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The 2010 season’s official transaction log: 1,275 trades, signings and releases involving major-league clubs, listed newest first.
| Date | Type | Player | From | To | Details |
|---|---|---|---|---|---|
| Dec 31, 2010 | Signed as free agent | Zach Miner | — | Kansas City Royals | Free agent signing |
| Dec 27, 2010 | Trade | Chin-lung Hu | Los Angeles Dodgers | New York Mets | Trade |
| Dec 27, 2010 | Trade | Mike Antonini | New York Mets | Los Angeles Dodgers | Trade |
| Dec 23, 2010 | Signed as free agent | Xavier Cedeno | — | Houston Astros | Free agent signing |
| Dec 23, 2010 | Signed as free agent | Tug Hulett | — | Colorado Rockies | Free agent signing |
| Dec 23, 2010 | Signed as free agent | Jeff Salazar | — | Colorado Rockies | Free agent signing |
| Dec 23, 2010 | Trade | Matt Lindstrom | Houston Astros | Colorado Rockies | Trade |
| Dec 23, 2010 | Trade | Jonnathan Aristil | Colorado Rockies | Houston Astros | Trade |
| Dec 23, 2010 | Trade | Wes Musick | Colorado Rockies | Houston Astros | Trade |
| Dec 23, 2010 | Signed as free agent | Zach Jackson | — | Texas Rangers | Free agent signing |
| Dec 23, 2010 | Signed as free agent | Omar Quintanilla | — | Texas Rangers | Free agent signing |
| Dec 23, 2010 | Signed as free agent | Steve Holm | — | Minnesota Twins | Free agent signing |
| Dec 23, 2010 | Signed as free agent | Rene Rivera | — | Minnesota Twins | Free agent signing |
| Dec 23, 2010 | Signed as free agent | Harvey Garcia | — | Washington Nationals | Free agent signing |
| Dec 23, 2010 | Signed as free agent | Carlos Maldonado | — | Washington Nationals | Free agent signing |
| Dec 23, 2010 | Signed as free agent | Matt Macri | — | Colorado Rockies | Free agent signing |
| Dec 23, 2010 | Signed as free agent | Casey Daigle | — | San Francisco Giants | Free agent signing |
| Dec 23, 2010 | Released | Anthony Lerew | Oakland Athletics | — | Release |
| Dec 23, 2010 | Trade | Ryan Kelly | Pittsburgh Pirates | Oakland Athletics | Trade |
| Dec 23, 2010 | Trade | Corey Wimberly | Oakland Athletics | Pittsburgh Pirates | Trade |
| Dec 22, 2010 | Signed as free agent | Sean Green | — | Milwaukee Brewers | Free agent signing |
| Dec 22, 2010 | Signed as free agent | Gustavo Chacin | — | Houston Astros | Free agent signing |
| Dec 22, 2010 | Signed as free agent | Craig Counsell | — | Milwaukee Brewers | Free agent signing |
| Dec 22, 2010 | Released | Brent Leach | Los Angeles Dodgers | — | Release |
| Dec 22, 2010 | Signed as free agent | Yohan Flande | — | Atlanta Braves | Free agent signing |
| Dec 21, 2010 | Signed as free agent | Jim Henderson | — | Milwaukee Brewers | Free agent signing |
| Dec 21, 2010 | Signed as free agent | Rich Harden | — | Oakland Athletics | Free agent signing |
| Dec 21, 2010 | Signed as free agent | Corey Patterson | — | Toronto Blue Jays | Free agent signing |
| Dec 21, 2010 | Signed as free agent | Rick Ankiel | — | Washington Nationals | Free agent signing |
| Dec 21, 2010 | Signed as free agent | Travis Buck | — | Cleveland Indians | Free agent signing |
| Dec 21, 2010 | Signed as free agent | Bobby Jenks | — | Boston Red Sox | Free agent signing |
| Dec 21, 2010 | Signed as free agent | Michel Hernandez | — | Baltimore Orioles | Free agent signing |
| Dec 21, 2010 | Signed | Leonel Campos | — | San Diego Padres | Amateur free agent signing |
| Dec 21, 2010 | Signed as free agent | Dustin Molleken | — | Colorado Rockies | Free agent signing |
| Dec 20, 2010 | Signed as free agent | Billy Buckner | — | Colorado Rockies | Free agent signing |
| Dec 20, 2010 | Signed as free agent | Alberto Castillo | — | Baltimore Orioles | Free agent signing |
| Dec 20, 2010 | Signed as free agent | Mike Cervenak | — | Florida Marlins | Free agent signing |
| Dec 20, 2010 | Released | German Duran | Houston Astros | — | Release |
| Dec 20, 2010 | Signed as free agent | Josh Fields | — | Pittsburgh Pirates | Free agent signing |
| Dec 20, 2010 | Signed as free agent | Chris George | — | Baltimore Orioles | Free agent signing |
| Dec 20, 2010 | Signed as free agent | Bill Hall | — | Houston Astros | Free agent signing |
| Dec 20, 2010 | Signed as free agent | Austin Kearns | — | Cleveland Indians | Free agent signing |
| Dec 20, 2010 | Signed as free agent | Steven Lerud | — | Baltimore Orioles | Free agent signing |
| Dec 20, 2010 | Signed as free agent | Edwin Maysonet | — | Milwaukee Brewers | Free agent signing |
| Dec 20, 2010 | Signed as free agent | Michael Aubrey | — | Washington Nationals | Free agent signing |
| Dec 20, 2010 | Signed as free agent | Chuck James | — | Minnesota Twins | Free agent signing |
| Dec 20, 2010 | Signed as free agent | Jesse Crain | — | Chicago White Sox | Free agent signing |
| Dec 20, 2010 | Signed as free agent | Orlando Hudson | — | San Diego Padres | Free agent signing |
| Dec 20, 2010 | Signed as free agent | Brian Stokes | — | Toronto Blue Jays | Free agent signing |
| Dec 20, 2010 | Signed as free agent | Argenis Diaz | — | Detroit Tigers | Free agent signing |
| Dec 20, 2010 | Signed as free agent | Tyler Yates | — | Pittsburgh Pirates | Free agent signing |
| Dec 20, 2010 | Signed as free agent | Ryan Braun | — | Los Angeles Angels of Anaheim | Free agent signing |
| Dec 20, 2010 | Signed as free agent | Matthew Brown | — | Minnesota Twins | Free agent signing |
| Dec 20, 2010 | Signed as free agent | Brian Barton | — | Cincinnati Reds | Free agent signing |
| Dec 20, 2010 | Signed as free agent | Jumbo Diaz | — | Baltimore Orioles | Free agent signing |
| Dec 19, 2010 | Signed as free agent | Ryan Budde | — | Toronto Blue Jays | Free agent signing |
| Dec 19, 2010 | Trade | Unnamed | Kansas City Royals | Milwaukee Brewers | $ |
| Dec 19, 2010 | Trade | Zack Greinke | Kansas City Royals | Milwaukee Brewers | Trade |
| Dec 19, 2010 | Trade | Yuniesky Betancourt | Kansas City Royals | Milwaukee Brewers | Trade |
| Dec 19, 2010 | Trade | Jeremy Jeffress | Milwaukee Brewers | Kansas City Royals | Trade |
| Dec 19, 2010 | Trade | Alcides Escobar | Milwaukee Brewers | Kansas City Royals | Trade |
| Dec 19, 2010 | Trade | Lorenzo Cain | Milwaukee Brewers | Kansas City Royals | Trade |
| Dec 19, 2010 | Trade | Jake Odorizzi | Milwaukee Brewers | Kansas City Royals | Trade |
| Dec 19, 2010 | Signed as free agent | Luis Vizcaino | — | New York Yankees | Free agent signing |
| Dec 19, 2010 | Signed as free agent | Guillermo Mota | — | San Francisco Giants | Free agent signing |
| Dec 18, 2010 | Signed as free agent | Michael Hollimon | — | Minnesota Twins | Free agent signing |
| Dec 18, 2010 | Signed as free agent | Mike Jacobs | — | Colorado Rockies | Free agent signing |
| Dec 18, 2010 | Signed as free agent | Dan Wheeler | — | Boston Red Sox | Free agent signing |
| Dec 18, 2010 | Signed as free agent | Endy Chavez | — | Texas Rangers | Free agent signing |
| Dec 18, 2010 | Signed as free agent | Brian Barden | — | Texas Rangers | Free agent signing |
| Dec 18, 2010 | Signed as free agent | Seth McClung | — | Texas Rangers | Free agent signing |
| Dec 17, 2010 | Signed as free agent | Matt Antonelli | — | Washington Nationals | Free agent signing |
| Dec 17, 2010 | Signed as free agent | Brian Gordon | — | Philadelphia Phillies | Free agent signing |
| Dec 17, 2010 | Released | Rusty Ryal | Arizona Diamondbacks | — | Release |
| Dec 17, 2010 | Trade | Jason Bartlett | Tampa Bay Rays | San Diego Padres | Trade |
| Dec 17, 2010 | Trade | Adam Russell | San Diego Padres | Tampa Bay Rays | Trade |
| Dec 17, 2010 | Trade | Cesar Ramos | San Diego Padres | Tampa Bay Rays | Trade |
| Dec 17, 2010 | Trade | Cole Figueroa | San Diego Padres | Tampa Bay Rays | Trade |
| Dec 17, 2010 | Trade | Brandon Gomes | San Diego Padres | Tampa Bay Rays | Trade |
| Dec 17, 2010 | Signed as free agent | Chad Gaudin | — | Washington Nationals | Free agent signing |
| Dec 17, 2010 | Signed as free agent | Magglio Ordonez | — | Detroit Tigers | Free agent signing |
| Dec 17, 2010 | Signed as free agent | Kerry Wood | — | Chicago Cubs | Free agent signing |
| Dec 17, 2010 | Signed as free agent | Jeremy Accardo | — | Baltimore Orioles | Free agent signing |
| Dec 17, 2010 | Signed as free agent | Xavier Nady | — | Arizona Diamondbacks | Free agent signing |
| Dec 17, 2010 | Signed as free agent | Henry Blanco | — | Arizona Diamondbacks | Free agent signing |
| Dec 17, 2010 | Signed as free agent | Kevin Correia | — | Pittsburgh Pirates | Free agent signing |
| Dec 17, 2010 | Signed as free agent | Joel Peralta | — | Tampa Bay Rays | Free agent signing |
| Dec 17, 2010 | Signed as free agent | Fernando Cabrera | — | Oakland Athletics | Free agent signing |
| Dec 17, 2010 | Signed as free agent | Clay Timpner | — | Detroit Tigers | Free agent signing |
| Dec 16, 2010 | Signed as free agent | Yhency Brazoban | — | Texas Rangers | Free agent signing |
| Dec 16, 2010 | Signed as free agent | Edwin Encarnacion | — | Toronto Blue Jays | Free agent signing |
| Dec 16, 2010 | Signed as free agent | Rich Hill | — | Boston Red Sox | Free agent signing |
| Dec 16, 2010 | Signed as free agent | Andrew Miller | — | Boston Red Sox | Free agent signing |
| Dec 16, 2010 | Signed as free agent | Chien-Ming Wang | — | Washington Nationals | Free agent signing |
| Dec 16, 2010 | Signed as free agent | Randy Williams | — | Boston Red Sox | Free agent signing |
| Dec 16, 2010 | Trade | Jose Morales | Minnesota Twins | Colorado Rockies | Trade |
| Dec 16, 2010 | Trade | Paul Bargas | Colorado Rockies | Minnesota Twins | Trade |
| Dec 16, 2010 | Trade | Josh Willingham | Washington Nationals | Oakland Athletics | Trade |
| Dec 16, 2010 | Trade | Henry Rodriguez | Oakland Athletics | Washington Nationals | Trade |
| Dec 16, 2010 | Trade | Corey Brown | Oakland Athletics | Washington Nationals | Trade |
| Dec 16, 2010 | Trade | Eric Patterson | Boston Red Sox | San Diego Padres | Trade |
| Dec 16, 2010 | Signed as free agent | Adam Everett | — | Cleveland Indians | Free agent signing |
| Dec 16, 2010 | Signed as free agent | Matt Albers | — | Boston Red Sox | Free agent signing |
| Dec 16, 2010 | Signed as free agent | Matt Guerrier | — | Los Angeles Dodgers | Free agent signing |
| Dec 16, 2010 | Signed as free agent | Lenny DiNardo | — | Boston Red Sox | Free agent signing |
| Dec 16, 2010 | Signed as free agent | Phillips Valdez | — | Tampa Bay Rays | Free agent signing |
| Dec 15, 2010 | Signed as free agent | Randy Choate | — | Florida Marlins | Free agent signing |
| Dec 15, 2010 | Signed as free agent | Gustavo Molina | — | New York Yankees | Free agent signing |
| Dec 15, 2010 | Signed as free agent | Jose Quintana | — | New York Yankees | Free agent signing |
| Dec 15, 2010 | Signed as free agent | Mark Prior | — | New York Yankees | Free agent signing |
| Dec 15, 2010 | Signed as free agent | Russell Martin | — | New York Yankees | Free agent signing |
| Dec 15, 2010 | Signed as free agent | Sammy Gervacio | — | Houston Astros | Free agent signing |
| Dec 15, 2010 | Signed as free agent | Cliff Lee | — | Philadelphia Phillies | Free agent signing |
| Dec 15, 2010 | Signed as free agent | Vinnie Chulk | — | Oakland Athletics | Free agent signing |
| Dec 15, 2010 | Signed as free agent | Andy Tracy | — | Arizona Diamondbacks | Free agent signing |
| Dec 15, 2010 | Signed as free agent | Doug Bernier | — | New York Yankees | Free agent signing |
| Dec 15, 2010 | Signed as free agent | Toru Murata | — | Cleveland Indians | Free agent signing with first major-league team |
| Dec 14, 2010 | Signed as free agent | Denny Bautista | — | Seattle Mariners | Free agent signing |
| Dec 14, 2010 | Signed as free agent | Juan Castro | — | Los Angeles Dodgers | Free agent signing |
| Dec 14, 2010 | Signed as free agent | Matt Diaz | — | Pittsburgh Pirates | Free agent signing |
| Dec 14, 2010 | Released | Alfredo Figaro | Detroit Tigers | — | Release |
| Dec 14, 2010 | Signed as free agent | Gerald Laird | — | St. Louis Cardinals | Free agent signing |
| Dec 14, 2010 | Signed as free agent | Hideki Matsui | — | Oakland Athletics | Free agent signing |
| Dec 14, 2010 | Signed as free agent | Brandon McCarthy | — | Oakland Athletics | Free agent signing |
| Dec 14, 2010 | Signed as free agent | Dioner Navarro | — | Los Angeles Dodgers | Free agent signing |
| Dec 14, 2010 | Signed as free agent | Lyle Overbay | — | Pittsburgh Pirates | Free agent signing |
| Dec 14, 2010 | Signed as free agent | Royce Ring | — | Seattle Mariners | Free agent signing |
| Dec 14, 2010 | Signed as free agent | Matt Stairs | — | Washington Nationals | Free agent signing |
| Dec 14, 2010 | Signed as free agent | Andy Van Hekken | — | Houston Astros | Free agent signing |
| Dec 14, 2010 | Signed as free agent | Ryan Langerhans | — | Seattle Mariners | Free agent signing |
| Dec 14, 2010 | Signed as free agent | Chris Gimenez | — | Seattle Mariners | Free agent signing |
| Dec 14, 2010 | Released | Travis Blackley | Oakland Athletics | — | Release |
| Dec 13, 2010 | Signed as free agent | J. P. Howell | — | Tampa Bay Rays | Free agent signing |
| Dec 13, 2010 | Signed as free agent | Matt Treanor | — | Texas Rangers | Free agent signing |
| Dec 13, 2010 | Signed as free agent | Koji Uehara | — | Baltimore Orioles | Free agent signing |
| Dec 13, 2010 | Signed as free agent | Eugenio Velez | — | Los Angeles Dodgers | Free agent signing |
| Dec 13, 2010 | Signed as free agent | Dustin Moseley | — | San Diego Padres | Free agent signing |
| Dec 13, 2010 | Released | Caleb Thielbar | Milwaukee Brewers | — | Release |
| Dec 13, 2010 | Signed | Pedro Severino | — | Washington Nationals | Amateur free agent signing |
| Dec 13, 2010 | Signed | Ricardo Rodriguez | — | Texas Rangers | Amateur free agent signing |
| Dec 12, 2010 | Trade | Brendan Ryan | St. Louis Cardinals | Seattle Mariners | Trade |
| Dec 12, 2010 | Trade | Maikel Cleto | Seattle Mariners | St. Louis Cardinals | Trade |
| Dec 12, 2010 | Released | David Patton | Chicago Cubs | — | Release |
| Dec 12, 2010 | Signed as free agent | Chris Oxspring | — | Detroit Tigers | Free agent signing |
| Dec 11, 2010 | Signed as free agent | Carl Crawford | — | Boston Red Sox | Free agent signing |
| Dec 11, 2010 | Signed as free agent | Tony Gwynn | — | Los Angeles Dodgers | Free agent signing |
| Dec 10, 2010 | Released | Jeff Baisley | Oakland Athletics | — | Release |
| Dec 10, 2010 | Signed as free agent | Jonah Bayliss | — | Tampa Bay Rays | Free agent signing |
| Dec 10, 2010 | Signed as free agent | Joe Bisenius | — | Washington Nationals | Free agent signing |
| Dec 10, 2010 | Signed as free agent | Buck Coats | — | Washington Nationals | Free agent signing |
| Dec 10, 2010 | Signed as free agent | Scott Downs | — | Los Angeles Angels of Anaheim | Free agent signing |
| Dec 10, 2010 | Signed as free agent | Wil Nieves | — | Milwaukee Brewers | Free agent signing |
| Dec 10, 2010 | Signed as free agent | Jonathan Van Every | — | Washington Nationals | Free agent signing |
| Dec 10, 2010 | Signed as free agent | Donnie Veal | — | Pittsburgh Pirates | Free agent signing |
| Dec 10, 2010 | Signed as free agent | Jason Varitek | — | Boston Red Sox | Free agent signing |
| Dec 10, 2010 | Signed as free agent | George Sherrill | — | Atlanta Braves | Free agent signing |
| Dec 10, 2010 | Signed as free agent | Melky Cabrera | — | Kansas City Royals | Free agent signing |
| Dec 10, 2010 | Signed as free agent | Scott Olsen | — | Pittsburgh Pirates | Free agent signing |
| Dec 10, 2010 | Signed as free agent | Jack Cust | — | Seattle Mariners | Free agent signing |
| Dec 10, 2010 | Signed as free agent | Ryan Rowland-Smith | — | Houston Astros | Free agent signing |
| Dec 9, 2010 | Trade | Cesar Valdez | Arizona Diamondbacks | Pittsburgh Pirates | Trade |
| Dec 9, 2010 | Trade | Jim Hoey | Baltimore Orioles | Minnesota Twins | Trade |
| Dec 9, 2010 | Trade | Brett Jacobson | Baltimore Orioles | Minnesota Twins | Trade |
| Dec 9, 2010 | Trade | J. J. Hardy | Minnesota Twins | Baltimore Orioles | Trade |
| Dec 9, 2010 | Trade | Brendan Harris | Minnesota Twins | Baltimore Orioles | Trade |
| Dec 9, 2010 | Signed as free agent | Ronny Paulino | — | New York Mets | Free agent signing |
| Dec 9, 2010 | Signed as free agent | D. J. Carrasco | — | New York Mets | Free agent signing |
| Dec 9, 2010 | Signed as free agent | Vicente Padilla | — | Los Angeles Dodgers | Free agent signing |
| Dec 9, 2010 | Signed | Jose Leclerc | — | Texas Rangers | Amateur free agent signing |
| Dec 8, 2010 | Signed as free agent | Boof Bonser | — | New York Mets | Free agent signing |
| Dec 8, 2010 | Signed as free agent | Miguel Cairo | — | Cincinnati Reds | Free agent signing |
| Dec 8, 2010 | Signed as free agent | Jeff Francoeur | — | Kansas City Royals | Free agent signing |
| Dec 8, 2010 | Signed as free agent | Mike Hampton | — | Arizona Diamondbacks | Free agent signing |
| Dec 8, 2010 | Signed as free agent | Paul Konerko | — | Chicago White Sox | Free agent signing |
| Dec 8, 2010 | Signed as free agent | Carlos Peña | — | Chicago Cubs | Free agent signing |
| Dec 8, 2010 | Signed as free agent | Paul Phillips | — | Cleveland Indians | Free agent signing |
| Dec 7, 2010 | Signed as free agent | Derek Jeter | — | New York Yankees | Free agent signing |
| Dec 7, 2010 | Signed as free agent | J. J. Putz | — | Arizona Diamondbacks | Free agent signing |
| Dec 7, 2010 | Signed as free agent | Ty Wigginton | — | Colorado Rockies | Free agent signing |
| Dec 7, 2010 | Signed as free agent | Mariano Rivera | — | New York Yankees | Free agent signing |
| Dec 7, 2010 | Released | Yohan Flande | Philadelphia Phillies | — | Release |
| Dec 6, 2010 | Signed as free agent | Russ Adams | — | New York Mets | Free agent signing |
| Dec 6, 2010 | Signed as free agent | Melvin Mora | — | Arizona Diamondbacks | Free agent signing |
| Dec 6, 2010 | Signed as free agent | Trent Oeltjen | — | Los Angeles Dodgers | Free agent signing |
| Dec 6, 2010 | Signed as free agent | Stu Pomeranz | — | Los Angeles Dodgers | Free agent signing |
| Dec 6, 2010 | Signed as free agent | Dusty Ryan | — | New York Mets | Free agent signing |
| Dec 6, 2010 | Signed as free agent | Omir Santos | — | Detroit Tigers | Free agent signing |
| Dec 6, 2010 | Trade | Mark Reynolds | Arizona Diamondbacks | Baltimore Orioles | Trade |
| Dec 6, 2010 | Trade | David Hernandez | Baltimore Orioles | Arizona Diamondbacks | Trade |
| Dec 6, 2010 | Trade | Kam Mickolio | Baltimore Orioles | Arizona Diamondbacks | Trade |
| Dec 6, 2010 | Trade | Adrian Gonzalez | San Diego Padres | Boston Red Sox | Trade |
| Dec 6, 2010 | Trade | Casey Kelly | Boston Red Sox | San Diego Padres | Trade |
| Dec 6, 2010 | Trade | Anthony Rizzo | Boston Red Sox | San Diego Padres | Trade |
| Dec 6, 2010 | Trade | Rey Fuentes | Boston Red Sox | San Diego Padres | Trade |
| Dec 6, 2010 | Trade | Shaun Marcum | Toronto Blue Jays | Milwaukee Brewers | Trade |
| Dec 6, 2010 | Trade | Brett Lawrie | Milwaukee Brewers | Toronto Blue Jays | Trade |
| Dec 6, 2010 | Signed as free agent | Aaron Harang | — | San Diego Padres | Free agent signing |
| Dec 6, 2010 | Signed as free agent | Brian Bass | — | Philadelphia Phillies | Free agent signing |
| Dec 6, 2010 | Signed | Ramon Urias | — | Texas Rangers | Amateur free agent signing |
| Dec 5, 2010 | Signed as free agent | Wily Mo Peña | — | Arizona Diamondbacks | Free agent signing |
| Dec 5, 2010 | Signed as free agent | Jayson Werth | — | Washington Nationals | Free agent signing |
| Dec 5, 2010 | Signed as free agent | Donny Lucy | — | Chicago White Sox | Free agent signing |
| Dec 5, 2010 | Signed as free agent | Brad Snyder | — | Chicago Cubs | Free agent signing |
| Dec 5, 2010 | Signed as free agent | Jailen Peguero | — | Houston Astros | Free agent signing |
| Dec 5, 2010 | Signed as free agent | Sam Narron | — | Milwaukee Brewers | Free agent signing |
| Dec 5, 2010 | Signed as free agent | Shane Loux | — | San Francisco Giants | Free agent signing |
| Dec 4, 2010 | Signed as free agent | Lance Berkman | — | St. Louis Cardinals | Free agent signing |
| Dec 4, 2010 | Signed as free agent | Jack Hannahan | — | Cleveland Indians | Free agent signing |
| Dec 3, 2010 | Signed as free agent | Rod Barajas | — | Los Angeles Dodgers | Free agent signing |
| Dec 3, 2010 | Signed as free agent | Jason Bergmann | — | Boston Red Sox | Free agent signing |
| Dec 3, 2010 | Signed as free agent | Waldis Joaquin | — | San Francisco Giants | Free agent signing |
| Dec 3, 2010 | Signed as free agent | Luis Perdomo | — | San Diego Padres | Free agent signing |
| Dec 3, 2010 | Signed as free agent | Gregorio Petit | — | San Diego Padres | Free agent signing |
| Dec 3, 2010 | Signed as free agent | A. J. Pierzynski | — | Chicago White Sox | Free agent signing |
| Dec 3, 2010 | Trade | Unnamed | Chicago White Sox | Atlanta Braves | $ |
| Dec 3, 2010 | Trade | Scott Linebrink | Chicago White Sox | Atlanta Braves | Trade |
| Dec 3, 2010 | Trade | Kyle Cofield | Atlanta Braves | Chicago White Sox | Trade |
| Dec 3, 2010 | Signed as free agent | Drew Sutton | — | Boston Red Sox | Free agent signing |
| Dec 3, 2010 | Signed as free agent | Brandon Duckworth | — | Boston Red Sox | Free agent signing |
| Dec 3, 2010 | Signed as free agent | Adam Dunn | — | Chicago White Sox | Free agent signing |
| Dec 3, 2010 | Signed as free agent | Pat Burrell | — | San Francisco Giants | Free agent signing |
| Dec 3, 2010 | Signed as free agent | Jorge De La Rosa | — | Colorado Rockies | Free agent signing |
| Dec 2, 2010 | Signed as free agent | Erik Bedard | — | Seattle Mariners | Free agent signing |
| Dec 2, 2010 | Signed as free agent | Buddy Carlyle | — | New York Yankees | Free agent signing |
| Dec 2, 2010 | Signed as free agent | Eric Hinske | — | Atlanta Braves | Free agent signing |
| Dec 2, 2010 | Signed as free agent | R. J. Swindle | — | Tampa Bay Rays | Free agent signing |
| Dec 2, 2010 | Signed as free agent | Hisanori Takahashi | — | Los Angeles Angels of Anaheim | Free agent signing |
| Dec 2, 2010 | Signed as free agent | Javier Vazquez | — | Florida Marlins | Free agent signing |
| Dec 2, 2010 | Trade | Jose Lopez | Seattle Mariners | Colorado Rockies | Trade |
| Dec 2, 2010 | Trade | Chaz Roe | Colorado Rockies | Seattle Mariners | Trade |
| Dec 2, 2010 | Signed as free agent | Miguel Tejada | — | San Francisco Giants | Free agent signing |
| Dec 2, 2010 | Signed as free agent | Ruben Gotay | — | Florida Marlins | Free agent signing |
| Dec 1, 2010 | Signed as free agent | Andy Marte | — | Pittsburgh Pirates | Free agent signing |
| Dec 1, 2010 | Signed as free agent | Fernando Nieve | — | Pittsburgh Pirates | Free agent signing |
| Dec 1, 2010 | Signed as free agent | Dusty Brown | — | Pittsburgh Pirates | Free agent signing |
| Dec 1, 2010 | Signed as free agent | John Bale | — | Detroit Tigers | Free agent signing |
| Dec 1, 2010 | Signed | Andres Machado | — | Kansas City Royals | Amateur free agent signing |
| Nov 30, 2010 | Signed as free agent | Frank Francisco | — | Texas Rangers | Free agent signing |
| Nov 30, 2010 | Signed as free agent | Jason Frasor | — | Toronto Blue Jays | Free agent signing |
| Nov 30, 2010 | Signed as free agent | Brian Tallet | — | St. Louis Cardinals | Free agent signing |
| Nov 30, 2010 | Signed as free agent | Juan Uribe | — | Los Angeles Dodgers | Free agent signing |
| Nov 30, 2010 | Trade | Blake Hawksworth | St. Louis Cardinals | Los Angeles Dodgers | Trade |
| Nov 30, 2010 | Trade | Ryan Theriot | Los Angeles Dodgers | St. Louis Cardinals | Trade |
| Nov 30, 2010 | Signed as free agent | Yoshinori Tateyama | — | Texas Rangers | Free agent signing with first major-league team |
| Nov 29, 2010 | Signed as free agent | Brian Bruney | — | Chicago White Sox | Free agent signing |
| Nov 29, 2010 | Signed as free agent | Jeff Gray | — | Chicago White Sox | Free agent signing |
| Nov 29, 2010 | Signed as free agent | Matt Pagnozzi | — | Colorado Rockies | Free agent signing |
| Nov 29, 2010 | Signed as free agent | Eric Stults | — | Colorado Rockies | Free agent signing |
| Nov 29, 2010 | Signed as free agent | Scott Thorman | — | Detroit Tigers | Free agent signing |
| Nov 29, 2010 | Signed as free agent | Yorvit Torrealba | — | Texas Rangers | Free agent signing |
| Nov 29, 2010 | Signed as free agent | Luke Carlin | — | Cleveland Indians | Free agent signing |
| Nov 29, 2010 | Signed as free agent | Eddie Rogers | — | Arizona Diamondbacks | Free agent signing |
| Nov 29, 2010 | Signed as free agent | Josh Rupe | — | Baltimore Orioles | Free agent signing |
| Nov 29, 2010 | Signed as free agent | Daryle Ward | — | Chicago White Sox | Free agent signing |
| Nov 29, 2010 | Signed as free agent | Kyle Phillips | — | San Diego Padres | Free agent signing |
| Nov 29, 2010 | Signed as free agent | Winston Abreu | — | Toronto Blue Jays | Free agent signing |
| Nov 29, 2010 | Signed as free agent | Jimmy Barthmaier | — | Washington Nationals | Free agent signing |
| Nov 29, 2010 | Signed | Raimel Tapia | — | Colorado Rockies | Amateur free agent signing |
| Nov 27, 2010 | Signed as free agent | Brian Anderson | — | New York Yankees | Free agent signing |
| Nov 27, 2010 | Signed as free agent | Andy Sisco | — | New York Yankees | Free agent signing |
| Nov 26, 2010 | Signed as free agent | Jon Garland | — | Los Angeles Dodgers | Free agent signing |
| Nov 26, 2010 | Signed as free agent | Victor Martinez | — | Detroit Tigers | Free agent signing |
| Nov 24, 2010 | Signed as free agent | Brandon Boggs | — | Milwaukee Brewers | Free agent signing |
| Nov 24, 2010 | Released | Bryan Bullington | Kansas City Royals | — | Release |
| Nov 24, 2010 | Trade | Zach Duke | Pittsburgh Pirates | Arizona Diamondbacks | Trade |
| Nov 24, 2010 | Signed as free agent | Fabio Castro | — | Seattle Mariners | Free agent signing |
| Nov 24, 2010 | Signed as free agent | Luis Rodriguez | — | Seattle Mariners | Free agent signing |
| Nov 24, 2010 | Signed as free agent | Chris Smith | — | Seattle Mariners | Free agent signing |
| Nov 24, 2010 | Signed as free agent | Charlie Haeger | — | Seattle Mariners | Free agent signing |
| Nov 23, 2010 | Signed as free agent | Aubrey Huff | — | San Francisco Giants | Free agent signing |
| Nov 23, 2010 | Signed as free agent | Dontrelle Willis | — | Cincinnati Reds | Free agent signing |
| Nov 23, 2010 | Signed as free agent | Chris Seddon | — | Seattle Mariners | Free agent signing |
| Nov 23, 2010 | Signed as free agent | Oscar Villarreal | — | Los Angeles Dodgers | Free agent signing |
| Nov 22, 2010 | Signed as free agent | Zack Segovia | — | Milwaukee Brewers | Free agent signing |
| Nov 22, 2010 | Signed as free agent | Bobby Scales | — | Chicago Cubs | Free agent signing |
| Nov 22, 2010 | Signed as free agent | Wilkin Castillo | — | Atlanta Braves | Free agent signing |
| Nov 22, 2010 | Signed as free agent | Josh Kroeger | — | Florida Marlins | Free agent signing |
| Nov 22, 2010 | Signed as free agent | Dana Eveland | — | Los Angeles Dodgers | Free agent signing |
| Nov 20, 2010 | Signed as free agent | Chad Reineke | — | Cincinnati Reds | Free agent signing |
| Nov 20, 2010 | Signed as free agent | Enrique Gonzalez | — | Detroit Tigers | Free agent signing |
| Nov 20, 2010 | Signed as free agent | Jesus Guzman | — | San Diego Padres | Free agent signing |
| Nov 20, 2010 | Signed as free agent | Vinny Rottino | — | Florida Marlins | Free agent signing |
| Nov 20, 2010 | Signed as free agent | Jon Huber | — | Los Angeles Dodgers | Free agent signing |
| Nov 20, 2010 | Signed as free agent | Scott Patterson | — | Seattle Mariners | Free agent signing |
| Nov 20, 2010 | Released | Nathan Haynes | Texas Rangers | — | Release |
| Nov 20, 2010 | Signed as free agent | Victor Garate | — | Florida Marlins | Free agent signing |
| Nov 20, 2010 | Signed as free agent | Frank Mata | — | Florida Marlins | Free agent signing |
| Nov 20, 2010 | Signed | Miguel Almonte | — | Kansas City Royals | Amateur free agent signing |
| Nov 20, 2010 | Signed | Luis Perdomo | — | St. Louis Cardinals | Amateur free agent signing |
| Nov 19, 2010 | Released | Jonathan Albaladejo | New York Yankees | — | Release |
| Nov 19, 2010 | Signed as free agent | Al Alburquerque | — | Detroit Tigers | Free agent signing |
| Nov 19, 2010 | Signed as free agent | Joaquin Benoit | — | Detroit Tigers | Free agent signing |
| Nov 19, 2010 | Signed as free agent | Sean Burroughs | — | Arizona Diamondbacks | Free agent signing |
| Nov 19, 2010 | Signed as free agent | Russ Canzler | — | Tampa Bay Rays | Free agent signing |
| Nov 19, 2010 | Signed as free agent | Jose Constanza | — | Atlanta Braves | Free agent signing |
| Nov 19, 2010 | Signed as free agent | Neal Cotts | — | New York Yankees | Free agent signing |
| Nov 19, 2010 | Signed as free agent | Ryan Feierabend | — | Philadelphia Phillies | Free agent signing |
| Nov 19, 2010 | Signed as free agent | Brandon Moss | — | Philadelphia Phillies | Free agent signing |
| Nov 19, 2010 | Signed as free agent | Juan Perez | — | Philadelphia Phillies | Free agent signing |
| Nov 19, 2010 | Signed as free agent | Jay Sborz | — | Atlanta Braves | Free agent signing |
| Nov 19, 2010 | Signed as free agent | Raul Valdes | — | St. Louis Cardinals | Free agent signing |
| Nov 19, 2010 | Signed as free agent | Josh Barfield | — | Philadelphia Phillies | Free agent signing |
| Nov 19, 2010 | Signed as free agent | Justin Huber | — | Minnesota Twins | Free agent signing |
| Nov 19, 2010 | Signed as free agent | Ed Lucas | — | Atlanta Braves | Free agent signing |
| Nov 18, 2010 | Signed as free agent | Bryan LaHair | — | Chicago Cubs | Free agent signing |
| Nov 18, 2010 | Trade | Clint Barmes | Colorado Rockies | Houston Astros | Trade |
| Nov 18, 2010 | Trade | Felipe Paulino | Houston Astros | Colorado Rockies | Trade |
| Nov 18, 2010 | Trade | Scottie Allen | Arizona Diamondbacks | New York Yankees | Trade |
| Nov 18, 2010 | Trade | Juan Miranda | New York Yankees | Arizona Diamondbacks | Trade |
| Nov 18, 2010 | Signed as free agent | Jeff Larish | — | Philadelphia Phillies | Free agent signing |
| Nov 17, 2010 | Signed as free agent | John Buck | — | Florida Marlins | Free agent signing |
| Nov 17, 2010 | Signed as free agent | Phil Dumatrait | — | Minnesota Twins | Free agent signing |
| Nov 17, 2010 | Released | Micah Hoffpauir | Chicago Cubs | — | Release |
| Nov 17, 2010 | Signed as free agent | Dan Meyer | — | Philadelphia Phillies | Free agent signing |
| Nov 17, 2010 | Trade | Rajai Davis | Oakland Athletics | Toronto Blue Jays | Trade |
| Nov 17, 2010 | Trade | Danny Farquhar | Toronto Blue Jays | Oakland Athletics | Trade |
| Nov 17, 2010 | Trade | Trystan Magnuson | Toronto Blue Jays | Oakland Athletics | Trade |
| Nov 17, 2010 | Signed as free agent | Jeff Bailey | — | Minnesota Twins | Free agent signing |
| Nov 17, 2010 | Signed as free agent | Justin Miller | — | Seattle Mariners | Free agent signing |
| Nov 17, 2010 | Signed as free agent | Sean Kazmar | — | Seattle Mariners | Free agent signing |
| Nov 17, 2010 | Signed as free agent | Jai Miller | — | Oakland Athletics | Free agent signing |
| Nov 17, 2010 | Signed as free agent | Dallas McPherson | — | Chicago White Sox | Free agent signing |
| Nov 17, 2010 | Signed as free agent | Scott Rice | — | Chicago Cubs | Free agent signing |
| Nov 16, 2010 | Signed as free agent | Brett Carroll | — | Kansas City Royals | Free agent signing |
| Nov 16, 2010 | Released | Manny Corpas | Colorado Rockies | — | Release |
| Nov 16, 2010 | Signed as free agent | Jeff Frazier | — | Washington Nationals | Free agent signing |
| Nov 16, 2010 | Signed as free agent | Anthony Lerew | — | Oakland Athletics | Free agent signing |
| Nov 16, 2010 | Signed as free agent | Scott Moore | — | Chicago Cubs | Free agent signing |
| Nov 16, 2010 | Signed as free agent | Jake Westbrook | — | St. Louis Cardinals | Free agent signing |
| Nov 16, 2010 | Signed as free agent | Mike Wilson | — | Seattle Mariners | Free agent signing |
| Nov 16, 2010 | Trade | Dan Uggla | Florida Marlins | Atlanta Braves | Trade |
| Nov 16, 2010 | Trade | Omar Infante | Atlanta Braves | Florida Marlins | Trade |
| Nov 16, 2010 | Trade | Mike Dunn | Atlanta Braves | Florida Marlins | Trade |
| Nov 16, 2010 | Signed as free agent | Esteban German | — | Texas Rangers | Free agent signing |
| Nov 16, 2010 | Signed | Erick Castillo | — | Chicago Cubs | Amateur free agent signing |
| Nov 15, 2010 | Signed as free agent | Mitch Atkins | — | Baltimore Orioles | Free agent signing |
| Nov 15, 2010 | Signed as free agent | Geoff Blum | — | Arizona Diamondbacks | Free agent signing |
| Nov 15, 2010 | Signed as free agent | Jose Contreras | — | Philadelphia Phillies | Free agent signing |
| Nov 15, 2010 | Signed as free agent | Ramon Hernandez | — | Cincinnati Reds | Free agent signing |
| Nov 15, 2010 | Released | Shawn Hill | Toronto Blue Jays | — | Release |
| Nov 15, 2010 | Signed as free agent | Hiroki Kuroda | — | Los Angeles Dodgers | Free agent signing |
| Nov 15, 2010 | Signed as free agent | Anthony Reyes | — | Cleveland Indians | Free agent signing |
| Nov 15, 2010 | Trade | Anthony Jackson | Colorado Rockies | Los Angeles Dodgers | Trade |
| Nov 15, 2010 | Signed as free agent | Steven Shell | — | Kansas City Royals | Free agent signing |
| Nov 13, 2010 | Trade | Cameron Maybin | Florida Marlins | San Diego Padres | Trade |
| Nov 13, 2010 | Trade | Edward Mujica | San Diego Padres | Florida Marlins | Trade |
| Nov 13, 2010 | Trade | Ryan Webb | San Diego Padres | Florida Marlins | Trade |
| Nov 12, 2010 | Signed as free agent | Tim Wood | — | Washington Nationals | Free agent signing |
| Nov 12, 2010 | Trade | Andrew Miller | Florida Marlins | Boston Red Sox | Trade |
| Nov 12, 2010 | Trade | Dustin Richardson | Boston Red Sox | Florida Marlins | Trade |
| Nov 12, 2010 | Signed as free agent | Eddie Bonine | — | Philadelphia Phillies | Free agent signing |
| Nov 12, 2010 | Signed as free agent | Erik Kratz | — | Philadelphia Phillies | Free agent signing |
| Nov 12, 2010 | Signed as free agent | Mark McLemore | — | Florida Marlins | Free agent signing |
| Nov 11, 2010 | Signed as free agent | Yorman Bazardo | — | Minnesota Twins | Free agent signing |
| Nov 11, 2010 | Signed as free agent | Mike O'Connor | — | New York Mets | Free agent signing |
| Nov 11, 2010 | Signed as free agent | Kevin Cash | — | Texas Rangers | Free agent signing |
| Nov 11, 2010 | Signed as free agent | Carlos Corporan | — | Houston Astros | Free agent signing |
| Nov 11, 2010 | Signed as free agent | Hector Gimenez | — | Los Angeles Dodgers | Free agent signing |
| Nov 11, 2010 | Signed as free agent | Yusmeiro Petit | — | Seattle Mariners | Free agent signing |
| Nov 11, 2010 | Signed as free agent | Willie Collazo | — | Toronto Blue Jays | Free agent signing |
| Nov 11, 2010 | Signed as free agent | Mike Hinckley | — | Toronto Blue Jays | Free agent signing |
| Nov 10, 2010 | Signed as free agent | Fernando Rodriguez | — | Houston Astros | Free agent signing |
| Nov 10, 2010 | Signed as free agent | Cory Wade | — | Tampa Bay Rays | Free agent signing |
| Nov 10, 2010 | Trade | Vin Mazzaro | Oakland Athletics | Kansas City Royals | Trade |
| Nov 10, 2010 | Trade | Justin Marks | Oakland Athletics | Kansas City Royals | Trade |
| Nov 10, 2010 | Trade | David DeJesus | Kansas City Royals | Oakland Athletics | Trade |
| Nov 10, 2010 | Signed as free agent | Corky Miller | — | Cincinnati Reds | Free agent signing |
| Nov 10, 2010 | Signed as free agent | Pete Orr | — | Philadelphia Phillies | Free agent signing |
| Nov 10, 2010 | Released | Phillips Valdez | Cleveland Indians | — | Release |
| Nov 9, 2010 | Signed as free agent | Eric Hacker | — | Minnesota Twins | Free agent signing |
| Nov 9, 2010 | Signed as free agent | Rich Thompson | — | Philadelphia Phillies | Free agent signing |
| Nov 9, 2010 | Signed as free agent | Ross Wolf | — | Houston Astros | Free agent signing |
| Nov 8, 2010 | Signed as free agent | Darin Downs | — | Florida Marlins | Free agent signing |
| Nov 8, 2010 | Signed as free agent | Jhonny Peralta | — | Detroit Tigers | Free agent signing |
| Nov 8, 2010 | Signed as free agent | Max St. Pierre | — | Detroit Tigers | Free agent signing |
| Nov 8, 2010 | Signed as free agent | Justin Thomas | — | Pittsburgh Pirates | Free agent signing |
| Nov 8, 2010 | Signed as free agent | Brent Clevlen | — | Atlanta Braves | Free agent signing |
| Nov 8, 2010 | Signed as free agent | Mike Parisi | — | Chicago Cubs | Free agent signing |
| Nov 7, 2010 | Signed as free agent | Anderson Hernandez | — | Houston Astros | Free agent signing |
| Nov 7, 2010 | Signed as free agent | Guilder Rodriguez | — | Texas Rangers | Free agent signing |
| Nov 5, 2010 | Signed as free agent | Willie Eyre | — | Oakland Athletics | Free agent signing |
| Nov 5, 2010 | Signed as free agent | Casey Fien | — | Houston Astros | Free agent signing |
| Nov 5, 2010 | Signed as free agent | Angel Guzman | — | Chicago Cubs | Free agent signing |
| Nov 5, 2010 | Released | Tyler Walker | Washington Nationals | — | Release |
| Nov 5, 2010 | Released | Hisanori Takahashi | New York Mets | — | Release |
| Nov 4, 2010 | Trade | Brent Dlugach | Detroit Tigers | Boston Red Sox | Trade |
| Nov 4, 2010 | Signed as free agent | Jay Gibbons | — | Los Angeles Dodgers | Free agent signing |
| Nov 4, 2010 | Released | Chris Jakubauskas | Pittsburgh Pirates | — | Release |
| Nov 4, 2010 | Signed | Luis Marte | — | Texas Rangers | Amateur free agent signing |
| Nov 2, 2010 | Signed as free agent | Omar Vizquel | — | Chicago White Sox | Free agent signing |
| Oct 29, 2010 | Signed as free agent | Justin Lehr | — | Cincinnati Reds | Free agent signing |
| Oct 26, 2010 | Released | Carlos Torres | Chicago White Sox | — | Release |
| Oct 26, 2010 | Signed as free agent | Sean Henn | — | Toronto Blue Jays | Free agent signing |
| Oct 25, 2010 | Signed as free agent | Brian Esposito | — | Houston Astros | Free agent signing |
| Oct 22, 2010 | Signed | Orlando Arcia | — | Milwaukee Brewers | Amateur free agent signing |
| Oct 21, 2010 | Trade | Andrew Shive | New York Yankees | Cleveland Indians | Trade |
| Oct 21, 2010 | Trade | Matt Cusick | New York Yankees | Cleveland Indians | Trade |
| Oct 20, 2010 | Signed as free agent | Erik Hamren | — | San Diego Padres | Free agent signing |
| Oct 18, 2010 | Released | Melky Cabrera | Atlanta Braves | — | Release |
| Oct 18, 2010 | Signed as free agent | Donnie Murphy | — | Florida Marlins | Free agent signing |
| Oct 18, 2010 | Released | Takashi Saito | Atlanta Braves | — | Release |
| Oct 18, 2010 | Signed | Andrew Werner | — | San Diego Padres | Amateur free agent signing |
| Oct 14, 2010 | Signed as free agent | Mike Rivera | — | Milwaukee Brewers | Free agent signing |
| Oct 14, 2010 | Trade | Kevin Pucetas | San Francisco Giants | Kansas City Royals | Trade |
| Oct 10, 2010 | Signed | Yonathan Daza | — | Colorado Rockies | Amateur free agent signing |
| Oct 8, 2010 | Released | Rich Harden | Texas Rangers | — | Release |
| Oct 8, 2010 | Released | Matt Herges | Kansas City Royals | — | Release |
| Oct 5, 2010 | Released | Jon Edwards | St. Louis Cardinals | — | Release |
| Oct 5, 2010 | Signed | Ronny Rodriguez | — | Cleveland Indians | Amateur free agent signing |
| Oct 4, 2010 | Released | Akinori Iwamura | Oakland Athletics | — | Release |
| Oct 2, 2010 | Signed | Jeimer Candelario | — | Chicago Cubs | Amateur free agent signing |
| Sep 28, 2010 | Signed | David Paulino | — | Detroit Tigers | Amateur free agent signing |
| Sep 25, 2010 | Signed as free agent | Felipe Lopez | — | Boston Red Sox | Free agent signing |
| Sep 21, 2010 | Released | Felipe Lopez | St. Louis Cardinals | — | Release |
| Sep 21, 2010 | Signed | Thyago Vieira | — | Seattle Mariners | Amateur free agent signing |
| Sep 18, 2010 | Trade | Octavio Dotel | Los Angeles Dodgers | Colorado Rockies | Trade |
| Sep 17, 2010 | Released | Neal Cotts | Pittsburgh Pirates | — | Release |
| Sep 16, 2010 | Signed | Reyes Moronta | — | San Francisco Giants | Amateur free agent signing |
| Sep 13, 2010 | Signed as free agent | Akinori Iwamura | — | Oakland Athletics | Free agent signing |
| Sep 10, 2010 | Released | Akinori Iwamura | Pittsburgh Pirates | — | Release |
| Sep 10, 2010 | Released | Nate Robertson | Philadelphia Phillies | — | Release |
| Sep 9, 2010 | Released | Ronnie Belliard | Los Angeles Dodgers | — | Release |
| Sep 9, 2010 | Trade | Matt Gorgen | Tampa Bay Rays | Arizona Diamondbacks | Trade |
| Sep 7, 2010 | Released | Alex Cora | Texas Rangers | — | Release |
| Sep 7, 2010 | Released | Robb Quinlan | Los Angeles Angels of Anaheim | — | Release |
| Sep 7, 2010 | Released | Brian Stokes | Los Angeles Angels of Anaheim | — | Release |
| Sep 4, 2010 | Signed as free agent | Mark Prior | — | Texas Rangers | Free agent signing |
| Sep 3, 2010 | Signed as free agent | Jeremy Hermida | — | Oakland Athletics | Free agent signing |
| Sep 2, 2010 | Signed as free agent | Mike Rivera | — | Florida Marlins | Free agent signing |
| Sep 1, 2010 | Trade | Loek van Mil | Minnesota Twins | Los Angeles Angels of Anaheim | Trade |
| Aug 31, 2010 | Signed as free agent | Tommy Everidge | — | Oakland Athletics | Free agent signing |
| Aug 31, 2010 | Released | Jeremy Hermida | Boston Red Sox | — | Release |
| Aug 31, 2010 | Trade | Unnamed | New York Mets | Texas Rangers | $ |
| Aug 31, 2010 | Trade | Jeff Francoeur | New York Mets | Texas Rangers | Trade |
| Aug 31, 2010 | Trade | Joaquin Arias | Texas Rangers | New York Mets | Trade |
| Aug 31, 2010 | Trade | Unnamed | Boston Red Sox | Colorado Rockies | $ |
| Aug 31, 2010 | Trade | Manny Delcarmen | Boston Red Sox | Colorado Rockies | Trade |
| Aug 31, 2010 | Trade | Chris Balcom-Miller | Colorado Rockies | Boston Red Sox | Trade |
| Aug 28, 2010 | Released | Mike Rivera | Los Angeles Dodgers | — | Release |
| Aug 28, 2010 | Signed | Orlando Calixte | — | Kansas City Royals | Amateur free agent signing |
| Aug 27, 2010 | Signed as free agent | Luis Ayala | — | Colorado Rockies | Free agent signing |
| Aug 27, 2010 | Signed as free agent | Brad Hawpe | — | Tampa Bay Rays | Free agent signing |
| Aug 27, 2010 | Trade | Brian Fuentes | Los Angeles Angels of Anaheim | Minnesota Twins | Trade |
| Aug 26, 2010 | Released | Brad Hawpe | Colorado Rockies | — | Release |
| Aug 26, 2010 | Signed as free agent | Chris Aguila | — | Florida Marlins | Free agent signing |
| Aug 24, 2010 | Released | Bobby Crosby | Arizona Diamondbacks | — | Release |
| Aug 24, 2010 | Signed as free agent | Nate Robertson | — | Philadelphia Phillies | Free agent signing |
| Aug 24, 2010 | Signed | Miguel Del Pozo | — | Miami Marlins | Amateur free agent signing |
| Aug 23, 2010 | Released | David Riske | Milwaukee Brewers | — | Release |
| Aug 21, 2010 | Released | Chris Aguila | Philadelphia Phillies | — | Release |
| Aug 21, 2010 | Signed as free agent | Mike Hampton | — | Arizona Diamondbacks | Free agent signing |
| Aug 21, 2010 | Released | Renyel Pinto | St. Louis Cardinals | — | Release |
| Aug 21, 2010 | Signed as free agent | Saul Rivera | — | Cleveland Indians | Free agent signing |
| Aug 20, 2010 | Trade | Zach McAllister | New York Yankees | Cleveland Indians | Trade |
| Aug 20, 2010 | Signed as free agent | Jody Gerut | — | San Diego Padres | Free agent signing |
| Aug 20, 2010 | Signed as free agent | Edgar Gonzalez | — | Los Angeles Dodgers | Free agent signing |
| Aug 20, 2010 | Released | Brandon Mann | Los Angeles Dodgers | — | Release |
| Aug 19, 2010 | Released | Andrew Brown | St. Louis Cardinals | — | Release |
| Aug 19, 2010 | Trade | Unnamed | Houston Astros | St. Louis Cardinals | $ |
| Aug 19, 2010 | Trade | Pedro Feliz | Houston Astros | St. Louis Cardinals | Trade |
| Aug 19, 2010 | Trade | David Carpenter | St. Louis Cardinals | Houston Astros | Trade |
| Aug 18, 2010 | Signed as free agent | Ramon Ortiz | — | Tampa Bay Rays | Free agent signing |
| Aug 18, 2010 | Trade | Derrek Lee | Chicago Cubs | Atlanta Braves | Trade |
| Aug 18, 2010 | Trade | Jeff Lorick | Atlanta Braves | Chicago Cubs | Trade |
| Aug 18, 2010 | Trade | Robinson Lopez | Atlanta Braves | Chicago Cubs | Trade |
| Aug 18, 2010 | Trade | Ty'Relle Harris | Atlanta Braves | Chicago Cubs | Trade |
| Aug 17, 2010 | Signed as free agent | Alex Cora | — | Texas Rangers | Free agent signing |
| Aug 17, 2010 | Released | Todd Wellemeyer | San Francisco Giants | — | Release |
| Aug 16, 2010 | Signed as free agent | Bobby Livingston | — | Tampa Bay Rays | Free agent signing |
| Aug 16, 2010 | Released | Claudio Vargas | Los Angeles Dodgers | — | Release |
| Aug 16, 2010 | Signed | Randy Rosario | — | Minnesota Twins | Amateur free agent signing |
| Aug 15, 2010 | Signed as free agent | Willy Taveras | — | Texas Rangers | Free agent signing |
| Aug 15, 2010 | Signed as free agent | Tug Hulett | — | Seattle Mariners | Free agent signing |
| Aug 15, 2010 | Signed as free agent | Jesus Colome | — | Texas Rangers | Free agent signing |
| Aug 15, 2010 | Signed as free agent | Yhency Brazoban | — | New York Mets | Free agent signing |
| Aug 14, 2010 | Released | Ryan Shealy | Boston Red Sox | — | Release |
| Aug 14, 2010 | Trade | Michael Thomas | Boston Red Sox | Texas Rangers | Trade |
| Aug 13, 2010 | Released | Jody Gerut | Milwaukee Brewers | — | Release |
| Aug 13, 2010 | Trade | Unnamed | San Francisco Giants | Kansas City Royals | $ |
| Aug 13, 2010 | Trade | Jose Guillen | Kansas City Royals | San Francisco Giants | Trade |
| Aug 13, 2010 | Signed | Ketel Marte | — | Seattle Mariners | Amateur free agent signing |
| Aug 13, 2010 | Signed | Jarlin Garcia | — | Florida Marlins | Amateur free agent signing |
| Aug 12, 2010 | Released | Ron Villone | Washington Nationals | — | Release |
| Aug 11, 2010 | Trade | Mike Fontenot | Chicago Cubs | San Francisco Giants | Trade |
| Aug 11, 2010 | Trade | Evan Crawford | San Francisco Giants | Chicago Cubs | Trade |
| Aug 10, 2010 | Released | Garret Anderson | Los Angeles Dodgers | — | Release |
| Aug 9, 2010 | Signed as free agent | Geoff Geary | — | Los Angeles Dodgers | Free agent signing |
| Aug 9, 2010 | Trade | Jim Edmonds | Milwaukee Brewers | Cincinnati Reds | Trade |
| Aug 9, 2010 | Trade | Chris Dickerson | Cincinnati Reds | Milwaukee Brewers | Trade |
| Aug 8, 2010 | Released | Bobby Livingston | Los Angeles Dodgers | — | Release |
| Aug 8, 2010 | Signed as free agent | Michael Restovich | — | Los Angeles Dodgers | Free agent signing |
| Aug 7, 2010 | Released | Alex Cora | New York Mets | — | Release |
| Aug 7, 2010 | Trade | Tyler Skaggs | Los Angeles Angels of Anaheim | Arizona Diamondbacks | Trade |
| Aug 7, 2010 | Signed as free agent | Carlos Delgado | — | Boston Red Sox | Free agent signing |
| Aug 7, 2010 | Released | Tug Hulett | Boston Red Sox | — | Release |
| Aug 6, 2010 | Released | Michael Restovich | Los Angeles Dodgers | — | Release |
| Aug 6, 2010 | Released | Mike Rabelo | Detroit Tigers | — | Release |
| Aug 6, 2010 | Released | Luis Maza | Houston Astros | — | Release |
| Aug 5, 2010 | Released | Brad Hennessey | Minnesota Twins | — | Release |
| Aug 5, 2010 | Released | Tim Redding | New York Yankees | — | Release |
| Aug 5, 2010 | Signed as free agent | Chad Tracy | — | Florida Marlins | Free agent signing |
| Aug 4, 2010 | Released | Josh Anderson | Atlanta Braves | — | Release |
| Aug 2, 2010 | Signed as free agent | Mike Koplove | — | San Diego Padres | Free agent signing |
| Aug 2, 2010 | Signed as free agent | Nate Robertson | — | St. Louis Cardinals | Free agent signing |
| Aug 2, 2010 | Released | Willy Taveras | Atlanta Braves | — | Release |
| Aug 1, 2010 | Released | Ramon Ortiz | New York Mets | — | Release |
| Aug 1, 2010 | Signed as free agent | Bobby Livingston | — | Los Angeles Dodgers | Free agent signing |
| Jul 31, 2010 | Released | Chris Duffy | Philadelphia Phillies | — | Release |
| Jul 31, 2010 | Signed | Yunesky Maya | — | Washington Nationals | Amateur free agent signing |
| Jul 31, 2010 | Released | Brad Thompson | Houston Astros | — | Release |
| Jul 31, 2010 | Trade | Unnamed | Pittsburgh Pirates | Los Angeles Dodgers | $ |
| Jul 31, 2010 | Trade | Octavio Dotel | Pittsburgh Pirates | Los Angeles Dodgers | Trade |
| Jul 31, 2010 | Trade | James McDonald | Los Angeles Dodgers | Pittsburgh Pirates | Trade |
| Jul 31, 2010 | Trade | Andrew Lambo | Los Angeles Dodgers | Pittsburgh Pirates | Trade |
| Jul 31, 2010 | Trade | Unnamed | Cleveland Indians | New York Yankees | $ |
| Jul 31, 2010 | Trade | Kerry Wood | Cleveland Indians | New York Yankees | Trade |
| Jul 31, 2010 | Trade | Unnamed | Chicago Cubs | Los Angeles Dodgers | $ |
| Jul 31, 2010 | Trade | Ted Lilly | Chicago Cubs | Los Angeles Dodgers | Trade |
| Jul 31, 2010 | Trade | Ryan Theriot | Chicago Cubs | Los Angeles Dodgers | Trade |
| Jul 31, 2010 | Trade | Blake DeWitt | Los Angeles Dodgers | Chicago Cubs | Trade |
| Jul 31, 2010 | Trade | Brett Wallach | Los Angeles Dodgers | Chicago Cubs | Trade |
| Jul 31, 2010 | Trade | Kyle Smit | Los Angeles Dodgers | Chicago Cubs | Trade |
| Jul 31, 2010 | Trade | Unnamed | Boston Red Sox | Texas Rangers | $ |
| Jul 31, 2010 | Trade | Chris McGuiness | Boston Red Sox | Texas Rangers | Trade |
| Jul 31, 2010 | Trade | Roman Mendez | Boston Red Sox | Texas Rangers | Trade |
| Jul 31, 2010 | Trade | Jarrod Saltalamacchia | Texas Rangers | Boston Red Sox | Trade |
| Jul 31, 2010 | Trade | Unnamed | Arizona Diamondbacks | Pittsburgh Pirates | $ |
| Jul 31, 2010 | Trade | Pedro Ciriaco | Arizona Diamondbacks | Pittsburgh Pirates | Trade |
| Jul 31, 2010 | Trade | Chris Snyder | Arizona Diamondbacks | Pittsburgh Pirates | Trade |
| Jul 31, 2010 | Trade | D. J. Carrasco | Pittsburgh Pirates | Arizona Diamondbacks | Trade |
| Jul 31, 2010 | Trade | Bobby Crosby | Pittsburgh Pirates | Arizona Diamondbacks | Trade |
| Jul 31, 2010 | Trade | Ryan Church | Pittsburgh Pirates | Arizona Diamondbacks | Trade |
| Jul 31, 2010 | Trade | Ramon Ramirez | Boston Red Sox | San Francisco Giants | Trade |
| Jul 31, 2010 | Trade | Daniel Turpen | San Francisco Giants | Boston Red Sox | Trade |
| Jul 31, 2010 | Trade | Jake Westbrook | Cleveland Indians | St. Louis Cardinals | Trade |
| Jul 31, 2010 | Trade | Nick Greenwood | San Diego Padres | St. Louis Cardinals | Trade |
| Jul 31, 2010 | Trade | Ryan Ludwick | St. Louis Cardinals | San Diego Padres | Trade |
| Jul 31, 2010 | Trade | Corey Kluber | San Diego Padres | Cleveland Indians | Trade |
| Jul 31, 2010 | Trade | Will Ohman | Baltimore Orioles | Florida Marlins | Trade |
| Jul 31, 2010 | Trade | Rick van den Hurk | Florida Marlins | Baltimore Orioles | Trade |
| Jul 31, 2010 | Trade | Javier Lopez | Pittsburgh Pirates | San Francisco Giants | Trade |
| Jul 31, 2010 | Trade | John Bowker | San Francisco Giants | Pittsburgh Pirates | Trade |
| Jul 31, 2010 | Trade | Joe Martinez | San Francisco Giants | Pittsburgh Pirates | Trade |
| Jul 31, 2010 | Trade | Lance Berkman | Houston Astros | New York Yankees | Trade |
| Jul 31, 2010 | Trade | Mark Melancon | New York Yankees | Houston Astros | Trade |
| Jul 31, 2010 | Trade | Jimmy Paredes | New York Yankees | Houston Astros | Trade |
| Jul 31, 2010 | Trade | Rick Ankiel | Kansas City Royals | Atlanta Braves | Trade |
| Jul 31, 2010 | Trade | Kyle Farnsworth | Kansas City Royals | Atlanta Braves | Trade |
| Jul 31, 2010 | Trade | Gregor Blanco | Atlanta Braves | Kansas City Royals | Trade |
| Jul 31, 2010 | Trade | Jesse Chavez | Atlanta Braves | Kansas City Royals | Trade |
| Jul 31, 2010 | Trade | Tim Collins | Atlanta Braves | Kansas City Royals | Trade |
| Jul 31, 2010 | Trade | Chad Qualls | Arizona Diamondbacks | Tampa Bay Rays | Trade |
| Jul 30, 2010 | Released | Bob Howry | Chicago Cubs | — | Release |
| Jul 30, 2010 | Trade | Austin Kearns | Cleveland Indians | New York Yankees | Trade |
| Jul 30, 2010 | Trade | Cristian Guzman | Washington Nationals | Texas Rangers | Trade |
| Jul 30, 2010 | Trade | Ryan Tatusko | Texas Rangers | Washington Nationals | Trade |
| Jul 30, 2010 | Trade | Tanner Roark | Texas Rangers | Washington Nationals | Trade |
| Jul 30, 2010 | Trade | Edwin Jackson | Arizona Diamondbacks | Chicago White Sox | Trade |
| Jul 30, 2010 | Trade | Daniel Hudson | Chicago White Sox | Arizona Diamondbacks | Trade |
| Jul 30, 2010 | Trade | David Holmberg | Chicago White Sox | Arizona Diamondbacks | Trade |
| Jul 29, 2010 | Released | Brendan Donnelly | Pittsburgh Pirates | — | Release |
| Jul 29, 2010 | Released | Tommy Everidge | Houston Astros | — | Release |
| Jul 29, 2010 | Trade | Roy Oswalt | Houston Astros | Philadelphia Phillies | Trade |
| Jul 29, 2010 | Trade | J. A. Happ | Philadelphia Phillies | Houston Astros | Trade |
| Jul 29, 2010 | Trade | Anthony Gose | Philadelphia Phillies | Houston Astros | Trade |
| Jul 29, 2010 | Trade | Jonathan Villar | Philadelphia Phillies | Houston Astros | Trade |
| Jul 29, 2010 | Trade | Evan Reed | Texas Rangers | Florida Marlins | Trade |
| Jul 29, 2010 | Trade | Omar Poveda | Texas Rangers | Florida Marlins | Trade |
| Jul 29, 2010 | Trade | Jorge Cantu | Florida Marlins | Texas Rangers | Trade |
| Jul 29, 2010 | Trade | Wilson Ramos | Minnesota Twins | Washington Nationals | Trade |
| Jul 29, 2010 | Trade | Joe Testa | Minnesota Twins | Washington Nationals | Trade |
| Jul 29, 2010 | Trade | Matt Capps | Washington Nationals | Minnesota Twins | Trade |
| Jul 29, 2010 | Trade | Unnamed | Baltimore Orioles | San Diego Padres | $ |
| Jul 29, 2010 | Trade | Miguel Tejada | Baltimore Orioles | San Diego Padres | Trade |
| Jul 29, 2010 | Trade | Wynn Pelzer | San Diego Padres | Baltimore Orioles | Trade |
| Jul 29, 2010 | Trade | Brett Wallace | Toronto Blue Jays | Houston Astros | Trade |
| Jul 29, 2010 | Trade | Anthony Gose | Houston Astros | Toronto Blue Jays | Trade |
| Jul 29, 2010 | Signed | Dilson Herrera | — | Pittsburgh Pirates | Amateur free agent signing |
| Jul 28, 2010 | Signed as free agent | Jon Adkins | — | Chicago White Sox | Free agent signing |
| Jul 28, 2010 | Released | Alejandro Machado | Atlanta Braves | — | Release |
| Jul 28, 2010 | Trade | Unnamed | Cleveland Indians | Detroit Tigers | $ |
| Jul 28, 2010 | Trade | Jhonny Peralta | Cleveland Indians | Detroit Tigers | Trade |
| Jul 28, 2010 | Trade | Giovanni Soto | Detroit Tigers | Cleveland Indians | Trade |
| Jul 28, 2010 | Trade | Scott Podsednik | Kansas City Royals | Los Angeles Dodgers | Trade |
| Jul 28, 2010 | Trade | Lucas May | Los Angeles Dodgers | Kansas City Royals | Trade |
| Jul 28, 2010 | Trade | Elisaul Pimentel | Los Angeles Dodgers | Kansas City Royals | Trade |
| Jul 27, 2010 | Signed as free agent | Juan Castro | — | Los Angeles Dodgers | Free agent signing |
| Jul 27, 2010 | Released | Nate Robertson | Florida Marlins | — | Release |
| Jul 27, 2010 | Signed as free agent | Ryan Vogelsong | — | Los Angeles Angels of Anaheim | Free agent signing |
| Jul 27, 2010 | Released | Bobby Livingston | New York Mets | — | Release |
| Jul 27, 2010 | Signed as free agent | Travis Chick | — | Pittsburgh Pirates | Free agent signing |
| Jul 26, 2010 | Released | Saul Rivera | Arizona Diamondbacks | — | Release |
| Jul 26, 2010 | Released | Geoff Geary | Texas Rangers | — | Release |
| Jul 26, 2010 | Released | Joe Nelson | Seattle Mariners | — | Release |
| Jul 25, 2010 | Released | Billy Buckner | Detroit Tigers | — | Release |
| Jul 25, 2010 | Trade | Dan Haren | Arizona Diamondbacks | Los Angeles Angels of Anaheim | Trade |
| Jul 25, 2010 | Trade | Joe Saunders | Los Angeles Angels of Anaheim | Arizona Diamondbacks | Trade |
| Jul 25, 2010 | Trade | Rafael Rodriguez | Los Angeles Angels of Anaheim | Arizona Diamondbacks | Trade |
| Jul 25, 2010 | Trade | Patrick Corbin | Los Angeles Angels of Anaheim | Arizona Diamondbacks | Trade |
| Jul 24, 2010 | Signed as free agent | Nick Green | — | San Diego Padres | Free agent signing |
| Jul 23, 2010 | Released | Kason Gabbard | Boston Red Sox | — | Release |
| Jul 23, 2010 | Signed as free agent | Jason Lane | — | Toronto Blue Jays | Free agent signing |
| Jul 23, 2010 | Released | Hayden Penn | Pittsburgh Pirates | — | Release |
| Jul 22, 2010 | Released | Randor Bierd | Boston Red Sox | — | Release |
| Jul 22, 2010 | Released | Vinnie Chulk | Pittsburgh Pirates | — | Release |
| Jul 22, 2010 | Released | Joey Gathright | Baltimore Orioles | — | Release |
| Jul 22, 2010 | Trade | Alberto Callaspo | Kansas City Royals | Los Angeles Angels of Anaheim | Trade |
| Jul 22, 2010 | Trade | Sean O'Sullivan | Los Angeles Angels of Anaheim | Kansas City Royals | Trade |
| Jul 22, 2010 | Trade | Will Smith | Los Angeles Angels of Anaheim | Kansas City Royals | Trade |
| Jul 22, 2010 | Signed as free agent | Chad Cordero | — | New York Mets | Free agent signing |
| Jul 22, 2010 | Signed as free agent | Timo Perez | — | Philadelphia Phillies | Free agent signing |
| Jul 22, 2010 | Signed as free agent | Jason Isringhausen | — | Cincinnati Reds | Free agent signing |
| Jul 19, 2010 | Signed as free agent | Rocco Baldelli | — | Tampa Bay Rays | Free agent signing |
| Jul 19, 2010 | Released | Kiko Calero | Los Angeles Dodgers | — | Release |
| Jul 19, 2010 | Signed as free agent | Wily Mo Peña | — | San Diego Padres | Free agent signing |
| Jul 19, 2010 | Released | Ramon Vazquez | Houston Astros | — | Release |
| Jul 17, 2010 | Released | Juan Castro | Philadelphia Phillies | — | Release |
| Jul 16, 2010 | Released | Mike Redmond | Cleveland Indians | — | Release |
| Jul 15, 2010 | Signed as free agent | Russ Springer | — | Cincinnati Reds | Free agent signing |
| Jul 15, 2010 | Signed as free agent | Jamey Wright | — | Seattle Mariners | Free agent signing |
| Jul 15, 2010 | Released | Armando Benitez | Florida Marlins | — | Release |
| Jul 15, 2010 | Released | Ryan Vogelsong | Philadelphia Phillies | — | Release |
| Jul 15, 2010 | Released | Luis Ayala | Arizona Diamondbacks | — | Release |
| Jul 15, 2010 | Signed as free agent | Charlton Jimerson | — | Los Angeles Angels of Anaheim | Free agent signing |
| Jul 15, 2010 | Signed | Humberto Arteaga | — | Kansas City Royals | Amateur free agent signing |
| Jul 14, 2010 | Signed as free agent | Dontrelle Willis | — | San Francisco Giants | Free agent signing |
| Jul 14, 2010 | Released | Jamey Wright | Oakland Athletics | — | Release |
| Jul 14, 2010 | Trade | Alex Gonzalez | Toronto Blue Jays | Atlanta Braves | Trade |
| Jul 14, 2010 | Trade | Tim Collins | Toronto Blue Jays | Atlanta Braves | Trade |
| Jul 14, 2010 | Trade | Tyler Pastornicky | Toronto Blue Jays | Atlanta Braves | Trade |
| Jul 14, 2010 | Trade | Yunel Escobar | Atlanta Braves | Toronto Blue Jays | Trade |
| Jul 14, 2010 | Trade | Jo-Jo Reyes | Atlanta Braves | Toronto Blue Jays | Trade |
| Jul 14, 2010 | Released | Mark Worrell | Seattle Mariners | — | Release |
| Jul 13, 2010 | Signed as free agent | Jeremy Reed | — | Chicago White Sox | Free agent signing |
| Jul 13, 2010 | Released | Jon Adkins | Cincinnati Reds | — | Release |
| Jul 12, 2010 | Released | Billy Traber | Seattle Mariners | — | Release |
| Jul 12, 2010 | Signed | Angel Sanchez | — | Los Angeles Dodgers | Amateur free agent signing |
| Jul 9, 2010 | Signed as free agent | Chad Tracy | — | New York Yankees | Free agent signing |
| Jul 9, 2010 | Trade | Cliff Lee | Seattle Mariners | Texas Rangers | Trade |
| Jul 9, 2010 | Trade | Mark Lowe | Seattle Mariners | Texas Rangers | Trade |
| Jul 9, 2010 | Trade | Justin Smoak | Texas Rangers | Seattle Mariners | Trade |
| Jul 9, 2010 | Trade | Blake Beavan | Texas Rangers | Seattle Mariners | Trade |
| Jul 9, 2010 | Trade | Josh Lueke | Texas Rangers | Seattle Mariners | Trade |
| Jul 9, 2010 | Trade | Matt Lawson | Texas Rangers | Seattle Mariners | Trade |
| Jul 8, 2010 | Released | Hank Blalock | Tampa Bay Rays | — | Release |
| Jul 7, 2010 | Signed as free agent | Mike MacDougal | — | St. Louis Cardinals | Free agent signing |
| Jul 6, 2010 | Released | Garrett Atkins | Baltimore Orioles | — | Release |
| Jul 6, 2010 | Signed as free agent | Luis Figueroa | — | Los Angeles Angels of Anaheim | Free agent signing |
| Jul 6, 2010 | Signed as free agent | Trent Oeltjen | — | Los Angeles Dodgers | Free agent signing |
| Jul 6, 2010 | Released | Dontrelle Willis | Arizona Diamondbacks | — | Release |
| Jul 6, 2010 | Released | Eric Munson | San Diego Padres | — | Release |
| Jul 5, 2010 | Signed as free agent | Mark Worrell | — | Seattle Mariners | Free agent signing |
| Jul 5, 2010 | Signed as free agent | Brian Shouse | — | Tampa Bay Rays | Free agent signing |
| Jul 5, 2010 | Released | Timo Perez | Los Angeles Dodgers | — | Release |
| Jul 4, 2010 | Signed as free agent | Willy Taveras | — | Atlanta Braves | Free agent signing |
| Jul 3, 2010 | Released | Jesus Colome | Los Angeles Dodgers | — | Release |
| Jul 3, 2010 | Released | Ruddy Lugo | Detroit Tigers | — | Release |
| Jul 3, 2010 | Signed as free agent | Argenis Reyes | — | Boston Red Sox | Free agent signing |
| Jul 3, 2010 | Signed as free agent | Drew Meyer | — | Los Angeles Angels of Anaheim | Free agent signing |
| Jul 2, 2010 | Signed as free agent | Boof Bonser | — | Oakland Athletics | Free agent signing |
| Jul 2, 2010 | Signed as free agent | Brian Bruney | — | New York Mets | Free agent signing |
| Jul 2, 2010 | Released | Trent Oeltjen | Milwaukee Brewers | — | Release |
| Jul 2, 2010 | Signed as free agent | Renyel Pinto | — | St. Louis Cardinals | Free agent signing |
| Jul 2, 2010 | Signed as free agent | Orlando Hernandez | — | Washington Nationals | Free agent signing |
| Jul 2, 2010 | Released | Mike Koplove | Seattle Mariners | — | Release |
| Jul 2, 2010 | Signed | Jose Peraza | — | Atlanta Braves | Amateur free agent signing |
| Jul 2, 2010 | Signed | Mauricio Cabrera | — | Atlanta Braves | Amateur free agent signing |
| Jul 2, 2010 | Signed | Renato Nunez | — | Oakland Athletics | Amateur free agent signing |
| Jul 2, 2010 | Signed | Jose Torres | — | Oakland Athletics | Amateur free agent signing |
| Jul 2, 2010 | Signed | Johan Camargo | — | Atlanta Braves | Amateur free agent signing |
| Jul 2, 2010 | Signed | Joel Payamps | — | Colorado Rockies | Amateur free agent signing |
| Jul 1, 2010 | Trade | Kevin Cash | Houston Astros | Boston Red Sox | Trade |
| Jul 1, 2010 | Trade | Angel Sanchez | Boston Red Sox | Houston Astros | Trade |
| Jul 1, 2010 | Trade | Bengie Molina | San Francisco Giants | Texas Rangers | Trade |
| Jul 1, 2010 | Trade | Chris Ray | Texas Rangers | San Francisco Giants | Trade |
| Jul 1, 2010 | Trade | Michael Main | Texas Rangers | San Francisco Giants | Trade |
| Jun 30, 2010 | Released | Luis Figueroa | Toronto Blue Jays | — | Release |
| Jun 30, 2010 | Signed as free agent | Rich Hill | — | Boston Red Sox | Free agent signing |
| Jun 30, 2010 | Signed as free agent | Eric Junge | — | Los Angeles Angels of Anaheim | Free agent signing |
| Jun 29, 2010 | Signed as free agent | Michael Barrett | — | New York Mets | Free agent signing |
| Jun 29, 2010 | Released | Drew Meyer | Houston Astros | — | Release |
| Jun 29, 2010 | Released | Willy Taveras | Philadelphia Phillies | — | Release |
| Jun 29, 2010 | Released | Brian Buscher | Cleveland Indians | — | Release |
| Jun 29, 2010 | Signed as free agent | Jimmy Barthmaier | — | Washington Nationals | Free agent signing |
| Jun 27, 2010 | Signed as free agent | Jack Taschner | — | Los Angeles Dodgers | Free agent signing |
| Jun 26, 2010 | Released | Angel Berroa | San Francisco Giants | — | Release |
| Jun 26, 2010 | Released | Chris Burke | Cincinnati Reds | — | Release |
| Jun 26, 2010 | Trade | Clint Everts | New York Mets | Toronto Blue Jays | Trade |
| Jun 26, 2010 | Trade | Eric Patterson | Oakland Athletics | Boston Red Sox | Trade |
| Jun 26, 2010 | Trade | Fabian Williamson | Boston Red Sox | Oakland Athletics | Trade |
| Jun 26, 2010 | Trade | Russell Branyan | Cleveland Indians | Seattle Mariners | Trade |
| Jun 26, 2010 | Trade | Ezequiel Carrera | Seattle Mariners | Cleveland Indians | Trade |
| Jun 26, 2010 | Trade | Juan Diaz | Seattle Mariners | Cleveland Indians | Trade |
| Jun 24, 2010 | Signed as free agent | Armando Benitez | — | Florida Marlins | Free agent signing |
| Jun 24, 2010 | Signed as free agent | Gary Matthews | — | Cincinnati Reds | Free agent signing |
| Jun 24, 2010 | Signed as free agent | Joe Nelson | — | Seattle Mariners | Free agent signing |
| Jun 24, 2010 | Signed as free agent | Ramon Vazquez | — | Houston Astros | Free agent signing |
| Jun 24, 2010 | Signed | DJ Johnson | — | Tampa Bay Rays | Amateur free agent signing |
| Jun 23, 2010 | Released | Wes Bankston | Texas Rangers | — | Release |
| Jun 23, 2010 | Released | Jimmy Barthmaier | Pittsburgh Pirates | — | Release |
| Jun 23, 2010 | Released | Josh Fogg | Philadelphia Phillies | — | Release |
| Jun 23, 2010 | Released | Renyel Pinto | Florida Marlins | — | Release |
| Jun 23, 2010 | Signed as free agent | Ramon Ortiz | — | New York Mets | Free agent signing |
| Jun 23, 2010 | Released | Alex Romero | Atlanta Braves | — | Release |
| Jun 22, 2010 | Released | Brian Bruney | Milwaukee Brewers | — | Release |
| Jun 22, 2010 | Released | Hunter Jones | Florida Marlins | — | Release |
| Jun 22, 2010 | Released | A. J. Murray | Milwaukee Brewers | — | Release |
| Jun 22, 2010 | Trade | Ross Wolf | Baltimore Orioles | Oakland Athletics | Trade |
| Jun 22, 2010 | Trade | Jake Fox | Oakland Athletics | Baltimore Orioles | Trade |
| Jun 22, 2010 | Signed as free agent | Jesus Colome | — | Los Angeles Dodgers | Free agent signing |
| Jun 21, 2010 | Signed as free agent | D'Angelo Jimenez | — | Minnesota Twins | Free agent signing |
| Jun 18, 2010 | Signed as free agent | Nick Green | — | Toronto Blue Jays | Free agent signing |
| Jun 18, 2010 | Trade | Jorge Padilla | Toronto Blue Jays | New York Mets | Trade |
| Jun 17, 2010 | Signed as free agent | Ryan Shealy | — | Boston Red Sox | Free agent signing |
| Jun 17, 2010 | Signed as free agent | Eric Bruntlett | — | New York Yankees | Free agent signing |
| Jun 16, 2010 | Released | Nick Green | Los Angeles Dodgers | — | Release |
| Jun 16, 2010 | Released | John Parrish | Kansas City Royals | — | Release |
| Jun 16, 2010 | Signed as free agent | Claudio Vargas | — | Los Angeles Dodgers | Free agent signing |
| Jun 16, 2010 | Released | Ramon Vazquez | Seattle Mariners | — | Release |
| Jun 16, 2010 | Signed as free agent | Jamey Wright | — | Oakland Athletics | Free agent signing |
| Jun 15, 2010 | Released | Adam Everett | Detroit Tigers | — | Release |
| Jun 15, 2010 | Released | Gary Matthews | New York Mets | — | Release |
| Jun 15, 2010 | Released | Ryan Shealy | Tampa Bay Rays | — | Release |
| Jun 15, 2010 | Trade | Unnamed | Arizona Diamondbacks | Oakland Athletics | $ |
| Jun 15, 2010 | Trade | Conor Jackson | Arizona Diamondbacks | Oakland Athletics | Trade |
| Jun 15, 2010 | Trade | Sam Demel | Oakland Athletics | Arizona Diamondbacks | Trade |
| Jun 15, 2010 | Signed as free agent | Josh Anderson | — | Atlanta Braves | Free agent signing |
| Jun 15, 2010 | Signed as free agent | Bob McCrory | — | Baltimore Orioles | Free agent signing |
| Jun 15, 2010 | Signed | Casey Lawrence | — | Toronto Blue Jays | Amateur free agent signing |
| Jun 14, 2010 | Signed as free agent | Jeff Suppan | — | St. Louis Cardinals | Free agent signing |
| Jun 14, 2010 | Signed | Nefi Ogando | — | Boston Red Sox | Amateur free agent signing |
| Jun 13, 2010 | Signed as free agent | Marty McLeary | — | Milwaukee Brewers | Free agent signing |
| Jun 12, 2010 | Signed as free agent | Brad Thompson | — | Houston Astros | Free agent signing |
| Jun 11, 2010 | Released | Josh Anderson | Milwaukee Brewers | — | Release |
| Jun 10, 2010 | Signed as free agent | Jason Botts | — | Washington Nationals | Free agent signing |
| Jun 10, 2010 | Signed as free agent | Daniel Cabrera | — | Los Angeles Angels of Anaheim | Free agent signing |
| Jun 10, 2010 | Signed as free agent | Kiko Calero | — | Los Angeles Dodgers | Free agent signing |
| Jun 10, 2010 | Released | Mark Grudzielanek | Cleveland Indians | — | Release |
| Jun 10, 2010 | Released | Jamey Wright | Cleveland Indians | — | Release |
| Jun 10, 2010 | Signed as free agent | Tom Mastny | — | Florida Marlins | Free agent signing |
| Jun 9, 2010 | Released | Marty McLeary | Toronto Blue Jays | — | Release |
| Jun 8, 2010 | Signed as free agent | Scott Patterson | — | Seattle Mariners | Free agent signing |
| Jun 8, 2010 | Signed as free agent | Ben Johnson | — | Detroit Tigers | Free agent signing |
| Jun 7, 2010 | Released | Jeff Suppan | Milwaukee Brewers | — | Release |
| Jun 7, 2010 | Signed as free agent | Billy Traber | — | Seattle Mariners | Free agent signing |
| Jun 7, 2010 | Signed as free agent | Jarrett Grube | — | Seattle Mariners | Free agent signing |
| Jun 5, 2010 | Signed as free agent | Sam Narron | — | Milwaukee Brewers | Free agent signing |
| Jun 5, 2010 | Signed as free agent | Randy Winn | — | St. Louis Cardinals | Free agent signing |
| Jun 5, 2010 | Signed as free agent | Dewayne Wise | — | Toronto Blue Jays | Free agent signing |
| Jun 5, 2010 | Released | Chris Coste | Washington Nationals | — | Release |
| Jun 5, 2010 | Signed as free agent | Fernando Cortez | — | Chicago White Sox | Free agent signing |
| Jun 5, 2010 | Released | Jason Lane | Florida Marlins | — | Release |
| Jun 4, 2010 | Released | Claudio Vargas | Milwaukee Brewers | — | Release |
| Jun 4, 2010 | Released | Josh Phelps | Cleveland Indians | — | Release |
| Jun 3, 2010 | Signed as free agent | Brian Bruney | — | Milwaukee Brewers | Free agent signing |
| Jun 3, 2010 | Released | Ramon Ortiz | Los Angeles Dodgers | — | Release |
| Jun 3, 2010 | Signed as free agent | Willy Taveras | — | Philadelphia Phillies | Free agent signing |
| Jun 3, 2010 | Signed | Wilmer Difo | — | Washington Nationals | Amateur free agent signing |
| Jun 2, 2010 | Released | John Koronka | Los Angeles Dodgers | — | Release |
| Jun 1, 2010 | Trade | Dana Eveland | Toronto Blue Jays | Pittsburgh Pirates | Trade |
| Jun 1, 2010 | Trade | Ronald Uviedo | Pittsburgh Pirates | Toronto Blue Jays | Trade |
| Jun 1, 2010 | Trade | Unnamed | Detroit Tigers | Arizona Diamondbacks | $ |
| Jun 1, 2010 | Trade | Dontrelle Willis | Detroit Tigers | Arizona Diamondbacks | Trade |
| Jun 1, 2010 | Trade | Billy Buckner | Arizona Diamondbacks | Detroit Tigers | Trade |
| May 31, 2010 | Released | Eric Bruntlett | Washington Nationals | — | Release |
| May 31, 2010 | Released | Scott Elarton | Chicago White Sox | — | Release |
| May 31, 2010 | Trade | Jonathan Van Every | Boston Red Sox | Pittsburgh Pirates | Trade |
| May 31, 2010 | Trade | Josue Peley | Pittsburgh Pirates | Boston Red Sox | Trade |
| May 31, 2010 | Signed as free agent | Joe Bisenius | — | Washington Nationals | Free agent signing |
| May 29, 2010 | Signed as free agent | Pat Burrell | — | San Francisco Giants | Free agent signing |
| May 29, 2010 | Signed | Roberto Gomez | — | Tampa Bay Rays | Amateur free agent signing |
| May 28, 2010 | Released | Paul Lo Duca | Colorado Rockies | — | Release |
| May 28, 2010 | Signed as free agent | Matt Watson | — | Oakland Athletics | Free agent signing |
| May 28, 2010 | Released | Randy Winn | New York Yankees | — | Release |
| May 28, 2010 | Released | Alan Embree | Chicago White Sox | — | Release |
| May 27, 2010 | Signed as free agent | Val Majewski | — | Oakland Athletics | Free agent signing |
| May 27, 2010 | Signed as free agent | Jesus Sanchez | — | Oakland Athletics | Free agent signing |
| May 26, 2010 | Signed as free agent | Chad Gaudin | — | New York Yankees | Free agent signing |
| May 26, 2010 | Signed as free agent | Antoan Richardson | — | Atlanta Braves | Free agent signing |
| May 26, 2010 | Signed | Abel De Los Santos | — | Texas Rangers | Amateur free agent signing |
| May 25, 2010 | Signed as free agent | Kazuo Matsui | — | Colorado Rockies | Free agent signing |
| May 25, 2010 | Signed as free agent | Jeff Bennett | — | Milwaukee Brewers | Free agent signing |
| May 25, 2010 | Signed | Jandel Gustave | — | Houston Astros | Amateur free agent signing |
| May 24, 2010 | Released | Brian Bruney | Washington Nationals | — | Release |
| May 24, 2010 | Released | Kazuo Matsui | Houston Astros | — | Release |
| May 24, 2010 | Signed as free agent | John Halama | — | Oakland Athletics | Free agent signing |
| May 22, 2010 | Released | Harvey Garcia | Los Angeles Dodgers | — | Release |
| May 22, 2010 | Signed as free agent | Josh Phelps | — | Cleveland Indians | Free agent signing |
| May 22, 2010 | Signed as free agent | Jon Huber | — | Los Angeles Dodgers | Free agent signing |
| May 21, 2010 | Released | Phil Dumatrait | Detroit Tigers | — | Release |
| May 21, 2010 | Released | Chad Gaudin | Oakland Athletics | — | Release |
| May 21, 2010 | Signed as free agent | Bob Howry | — | Chicago Cubs | Free agent signing |
| May 21, 2010 | Signed as free agent | Rene Rivera | — | New York Yankees | Free agent signing |
| May 21, 2010 | Released | Willy Taveras | Washington Nationals | — | Release |
| May 21, 2010 | Released | Josh Towers | Los Angeles Dodgers | — | Release |
| May 20, 2010 | Signed as free agent | Luis Ayala | — | Arizona Diamondbacks | Free agent signing |
| May 20, 2010 | Signed as free agent | Alejandro Machado | — | Atlanta Braves | Free agent signing |
| May 19, 2010 | Released | Randy Ruiz | Toronto Blue Jays | — | Release |
| May 19, 2010 | Signed as free agent | Michael Feliz | — | Houston Astros | Free agent signing |
| May 18, 2010 | Released | Luis Ayala | Los Angeles Dodgers | — | Release |
| May 17, 2010 | Released | Frank Catalanotto | New York Mets | — | Release |
| May 17, 2010 | Released | Bob Howry | Arizona Diamondbacks | — | Release |
| May 16, 2010 | Released | Kiko Calero | New York Mets | — | Release |
| May 16, 2010 | Signed as free agent | Mike Costanzo | — | Cincinnati Reds | Free agent signing |
| May 16, 2010 | Signed | Breyvic Valera | — | St. Louis Cardinals | Amateur free agent signing |
| May 15, 2010 | Signed as free agent | Kory Casto | — | Arizona Diamondbacks | Free agent signing |
| May 15, 2010 | Released | Jon Huber | Atlanta Braves | — | Release |
| May 15, 2010 | Released | Devern Hansack | Boston Red Sox | — | Release |
| May 14, 2010 | Released | Christian Garcia | New York Yankees | — | Release |
| May 14, 2010 | Released | Scott Lewis | Cleveland Indians | — | Release |
| May 13, 2010 | Signed as free agent | J. R. House | — | New York Mets | Free agent signing |
| May 13, 2010 | Signed as free agent | Tim Redding | — | New York Yankees | Free agent signing |
| May 13, 2010 | Released | Jeff Bennett | Tampa Bay Rays | — | Release |
| May 13, 2010 | Signed as free agent | Travis Blackley | — | Oakland Athletics | Free agent signing |
| May 12, 2010 | Released | Alejandro Machado | Florida Marlins | — | Release |
| May 12, 2010 | Signed as free agent | Josh Anderson | — | Milwaukee Brewers | Free agent signing |
| May 11, 2010 | Released | Shawn Riggans | New York Mets | — | Release |
| May 11, 2010 | Released | Josh Anderson | Cincinnati Reds | — | Release |
| May 11, 2010 | Released | Chris Schroder | Florida Marlins | — | Release |
| May 10, 2010 | Signed as free agent | Alan Embree | — | Chicago White Sox | Free agent signing |
| May 8, 2010 | Signed as free agent | Justin Christian | — | New York Yankees | Free agent signing |
| May 8, 2010 | Released | Jason Waddell | Detroit Tigers | — | Release |
| May 8, 2010 | Released | Yoslan Herrera | Minnesota Twins | — | Release |
| May 6, 2010 | Released | Tim Redding | Colorado Rockies | — | Release |
| May 5, 2010 | Signed as free agent | Doug Mientkiewicz | — | Florida Marlins | Free agent signing |
| May 4, 2010 | Signed as free agent | Travis Denker | — | Los Angeles Dodgers | Free agent signing |
| May 4, 2010 | Released | Roman Colon | Kansas City Royals | — | Release |
| May 3, 2010 | Signed as free agent | Drew Anderson | — | Milwaukee Brewers | Free agent signing |
| May 3, 2010 | Released | Matt DeSalvo | Florida Marlins | — | Release |
| May 3, 2010 | Released | Eric Byrnes | Seattle Mariners | — | Release |
| May 2, 2010 | Released | Travis Blackley | New York Mets | — | Release |
| May 1, 2010 | Trade | Carlos Rosa | Kansas City Royals | Arizona Diamondbacks | Trade |
| May 1, 2010 | Trade | Rey Navarro | Arizona Diamondbacks | Kansas City Royals | Trade |
| Apr 29, 2010 | Signed as free agent | Luis Rodriguez | — | Chicago White Sox | Free agent signing |
| Apr 29, 2010 | Signed | Hector Neris | — | Philadelphia Phillies | Amateur free agent signing |
| Apr 28, 2010 | Signed as free agent | Angel Berroa | — | San Francisco Giants | Free agent signing |
| Apr 28, 2010 | Signed | Socrates Brito | — | Arizona Diamondbacks | Amateur free agent signing |
| Apr 27, 2010 | Signed as free agent | Aaron Miles | — | St. Louis Cardinals | Free agent signing |
| Apr 27, 2010 | Released | Luis Rodriguez | Cleveland Indians | — | Release |
| Apr 26, 2010 | Signed as free agent | Charlie Zink | — | Minnesota Twins | Free agent signing |
| Apr 26, 2010 | Signed | Willy Garcia | — | Pittsburgh Pirates | Amateur free agent signing |
| Apr 24, 2010 | Released | Travis Denker | Seattle Mariners | — | Release |
| Apr 24, 2010 | Trade | Unnamed | Boston Red Sox | Pittsburgh Pirates | player to be named |
| Apr 24, 2010 | Trade | Jonathan Van Every | Pittsburgh Pirates | Boston Red Sox | Trade |
| Apr 23, 2010 | Released | Juan Cruz | Kansas City Royals | — | Release |
| Apr 22, 2010 | Signed as free agent | Deunte Heath | — | Chicago White Sox | Free agent signing |
| Apr 22, 2010 | Released | Russ Ortiz | Los Angeles Dodgers | — | Release |
| Apr 21, 2010 | Signed as free agent | Corey Patterson | — | Baltimore Orioles | Free agent signing |
| Apr 20, 2010 | Signed as free agent | Carlos Martinez | — | St. Louis Cardinals | Free agent signing |
| Apr 20, 2010 | Signed as free agent | Ron Villone | — | Washington Nationals | Free agent signing |
| Apr 20, 2010 | Released | Brian Horwitz | Cleveland Indians | — | Release |
| Apr 20, 2010 | Signed | Richard Rodriguez | — | Houston Astros | Amateur free agent signing |
| Apr 19, 2010 | Signed as free agent | Ramon Vazquez | — | Seattle Mariners | Free agent signing |
| Apr 19, 2010 | Signed as free agent | Joel De La Cruz | — | New York Yankees | Free agent signing |
| Apr 18, 2010 | Released | Jake Woods | Philadelphia Phillies | — | Release |
| Apr 16, 2010 | Released | Francisley Bueno | Atlanta Braves | — | Release |
| Apr 16, 2010 | Signed as free agent | Mike Rivera | — | Los Angeles Dodgers | Free agent signing |
| Apr 16, 2010 | Signed as free agent | Jorge Sosa | — | Florida Marlins | Free agent signing |
| Apr 16, 2010 | Signed as free agent | Brian Sweeney | — | Seattle Mariners | Free agent signing |
| Apr 14, 2010 | Released | Aaron Miles | Cincinnati Reds | — | Release |
| Apr 13, 2010 | Signed | Adeiny Hechavarria | — | Toronto Blue Jays | Amateur free agent signing |
| Apr 9, 2010 | Signed as free agent | Logan Kensing | — | Tampa Bay Rays | Free agent signing |
| Apr 8, 2010 | Released | Deunte Heath | Atlanta Braves | — | Release |
| Apr 8, 2010 | Released | Ramon Vazquez | Pittsburgh Pirates | — | Release |
| Apr 8, 2010 | Released | Curtis Thigpen | Oakland Athletics | — | Release |
| Apr 8, 2010 | Released | Brady Clark | Chicago White Sox | — | Release |
| Apr 7, 2010 | Signed as free agent | Jonah Bayliss | — | Houston Astros | Free agent signing |
| Apr 7, 2010 | Released | Sam Narron | Detroit Tigers | — | Release |
| Apr 7, 2010 | Released | Andy Gonzalez | Baltimore Orioles | — | Release |
| Apr 7, 2010 | Signed as free agent | Alex Romero | — | Atlanta Braves | Free agent signing |
| Apr 6, 2010 | Signed as free agent | Jason Repko | — | Minnesota Twins | Free agent signing |
| Apr 6, 2010 | Signed as free agent | Alejandro Machado | — | Florida Marlins | Free agent signing |
| Apr 5, 2010 | Released | Alejandro Machado | New York Mets | — | Release |
| Apr 5, 2010 | Signed as free agent | Jumbo Diaz | — | Baltimore Orioles | Free agent signing |
| Apr 4, 2010 | Released | Justin Speier | Colorado Rockies | — | Release |
| Apr 3, 2010 | Released | Doug Mientkiewicz | Los Angeles Dodgers | — | Release |
| Apr 3, 2010 | Signed as free agent | Chad Moeller | — | New York Yankees | Free agent signing |
| Apr 3, 2010 | Released | Antoan Richardson | Atlanta Braves | — | Release |
| Apr 3, 2010 | Released | Mike Rivera | New York Yankees | — | Release |
| Apr 3, 2010 | Released | Josh Phelps | Colorado Rockies | — | Release |
| Apr 3, 2010 | Trade | Unnamed | New York Yankees | Colorado Rockies | player to be named |
| Apr 3, 2010 | Trade | Robby Hammock | Colorado Rockies | New York Yankees | Trade |
| Apr 3, 2010 | Signed as free agent | John Van Benschoten | — | New York Yankees | Free agent signing |
| Apr 2, 2010 | Released | Kory Casto | Detroit Tigers | — | Release |
| Apr 2, 2010 | Released | Mike Costanzo | Baltimore Orioles | — | Release |
| Apr 2, 2010 | Released | Kip Wells | Cincinnati Reds | — | Release |
| Apr 2, 2010 | Released | Freddy Guzman | Philadelphia Phillies | — | Release |
| Apr 2, 2010 | Trade | Unnamed | Tampa Bay Rays | Pittsburgh Pirates | player to be named |
| Apr 2, 2010 | Trade | Virgil Vasquez | Pittsburgh Pirates | Tampa Bay Rays | Trade |
| Apr 2, 2010 | Released | Charlton Jimerson | Minnesota Twins | — | Release |
| Apr 2, 2010 | Released | Jumbo Diaz | Texas Rangers | — | Release |
| Apr 1, 2010 | Released | Rick Bauer | Colorado Rockies | — | Release |
| Apr 1, 2010 | Released | Tom Mastny | Cleveland Indians | — | Release |
| Apr 1, 2010 | Released | Chad Moeller | Baltimore Orioles | — | Release |
| Apr 1, 2010 | Released | Jorge Sosa | Boston Red Sox | — | Release |
| Apr 1, 2010 | Released | Vance Wilson | Kansas City Royals | — | Release |
| Apr 1, 2010 | Signed as free agent | Andy Sisco | — | San Francisco Giants | Free agent signing |
| Apr 1, 2010 | Trade | Edwin Escobar | Texas Rangers | San Francisco Giants | Trade |
| Apr 1, 2010 | Trade | Unnamed | San Francisco Giants | Texas Rangers | retention of Rule 5 selection |
| Mar 31, 2010 | Signed as free agent | Josh Fogg | — | Philadelphia Phillies | Free agent signing |
| Mar 31, 2010 | Released | Jason Repko | Los Angeles Dodgers | — | Release |
| Mar 31, 2010 | Signed as free agent | Ty Taubenheim | — | Philadelphia Phillies | Free agent signing |
| Mar 31, 2010 | Released | Francisco Rosario | Kansas City Royals | — | Release |
| Mar 31, 2010 | Released | Mike Burns | Milwaukee Brewers | — | Release |
| Mar 31, 2010 | Released | Argenis Reyes | Los Angeles Dodgers | — | Release |
| Mar 31, 2010 | Released | Travis Chick | Los Angeles Angels of Anaheim | — | Release |
| Mar 31, 2010 | Released | Jonah Bayliss | Toronto Blue Jays | — | Release |
| Mar 31, 2010 | Released | Brian Barton | Los Angeles Dodgers | — | Release |
| Mar 31, 2010 | Released | Mark McLemore | Minnesota Twins | — | Release |
| Mar 30, 2010 | Released | Xavier Cedeno | Colorado Rockies | — | Release |
| Mar 30, 2010 | Signed as free agent | Joey Gathright | — | Baltimore Orioles | Free agent signing |
| Mar 30, 2010 | Released | Seth McClung | Florida Marlins | — | Release |
| Mar 30, 2010 | Released | Scott Patterson | Boston Red Sox | — | Release |
| Mar 30, 2010 | Released | Kevin Millar | Chicago Cubs | — | Release |
| Mar 29, 2010 | Released | Joe Bisenius | Philadelphia Phillies | — | Release |
| Mar 29, 2010 | Signed as free agent | Luis Figueroa | — | Toronto Blue Jays | Free agent signing |
| Mar 29, 2010 | Signed as free agent | Vladimir Nunez | — | Atlanta Braves | Free agent signing |
| Mar 29, 2010 | Released | Brad Wilkerson | Philadelphia Phillies | — | Release |
| Mar 28, 2010 | Signed as free agent | Rick Bauer | — | Colorado Rockies | Free agent signing |
| Mar 28, 2010 | Released | Joey Gathright | Toronto Blue Jays | — | Release |
| Mar 28, 2010 | Signed as free agent | Chad Gaudin | — | Oakland Athletics | Free agent signing |
| Mar 28, 2010 | Released | Jolbert Cabrera | New York Mets | — | Release |
| Mar 27, 2010 | Signed as free agent | Raul Valdes | — | New York Mets | Free agent signing |
| Mar 26, 2010 | Signed as free agent | Scott Schoeneweis | — | Boston Red Sox | Free agent signing |
| Mar 26, 2010 | Released | Charlie Zink | St. Louis Cardinals | — | Release |
| Mar 25, 2010 | Released | Chad Gaudin | New York Yankees | — | Release |
| Mar 25, 2010 | Released | Brian Shouse | Boston Red Sox | — | Release |
| Mar 25, 2010 | Signed as free agent | Scott Elarton | — | Chicago White Sox | Free agent signing |
| Mar 25, 2010 | Released | Andrew Albers | San Diego Padres | — | Release |
| Mar 25, 2010 | Signed | Edubray Ramos | — | St. Louis Cardinals | Amateur free agent signing |
| Mar 24, 2010 | Signed as free agent | Justin Germano | — | Cleveland Indians | Free agent signing |
| Mar 24, 2010 | Signed as free agent | Mike MacDougal | — | Washington Nationals | Free agent signing |
| Mar 24, 2010 | Signed as free agent | Ron Mahay | — | Minnesota Twins | Free agent signing |
| Mar 24, 2010 | Trade | Edwar Ramirez | Texas Rangers | Oakland Athletics | Trade |
| Mar 24, 2010 | Trade | Gregorio Petit | Oakland Athletics | Texas Rangers | Trade |
| Mar 24, 2010 | Signed as free agent | Jeremy Hill | — | Los Angeles Angels of Anaheim | Free agent signing |
| Mar 23, 2010 | Signed as free agent | Joe Beimel | — | Colorado Rockies | Free agent signing |
| Mar 23, 2010 | Released | Mike MacDougal | Florida Marlins | — | Release |
| Mar 23, 2010 | Released | Scott Schoeneweis | Milwaukee Brewers | — | Release |
| Mar 22, 2010 | Released | Angel Berroa | Los Angeles Dodgers | — | Release |
| Mar 22, 2010 | Trade | Ray Olmedo | Texas Rangers | Milwaukee Brewers | Trade |
| Mar 22, 2010 | Trade | Matt Treanor | Milwaukee Brewers | Texas Rangers | Trade |
| Mar 22, 2010 | Released | Eric Gagne | Los Angeles Dodgers | — | Release |
| Mar 21, 2010 | Signed as free agent | Yusmeiro Petit | — | Seattle Mariners | Free agent signing |
| Mar 20, 2010 | Released | Josh Fogg | New York Mets | — | Release |
| Mar 20, 2010 | Signed as free agent | Alan Embree | — | Boston Red Sox | Free agent signing |
| Mar 20, 2010 | Signed as free agent | Carlos Maldonado | — | Washington Nationals | Free agent signing |
| Mar 20, 2010 | Signed as free agent | Casey Fien | — | Detroit Tigers | Free agent signing |
| Mar 19, 2010 | Signed as free agent | Miguel Perez | — | Cleveland Indians | Free agent signing |
| Mar 18, 2010 | Trade | Miguel Celestino | Seattle Mariners | Boston Red Sox | Trade |
| Mar 18, 2010 | Released | Casey Fien | Toronto Blue Jays | — | Release |
| Mar 17, 2010 | Signed as free agent | Kris Benson | — | Arizona Diamondbacks | Free agent signing |
| Mar 17, 2010 | Released | Jason Botts | Chicago White Sox | — | Release |
| Mar 17, 2010 | Released | Daniel Cabrera | Chicago White Sox | — | Release |
| Mar 17, 2010 | Released | Logan Kensing | Washington Nationals | — | Release |
| Mar 17, 2010 | Released | Yusmeiro Petit | Seattle Mariners | — | Release |
| Mar 17, 2010 | Released | Alex Romero | Houston Astros | — | Release |
| Mar 17, 2010 | Released | Elijah Dukes | Washington Nationals | — | Release |
| Mar 17, 2010 | Released | Derrick Turnbow | Florida Marlins | — | Release |
| Mar 16, 2010 | Released | John Halama | Milwaukee Brewers | — | Release |
| Mar 15, 2010 | Released | Ron Villone | Washington Nationals | — | Release |
| Mar 15, 2010 | Signed as free agent | Chris Aguila | — | Toronto Blue Jays | Free agent signing |
| Mar 15, 2010 | Released | Keith Ginter | Chicago White Sox | — | Release |
| Mar 13, 2010 | Signed as free agent | Matt Kata | — | Houston Astros | Free agent signing |
| Mar 12, 2010 | Signed as free agent | Hank Blalock | — | Tampa Bay Rays | Free agent signing |
| Mar 10, 2010 | Released | Eddie Guardado | Washington Nationals | — | Release |
| Mar 10, 2010 | Released | Shawn Estes | Washington Nationals | — | Release |
| Mar 10, 2010 | Released | Jay Marshall | Oakland Athletics | — | Release |
| Mar 8, 2010 | Signed as free agent | Mike O'Connor | — | New York Mets | Free agent signing |
| Mar 7, 2010 | Signed as free agent | Brad Eldred | — | Colorado Rockies | Free agent signing |
| Mar 7, 2010 | Signed as free agent | Brandon Mann | — | Los Angeles Dodgers | Free agent signing |
| Mar 6, 2010 | Released | Michael Hollimon | Detroit Tigers | — | Release |
| Mar 6, 2010 | Signed as free agent | Scott Rice | — | Colorado Rockies | Free agent signing |
| Mar 5, 2010 | Signed as free agent | Travis Metcalf | — | Colorado Rockies | Free agent signing |
| Mar 4, 2010 | Signed as free agent | Kiko Calero | — | New York Mets | Free agent signing |
| Mar 3, 2010 | Signed as free agent | Garret Anderson | — | Los Angeles Dodgers | Free agent signing |
| Mar 3, 2010 | Signed as free agent | Tom Wilhelmsen | — | Seattle Mariners | Free agent signing |
| Mar 2, 2010 | Signed as free agent | Brad Hennessey | — | Minnesota Twins | Free agent signing |
| Mar 2, 2010 | Signed as free agent | Yoslan Herrera | — | Minnesota Twins | Free agent signing |
| Mar 1, 2010 | Signed as free agent | Wes Littleton | — | Seattle Mariners | Free agent signing |
| Mar 1, 2010 | Signed as free agent | Tom Mastny | — | Cleveland Indians | Free agent signing |
| Mar 1, 2010 | Signed as free agent | Matt Kinney | — | San Francisco Giants | Free agent signing |
| Feb 28, 2010 | Signed as free agent | Chan Ho Park | — | New York Yankees | Free agent signing |
| Feb 28, 2010 | Signed as free agent | Jason Jennings | — | Oakland Athletics | Free agent signing |
| Feb 28, 2010 | Signed as free agent | Brett Tomko | — | Oakland Athletics | Free agent signing |
| Feb 27, 2010 | Signed as free agent | Felipe Lopez | — | St. Louis Cardinals | Free agent signing |
| Feb 25, 2010 | Signed as free agent | Eric Munson | — | San Diego Padres | Free agent signing |
| Feb 25, 2010 | Released | Khalil Greene | Texas Rangers | — | Release |
| Feb 24, 2010 | Signed as free agent | Rod Barajas | — | New York Mets | Free agent signing |
| Feb 24, 2010 | Signed as free agent | Russell Branyan | — | Cleveland Indians | Free agent signing |
| Feb 24, 2010 | Signed as free agent | Livan Hernandez | — | Washington Nationals | Free agent signing |
| Feb 24, 2010 | Signed as free agent | Wes Bankston | — | Texas Rangers | Free agent signing |
| Feb 23, 2010 | Signed as free agent | Brad Wilkerson | — | Philadelphia Phillies | Free agent signing |
| Feb 23, 2010 | Signed as free agent | Jacque Jones | — | Minnesota Twins | Free agent signing |
| Feb 23, 2010 | Signed as free agent | Matt Stairs | — | San Diego Padres | Free agent signing |
| Feb 23, 2010 | Signed | Ronald Torreyes | — | Cincinnati Reds | Amateur free agent signing |
| Feb 23, 2010 | Signed | Alejandro Chacin | — | Cincinnati Reds | Amateur free agent signing |
| Feb 22, 2010 | Signed as free agent | Johnny Damon | — | Detroit Tigers | Free agent signing |
| Feb 22, 2010 | Signed as free agent | Jonny Gomes | — | Cincinnati Reds | Free agent signing |
| Feb 21, 2010 | Released | Freddie Bynum | Chicago White Sox | — | Release |
| Feb 21, 2010 | Signed as free agent | Tim Redding | — | Colorado Rockies | Free agent signing |
| Feb 20, 2010 | Released | Edwin Moreno | Boston Red Sox | — | Release |
| Feb 20, 2010 | Signed as free agent | Josh Barfield | — | San Diego Padres | Free agent signing |
| Feb 19, 2010 | Signed as free agent | Jose Molina | — | Toronto Blue Jays | Free agent signing |
| Feb 18, 2010 | Signed as free agent | Greg Burke | — | San Diego Padres | Free agent signing |
| Feb 18, 2010 | Signed as free agent | Mike MacDougal | — | Florida Marlins | Free agent signing |
| Feb 17, 2010 | Signed as free agent | Nick Bierbrodt | — | Colorado Rockies | Free agent signing |
| Feb 17, 2010 | Signed as free agent | Chris Resop | — | Atlanta Braves | Free agent signing |
| Feb 17, 2010 | Signed as free agent | Ron Villone | — | Washington Nationals | Free agent signing |
| Feb 17, 2010 | Signed as free agent | Rafael Martin | — | Washington Nationals | Free agent signing with first major-league team |
| Feb 16, 2010 | Signed as free agent | Charlton Jimerson | — | Minnesota Twins | Free agent signing |
| Feb 16, 2010 | Signed as free agent | Dustin Moseley | — | New York Yankees | Free agent signing |
| Feb 16, 2010 | Signed as free agent | Chien-Ming Wang | — | Washington Nationals | Free agent signing |
| Feb 15, 2010 | Signed as free agent | Joaquin Benoit | — | Tampa Bay Rays | Free agent signing |
| Feb 15, 2010 | Signed as free agent | Endy Chavez | — | Texas Rangers | Free agent signing |
| Feb 15, 2010 | Signed as free agent | Daniel Davidson | — | Los Angeles Angels of Anaheim | Free agent signing |
| Feb 15, 2010 | Signed as free agent | Stu Pomeranz | — | Colorado Rockies | Free agent signing |
| Feb 15, 2010 | Signed as free agent | Willy Taveras | — | Washington Nationals | Free agent signing |
| Feb 12, 2010 | Signed as free agent | Adam Kennedy | — | Washington Nationals | Free agent signing |
| Feb 12, 2010 | Signed as free agent | Paul McAnulty | — | Los Angeles Angels of Anaheim | Free agent signing |
| Feb 12, 2010 | Signed as free agent | Mike Sweeney | — | Seattle Mariners | Free agent signing |
| Feb 11, 2010 | Signed as free agent | Alex Cintron | — | New York Mets | Free agent signing |
| Feb 11, 2010 | Signed as free agent | Mike Jacobs | — | New York Mets | Free agent signing |
| Feb 11, 2010 | Signed as free agent | Mike Lamb | — | Florida Marlins | Free agent signing |
| Feb 11, 2010 | Signed as free agent | Robb Quinlan | — | Los Angeles Angels of Anaheim | Free agent signing |
| Feb 11, 2010 | Signed as free agent | Shawn Riggans | — | New York Mets | Free agent signing |
| Feb 11, 2010 | Signed as free agent | Mark Saccomanno | — | Florida Marlins | Free agent signing |
| Feb 11, 2010 | Signed as free agent | Hisanori Takahashi | — | New York Mets | Free agent signing with first major-league team |
| Feb 11, 2010 | Signed as free agent | Kip Wells | — | Cincinnati Reds | Free agent signing |
| Feb 11, 2010 | Signed | Michael Feliz | — | Oakland Athletics | Amateur free agent signing |
| Feb 10, 2010 | Signed as free agent | Jesus Colome | — | Seattle Mariners | Free agent signing |
| Feb 10, 2010 | Signed as free agent | Marcus Thames | — | New York Yankees | Free agent signing |
| Feb 10, 2010 | Signed as free agent | Todd Wellemeyer | — | San Francisco Giants | Free agent signing |
| Feb 10, 2010 | Signed as free agent | Mark Worrell | — | San Diego Padres | Free agent signing |
| Feb 9, 2010 | Released | Greg Burke | San Diego Padres | — | Release |
| Feb 9, 2010 | Signed as free agent | Angel Chavez | — | Tampa Bay Rays | Free agent signing |
| Feb 9, 2010 | Signed as free agent | Brian Giles | — | Los Angeles Dodgers | Free agent signing |
| Feb 9, 2010 | Signed as free agent | Mark Hendrickson | — | Baltimore Orioles | Free agent signing |
| Feb 9, 2010 | Signed as free agent | Bobby Korecky | — | Los Angeles Angels of Anaheim | Free agent signing |
| Feb 9, 2010 | Signed as free agent | Will Ohman | — | Baltimore Orioles | Free agent signing |
| Feb 9, 2010 | Signed as free agent | Scott Schoeneweis | — | Milwaukee Brewers | Free agent signing |
| Feb 9, 2010 | Released | Willy Taveras | Oakland Athletics | — | Release |
| Feb 9, 2010 | Signed as free agent | Jamey Wright | — | Cleveland Indians | Free agent signing |
| Feb 8, 2010 | Signed as free agent | Randy Winn | — | New York Yankees | Free agent signing |
| Feb 8, 2010 | Signed as free agent | Chase Wright | — | Milwaukee Brewers | Free agent signing |
| Feb 7, 2010 | Signed as free agent | Shawn Estes | — | Washington Nationals | Free agent signing |
| Feb 6, 2010 | Signed as free agent | Andrew Brown | — | Washington Nationals | Free agent signing |
| Feb 6, 2010 | Signed as free agent | Jason Dubois | — | Chicago Cubs | Free agent signing |
| Feb 6, 2010 | Signed as free agent | Jason Lane | — | Florida Marlins | Free agent signing |
| Feb 5, 2010 | Signed as free agent | J. J. Furmaniak | — | Tampa Bay Rays | Free agent signing |
| Feb 5, 2010 | Signed as free agent | Josh Phelps | — | Colorado Rockies | Free agent signing |
| Feb 5, 2010 | Signed as free agent | Yorvit Torrealba | — | San Diego Padres | Free agent signing |
| Feb 5, 2010 | Signed as free agent | Oscar Villarreal | — | Philadelphia Phillies | Free agent signing |
| Feb 4, 2010 | Signed as free agent | Erik Bedard | — | Seattle Mariners | Free agent signing |
| Feb 4, 2010 | Signed as free agent | Joel Guzman | — | Baltimore Orioles | Free agent signing |
| Feb 4, 2010 | Signed as free agent | Orlando Hudson | — | Minnesota Twins | Free agent signing |
| Feb 4, 2010 | Signed as free agent | J. D. Martin | — | Washington Nationals | Free agent signing |
| Feb 3, 2010 | Signed as free agent | Alfredo Amezaga | — | Los Angeles Dodgers | Free agent signing |
| Feb 3, 2010 | Signed as free agent | Seth Etherton | — | Los Angeles Dodgers | Free agent signing |
| Feb 3, 2010 | Signed as free agent | Luis Hernandez | — | New York Mets | Free agent signing |
| Feb 3, 2010 | Signed as free agent | Bobby Livingston | — | New York Mets | Free agent signing |
| Feb 3, 2010 | Signed as free agent | Mike Maroth | — | Minnesota Twins | Free agent signing |
| Feb 3, 2010 | Signed as free agent | Kevin Mench | — | Washington Nationals | Free agent signing |
| Feb 3, 2010 | Signed as free agent | Kevin Millar | — | Chicago Cubs | Free agent signing |
| Feb 3, 2010 | Signed as free agent | Mike Ryan | — | Los Angeles Angels of Anaheim | Free agent signing |
| Feb 2, 2010 | Signed as free agent | Kevin Gregg | — | Toronto Blue Jays | Free agent signing |
| Feb 2, 2010 | Signed as free agent | Seth McClung | — | Florida Marlins | Free agent signing |
| Feb 2, 2010 | Signed as free agent | Guillermo Mota | — | San Francisco Giants | Free agent signing |
| Feb 2, 2010 | Signed as free agent | Neal Musser | — | New York Mets | Free agent signing |
| Feb 2, 2010 | Signed as free agent | Ramon Ortiz | — | Los Angeles Dodgers | Free agent signing |
| Feb 2, 2010 | Signed as free agent | Jae Kuk Ryu | — | Texas Rangers | Free agent signing |
| Feb 2, 2010 | Signed as free agent | Bronson Sardinha | — | Colorado Rockies | Free agent signing |
| Feb 2, 2010 | Signed as free agent | Craig Stansberry | — | San Diego Padres | Free agent signing |
| Feb 2, 2010 | Signed as free agent | Jeff Weaver | — | Los Angeles Dodgers | Free agent signing |
| Feb 2, 2010 | Signed | Wander Suero | — | Washington Nationals | Amateur free agent signing |
| Feb 2, 2010 | Signed | Robel Garcia | — | Cleveland Indians | Amateur free agent signing |
| Feb 1, 2010 | Signed as free agent | Jonah Bayliss | — | Toronto Blue Jays | Free agent signing |
| Feb 1, 2010 | Signed as free agent | Orlando Cabrera | — | Cincinnati Reds | Free agent signing |
| Feb 1, 2010 | Signed as free agent | Ryan Garko | — | Seattle Mariners | Free agent signing |
| Feb 1, 2010 | Signed as free agent | Jimmy Gobble | — | Colorado Rockies | Free agent signing |
| Feb 1, 2010 | Signed as free agent | Reed Johnson | — | Los Angeles Dodgers | Free agent signing |
| Feb 1, 2010 | Signed as free agent | Joe Nelson | — | Boston Red Sox | Free agent signing |
| Feb 1, 2010 | Signed as free agent | Horacio Ramirez | — | San Francisco Giants | Free agent signing |
| Feb 1, 2010 | Signed as free agent | Justin Speier | — | Colorado Rockies | Free agent signing |
| Feb 1, 2010 | Trade | Unnamed | Oakland Athletics | Cincinnati Reds | a player to be named |
| Feb 1, 2010 | Trade | Aaron Miles | Oakland Athletics | Cincinnati Reds | Trade |
| Feb 1, 2010 | Trade | Willy Taveras | Cincinnati Reds | Oakland Athletics | Trade |
| Feb 1, 2010 | Trade | Adam Rosales | Cincinnati Reds | Oakland Athletics | Trade |
| Jan 31, 2010 | Signed as free agent | Gabe Gross | — | Oakland Athletics | Free agent signing |
| Jan 31, 2010 | Signed as free agent | Melvin Mora | — | Colorado Rockies | Free agent signing |
| Jan 30, 2010 | Signed as free agent | Scott Munter | — | San Diego Padres | Free agent signing |
| Jan 29, 2010 | Signed as free agent | Miguel Batista | — | Washington Nationals | Free agent signing |
| Jan 29, 2010 | Signed as free agent | Doug Bernier | — | Pittsburgh Pirates | Free agent signing |
| Jan 29, 2010 | Signed as free agent | Travis Blackley | — | New York Mets | Free agent signing |
| Jan 29, 2010 | Signed as free agent | Eric Byrnes | — | Seattle Mariners | Free agent signing |
| Jan 29, 2010 | Signed as free agent | Frank Catalanotto | — | New York Mets | Free agent signing |
| Jan 29, 2010 | Signed as free agent | Howie Clark | — | Toronto Blue Jays | Free agent signing |
| Jan 29, 2010 | Signed as free agent | Josh Fogg | — | New York Mets | Free agent signing |
| Jan 29, 2010 | Signed as free agent | Brian Gordon | — | Philadelphia Phillies | Free agent signing |
| Jan 29, 2010 | Signed as free agent | Carlos Guevara | — | Colorado Rockies | Free agent signing |
| Jan 29, 2010 | Signed as free agent | Kevin Melillo | — | Pittsburgh Pirates | Free agent signing |
| Jan 29, 2010 | Signed as free agent | Derrick Turnbow | — | Florida Marlins | Free agent signing |
| Jan 29, 2010 | Signed as free agent | Jose Veras | — | Florida Marlins | Free agent signing |
| Jan 28, 2010 | Signed as free agent | Daniel Cabrera | — | Chicago White Sox | Free agent signing |
| Jan 28, 2010 | Signed as free agent | Jim Edmonds | — | Milwaukee Brewers | Free agent signing |
| Jan 28, 2010 | Signed as free agent | Justin Knoedler | — | Los Angeles Dodgers | Free agent signing |
| Jan 28, 2010 | Signed as free agent | Val Pascucci | — | New York Mets | Free agent signing |
| Jan 28, 2010 | Signed as free agent | Fernando Tatis | — | New York Mets | Free agent signing |
| Jan 28, 2010 | Signed | Eduardo Rodriguez | — | Baltimore Orioles | Amateur free agent signing |
| Jan 27, 2010 | Signed as free agent | Miguel Cairo | — | Cincinnati Reds | Free agent signing |
| Jan 27, 2010 | Signed as free agent | Dan Giese | — | Oakland Athletics | Free agent signing |
| Jan 27, 2010 | Signed as free agent | Chris Gissell | — | Colorado Rockies | Free agent signing |
| Jan 27, 2010 | Signed as free agent | Heath Phillips | — | Tampa Bay Rays | Free agent signing |
| Jan 26, 2010 | Signed as free agent | Brad Ausmus | — | Los Angeles Dodgers | Free agent signing |
| Jan 26, 2010 | Signed as free agent | Ronnie Belliard | — | Los Angeles Dodgers | Free agent signing |
| Jan 26, 2010 | Signed as free agent | Jon Garland | — | San Diego Padres | Free agent signing |
| Jan 26, 2010 | Signed as free agent | Freddy Guzman | — | Philadelphia Phillies | Free agent signing |
| Jan 26, 2010 | Signed as free agent | Rich Hill | — | St. Louis Cardinals | Free agent signing |
| Jan 26, 2010 | Signed as free agent | Damian Moss | — | Colorado Rockies | Free agent signing |
| Jan 26, 2010 | Signed as free agent | Xavier Nady | — | Chicago Cubs | Free agent signing |
| Jan 26, 2010 | Signed as free agent | Timo Perez | — | Los Angeles Dodgers | Free agent signing |
| Jan 26, 2010 | Signed as free agent | Rich Rundles | — | St. Louis Cardinals | Free agent signing |
| Jan 26, 2010 | Signed as free agent | Ben Sheets | — | Oakland Athletics | Free agent signing |
| Jan 26, 2010 | Signed as free agent | Jim Thome | — | Minnesota Twins | Free agent signing |
| Jan 26, 2010 | Trade | Unnamed | New York Yankees | Texas Rangers | $ |
| Jan 26, 2010 | Trade | Mitch Hilligoss | New York Yankees | Texas Rangers | Trade |
| Jan 26, 2010 | Trade | Greg Golson | Texas Rangers | New York Yankees | Trade |
| Jan 25, 2010 | Signed as free agent | Kevin Cash | — | Houston Astros | Free agent signing |
| Jan 25, 2010 | Signed as free agent | Chuck James | — | Washington Nationals | Free agent signing |
| Jan 25, 2010 | Signed as free agent | Luis Maza | — | Philadelphia Phillies | Free agent signing |
| Jan 25, 2010 | Signed as free agent | Chad Tracy | — | Chicago Cubs | Free agent signing |
| Jan 25, 2010 | Signed as free agent | Tyler Walker | — | Washington Nationals | Free agent signing |
| Jan 25, 2010 | Signed as free agent | Devern Hansack | — | Boston Red Sox | Free agent signing |
| Jan 25, 2010 | Signed as free agent | Matt Bush | — | Tampa Bay Rays | Free agent signing |
| Jan 23, 2010 | Signed as free agent | Jason Giambi | — | Colorado Rockies | Free agent signing |
| Jan 23, 2010 | Signed as free agent | Robby Hammock | — | Colorado Rockies | Free agent signing |
| Jan 23, 2010 | Signed as free agent | Miguel Tejada | — | Baltimore Orioles | Free agent signing |
| Jan 22, 2010 | Signed as free agent | Jose Arredondo | — | Cincinnati Reds | Free agent signing |
| Jan 22, 2010 | Signed as free agent | Jose Contreras | — | Philadelphia Phillies | Free agent signing |
| Jan 22, 2010 | Signed as free agent | Doug Davis | — | Milwaukee Brewers | Free agent signing |
| Jan 22, 2010 | Signed as free agent | Scott Dohmann | — | Los Angeles Dodgers | Free agent signing |
| Jan 22, 2010 | Signed as free agent | Nick Green | — | Los Angeles Dodgers | Free agent signing |
| Jan 22, 2010 | Signed as free agent | John Koronka | — | Los Angeles Dodgers | Free agent signing |
| Jan 22, 2010 | Signed as free agent | Brian Lawrence | — | Florida Marlins | Free agent signing |
| Jan 22, 2010 | Signed as free agent | Russ Ortiz | — | Los Angeles Dodgers | Free agent signing |
| Jan 22, 2010 | Signed as free agent | Michael Restovich | — | Los Angeles Dodgers | Free agent signing |
| Jan 22, 2010 | Trade | Unnamed | Los Angeles Angels of Anaheim | New York Mets | $ |
| Jan 22, 2010 | Trade | Gary Matthews | Los Angeles Angels of Anaheim | New York Mets | Trade |
| Jan 22, 2010 | Trade | Brian Stokes | New York Mets | Los Angeles Angels of Anaheim | Trade |
| Jan 21, 2010 | Signed as free agent | Rick Ankiel | — | Kansas City Royals | Free agent signing |
| Jan 21, 2010 | Signed as free agent | Denny Bautista | — | San Francisco Giants | Free agent signing |
| Jan 21, 2010 | Signed as free agent | Harvey Garcia | — | Los Angeles Dodgers | Free agent signing |
| Jan 21, 2010 | Signed as free agent | Khalil Greene | — | Texas Rangers | Free agent signing |
| Jan 21, 2010 | Signed as free agent | Shawn Hill | — | Toronto Blue Jays | Free agent signing |
| Jan 21, 2010 | Signed as free agent | Paul Lo Duca | — | Colorado Rockies | Free agent signing |
| Jan 21, 2010 | Signed as free agent | Mark McLemore | — | Minnesota Twins | Free agent signing |
| Jan 21, 2010 | Signed as free agent | Vicente Padilla | — | Los Angeles Dodgers | Free agent signing |
| Jan 21, 2010 | Signed as free agent | Jay Payton | — | Colorado Rockies | Free agent signing |
| Jan 21, 2010 | Signed as free agent | Jared Wells | — | Houston Astros | Free agent signing |
| Jan 20, 2010 | Released | Eric Byrnes | Arizona Diamondbacks | — | Release |
| Jan 20, 2010 | Signed as free agent | D. J. Carrasco | — | Pittsburgh Pirates | Free agent signing |
| Jan 20, 2010 | Signed as free agent | Octavio Dotel | — | Pittsburgh Pirates | Free agent signing |
| Jan 20, 2010 | Signed as free agent | Juan Mateo | — | Los Angeles Angels of Anaheim | Free agent signing |
| Jan 20, 2010 | Signed as free agent | Joel Pineiro | — | Los Angeles Angels of Anaheim | Free agent signing |
| Jan 20, 2010 | Signed as free agent | Mike Rabelo | — | Detroit Tigers | Free agent signing |
| Jan 20, 2010 | Signed as free agent | Cory Sullivan | — | Houston Astros | Free agent signing |
| Jan 19, 2010 | Signed as free agent | Chris Duncan | — | Washington Nationals | Free agent signing |
| Jan 19, 2010 | Signed as free agent | Mark Grudzielanek | — | Cleveland Indians | Free agent signing |
| Jan 19, 2010 | Released | Luis Hernandez | Kansas City Royals | — | Release |
| Jan 19, 2010 | Signed as free agent | Colby Lewis | — | Texas Rangers | Free agent signing |
| Jan 19, 2010 | Released | J. D. Martin | Washington Nationals | — | Release |
| Jan 19, 2010 | Signed as free agent | Bengie Molina | — | San Francisco Giants | Free agent signing |
| Jan 19, 2010 | Signed as free agent | Gustavo Molina | — | Boston Red Sox | Free agent signing |
| Jan 19, 2010 | Signed as free agent | Sam Narron | — | Detroit Tigers | Free agent signing |
| Jan 19, 2010 | Signed as free agent | Steven Register | — | Toronto Blue Jays | Free agent signing |
| Jan 19, 2010 | Signed as free agent | Jose Valverde | — | Detroit Tigers | Free agent signing |
| Jan 19, 2010 | Signed | Jorge Alfaro | — | Texas Rangers | Amateur free agent signing |
| Jan 18, 2010 | Signed as free agent | Jerry Hairston | — | San Diego Padres | Free agent signing |
| Jan 18, 2010 | Signed as free agent | Shane Loux | — | Houston Astros | Free agent signing |
| Jan 18, 2010 | Signed as free agent | Ruddy Lugo | — | Detroit Tigers | Free agent signing |
| Jan 18, 2010 | Signed as free agent | Chad Paronto | — | Boston Red Sox | Free agent signing |
| Jan 18, 2010 | Signed as free agent | Jeremy Reed | — | Toronto Blue Jays | Free agent signing |
| Jan 18, 2010 | Released | Brad Wilkerson | Boston Red Sox | — | Release |
| Jan 18, 2010 | Trade | Brian Bixler | Pittsburgh Pirates | Cleveland Indians | Trade |
| Jan 18, 2010 | Trade | Jesus Brito | Cleveland Indians | Pittsburgh Pirates | Trade |
| Jan 16, 2010 | Signed as free agent | Brendan Donnelly | — | Pittsburgh Pirates | Free agent signing |
| Jan 16, 2010 | Released | Walter Silva | San Diego Padres | — | Release |
| Jan 16, 2010 | Trade | Aaron Cunningham | Oakland Athletics | San Diego Padres | Trade |
| Jan 16, 2010 | Trade | Scott Hairston | Oakland Athletics | San Diego Padres | Trade |
| Jan 16, 2010 | Trade | Kevin Kouzmanoff | San Diego Padres | Oakland Athletics | Trade |
| Jan 16, 2010 | Trade | Eric Sogard | San Diego Padres | Oakland Athletics | Trade |
| Jan 16, 2010 | Signed as free agent | Jamie Romak | — | Kansas City Royals | Free agent signing |
| Jan 15, 2010 | Signed as free agent | Jolbert Cabrera | — | New York Mets | Free agent signing |
| Jan 15, 2010 | Signed as free agent | Carlos Muniz | — | New York Mets | Free agent signing |
| Jan 15, 2010 | Signed as free agent | Mike Redmond | — | Cleveland Indians | Free agent signing |
| Jan 15, 2010 | Signed as free agent | Jeff Salazar | — | Baltimore Orioles | Free agent signing |
| Jan 14, 2010 | Signed as free agent | Mark Johnson | — | Chicago Cubs | Free agent signing |
| Jan 14, 2010 | Signed as free agent | Scott McClain | — | Chicago Cubs | Free agent signing |
| Jan 13, 2010 | Signed as free agent | Kory Casto | — | Detroit Tigers | Free agent signing |
| Jan 13, 2010 | Signed as free agent | Brandon Duckworth | — | Philadelphia Phillies | Free agent signing |
| Jan 13, 2010 | Signed as free agent | Adam LaRoche | — | Arizona Diamondbacks | Free agent signing |
| Jan 13, 2010 | Signed as free agent | Pedro Lopez | — | Washington Nationals | Free agent signing |
| Jan 13, 2010 | Signed as free agent | Jorge Sosa | — | Boston Red Sox | Free agent signing |
| Jan 13, 2010 | Signed as free agent | Eider Torres | — | Colorado Rockies | Free agent signing |
| Jan 13, 2010 | Signed as free agent | Jason Waddell | — | Detroit Tigers | Free agent signing |
| Jan 13, 2010 | Signed as free agent | Charlie Zink | — | St. Louis Cardinals | Free agent signing |
| Jan 13, 2010 | Signed | Maikel Franco | — | Philadelphia Phillies | Amateur free agent signing |
| Jan 12, 2010 | Signed as free agent | Jeff Bailey | — | Arizona Diamondbacks | Free agent signing |
| Jan 12, 2010 | Signed as free agent | Brian Bass | — | Pittsburgh Pirates | Free agent signing |
| Jan 12, 2010 | Signed as free agent | Ramon Castro | — | Chicago White Sox | Free agent signing |
| Jan 12, 2010 | Signed as free agent | JD Closser | — | Los Angeles Dodgers | Free agent signing |
| Jan 12, 2010 | Signed as free agent | Alvin Colina | — | Tampa Bay Rays | Free agent signing |
| Jan 12, 2010 | Signed as free agent | Jay Gibbons | — | Los Angeles Dodgers | Free agent signing |
| Jan 12, 2010 | Signed as free agent | Brad Nelson | — | Seattle Mariners | Free agent signing |
| Jan 12, 2010 | Signed as free agent | Argenis Reyes | — | Los Angeles Dodgers | Free agent signing |
| Jan 12, 2010 | Signed as free agent | Antoan Richardson | — | Atlanta Braves | Free agent signing |
| Jan 11, 2010 | Signed | Aroldis Chapman | — | Cincinnati Reds | Amateur free agent signing |
| Jan 11, 2010 | Signed as free agent | Ryan Church | — | Pittsburgh Pirates | Free agent signing |
| Jan 11, 2010 | Signed as free agent | Shelley Duncan | — | Cleveland Indians | Free agent signing |
| Jan 11, 2010 | Signed as free agent | Andy Gonzalez | — | Baltimore Orioles | Free agent signing |
| Jan 11, 2010 | Signed as free agent | Norris Hopper | — | Milwaukee Brewers | Free agent signing |
| Jan 11, 2010 | Signed as free agent | Dan Johnson | — | Tampa Bay Rays | Free agent signing |
| Jan 11, 2010 | Signed as free agent | Austin Kearns | — | Cleveland Indians | Free agent signing |
| Jan 11, 2010 | Signed as free agent | Justin Lehr | — | Cincinnati Reds | Free agent signing |
| Jan 11, 2010 | Signed as free agent | Jailen Peguero | — | Texas Rangers | Free agent signing |
| Jan 11, 2010 | Signed as free agent | Adam Pettyjohn | — | New York Mets | Free agent signing |
| Jan 10, 2010 | Signed as free agent | Matthew Brown | — | Texas Rangers | Free agent signing |
| Jan 10, 2010 | Signed as free agent | Matt Herges | — | Kansas City Royals | Free agent signing |
| Jan 10, 2010 | Signed as free agent | Aubrey Huff | — | San Francisco Giants | Free agent signing |
| Jan 10, 2010 | Signed as free agent | Elizardo Ramirez | — | Texas Rangers | Free agent signing |
| Jan 9, 2010 | Signed as free agent | Vladimir Guerrero | — | Texas Rangers | Free agent signing |
| Jan 9, 2010 | Signed as free agent | Bryan LaHair | — | Chicago Cubs | Free agent signing |
| Jan 9, 2010 | Released | Ryan Sadowski | Houston Astros | — | Release |
| Jan 8, 2010 | Signed as free agent | Jesus Delgado | — | Cincinnati Reds | Free agent signing |
| Jan 8, 2010 | Signed as free agent | Brett Myers | — | Houston Astros | Free agent signing |
| Jan 8, 2010 | Signed as free agent | Scott Podsednik | — | Kansas City Royals | Free agent signing |
| Jan 7, 2010 | Signed as free agent | Willie Collazo | — | Toronto Blue Jays | Free agent signing |
| Jan 7, 2010 | Signed as free agent | Jack Cust | — | Oakland Athletics | Free agent signing |
| Jan 7, 2010 | Signed as free agent | Lenny DiNardo | — | Oakland Athletics | Free agent signing |
| Jan 7, 2010 | Released | Bob McCrory | Boston Red Sox | — | Release |
| Jan 7, 2010 | Signed as free agent | Jorge Padilla | — | Toronto Blue Jays | Free agent signing |
| Jan 7, 2010 | Signed as free agent | Scott Patterson | — | Boston Red Sox | Free agent signing |
| Jan 7, 2010 | Signed as free agent | Jason Standridge | — | Philadelphia Phillies | Free agent signing |
| Jan 7, 2010 | Signed as free agent | Luis Terrero | — | Cincinnati Reds | Free agent signing |
| Jan 7, 2010 | Trade | Bill Hall | Seattle Mariners | Boston Red Sox | Trade |
| Jan 7, 2010 | Trade | Casey Kotchman | Boston Red Sox | Seattle Mariners | Trade |
| Jan 7, 2010 | Signed as free agent | Brock Peterson | — | Minnesota Twins | Free agent signing |
| Jan 6, 2010 | Signed as free agent | Josh Anderson | — | Cincinnati Reds | Free agent signing |
| Jan 6, 2010 | Signed as free agent | Matt Capps | — | Washington Nationals | Free agent signing |
| Jan 6, 2010 | Signed as free agent | Luke Carlin | — | Pittsburgh Pirates | Free agent signing |
| Jan 6, 2010 | Signed as free agent | Clay Condrey | — | Minnesota Twins | Free agent signing |
| Jan 6, 2010 | Signed as free agent | Chad Cordero | — | Seattle Mariners | Free agent signing |
| Jan 6, 2010 | Signed as free agent | Sergio Mitre | — | New York Yankees | Free agent signing |
| Jan 6, 2010 | Signed as free agent | Dane Sardinha | — | Philadelphia Phillies | Free agent signing |
| Jan 6, 2010 | Signed as free agent | Joe Thurston | — | Atlanta Braves | Free agent signing |
| Jan 6, 2010 | Signed as free agent | Ryan Vogelsong | — | Philadelphia Phillies | Free agent signing |
| Jan 6, 2010 | Signed as free agent | Ehren Wassermann | — | Philadelphia Phillies | Free agent signing |
| Jan 6, 2010 | Signed as free agent | Chris Woodward | — | Seattle Mariners | Free agent signing |
| Jan 5, 2010 | Signed as free agent | Josh Bard | — | Seattle Mariners | Free agent signing |
| Jan 5, 2010 | Signed as free agent | Callix Crabbe | — | Toronto Blue Jays | Free agent signing |
| Jan 5, 2010 | Signed as free agent | Troy Glaus | — | Atlanta Braves | Free agent signing |
| Jan 5, 2010 | Signed as free agent | Eric Hinske | — | Atlanta Braves | Free agent signing |
| Jan 5, 2010 | Signed as free agent | Matt Holliday | — | St. Louis Cardinals | Free agent signing |
| Jan 5, 2010 | Released | Bobby Keppel | Minnesota Twins | — | Release |
| Jan 5, 2010 | Signed as free agent | Royce Ring | — | New York Yankees | Free agent signing |
| Jan 5, 2010 | Signed as free agent | Zack Segovia | — | New York Yankees | Free agent signing |
| Jan 5, 2010 | Released | Tony Barnette | Arizona Diamondbacks | — | Release |
| Jan 4, 2010 | Signed as free agent | Adrian Beltre | — | Boston Red Sox | Free agent signing |
| Jan 4, 2010 | Signed as free agent | Evan MacLane | — | St. Louis Cardinals | Free agent signing |
| Jan 4, 2010 | Signed as free agent | Osiris Matos | — | San Francisco Giants | Free agent signing |
| Jan 4, 2010 | Signed as free agent | Miguel Olivo | — | Colorado Rockies | Free agent signing |
| Jan 4, 2010 | Signed as free agent | John Parrish | — | Kansas City Royals | Free agent signing |
| Jan 4, 2010 | Signed as free agent | Brian Shouse | — | Boston Red Sox | Free agent signing |
| Jan 4, 2010 | Signed as free agent | Juan Uribe | — | San Francisco Giants | Free agent signing |
| Jan 2, 2010 | Signed as free agent | Santiago Casilla | — | San Francisco Giants | Free agent signing |
Every row is mapped onto the same trade / signing / release vocabulary the modern feed uses, with the era’s own type description kept on each row. Club names are the names of the day (the Boston Braves years, the Brooklyn Dodgers years), and each links to the franchise it is today. Some dates are only partially known or flagged approximate by the source; they are shown exactly as published, never completed to a fake precise day.