | — | Texas Rangers | Texas Rangers signed free agent C Elian Lozano to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Edgar Basabe | — | Texas Rangers | Texas Rangers signed free agent OF Edgar Basabe to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Kliber Geraldo | — | Texas Rangers | Texas Rangers signed free agent SS Kliber Geraldo to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Gleider Figuereo | — | Texas Rangers | Texas Rangers signed free agent SS Gleider Figuereo to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Frandy Almonte | — | Texas Rangers | Texas Rangers signed free agent SS Frandy Almonte to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Eward Rodriguez | — | Texas Rangers | Texas Rangers signed free agent RHP Eward Rodriguez to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Andy Beato | — | Texas Rangers | Texas Rangers signed free agent C Andy Beato to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Gedionne Marlin | — | Texas Rangers | Texas Rangers signed free agent SS Gedionne Marlin to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Keiderson Pavon | — | Texas Rangers | Texas Rangers signed free agent SS Keiderson Pavon to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Julio Pinto | — | Texas Rangers | Texas Rangers signed free agent SS Julio Pinto to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Isaac Castellanos | — | Texas Rangers | Texas Rangers signed free agent LHP Isaac Castellanos to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Hector Pinero | — | Texas Rangers | Texas Rangers signed free agent SS Hector Pinero to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Ismael Agreda | — | Texas Rangers | Texas Rangers signed free agent RHP Ismael Agreda to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Jose V. Felix | — | Texas Rangers | Texas Rangers signed free agent RHP Jose V. Felix to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Ivan Oviedo | — | Texas Rangers | Texas Rangers signed free agent RHP Ivan Oviedo to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Leandro Lopez | — | Texas Rangers | Texas Rangers signed free agent RHP Leandro Calderon to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Wilmer Castro | — | Texas Rangers | Texas Rangers signed free agent OF Wilmer Castro to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Duncan Garcia | — | Milwaukee Brewers | Milwaukee Brewers signed free agent OF Duncan Garcia to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Leonardo Rivera | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Leonardo Rivera to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Waldin Rodriguez | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Waldin Rodriguez to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Egduard Winterdaal | — | Milwaukee Brewers | Milwaukee Brewers signed free agent OF Egduard Winterdaal to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Ney Serrano | — | Milwaukee Brewers | Milwaukee Brewers signed free agent SS Ney Serrano to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Daniel Jean | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent LHP Daniel Jean to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Alexander Benua | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent SS Alexander Benua to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Henry Garrido | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Henry Garrido to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Patricio Aquino | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Patricio Aquino to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Jonatan Guzman | — | Milwaukee Brewers | Milwaukee Brewers signed free agent SS Jonatan Guzman to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Lisandro Almonte | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Lisandro Almonte to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Kevin Santos | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent OF Kevin Santos to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Jakey Josepha | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent SS Jakey Josepha to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Lorenzo Encarnacion | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Lorenzo Encarnacion to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Jesus Jimenez | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Jesus Jimenez to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Anderdson Rojas | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent 2B Anderdson Rojas to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Victor Brea | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent LHP Victor Brea to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | David Leon | — | Cleveland Guardians | Cleveland Indians signed free agent C David Leon to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Aaron Martinez | — | New York Mets | New York Mets signed free agent RHP Aaron Martinez to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Danny De Andrade | — | Minnesota Twins | Minnesota Twins signed free agent SS Danny De Andrade to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Luis Rodriguez | — | Minnesota Twins | Minnesota Twins signed free agent IF Luis Rodriguez to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Javier Moreno | — | Minnesota Twins | Minnesota Twins signed free agent C Javier Moreno to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Jefferson De La Cruz | — | Minnesota Twins | Minnesota Twins signed free agent OF Jefferson De La Cruz to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Denyerbe Gervis | — | Minnesota Twins | Minnesota Twins signed free agent IF Denyerbe Gervis to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Fredy Michel | — | Minnesota Twins | Minnesota Twins signed free agent IF Fredy Michel to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Edgardo Chaviel | — | Minnesota Twins | Minnesota Twins signed free agent LHP Edgardo Chaviel to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Ismael Perez | — | Minnesota Twins | Minnesota Twins signed free agent OF Ismael Perez to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Jose Olivares | — | Minnesota Twins | Minnesota Twins signed free agent RHP Jose Olivares to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Santo Martinez | — | Minnesota Twins | Minnesota Twins signed free agent IF Santo Martinez to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Andres Centeno | — | Minnesota Twins | Minnesota Twins signed free agent OF Andres Centeno to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Oscar Paredes | — | Minnesota Twins | Minnesota Twins signed free agent RHP Oscar Paredes to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Reynaldo Madrigal | — | Minnesota Twins | Minnesota Twins signed free agent OF Reynaldo Madrigal to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Rafael Cruz | — | Minnesota Twins | Minnesota Twins signed free agent IF Rafael Cruz to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Giovanny Rivero | — | Minnesota Twins | Minnesota Twins signed free agent C Giovanny Rivero to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Junior Del Valle | — | Minnesota Twins | Minnesota Twins signed free agent OF Junior Del Valle to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Deiner Contreras | — | Minnesota Twins | Minnesota Twins signed free agent C Deiner Contreras to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Cleiber Maldonado | — | Minnesota Twins | Minnesota Twins signed free agent LHP Cleiber Maldonado to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Hector Andrade | — | Minnesota Twins | Minnesota Twins signed free agent RHP Hector Andrade to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Kevin Villavicencio | — | New York Mets | New York Mets signed free agent SS Kevin Villavicencio to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Angel Guerrero | — | New York Mets | New York Mets signed free agent OF Angel Guerrero to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Ruben Yustiz | — | New York Mets | New York Mets signed free agent C Ruben Yustiz to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | David Osuna | — | New York Mets | New York Mets signed free agent RHP David Osuna to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Lenerd Ramos | — | New York Mets | New York Mets signed free agent RHP Lenerd Ramos to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Francis De Leon | — | New York Mets | New York Mets signed free agent OF Francis De Leon to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Yohairo Cuevas | — | New York Mets | New York Mets signed free agent OF Yohairo Cuevas to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Yoandy Perez | — | New York Mets | New York Mets signed free agent SS Yoandy Perez to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Isaac Lechuga | — | New York Mets | New York Mets signed free agent SS Isaac Lechuga to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Héctor Rodríguez | — | New York Mets | New York Mets signed free agent IF Hector Rodriguez to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Brian Sierra | — | New York Mets | New York Mets signed free agent IF Brian Sierra to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Jose Melendez | — | New York Mets | New York Mets signed free agent C Jose Melendez to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Jensy Silvestre | — | New York Mets | New York Mets signed free agent RHP Jensy Silvestre to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Yohenny Mata | — | New York Mets | New York Mets signed free agent SS Yohenny Mata to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Pedro Quintana | — | New York Mets | New York Mets signed free agent LHP Pedro Quintana to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Samuel Camacaro | — | New York Mets | New York Mets signed free agent IF Samuel Camacaro to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Juan Arnaud | — | New York Mets | New York Mets signed free agent RHP Juan Arnaud to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Diego Mosquera | — | New York Mets | New York Mets signed free agent IF Diego Mosquera to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Ricardo Baptist | — | New York Mets | New York Mets signed free agent RHP Ricardo Baptist to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Mike Ibarguen | — | New York Mets | New York Mets signed free agent OF Mike Ibarguen to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Joel Díaz | — | New York Mets | New York Mets signed free agent RHP Joel Diaz to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Frederick Marte | — | New York Mets | New York Mets signed free agent SS Frederick Marte to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Enyer Serrano | — | New York Mets | New York Mets signed free agent OF Enyer Serrano to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Ellian Nunez | — | New York Mets | New York Mets signed free agent RHP Ellian Nunez to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Juan Veliz | — | New York Mets | New York Mets signed free agent LHP Juan Veliz to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | David Davalillo | — | New York Mets | New York Mets signed free agent RHP David Davalillo to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Sebastian Castro | — | New York Mets | New York Mets signed free agent OF Sebastian Castro to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Manuel Guance | — | New York Mets | New York Mets signed free agent IF Manuel Guance to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Gustavo Marquez | — | New York Mets | New York Mets signed free agent OF Gustavo Marquez to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Welington Quintero | — | Chicago Cubs | Chicago Cubs signed free agent RHP Welington Quintero to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | David Olivo | — | Chicago Cubs | Chicago Cubs signed free agent RHP David Olivo to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Cristian Hernández | — | Chicago Cubs | Chicago Cubs signed free agent SS Cristian Hernandez to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Moisés Ballesteros | — | Chicago Cubs | Chicago Cubs signed free agent C Moises Ballesteros to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Oferman Hernandez | — | Chicago Cubs | Chicago Cubs signed free agent OF Oferman Hernandez to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Fredy Montenegro | — | Chicago Cubs | Chicago Cubs signed free agent C Fredy Montenegro to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Joel Sierra | — | Chicago Cubs | Chicago Cubs signed free agent RHP Joel Sierra to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Zhiorman Imbriano | — | Chicago Cubs | Chicago Cubs signed free agent LHP Zhiorman Imbriano to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Pedro Ramírez | — | Chicago Cubs | Chicago Cubs signed free agent SS Pedro Ramirez to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Ronny Corniell | — | Chicago Cubs | Chicago Cubs signed free agent RHP Ronny Corniell to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Kenneddy Delgado | — | Chicago Cubs | Chicago Cubs signed free agent RHP Kenneddy Delgado to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Daniel Ferreira | — | Chicago Cubs | Chicago Cubs signed free agent OF Daniel Ferreira to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Adrian Martinez | — | Chicago Cubs | Chicago Cubs signed free agent RHP Adrian Martinez to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Carlos Ramos | — | Chicago Cubs | Chicago Cubs signed free agent C Carlos Ramos to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Gabriel Agrazal | — | Chicago Cubs | Chicago Cubs signed free agent RHP Gabriel Agrazal to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Nick Longhi | — | Colorado Rockies | Colorado Rockies signed free agent OF Nick Longhi to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Michael Arias | — | Chicago Cubs | Chicago Cubs signed free agent SS Michael Arias to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Martin Gimenez | — | Toronto Blue Jays | Toronto Blue Jays signed free agent SS Martin Gimenez to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Pedro León | — | Houston Astros | Houston Astros signed free agent OF Pedro Leon to a minor league contract and invited him to spring training. |
| Jan 15, 2021 | Signed as free agent | Pedro Báez | — | Houston Astros | Houston Astros signed free agent RHP Pedro Baez. |
| Jan 15, 2021 | Signed as free agent | Aneudis George | — | Colorado Rockies | Colorado Rockies signed free agent P Aneudis George. |
| Jan 15, 2021 | Signed as free agent | Rony Cruz | — | Colorado Rockies | Colorado Rockies signed free agent P Rony Cruz. |
| Jan 15, 2021 | Signed as free agent | Jorluis Guerra | — | Colorado Rockies | Colorado Rockies signed free agent SS Jorluis Guerra. |
| Jan 15, 2021 | Signed as free agent | Luis Paredes | — | Colorado Rockies | Colorado Rockies signed free agent CF Luis Paredes. |
| Jan 15, 2021 | Signed as free agent | Redinson Gomez | — | Colorado Rockies | Colorado Rockies signed free agent P Redinson Gomez. |
| Jan 15, 2021 | Signed as free agent | Felix Tena | — | Colorado Rockies | Colorado Rockies signed free agent CF Felix Tena. |
| Jan 15, 2021 | Signed as free agent | Claudio Galva | — | Colorado Rockies | Colorado Rockies signed free agent P Claudio Galva. |
| Jan 15, 2021 | Signed as free agent | Cristian Benavides | — | Colorado Rockies | Colorado Rockies signed free agent P Cristian Benavides. |
| Jan 15, 2021 | Signed as free agent | Bryant Betancourt | — | Colorado Rockies | Colorado Rockies signed free agent C Bryant Betancourt. |
| Jan 15, 2021 | Signed as free agent | Bryan Mena | — | Colorado Rockies | Colorado Rockies signed free agent P Bryan Mena. |
| Jan 15, 2021 | Signed as free agent | David Rodriguez | — | Colorado Rockies | Colorado Rockies signed free agent C David Rodriguez. |
| Jan 15, 2021 | Signed as free agent | Jose Colina | — | Colorado Rockies | Colorado Rockies signed free agent SS Jose Colina. |
| Jan 15, 2021 | Signed as free agent | Bryan Perez | — | Colorado Rockies | Colorado Rockies signed free agent P Bryan Perez. |
| Jan 15, 2021 | Signed as free agent | Jordy Vargas | — | Colorado Rockies | Colorado Rockies signed free agent P Jordy Vargas. |
| Jan 15, 2021 | Signed as free agent | Gabriel Terrero | — | Colorado Rockies | Colorado Rockies signed free agent SS Gabriel Terrero. |
| Jan 15, 2021 | Signed as free agent | Wilmer Difo | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent 2B Wilmer Difo. |
| Jan 15, 2021 | Signed as free agent | Pedro León | — | Houston Astros | Houston Astros signed free agent OF Pedro Leon. |
| Jan 15, 2021 | Signed as free agent | Nick Longhi | — | Colorado Rockies | Colorado Rockies signed free agent 1B Nick Longhi. |
| Jan 15, 2021 | Signed as free agent | Jonathan Salazar | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent P Jonathan Salazar. |
| Jan 15, 2021 | Signed as free agent | Gustavo Armas | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent OF Gustavo Armas. |
| Jan 15, 2021 | Signed as free agent | Andy Perez | — | Colorado Rockies | Colorado Rockies signed free agent SS Andy Perez. |
| Jan 15, 2021 | Signed as free agent | Angel Lopez | — | Boston Red Sox | Boston Red Sox signed free agent P Angel Lopez. |
| Jan 15, 2021 | Signed as free agent | Andres Silvera | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent P Andres Silvera. |
| Jan 15, 2021 | Signed as free agent | Greiber Mendez | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent P Greiber Mendez. |
| Jan 15, 2021 | Signed as free agent | Liam Hendriks | — | Chicago White Sox | Chicago White Sox signed free agent P Liam Hendriks. |
| Jan 15, 2021 | Signed as free agent | Kurt Suzuki | — | Los Angeles Angels | Los Angeles Angels signed free agent C Kurt Suzuki. |
| Jan 15, 2021 | Signed as free agent | Liam Hendriks | — | Chicago White Sox | Chicago White Sox signed free agent P Liam Hendriks. |
| Jan 15, 2021 | Signed as free agent | Kurt Suzuki | — | Los Angeles Angels | Los Angeles Angels signed free agent C Kurt Suzuki. |
| Jan 15, 2021 | Signed as free agent | Edwin Hidalgo | — | Los Angeles Angels | Los Angeles Angels signed free agent C Edwin Hidalgo to a minor league contract. |
| Jan 15, 2021 | Signed as free agent | Liam Hendriks | — | Chicago White Sox | Chicago White Sox signed free agent RHP Liam Hendriks. |
| Jan 15, 2021 | Signed as free agent | Liam Hendriks | — | Chicago White Sox | Chicago White Sox signed free agent RHP Liam Hendriks, and. |
| Jan 15, 2021 | Signed as free agent | Unnamed | — | Texas Rangers | Texas Rangers signed free agent SS Yeferson Tineo to a minor league contract. |
| Jan 14, 2021 | Trade | Nik Turley | Pittsburgh Pirates | Athletics | Pittsburgh Pirates traded LHP Nik Turley to Oakland Athletics for cash. |
| Jan 14, 2021 | Signed as free agent | José A. Martínez | — | New York Mets | New York Mets signed free agent OF Jose Martinez. |
| Jan 14, 2021 | Signed as free agent | Alex Wood | — | San Francisco Giants | San Francisco Giants signed free agent LHP Alex Wood. |
| Jan 14, 2021 | Signed as free agent | Zach Mort | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Zach Mort to a minor league contract. |
| Jan 14, 2021 | Signed as free agent | Dillon Thomas | — | Seattle Mariners | Seattle Mariners signed free agent OF Dillon Thomas to a minor league contract. |
| Jan 14, 2021 | Signed as free agent | Enny Romero | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent LHP Enny Romero to a minor league contract and invited him to spring training. |
| Jan 14, 2021 | Signed as free agent | Ali Castillo | — | Washington Nationals | Washington Nationals signed free agent 3B Ali Castillo to a minor league contract. |
| Jan 14, 2021 | Signed as free agent | Kevin Moreno | — | Washington Nationals | Washington Nationals signed free agent OF Kevin Moreno to a minor league contract. |
| Jan 14, 2021 | Signed as free agent | Enny Romero | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent LHP Enny Romero to a minor league contract and invited him to spring training. |
| Jan 14, 2021 | Signed as free agent | Enny Romero | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent P Enny Romero. |
| Jan 13, 2021 | Signed as free agent | Drew Butera | — | Texas Rangers | Texas Rangers signed free agent C Drew Butera to a minor league contract and invited him to spring training. |
| Jan 13, 2021 | Signed as free agent | Justin Anderson | — | Texas Rangers | Texas Rangers signed free agent RHP Justin Anderson to a minor league contract and invited him to spring training. |
| Jan 13, 2021 | Signed as free agent | Jace Peterson | — | Milwaukee Brewers | Milwaukee Brewers signed free agent 3B Jace Peterson to a minor league contract and invited him to spring training. |
| Jan 13, 2021 | Signed as free agent | Justin Anderson | — | Texas Rangers | Texas Rangers signed free agent P Justin Anderson. |
| Jan 13, 2021 | Signed as free agent | Jace Peterson | — | Milwaukee Brewers | Milwaukee Brewers signed free agent 2B Jace Peterson. |
| Jan 12, 2021 | Signed as free agent | A.J. Cole | — | Toronto Blue Jays | Toronto Blue Jays signed free agent RHP A.J. Cole to a minor league contract and invited him to spring training. |
| Jan 12, 2021 | Signed as free agent | A.J. Cole | — | Toronto Blue Jays | Toronto Blue Jays signed free agent P A.J. Cole. |
| Jan 10, 2021 | Signed as free agent | David Masters | — | Seattle Mariners | Seattle Mariners signed free agent SS David Masters to a minor league contract. |
| Jan 9, 2021 | Trade | Carson Ragsdale | Philadelphia Phillies | San Francisco Giants | San Francisco Giants traded RHP Sam Coonrod to Philadelphia Phillies for RHP Carson Ragsdale. |
| Jan 9, 2021 | Signed as free agent | Kyle Schwarber | — | Washington Nationals | Washington Nationals signed free agent LF Kyle Schwarber. |
| Jan 9, 2021 | Signed as free agent | Rangel Ravelo | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent 1B Rangel Ravelo to a minor league contract and invited him to spring training. |
| Jan 9, 2021 | Signed as free agent | Rangel Ravelo | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent 1B Rangel Ravelo to a minor league contract and invited him to spring training. |
| Jan 9, 2021 | Signed as free agent | Rangel Ravelo | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent 1B Rangel Ravelo. |
| Jan 8, 2021 | Signed as free agent | Roenis Elías | — | Seattle Mariners | Seattle Mariners signed free agent LHP Roenis Elias to a minor league contract. |
| Jan 8, 2021 | Signed as free agent | Jantzen Witte | — | Seattle Mariners | Seattle Mariners signed free agent 3B Jantzen Witte to a minor league contract. |
| Jan 8, 2021 | Signed as free agent | Paul Sewald | — | Seattle Mariners | Seattle Mariners signed free agent RHP Paul Sewald to a minor league contract. |
| Jan 8, 2021 | Signed as free agent | Mike Kickham | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent LHP Mike Kickham to a minor league contract and invited him to spring training. |
| Jan 8, 2021 | Signed as free agent | Mike Kickham | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent LHP Mike Kickham to a minor league contract and invited him to spring training. |
| Jan 8, 2021 | Signed as free agent | Peter Tago | — | Chicago White Sox | Chicago White Sox signed free agent P Peter Tago. |
| Jan 8, 2021 | Signed as free agent | Mike Kickham | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent P Mike Kickham. |
| Jan 7, 2021 | Signed as free agent | Miguel Del Pozo | — | Detroit Tigers | Detroit Tigers signed free agent LHP Miguel Del Pozo to a minor league contract. |
| Jan 7, 2021 | Signed as free agent | Pablo Reyes | — | Milwaukee Brewers | Milwaukee Brewers signed free agent OF Pablo Reyes to a minor league contract and invited him to spring training. |
| Jan 7, 2021 | Signed as free agent | Ryne Stanek | — | Houston Astros | Houston Astros signed free agent RHP Ryne Stanek. |
| Jan 7, 2021 | Signed as free agent | Nick Shumpert | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent SS Nicholas Shumpert to a minor league contract. |
| Jan 7, 2021 | Signed as free agent | Pete Bayer | — | Cincinnati Reds | Cincinnati Reds signed free agent RHP Peter Bayer to a minor league contract. |
| Jan 7, 2021 | Signed as free agent | Pablo Reyes | — | Milwaukee Brewers | Milwaukee Brewers signed free agent OF Pablo Reyes to a minor league contract and invited him to spring training. |
| Jan 7, 2021 | Signed as free agent | Pablo Reyes | — | Milwaukee Brewers | Milwaukee Brewers signed free agent 3B Pablo Reyes. |
| Jan 7, 2021 | Trade | Francisco Lindor | — | New York Mets | traded SS Francisco Lindor to New York Mets. |
| Jan 7, 2021 | Signed as free agent | Ryne Stanek | — | Houston Astros | Houston Astros signed free agent P Ryne Stanek. |
| Jan 7, 2021 | Signed as free agent | Ryne Stanek | — | Houston Astros | Houston Astros signed free agent RHP Ryne Stanek. |
| Jan 6, 2021 | Trade | Greg Allen | San Diego Padres | New York Yankees | San Diego Padres traded LF Greg Allen to New York Yankees for James Reeves. |
| Jan 6, 2021 | Signed as free agent | Sócrates Brito | — | New York Yankees | New York Yankees signed free agent OF Socrates Brito to a minor league contract and invited him to spring training. |
| Jan 6, 2021 | Trade | Art Warren | Texas Rangers | Cincinnati Reds | Texas Rangers traded RHP Art Warren to Cincinnati Reds for cash. |
| Jan 6, 2021 | Signed as free agent | Jhoulys Chacín | — | New York Yankees | New York Yankees signed free agent RHP Jhoulys Chacin to a minor league contract and invited him to spring training. |
| Jan 6, 2021 | Signed as free agent | Tyler Lyons | — | New York Yankees | New York Yankees signed free agent LHP Tyler Lyons to a minor league contract and invited him to spring training. |
| Jan 6, 2021 | Signed as free agent | Elliot Soto | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent SS Elliot Soto to a minor league contract and invited him to spring training. |
| Jan 6, 2021 | Signed as free agent | Elliot Soto | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent SS Elliot Soto to a minor league contract and invited him to spring training. |
| Jan 6, 2021 | Signed as free agent | Sócrates Brito | — | New York Yankees | New York Yankees signed free agent RF Socrates Brito. |
| Jan 6, 2021 | Signed as free agent | Tyler Lyons | — | New York Yankees | New York Yankees signed free agent P Tyler Lyons. |
| Jan 6, 2021 | Signed as free agent | Elliot Soto | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent SS Elliot Soto. |
| Jan 6, 2021 | Signed as free agent | Alberto Baldonado | — | Washington Nationals | Washington Nationals signed free agent LHP Alberto Baldonado to a minor league contract. |
| Jan 5, 2021 | Trade | Carl Chester | Tampa Bay Rays | Texas Rangers | Tampa Bay Rays traded LF Carl Chester to Texas Rangers. |
| Jan 5, 2021 | Signed as free agent | Drew Anderson | — | Texas Rangers | Texas Rangers signed free agent RHP Drew Anderson to a minor league contract and invited him to spring training. |
| Jan 5, 2021 | Signed as free agent | Robbie Grossman | — | Detroit Tigers | Detroit Tigers signed free agent LF Robbie Grossman. |
| Jan 5, 2021 | Signed as free agent | Blake Treinen | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Blake Treinen. |
| Jan 5, 2021 | Signed as free agent | Patrick Wisdom | — | Chicago Cubs | Chicago Cubs signed free agent 1B Patrick Wisdom to a minor league contract and invited him to spring training. |
| Jan 5, 2021 | Signed as free agent | Andrew Velazquez | — | New York Yankees | New York Yankees signed free agent 3B Andrew Velazquez to a minor league contract and invited him to spring training. |
| Jan 5, 2021 | Signed as free agent | Chase De Jong | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent RHP Chase De Jong to a minor league contract and invited him to spring training. |
| Jan 5, 2021 | Signed as free agent | Kevin Munson | — | Seattle Mariners | Seattle Mariners signed free agent RHP Kevin Munson to a minor league contract. |
| Jan 5, 2021 | Signed as free agent | Brandon Drury | — | New York Mets | New York Mets signed free agent 3B Brandon Drury to a minor league contract and invited him to spring training. |
| Jan 5, 2021 | Signed as free agent | Seth Frankoff | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Seth Frankoff to a minor league contract and invited him to spring training. |
| Jan 5, 2021 | Trade | Greg Allen | — | New York Yankees | traded to New York Yankees for . |
| Jan 5, 2021 | Signed as free agent | Patrick Wisdom | — | Chicago Cubs | Chicago Cubs signed free agent 1B Patrick Wisdom to a minor league contract and invited him to spring training. |
| Jan 5, 2021 | Signed as free agent | Seth Frankoff | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent RHP Seth Frankoff to a minor league contract and invited him to spring training. |
| Jan 5, 2021 | Signed as free agent | Arismendy Alcántara | — | San Francisco Giants | San Francisco Giants signed free agent 2B Arismendy Alcantara to a minor league contract and invited him to spring training. |
| Jan 5, 2021 | Signed as free agent | Drew Anderson | — | Texas Rangers | Texas Rangers signed free agent P Drew Anderson. |
| Jan 5, 2021 | Signed as free agent | Arismendy Alcántara | — | San Francisco Giants | San Francisco Giants signed free agent CF Arismendy Alcantara. |
| Jan 5, 2021 | Signed as free agent | Chase De Jong | — | Pittsburgh Pirates | Pittsburgh Pirates signed free agent P Chase De Jong. |
| Jan 5, 2021 | Signed as free agent | Andrew Velazquez | — | New York Yankees | New York Yankees signed free agent SS Andrew Velazquez. |
| Jan 5, 2021 | Signed as free agent | Brandon Drury | — | New York Mets | New York Mets signed free agent 2B Brandon Drury. |
| Jan 5, 2021 | Signed as free agent | Patrick Wisdom | — | Chicago Cubs | Chicago Cubs signed free agent 3B Patrick Wisdom. |
| Jan 5, 2021 | Signed as free agent | Seth Frankoff | — | Arizona Diamondbacks | Arizona Diamondbacks signed free agent P Seth Frankoff. |
| Jan 5, 2021 | Signed as free agent | Blake Treinen | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent P Blake Treinen. |
| Jan 5, 2021 | Signed as free agent | Robbie Grossman | — | Detroit Tigers | Detroit Tigers signed free agent LF Robbie Grossman. |
| Jan 5, 2021 | Signed as free agent | Blake Treinen | — | Los Angeles Dodgers | Los Angeles Dodgers signed free agent RHP Blake Treinen, and. |
| Jan 5, 2021 | Signed as free agent | Unnamed | — | Detroit Tigers | Detroit Tigers signed free agent LF Robbie Grossman, and. |
| Jan 5, 2021 | Signed as free agent | Joe DeCarlo | — | Chicago White Sox | Chicago White Sox signed free agent 3B Joe DeCarlo to a minor league contract. |
| Jan 4, 2021 | Signed as free agent | Christian Bethancourt | — | Philadelphia Phillies | Philadelphia Phillies signed free agent C Christian Bethancourt to a minor league contract and invited him to spring training. |
| Jan 4, 2021 | Signed as free agent | Neftalí Feliz | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RHP Neftali Feliz to a minor league contract and invited him to spring training. |
| Jan 4, 2021 | Signed as free agent | Ronald Torreyes | — | Philadelphia Phillies | Philadelphia Phillies signed free agent 2B Ronald Torreyes to a minor league contract and invited him to spring training. |
| Jan 4, 2021 | Signed as free agent | Michael Ynoa | — | Philadelphia Phillies | Philadelphia Phillies signed free agent RHP Michael Ynoa to a minor league contract and invited him to spring training. |
| Jan 4, 2021 | Signed as free agent | Curt Casali | — | San Francisco Giants | San Francisco Giants signed free agent C Curt Casali. |
| Jan 4, 2021 | Released | Andrew Suárez | — | San Francisco Giants | San Francisco Giants released LHP Andrew Suarez. |
| Jan 4, 2021 | Released | Colin Rea | — | Chicago Cubs | Chicago Cubs released RHP Colin Rea. |
| Jan 4, 2021 | Signed as free agent | Zack Kelly | — | Boston Red Sox | Boston Red Sox signed free agent RHP Zack Kelly to a minor league contract. |
| Jan 4, 2021 | Signed as free agent | Jeremy Rivera | — | Boston Red Sox | Boston Red Sox signed free agent SS Jeremy Rivera to a minor league contract. |
| Jan 4, 2021 | Signed as free agent | Erick Mejia | — | Kansas City Royals | Kansas City Royals signed free agent 2B Erick Mejia to a minor league contract. |
| Jan 4, 2021 | Signed as free agent | Luis Perdomo | — | Milwaukee Brewers | Milwaukee Brewers signed free agent RHP Luis Perdomo to a minor league contract. |
| Jan 4, 2021 | Signed as free agent | Nestor Cortes | — | New York Yankees | New York Yankees signed free agent LHP Nestor Cortes to a minor league contract and invited him to spring training. |
| Jan 4, 2021 | Signed as free agent | Luis Avilán | — | Washington Nationals | Washington Nationals signed free agent LHP Luis Avilan to a minor league contract and invited him to spring training. |
| Jan 4, 2021 | Signed as free agent | Curt Casali | — | San Francisco Giants | San Francisco Giants signed free agent C Curt Casali. |
| Jan 4, 2021 | Signed as free agent | Ronald Torreyes | — | Philadelphia Phillies | Philadelphia Phillies signed free agent SS Ronald Torreyes. |
| Jan 4, 2021 | Signed as free agent | Neftalí Feliz | — | Philadelphia Phillies | Philadelphia Phillies signed free agent P Neftali Feliz. |
| Jan 4, 2021 | Signed as free agent | Nestor Cortes | — | New York Yankees | New York Yankees signed free agent P Nestor Cortes. |
| Jan 4, 2021 | Signed as free agent | Curt Casali | — | San Francisco Giants | San Francisco Giants signed free agent C Curt Casali. |
| Jan 4, 2021 | Signed as free agent | Curt Casali | — | San Francisco Giants | San Francisco Giants signed free agent C Curt Casali. |
| Jan 3, 2021 | Signed as free agent | Ross Detwiler | — | Miami Marlins | Miami Marlins signed free agent LHP Ross Detwiler. |
| Jan 3, 2021 | Signed as free agent | Sandy León | — | Miami Marlins | Miami Marlins signed free agent C Sandy Leon to a minor league contract and invited him to spring training. |
| Jan 3, 2021 | Signed as free agent | Ross Detwiler | — | Miami Marlins | Miami Marlins signed free agent LHP Ross Detwiler. |
| Jan 3, 2021 | Signed as free agent | Sandy León | — | Miami Marlins | Miami Marlins signed free agent C Sandy Leon to a minor league contract and invited him to spring training. |
| Jan 3, 2021 | Signed as free agent | Sandy León | — | Miami Marlins | Miami Marlins signed free agent C Sandy Leon. |
| Jan 3, 2021 | Signed as free agent | Ross Detwiler | — | Miami Marlins | Miami Marlins signed free agent P Ross Detwiler. |
| Jan 3, 2021 | Signed as free agent | Ross Detwiler | — | Miami Marlins | Miami Marlins signed free agent LHP Ross Detwiler. |
| Jan 2, 2021 | Signed as free agent | Nick Martini | — | Chicago Cubs | Chicago Cubs signed free agent OF Nick Martini to a minor league contract and invited him to spring training. |
| Jan 2, 2021 | Signed as free agent | Nick Martini | — | Chicago Cubs | Chicago Cubs signed free agent OF Nick Martini to a minor league contract and invited him to spring training. |
| Jan 2, 2021 | Signed as free agent | Nick Martini | — | Chicago Cubs | Chicago Cubs signed free agent LF Nick Martini. |
Every row is captured from MLB’s official StatsAPI transactions feed with MLB’s published description unedited. Signings include both major-league and minor-league contracts signed with a major-league club; injury-list moves and minor-league affiliate-only transactions are outside this archive’s scope.
Transaction data: official MLB StatsAPI. Data provided by MLB Advanced Media. Archived and published by Legends Deck.