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The 2000 season’s official transaction log: 1,093 trades, signings and releases involving major-league clubs, listed newest first.
| Date | Type | Player | From | To | Details |
|---|---|---|---|---|---|
| Dec 28, 2000 | Signed | Roberto Hernandez | — | Cleveland Indians | Amateur free agent signing |
| Dec 28, 2000 | Signed as free agent | Mark Johnson | — | New York Mets | Free agent signing |
| Dec 28, 2000 | Signed as free agent | Joe Roa | — | Florida Marlins | Free agent signing |
| Dec 28, 2000 | Signed as free agent | Mike Romano | — | Atlanta Braves | Free agent signing |
| Dec 27, 2000 | Signed as free agent | Marty Malloy | — | Cincinnati Reds | Free agent signing |
| Dec 27, 2000 | Signed as free agent | Jason Ryan | — | Pittsburgh Pirates | Free agent signing |
| Dec 26, 2000 | Signed as free agent | Pete Walker | — | New York Mets | Free agent signing |
| Dec 24, 2000 | Signed as free agent | Jeff D'Amico | — | Kansas City Royals | Free agent signing |
| Dec 23, 2000 | Signed as free agent | Oscar Henriquez | — | New York Mets | Free agent signing |
| Dec 23, 2000 | Signed as free agent | Yorkis Perez | — | Los Angeles Dodgers | Free agent signing |
| Dec 22, 2000 | Signed as free agent | Bret Boone | — | Seattle Mariners | Free agent signing |
| Dec 22, 2000 | Signed as free agent | Karim Garcia | — | Cleveland Indians | Free agent signing |
| Dec 22, 2000 | Signed as free agent | Jeffrey Hammonds | — | Milwaukee Brewers | Free agent signing |
| Dec 22, 2000 | Signed as free agent | Tom Lampkin | — | Seattle Mariners | Free agent signing |
| Dec 22, 2000 | Signed as free agent | Quinton McCracken | — | St. Louis Cardinals | Free agent signing |
| Dec 22, 2000 | Signed as free agent | Peter Munro | — | Texas Rangers | Free agent signing |
| Dec 22, 2000 | Signed as free agent | Brian Shouse | — | Houston Astros | Free agent signing |
| Dec 22, 2000 | Signed as free agent | Kevin Witt | — | San Diego Padres | Free agent signing |
| Dec 22, 2000 | Trade | Ryan Minor | Baltimore Orioles | Montreal Expos | Trade |
| Dec 22, 2000 | Trade | Jorge Julio | Montreal Expos | Baltimore Orioles | Trade |
| Dec 21, 2000 | Signed as free agent | Raul Gonzalez | — | Cincinnati Reds | Free agent signing |
| Dec 21, 2000 | Signed as free agent | Trent Hubbard | — | Toronto Blue Jays | Free agent signing |
| Dec 21, 2000 | Signed as free agent | Robin Jennings | — | Oakland Athletics | Free agent signing |
| Dec 21, 2000 | Signed as free agent | Brian Johnson | — | Los Angeles Dodgers | Free agent signing |
| Dec 21, 2000 | Signed as free agent | Curtis Pride | — | Montreal Expos | Free agent signing |
| Dec 21, 2000 | Signed as free agent | Tim Raines | — | Montreal Expos | Free agent signing |
| Dec 21, 2000 | Signed as free agent | Bob Scanlan | — | Montreal Expos | Free agent signing |
| Dec 21, 2000 | Signed as free agent | David Segui | — | Baltimore Orioles | Free agent signing |
| Dec 21, 2000 | Signed as free agent | Aaron Small | — | Anaheim Angels | Free agent signing |
| Dec 20, 2000 | Signed as free agent | Scott Aldred | — | Cleveland Indians | Free agent signing |
| Dec 20, 2000 | Signed as free agent | Rigo Beltran | — | Philadelphia Phillies | Free agent signing |
| Dec 20, 2000 | Signed as free agent | Mike Bordick | — | Baltimore Orioles | Free agent signing |
| Dec 20, 2000 | Signed as free agent | Micah Bowie | — | Oakland Athletics | Free agent signing |
| Dec 20, 2000 | Signed as free agent | John Burkett | — | Atlanta Braves | Free agent signing |
| Dec 20, 2000 | Signed as free agent | Marty Cordova | — | Cleveland Indians | Free agent signing |
| Dec 20, 2000 | Signed as free agent | Eric Gunderson | — | Cleveland Indians | Free agent signing |
| Dec 20, 2000 | Signed as free agent | Dave Hollins | — | Cleveland Indians | Free agent signing |
| Dec 20, 2000 | Signed as free agent | Tim Laker | — | Cleveland Indians | Free agent signing |
| Dec 20, 2000 | Signed as free agent | Brian Lesher | — | Milwaukee Brewers | Free agent signing |
| Dec 20, 2000 | Released | Mike Lincoln | Minnesota Twins | — | Release |
| Dec 20, 2000 | Released | Frankie Rodriguez | Seattle Mariners | — | Release |
| Dec 20, 2000 | Signed as free agent | Clint Sodowsky | — | Philadelphia Phillies | Free agent signing |
| Dec 20, 2000 | Signed as free agent | Rob Stanifer | — | Chicago Cubs | Free agent signing |
| Dec 20, 2000 | Signed as free agent | Ed Vosberg | — | Philadelphia Phillies | Free agent signing |
| Dec 20, 2000 | Signed as free agent | Turner Ward | — | Philadelphia Phillies | Free agent signing |
| Dec 20, 2000 | Trade | Justin Carter | Colorado Rockies | Cincinnati Reds | Trade |
| Dec 20, 2000 | Trade | Jeff Taglienti | Colorado Rockies | Cincinnati Reds | Trade |
| Dec 20, 2000 | Trade | Chad Green | Milwaukee Brewers | San Diego Padres | Trade |
| Dec 20, 2000 | Trade | Will Cunnane | San Diego Padres | Milwaukee Brewers | Trade |
| Dec 19, 2000 | Signed as free agent | Norm Charlton | — | Seattle Mariners | Free agent signing |
| Dec 19, 2000 | Released | Brian Falkenborg | Baltimore Orioles | — | Release |
| Dec 19, 2000 | Signed as free agent | Pat Hentgen | — | Baltimore Orioles | Free agent signing |
| Dec 19, 2000 | Signed as free agent | Todd Hundley | — | Chicago Cubs | Free agent signing |
| Dec 19, 2000 | Signed as free agent | Izzy Molina | — | Toronto Blue Jays | Free agent signing |
| Dec 19, 2000 | Signed as free agent | Tom Prince | — | Minnesota Twins | Free agent signing |
| Dec 19, 2000 | Signed as free agent | Manny Ramirez | — | Boston Red Sox | Free agent signing |
| Dec 18, 2000 | Signed as free agent | Sandy Alomar | — | Chicago White Sox | Free agent signing |
| Dec 18, 2000 | Signed as free agent | Jason Bere | — | Chicago Cubs | Free agent signing |
| Dec 18, 2000 | Signed as free agent | Jeff Branson | — | Los Angeles Dodgers | Free agent signing |
| Dec 18, 2000 | Signed as free agent | Charles Johnson | — | Florida Marlins | Free agent signing |
| Dec 18, 2000 | Signed as free agent | Allen McDill | — | Boston Red Sox | Free agent signing |
| Dec 18, 2000 | Signed as free agent | Jon Nunnally | — | Kansas City Royals | Free agent signing |
| Dec 18, 2000 | Signed as free agent | Chris Tremie | — | Houston Astros | Free agent signing |
| Dec 18, 2000 | Trade | Jesse Garcia | Baltimore Orioles | Atlanta Braves | Trade |
| Dec 18, 2000 | Trade | Steve Sisco | Atlanta Braves | Baltimore Orioles | Trade |
| Dec 17, 2000 | Signed as free agent | Alberto Castillo | — | Tampa Bay Devil Rays | Free agent signing |
| Dec 15, 2000 | Signed as free agent | Ricky Bottalico | — | Philadelphia Phillies | Free agent signing |
| Dec 15, 2000 | Signed as free agent | Chris Clapinski | — | Florida Marlins | Free agent signing |
| Dec 15, 2000 | Signed as free agent | Midre Cummings | — | Arizona Diamondbacks | Free agent signing |
| Dec 15, 2000 | Released | Miguel Del Toro | San Francisco Giants | — | Release |
| Dec 15, 2000 | Signed as free agent | Trent Durrington | — | Los Angeles Dodgers | Free agent signing |
| Dec 15, 2000 | Signed as free agent | Jared Fernandez | — | Cincinnati Reds | Free agent signing |
| Dec 15, 2000 | Signed | Victor Marte | — | Kansas City Royals | Amateur free agent signing |
| Dec 15, 2000 | Signed as free agent | Bobby Munoz | — | Montreal Expos | Free agent signing |
| Dec 15, 2000 | Signed as free agent | Hideo Nomo | — | Boston Red Sox | Free agent signing |
| Dec 15, 2000 | Signed as free agent | Adam Riggs | — | San Diego Padres | Free agent signing |
| Dec 15, 2000 | Signed as free agent | Bill Selby | — | Cincinnati Reds | Free agent signing |
| Dec 15, 2000 | Signed as free agent | Scott Service | — | Los Angeles Dodgers | Free agent signing |
| Dec 15, 2000 | Signed as free agent | Jon Shave | — | Boston Red Sox | Free agent signing |
| Dec 15, 2000 | Signed as free agent | Ryan Thompson | — | Toronto Blue Jays | Free agent signing |
| Dec 15, 2000 | Released | Marc Wilkins | Oakland Athletics | — | Release |
| Dec 15, 2000 | Signed as free agent | Mark Wohlers | — | Cincinnati Reds | Free agent signing |
| Dec 15, 2000 | Trade | Brandon Villafuerte | Detroit Tigers | Texas Rangers | Trade |
| Dec 15, 2000 | Trade | Kevin Mobley | Detroit Tigers | Texas Rangers | Trade |
| Dec 15, 2000 | Trade | Matt Perisho | Texas Rangers | Detroit Tigers | Trade |
| Dec 14, 2000 | Signed as free agent | Brian Boehringer | — | New York Yankees | Free agent signing |
| Dec 14, 2000 | Signed as free agent | Tom Gordon | — | Chicago Cubs | Free agent signing |
| Dec 14, 2000 | Signed | J. C. Gutierrez | — | Houston Astros | Amateur free agent signing |
| Dec 14, 2000 | Signed as free agent | Michael Jackson | — | Houston Astros | Free agent signing |
| Dec 14, 2000 | Signed as free agent | Jim Morris | — | Los Angeles Dodgers | Free agent signing |
| Dec 14, 2000 | Signed as free agent | Steve Trachsel | — | New York Mets | Free agent signing |
| Dec 14, 2000 | Signed as free agent | Matt Whisenant | — | Los Angeles Dodgers | Free agent signing |
| Dec 14, 2000 | Trade | Aaron Myette | Chicago White Sox | Texas Rangers | Trade |
| Dec 14, 2000 | Trade | Brian Schmack | Chicago White Sox | Texas Rangers | Trade |
| Dec 14, 2000 | Trade | Royce Clayton | Texas Rangers | Chicago White Sox | Trade |
| Dec 14, 2000 | Trade | Britt Reames | St. Louis Cardinals | Montreal Expos | Trade |
| Dec 14, 2000 | Trade | Fernando Tatis | St. Louis Cardinals | Montreal Expos | Trade |
| Dec 14, 2000 | Trade | Dustin Hermanson | Montreal Expos | St. Louis Cardinals | Trade |
| Dec 14, 2000 | Trade | Steve Kline | Montreal Expos | St. Louis Cardinals | Trade |
| Dec 13, 2000 | Signed as free agent | Alex Arias | — | San Diego Padres | Free agent signing |
| Dec 13, 2000 | Signed as free agent | Rafael Betancourt | — | Boston Red Sox | Free agent signing |
| Dec 13, 2000 | Signed as free agent | Rico Brogna | — | Atlanta Braves | Free agent signing |
| Dec 13, 2000 | Signed as free agent | Scott Forster | — | New York Mets | Free agent signing |
| Dec 13, 2000 | Signed as free agent | Kevin Foster | — | Texas Rangers | Free agent signing |
| Dec 13, 2000 | Signed as free agent | Scarborough Green | — | Chicago Cubs | Free agent signing |
| Dec 13, 2000 | Signed as free agent | Robert Machado | — | Chicago Cubs | Free agent signing |
| Dec 13, 2000 | Signed as free agent | Chris Michalak | — | Toronto Blue Jays | Free agent signing |
| Dec 13, 2000 | Signed as free agent | Mike Munoz | — | Texas Rangers | Free agent signing |
| Dec 13, 2000 | Signed as free agent | Jaime Navarro | — | Toronto Blue Jays | Free agent signing |
| Dec 13, 2000 | Signed as free agent | Dave Wainhouse | — | Chicago Cubs | Free agent signing |
| Dec 13, 2000 | Trade | Miguel Olivo | Oakland Athletics | Chicago White Sox | Trade |
| Dec 12, 2000 | Signed as free agent | Mike Hampton | — | Colorado Rockies | Free agent signing |
| Dec 12, 2000 | Signed as free agent | Phil Hiatt | — | Los Angeles Dodgers | Free agent signing |
| Dec 12, 2000 | Signed as free agent | Kevin Orie | — | Philadelphia Phillies | Free agent signing |
| Dec 12, 2000 | Signed as free agent | Ruben Sierra | — | Texas Rangers | Free agent signing |
| Dec 11, 2000 | Signed as free agent | Kevin Appier | — | New York Mets | Free agent signing |
| Dec 11, 2000 | Signed as free agent | Kimera Bartee | — | Anaheim Angels | Free agent signing |
| Dec 11, 2000 | Signed as free agent | Joe Borowski | — | Chicago Cubs | Free agent signing |
| Dec 11, 2000 | Signed as free agent | Darren Dreifort | — | Los Angeles Dodgers | Free agent signing |
| Dec 11, 2000 | Signed as free agent | Jeff Frye | — | Toronto Blue Jays | Free agent signing |
| Dec 11, 2000 | Signed as free agent | Doug Henry | — | Kansas City Royals | Free agent signing |
| Dec 11, 2000 | Signed as free agent | Pat Rapp | — | Anaheim Angels | Free agent signing |
| Dec 11, 2000 | Trade | Mark Roberts | Chicago White Sox | Florida Marlins | Trade |
| Dec 11, 2000 | Trade | John Bale | Toronto Blue Jays | Baltimore Orioles | Trade |
| Dec 11, 2000 | Trade | Jayson Werth | Baltimore Orioles | Toronto Blue Jays | Trade |
| Dec 11, 2000 | Trade | Brad Ausmus | Detroit Tigers | Houston Astros | Trade |
| Dec 11, 2000 | Trade | Doug Brocail | Detroit Tigers | Houston Astros | Trade |
| Dec 11, 2000 | Trade | Nelson Cruz | Detroit Tigers | Houston Astros | Trade |
| Dec 11, 2000 | Trade | Roger Cedeno | Houston Astros | Detroit Tigers | Trade |
| Dec 11, 2000 | Trade | Chris Holt | Houston Astros | Detroit Tigers | Trade |
| Dec 11, 2000 | Trade | Mitch Meluskey | Houston Astros | Detroit Tigers | Trade |
| Dec 11, 2000 | Trade | Bubba Trammell | New York Mets | San Diego Padres | Trade |
| Dec 11, 2000 | Trade | Donne Wall | San Diego Padres | New York Mets | Trade |
| Dec 10, 2000 | Signed as free agent | Derek Bell | — | Pittsburgh Pirates | Free agent signing |
| Dec 10, 2000 | Signed as free agent | Ken Caminiti | — | Texas Rangers | Free agent signing |
| Dec 10, 2000 | Signed as free agent | Ron Gant | — | Colorado Rockies | Free agent signing |
| Dec 10, 2000 | Signed as free agent | Alex Gonzalez | — | Toronto Blue Jays | Free agent signing |
| Dec 10, 2000 | Signed as free agent | Dave Martinez | — | Atlanta Braves | Free agent signing |
| Dec 10, 2000 | Signed as free agent | Terry Mulholland | — | Pittsburgh Pirates | Free agent signing |
| Dec 10, 2000 | Signed as free agent | Mark Petkovsek | — | Texas Rangers | Free agent signing |
| Dec 10, 2000 | Released | Jason Ryan | Minnesota Twins | — | Release |
| Dec 10, 2000 | Signed as free agent | Ernie Young | — | San Diego Padres | Free agent signing |
| Dec 9, 2000 | Trade | Seth Etherton | Anaheim Angels | Cincinnati Reds | Trade |
| Dec 9, 2000 | Trade | Wilmy Caceres | Cincinnati Reds | Anaheim Angels | Trade |
| Dec 9, 2000 | Trade | Jeff Abbott | Chicago White Sox | Florida Marlins | Trade |
| Dec 9, 2000 | Trade | Julio Ramirez | Florida Marlins | Chicago White Sox | Trade |
| Dec 8, 2000 | Signed as free agent | Bubba Carpenter | — | New York Mets | Free agent signing |
| Dec 8, 2000 | Signed as free agent | Shawon Dunston | — | San Francisco Giants | Free agent signing |
| Dec 8, 2000 | Signed as free agent | Jeff Fassero | — | Chicago Cubs | Free agent signing |
| Dec 8, 2000 | Signed as free agent | Andres Galarraga | — | Texas Rangers | Free agent signing |
| Dec 8, 2000 | Signed as free agent | Mark Grace | — | Arizona Diamondbacks | Free agent signing |
| Dec 8, 2000 | Signed as free agent | Dan Plesac | — | Toronto Blue Jays | Free agent signing |
| Dec 8, 2000 | Signed as free agent | Nerio Rodriguez | — | New York Mets | Free agent signing |
| Dec 7, 2000 | Signed as free agent | Tim Belcher | — | Anaheim Angels | Free agent signing |
| Dec 7, 2000 | Signed as free agent | Jay Buhner | — | Seattle Mariners | Free agent signing |
| Dec 7, 2000 | Signed as free agent | Frank Castillo | — | Boston Red Sox | Free agent signing |
| Dec 7, 2000 | Signed as free agent | Jason Dickson | — | Toronto Blue Jays | Free agent signing |
| Dec 7, 2000 | Signed as free agent | Cal Eldred | — | Chicago White Sox | Free agent signing |
| Dec 7, 2000 | Signed as free agent | Mark Gardner | — | San Francisco Giants | Free agent signing |
| Dec 7, 2000 | Signed as free agent | Dwight Gooden | — | New York Yankees | Free agent signing |
| Dec 7, 2000 | Signed as free agent | Tony Gwynn | — | San Diego Padres | Free agent signing |
| Dec 7, 2000 | Signed as free agent | Jason Jacome | — | Arizona Diamondbacks | Free agent signing |
| Dec 7, 2000 | Signed as free agent | James Mouton | — | Milwaukee Brewers | Free agent signing |
| Dec 7, 2000 | Signed as free agent | Mike Mussina | — | New York Yankees | Free agent signing |
| Dec 7, 2000 | Signed as free agent | Kerry Robinson | — | St. Louis Cardinals | Free agent signing |
| Dec 7, 2000 | Signed as free agent | Pete Schourek | — | Boston Red Sox | Free agent signing |
| Dec 7, 2000 | Signed as free agent | Luis Sojo | — | New York Yankees | Free agent signing |
| Dec 7, 2000 | Signed as free agent | Ed Sprague | — | San Diego Padres | Free agent signing |
| Dec 7, 2000 | Signed as free agent | Tim Wakefield | — | Boston Red Sox | Free agent signing |
| Dec 7, 2000 | Trade | Chad Bradford | Chicago White Sox | Oakland Athletics | Trade |
| Dec 6, 2000 | Signed as free agent | Andy Ashby | — | Los Angeles Dodgers | Free agent signing |
| Dec 6, 2000 | Signed as free agent | Gary Disarcina | — | Anaheim Angels | Free agent signing |
| Dec 6, 2000 | Signed as free agent | Dave Eiland | — | Oakland Athletics | Free agent signing |
| Dec 6, 2000 | Signed as free agent | Ozzie Guillen | — | Tampa Bay Devil Rays | Free agent signing |
| Dec 6, 2000 | Signed as free agent | Erik Hiljus | — | Oakland Athletics | Free agent signing |
| Dec 6, 2000 | Signed as free agent | Mickey Morandini | — | Toronto Blue Jays | Free agent signing |
| Dec 6, 2000 | Signed as free agent | Rick Reed | — | New York Mets | Free agent signing |
| Dec 6, 2000 | Signed as free agent | Armando Reynoso | — | Arizona Diamondbacks | Free agent signing |
| Dec 6, 2000 | Signed as free agent | Steve Schrenk | — | Oakland Athletics | Free agent signing |
| Dec 6, 2000 | Signed as free agent | Turk Wendell | — | New York Mets | Free agent signing |
| Dec 5, 2000 | Signed as free agent | Brett Hinchliffe | — | New York Mets | Free agent signing |
| Dec 5, 2000 | Signed as free agent | Randall Simon | — | Detroit Tigers | Free agent signing |
| Dec 4, 2000 | Signed as free agent | Denny Neagle | — | Colorado Rockies | Free agent signing |
| Dec 4, 2000 | Signed as free agent | Jeff Nelson | — | Seattle Mariners | Free agent signing |
| Dec 2, 2000 | Signed as free agent | Derrin Ebert | — | Tampa Bay Devil Rays | Free agent signing |
| Dec 2, 2000 | Signed as free agent | Tim Harikkala | — | Milwaukee Brewers | Free agent signing |
| Dec 2, 2000 | Signed as free agent | Chris Latham | — | Toronto Blue Jays | Free agent signing |
| Dec 1, 2000 | Released | Kimera Bartee | Cincinnati Reds | — | Release |
| Dec 1, 2000 | Signed as free agent | Scott Karl | — | San Diego Padres | Free agent signing |
| Dec 1, 2000 | Signed as free agent | Brooks Kieschnick | — | Colorado Rockies | Free agent signing |
| Dec 1, 2000 | Signed as free agent | Juan Moreno | — | Texas Rangers | Free agent signing |
| Dec 1, 2000 | Signed as free agent | Kevin Pickford | — | Pittsburgh Pirates | Free agent signing |
| Dec 1, 2000 | Trade | Santiago Perez | Milwaukee Brewers | San Diego Padres | Trade |
| Dec 1, 2000 | Trade | Brandon Kolb | San Diego Padres | Milwaukee Brewers | Trade |
| Nov 30, 2000 | Signed as free agent | Rheal Cormier | — | Philadelphia Phillies | Free agent signing |
| Nov 30, 2000 | Signed as free agent | Charlie Greene | — | San Diego Padres | Free agent signing |
| Nov 30, 2000 | Signed as free agent | Matt Skrmetta | — | Cincinnati Reds | Free agent signing |
| Nov 30, 2000 | Signed as free agent | Jose Valentin | — | Chicago White Sox | Free agent signing |
| Nov 29, 2000 | Released | Mark Brownson | Philadelphia Phillies | — | Release |
| Nov 29, 2000 | Signed as free agent | Brian Hunter | — | Philadelphia Phillies | Free agent signing |
| Nov 29, 2000 | Signed as free agent | Tommy Phelps | — | Detroit Tigers | Free agent signing |
| Nov 27, 2000 | Signed as free agent | Toby Borland | — | Anaheim Angels | Free agent signing |
| Nov 27, 2000 | Released | Micah Bowie | Chicago Cubs | — | Release |
| Nov 27, 2000 | Released | Miguel Cairo | Tampa Bay Devil Rays | — | Release |
| Nov 27, 2000 | Released | Erik Hiljus | Detroit Tigers | — | Release |
| Nov 27, 2000 | Released | Brian Hunter | Cincinnati Reds | — | Release |
| Nov 27, 2000 | Signed as free agent | Pascual Matos | — | New York Yankees | Free agent signing |
| Nov 27, 2000 | Released | Quinton McCracken | Tampa Bay Devil Rays | — | Release |
| Nov 27, 2000 | Released | Jose Molina | Chicago Cubs | — | Release |
| Nov 27, 2000 | Released | Jim Morris | Tampa Bay Devil Rays | — | Release |
| Nov 27, 2000 | Released | Lyle Mouton | Milwaukee Brewers | — | Release |
| Nov 27, 2000 | Released | Jeff Sparks | Tampa Bay Devil Rays | — | Release |
| Nov 27, 2000 | Released | Jerry Spradlin | Chicago Cubs | — | Release |
| Nov 27, 2000 | Trade | Amaury Garcia | Florida Marlins | Chicago White Sox | Trade |
| Nov 26, 2000 | Signed as free agent | Rick Short | — | Chicago Cubs | Free agent signing |
| Nov 25, 2000 | Signed as free agent | John Franco | — | New York Mets | Free agent signing |
| Nov 25, 2000 | Signed as free agent | Eric Knott | — | Arizona Diamondbacks | Free agent signing |
| Nov 22, 2000 | Signed as free agent | Ray Holbert | — | Tampa Bay Devil Rays | Free agent signing |
| Nov 22, 2000 | Signed as free agent | Mike Metcalfe | — | Tampa Bay Devil Rays | Free agent signing |
| Nov 22, 2000 | Signed as free agent | Jim Rushford | — | Milwaukee Brewers | Free agent signing with first major-league team |
| Nov 22, 2000 | Signed as free agent | Craig Wilson | — | Kansas City Royals | Free agent signing |
| Nov 22, 2000 | Trade | Clayton Andrews | Toronto Blue Jays | Cincinnati Reds | Trade |
| Nov 22, 2000 | Trade | Leo Estrella | Toronto Blue Jays | Cincinnati Reds | Trade |
| Nov 22, 2000 | Trade | Steve Parris | Cincinnati Reds | Toronto Blue Jays | Trade |
| Nov 21, 2000 | Signed as free agent | Alejandro Freire | — | Detroit Tigers | Free agent signing |
| Nov 21, 2000 | Signed as free agent | Jose Mesa | — | Philadelphia Phillies | Free agent signing |
| Nov 21, 2000 | Signed as free agent | Joe Oliver | — | New York Yankees | Free agent signing |
| Nov 21, 2000 | Signed as free agent | Jarrod Patterson | — | Detroit Tigers | Free agent signing |
| Nov 20, 2000 | Signed as free agent | Bryan Corey | — | San Diego Padres | Free agent signing |
| Nov 20, 2000 | Signed as free agent | Jorge Fabregas | — | Anaheim Angels | Free agent signing |
| Nov 20, 2000 | Released | Jason Green | Colorado Rockies | — | Release |
| Nov 20, 2000 | Released | Jason Grimsley | New York Yankees | — | Release |
| Nov 20, 2000 | Signed as free agent | Domingo Guzman | — | San Diego Padres | Free agent signing |
| Nov 20, 2000 | Signed as free agent | Keith Luuloa | — | San Diego Padres | Free agent signing |
| Nov 20, 2000 | Signed as free agent | Ron Mahay | — | San Diego Padres | Free agent signing |
| Nov 20, 2000 | Signed as free agent | David Moraga | — | Colorado Rockies | Free agent signing |
| Nov 20, 2000 | Signed as free agent | Jake Robbins | — | Atlanta Braves | Free agent signing |
| Nov 20, 2000 | Signed as free agent | Jose Vizcaino | — | Houston Astros | Free agent signing |
| Nov 20, 2000 | Trade | Matt Stairs | Oakland Athletics | Chicago Cubs | Trade |
| Nov 20, 2000 | Trade | Eric Ireland | Chicago Cubs | Oakland Athletics | Trade |
| Nov 19, 2000 | Signed as free agent | Ellis Burks | — | Cleveland Indians | Free agent signing |
| Nov 19, 2000 | Signed | Robinzon Diaz | — | Toronto Blue Jays | Amateur free agent signing |
| Nov 19, 2000 | Signed | Ryan Rowland-Smith | — | Seattle Mariners | Amateur free agent signing |
| Nov 18, 2000 | Signed | Franklin Gutierrez | — | Los Angeles Dodgers | Amateur free agent signing |
| Nov 18, 2000 | Signed as free agent | Juan Melo | — | San Francisco Giants | Free agent signing |
| Nov 18, 2000 | Signed as free agent | Dan Smith | — | Cleveland Indians | Free agent signing |
| Nov 18, 2000 | Trade | Bill Mueller | San Francisco Giants | Chicago Cubs | Trade |
| Nov 18, 2000 | Trade | Tim Worrell | Chicago Cubs | San Francisco Giants | Trade |
| Nov 17, 2000 | Signed as free agent | Andy Abad | — | Oakland Athletics | Free agent signing |
| Nov 17, 2000 | Signed as free agent | Jason Beverlin | — | Anaheim Angels | Free agent signing |
| Nov 17, 2000 | Released | Ben Ford | Chicago Cubs | — | Release |
| Nov 17, 2000 | Released | Scarborough Green | Texas Rangers | — | Release |
| Nov 17, 2000 | Signed as free agent | Hansel Izquierdo | — | Florida Marlins | Free agent signing |
| Nov 17, 2000 | Signed as free agent | Ryan Jackson | — | Detroit Tigers | Free agent signing |
| Nov 17, 2000 | Signed as free agent | Randy Knorr | — | Montreal Expos | Free agent signing |
| Nov 17, 2000 | Signed as free agent | Felipe Lira | — | Montreal Expos | Free agent signing |
| Nov 17, 2000 | Signed as free agent | Sandy Martinez | — | Montreal Expos | Free agent signing |
| Nov 17, 2000 | Signed as free agent | Carlos Mendez | — | Detroit Tigers | Free agent signing |
| Nov 17, 2000 | Signed as free agent | Mark Smith | — | Montreal Expos | Free agent signing |
| Nov 17, 2000 | Trade | Ryan Cullen | Texas Rangers | Oakland Athletics | Trade |
| Nov 17, 2000 | Trade | Aaron Harang | Texas Rangers | Oakland Athletics | Trade |
| Nov 17, 2000 | Trade | Randy Velarde | Oakland Athletics | Texas Rangers | Trade |
| Nov 16, 2000 | Signed as free agent | Sean Bergman | — | Tampa Bay Devil Rays | Free agent signing |
| Nov 16, 2000 | Signed as free agent | Jim Crowell | — | St. Louis Cardinals | Free agent signing |
| Nov 16, 2000 | Signed as free agent | Todd Hollandsworth | — | Colorado Rockies | Free agent signing |
| Nov 16, 2000 | Signed as free agent | Jesse Levis | — | Atlanta Braves | Free agent signing |
| Nov 16, 2000 | Signed as free agent | Damaso Marte | — | New York Yankees | Free agent signing |
| Nov 16, 2000 | Signed as free agent | Paul O'Neill | — | New York Yankees | Free agent signing |
| Nov 16, 2000 | Signed as free agent | Robert Perez | — | New York Yankees | Free agent signing |
| Nov 16, 2000 | Signed as free agent | Willis Roberts | — | Baltimore Orioles | Free agent signing |
| Nov 16, 2000 | Signed as free agent | Julian Tavarez | — | Chicago Cubs | Free agent signing |
| Nov 16, 2000 | Released | Todd Williams | Seattle Mariners | — | Release |
| Nov 16, 2000 | Trade | Jim Brower | Cleveland Indians | Cincinnati Reds | Trade |
| Nov 16, 2000 | Trade | Rob Pugmire | Cleveland Indians | Cincinnati Reds | Trade |
| Nov 16, 2000 | Trade | Ed Taubensee | Cincinnati Reds | Cleveland Indians | Trade |
| Nov 16, 2000 | Trade | Michael Coleman | Boston Red Sox | Cincinnati Reds | Trade |
| Nov 16, 2000 | Trade | Donnie Sadler | Boston Red Sox | Cincinnati Reds | Trade |
| Nov 16, 2000 | Trade | Chris Stynes | Cincinnati Reds | Boston Red Sox | Trade |
| Nov 15, 2000 | Signed as free agent | Mark Dalesandro | — | Chicago White Sox | Free agent signing |
| Nov 15, 2000 | Signed as free agent | P. J. Forbes | — | Philadelphia Phillies | Free agent signing |
| Nov 15, 2000 | Signed as free agent | Micah Franklin | — | Milwaukee Brewers | Free agent signing |
| Nov 15, 2000 | Signed as free agent | Eddie Oropesa | — | Philadelphia Phillies | Free agent signing |
| Nov 15, 2000 | Signed | Miguel Perez | — | Cincinnati Reds | Amateur free agent signing |
| Nov 15, 2000 | Released | Johnny Ruffin | Arizona Diamondbacks | — | Release |
| Nov 15, 2000 | Signed as free agent | Andy Sheets | — | Tampa Bay Devil Rays | Free agent signing |
| Nov 15, 2000 | Released | J. D. Smart | Montreal Expos | — | Release |
| Nov 15, 2000 | Released | Ryan Thompson | New York Yankees | — | Release |
| Nov 15, 2000 | Signed as free agent | Yohanny Valera | — | Tampa Bay Devil Rays | Free agent signing |
| Nov 14, 2000 | Signed | Ambiorix Burgos | — | Kansas City Royals | Amateur free agent signing |
| Nov 14, 2000 | Released | Juan Melo | San Francisco Giants | — | Release |
| Nov 13, 2000 | Signed as free agent | Mike Coolbaugh | — | Milwaukee Brewers | Free agent signing |
| Nov 13, 2000 | Signed as free agent | Trace Coquillette | — | Chicago Cubs | Free agent signing |
| Nov 13, 2000 | Signed as free agent | Matt Treanor | — | Florida Marlins | Free agent signing |
| Nov 13, 2000 | Released | Pete Walker | Colorado Rockies | — | Release |
| Nov 12, 2000 | Signed as free agent | Keith Johnson | — | Los Angeles Dodgers | Free agent signing |
| Nov 12, 2000 | Signed as free agent | Scott Stewart | — | Montreal Expos | Free agent signing |
| Nov 11, 2000 | Signed as free agent | Mandy Romero | — | Florida Marlins | Free agent signing |
| Nov 10, 2000 | Signed as free agent | Brian Banks | — | Chicago Cubs | Free agent signing |
| Nov 10, 2000 | Signed as free agent | Jayson Durocher | — | Texas Rangers | Free agent signing |
| Nov 10, 2000 | Signed as free agent | Julio Santana | — | San Francisco Giants | Free agent signing |
| Nov 10, 2000 | Signed as free agent | Rob Sasser | — | Montreal Expos | Free agent signing |
| Nov 9, 2000 | Signed as free agent | Jeff Barry | — | Los Angeles Dodgers | Free agent signing |
| Nov 9, 2000 | Signed as free agent | Ricky Bones | — | Florida Marlins | Free agent signing |
| Nov 9, 2000 | Signed as free agent | Chan Perry | — | Atlanta Braves | Free agent signing |
| Nov 9, 2000 | Signed as free agent | Paul Spoljaric | — | Tampa Bay Devil Rays | Free agent signing |
| Nov 9, 2000 | Signed as free agent | Ron Wright | — | Tampa Bay Devil Rays | Free agent signing |
| Nov 8, 2000 | Signed as free agent | Ken Cloude | — | Seattle Mariners | Free agent signing |
| Nov 8, 2000 | Signed as free agent | Joe Davenport | — | Colorado Rockies | Free agent signing |
| Nov 8, 2000 | Signed as free agent | David Lamb | — | Anaheim Angels | Free agent signing |
| Nov 8, 2000 | Trade | Ron Villone | Cincinnati Reds | Colorado Rockies | Trade |
| Nov 7, 2000 | Signed as free agent | Derrick Gibson | — | Tampa Bay Devil Rays | Free agent signing |
| Nov 7, 2000 | Signed as free agent | Mark Little | — | Colorado Rockies | Free agent signing |
| Nov 7, 2000 | Signed as free agent | Scott Podsednik | — | Seattle Mariners | Free agent signing |
| Nov 7, 2000 | Signed as free agent | Ricky Stone | — | Houston Astros | Free agent signing |
| Nov 7, 2000 | Released | Craig Wilson | Chicago White Sox | — | Release |
| Nov 7, 2000 | Signed as free agent | Tom Wilson | — | Oakland Athletics | Free agent signing |
| Nov 7, 2000 | Trade | Gary Glover | Toronto Blue Jays | Chicago White Sox | Trade |
| Nov 7, 2000 | Trade | Scott Eyre | Chicago White Sox | Toronto Blue Jays | Trade |
| Nov 6, 2000 | Signed as free agent | Mike Bell | — | Colorado Rockies | Free agent signing |
| Nov 6, 2000 | Signed as free agent | Mike Hubbard | — | Texas Rangers | Free agent signing |
| Nov 6, 2000 | Signed as free agent | Jason Maxwell | — | Minnesota Twins | Free agent signing |
| Nov 5, 2000 | Signed as free agent | Aaron Holbert | — | Toronto Blue Jays | Free agent signing |
| Nov 5, 2000 | Signed as free agent | Matt Miller | — | San Diego Padres | Free agent signing |
| Nov 3, 2000 | Signed as free agent | Miguel Batista | — | Arizona Diamondbacks | Free agent signing |
| Nov 3, 2000 | Signed as free agent | Ryan McGuire | — | Florida Marlins | Free agent signing |
| Nov 3, 2000 | Signed as free agent | Joe Strong | — | Florida Marlins | Free agent signing |
| Nov 2, 2000 | Signed as free agent | Ken Huckaby | — | Arizona Diamondbacks | Free agent signing |
| Nov 2, 2000 | Signed as free agent | Mike Mahoney | — | Chicago Cubs | Free agent signing |
| Nov 2, 2000 | Signed as free agent | Tony Mounce | — | Texas Rangers | Free agent signing |
| Nov 2, 2000 | Released | Hideo Nomo | Detroit Tigers | — | Release |
| Nov 2, 2000 | Signed | Brayan Peña | — | Atlanta Braves | Amateur free agent signing |
| Nov 2, 2000 | Signed as free agent | Bill Pulsipher | — | Tampa Bay Devil Rays | Free agent signing |
| Nov 2, 2000 | Signed as free agent | B. J. Waszgis | — | Florida Marlins | Free agent signing |
| Nov 1, 2000 | Released | Carlos Casimiro | Baltimore Orioles | — | Release |
| Nov 1, 2000 | Signed as free agent | Joey Dawley | — | Atlanta Braves | Free agent signing |
| Nov 1, 2000 | Signed as free agent | Adam Hyzdu | — | Pittsburgh Pirates | Free agent signing |
| Nov 1, 2000 | Signed as free agent | Travis Smith | — | Houston Astros | Free agent signing |
| Nov 1, 2000 | Signed as free agent | Alan Zinter | — | Houston Astros | Free agent signing |
| Oct 31, 2000 | Released | Bobby Bonilla | Atlanta Braves | — | Release |
| Oct 31, 2000 | Signed as free agent | Chris Oxspring | — | San Diego Padres | Free agent signing with first major-league team |
| Oct 30, 2000 | Signed as free agent | Rocky Coppinger | — | Milwaukee Brewers | Free agent signing |
| Oct 30, 2000 | Released | Ruben Sierra | Texas Rangers | — | Release |
| Oct 29, 2000 | Signed | Travis Blackley | — | Seattle Mariners | Amateur free agent signing |
| Oct 29, 2000 | Signed as free agent | Nate Bland | — | San Diego Padres | Free agent signing |
| Oct 27, 2000 | Signed as free agent | Carlos Castillo | — | Boston Red Sox | Free agent signing |
| Oct 26, 2000 | Signed as free agent | Willie Morales | — | Baltimore Orioles | Free agent signing |
| Oct 25, 2000 | Signed as free agent | Julio Mosquera | — | New York Yankees | Free agent signing |
| Oct 24, 2000 | Signed as free agent | Sean Runyan | — | Detroit Tigers | Free agent signing |
| Oct 20, 2000 | Released | Jamie Brewington | Cleveland Indians | — | Release |
| Oct 20, 2000 | Signed as free agent | Jason Pearson | — | Cincinnati Reds | Free agent signing |
| Oct 20, 2000 | Released | Bill Selby | Cleveland Indians | — | Release |
| Oct 17, 2000 | Released | Karim Garcia | Baltimore Orioles | — | Release |
| Oct 16, 2000 | Signed as free agent | Brent Cookson | — | Los Angeles Dodgers | Free agent signing |
| Oct 12, 2000 | Released | Jim Crowell | St. Louis Cardinals | — | Release |
| Oct 12, 2000 | Released | Dave Eiland | Tampa Bay Devil Rays | — | Release |
| Oct 10, 2000 | Signed as free agent | Robert Ellis | — | Arizona Diamondbacks | Free agent signing |
| Oct 9, 2000 | Released | Brad Clontz | Pittsburgh Pirates | — | Release |
| Oct 6, 2000 | Released | Chris Haney | Cleveland Indians | — | Release |
| Oct 5, 2000 | Released | Trent Hubbard | Baltimore Orioles | — | Release |
| Oct 5, 2000 | Signed | Jose Valdez | — | New York Yankees | Amateur free agent signing |
| Oct 5, 2000 | Released | Turner Ward | Arizona Diamondbacks | — | Release |
| Sep 28, 2000 | Trade | Terrmel Sledge | Seattle Mariners | Montreal Expos | Trade |
| Sep 27, 2000 | Signed as free agent | Jason Simontacchi | — | Minnesota Twins | Free agent signing |
| Sep 26, 2000 | Signed | Marcos Carvajal | — | Los Angeles Dodgers | Amateur free agent signing |
| Sep 20, 2000 | Trade | Jesus Peña | Chicago White Sox | Boston Red Sox | Trade |
| Sep 16, 2000 | Signed | Luis Hernandez | — | Atlanta Braves | Amateur free agent signing |
| Sep 14, 2000 | Signed | Pedro Lopez | — | Chicago White Sox | Amateur free agent signing |
| Sep 12, 2000 | Released | Stan Belinda | Atlanta Braves | — | Release |
| Sep 12, 2000 | Signed | Andy Marte | — | Atlanta Braves | Amateur free agent signing |
| Sep 10, 2000 | Signed as free agent | Steve Ontiveros | — | Boston Red Sox | Free agent signing |
| Sep 9, 2000 | Signed | Francisco Liriano | — | San Francisco Giants | Amateur free agent signing |
| Sep 9, 2000 | Released | Steve Ontiveros | Colorado Rockies | — | Release |
| Sep 9, 2000 | Trade | Lew Ford | Boston Red Sox | Minnesota Twins | Trade |
| Sep 9, 2000 | Trade | Hector Carrasco | Minnesota Twins | Boston Red Sox | Trade |
| Sep 8, 2000 | Signed as free agent | Jerry Spradlin | — | Chicago Cubs | Free agent signing |
| Sep 6, 2000 | Released | Robin Jennings | Cincinnati Reds | — | Release |
| Sep 5, 2000 | Released | Matt Karchner | Chicago Cubs | — | Release |
| Sep 2, 2000 | Signed | Ervin Santana | — | Anaheim Angels | Amateur free agent signing |
| Aug 31, 2000 | Signed as free agent | Ed Sprague | — | San Diego Padres | Free agent signing |
| Aug 31, 2000 | Trade | Hector De Los Santos | Boston Red Sox | Minnesota Twins | Trade |
| Aug 31, 2000 | Trade | Midre Cummings | Minnesota Twins | Boston Red Sox | Trade |
| Aug 31, 2000 | Trade | Chris Reitsma | Boston Red Sox | Cincinnati Reds | Trade |
| Aug 31, 2000 | Trade | John Curtice | Boston Red Sox | Cincinnati Reds | Trade |
| Aug 31, 2000 | Trade | Dante Bichette | Cincinnati Reds | Boston Red Sox | Trade |
| Aug 30, 2000 | Released | Jerry Spradlin | Kansas City Royals | — | Release |
| Aug 30, 2000 | Trade | Marco Scutaro | Cleveland Indians | Milwaukee Brewers | Trade |
| Aug 30, 2000 | Trade | Nelson Cruz | New York Mets | Oakland Athletics | Trade |
| Aug 30, 2000 | Trade | Jorge Velandia | Oakland Athletics | New York Mets | Trade |
| Aug 29, 2000 | Signed | Luis Cruz | — | Boston Red Sox | Amateur free agent signing |
| Aug 29, 2000 | Released | Ken Hill | Chicago White Sox | — | Release |
| Aug 25, 2000 | Signed as free agent | Rich Amaral | — | Atlanta Braves | Free agent signing |
| Aug 25, 2000 | Signed as free agent | Hector Ramirez | — | Houston Astros | Free agent signing |
| Aug 24, 2000 | Signed as free agent | Sean Berry | — | Cleveland Indians | Free agent signing |
| Aug 24, 2000 | Signed as free agent | Matt Mieske | — | Arizona Diamondbacks | Free agent signing |
| Aug 24, 2000 | Released | Hector Ramirez | Baltimore Orioles | — | Release |
| Aug 23, 2000 | Released | Ed Sprague | Boston Red Sox | — | Release |
| Aug 21, 2000 | Signed | Dioner Navarro | — | New York Yankees | Amateur free agent signing |
| Aug 18, 2000 | Signed as free agent | Ken Hill | — | Chicago White Sox | Free agent signing |
| Aug 17, 2000 | Released | Matt Mieske | Houston Astros | — | Release |
| Aug 16, 2000 | Signed as free agent | Orlando Merced | — | Houston Astros | Free agent signing |
| Aug 16, 2000 | Signed as free agent | Bryan Ward | — | Anaheim Angels | Free agent signing |
| Aug 15, 2000 | Signed as free agent | Jim Bullinger | — | Pittsburgh Pirates | Free agent signing |
| Aug 14, 2000 | Signed | Shin-Soo Choo | — | Seattle Mariners | Amateur free agent signing |
| Aug 12, 2000 | Released | Bryan Ward | Philadelphia Phillies | — | Release |
| Aug 12, 2000 | Trade | Jarrod Patterson | Pittsburgh Pirates | Montreal Expos | Trade |
| Aug 12, 2000 | Trade | Matt Skrmetta | Montreal Expos | Pittsburgh Pirates | Trade |
| Aug 11, 2000 | Signed as free agent | Darren Holmes | — | Arizona Diamondbacks | Free agent signing |
| Aug 11, 2000 | Signed as free agent | Mike Saipe | — | Anaheim Angels | Free agent signing |
| Aug 11, 2000 | Trade | Wilson Delgado | New York Yankees | Kansas City Royals | Trade |
| Aug 11, 2000 | Trade | Nick Ortiz | Kansas City Royals | New York Yankees | Trade |
| Aug 10, 2000 | Released | Sean Berry | Boston Red Sox | — | Release |
| Aug 10, 2000 | Signed as free agent | Brendan Donnelly | — | Chicago Cubs | Free agent signing |
| Aug 10, 2000 | Trade | Sean Spencer | Seattle Mariners | Montreal Expos | Trade |
| Aug 9, 2000 | Released | Trent Durrington | Anaheim Angels | — | Release |
| Aug 8, 2000 | Signed as free agent | Mark Dalesandro | — | Chicago Cubs | Free agent signing |
| Aug 8, 2000 | Signed as free agent | Brian Johnson | — | New York Yankees | Free agent signing |
| Aug 8, 2000 | Signed | Carlos Martinez | — | Florida Marlins | Amateur free agent signing |
| Aug 8, 2000 | Trade | Andy Bausher | Pittsburgh Pirates | San Diego Padres | Trade |
| Aug 8, 2000 | Trade | Peter Munro | Toronto Blue Jays | Texas Rangers | Trade |
| Aug 8, 2000 | Trade | Chris Widger | Montreal Expos | Seattle Mariners | Trade |
| Aug 7, 2000 | Signed as free agent | Joe Depastino | — | Houston Astros | Free agent signing |
| Aug 7, 2000 | Released | Ken Hill | Anaheim Angels | — | Release |
| Aug 7, 2000 | Signed as free agent | Vicente Palacios | — | Chicago Cubs | Free agent signing |
| Aug 7, 2000 | Trade | David Newhan | San Diego Padres | Philadelphia Phillies | Trade |
| Aug 7, 2000 | Trade | Rob Ducey | Toronto Blue Jays | Philadelphia Phillies | Trade |
| Aug 7, 2000 | Trade | Chris Spurling | New York Yankees | Pittsburgh Pirates | Trade |
| Aug 7, 2000 | Trade | Luis Sojo | Pittsburgh Pirates | New York Yankees | Trade |
| Aug 6, 2000 | Trade | Brian Hunter | Colorado Rockies | Cincinnati Reds | Trade |
| Aug 6, 2000 | Trade | Robert Averette | Cincinnati Reds | Colorado Rockies | Trade |
| Aug 5, 2000 | Signed as free agent | Jed Hansen | — | Cincinnati Reds | Free agent signing |
| Aug 5, 2000 | Trade | Mickey Morandini | Philadelphia Phillies | Toronto Blue Jays | Trade |
| Aug 4, 2000 | Released | Brian Johnson | St. Louis Cardinals | — | Release |
| Aug 4, 2000 | Signed as free agent | Mike Stanley | — | Oakland Athletics | Free agent signing |
| Aug 4, 2000 | Trade | Dave Martinez | Texas Rangers | Toronto Blue Jays | Trade |
| Aug 4, 2000 | Trade | Desi Relaford | Philadelphia Phillies | San Diego Padres | Trade |
| Aug 3, 2000 | Released | Dave Hollins | Baltimore Orioles | — | Release |
| Aug 3, 2000 | Signed as free agent | Dave Hollins | — | Cleveland Indians | Free agent signing |
| Aug 3, 2000 | Released | Vicente Palacios | San Diego Padres | — | Release |
| Aug 3, 2000 | Signed as free agent | Luis Polonia | — | New York Yankees | Free agent signing |
| Aug 3, 2000 | Released | Carlos Reyes | San Diego Padres | — | Release |
| Aug 2, 2000 | Signed | Andres Blanco | — | Kansas City Royals | Amateur free agent signing |
| Aug 2, 2000 | Released | Jed Hansen | New York Mets | — | Release |
| Aug 2, 2000 | Trade | Aaron Holbert | Boston Red Sox | Florida Marlins | Trade |
| Jul 31, 2000 | Released | Joe Depastino | Baltimore Orioles | — | Release |
| Jul 31, 2000 | Released | Luis Polonia | Detroit Tigers | — | Release |
| Jul 31, 2000 | Released | Mike Stanley | Boston Red Sox | — | Release |
| Jul 31, 2000 | Trade | John Sneed | Toronto Blue Jays | Philadelphia Phillies | Trade |
| Jul 31, 2000 | Trade | Gabe Molina | Baltimore Orioles | Atlanta Braves | Trade |
| Jul 31, 2000 | Trade | B. J. Surhoff | Baltimore Orioles | Atlanta Braves | Trade |
| Jul 31, 2000 | Trade | Trent Hubbard | Atlanta Braves | Baltimore Orioles | Trade |
| Jul 31, 2000 | Trade | Fernando Lunar | Atlanta Braves | Baltimore Orioles | Trade |
| Jul 31, 2000 | Trade | Luis Rivera | Atlanta Braves | Baltimore Orioles | Trade |
| Jul 31, 2000 | Trade | Unnamed | Baltimore Orioles | St. Louis Cardinals | $ |
| Jul 31, 2000 | Trade | Will Clark | Baltimore Orioles | St. Louis Cardinals | Trade |
| Jul 31, 2000 | Trade | Jose Leon | St. Louis Cardinals | Baltimore Orioles | Trade |
| Jul 31, 2000 | Trade | Jay Witasick | Kansas City Royals | San Diego Padres | Trade |
| Jul 31, 2000 | Trade | Brian Meadows | San Diego Padres | Kansas City Royals | Trade |
| Jul 31, 2000 | Trade | Danny Ardoin | Oakland Athletics | Minnesota Twins | Trade |
| Jul 31, 2000 | Trade | Mario Valdez | Minnesota Twins | Oakland Athletics | Trade |
| Jul 31, 2000 | Trade | Tom Davey | Seattle Mariners | San Diego Padres | Trade |
| Jul 31, 2000 | Trade | John Mabry | Seattle Mariners | San Diego Padres | Trade |
| Jul 31, 2000 | Trade | Al Martin | San Diego Padres | Seattle Mariners | Trade |
| Jul 31, 2000 | Trade | Mark Guthrie | Tampa Bay Devil Rays | Toronto Blue Jays | Trade |
| Jul 31, 2000 | Trade | Steve Trachsel | Tampa Bay Devil Rays | Toronto Blue Jays | Trade |
| Jul 31, 2000 | Trade | Brent Abernathy | Toronto Blue Jays | Tampa Bay Devil Rays | Trade |
| Jul 31, 2000 | Trade | Ross Gload | Florida Marlins | Chicago Cubs | Trade |
| Jul 31, 2000 | Trade | Dave Noyce | Florida Marlins | Chicago Cubs | Trade |
| Jul 31, 2000 | Trade | Henry Rodriguez | Chicago Cubs | Florida Marlins | Trade |
| Jul 31, 2000 | Trade | Rondell White | Montreal Expos | Chicago Cubs | Trade |
| Jul 31, 2000 | Trade | Scott Downs | Chicago Cubs | Montreal Expos | Trade |
| Jul 31, 2000 | Trade | Unnamed | Colorado Rockies | Los Angeles Dodgers | $ |
| Jul 31, 2000 | Trade | Todd Hollandsworth | Los Angeles Dodgers | Colorado Rockies | Trade |
| Jul 31, 2000 | Trade | Kevin Gibbs | Los Angeles Dodgers | Colorado Rockies | Trade |
| Jul 31, 2000 | Trade | Randey Dorame | Los Angeles Dodgers | Colorado Rockies | Trade |
| Jul 31, 2000 | Trade | Tom Goodwin | Colorado Rockies | Los Angeles Dodgers | Trade |
| Jul 31, 2000 | Trade | Juan Aracena | Baltimore Orioles | New York Mets | Trade |
| Jul 31, 2000 | Trade | Anthony Shumaker | New York Mets | Baltimore Orioles | Trade |
| Jul 31, 2000 | Trade | Carlos Hernandez | San Diego Padres | St. Louis Cardinals | Trade |
| Jul 31, 2000 | Trade | Nate Tebbs | San Diego Padres | St. Louis Cardinals | Trade |
| Jul 31, 2000 | Trade | Heathcliff Slocumb | St. Louis Cardinals | San Diego Padres | Trade |
| Jul 31, 2000 | Trade | Ben Johnson | St. Louis Cardinals | San Diego Padres | Trade |
| Jul 30, 2000 | Trade | Scott Linebrink | San Francisco Giants | Houston Astros | Trade |
| Jul 30, 2000 | Trade | Doug Henry | Houston Astros | San Francisco Giants | Trade |
| Jul 29, 2000 | Signed as free agent | Stan Belinda | — | Atlanta Braves | Free agent signing |
| Jul 29, 2000 | Trade | Miguel Felix | Chicago White Sox | Baltimore Orioles | Trade |
| Jul 29, 2000 | Trade | Juan Figueroa | Chicago White Sox | Baltimore Orioles | Trade |
| Jul 29, 2000 | Trade | Brook Fordyce | Chicago White Sox | Baltimore Orioles | Trade |
| Jul 29, 2000 | Trade | Jason Lakman | Chicago White Sox | Baltimore Orioles | Trade |
| Jul 29, 2000 | Trade | Harold Baines | Baltimore Orioles | Chicago White Sox | Trade |
| Jul 29, 2000 | Trade | Charles Johnson | Baltimore Orioles | Chicago White Sox | Trade |
| Jul 29, 2000 | Trade | Unnamed | Baltimore Orioles | St. Louis Cardinals | $ |
| Jul 29, 2000 | Trade | Mike Timlin | Baltimore Orioles | St. Louis Cardinals | Trade |
| Jul 29, 2000 | Trade | Chris Richard | St. Louis Cardinals | Baltimore Orioles | Trade |
| Jul 29, 2000 | Trade | Mark Nussbeck | St. Louis Cardinals | Baltimore Orioles | Trade |
| Jul 29, 2000 | Trade | Kent Bottenfield | Anaheim Angels | Philadelphia Phillies | Trade |
| Jul 29, 2000 | Trade | Ron Gant | Philadelphia Phillies | Anaheim Angels | Trade |
| Jul 29, 2000 | Trade | Jason Christiansen | Pittsburgh Pirates | St. Louis Cardinals | Trade |
| Jul 29, 2000 | Trade | Jack Wilson | St. Louis Cardinals | Pittsburgh Pirates | Trade |
| Jul 28, 2000 | Released | Rich Amaral | Baltimore Orioles | — | Release |
| Jul 28, 2000 | Released | Bubba Carpenter | Colorado Rockies | — | Release |
| Jul 28, 2000 | Released | Brendan Donnelly | Toronto Blue Jays | — | Release |
| Jul 28, 2000 | Signed as free agent | Robin Jennings | — | Cincinnati Reds | Free agent signing |
| Jul 28, 2000 | Signed as free agent | Lou Merloni | — | Boston Red Sox | Free agent signing |
| Jul 28, 2000 | Trade | Brett Hinchliffe | Anaheim Angels | Chicago Cubs | Trade |
| Jul 28, 2000 | Trade | Keith Luuloa | Anaheim Angels | Chicago Cubs | Trade |
| Jul 28, 2000 | Trade | Chris Hatcher | Chicago Cubs | Anaheim Angels | Trade |
| Jul 28, 2000 | Trade | Mike Heathcott | Chicago Cubs | Anaheim Angels | Trade |
| Jul 28, 2000 | Trade | Brett King | Chicago Cubs | Anaheim Angels | Trade |
| Jul 28, 2000 | Trade | Paul Rigdon | Cleveland Indians | Milwaukee Brewers | Trade |
| Jul 28, 2000 | Trade | Richie Sexson | Cleveland Indians | Milwaukee Brewers | Trade |
| Jul 28, 2000 | Trade | Kane Davis | Cleveland Indians | Milwaukee Brewers | Trade |
| Jul 28, 2000 | Trade | Bob Wickman | Milwaukee Brewers | Cleveland Indians | Trade |
| Jul 28, 2000 | Trade | Steve Woodard | Milwaukee Brewers | Cleveland Indians | Trade |
| Jul 28, 2000 | Trade | Jason Bere | Milwaukee Brewers | Cleveland Indians | Trade |
| Jul 28, 2000 | Trade | Alex Ramirez | Cleveland Indians | Pittsburgh Pirates | Trade |
| Jul 28, 2000 | Trade | Enrique Wilson | Cleveland Indians | Pittsburgh Pirates | Trade |
| Jul 28, 2000 | Trade | Wil Cordero | Pittsburgh Pirates | Cleveland Indians | Trade |
| Jul 28, 2000 | Trade | Todd Belitz | Tampa Bay Devil Rays | Oakland Athletics | Trade |
| Jul 28, 2000 | Trade | Jim Mecir | Tampa Bay Devil Rays | Oakland Athletics | Trade |
| Jul 28, 2000 | Trade | Jesus Colome | Oakland Athletics | Tampa Bay Devil Rays | Trade |
| Jul 28, 2000 | Trade | Ricky Ledee | Cleveland Indians | Texas Rangers | Trade |
| Jul 28, 2000 | Trade | David Segui | Texas Rangers | Cleveland Indians | Trade |
| Jul 28, 2000 | Trade | Mike Bordick | Baltimore Orioles | New York Mets | Trade |
| Jul 28, 2000 | Trade | Leslie Brea | New York Mets | Baltimore Orioles | Trade |
| Jul 28, 2000 | Trade | Pat Gorman | New York Mets | Baltimore Orioles | Trade |
| Jul 28, 2000 | Trade | Mike Kinkade | New York Mets | Baltimore Orioles | Trade |
| Jul 28, 2000 | Trade | Melvin Mora | New York Mets | Baltimore Orioles | Trade |
| Jul 28, 2000 | Trade | Bubba Trammell | Tampa Bay Devil Rays | New York Mets | Trade |
| Jul 28, 2000 | Trade | Rick White | Tampa Bay Devil Rays | New York Mets | Trade |
| Jul 28, 2000 | Trade | Jason Tyner | New York Mets | Tampa Bay Devil Rays | Trade |
| Jul 28, 2000 | Trade | Paul Wilson | New York Mets | Tampa Bay Devil Rays | Trade |
| Jul 27, 2000 | Released | Mike Saipe | San Diego Padres | — | Release |
| Jul 27, 2000 | Released | Jamie Walker | Kansas City Royals | — | Release |
| Jul 27, 2000 | Trade | Unnamed | Colorado Rockies | Boston Red Sox | $ |
| Jul 27, 2000 | Trade | Jeff Frye | Boston Red Sox | Colorado Rockies | Trade |
| Jul 27, 2000 | Trade | Brian Rose | Boston Red Sox | Colorado Rockies | Trade |
| Jul 27, 2000 | Trade | John Wasdin | Boston Red Sox | Colorado Rockies | Trade |
| Jul 27, 2000 | Trade | Jeff Taglienti | Boston Red Sox | Colorado Rockies | Trade |
| Jul 27, 2000 | Trade | Rolando Arrojo | Colorado Rockies | Boston Red Sox | Trade |
| Jul 27, 2000 | Trade | Rich Croushore | Colorado Rockies | Boston Red Sox | Trade |
| Jul 27, 2000 | Trade | Mike Lansing | Colorado Rockies | Boston Red Sox | Trade |
| Jul 26, 2000 | Released | Mark Dalesandro | Milwaukee Brewers | — | Release |
| Jul 26, 2000 | Signed | Justin Huber | — | New York Mets | Amateur free agent signing |
| Jul 26, 2000 | Trade | Curt Schilling | Philadelphia Phillies | Arizona Diamondbacks | Trade |
| Jul 26, 2000 | Trade | Omar Daal | Arizona Diamondbacks | Philadelphia Phillies | Trade |
| Jul 26, 2000 | Trade | Nelson Figueroa | Arizona Diamondbacks | Philadelphia Phillies | Trade |
| Jul 26, 2000 | Trade | Travis Lee | Arizona Diamondbacks | Philadelphia Phillies | Trade |
| Jul 26, 2000 | Trade | Vicente Padilla | Arizona Diamondbacks | Philadelphia Phillies | Trade |
| Jul 26, 2000 | Trade | Jorge Cordova | Florida Marlins | Cincinnati Reds | Trade |
| Jul 26, 2000 | Trade | Manny Aybar | Cincinnati Reds | Florida Marlins | Trade |
| Jul 26, 2000 | Trade | Unnamed | Los Angeles Dodgers | Chicago Cubs | $ |
| Jul 26, 2000 | Trade | Jamie Arnold | Los Angeles Dodgers | Chicago Cubs | Trade |
| Jul 26, 2000 | Trade | Jorge Piedra | Los Angeles Dodgers | Chicago Cubs | Trade |
| Jul 26, 2000 | Trade | Ismael Valdez | Chicago Cubs | Los Angeles Dodgers | Trade |
| Jul 26, 2000 | Trade | Rob Ducey | Philadelphia Phillies | Toronto Blue Jays | Trade |
| Jul 25, 2000 | Released | Stan Belinda | Colorado Rockies | — | Release |
| Jul 25, 2000 | Released | Robin Jennings | Minnesota Twins | — | Release |
| Jul 25, 2000 | Released | Bobby Munoz | Cincinnati Reds | — | Release |
| Jul 25, 2000 | Trade | Kevin Brown | Toronto Blue Jays | Milwaukee Brewers | Trade |
| Jul 25, 2000 | Trade | Alvin Morrow | Milwaukee Brewers | Toronto Blue Jays | Trade |
| Jul 24, 2000 | Released | Yorkis Perez | Houston Astros | — | Release |
| Jul 23, 2000 | Signed as free agent | Sean Berry | — | Boston Red Sox | Free agent signing |
| Jul 22, 2000 | Signed as free agent | Jim Crowell | — | St. Louis Cardinals | Free agent signing |
| Jul 21, 2000 | Released | Hansel Izquierdo | Cleveland Indians | — | Release |
| Jul 21, 2000 | Signed as free agent | Scott Sanders | — | Oakland Athletics | Free agent signing |
| Jul 21, 2000 | Trade | Ben Ford | New York Yankees | Chicago Cubs | Trade |
| Jul 21, 2000 | Trade | Oswaldo Mairena | New York Yankees | Chicago Cubs | Trade |
| Jul 21, 2000 | Trade | Glenallen Hill | Chicago Cubs | New York Yankees | Trade |
| Jul 20, 2000 | Released | Mike Garcia | Pittsburgh Pirates | — | Release |
| Jul 20, 2000 | Released | Scott Sanders | Florida Marlins | — | Release |
| Jul 19, 2000 | Signed | Yorman Bazardo | — | Florida Marlins | Amateur free agent signing |
| Jul 19, 2000 | Released | Darren Holmes | Baltimore Orioles | — | Release |
| Jul 19, 2000 | Trade | Darwin Cubillan | Toronto Blue Jays | Texas Rangers | Trade |
| Jul 19, 2000 | Trade | Michael Young | Toronto Blue Jays | Texas Rangers | Trade |
| Jul 19, 2000 | Trade | Esteban Loaiza | Texas Rangers | Toronto Blue Jays | Trade |
| Jul 18, 2000 | Signed as free agent | Curtis Pride | — | Los Angeles Dodgers | Free agent signing |
| Jul 17, 2000 | Signed as free agent | Mike Saipe | — | San Diego Padres | Free agent signing |
| Jul 17, 2000 | Signed as free agent | Clint Sodowsky | — | Texas Rangers | Free agent signing |
| Jul 17, 2000 | Trade | Gabe Alvarez | Detroit Tigers | San Diego Padres | Trade |
| Jul 17, 2000 | Trade | Dusty Allen | San Diego Padres | Detroit Tigers | Trade |
| Jul 15, 2000 | Trade | Unnamed | Colorado Rockies | Minnesota Twins | $ |
| Jul 15, 2000 | Trade | Butch Huskey | Minnesota Twins | Colorado Rockies | Trade |
| Jul 15, 2000 | Trade | Todd Walker | Minnesota Twins | Colorado Rockies | Trade |
| Jul 15, 2000 | Trade | Todd Sears | Colorado Rockies | Minnesota Twins | Trade |
| Jul 13, 2000 | Signed as free agent | Dave Hollins | — | Baltimore Orioles | Free agent signing |
| Jul 12, 2000 | Signed as free agent | Willie Banks | — | New York Mets | Free agent signing |
| Jul 12, 2000 | Signed as free agent | Joey Eischen | — | Montreal Expos | Free agent signing |
| Jul 12, 2000 | Signed | Luis Mendoza | — | Boston Red Sox | Amateur free agent signing |
| Jul 12, 2000 | Trade | Ed Yarnall | New York Yankees | Cincinnati Reds | Trade |
| Jul 12, 2000 | Trade | Drew Henson | New York Yankees | Cincinnati Reds | Trade |
| Jul 12, 2000 | Trade | Jackson Melian | New York Yankees | Cincinnati Reds | Trade |
| Jul 12, 2000 | Trade | Brian Reith | New York Yankees | Cincinnati Reds | Trade |
| Jul 12, 2000 | Trade | Mike Frank | Cincinnati Reds | New York Yankees | Trade |
| Jul 12, 2000 | Trade | Denny Neagle | Cincinnati Reds | New York Yankees | Trade |
| Jul 12, 2000 | Trade | Bruce Chen | Atlanta Braves | Philadelphia Phillies | Trade |
| Jul 12, 2000 | Trade | Jimmy Osting | Atlanta Braves | Philadelphia Phillies | Trade |
| Jul 12, 2000 | Trade | Andy Ashby | Philadelphia Phillies | Atlanta Braves | Trade |
| Jul 11, 2000 | Released | Jim Crowell | Cincinnati Reds | — | Release |
| Jul 11, 2000 | Signed as free agent | Brian Johnson | — | St. Louis Cardinals | Free agent signing |
| Jul 11, 2000 | Released | Mike Saipe | Colorado Rockies | — | Release |
| Jul 9, 2000 | Signed | Wladimir Balentien | — | Seattle Mariners | Amateur free agent signing |
| Jul 8, 2000 | Released | Curtis Pride | Boston Red Sox | — | Release |
| Jul 7, 2000 | Signed as free agent | Steve Ontiveros | — | Colorado Rockies | Free agent signing |
| Jul 6, 2000 | Signed as free agent | Mike Mohler | — | Oakland Athletics | Free agent signing |
| Jul 5, 2000 | Signed as free agent | Scott Kamieniecki | — | Atlanta Braves | Free agent signing |
| Jul 5, 2000 | Released | Mike Maddux | Houston Astros | — | Release |
| Jul 4, 2000 | Signed | Gregor Blanco | — | Atlanta Braves | Amateur free agent signing |
| Jul 4, 2000 | Signed as free agent | Bernard Gilkey | — | Boston Red Sox | Free agent signing |
| Jul 4, 2000 | Released | Scott Kamieniecki | Cleveland Indians | — | Release |
| Jul 3, 2000 | Released | Mark Clark | Texas Rangers | — | Release |
| Jul 3, 2000 | Signed as free agent | Jalal Leach | — | San Francisco Giants | Free agent signing |
| Jul 2, 2000 | Signed | Robinson Chirinos | — | Chicago Cubs | Amateur free agent signing |
| Jul 2, 2000 | Signed | Emiliano Fruto | — | Seattle Mariners | Amateur free agent signing |
| Jul 2, 2000 | Signed | Harvey Garcia | — | Florida Marlins | Amateur free agent signing |
| Jul 2, 2000 | Signed | Jesus Guzman | — | Seattle Mariners | Amateur free agent signing |
| Jul 2, 2000 | Signed as free agent | Mark Johnson | — | Detroit Tigers | Free agent signing |
| Jul 2, 2000 | Signed | Jose Lopez | — | Seattle Mariners | Amateur free agent signing |
| Jul 2, 2000 | Signed | Hanley Ramirez | — | Boston Red Sox | Amateur free agent signing |
| Jul 2, 2000 | Signed | Alex Romero | — | Minnesota Twins | Amateur free agent signing |
| Jun 30, 2000 | Released | Brian Johnson | Kansas City Royals | — | Release |
| Jun 30, 2000 | Trade | Ed Sprague | San Diego Padres | Boston Red Sox | Trade |
| Jun 30, 2000 | Trade | Cesar Saba | Boston Red Sox | San Diego Padres | Trade |
| Jun 30, 2000 | Trade | Dennis Tankersley | Boston Red Sox | San Diego Padres | Trade |
| Jun 29, 2000 | Trade | Ricky Ledee | New York Yankees | Cleveland Indians | Trade |
| Jun 29, 2000 | Trade | Jake Westbrook | New York Yankees | Cleveland Indians | Trade |
| Jun 29, 2000 | Trade | Zach Day | New York Yankees | Cleveland Indians | Trade |
| Jun 29, 2000 | Trade | David Justice | Cleveland Indians | New York Yankees | Trade |
| Jun 28, 2000 | Released | Mark Johnson | Detroit Tigers | — | Release |
| Jun 28, 2000 | Released | Jalal Leach | Philadelphia Phillies | — | Release |
| Jun 28, 2000 | Trade | Dan Serafini | San Diego Padres | Pittsburgh Pirates | Trade |
| Jun 27, 2000 | Signed | Alberto Arias | — | Colorado Rockies | Amateur free agent signing |
| Jun 27, 2000 | Released | Bernard Gilkey | Arizona Diamondbacks | — | Release |
| Jun 27, 2000 | Released | Orel Hershiser | Los Angeles Dodgers | — | Release |
| Jun 27, 2000 | Signed as free agent | Allen McDill | — | St. Louis Cardinals | Free agent signing |
| Jun 26, 2000 | Signed as free agent | Sean Bergman | — | Florida Marlins | Free agent signing |
| Jun 26, 2000 | Signed as free agent | Carlos Castillo | — | Boston Red Sox | Free agent signing |
| Jun 24, 2000 | Released | Allen McDill | Detroit Tigers | — | Release |
| Jun 23, 2000 | Released | Chris Tremie | Florida Marlins | — | Release |
| Jun 22, 2000 | Released | Sean Bergman | Minnesota Twins | — | Release |
| Jun 22, 2000 | Released | Charlie O'Brien | Montreal Expos | — | Release |
| Jun 21, 2000 | Released | Sean Berry | Milwaukee Brewers | — | Release |
| Jun 21, 2000 | Released | Clint Sodowsky | Cleveland Indians | — | Release |
| Jun 20, 2000 | Signed as free agent | Julio Manon | — | Montreal Expos | Free agent signing |
| Jun 20, 2000 | Signed as free agent | Scott Sanders | — | Florida Marlins | Free agent signing |
| Jun 20, 2000 | Trade | Unnamed | Los Angeles Dodgers | New York Yankees | $ |
| Jun 20, 2000 | Trade | Jim Leyritz | New York Yankees | Los Angeles Dodgers | Trade |
| Jun 20, 2000 | Trade | Jose Vizcaino | Los Angeles Dodgers | New York Yankees | Trade |
| Jun 18, 2000 | Released | Carlos Castillo | Florida Marlins | — | Release |
| Jun 18, 2000 | Signed as free agent | Julio Santana | — | Montreal Expos | Free agent signing |
| Jun 17, 2000 | Signed as free agent | Bobby Chouinard | — | Colorado Rockies | Free agent signing |
| Jun 17, 2000 | Signed as free agent | Kevin Orie | — | New York Yankees | Free agent signing |
| Jun 16, 2000 | Signed as free agent | Mike Mohler | — | Cleveland Indians | Free agent signing |
| Jun 16, 2000 | Signed as free agent | Jaime Navarro | — | Cleveland Indians | Free agent signing |
| Jun 16, 2000 | Released | Scott Sanders | Anaheim Angels | — | Release |
| Jun 15, 2000 | Released | Jaime Navarro | Colorado Rockies | — | Release |
| Jun 15, 2000 | Released | Kevin Orie | Kansas City Royals | — | Release |
| Jun 15, 2000 | Released | Julio Santana | Boston Red Sox | — | Release |
| Jun 13, 2000 | Trade | Eliezer Alfonzo | St. Louis Cardinals | Milwaukee Brewers | Trade |
| Jun 13, 2000 | Trade | Matt Parker | St. Louis Cardinals | Milwaukee Brewers | Trade |
| Jun 13, 2000 | Trade | Unnamed | Los Angeles Dodgers | Baltimore Orioles | $ |
| Jun 13, 2000 | Trade | Alberto Reyes | Baltimore Orioles | Los Angeles Dodgers | Trade |
| Jun 13, 2000 | Trade | Alan Mills | Los Angeles Dodgers | Baltimore Orioles | Trade |
| Jun 12, 2000 | Signed as free agent | Mike Buddie | — | Milwaukee Brewers | Free agent signing |
| Jun 12, 2000 | Released | Eric Knott | Arizona Diamondbacks | — | Release |
| Jun 12, 2000 | Trade | Mike Romano | Toronto Blue Jays | Minnesota Twins | Trade |
| Jun 12, 2000 | Trade | Francisco Alvarez | Minnesota Twins | Toronto Blue Jays | Trade |
| Jun 11, 2000 | Signed as free agent | Dwight Gooden | — | New York Yankees | Free agent signing |
| Jun 9, 2000 | Released | Mike Buddie | New York Yankees | — | Release |
| Jun 9, 2000 | Signed as free agent | Jim Poole | — | Cleveland Indians | Free agent signing |
| Jun 9, 2000 | Trade | Brant Brown | Florida Marlins | Texas Rangers | Trade |
| Jun 9, 2000 | Trade | Chuck Smith | Texas Rangers | Florida Marlins | Trade |
| Jun 9, 2000 | Trade | Dave Martinez | Chicago Cubs | Texas Rangers | Trade |
| Jun 9, 2000 | Trade | Brant Brown | Texas Rangers | Chicago Cubs | Trade |
| Jun 9, 2000 | Trade | Danny Bautista | Florida Marlins | Arizona Diamondbacks | Trade |
| Jun 9, 2000 | Trade | Andy Fox | Arizona Diamondbacks | Florida Marlins | Trade |
| Jun 8, 2000 | Signed as free agent | Hector Ramirez | — | Baltimore Orioles | Free agent signing |
| Jun 7, 2000 | Released | Jim Poole | Montreal Expos | — | Release |
| Jun 6, 2000 | Released | Lance Johnson | New York Yankees | — | Release |
| Jun 6, 2000 | Released | Masao Kida | Detroit Tigers | — | Release |
| Jun 5, 2000 | Released | Mike Mohler | St. Louis Cardinals | — | Release |
| Jun 5, 2000 | Signed as free agent | Brian Williams | — | Cleveland Indians | Free agent signing |
| Jun 2, 2000 | Signed | Adrian Hernandez | — | New York Yankees | Amateur free agent signing |
| Jun 2, 2000 | Released | Hector Ramirez | Milwaukee Brewers | — | Release |
| Jun 2, 2000 | Signed as free agent | Dan Smith | — | Boston Red Sox | Free agent signing |
| Jun 2, 2000 | Trade | Bill Pulsipher | New York Mets | Arizona Diamondbacks | Trade |
| Jun 2, 2000 | Trade | Lenny Harris | Arizona Diamondbacks | New York Mets | Trade |
| May 31, 2000 | Signed | Colter Bean | — | New York Yankees | Amateur free agent signing |
| May 31, 2000 | Trade | Tony Graffanino | Tampa Bay Devil Rays | Chicago White Sox | Trade |
| May 31, 2000 | Trade | Tanyon Sturtze | Chicago White Sox | Tampa Bay Devil Rays | Trade |
| May 30, 2000 | Signed as free agent | Hansel Izquierdo | — | Cleveland Indians | Free agent signing |
| May 30, 2000 | Signed as free agent | Kevin Stocker | — | Anaheim Angels | Free agent signing |
| May 30, 2000 | Released | Brian Williams | Chicago Cubs | — | Release |
| May 27, 2000 | Trade | Marc Valdes | Tampa Bay Devil Rays | Houston Astros | Trade |
| May 27, 2000 | Trade | Russ Johnson | Houston Astros | Tampa Bay Devil Rays | Trade |
| May 25, 2000 | Released | Dwight Gooden | Tampa Bay Devil Rays | — | Release |
| May 25, 2000 | Signed as free agent | Carlos Reyes | — | San Diego Padres | Free agent signing |
| May 25, 2000 | Released | Kevin Stocker | Tampa Bay Devil Rays | — | Release |
| May 24, 2000 | Signed as free agent | Scott Sanders | — | Anaheim Angels | Free agent signing |
| May 23, 2000 | Released | Robert Ellis | Toronto Blue Jays | — | Release |
| May 23, 2000 | Signed as free agent | Jed Hansen | — | New York Mets | Free agent signing |
| May 23, 2000 | Signed as free agent | Chris Jones | — | Milwaukee Brewers | Free agent signing |
| May 23, 2000 | Signed as free agent | Bart Miadich | — | Anaheim Angels | Free agent signing |
| May 22, 2000 | Signed as free agent | Reggie Harris | — | Milwaukee Brewers | Free agent signing |
| May 22, 2000 | Signed as free agent | Andrew Lorraine | — | Cleveland Indians | Free agent signing |
| May 21, 2000 | Released | Dave Hollins | Tampa Bay Devil Rays | — | Release |
| May 21, 2000 | Released | Andrew Lorraine | Chicago Cubs | — | Release |
| May 19, 2000 | Signed as free agent | Rickey Henderson | — | Seattle Mariners | Free agent signing |
| May 19, 2000 | Signed as free agent | Jim Poole | — | Montreal Expos | Free agent signing |
| May 18, 2000 | Signed | Jailen Peguero | — | Houston Astros | Amateur free agent signing |
| May 18, 2000 | Released | Brandon Puffer | Colorado Rockies | — | Release |
| May 18, 2000 | Signed as free agent | Scott Sanders | — | Cleveland Indians | Free agent signing |
| May 17, 2000 | Released | Brent Cookson | Los Angeles Dodgers | — | Release |
| May 17, 2000 | Signed as free agent | Marc Kroon | — | Los Angeles Dodgers | Free agent signing |
| May 17, 2000 | Released | Jim Poole | Detroit Tigers | — | Release |
| May 15, 2000 | Released | Jed Hansen | San Diego Padres | — | Release |
| May 15, 2000 | Released | Reggie Harris | Atlanta Braves | — | Release |
| May 15, 2000 | Signed as free agent | Jaime Navarro | — | Colorado Rockies | Free agent signing |
| May 15, 2000 | Trade | Gene Altman | Cincinnati Reds | Milwaukee Brewers | Trade |
| May 14, 2000 | Released | Scott Sanders | Cleveland Indians | — | Release |
| May 14, 2000 | Signed as free agent | Randall Simon | — | New York Yankees | Free agent signing |
| May 13, 2000 | Released | Rickey Henderson | New York Mets | — | Release |
| May 13, 2000 | Signed as free agent | Brian Shouse | — | Baltimore Orioles | Free agent signing |
| May 12, 2000 | Trade | Unnamed | Chicago Cubs | Tampa Bay Devil Rays | $ |
| May 12, 2000 | Trade | Dave Martinez | Tampa Bay Devil Rays | Chicago Cubs | Trade |
| May 12, 2000 | Trade | Mark Guthrie | Chicago Cubs | Tampa Bay Devil Rays | Trade |
| May 11, 2000 | Signed as free agent | Randy Knorr | — | Texas Rangers | Free agent signing |
| May 11, 2000 | Released | Carlos Reyes | Philadelphia Phillies | — | Release |
| May 10, 2000 | Signed as free agent | Rich Becker | — | Detroit Tigers | Free agent signing |
| May 10, 2000 | Signed as free agent | Mike Hubbard | — | Atlanta Braves | Free agent signing |
| May 10, 2000 | Signed as free agent | Chris Petersen | — | Atlanta Braves | Free agent signing |
| May 9, 2000 | Signed as free agent | Luis Ortiz | — | Arizona Diamondbacks | Free agent signing |
| May 9, 2000 | Signed as free agent | Tim Worrell | — | Chicago Cubs | Free agent signing |
| May 8, 2000 | Released | Mike Hubbard | Cincinnati Reds | — | Release |
| May 8, 2000 | Released | Marc Kroon | Los Angeles Dodgers | — | Release |
| May 8, 2000 | Released | Randall Simon | Florida Marlins | — | Release |
| May 8, 2000 | Released | Bobby Witt | Cleveland Indians | — | Release |
| May 7, 2000 | Signed | Kelvin Jimenez | — | Texas Rangers | Amateur free agent signing |
| May 6, 2000 | Released | Randy Knorr | Pittsburgh Pirates | — | Release |
| May 6, 2000 | Signed as free agent | Chris Michalak | — | Los Angeles Dodgers | Free agent signing |
| May 5, 2000 | Signed as free agent | Andy Barkett | — | Atlanta Braves | Free agent signing |
| May 5, 2000 | Released | Rich Becker | Oakland Athletics | — | Release |
| May 5, 2000 | Signed | Chien-Ming Wang | — | New York Yankees | Amateur free agent signing |
| May 4, 2000 | Released | Andy Barkett | Texas Rangers | — | Release |
| May 4, 2000 | Signed as free agent | Darren Holmes | — | St. Louis Cardinals | Free agent signing |
| May 4, 2000 | Released | Hansel Izquierdo | Chicago White Sox | — | Release |
| May 3, 2000 | Signed | Ivan Ochoa | — | Cleveland Indians | Amateur free agent signing |
| May 3, 2000 | Signed | Eider Torres | — | Cleveland Indians | Amateur free agent signing |
| May 1, 2000 | Signed as free agent | Tony Mounce | — | Texas Rangers | Free agent signing |
| May 1, 2000 | Signed as free agent | Ryan Thompson | — | New York Yankees | Free agent signing |
| May 1, 2000 | Released | Tim Worrell | Baltimore Orioles | — | Release |
| Apr 30, 2000 | Signed as free agent | Jeff Manto | — | Cleveland Indians | Free agent signing |
| Apr 30, 2000 | Released | Jaime Navarro | Milwaukee Brewers | — | Release |
| Apr 29, 2000 | Released | Joey Eischen | Cleveland Indians | — | Release |
| Apr 29, 2000 | Signed as free agent | Reggie Harris | — | Atlanta Braves | Free agent signing |
| Apr 29, 2000 | Released | Chris Jones | San Diego Padres | — | Release |
| Apr 28, 2000 | Released | Norm Charlton | Cincinnati Reds | — | Release |
| Apr 28, 2000 | Released | Mark Dalesandro | Toronto Blue Jays | — | Release |
| Apr 28, 2000 | Signed as free agent | Mark Dalesandro | — | Milwaukee Brewers | Free agent signing |
| Apr 28, 2000 | Released | Darren Holmes | Arizona Diamondbacks | — | Release |
| Apr 28, 2000 | Released | Jeff Manto | Colorado Rockies | — | Release |
| Apr 25, 2000 | Released | Chris Michalak | Tampa Bay Devil Rays | — | Release |
| Apr 25, 2000 | Trade | Brad Rigby | Kansas City Royals | Montreal Expos | Trade |
| Apr 25, 2000 | Trade | Miguel Batista | Montreal Expos | Kansas City Royals | Trade |
| Apr 20, 2000 | Released | Reggie Harris | Tampa Bay Devil Rays | — | Release |
| Apr 20, 2000 | Trade | Brian Dallimore | Houston Astros | Arizona Diamondbacks | Trade |
| Apr 20, 2000 | Trade | Josh McAffee | Arizona Diamondbacks | Houston Astros | Trade |
| Apr 18, 2000 | Signed | Edgar Gonzalez | — | Arizona Diamondbacks | Amateur free agent signing |
| Apr 17, 2000 | Signed | Freddy Guzman | — | San Diego Padres | Amateur free agent signing |
| Apr 17, 2000 | Signed as free agent | Tim Harikkala | — | Milwaukee Brewers | Free agent signing |
| Apr 14, 2000 | Released | Brian Shouse | New York Mets | — | Release |
| Apr 14, 2000 | Trade | Doug Johns | Milwaukee Brewers | Chicago Cubs | Trade |
| Apr 14, 2000 | Trade | Ray King | Chicago Cubs | Milwaukee Brewers | Trade |
| Apr 12, 2000 | Signed as free agent | Scott Sanders | — | Cleveland Indians | Free agent signing |
| Apr 12, 2000 | Signed as free agent | Dave Stevens | — | Atlanta Braves | Free agent signing |
| Apr 11, 2000 | Signed | Denny Bautista | — | Florida Marlins | Amateur free agent signing |
| Apr 10, 2000 | Signed as free agent | Todd Greene | — | Toronto Blue Jays | Free agent signing |
| Apr 10, 2000 | Signed as free agent | Johnny Ruffin | — | Arizona Diamondbacks | Free agent signing |
| Apr 9, 2000 | Signed as free agent | Norm Charlton | — | Cincinnati Reds | Free agent signing |
| Apr 9, 2000 | Signed as free agent | Kerry Robinson | — | New York Yankees | Free agent signing |
| Apr 7, 2000 | Trade | Manny Aybar | Colorado Rockies | Cincinnati Reds | Trade |
| Apr 7, 2000 | Trade | Gabe White | Cincinnati Reds | Colorado Rockies | Trade |
| Apr 6, 2000 | Signed as free agent | Brad Clontz | — | Pittsburgh Pirates | Free agent signing |
| Apr 5, 2000 | Signed as free agent | Carlos Castillo | — | Florida Marlins | Free agent signing |
| Apr 5, 2000 | Signed as free agent | Kevin Foster | — | Boston Red Sox | Free agent signing |
| Apr 5, 2000 | Released | Ozzie Guillen | Atlanta Braves | — | Release |
| Apr 5, 2000 | Signed as free agent | Ozzie Guillen | — | Tampa Bay Devil Rays | Free agent signing |
| Apr 5, 2000 | Signed as free agent | Heath Murray | — | Los Angeles Dodgers | Free agent signing |
| Apr 5, 2000 | Signed as free agent | Kevin Orie | — | Kansas City Royals | Free agent signing |
| Apr 5, 2000 | Signed as free agent | Randall Simon | — | Florida Marlins | Free agent signing |
| Apr 4, 2000 | Signed as free agent | Jay Canizaro | — | Minnesota Twins | Free agent signing |
| Apr 4, 2000 | Released | Eddie Gaillard | Cincinnati Reds | — | Release |
| Apr 4, 2000 | Released | Luis Ortiz | Texas Rangers | — | Release |
| Apr 3, 2000 | Released | Jay Canizaro | San Francisco Giants | — | Release |
| Apr 3, 2000 | Signed as free agent | Paul Spoljaric | — | Kansas City Royals | Free agent signing |
| Apr 2, 2000 | Signed as free agent | John Burkett | — | Atlanta Braves | Free agent signing |
| Apr 2, 2000 | Signed as free agent | Gary Gaetti | — | Boston Red Sox | Free agent signing |
| Apr 2, 2000 | Signed as free agent | Lance Johnson | — | New York Yankees | Free agent signing |
| Apr 2, 2000 | Signed as free agent | Felix Jose | — | New York Yankees | Free agent signing |
| Apr 2, 2000 | Signed as free agent | Pete Schourek | — | Boston Red Sox | Free agent signing |
| Apr 2, 2000 | Released | Ryan Thompson | New York Yankees | — | Release |
| Apr 1, 2000 | Signed as free agent | Shane Bowers | — | Philadelphia Phillies | Free agent signing |
| Apr 1, 2000 | Signed as free agent | Dustan Mohr | — | Minnesota Twins | Free agent signing |
| Apr 1, 2000 | Released | Dave Stevens | Pittsburgh Pirates | — | Release |
| Apr 1, 2000 | Trade | Juan Castro | Los Angeles Dodgers | Cincinnati Reds | Trade |
| Apr 1, 2000 | Trade | Kenny Lutz | Cincinnati Reds | Los Angeles Dodgers | Trade |
| Mar 31, 2000 | Released | Nate Bland | Los Angeles Dodgers | — | Release |
| Mar 31, 2000 | Released | Alberto Castillo | San Diego Padres | — | Release |
| Mar 31, 2000 | Released | Norm Charlton | Tampa Bay Devil Rays | — | Release |
| Mar 31, 2000 | Signed as free agent | Brian Hunter | — | Colorado Rockies | Free agent signing |
| Mar 31, 2000 | Released | Dustan Mohr | Cleveland Indians | — | Release |
| Mar 31, 2000 | Released | Tony Mounce | Houston Astros | — | Release |
| Mar 31, 2000 | Released | Randall Simon | Atlanta Braves | — | Release |
| Mar 31, 2000 | Signed as free agent | Billy Taylor | — | Tampa Bay Devil Rays | Free agent signing |
| Mar 30, 2000 | Released | Aaron Guiel | Oakland Athletics | — | Release |
| Mar 30, 2000 | Released | Lance Johnson | Cleveland Indians | — | Release |
| Mar 30, 2000 | Released | Mike Kelly | New York Mets | — | Release |
| Mar 30, 2000 | Released | Bart Miadich | Arizona Diamondbacks | — | Release |
| Mar 30, 2000 | Released | Kerry Robinson | Cincinnati Reds | — | Release |
| Mar 30, 2000 | Signed as free agent | Everett Stull | — | Milwaukee Brewers | Free agent signing |
| Mar 30, 2000 | Signed as free agent | Don Wengert | — | Atlanta Braves | Free agent signing |
| Mar 29, 2000 | Released | John Burkett | Tampa Bay Devil Rays | — | Release |
| Mar 29, 2000 | Released | Carlos Castillo | Chicago White Sox | — | Release |
| Mar 29, 2000 | Released | Brad Clontz | Arizona Diamondbacks | — | Release |
| Mar 29, 2000 | Released | Nate Field | Montreal Expos | — | Release |
| Mar 29, 2000 | Released | Todd Greene | Anaheim Angels | — | Release |
| Mar 29, 2000 | Released | Oscar Henriquez | San Diego Padres | — | Release |
| Mar 29, 2000 | Released | David Lundquist | Kansas City Royals | — | Release |
| Mar 29, 2000 | Released | Manny Martinez | Montreal Expos | — | Release |
| Mar 29, 2000 | Released | Heath Murray | Cincinnati Reds | — | Release |
| Mar 29, 2000 | Released | Kevin Orie | Los Angeles Dodgers | — | Release |
| Mar 29, 2000 | Released | Scott Sanders | Cleveland Indians | — | Release |
| Mar 29, 2000 | Released | Pete Schourek | Pittsburgh Pirates | — | Release |
| Mar 29, 2000 | Released | Paul Spoljaric | St. Louis Cardinals | — | Release |
| Mar 29, 2000 | Trade | Jason Dewey | Anaheim Angels | Colorado Rockies | Trade |
| Mar 29, 2000 | Trade | Norm Hutchins | Anaheim Angels | Colorado Rockies | Trade |
| Mar 29, 2000 | Trade | Edgard Clemente | Colorado Rockies | Anaheim Angels | Trade |
| Mar 29, 2000 | Trade | Yorkis Perez | Philadelphia Phillies | Houston Astros | Trade |
| Mar 29, 2000 | Trade | Trever Miller | Houston Astros | Philadelphia Phillies | Trade |
| Mar 28, 2000 | Released | Julio Manon | Milwaukee Brewers | — | Release |
| Mar 28, 2000 | Signed as free agent | Mike Porzio | — | Colorado Rockies | Free agent signing |
| Mar 28, 2000 | Signed as free agent | Clint Sodowsky | — | Cleveland Indians | Free agent signing |
| Mar 27, 2000 | Signed as free agent | Marty Cordova | — | Toronto Blue Jays | Free agent signing |
| Mar 27, 2000 | Released | Brian Hunter | Seattle Mariners | — | Release |
| Mar 27, 2000 | Signed as free agent | Marc Kroon | — | Los Angeles Dodgers | Free agent signing |
| Mar 27, 2000 | Released | Mike Porzio | Colorado Rockies | — | Release |
| Mar 27, 2000 | Signed | Ramon Ramirez | — | San Diego Padres | Amateur free agent signing |
| Mar 27, 2000 | Trade | Steve Falteisek | Cleveland Indians | Florida Marlins | Trade |
| Mar 27, 2000 | Trade | Victor Rodriguez | Florida Marlins | Cleveland Indians | Trade |
| Mar 26, 2000 | Released | Marty Cordova | Boston Red Sox | — | Release |
| Mar 26, 2000 | Signed as free agent | Greg McMichael | — | Atlanta Braves | Free agent signing |
| Mar 26, 2000 | Signed as free agent | Mike Oquist | — | Detroit Tigers | Free agent signing |
| Mar 26, 2000 | Signed as free agent | Steve Sparks | — | Detroit Tigers | Free agent signing |
| Mar 26, 2000 | Signed as free agent | Glenn Williams | — | Toronto Blue Jays | Free agent signing |
| Mar 25, 2000 | Released | Jim Bullinger | Los Angeles Dodgers | — | Release |
| Mar 25, 2000 | Signed as free agent | Raul Casanova | — | Milwaukee Brewers | Free agent signing |
| Mar 24, 2000 | Released | Raul Casanova | Colorado Rockies | — | Release |
| Mar 24, 2000 | Released | Chris Petersen | Chicago Cubs | — | Release |
| Mar 23, 2000 | Released | Mark Leiter | Pittsburgh Pirates | — | Release |
| Mar 23, 2000 | Released | Greg McMichael | Chicago Cubs | — | Release |
| Mar 23, 2000 | Released | Tim Raines | New York Yankees | — | Release |
| Mar 23, 2000 | Released | Steve Sparks | Philadelphia Phillies | — | Release |
| Mar 23, 2000 | Released | Billy Taylor | Colorado Rockies | — | Release |
| Mar 23, 2000 | Released | Glenn Williams | Atlanta Braves | — | Release |
| Mar 23, 2000 | Trade | Kent Bottenfield | St. Louis Cardinals | Anaheim Angels | Trade |
| Mar 23, 2000 | Trade | Adam Kennedy | St. Louis Cardinals | Anaheim Angels | Trade |
| Mar 23, 2000 | Trade | Jim Edmonds | Anaheim Angels | St. Louis Cardinals | Trade |
| Mar 23, 2000 | Trade | Gary Matthews | San Diego Padres | Chicago Cubs | Trade |
| Mar 23, 2000 | Trade | Rodney Myers | Chicago Cubs | San Diego Padres | Trade |
| Mar 23, 2000 | Trade | Wilson Delgado | San Francisco Giants | New York Yankees | Trade |
| Mar 23, 2000 | Trade | Juan Melo | New York Yankees | San Francisco Giants | Trade |
| Mar 22, 2000 | Signed as free agent | Charlie Hayes | — | Milwaukee Brewers | Free agent signing |
| Mar 22, 2000 | Released | Marc Kroon | Seattle Mariners | — | Release |
| Mar 22, 2000 | Trade | Christian Parker | Montreal Expos | New York Yankees | Trade |
| Mar 22, 2000 | Trade | Jim Mann | Toronto Blue Jays | New York Mets | Trade |
| Mar 22, 2000 | Trade | Jerson Perez | New York Mets | Toronto Blue Jays | Trade |
| Mar 21, 2000 | Released | Joe Borowski | Cincinnati Reds | — | Release |
| Mar 21, 2000 | Released | Kevin Foster | Milwaukee Brewers | — | Release |
| Mar 21, 2000 | Signed as free agent | Mike Rose | — | Arizona Diamondbacks | Free agent signing |
| Mar 21, 2000 | Trade | Carlos Maldonado | Seattle Mariners | Houston Astros | Trade |
| Mar 21, 2000 | Trade | Carlos Hernandez | Houston Astros | Seattle Mariners | Trade |
| Mar 20, 2000 | Signed as free agent | Craig Counsell | — | Arizona Diamondbacks | Free agent signing |
| Mar 20, 2000 | Released | Charlie Hayes | New York Mets | — | Release |
| Mar 20, 2000 | Signed as free agent | Joe Roa | — | Cleveland Indians | Free agent signing |
| Mar 20, 2000 | Released | Ruben Sierra | Cleveland Indians | — | Release |
| Mar 18, 2000 | Signed as free agent | Aaron Guiel | — | Oakland Athletics | Free agent signing |
| Mar 18, 2000 | Trade | Joe McEwing | St. Louis Cardinals | New York Mets | Trade |
| Mar 18, 2000 | Trade | Jesse Orosco | New York Mets | St. Louis Cardinals | Trade |
| Mar 17, 2000 | Trade | Ted Lilly | Montreal Expos | New York Yankees | Trade |
| Mar 16, 2000 | Released | Mike Rose | Houston Astros | — | Release |
| Mar 16, 2000 | Trade | Unnamed | Toronto Blue Jays | Texas Rangers | $ |
| Mar 16, 2000 | Trade | Lee Stevens | Texas Rangers | Montreal Expos | Trade |
| Mar 16, 2000 | Trade | David Segui | Toronto Blue Jays | Texas Rangers | Trade |
| Mar 16, 2000 | Trade | Brad Fullmer | Montreal Expos | Toronto Blue Jays | Trade |
| Mar 15, 2000 | Released | Craig Counsell | Los Angeles Dodgers | — | Release |
| Mar 15, 2000 | Released | Clint Sodowsky | Kansas City Royals | — | Release |
| Mar 14, 2000 | Signed as free agent | Robert Perez | — | Toronto Blue Jays | Free agent signing |
| Mar 14, 2000 | Released | Don Wengert | Houston Astros | — | Release |
| Mar 13, 2000 | Released | Mike Oquist | Detroit Tigers | — | Release |
| Mar 13, 2000 | Trade | Freddy Garcia | Atlanta Braves | Cincinnati Reds | Trade |
| Mar 13, 2000 | Trade | Dennis Russo | Cincinnati Reds | Atlanta Braves | Trade |
| Mar 10, 2000 | Trade | Wendell Magee | Philadelphia Phillies | Detroit Tigers | Trade |
| Mar 10, 2000 | Trade | Bobby Sismondo | Detroit Tigers | Philadelphia Phillies | Trade |
| Mar 5, 2000 | Released | Johnny Ruffin | Cincinnati Reds | — | Release |
| Mar 4, 2000 | Signed as free agent | Juan Diaz | — | Boston Red Sox | Free agent signing |
| Mar 1, 2000 | Signed | Omar Beltre | — | Texas Rangers | Amateur free agent signing |
| Feb 29, 2000 | Signed as free agent | Alberto Castillo | — | San Diego Padres | Free agent signing |
| Feb 27, 2000 | Signed as free agent | Chris Jones | — | San Diego Padres | Free agent signing |
| Feb 24, 2000 | Signed as free agent | Carlos Baerga | — | Tampa Bay Devil Rays | Free agent signing |
| Feb 24, 2000 | Signed as free agent | Benito Santiago | — | Cincinnati Reds | Free agent signing |
| Feb 24, 2000 | Signed as free agent | Tim Worrell | — | Baltimore Orioles | Free agent signing |
| Feb 23, 2000 | Trade | Unnamed | Pittsburgh Pirates | San Diego Padres | $ |
| Feb 23, 2000 | Trade | John Vander Wal | San Diego Padres | Pittsburgh Pirates | Trade |
| Feb 23, 2000 | Trade | Geraldo Padua | San Diego Padres | Pittsburgh Pirates | Trade |
| Feb 23, 2000 | Trade | Jim Sak | San Diego Padres | Pittsburgh Pirates | Trade |
| Feb 23, 2000 | Trade | Al Martin | Pittsburgh Pirates | San Diego Padres | Trade |
| Feb 22, 2000 | Signed as free agent | Steve Avery | — | Atlanta Braves | Free agent signing |
| Feb 22, 2000 | Signed as free agent | Mark Johnson | — | New York Mets | Free agent signing |
| Feb 22, 2000 | Signed | Jean Machi | — | Philadelphia Phillies | Amateur free agent signing |
| Feb 21, 2000 | Signed as free agent | Doug Linton | — | Colorado Rockies | Free agent signing |
| Feb 19, 2000 | Signed as free agent | Jim Bruske | — | Milwaukee Brewers | Free agent signing |
| Feb 19, 2000 | Signed as free agent | Turner Ward | — | Arizona Diamondbacks | Free agent signing |
| Feb 18, 2000 | Signed as free agent | Mark Whiten | — | Cleveland Indians | Free agent signing |
| Feb 18, 2000 | Trade | Brett Laxton | Oakland Athletics | Kansas City Royals | Trade |
| Feb 18, 2000 | Trade | Jeremy Giambi | Kansas City Royals | Oakland Athletics | Trade |
| Feb 16, 2000 | Signed as free agent | Eric Gunderson | — | Toronto Blue Jays | Free agent signing |
| Feb 16, 2000 | Signed as free agent | Andy Larkin | — | Cincinnati Reds | Free agent signing |
| Feb 16, 2000 | Signed as free agent | Felipe Lira | — | Montreal Expos | Free agent signing |
| Feb 16, 2000 | Signed | Juan Carlos Oviedo | — | Pittsburgh Pirates | Amateur free agent signing |
| Feb 15, 2000 | Signed as free agent | Osvaldo Fernandez | — | Cincinnati Reds | Free agent signing |
| Feb 15, 2000 | Signed as free agent | Pat Lennon | — | Montreal Expos | Free agent signing |
| Feb 15, 2000 | Signed as free agent | Scott McClain | — | Colorado Rockies | Free agent signing |
| Feb 15, 2000 | Signed as free agent | Walt McKeel | — | Colorado Rockies | Free agent signing |
| Feb 14, 2000 | Released | Andy Larkin | Chicago Cubs | — | Release |
| Feb 14, 2000 | Signed as free agent | Jarrod Patterson | — | Pittsburgh Pirates | Free agent signing |
| Feb 13, 2000 | Released | Jarrod Patterson | Pittsburgh Pirates | — | Release |
| Feb 11, 2000 | Signed as free agent | Hipolito Pichardo | — | Boston Red Sox | Free agent signing |
| Feb 10, 2000 | Trade | Ken Griffey | Seattle Mariners | Cincinnati Reds | Trade |
| Feb 10, 2000 | Trade | Mike Cameron | Cincinnati Reds | Seattle Mariners | Trade |
| Feb 10, 2000 | Trade | Brett Tomko | Cincinnati Reds | Seattle Mariners | Trade |
| Feb 10, 2000 | Trade | Jake Meyer | Cincinnati Reds | Seattle Mariners | Trade |
| Feb 10, 2000 | Trade | Antonio Perez | Cincinnati Reds | Seattle Mariners | Trade |
| Feb 9, 2000 | Signed as free agent | Mark Leiter | — | Pittsburgh Pirates | Free agent signing |
| Feb 9, 2000 | Signed as free agent | Josias Manzanillo | — | Pittsburgh Pirates | Free agent signing |
| Feb 9, 2000 | Signed as free agent | Dave Stevens | — | Pittsburgh Pirates | Free agent signing |
| Feb 8, 2000 | Signed as free agent | Chris Donnels | — | Los Angeles Dodgers | Free agent signing |
| Feb 8, 2000 | Signed as free agent | Greg McMichael | — | Chicago Cubs | Free agent signing |
| Feb 8, 2000 | Signed as free agent | Chris Nichting | — | Cleveland Indians | Free agent signing |
| Feb 8, 2000 | Signed as free agent | Rich Rodriguez | — | New York Mets | Free agent signing |
| Feb 7, 2000 | Signed as free agent | Kevin Foster | — | Milwaukee Brewers | Free agent signing |
| Feb 4, 2000 | Signed as free agent | Charlie O'Brien | — | Montreal Expos | Free agent signing |
| Feb 4, 2000 | Signed as free agent | Dennis Springer | — | New York Mets | Free agent signing |
| Feb 4, 2000 | Signed as free agent | Billy Taylor | — | Colorado Rockies | Free agent signing |
| Feb 3, 2000 | Signed as free agent | Shawon Dunston | — | St. Louis Cardinals | Free agent signing |
| Feb 3, 2000 | Signed as free agent | Eduardo Perez | — | St. Louis Cardinals | Free agent signing |
| Feb 3, 2000 | Signed as free agent | J. R. Phillips | — | Chicago White Sox | Free agent signing |
| Feb 3, 2000 | Signed as free agent | Ed Sprague | — | San Diego Padres | Free agent signing |
| Feb 3, 2000 | Signed as free agent | Rick Wilkins | — | St. Louis Cardinals | Free agent signing |
| Feb 2, 2000 | Released | Bobby Chouinard | Arizona Diamondbacks | — | Release |
| Feb 2, 2000 | Signed as free agent | Julio Santana | — | Boston Red Sox | Free agent signing |
| Feb 1, 2000 | Signed as free agent | Geronimo Berroa | — | Los Angeles Dodgers | Free agent signing |
| Feb 1, 2000 | Signed as free agent | Darren Bragg | — | Colorado Rockies | Free agent signing |
| Feb 1, 2000 | Signed as free agent | Doug Creek | — | Tampa Bay Devil Rays | Free agent signing |
| Feb 1, 2000 | Signed as free agent | Benji Gil | — | Anaheim Angels | Free agent signing |
| Feb 1, 2000 | Signed as free agent | Kip Gross | — | Houston Astros | Free agent signing |
| Feb 1, 2000 | Signed as free agent | Mike Maddux | — | Houston Astros | Free agent signing |
| Feb 1, 2000 | Signed as free agent | Tim Raines | — | New York Yankees | Free agent signing |
| Feb 1, 2000 | Released | Willis Roberts | Detroit Tigers | — | Release |
| Feb 1, 2000 | Signed as free agent | Willis Roberts | — | Cincinnati Reds | Free agent signing |
| Feb 1, 2000 | Signed as free agent | Steve Sparks | — | Philadelphia Phillies | Free agent signing |
| Feb 1, 2000 | Signed as free agent | Joe Strong | — | Florida Marlins | Free agent signing |
| Jan 31, 2000 | Signed | Willy Aybar | — | Los Angeles Dodgers | Amateur free agent signing |
| Jan 31, 2000 | Signed | Santiago Casilla | — | Oakland Athletics | Amateur free agent signing |
| Jan 31, 2000 | Signed as free agent | Javier Martinez | — | Cincinnati Reds | Free agent signing |
| Jan 29, 2000 | Signed as free agent | Kirk Bullinger | — | Philadelphia Phillies | Free agent signing |
| Jan 29, 2000 | Signed as free agent | Jed Hansen | — | San Diego Padres | Free agent signing |
| Jan 29, 2000 | Signed as free agent | Shea Hillenbrand | — | Boston Red Sox | Free agent signing |
| Jan 28, 2000 | Signed as free agent | Bobby Bonilla | — | Atlanta Braves | Free agent signing |
| Jan 28, 2000 | Signed as free agent | Pat Rapp | — | Baltimore Orioles | Free agent signing |
| Jan 28, 2000 | Signed as free agent | Steve Trachsel | — | Tampa Bay Devil Rays | Free agent signing |
| Jan 28, 2000 | Signed as free agent | Mark Wohlers | — | Cincinnati Reds | Free agent signing |
| Jan 27, 2000 | Signed as free agent | Pat Borders | — | Tampa Bay Devil Rays | Free agent signing |
| Jan 27, 2000 | Signed as free agent | Ricky Bottalico | — | Kansas City Royals | Free agent signing |
| Jan 27, 2000 | Signed as free agent | Butch Huskey | — | Minnesota Twins | Free agent signing |
| Jan 27, 2000 | Signed as free agent | Mickey Morandini | — | Montreal Expos | Free agent signing |
| Jan 27, 2000 | Signed as free agent | Darren Oliver | — | Texas Rangers | Free agent signing |
| Jan 27, 2000 | Signed as free agent | Scott Sanders | — | Cleveland Indians | Free agent signing |
| Jan 26, 2000 | Signed as free agent | Kurt Abbott | — | New York Mets | Free agent signing |
| Jan 26, 2000 | Signed as free agent | Steve Falteisek | — | Cleveland Indians | Free agent signing |
| Jan 26, 2000 | Signed as free agent | Roberto Kelly | — | New York Yankees | Free agent signing |
| Jan 26, 2000 | Signed as free agent | Curtis King | — | Cleveland Indians | Free agent signing |
| Jan 26, 2000 | Signed as free agent | Kent Mercker | — | Anaheim Angels | Free agent signing |
| Jan 26, 2000 | Signed as free agent | Alan Newman | — | Cleveland Indians | Free agent signing |
| Jan 26, 2000 | Signed as free agent | Hector Ramirez | — | Milwaukee Brewers | Free agent signing |
| Jan 26, 2000 | Signed as free agent | Jeff Tabaka | — | Colorado Rockies | Free agent signing |
| Jan 26, 2000 | Signed as free agent | Eric Weaver | — | Anaheim Angels | Free agent signing |
| Jan 25, 2000 | Signed as free agent | Toby Borland | — | Anaheim Angels | Free agent signing |
| Jan 24, 2000 | Signed as free agent | Tom Candiotti | — | Anaheim Angels | Free agent signing |
| Jan 24, 2000 | Signed as free agent | Russ Davis | — | San Francisco Giants | Free agent signing |
| Jan 24, 2000 | Signed as free agent | Steve Mintz | — | Anaheim Angels | Free agent signing |
| Jan 24, 2000 | Signed as free agent | Roy Smith | — | Cleveland Indians | Free agent signing |
| Jan 23, 2000 | Signed as free agent | Andy Sheets | — | Boston Red Sox | Free agent signing |
| Jan 21, 2000 | Signed as free agent | Frank Charles | — | Houston Astros | Free agent signing |
| Jan 21, 2000 | Signed as free agent | Hideo Nomo | — | Detroit Tigers | Free agent signing |
| Jan 21, 2000 | Trade | Luis Lopez | New York Mets | Milwaukee Brewers | Trade |
| Jan 21, 2000 | Trade | Bill Pulsipher | Milwaukee Brewers | New York Mets | Trade |
| Jan 20, 2000 | Signed as free agent | Trent Hubbard | — | Atlanta Braves | Free agent signing |
| Jan 20, 2000 | Signed as free agent | Chad Kreuter | — | Los Angeles Dodgers | Free agent signing |
| Jan 20, 2000 | Signed as free agent | Terry Mathews | — | Tampa Bay Devil Rays | Free agent signing |
| Jan 20, 2000 | Signed as free agent | Juan Melo | — | New York Yankees | Free agent signing |
| Jan 20, 2000 | Signed as free agent | Mark Portugal | — | Cincinnati Reds | Free agent signing |
| Jan 20, 2000 | Signed as free agent | Curtis Pride | — | New York Mets | Free agent signing |
| Jan 20, 2000 | Signed as free agent | Chris Prieto | — | Los Angeles Dodgers | Free agent signing |
| Jan 20, 2000 | Signed as free agent | Johnny Ruffin | — | Cincinnati Reds | Free agent signing |
| Jan 20, 2000 | Signed as free agent | Deion Sanders | — | Cincinnati Reds | Free agent signing |
| Jan 19, 2000 | Signed as free agent | Marty Cordova | — | Boston Red Sox | Free agent signing |
| Jan 19, 2000 | Signed as free agent | Jim Dougherty | — | St. Louis Cardinals | Free agent signing |
| Jan 19, 2000 | Signed as free agent | Willie Greene | — | Chicago Cubs | Free agent signing |
| Jan 19, 2000 | Signed as free agent | Charlie Hayes | — | New York Mets | Free agent signing |
| Jan 19, 2000 | Signed as free agent | Brett Hinchliffe | — | Anaheim Angels | Free agent signing |
| Jan 19, 2000 | Signed as free agent | John Hudek | — | St. Louis Cardinals | Free agent signing |
| Jan 19, 2000 | Signed as free agent | Joe Oliver | — | Seattle Mariners | Free agent signing |
| Jan 19, 2000 | Signed as free agent | Luis Sojo | — | Pittsburgh Pirates | Free agent signing |
| Jan 19, 2000 | Signed as free agent | Dave Wainhouse | — | St. Louis Cardinals | Free agent signing |
| Jan 19, 2000 | Signed as free agent | Bobby Witt | — | Cleveland Indians | Free agent signing |
| Jan 18, 2000 | Signed as free agent | David Segui | — | Toronto Blue Jays | Free agent signing |
| Jan 18, 2000 | Signed as free agent | Pedro Valdes | — | Texas Rangers | Free agent signing |
| Jan 18, 2000 | Signed as free agent | John Wehner | — | Pittsburgh Pirates | Free agent signing |
| Jan 18, 2000 | Signed as free agent | Eddie Zosky | — | Pittsburgh Pirates | Free agent signing |
| Jan 17, 2000 | Signed as free agent | John Burkett | — | Tampa Bay Devil Rays | Free agent signing |
| Jan 17, 2000 | Signed as free agent | Tyler Houston | — | Milwaukee Brewers | Free agent signing |
| Jan 17, 2000 | Signed as free agent | Keith Johnson | — | Anaheim Angels | Free agent signing |
| Jan 17, 2000 | Signed as free agent | Paul Wagner | — | New York Mets | Free agent signing |
| Jan 14, 2000 | Signed as free agent | Bobby Ayala | — | Minnesota Twins | Free agent signing |
| Jan 14, 2000 | Signed as free agent | Kevin Elster | — | Los Angeles Dodgers | Free agent signing |
| Jan 14, 2000 | Signed as free agent | Tony Fiore | — | Tampa Bay Devil Rays | Free agent signing |
| Jan 14, 2000 | Signed as free agent | Dave Hollins | — | Tampa Bay Devil Rays | Free agent signing |
| Jan 14, 2000 | Signed as free agent | Jeff Huson | — | Chicago Cubs | Free agent signing |
| Jan 14, 2000 | Signed as free agent | Brian Lesher | — | Seattle Mariners | Free agent signing |
| Jan 14, 2000 | Signed as free agent | Mike Morgan | — | Arizona Diamondbacks | Free agent signing |
| Jan 14, 2000 | Signed as free agent | Jose Parra | — | Pittsburgh Pirates | Free agent signing |
| Jan 14, 2000 | Signed as free agent | Bob Scanlan | — | Milwaukee Brewers | Free agent signing |
| Jan 14, 2000 | Signed as free agent | Marc Valdes | — | Tampa Bay Devil Rays | Free agent signing |
| Jan 14, 2000 | Trade | Alex Ochoa | Milwaukee Brewers | Cincinnati Reds | Trade |
| Jan 14, 2000 | Trade | Mark Sweeney | Cincinnati Reds | Milwaukee Brewers | Trade |
| Jan 14, 2000 | Trade | Masato Yoshii | New York Mets | Colorado Rockies | Trade |
| Jan 14, 2000 | Trade | Lariel Gonzalez | Colorado Rockies | New York Mets | Trade |
| Jan 14, 2000 | Trade | Bobby Jones | Colorado Rockies | New York Mets | Trade |
| Jan 13, 2000 | Signed as free agent | Cory Bailey | — | Pittsburgh Pirates | Free agent signing |
| Jan 13, 2000 | Signed as free agent | Lance Johnson | — | Cleveland Indians | Free agent signing |
| Jan 13, 2000 | Signed as free agent | Jesse Levis | — | Cleveland Indians | Free agent signing |
| Jan 13, 2000 | Signed as free agent | Terrell Lowery | — | San Francisco Giants | Free agent signing |
| Jan 13, 2000 | Signed as free agent | Lenny Webster | — | Montreal Expos | Free agent signing |
| Jan 12, 2000 | Signed as free agent | Jorge Fabregas | — | Kansas City Royals | Free agent signing |
| Jan 12, 2000 | Signed as free agent | Mendy Lopez | — | Florida Marlins | Free agent signing |
| Jan 12, 2000 | Trade | Cal Eldred | Milwaukee Brewers | Chicago White Sox | Trade |
| Jan 12, 2000 | Trade | Jose Valentin | Milwaukee Brewers | Chicago White Sox | Trade |
| Jan 12, 2000 | Trade | Jaime Navarro | Chicago White Sox | Milwaukee Brewers | Trade |
| Jan 12, 2000 | Trade | John Snyder | Chicago White Sox | Milwaukee Brewers | Trade |
| Jan 11, 2000 | Signed as free agent | F. P. Santangelo | — | Los Angeles Dodgers | Free agent signing |
| Jan 11, 2000 | Signed as free agent | Scott Spiezio | — | Anaheim Angels | Free agent signing |
| Jan 10, 2000 | Signed as free agent | Jason McDonald | — | Texas Rangers | Free agent signing |
| Jan 10, 2000 | Signed as free agent | Billy McMillon | — | Detroit Tigers | Free agent signing |
| Jan 10, 2000 | Signed as free agent | Gregg Olson | — | Los Angeles Dodgers | Free agent signing |
| Jan 10, 2000 | Signed as free agent | Aaron Sele | — | Seattle Mariners | Free agent signing |
| Jan 10, 2000 | Signed as free agent | Tim Spehr | — | Boston Red Sox | Free agent signing |
| Jan 10, 2000 | Signed as free agent | Tim Unroe | — | Atlanta Braves | Free agent signing |
| Jan 9, 2000 | Signed as free agent | Chris Michalak | — | Tampa Bay Devil Rays | Free agent signing |
| Jan 8, 2000 | Signed as free agent | Juan Guzman | — | Tampa Bay Devil Rays | Free agent signing |
| Jan 8, 2000 | Signed as free agent | Chris Haney | — | Cleveland Indians | Free agent signing |
| Jan 8, 2000 | Signed as free agent | Omar Olivares | — | Oakland Athletics | Free agent signing |
| Jan 7, 2000 | Signed as free agent | Andy Benes | — | St. Louis Cardinals | Free agent signing |
| Jan 7, 2000 | Signed as free agent | Norm Charlton | — | Tampa Bay Devil Rays | Free agent signing |
| Jan 7, 2000 | Signed as free agent | Ryan Jackson | — | Tampa Bay Devil Rays | Free agent signing |
| Jan 7, 2000 | Signed as free agent | Pat Kelly | — | Anaheim Angels | Free agent signing |
| Jan 7, 2000 | Signed as free agent | Luis Ortiz | — | Texas Rangers | Free agent signing |
| Jan 7, 2000 | Signed as free agent | Brian Williams | — | Chicago Cubs | Free agent signing |
| Jan 7, 2000 | Trade | Ken Ray | Kansas City Royals | San Francisco Giants | Trade |
| Jan 6, 2000 | Signed as free agent | Robert Ellis | — | Toronto Blue Jays | Free agent signing |
| Jan 6, 2000 | Signed as free agent | Dwight Gooden | — | Houston Astros | Free agent signing |
| Jan 6, 2000 | Signed as free agent | Reggie Harris | — | Tampa Bay Devil Rays | Free agent signing |
| Jan 6, 2000 | Signed as free agent | Jason Phillips | — | Pittsburgh Pirates | Free agent signing |
| Jan 5, 2000 | Signed as free agent | Domingo Cedeno | — | New York Mets | Free agent signing |
| Jan 5, 2000 | Signed as free agent | Don Wengert | — | Houston Astros | Free agent signing |
| Jan 5, 2000 | Signed as free agent | Ernie Young | — | St. Louis Cardinals | Free agent signing |
| Jan 4, 2000 | Signed as free agent | Israel Alcantara | — | Boston Red Sox | Free agent signing |
| Jan 4, 2000 | Signed as free agent | Raul Chavez | — | Houston Astros | Free agent signing |
| Jan 4, 2000 | Signed as free agent | Marcus Jensen | — | Minnesota Twins | Free agent signing |
| Jan 3, 2000 | Released | Bobby Bonilla | New York Mets | — | Release |
| Jan 3, 2000 | Signed as free agent | Jose Fernandez | — | Milwaukee Brewers | Free agent signing |
| Jan 3, 2000 | Released | Brett Hinchliffe | Seattle Mariners | — | Release |
| Jan 3, 2000 | Signed | Gustavo Molina | — | Chicago White Sox | Amateur free agent signing |
| Jan 3, 2000 | Signed as free agent | Joe Slusarski | — | Houston Astros | Free agent signing |
| Jan 1, 2000 | Signed as free agent | Terry Shumpert | — | Colorado Rockies | Free agent signing |
Every row is mapped onto the same trade / signing / release vocabulary the modern feed uses, with the era’s own type description kept on each row. Club names are the names of the day (the Boston Braves years, the Brooklyn Dodgers years), and each links to the franchise it is today. Some dates are only partially known or flagged approximate by the source; they are shown exactly as published, never completed to a fake precise day.