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The 2001 season’s official transaction log: 1,029 trades, signings and releases involving major-league clubs, listed newest first.
| Date | Type | Player | From | To | Details |
|---|---|---|---|---|---|
| Dec 31, 2001 | Signed as free agent | Mike Johnson | — | Los Angeles Dodgers | Free agent signing |
| Dec 31, 2001 | Signed as free agent | Jalal Leach | — | New York Yankees | Free agent signing |
| Dec 30, 2001 | Signed as free agent | Wilson Delgado | — | St. Louis Cardinals | Free agent signing |
| Dec 30, 2001 | Signed as free agent | Salomon Torres | — | Pittsburgh Pirates | Free agent signing |
| Dec 29, 2001 | Signed as free agent | Billy McMillon | — | Florida Marlins | Free agent signing |
| Dec 28, 2001 | Signed as free agent | Angel Echevarria | — | Chicago Cubs | Free agent signing |
| Dec 28, 2001 | Signed as free agent | John Frascatore | — | New York Mets | Free agent signing |
| Dec 28, 2001 | Signed as free agent | Rontrez Johnson | — | Kansas City Royals | Free agent signing |
| Dec 27, 2001 | Signed | Emilio Bonifacio | — | Arizona Diamondbacks | Amateur free agent signing |
| Dec 27, 2001 | Signed as free agent | Bryan Corey | — | Los Angeles Dodgers | Free agent signing |
| Dec 27, 2001 | Signed as free agent | Alan Embree | — | San Diego Padres | Free agent signing |
| Dec 27, 2001 | Signed as free agent | Hideki Irabu | — | Texas Rangers | Free agent signing |
| Dec 27, 2001 | Signed as free agent | Bill Pulsipher | — | Texas Rangers | Free agent signing |
| Dec 27, 2001 | Signed as free agent | Todd Williams | — | Los Angeles Dodgers | Free agent signing |
| Dec 27, 2001 | Trade | Ender Chavez | Colorado Rockies | New York Mets | Trade |
| Dec 27, 2001 | Trade | Mo Vaughn | Anaheim Angels | New York Mets | Trade |
| Dec 27, 2001 | Trade | Kevin Appier | New York Mets | Anaheim Angels | Trade |
| Dec 26, 2001 | Signed | Fabio Castro | — | Chicago White Sox | Amateur free agent signing |
| Dec 26, 2001 | Signed as free agent | Jonathan Johnson | — | Arizona Diamondbacks | Free agent signing |
| Dec 22, 2001 | Signed as free agent | Danny Ardoin | — | Kansas City Royals | Free agent signing |
| Dec 22, 2001 | Trade | Dave Roberts | Cleveland Indians | Los Angeles Dodgers | Trade |
| Dec 22, 2001 | Trade | Christian Bridenbaugh | Los Angeles Dodgers | Cleveland Indians | Trade |
| Dec 22, 2001 | Trade | Nial Hughes | Los Angeles Dodgers | Cleveland Indians | Trade |
| Dec 21, 2001 | Signed as free agent | Kirk Bullinger | — | Houston Astros | Free agent signing |
| Dec 21, 2001 | Signed as free agent | Mike Caruso | — | Cincinnati Reds | Free agent signing |
| Dec 21, 2001 | Signed as free agent | Alberto Castillo | — | New York Yankees | Free agent signing |
| Dec 21, 2001 | Signed as free agent | Jacob Cruz | — | Detroit Tigers | Free agent signing |
| Dec 21, 2001 | Signed as free agent | Johnny Damon | — | Boston Red Sox | Free agent signing |
| Dec 21, 2001 | Signed as free agent | Craig Dingman | — | Cincinnati Reds | Free agent signing |
| Dec 21, 2001 | Signed as free agent | Alex Hernandez | — | Cincinnati Reds | Free agent signing |
| Dec 21, 2001 | Signed as free agent | Brandon Kolb | — | Cincinnati Reds | Free agent signing |
| Dec 21, 2001 | Signed as free agent | Steve Lomasney | — | Boston Red Sox | Free agent signing |
| Dec 21, 2001 | Signed as free agent | C. J. Nitkowski | — | Houston Astros | Free agent signing |
| Dec 21, 2001 | Signed as free agent | Hideo Nomo | — | Los Angeles Dodgers | Free agent signing |
| Dec 21, 2001 | Signed as free agent | Chris Piersoll | — | Cincinnati Reds | Free agent signing |
| Dec 21, 2001 | Signed as free agent | F. P. Santangelo | — | New York Yankees | Free agent signing |
| Dec 21, 2001 | Signed as free agent | Mark Smith | — | Montreal Expos | Free agent signing |
| Dec 20, 2001 | Signed as free agent | Juan Acevedo | — | Detroit Tigers | Free agent signing |
| Dec 20, 2001 | Signed as free agent | Albie Lopez | — | Atlanta Braves | Free agent signing |
| Dec 20, 2001 | Signed as free agent | Everett Stull | — | Milwaukee Brewers | Free agent signing |
| Dec 20, 2001 | Trade | Jose Silva | Pittsburgh Pirates | Cincinnati Reds | Trade |
| Dec 20, 2001 | Trade | Ben Shaffar | Cincinnati Reds | Pittsburgh Pirates | Trade |
| Dec 19, 2001 | Signed as free agent | Moises Alou | — | Chicago Cubs | Free agent signing |
| Dec 19, 2001 | Signed as free agent | David Bell | — | Seattle Mariners | Free agent signing |
| Dec 19, 2001 | Signed as free agent | Dave Burba | — | Texas Rangers | Free agent signing |
| Dec 19, 2001 | Signed as free agent | John Burkett | — | Boston Red Sox | Free agent signing |
| Dec 19, 2001 | Signed as free agent | Dennis Cook | — | Anaheim Angels | Free agent signing |
| Dec 19, 2001 | Signed as free agent | Mark Johnson | — | New York Mets | Free agent signing |
| Dec 19, 2001 | Signed as free agent | Mike Judd | — | Cincinnati Reds | Free agent signing |
| Dec 19, 2001 | Signed as free agent | Bry Nelson | — | Boston Red Sox | Free agent signing |
| Dec 19, 2001 | Signed as free agent | Adam Riggs | — | Detroit Tigers | Free agent signing |
| Dec 19, 2001 | Signed as free agent | Nerio Rodriguez | — | Cleveland Indians | Free agent signing |
| Dec 19, 2001 | Trade | Michael Tucker | Chicago Cubs | Kansas City Royals | Trade |
| Dec 19, 2001 | Trade | Scott Hatteberg | Boston Red Sox | Colorado Rockies | Trade |
| Dec 19, 2001 | Trade | Pokey Reese | Colorado Rockies | Boston Red Sox | Trade |
| Dec 18, 2001 | Signed as free agent | Carlos Baerga | — | Boston Red Sox | Free agent signing |
| Dec 18, 2001 | Signed as free agent | Danny Bautista | — | Arizona Diamondbacks | Free agent signing |
| Dec 18, 2001 | Signed as free agent | Matt DeWitt | — | San Diego Padres | Free agent signing |
| Dec 18, 2001 | Signed as free agent | Jason Giambi | — | New York Yankees | Free agent signing |
| Dec 18, 2001 | Signed as free agent | Geremi Gonzalez | — | Texas Rangers | Free agent signing |
| Dec 18, 2001 | Signed as free agent | Jose Guillen | — | Arizona Diamondbacks | Free agent signing |
| Dec 18, 2001 | Signed as free agent | Sterling Hitchcock | — | New York Yankees | Free agent signing |
| Dec 18, 2001 | Signed as free agent | Chuck Knoblauch | — | Kansas City Royals | Free agent signing |
| Dec 18, 2001 | Signed as free agent | Brian Lesher | — | Toronto Blue Jays | Free agent signing |
| Dec 18, 2001 | Signed as free agent | Tino Martinez | — | St. Louis Cardinals | Free agent signing |
| Dec 18, 2001 | Signed as free agent | Dave Maurer | — | Cleveland Indians | Free agent signing |
| Dec 18, 2001 | Signed as free agent | Chad Mottola | — | Toronto Blue Jays | Free agent signing |
| Dec 18, 2001 | Signed as free agent | Heath Murray | — | Cleveland Indians | Free agent signing |
| Dec 18, 2001 | Signed as free agent | Jesus Peña | — | Milwaukee Brewers | Free agent signing |
| Dec 18, 2001 | Signed as free agent | Chris Peters | — | Toronto Blue Jays | Free agent signing |
| Dec 18, 2001 | Signed as free agent | Jason Schmidt | — | San Francisco Giants | Free agent signing |
| Dec 18, 2001 | Trade | Bernie Castro | New York Yankees | San Diego Padres | Trade |
| Dec 18, 2001 | Trade | Kevin Reese | San Diego Padres | New York Yankees | Trade |
| Dec 18, 2001 | Trade | Dave Elder | Texas Rangers | Cleveland Indians | Trade |
| Dec 18, 2001 | Trade | John Rocker | Cleveland Indians | Texas Rangers | Trade |
| Dec 18, 2001 | Trade | Pokey Reese | Cincinnati Reds | Colorado Rockies | Trade |
| Dec 18, 2001 | Trade | Dennys Reyes | Cincinnati Reds | Colorado Rockies | Trade |
| Dec 18, 2001 | Trade | Gabe White | Colorado Rockies | Cincinnati Reds | Trade |
| Dec 18, 2001 | Trade | Luke Hudson | Colorado Rockies | Cincinnati Reds | Trade |
| Dec 17, 2001 | Signed as free agent | Jeff Barry | — | Florida Marlins | Free agent signing |
| Dec 17, 2001 | Signed as free agent | Roger Cedeno | — | New York Mets | Free agent signing |
| Dec 17, 2001 | Signed as free agent | Derrin Ebert | — | Milwaukee Brewers | Free agent signing |
| Dec 17, 2001 | Signed as free agent | Julio Franco | — | Atlanta Braves | Free agent signing |
| Dec 17, 2001 | Signed as free agent | Derrick Gibson | — | Milwaukee Brewers | Free agent signing |
| Dec 17, 2001 | Signed as free agent | Ricky Gutierrez | — | Cleveland Indians | Free agent signing |
| Dec 17, 2001 | Signed as free agent | Yamid Haad | — | Tampa Bay Devil Rays | Free agent signing |
| Dec 17, 2001 | Signed as free agent | Darrell May | — | Kansas City Royals | Free agent signing |
| Dec 17, 2001 | Signed as free agent | Eddie Perez | — | Atlanta Braves | Free agent signing |
| Dec 17, 2001 | Released | Chris Piersoll | Cincinnati Reds | — | Release |
| Dec 17, 2001 | Signed as free agent | Chris Prieto | — | Houston Astros | Free agent signing |
| Dec 17, 2001 | Signed as free agent | Rondell White | — | New York Yankees | Free agent signing |
| Dec 17, 2001 | Trade | Corey Lee | Texas Rangers | Chicago White Sox | Trade |
| Dec 17, 2001 | Trade | Mickey Callaway | Tampa Bay Devil Rays | Anaheim Angels | Trade |
| Dec 17, 2001 | Trade | Wilmy Caceres | Anaheim Angels | Tampa Bay Devil Rays | Trade |
| Dec 16, 2001 | Signed as free agent | Brian O'Connor | — | Pittsburgh Pirates | Free agent signing |
| Dec 16, 2001 | Trade | Jose Paniagua | Seattle Mariners | Colorado Rockies | Trade |
| Dec 16, 2001 | Trade | Denny Stark | Seattle Mariners | Colorado Rockies | Trade |
| Dec 16, 2001 | Trade | Brian Fuentes | Seattle Mariners | Colorado Rockies | Trade |
| Dec 16, 2001 | Trade | Jeff Cirillo | Colorado Rockies | Seattle Mariners | Trade |
| Dec 16, 2001 | Trade | Tsuyoshi Shinjo | New York Mets | San Francisco Giants | Trade |
| Dec 16, 2001 | Trade | Desi Relaford | New York Mets | San Francisco Giants | Trade |
| Dec 16, 2001 | Trade | Shawn Estes | San Francisco Giants | New York Mets | Trade |
| Dec 15, 2001 | Signed as free agent | David Doster | — | Philadelphia Phillies | Free agent signing |
| Dec 15, 2001 | Signed as free agent | Dave Hollins | — | Philadelphia Phillies | Free agent signing |
| Dec 15, 2001 | Signed as free agent | Todd Pratt | — | Philadelphia Phillies | Free agent signing |
| Dec 15, 2001 | Signed as free agent | Johnny Ruffin | — | Kansas City Royals | Free agent signing |
| Dec 15, 2001 | Signed as free agent | Amaury Telemaco | — | Philadelphia Phillies | Free agent signing |
| Dec 15, 2001 | Trade | Rick Asadoorian | Boston Red Sox | St. Louis Cardinals | Trade |
| Dec 15, 2001 | Trade | Luis Garcia | Boston Red Sox | St. Louis Cardinals | Trade |
| Dec 15, 2001 | Trade | Dustin Brisson | Boston Red Sox | St. Louis Cardinals | Trade |
| Dec 15, 2001 | Trade | Dustin Hermanson | St. Louis Cardinals | Boston Red Sox | Trade |
| Dec 14, 2001 | Signed as free agent | Will Cunnane | — | Chicago Cubs | Free agent signing |
| Dec 14, 2001 | Signed as free agent | Marty Malloy | — | Florida Marlins | Free agent signing |
| Dec 14, 2001 | Trade | Mark Guthrie | Oakland Athletics | New York Mets | Trade |
| Dec 14, 2001 | Trade | Tyler Yates | Oakland Athletics | New York Mets | Trade |
| Dec 14, 2001 | Trade | David Justice | New York Mets | Oakland Athletics | Trade |
| Dec 13, 2001 | Signed as free agent | Craig Paquette | — | Detroit Tigers | Free agent signing |
| Dec 13, 2001 | Signed as free agent | Jay Powell | — | Texas Rangers | Free agent signing |
| Dec 13, 2001 | Released | Bryan Rekar | Tampa Bay Devil Rays | — | Release |
| Dec 13, 2001 | Signed as free agent | David Weathers | — | New York Mets | Free agent signing |
| Dec 13, 2001 | Released | Dan Wheeler | Tampa Bay Devil Rays | — | Release |
| Dec 13, 2001 | Trade | Kyle Kessel | New York Mets | Detroit Tigers | Trade |
| Dec 13, 2001 | Trade | Jim Deschaine | Chicago Cubs | Toronto Blue Jays | Trade |
| Dec 13, 2001 | Trade | Earl Snyder | New York Mets | Cleveland Indians | Trade |
| Dec 13, 2001 | Trade | Billy Traber | New York Mets | Cleveland Indians | Trade |
| Dec 13, 2001 | Trade | Paul Quantrill | Toronto Blue Jays | Los Angeles Dodgers | Trade |
| Dec 13, 2001 | Trade | Cesar Izturis | Toronto Blue Jays | Los Angeles Dodgers | Trade |
| Dec 13, 2001 | Trade | Luke Prokopec | Los Angeles Dodgers | Toronto Blue Jays | Trade |
| Dec 13, 2001 | Trade | Chad Ricketts | Los Angeles Dodgers | Toronto Blue Jays | Trade |
| Dec 13, 2001 | Trade | John Wasdin | Baltimore Orioles | Philadelphia Phillies | Trade |
| Dec 13, 2001 | Trade | Chris Brock | Philadelphia Phillies | Baltimore Orioles | Trade |
| Dec 13, 2001 | Trade | Kip Wells | Chicago White Sox | Pittsburgh Pirates | Trade |
| Dec 13, 2001 | Trade | Sean Lowe | Chicago White Sox | Pittsburgh Pirates | Trade |
| Dec 13, 2001 | Trade | Josh Fogg | Chicago White Sox | Pittsburgh Pirates | Trade |
| Dec 13, 2001 | Trade | Todd Ritchie | Pittsburgh Pirates | Chicago White Sox | Trade |
| Dec 13, 2001 | Trade | Lee Evans | Pittsburgh Pirates | Chicago White Sox | Trade |
| Dec 13, 2001 | Trade | Jay Witasick | New York Yankees | San Francisco Giants | Trade |
| Dec 13, 2001 | Trade | John Vander Wal | San Francisco Giants | New York Yankees | Trade |
| Dec 12, 2001 | Released | Alberto Castillo | Toronto Blue Jays | — | Release |
| Dec 12, 2001 | Signed as free agent | Norm Charlton | — | Seattle Mariners | Free agent signing |
| Dec 12, 2001 | Released | Steve Woodard | Cleveland Indians | — | Release |
| Dec 12, 2001 | Trade | Darren Oliver | Texas Rangers | Boston Red Sox | Trade |
| Dec 12, 2001 | Trade | Carl Everett | Boston Red Sox | Texas Rangers | Trade |
| Dec 11, 2001 | Signed as free agent | Vinny Castilla | — | Atlanta Braves | Free agent signing |
| Dec 11, 2001 | Signed as free agent | Jason Isringhausen | — | St. Louis Cardinals | Free agent signing |
| Dec 11, 2001 | Signed as free agent | Barry Wesson | — | Houston Astros | Free agent signing |
| Dec 11, 2001 | Signed as free agent | Gregg Zaun | — | Houston Astros | Free agent signing |
| Dec 11, 2001 | Trade | Roberto Alomar | Cleveland Indians | New York Mets | Trade |
| Dec 11, 2001 | Trade | Mike Bacsik | Cleveland Indians | New York Mets | Trade |
| Dec 11, 2001 | Trade | Danny Peoples | Cleveland Indians | New York Mets | Trade |
| Dec 11, 2001 | Trade | Matt Lawton | New York Mets | Cleveland Indians | Trade |
| Dec 11, 2001 | Trade | Alex Escobar | New York Mets | Cleveland Indians | Trade |
| Dec 11, 2001 | Trade | Jerrod Riggan | New York Mets | Cleveland Indians | Trade |
| Dec 11, 2001 | Trade | Unnamed | Seattle Mariners | San Diego Padres | $ |
| Dec 11, 2001 | Trade | Brett Tomko | Seattle Mariners | San Diego Padres | Trade |
| Dec 11, 2001 | Trade | Tom Lampkin | Seattle Mariners | San Diego Padres | Trade |
| Dec 11, 2001 | Trade | Ramon Vazquez | Seattle Mariners | San Diego Padres | Trade |
| Dec 11, 2001 | Trade | Ben Davis | San Diego Padres | Seattle Mariners | Trade |
| Dec 11, 2001 | Trade | Alex Arias | San Diego Padres | Seattle Mariners | Trade |
| Dec 11, 2001 | Trade | Wascar Serrano | San Diego Padres | Seattle Mariners | Trade |
| Dec 11, 2001 | Trade | Jesus Sanchez | Florida Marlins | Chicago Cubs | Trade |
| Dec 11, 2001 | Trade | Nate Teut | Chicago Cubs | Florida Marlins | Trade |
| Dec 11, 2001 | Trade | Juan Encarnacion | Detroit Tigers | Cincinnati Reds | Trade |
| Dec 11, 2001 | Trade | Luis Pineda | Detroit Tigers | Cincinnati Reds | Trade |
| Dec 11, 2001 | Trade | Dmitri Young | Cincinnati Reds | Detroit Tigers | Trade |
| Dec 10, 2001 | Signed | Victor Garate | — | Houston Astros | Amateur free agent signing |
| Dec 10, 2001 | Signed as free agent | Charlie Greene | — | Florida Marlins | Free agent signing |
| Dec 10, 2001 | Signed as free agent | Steve Randolph | — | Arizona Diamondbacks | Free agent signing |
| Dec 10, 2001 | Signed as free agent | Anthony Sanders | — | Cincinnati Reds | Free agent signing |
| Dec 10, 2001 | Signed as free agent | Bill Selby | — | Cleveland Indians | Free agent signing |
| Dec 10, 2001 | Signed as free agent | Pete Walker | — | New York Mets | Free agent signing |
| Dec 10, 2001 | Trade | Alex Gonzalez | Toronto Blue Jays | Chicago Cubs | Trade |
| Dec 10, 2001 | Trade | Felix Heredia | Chicago Cubs | Toronto Blue Jays | Trade |
| Dec 8, 2001 | Signed as free agent | Brian Shouse | — | Kansas City Royals | Free agent signing |
| Dec 7, 2001 | Signed as free agent | Luis Alicea | — | Kansas City Royals | Free agent signing |
| Dec 7, 2001 | Signed as free agent | Bret Boone | — | Seattle Mariners | Free agent signing |
| Dec 7, 2001 | Signed as free agent | Chris Gomez | — | Tampa Bay Devil Rays | Free agent signing |
| Dec 7, 2001 | Signed as free agent | Steve Karsay | — | New York Yankees | Free agent signing |
| Dec 7, 2001 | Signed as free agent | Randy Knorr | — | Montreal Expos | Free agent signing |
| Dec 7, 2001 | Signed as free agent | Javy Lopez | — | Atlanta Braves | Free agent signing |
| Dec 7, 2001 | Signed as free agent | Mendy Lopez | — | Pittsburgh Pirates | Free agent signing |
| Dec 7, 2001 | Signed as free agent | Mark McLemore | — | Seattle Mariners | Free agent signing |
| Dec 7, 2001 | Signed as free agent | Orlando Merced | — | Houston Astros | Free agent signing |
| Dec 7, 2001 | Signed as free agent | Luis Ordaz | — | Chicago Cubs | Free agent signing |
| Dec 7, 2001 | Signed as free agent | Jesse Orosco | — | Los Angeles Dodgers | Free agent signing |
| Dec 7, 2001 | Signed as free agent | Benito Santiago | — | San Francisco Giants | Free agent signing |
| Dec 7, 2001 | Signed as free agent | Rick Short | — | Anaheim Angels | Free agent signing |
| Dec 7, 2001 | Trade | David Justice | New York Yankees | New York Mets | Trade |
| Dec 7, 2001 | Trade | Robin Ventura | New York Mets | New York Yankees | Trade |
| Dec 7, 2001 | Trade | Eric Hinske | Oakland Athletics | Toronto Blue Jays | Trade |
| Dec 7, 2001 | Trade | Justin Miller | Oakland Athletics | Toronto Blue Jays | Trade |
| Dec 7, 2001 | Trade | Billy Koch | Toronto Blue Jays | Oakland Athletics | Trade |
| Dec 6, 2001 | Signed as free agent | Brady Anderson | — | Cleveland Indians | Free agent signing |
| Dec 6, 2001 | Signed as free agent | Marty Cordova | — | Baltimore Orioles | Free agent signing |
| Dec 6, 2001 | Signed as free agent | Julius Matos | — | San Diego Padres | Free agent signing |
| Dec 6, 2001 | Signed as free agent | Ryan Thompson | — | Milwaukee Brewers | Free agent signing |
| Dec 5, 2001 | Signed as free agent | Jason Christiansen | — | San Francisco Giants | Free agent signing |
| Dec 4, 2001 | Signed as free agent | Delino DeShields | — | Chicago Cubs | Free agent signing |
| Dec 4, 2001 | Signed as free agent | John Smoltz | — | Atlanta Braves | Free agent signing |
| Dec 3, 2001 | Signed as free agent | Kevin Beirne | — | Los Angeles Dodgers | Free agent signing |
| Dec 3, 2001 | Signed as free agent | Damon Buford | — | Boston Red Sox | Free agent signing |
| Dec 3, 2001 | Signed as free agent | Brian Hunter | — | Houston Astros | Free agent signing |
| Dec 3, 2001 | Released | Jalal Leach | San Francisco Giants | — | Release |
| Dec 3, 2001 | Signed as free agent | Yorkis Perez | — | Arizona Diamondbacks | Free agent signing |
| Dec 3, 2001 | Signed as free agent | Mac Suzuki | — | Kansas City Royals | Free agent signing |
| Dec 3, 2001 | Signed as free agent | Jose Vizcaino | — | Houston Astros | Free agent signing |
| Dec 1, 2001 | Signed as free agent | Walt McKeel | — | Colorado Rockies | Free agent signing |
| Nov 30, 2001 | Signed as free agent | Juan Alvarez | — | Texas Rangers | Free agent signing |
| Nov 30, 2001 | Released | Jacob Cruz | Colorado Rockies | — | Release |
| Nov 30, 2001 | Signed as free agent | Brian Powell | — | Detroit Tigers | Free agent signing |
| Nov 29, 2001 | Signed | Carlos Rosa | — | Kansas City Royals | Amateur free agent signing |
| Nov 29, 2001 | Signed as free agent | Andy Sheets | — | Tampa Bay Devil Rays | Free agent signing |
| Nov 28, 2001 | Signed as free agent | Jason Boyd | — | San Diego Padres | Free agent signing |
| Nov 28, 2001 | Released | Wayne Gomes | San Francisco Giants | — | Release |
| Nov 28, 2001 | Signed as free agent | Gabe Molina | — | St. Louis Cardinals | Free agent signing |
| Nov 28, 2001 | Signed as free agent | Peter Munro | — | Houston Astros | Free agent signing |
| Nov 28, 2001 | Released | Dante Powell | San Francisco Giants | — | Release |
| Nov 27, 2001 | Released | Jose Guillen | Tampa Bay Devil Rays | — | Release |
| Nov 27, 2001 | Signed as free agent | Mickey Lopez | — | Chicago Cubs | Free agent signing |
| Nov 27, 2001 | Signed as free agent | Ron Wright | — | Seattle Mariners | Free agent signing |
| Nov 27, 2001 | Signed as free agent | Ernie Young | — | St. Louis Cardinals | Free agent signing |
| Nov 27, 2001 | Trade | Herbert Perry | Chicago White Sox | Texas Rangers | Trade |
| Nov 26, 2001 | Signed as free agent | Jeff D'Amico | — | Cleveland Indians | Free agent signing |
| Nov 26, 2001 | Signed as free agent | Donzell McDonald | — | Cleveland Indians | Free agent signing |
| Nov 26, 2001 | Signed as free agent | Todd Van Poppel | — | Texas Rangers | Free agent signing |
| Nov 25, 2001 | Signed as free agent | Andy Abad | — | Florida Marlins | Free agent signing |
| Nov 23, 2001 | Signed as free agent | Mark Budzinski | — | Chicago Cubs | Free agent signing |
| Nov 23, 2001 | Signed as free agent | Rodrigo Lopez | — | Baltimore Orioles | Free agent signing |
| Nov 21, 2001 | Signed as free agent | Michael Coleman | — | Boston Red Sox | Free agent signing |
| Nov 21, 2001 | Signed as free agent | Mike Coolbaugh | — | St. Louis Cardinals | Free agent signing |
| Nov 21, 2001 | Signed as free agent | Dennis Springer | — | Los Angeles Dodgers | Free agent signing |
| Nov 20, 2001 | Signed as free agent | Joe Borowski | — | Chicago Cubs | Free agent signing |
| Nov 20, 2001 | Signed as free agent | Mike Difelice | — | St. Louis Cardinals | Free agent signing |
| Nov 20, 2001 | Signed as free agent | Gus Gandarillas | — | Milwaukee Brewers | Free agent signing |
| Nov 20, 2001 | Released | Chris Holt | Detroit Tigers | — | Release |
| Nov 20, 2001 | Signed as free agent | Jason Kershner | — | San Diego Padres | Free agent signing |
| Nov 20, 2001 | Signed as free agent | Andrew Lorraine | — | Milwaukee Brewers | Free agent signing |
| Nov 20, 2001 | Signed as free agent | Izzy Molina | — | Baltimore Orioles | Free agent signing |
| Nov 20, 2001 | Released | Heath Murray | Detroit Tigers | — | Release |
| Nov 20, 2001 | Signed as free agent | Eddie Oropesa | — | Arizona Diamondbacks | Free agent signing |
| Nov 20, 2001 | Signed as free agent | Hector Ortiz | — | Kansas City Royals | Free agent signing |
| Nov 20, 2001 | Signed as free agent | Joe Roa | — | Florida Marlins | Free agent signing |
| Nov 20, 2001 | Signed as free agent | Anthony Telford | — | Texas Rangers | Free agent signing |
| Nov 19, 2001 | Signed as free agent | Jorge Fabregas | — | Anaheim Angels | Free agent signing |
| Nov 19, 2001 | Signed as free agent | Pedro Feliciano | — | Cincinnati Reds | Free agent signing |
| Nov 19, 2001 | Signed as free agent | Chris Hammond | — | Atlanta Braves | Free agent signing |
| Nov 19, 2001 | Signed as free agent | Oscar Henriquez | — | Detroit Tigers | Free agent signing |
| Nov 19, 2001 | Released | Mike Kinkade | Baltimore Orioles | — | Release |
| Nov 19, 2001 | Signed as free agent | Chad Meyers | — | Oakland Athletics | Free agent signing |
| Nov 19, 2001 | Signed as free agent | Matt Miller | — | Oakland Athletics | Free agent signing |
| Nov 19, 2001 | Signed as free agent | Kevin Orie | — | Chicago Cubs | Free agent signing |
| Nov 19, 2001 | Signed as free agent | Jimmy Osting | — | Milwaukee Brewers | Free agent signing |
| Nov 19, 2001 | Signed as free agent | Jose Parra | — | Arizona Diamondbacks | Free agent signing |
| Nov 19, 2001 | Signed as free agent | Chris Petersen | — | Atlanta Braves | Free agent signing |
| Nov 19, 2001 | Signed as free agent | Matt Skrmetta | — | Kansas City Royals | Free agent signing |
| Nov 18, 2001 | Signed as free agent | Kevin Tolar | — | Pittsburgh Pirates | Free agent signing |
| Nov 18, 2001 | Signed as free agent | Dusty Wathan | — | San Diego Padres | Free agent signing |
| Nov 16, 2001 | Released | Brady Anderson | Baltimore Orioles | — | Release |
| Nov 16, 2001 | Signed as free agent | Toby Borland | — | Florida Marlins | Free agent signing |
| Nov 16, 2001 | Signed as free agent | Jayson Durocher | — | Milwaukee Brewers | Free agent signing |
| Nov 16, 2001 | Released | Geraldo Guzman | Arizona Diamondbacks | — | Release |
| Nov 16, 2001 | Released | David Lee | San Diego Padres | — | Release |
| Nov 16, 2001 | Released | Scott MacRae | Cincinnati Reds | — | Release |
| Nov 16, 2001 | Signed as free agent | Ryan McGuire | — | Baltimore Orioles | Free agent signing |
| Nov 16, 2001 | Signed as free agent | Aaron Miles | — | Chicago White Sox | Free agent signing |
| Nov 16, 2001 | Signed as free agent | Willie Morales | — | Arizona Diamondbacks | Free agent signing |
| Nov 16, 2001 | Signed as free agent | Jake Robbins | — | Atlanta Braves | Free agent signing |
| Nov 16, 2001 | Signed as free agent | Julio Santana | — | Detroit Tigers | Free agent signing |
| Nov 16, 2001 | Released | Jeff Tabaka | St. Louis Cardinals | — | Release |
| Nov 16, 2001 | Signed as free agent | Tim Young | — | Boston Red Sox | Free agent signing |
| Nov 15, 2001 | Signed as free agent | Mike Colangelo | — | Oakland Athletics | Free agent signing |
| Nov 15, 2001 | Signed as free agent | Travis Driskill | — | Baltimore Orioles | Free agent signing |
| Nov 15, 2001 | Signed as free agent | Greg Myers | — | Oakland Athletics | Free agent signing |
| Nov 15, 2001 | Signed | Yusmeiro Petit | — | New York Mets | Amateur free agent signing |
| Nov 15, 2001 | Signed as free agent | Kevin Witt | — | Cincinnati Reds | Free agent signing |
| Nov 14, 2001 | Signed as free agent | Brian Banks | — | Florida Marlins | Free agent signing |
| Nov 14, 2001 | Signed as free agent | Jason Dickson | — | Tampa Bay Devil Rays | Free agent signing |
| Nov 14, 2001 | Signed as free agent | Mike Porzio | — | Chicago White Sox | Free agent signing |
| Nov 14, 2001 | Signed as free agent | Kevin Sefcik | — | Tampa Bay Devil Rays | Free agent signing |
| Nov 14, 2001 | Signed as free agent | Travis Smith | — | St. Louis Cardinals | Free agent signing |
| Nov 13, 2001 | Signed | Melky Cabrera | — | New York Yankees | Amateur free agent signing |
| Nov 13, 2001 | Signed as free agent | Matt Duff | — | Florida Marlins | Free agent signing |
| Nov 13, 2001 | Signed as free agent | Jason Maxwell | — | Texas Rangers | Free agent signing |
| Nov 13, 2001 | Signed as free agent | Brian McNichol | — | Anaheim Angels | Free agent signing |
| Nov 13, 2001 | Signed as free agent | Rob Stanifer | — | Boston Red Sox | Free agent signing |
| Nov 12, 2001 | Signed as free agent | Luis Garcia | — | Baltimore Orioles | Free agent signing |
| Nov 12, 2001 | Released | Billy McMillon | Oakland Athletics | — | Release |
| Nov 12, 2001 | Signed as free agent | Juan Sosa | — | Detroit Tigers | Free agent signing |
| Nov 11, 2001 | Signed as free agent | Santiago Perez | — | Texas Rangers | Free agent signing |
| Nov 9, 2001 | Trade | Jesus Cordero | Los Angeles Dodgers | Philadelphia Phillies | Trade |
| Nov 9, 2001 | Trade | Eric Junge | Los Angeles Dodgers | Philadelphia Phillies | Trade |
| Nov 9, 2001 | Trade | Omar Daal | Philadelphia Phillies | Los Angeles Dodgers | Trade |
| Nov 8, 2001 | Signed as free agent | Mike Edwards | — | Cincinnati Reds | Free agent signing |
| Nov 8, 2001 | Signed as free agent | Matt Franco | — | Atlanta Braves | Free agent signing |
| Nov 8, 2001 | Signed as free agent | Ryan Freel | — | Tampa Bay Devil Rays | Free agent signing |
| Nov 8, 2001 | Signed as free agent | Adam Melhuse | — | Chicago Cubs | Free agent signing |
| Nov 8, 2001 | Signed as free agent | Trever Miller | — | Cincinnati Reds | Free agent signing |
| Nov 7, 2001 | Signed as free agent | Jason Beverlin | — | Cleveland Indians | Free agent signing |
| Nov 7, 2001 | Signed as free agent | Dave Borkowski | — | Detroit Tigers | Free agent signing |
| Nov 7, 2001 | Signed as free agent | Rocky Coppinger | — | Oakland Athletics | Free agent signing |
| Nov 7, 2001 | Signed as free agent | Chris Coste | — | Cleveland Indians | Free agent signing |
| Nov 7, 2001 | Signed as free agent | Luis de los Santos | — | Tampa Bay Devil Rays | Free agent signing |
| Nov 7, 2001 | Signed as free agent | David Lamb | — | Minnesota Twins | Free agent signing |
| Nov 7, 2001 | Signed as free agent | Brandon Villafuerte | — | San Diego Padres | Free agent signing |
| Nov 7, 2001 | Signed as free agent | Craig Wilson | — | Detroit Tigers | Free agent signing |
| Nov 6, 2001 | Signed as free agent | Jesse Levis | — | Cincinnati Reds | Free agent signing |
| Nov 6, 2001 | Released | F. P. Santangelo | Oakland Athletics | — | Release |
| Nov 6, 2001 | Signed as free agent | Jamie Walker | — | Detroit Tigers | Free agent signing |
| Nov 5, 2001 | Released | Dave Borkowski | Detroit Tigers | — | Release |
| Nov 5, 2001 | Signed as free agent | Mike Moriarty | — | Baltimore Orioles | Free agent signing |
| Nov 5, 2001 | Signed as free agent | Rob Sasser | — | Milwaukee Brewers | Free agent signing |
| Nov 5, 2001 | Released | Ruben Sierra | Texas Rangers | — | Release |
| Nov 3, 2001 | Signed | Roger Bernadina | — | Montreal Expos | Amateur free agent signing |
| Nov 3, 2001 | Signed as free agent | Dan Serafini | — | Anaheim Angels | Free agent signing |
| Nov 2, 2001 | Signed as free agent | Todd Dunwoody | — | Cleveland Indians | Free agent signing |
| Nov 2, 2001 | Signed as free agent | Mike Hubbard | — | Baltimore Orioles | Free agent signing |
| Nov 2, 2001 | Signed as free agent | Juan Melo | — | San Francisco Giants | Free agent signing |
| Nov 2, 2001 | Trade | Mark Bellhorn | Oakland Athletics | Chicago Cubs | Trade |
| Nov 2, 2001 | Trade | Adam Morrissey | Chicago Cubs | Oakland Athletics | Trade |
| Nov 1, 2001 | Signed as free agent | P. J. Forbes | — | Philadelphia Phillies | Free agent signing |
| Oct 31, 2001 | Signed | Joakim Soria | — | Los Angeles Dodgers | Amateur free agent signing |
| Oct 30, 2001 | Signed as free agent | Javier Martinez | — | Cincinnati Reds | Free agent signing |
| Oct 30, 2001 | Released | Ariel Prieto | Tampa Bay Devil Rays | — | Release |
| Oct 29, 2001 | Signed as free agent | Ben Ford | — | Chicago Cubs | Free agent signing |
| Oct 29, 2001 | Released | Ken Huckaby | Arizona Diamondbacks | — | Release |
| Oct 29, 2001 | Signed as free agent | Ryan Jackson | — | Detroit Tigers | Free agent signing |
| Oct 29, 2001 | Signed as free agent | Luis Jimenez | — | Baltimore Orioles | Free agent signing |
| Oct 29, 2001 | Signed | Edinson Volquez | — | Texas Rangers | Amateur free agent signing |
| Oct 27, 2001 | Signed as free agent | James Lofton | — | Boston Red Sox | Free agent signing |
| Oct 26, 2001 | Signed as free agent | Ken Cloude | — | Seattle Mariners | Free agent signing |
| Oct 26, 2001 | Signed as free agent | Mark Dalesandro | — | Chicago White Sox | Free agent signing |
| Oct 26, 2001 | Released | Jose Fernandez | Chicago Cubs | — | Release |
| Oct 26, 2001 | Signed as free agent | Jose Flores | — | Oakland Athletics | Free agent signing |
| Oct 26, 2001 | Signed as free agent | Jason Phillips | — | Cleveland Indians | Free agent signing |
| Oct 26, 2001 | Signed as free agent | Aaron Small | — | Atlanta Braves | Free agent signing |
| Oct 25, 2001 | Signed as free agent | Damon Hollins | — | Atlanta Braves | Free agent signing |
| Oct 22, 2001 | Signed as free agent | Joey Eischen | — | Montreal Expos | Free agent signing |
| Oct 22, 2001 | Released | Mike Gulan | Florida Marlins | — | Release |
| Oct 22, 2001 | Signed as free agent | David Lundquist | — | San Diego Padres | Free agent signing |
| Oct 22, 2001 | Signed | Edward Mujica | — | Cleveland Indians | Amateur free agent signing |
| Oct 22, 2001 | Signed as free agent | Jorge Velandia | — | New York Mets | Free agent signing |
| Oct 19, 2001 | Released | Chris Nichting | Colorado Rockies | — | Release |
| Oct 15, 2001 | Signed as free agent | Chris Brock | — | Philadelphia Phillies | Free agent signing |
| Oct 15, 2001 | Released | Damon Buford | Cincinnati Reds | — | Release |
| Oct 12, 2001 | Released | Chad Meyers | Chicago Cubs | — | Release |
| Oct 12, 2001 | Released | Mac Suzuki | Milwaukee Brewers | — | Release |
| Oct 12, 2001 | Trade | Randy Flores | New York Yankees | Texas Rangers | Trade |
| Oct 11, 2001 | Released | Rick Wilkins | San Diego Padres | — | Release |
| Oct 11, 2001 | Trade | Rosman Garcia | New York Yankees | Texas Rangers | Trade |
| Oct 10, 2001 | Signed | Jose Ascanio | — | Atlanta Braves | Amateur free agent signing |
| Oct 9, 2001 | Signed as free agent | Jamie Brown | — | Cleveland Indians | Free agent signing |
| Oct 9, 2001 | Released | Morgan Burkhart | Boston Red Sox | — | Release |
| Oct 9, 2001 | Released | Craig Grebeck | Boston Red Sox | — | Release |
| Oct 8, 2001 | Signed as free agent | Howie Clark | — | Baltimore Orioles | Free agent signing |
| Oct 2, 2001 | Signed | Junior Guerra | — | Atlanta Braves | Amateur free agent signing |
| Sep 26, 2001 | Released | Carlos Castillo | Boston Red Sox | — | Release |
| Sep 26, 2001 | Released | Luis Jimenez | Oakland Athletics | — | Release |
| Sep 21, 2001 | Signed | Jon Knott | — | San Diego Padres | Amateur free agent signing |
| Sep 19, 2001 | Signed as free agent | Chris Nichting | — | Colorado Rockies | Free agent signing |
| Sep 10, 2001 | Released | Trent Hubbard | Chicago Cubs | — | Release |
| Sep 10, 2001 | Released | Craig Wilson | Kansas City Royals | — | Release |
| Sep 6, 2001 | Signed | Frankie De La Cruz | — | Detroit Tigers | Amateur free agent signing |
| Sep 6, 2001 | Released | Hideki Irabu | Montreal Expos | — | Release |
| Sep 6, 2001 | Trade | Winston Abreu | Atlanta Braves | San Diego Padres | Trade |
| Sep 4, 2001 | Released | Mike Difelice | Arizona Diamondbacks | — | Release |
| Sep 4, 2001 | Trade | Mike Wenner | Oakland Athletics | Chicago Cubs | Trade |
| Sep 4, 2001 | Trade | Mike Fyhrie | Chicago Cubs | Oakland Athletics | Trade |
| Sep 3, 2001 | Signed as free agent | Andrew Lorraine | — | Philadelphia Phillies | Free agent signing |
| Sep 2, 2001 | Released | Andrew Lorraine | Florida Marlins | — | Release |
| Sep 2, 2001 | Trade | Unnamed | Detroit Tigers | New York Mets | $ |
| Sep 2, 2001 | Trade | C. J. Nitkowski | Detroit Tigers | New York Mets | Trade |
| Sep 1, 2001 | Released | Jamie Brown | Cleveland Indians | — | Release |
| Aug 31, 2001 | Trade | Randy Velarde | Texas Rangers | New York Yankees | Trade |
| Aug 31, 2001 | Trade | Rudy Seanez | San Diego Padres | Atlanta Braves | Trade |
| Aug 27, 2001 | Released | Kevin Foster | Texas Rangers | — | Release |
| Aug 27, 2001 | Signed | Eugenio Velez | — | Toronto Blue Jays | Amateur free agent signing |
| Aug 25, 2001 | Signed as free agent | Felipe Lira | — | Philadelphia Phillies | Free agent signing |
| Aug 23, 2001 | Signed as free agent | Willie Banks | — | Boston Red Sox | Free agent signing |
| Aug 23, 2001 | Trade | Gary Bennett | New York Mets | Colorado Rockies | Trade |
| Aug 19, 2001 | Signed as free agent | Quilvio Veras | — | Boston Red Sox | Free agent signing |
| Aug 18, 2001 | Signed as free agent | Damon Buford | — | Cincinnati Reds | Free agent signing |
| Aug 17, 2001 | Signed as free agent | Joey Hamilton | — | Cincinnati Reds | Free agent signing |
| Aug 16, 2001 | Released | Felipe Lira | Montreal Expos | — | Release |
| Aug 16, 2001 | Released | Rob Sasser | Montreal Expos | — | Release |
| Aug 15, 2001 | Released | Willie Banks | Toronto Blue Jays | — | Release |
| Aug 13, 2001 | Released | Brian Hunter | Toronto Blue Jays | — | Release |
| Aug 13, 2001 | Signed as free agent | Johnny Ruffin | — | Cincinnati Reds | Free agent signing |
| Aug 12, 2001 | Signed | Oswaldo Navarro | — | Seattle Mariners | Amateur free agent signing |
| Aug 11, 2001 | Signed as free agent | Jesse Levis | — | Milwaukee Brewers | Free agent signing |
| Aug 9, 2001 | Released | Damon Buford | Baltimore Orioles | — | Release |
| Aug 8, 2001 | Released | David Lamb | Colorado Rockies | — | Release |
| Aug 8, 2001 | Signed as free agent | David Lamb | — | Florida Marlins | Free agent signing |
| Aug 7, 2001 | Signed as free agent | Dan Serafini | — | Milwaukee Brewers | Free agent signing |
| Aug 7, 2001 | Released | Quilvio Veras | Atlanta Braves | — | Release |
| Aug 6, 2001 | Signed as free agent | John Wehner | — | Pittsburgh Pirates | Free agent signing |
| Aug 6, 2001 | Trade | Jason Smith | Chicago Cubs | Tampa Bay Devil Rays | Trade |
| Aug 6, 2001 | Trade | Joe Espada | Florida Marlins | Colorado Rockies | Trade |
| Aug 6, 2001 | Trade | Juan Acevedo | Colorado Rockies | Florida Marlins | Trade |
| Aug 5, 2001 | Signed as free agent | Brad Clontz | — | Atlanta Braves | Free agent signing |
| Aug 5, 2001 | Released | Dan Serafini | New York Mets | — | Release |
| Aug 3, 2001 | Released | Joey Hamilton | Toronto Blue Jays | — | Release |
| Aug 3, 2001 | Released | Jesse Levis | Atlanta Braves | — | Release |
| Aug 3, 2001 | Signed as free agent | Willie Morales | — | Colorado Rockies | Free agent signing |
| Aug 3, 2001 | Released | Johnny Ruffin | Florida Marlins | — | Release |
| Aug 3, 2001 | Released | Pete Schourek | Boston Red Sox | — | Release |
| Aug 3, 2001 | Signed as free agent | Ryan Thompson | — | Montreal Expos | Free agent signing |
| Aug 2, 2001 | Signed as free agent | Bryce Florie | — | Detroit Tigers | Free agent signing |
| Aug 2, 2001 | Signed as free agent | Charlie Greene | — | Atlanta Braves | Free agent signing |
| Aug 2, 2001 | Signed as free agent | J. R. Phillips | — | Colorado Rockies | Free agent signing |
| Aug 2, 2001 | Trade | Bobby Sismondo | Philadelphia Phillies | Milwaukee Brewers | Trade |
| Aug 2, 2001 | Trade | Unnamed | St. Louis Cardinals | San Diego Padres | $ |
| Aug 2, 2001 | Trade | Woody Williams | San Diego Padres | St. Louis Cardinals | Trade |
| Aug 2, 2001 | Trade | Ray Lankford | St. Louis Cardinals | San Diego Padres | Trade |
| Aug 1, 2001 | Released | Willie Morales | Baltimore Orioles | — | Release |
| Aug 1, 2001 | Released | Ryan Thompson | Florida Marlins | — | Release |
| Jul 31, 2001 | Released | John Frascatore | Toronto Blue Jays | — | Release |
| Jul 31, 2001 | Released | Jose Parra | Pittsburgh Pirates | — | Release |
| Jul 31, 2001 | Trade | Mike Trombley | Baltimore Orioles | Los Angeles Dodgers | Trade |
| Jul 31, 2001 | Trade | Geronimo Gil | Los Angeles Dodgers | Baltimore Orioles | Trade |
| Jul 31, 2001 | Trade | Kris Foster | Los Angeles Dodgers | Baltimore Orioles | Trade |
| Jul 31, 2001 | Trade | Tomo Ohka | Boston Red Sox | Montreal Expos | Trade |
| Jul 31, 2001 | Trade | Rich Rundles | Boston Red Sox | Montreal Expos | Trade |
| Jul 31, 2001 | Trade | Ugueth Urbina | Montreal Expos | Boston Red Sox | Trade |
| Jul 31, 2001 | Trade | Rey Sanchez | Kansas City Royals | Atlanta Braves | Trade |
| Jul 31, 2001 | Trade | Brad Voyles | Atlanta Braves | Kansas City Royals | Trade |
| Jul 31, 2001 | Trade | Alejandro Machado | Atlanta Braves | Kansas City Royals | Trade |
| Jul 31, 2001 | Trade | Unnamed | Colorado Rockies | Houston Astros | $ |
| Jul 31, 2001 | Trade | Scott Elarton | Houston Astros | Colorado Rockies | Trade |
| Jul 31, 2001 | Trade | Pedro Astacio | Colorado Rockies | Houston Astros | Trade |
| Jul 31, 2001 | Trade | Terry Mulholland | Pittsburgh Pirates | Los Angeles Dodgers | Trade |
| Jul 31, 2001 | Trade | Mike Fetters | Los Angeles Dodgers | Pittsburgh Pirates | Trade |
| Jul 31, 2001 | Trade | Adrian Burnside | Los Angeles Dodgers | Pittsburgh Pirates | Trade |
| Jul 31, 2001 | Trade | Zach Day | Cleveland Indians | Montreal Expos | Trade |
| Jul 31, 2001 | Trade | Milton Bradley | Montreal Expos | Cleveland Indians | Trade |
| Jul 31, 2001 | Trade | Tony McKnight | Houston Astros | Pittsburgh Pirates | Trade |
| Jul 31, 2001 | Trade | Mike Williams | Pittsburgh Pirates | Houston Astros | Trade |
| Jul 31, 2001 | Trade | Unnamed | San Francisco Giants | St. Louis Cardinals | $ |
| Jul 31, 2001 | Trade | Kevin Joseph | San Francisco Giants | St. Louis Cardinals | Trade |
| Jul 31, 2001 | Trade | Jason Christiansen | St. Louis Cardinals | San Francisco Giants | Trade |
| Jul 30, 2001 | Released | Bryce Florie | Boston Red Sox | — | Release |
| Jul 30, 2001 | Trade | Ruben Quevedo | Chicago Cubs | Milwaukee Brewers | Trade |
| Jul 30, 2001 | Trade | Peter Zoccolillo | Chicago Cubs | Milwaukee Brewers | Trade |
| Jul 30, 2001 | Trade | David Weathers | Milwaukee Brewers | Chicago Cubs | Trade |
| Jul 30, 2001 | Trade | Roberto Miniel | Milwaukee Brewers | Chicago Cubs | Trade |
| Jul 30, 2001 | Trade | Matt Lawton | Minnesota Twins | New York Mets | Trade |
| Jul 30, 2001 | Trade | Rick Reed | New York Mets | Minnesota Twins | Trade |
| Jul 30, 2001 | Trade | Jason Schmidt | Pittsburgh Pirates | San Francisco Giants | Trade |
| Jul 30, 2001 | Trade | John Vander Wal | Pittsburgh Pirates | San Francisco Giants | Trade |
| Jul 30, 2001 | Trade | Armando Rios | San Francisco Giants | Pittsburgh Pirates | Trade |
| Jul 30, 2001 | Trade | Ryan Vogelsong | San Francisco Giants | Pittsburgh Pirates | Trade |
| Jul 30, 2001 | Trade | Brett Jodie | New York Yankees | San Diego Padres | Trade |
| Jul 30, 2001 | Trade | Darren Blakely | New York Yankees | San Diego Padres | Trade |
| Jul 30, 2001 | Trade | Sterling Hitchcock | San Diego Padres | New York Yankees | Trade |
| Jul 29, 2001 | Signed as free agent | Dave Maurer | — | Oakland Athletics | Free agent signing |
| Jul 28, 2001 | Released | John Wehner | Pittsburgh Pirates | — | Release |
| Jul 28, 2001 | Trade | Mark Redman | Minnesota Twins | Detroit Tigers | Trade |
| Jul 28, 2001 | Trade | Todd Jones | Detroit Tigers | Minnesota Twins | Trade |
| Jul 27, 2001 | Released | Deion Sanders | Toronto Blue Jays | — | Release |
| Jul 27, 2001 | Trade | Fred McGriff | Tampa Bay Devil Rays | Chicago Cubs | Trade |
| Jul 27, 2001 | Trade | Manny Aybar | Chicago Cubs | Tampa Bay Devil Rays | Trade |
| Jul 27, 2001 | Trade | Bruce Chen | Philadelphia Phillies | New York Mets | Trade |
| Jul 27, 2001 | Trade | Adam Walker | Philadelphia Phillies | New York Mets | Trade |
| Jul 27, 2001 | Trade | Dennis Cook | New York Mets | Philadelphia Phillies | Trade |
| Jul 27, 2001 | Trade | Turk Wendell | New York Mets | Philadelphia Phillies | Trade |
| Jul 27, 2001 | Trade | Wayne Gomes | Philadelphia Phillies | San Francisco Giants | Trade |
| Jul 27, 2001 | Trade | Felipe Crespo | San Francisco Giants | Philadelphia Phillies | Trade |
| Jul 26, 2001 | Released | Dave Maurer | Cincinnati Reds | — | Release |
| Jul 26, 2001 | Trade | Unnamed | Chicago White Sox | Los Angeles Dodgers | $ |
| Jul 26, 2001 | Trade | James Baldwin | Chicago White Sox | Los Angeles Dodgers | Trade |
| Jul 26, 2001 | Trade | Jeff Barry | Los Angeles Dodgers | Chicago White Sox | Trade |
| Jul 26, 2001 | Trade | Onan Masaoka | Los Angeles Dodgers | Chicago White Sox | Trade |
| Jul 26, 2001 | Trade | Gary Majewski | Los Angeles Dodgers | Chicago White Sox | Trade |
| Jul 25, 2001 | Released | Darryl Hamilton | Colorado Rockies | — | Release |
| Jul 25, 2001 | Trade | Jermaine Dye | Kansas City Royals | Colorado Rockies | Trade |
| Jul 25, 2001 | Trade | Neifi Perez | Colorado Rockies | Kansas City Royals | Trade |
| Jul 25, 2001 | Trade | Todd Belitz | Oakland Athletics | Colorado Rockies | Trade |
| Jul 25, 2001 | Trade | Mario Encarnacion | Oakland Athletics | Colorado Rockies | Trade |
| Jul 25, 2001 | Trade | Jose Ortiz | Oakland Athletics | Colorado Rockies | Trade |
| Jul 25, 2001 | Trade | Jermaine Dye | Colorado Rockies | Oakland Athletics | Trade |
| Jul 25, 2001 | Trade | Albie Lopez | Tampa Bay Devil Rays | Arizona Diamondbacks | Trade |
| Jul 25, 2001 | Trade | Mike Difelice | Tampa Bay Devil Rays | Arizona Diamondbacks | Trade |
| Jul 25, 2001 | Trade | Jason Conti | Arizona Diamondbacks | Tampa Bay Devil Rays | Trade |
| Jul 25, 2001 | Trade | Nick Bierbrodt | Arizona Diamondbacks | Tampa Bay Devil Rays | Trade |
| Jul 24, 2001 | Released | Charlie Greene | San Diego Padres | — | Release |
| Jul 24, 2001 | Released | Oscar Henriquez | New York Mets | — | Release |
| Jul 24, 2001 | Trade | Andres Galarraga | Texas Rangers | San Francisco Giants | Trade |
| Jul 24, 2001 | Trade | Chris Magruder | San Francisco Giants | Texas Rangers | Trade |
| Jul 24, 2001 | Trade | Erasmo Ramirez | San Francisco Giants | Texas Rangers | Trade |
| Jul 24, 2001 | Trade | Todd Ozias | San Francisco Giants | Texas Rangers | Trade |
| Jul 23, 2001 | Signed as free agent | Chuck McElroy | — | San Diego Padres | Free agent signing |
| Jul 23, 2001 | Signed | Ryan Speier | — | Colorado Rockies | Amateur free agent signing |
| Jul 23, 2001 | Trade | Todd Pratt | New York Mets | Philadelphia Phillies | Trade |
| Jul 23, 2001 | Trade | Gary Bennett | Philadelphia Phillies | New York Mets | Trade |
| Jul 21, 2001 | Signed | Warner Madrigal | — | Anaheim Angels | Amateur free agent signing |
| Jul 20, 2001 | Signed | Rafael Rodriguez | — | Anaheim Angels | Amateur free agent signing |
| Jul 20, 2001 | Trade | Michael Tucker | Cincinnati Reds | Chicago Cubs | Trade |
| Jul 20, 2001 | Trade | Chris Booker | Chicago Cubs | Cincinnati Reds | Trade |
| Jul 20, 2001 | Trade | Ben Shaffar | Chicago Cubs | Cincinnati Reds | Trade |
| Jul 19, 2001 | Released | Chuck McElroy | Baltimore Orioles | — | Release |
| Jul 19, 2001 | Trade | Robin Jennings | Colorado Rockies | Cincinnati Reds | Trade |
| Jul 19, 2001 | Trade | Todd Walker | Colorado Rockies | Cincinnati Reds | Trade |
| Jul 19, 2001 | Trade | Alex Ochoa | Cincinnati Reds | Colorado Rockies | Trade |
| Jul 18, 2001 | Signed as free agent | Darryl Hamilton | — | Colorado Rockies | Free agent signing |
| Jul 18, 2001 | Signed as free agent | Chris Peters | — | New York Yankees | Free agent signing |
| Jul 17, 2001 | Signed as free agent | Chris Hammond | — | Atlanta Braves | Free agent signing |
| Jul 17, 2001 | Released | Chris Peters | Cincinnati Reds | — | Release |
| Jul 17, 2001 | Signed | Gregorio Petit | — | Oakland Athletics | Amateur free agent signing |
| Jul 16, 2001 | Released | Jason Ryan | Los Angeles Dodgers | — | Release |
| Jul 13, 2001 | Trade | McKay Christensen | Chicago White Sox | Los Angeles Dodgers | Trade |
| Jul 13, 2001 | Trade | Wade Parrish | Los Angeles Dodgers | Chicago White Sox | Trade |
| Jul 13, 2001 | Trade | Kimera Bartee | Anaheim Angels | Colorado Rockies | Trade |
| Jul 13, 2001 | Trade | Chone Figgins | Colorado Rockies | Anaheim Angels | Trade |
| Jul 12, 2001 | Signed | Joaquin Arias | — | New York Yankees | Amateur free agent signing |
| Jul 11, 2001 | Released | Darryl Hamilton | New York Mets | — | Release |
| Jul 11, 2001 | Trade | Bry Nelson | Arizona Diamondbacks | Pittsburgh Pirates | Trade |
| Jul 11, 2001 | Trade | Chris Petersen | Pittsburgh Pirates | Arizona Diamondbacks | Trade |
| Jul 10, 2001 | Trade | Emil Brown | Pittsburgh Pirates | San Diego Padres | Trade |
| Jul 10, 2001 | Trade | Shawn Camp | San Diego Padres | Pittsburgh Pirates | Trade |
| Jul 10, 2001 | Trade | Shawn Garrett | San Diego Padres | Pittsburgh Pirates | Trade |
| Jul 9, 2001 | Released | Charlie Hayes | Houston Astros | — | Release |
| Jul 9, 2001 | Released | Carlos Reyes | Arizona Diamondbacks | — | Release |
| Jul 9, 2001 | Signed | Danny Richar | — | Arizona Diamondbacks | Amateur free agent signing |
| Jul 7, 2001 | Signed as free agent | Delino DeShields | — | Chicago Cubs | Free agent signing |
| Jul 7, 2001 | Signed as free agent | Derrick Gibson | — | Arizona Diamondbacks | Free agent signing |
| Jul 6, 2001 | Signed as free agent | T. J. Mathews | — | St. Louis Cardinals | Free agent signing |
| Jul 5, 2001 | Signed as free agent | Ken Caminiti | — | Atlanta Braves | Free agent signing |
| Jul 5, 2001 | Released | Matt Whiteside | Atlanta Braves | — | Release |
| Jul 4, 2001 | Signed as free agent | Trent Hubbard | — | Chicago Cubs | Free agent signing |
| Jul 4, 2001 | Trade | Brian Boehringer | New York Yankees | San Francisco Giants | Trade |
| Jul 4, 2001 | Trade | Bobby Estalella | San Francisco Giants | New York Yankees | Trade |
| Jul 4, 2001 | Trade | Joe Smith | San Francisco Giants | New York Yankees | Trade |
| Jul 3, 2001 | Signed | Jose Garcia | — | Florida Marlins | Amateur free agent signing |
| Jul 3, 2001 | Released | Chris Hammond | Cleveland Indians | — | Release |
| Jul 3, 2001 | Signed | Juan Mateo | — | Chicago Cubs | Amateur free agent signing |
| Jul 3, 2001 | Signed | Adalberto Mendez | — | Chicago Cubs | Amateur free agent signing |
| Jul 3, 2001 | Signed as free agent | Lance Painter | — | Milwaukee Brewers | Free agent signing |
| Jul 3, 2001 | Signed | Felix Pie | — | Chicago Cubs | Amateur free agent signing |
| Jul 3, 2001 | Trade | Robin Jennings | Oakland Athletics | Colorado Rockies | Trade |
| Jul 3, 2001 | Trade | Ron Gant | Colorado Rockies | Oakland Athletics | Trade |
| Jul 3, 2001 | Trade | Hanley Frias | Minnesota Twins | St. Louis Cardinals | Trade |
| Jul 3, 2001 | Trade | Larry Sutton | St. Louis Cardinals | Minnesota Twins | Trade |
| Jul 2, 2001 | Released | Ken Caminiti | Texas Rangers | — | Release |
| Jul 2, 2001 | Released | Jim Crowell | San Diego Padres | — | Release |
| Jul 2, 2001 | Released | Luis de los Santos | New York Yankees | — | Release |
| Jul 2, 2001 | Released | Delino DeShields | Baltimore Orioles | — | Release |
| Jul 2, 2001 | Signed | Joel Guzman | — | Los Angeles Dodgers | Amateur free agent signing |
| Jul 2, 2001 | Signed | Cesar Jimenez | — | Seattle Mariners | Amateur free agent signing |
| Jul 2, 2001 | Signed as free agent | Dan Miceli | — | Colorado Rockies | Free agent signing |
| Jul 2, 2001 | Signed as free agent | Joe Oliver | — | Boston Red Sox | Free agent signing |
| Jul 2, 2001 | Signed | Felipe Paulino | — | Houston Astros | Amateur free agent signing |
| Jul 1, 2001 | Released | Brad Clontz | Colorado Rockies | — | Release |
| Jul 1, 2001 | Signed as free agent | Jose Rijo | — | Cincinnati Reds | Free agent signing |
| Jul 1, 2001 | Trade | Ricardo Aramboles | New York Yankees | Cincinnati Reds | Trade |
| Jul 1, 2001 | Trade | Mark Wohlers | Cincinnati Reds | New York Yankees | Trade |
| Jun 30, 2001 | Released | Derrick Gibson | Tampa Bay Devil Rays | — | Release |
| Jun 30, 2001 | Released | Pat Lennon | New York Yankees | — | Release |
| Jun 29, 2001 | Released | Gregg Olson | Los Angeles Dodgers | — | Release |
| Jun 29, 2001 | Released | Lance Painter | Toronto Blue Jays | — | Release |
| Jun 29, 2001 | Signed as free agent | Gerald Williams | — | New York Yankees | Free agent signing |
| Jun 29, 2001 | Trade | Unnamed | San Francisco Giants | Chicago White Sox | $ |
| Jun 29, 2001 | Trade | Derek Hasselhoff | Chicago White Sox | San Francisco Giants | Trade |
| Jun 29, 2001 | Trade | Alan Embree | San Francisco Giants | Chicago White Sox | Trade |
| Jun 28, 2001 | Released | Shane Andrews | St. Louis Cardinals | — | Release |
| Jun 27, 2001 | Signed as free agent | Chris Gomez | — | Tampa Bay Devil Rays | Free agent signing |
| Jun 27, 2001 | Signed as free agent | Deion Sanders | — | Toronto Blue Jays | Free agent signing |
| Jun 27, 2001 | Trade | Ron Villone | Colorado Rockies | Houston Astros | Trade |
| Jun 27, 2001 | Trade | Jay Powell | Houston Astros | Colorado Rockies | Trade |
| Jun 25, 2001 | Released | Dan Miceli | Florida Marlins | — | Release |
| Jun 24, 2001 | Released | Gerald Williams | Tampa Bay Devil Rays | — | Release |
| Jun 24, 2001 | Trade | Sal Fasano | Kansas City Royals | Colorado Rockies | Trade |
| Jun 24, 2001 | Trade | Mac Suzuki | Kansas City Royals | Colorado Rockies | Trade |
| Jun 24, 2001 | Trade | Brent Mayne | Colorado Rockies | Kansas City Royals | Trade |
| Jun 23, 2001 | Signed as free agent | Greg Myers | — | Oakland Athletics | Free agent signing |
| Jun 23, 2001 | Signed as free agent | Scott Service | — | Cincinnati Reds | Free agent signing |
| Jun 23, 2001 | Trade | Dave Mlicki | Detroit Tigers | Houston Astros | Trade |
| Jun 23, 2001 | Trade | Jose Lima | Houston Astros | Detroit Tigers | Trade |
| Jun 23, 2001 | Trade | D'Angelo Jimenez | New York Yankees | San Diego Padres | Trade |
| Jun 23, 2001 | Trade | Jay Witasick | San Diego Padres | New York Yankees | Trade |
| Jun 22, 2001 | Signed as free agent | Rick DeHart | — | Kansas City Royals | Free agent signing |
| Jun 22, 2001 | Released | Chris Gomez | San Diego Padres | — | Release |
| Jun 22, 2001 | Released | T. J. Mathews | Oakland Athletics | — | Release |
| Jun 22, 2001 | Released | Deion Sanders | Cincinnati Reds | — | Release |
| Jun 22, 2001 | Trade | Steve Karsay | Cleveland Indians | Atlanta Braves | Trade |
| Jun 22, 2001 | Trade | Steve Reed | Cleveland Indians | Atlanta Braves | Trade |
| Jun 22, 2001 | Trade | John Rocker | Atlanta Braves | Cleveland Indians | Trade |
| Jun 22, 2001 | Trade | Troy Cameron | Atlanta Braves | Cleveland Indians | Trade |
| Jun 21, 2001 | Released | Russ Davis | San Francisco Giants | — | Release |
| Jun 20, 2001 | Released | Joe Oliver | New York Yankees | — | Release |
| Jun 20, 2001 | Trade | Cary Ammons | Kansas City Royals | Cincinnati Reds | Trade |
| Jun 20, 2001 | Trade | Donnie Sadler | Cincinnati Reds | Kansas City Royals | Trade |
| Jun 19, 2001 | Signed as free agent | Ken Hill | — | Boston Red Sox | Free agent signing |
| Jun 19, 2001 | Released | Henry Rodriguez | New York Yankees | — | Release |
| Jun 19, 2001 | Trade | Ryan Christenson | Oakland Athletics | Arizona Diamondbacks | Trade |
| Jun 19, 2001 | Trade | Rob Ryan | Arizona Diamondbacks | Oakland Athletics | Trade |
| Jun 18, 2001 | Released | Ken Hill | Cincinnati Reds | — | Release |
| Jun 18, 2001 | Signed as free agent | Robert Perez | — | Milwaukee Brewers | Free agent signing |
| Jun 16, 2001 | Released | Wally Joyner | Anaheim Angels | — | Release |
| Jun 15, 2001 | Signed as free agent | Willie Blair | — | Detroit Tigers | Free agent signing |
| Jun 15, 2001 | Signed | Roy Corcoran | — | Montreal Expos | Amateur free agent signing |
| Jun 15, 2001 | Signed as free agent | Carlos Reyes | — | Arizona Diamondbacks | Free agent signing |
| Jun 15, 2001 | Trade | Ruben Mateo | Texas Rangers | Cincinnati Reds | Trade |
| Jun 15, 2001 | Trade | Edwin Encarnacion | Texas Rangers | Cincinnati Reds | Trade |
| Jun 15, 2001 | Trade | Rob Bell | Cincinnati Reds | Texas Rangers | Trade |
| Jun 14, 2001 | Released | Willie Blair | Cleveland Indians | — | Release |
| Jun 14, 2001 | Released | Greg Myers | Baltimore Orioles | — | Release |
| Jun 13, 2001 | Signed | Mauro Zarate | — | Florida Marlins | Amateur free agent signing |
| Jun 13, 2001 | Trade | Enrique Wilson | Pittsburgh Pirates | New York Yankees | Trade |
| Jun 13, 2001 | Trade | Damaso Marte | New York Yankees | Pittsburgh Pirates | Trade |
| Jun 12, 2001 | Signed as free agent | Rob Ducey | — | Montreal Expos | Free agent signing |
| Jun 12, 2001 | Released | Ramon Ramirez | San Diego Padres | — | Release |
| Jun 12, 2001 | Trade | Doug Mirabelli | Texas Rangers | Boston Red Sox | Trade |
| Jun 12, 2001 | Trade | Justin Duchscherer | Boston Red Sox | Texas Rangers | Trade |
| Jun 11, 2001 | Signed as free agent | John Wasdin | — | Baltimore Orioles | Free agent signing |
| Jun 9, 2001 | Signed | Lee Gronkiewicz | — | Cleveland Indians | Amateur free agent signing |
| Jun 9, 2001 | Released | Carlos Reyes | Oakland Athletics | — | Release |
| Jun 9, 2001 | Signed as free agent | Kevin Sefcik | — | Cleveland Indians | Free agent signing |
| Jun 8, 2001 | Released | Hector Almonte | Florida Marlins | — | Release |
| Jun 8, 2001 | Signed as free agent | Damon Buford | — | Baltimore Orioles | Free agent signing |
| Jun 8, 2001 | Signed as free agent | Tony Fernandez | — | Toronto Blue Jays | Free agent signing |
| Jun 8, 2001 | Signed as free agent | Pat Lennon | — | New York Yankees | Free agent signing |
| Jun 7, 2001 | Released | Rob Ducey | Philadelphia Phillies | — | Release |
| Jun 7, 2001 | Signed | Henry Owens | — | Pittsburgh Pirates | Amateur free agent signing |
| Jun 6, 2001 | Signed as free agent | Chris Peters | — | Cincinnati Reds | Free agent signing |
| Jun 6, 2001 | Signed as free agent | Jason Phillips | — | Cleveland Indians | Free agent signing |
| Jun 6, 2001 | Released | Kevin Sefcik | Colorado Rockies | — | Release |
| Jun 5, 2001 | Released | John Wasdin | Colorado Rockies | — | Release |
| Jun 5, 2001 | Trade | Paul Byrd | Philadelphia Phillies | Kansas City Royals | Trade |
| Jun 5, 2001 | Trade | Jose Santiago | Kansas City Royals | Philadelphia Phillies | Trade |
| Jun 4, 2001 | Released | Jason Phillips | Pittsburgh Pirates | — | Release |
| Jun 2, 2001 | Trade | Josh Bard | Colorado Rockies | Cleveland Indians | Trade |
| Jun 2, 2001 | Trade | Jody Gerut | Colorado Rockies | Cleveland Indians | Trade |
| Jun 2, 2001 | Trade | Jacob Cruz | Cleveland Indians | Colorado Rockies | Trade |
| Jun 1, 2001 | Released | Glenallen Hill | Anaheim Angels | — | Release |
| Jun 1, 2001 | Released | Pat Lennon | Toronto Blue Jays | — | Release |
| Jun 1, 2001 | Released | Dave Maurer | San Diego Padres | — | Release |
| Jun 1, 2001 | Signed as free agent | Dave Maurer | — | Cincinnati Reds | Free agent signing |
| Jun 1, 2001 | Signed | Jae Kuk Ryu | — | Chicago Cubs | Amateur free agent signing |
| Jun 1, 2001 | Signed as free agent | Matt Skrmetta | — | Cincinnati Reds | Free agent signing |
| Jun 1, 2001 | Trade | Jason Ryan | Pittsburgh Pirates | Los Angeles Dodgers | Trade |
| Jun 1, 2001 | Trade | Ruddy Lugo | Milwaukee Brewers | Los Angeles Dodgers | Trade |
| May 31, 2001 | Signed as free agent | Scott Forster | — | Cincinnati Reds | Free agent signing |
| May 30, 2001 | Signed as free agent | Tony Fiore | — | Minnesota Twins | Free agent signing |
| May 30, 2001 | Released | Chris Peters | Montreal Expos | — | Release |
| May 29, 2001 | Released | Jeff Brantley | Texas Rangers | — | Release |
| May 29, 2001 | Released | Tony Fernandez | Milwaukee Brewers | — | Release |
| May 28, 2001 | Signed | Greg Dobbs | — | Seattle Mariners | Amateur free agent signing |
| May 26, 2001 | Signed as free agent | Gus Gandarillas | — | Milwaukee Brewers | Free agent signing |
| May 25, 2001 | Released | Tony Fiore | Tampa Bay Devil Rays | — | Release |
| May 25, 2001 | Signed as free agent | Lyle Mouton | — | Detroit Tigers | Free agent signing |
| May 23, 2001 | Released | Trent Hubbard | Kansas City Royals | — | Release |
| May 23, 2001 | Released | Lyle Mouton | Florida Marlins | — | Release |
| May 21, 2001 | Released | Scott Forster | Milwaukee Brewers | — | Release |
| May 21, 2001 | Trade | Brian Jenkins | New York Mets | Cleveland Indians | Trade |
| May 20, 2001 | Signed as free agent | David Moraga | — | Chicago Cubs | Free agent signing |
| May 19, 2001 | Released | Mike Glavine | Atlanta Braves | — | Release |
| May 19, 2001 | Signed as free agent | Ron Mahay | — | Chicago Cubs | Free agent signing |
| May 19, 2001 | Trade | Justin Speier | Cleveland Indians | New York Mets | Trade |
| May 19, 2001 | Signed | Guilder Rodriguez | — | Milwaukee Brewers | Amateur free agent signing |
| May 18, 2001 | Signed as free agent | Ken Hill | — | Cincinnati Reds | Free agent signing |
| May 18, 2001 | Signed as free agent | Mark Watson | — | Cleveland Indians | Free agent signing |
| May 16, 2001 | Released | Damon Buford | Chicago Cubs | — | Release |
| May 16, 2001 | Released | Gus Gandarillas | Boston Red Sox | — | Release |
| May 15, 2001 | Signed | Mike Adams | — | Milwaukee Brewers | Amateur free agent signing |
| May 15, 2001 | Signed as free agent | Vinny Castilla | — | Houston Astros | Free agent signing |
| May 15, 2001 | Released | Ron Mahay | San Diego Padres | — | Release |
| May 14, 2001 | Signed as free agent | Nerio Rodriguez | — | Cleveland Indians | Free agent signing |
| May 14, 2001 | Signed | Jumbo Diaz | — | Los Angeles Dodgers | Amateur free agent signing |
| May 12, 2001 | Signed as free agent | Trent Durrington | — | Anaheim Angels | Free agent signing |
| May 12, 2001 | Signed as free agent | Joe Slusarski | — | Houston Astros | Free agent signing |
| May 11, 2001 | Released | Trent Durrington | Los Angeles Dodgers | — | Release |
| May 11, 2001 | Released | Joe Slusarski | Atlanta Braves | — | Release |
| May 11, 2001 | Signed as free agent | Dennis Springer | — | Los Angeles Dodgers | Free agent signing |
| May 10, 2001 | Released | Vinny Castilla | Tampa Bay Devil Rays | — | Release |
| May 10, 2001 | Signed as free agent | Aaron Small | — | Atlanta Braves | Free agent signing |
| May 9, 2001 | Signed as free agent | Doug Linton | — | New York Mets | Free agent signing |
| May 8, 2001 | Signed as free agent | Dan Serafini | — | New York Mets | Free agent signing |
| May 8, 2001 | Trade | Darwin Cubillan | Texas Rangers | Montreal Expos | Trade |
| May 8, 2001 | Trade | Mike Johnson | Montreal Expos | Texas Rangers | Trade |
| May 7, 2001 | Signed as free agent | Greg LaRocca | — | Cleveland Indians | Free agent signing |
| May 6, 2001 | Signed as free agent | Brian Banks | — | Florida Marlins | Free agent signing |
| May 4, 2001 | Released | Aaron Small | Anaheim Angels | — | Release |
| May 4, 2001 | Released | Mark Watson | Seattle Mariners | — | Release |
| May 3, 2001 | Signed as free agent | Ed Sprague | — | Seattle Mariners | Free agent signing |
| May 2, 2001 | Released | Brian Banks | Chicago Cubs | — | Release |
| May 2, 2001 | Signed as free agent | Marcus Jensen | — | Boston Red Sox | Free agent signing |
| May 1, 2001 | Signed | Alejandro De Aza | — | Los Angeles Dodgers | Amateur free agent signing |
| Apr 30, 2001 | Released | David Moraga | Colorado Rockies | — | Release |
| Apr 26, 2001 | Signed | Juan Morillo | — | Colorado Rockies | Amateur free agent signing |
| Apr 25, 2001 | Signed | Anderson Garcia | — | New York Yankees | Amateur free agent signing |
| Apr 25, 2001 | Signed | Ubaldo Jimenez | — | Colorado Rockies | Amateur free agent signing |
| Apr 24, 2001 | Signed as free agent | Jesse Orosco | — | Los Angeles Dodgers | Free agent signing |
| Apr 24, 2001 | Signed as free agent | Mandy Romero | — | Oakland Athletics | Free agent signing |
| Apr 24, 2001 | Released | Dan Serafini | San Francisco Giants | — | Release |
| Apr 23, 2001 | Released | Kirk Bullinger | Cleveland Indians | — | Release |
| Apr 23, 2001 | Signed as free agent | Jim Crowell | — | San Diego Padres | Free agent signing |
| Apr 23, 2001 | Signed | Anderson Hernandez | — | Detroit Tigers | Amateur free agent signing |
| Apr 23, 2001 | Signed | Miguel Montero | — | Arizona Diamondbacks | Amateur free agent signing |
| Apr 23, 2001 | Trade | Juan Sosa | Colorado Rockies | Arizona Diamondbacks | Trade |
| Apr 23, 2001 | Trade | Ryan Owens | Arizona Diamondbacks | Colorado Rockies | Trade |
| Apr 21, 2001 | Released | Melvin Nieves | Colorado Rockies | — | Release |
| Apr 20, 2001 | Signed as free agent | Scott Randall | — | Colorado Rockies | Free agent signing |
| Apr 20, 2001 | Trade | Jorge De Paula | Colorado Rockies | New York Yankees | Trade |
| Apr 19, 2001 | Signed | Armando Gabino | — | Cleveland Indians | Amateur free agent signing |
| Apr 19, 2001 | Released | Ken Hill | Tampa Bay Devil Rays | — | Release |
| Apr 19, 2001 | Released | Nerio Rodriguez | New York Mets | — | Release |
| Apr 18, 2001 | Signed as free agent | Scott Forster | — | Milwaukee Brewers | Free agent signing |
| Apr 18, 2001 | Signed as free agent | Bill Pulsipher | — | Boston Red Sox | Free agent signing |
| Apr 16, 2001 | Signed as free agent | Pat Lennon | — | Toronto Blue Jays | Free agent signing |
| Apr 16, 2001 | Signed as free agent | Mark Lewis | — | Cleveland Indians | Free agent signing |
| Apr 16, 2001 | Released | Kevin Pickford | Pittsburgh Pirates | — | Release |
| Apr 13, 2001 | Signed as free agent | Quinton McCracken | — | Minnesota Twins | Free agent signing |
| Apr 13, 2001 | Released | Mandy Romero | Florida Marlins | — | Release |
| Apr 13, 2001 | Signed as free agent | Masato Yoshii | — | Montreal Expos | Free agent signing |
| Apr 12, 2001 | Signed as free agent | Bernard Gilkey | — | Atlanta Braves | Free agent signing |
| Apr 11, 2001 | Signed as free agent | Ramon Martinez | — | Pittsburgh Pirates | Free agent signing |
| Apr 10, 2001 | Signed as free agent | Willie Blair | — | Cleveland Indians | Free agent signing |
| Apr 9, 2001 | Signed as free agent | David Lamb | — | Colorado Rockies | Free agent signing |
| Apr 9, 2001 | Signed as free agent | Brian McNichol | — | Cincinnati Reds | Free agent signing |
| Apr 8, 2001 | Signed as free agent | Rich Rodriguez | — | Cleveland Indians | Free agent signing |
| Apr 6, 2001 | Signed as free agent | Ryan Thompson | — | Florida Marlins | Free agent signing |
| Apr 5, 2001 | Signed as free agent | Todd Greene | — | New York Yankees | Free agent signing |
| Apr 5, 2001 | Signed as free agent | F. P. Santangelo | — | Oakland Athletics | Free agent signing |
| Apr 4, 2001 | Signed as free agent | Bobby Witt | — | Arizona Diamondbacks | Free agent signing |
| Apr 4, 2001 | Trade | Juan Acevedo | Milwaukee Brewers | Colorado Rockies | Trade |
| Apr 4, 2001 | Trade | Kane Davis | Milwaukee Brewers | Colorado Rockies | Trade |
| Apr 4, 2001 | Trade | Jose Flores | Milwaukee Brewers | Colorado Rockies | Trade |
| Apr 4, 2001 | Trade | Mark Leiter | Colorado Rockies | Milwaukee Brewers | Trade |
| Apr 4, 2001 | Trade | Mike DeJean | Colorado Rockies | Milwaukee Brewers | Trade |
| Apr 4, 2001 | Trade | Elvis Peña | Colorado Rockies | Milwaukee Brewers | Trade |
| Apr 3, 2001 | Released | Bernard Gilkey | St. Louis Cardinals | — | Release |
| Apr 3, 2001 | Signed as free agent | Jerry Spradlin | — | St. Louis Cardinals | Free agent signing |
| Apr 3, 2001 | Signed as free agent | Billy Taylor | — | Pittsburgh Pirates | Free agent signing |
| Apr 2, 2001 | Signed as free agent | Lyle Mouton | — | Florida Marlins | Free agent signing |
| Apr 2, 2001 | Released | Billy Taylor | Pittsburgh Pirates | — | Release |
| Apr 2, 2001 | Released | Ryan Thompson | Toronto Blue Jays | — | Release |
| Apr 2, 2001 | Released | Ed Yarnall | Cincinnati Reds | — | Release |
| Apr 2, 2001 | Signed as free agent | Willie Banks | — | Toronto Blue Jays | Free agent signing |
| Apr 1, 2001 | Signed as free agent | Brandon Knight | — | New York Yankees | Free agent signing |
| Apr 1, 2001 | Released | Doug Linton | Los Angeles Dodgers | — | Release |
| Apr 1, 2001 | Released | Yorkis Perez | Los Angeles Dodgers | — | Release |
| Apr 1, 2001 | Signed as free agent | Joe Slusarski | — | Atlanta Braves | Free agent signing |
| Mar 31, 2001 | Released | Willie Blair | Cleveland Indians | — | Release |
| Mar 31, 2001 | Released | Eric DuBose | Detroit Tigers | — | Release |
| Mar 31, 2001 | Signed as free agent | Chris Hammond | — | Cleveland Indians | Free agent signing |
| Mar 31, 2001 | Released | Jerry Spradlin | Cleveland Indians | — | Release |
| Mar 31, 2001 | Trade | Mickey Lopez | Milwaukee Brewers | Philadelphia Phillies | Trade |
| Mar 30, 2001 | Released | Steve Avery | Atlanta Braves | — | Release |
| Mar 30, 2001 | Released | Carlos Baerga | Seattle Mariners | — | Release |
| Mar 30, 2001 | Signed as free agent | Hector Carrasco | — | Minnesota Twins | Free agent signing |
| Mar 30, 2001 | Released | Jim Crowell | St. Louis Cardinals | — | Release |
| Mar 30, 2001 | Released | Matt Duff | Pittsburgh Pirates | — | Release |
| Mar 30, 2001 | Released | Scott Forster | New York Mets | — | Release |
| Mar 30, 2001 | Released | Brian Hunter | Philadelphia Phillies | — | Release |
| Mar 30, 2001 | Released | Brandon Knight | New York Yankees | — | Release |
| Mar 30, 2001 | Trade | Nelson Lara | Florida Marlins | Boston Red Sox | Trade |
| Mar 30, 2001 | Trade | Craig Dingman | New York Yankees | Colorado Rockies | Trade |
| Mar 30, 2001 | Trade | Oswaldo Mairena | Chicago Cubs | Florida Marlins | Trade |
| Mar 30, 2001 | Trade | Manny Aybar | Florida Marlins | Chicago Cubs | Trade |
| Mar 30, 2001 | Trade | Mike Curry | Kansas City Royals | New York Mets | Trade |
| Mar 30, 2001 | Trade | Endy Chavez | New York Mets | Kansas City Royals | Trade |
| Mar 29, 2001 | Released | David Lamb | Anaheim Angels | — | Release |
| Mar 29, 2001 | Released | Brian McNichol | Chicago Cubs | — | Release |
| Mar 29, 2001 | Signed | Terry Pearson | — | Detroit Tigers | Amateur free agent signing |
| Mar 29, 2001 | Signed as free agent | Ariel Prieto | — | Tampa Bay Devil Rays | Free agent signing |
| Mar 29, 2001 | Released | Rich Rodriguez | New York Mets | — | Release |
| Mar 29, 2001 | Released | F. P. Santangelo | Los Angeles Dodgers | — | Release |
| Mar 28, 2001 | Released | Jose Canseco | Anaheim Angels | — | Release |
| Mar 28, 2001 | Released | Hector Carrasco | Toronto Blue Jays | — | Release |
| Mar 28, 2001 | Released | Rick DeHart | Los Angeles Dodgers | — | Release |
| Mar 28, 2001 | Signed as free agent | Mike Duvall | — | Minnesota Twins | Free agent signing |
| Mar 28, 2001 | Signed as free agent | Derrin Ebert | — | Boston Red Sox | Free agent signing |
| Mar 28, 2001 | Released | Todd Greene | Toronto Blue Jays | — | Release |
| Mar 28, 2001 | Released | Marc Kroon | Los Angeles Dodgers | — | Release |
| Mar 28, 2001 | Released | Greg LaRocca | San Diego Padres | — | Release |
| Mar 28, 2001 | Released | Ramon Martinez | Los Angeles Dodgers | — | Release |
| Mar 28, 2001 | Released | Quinton McCracken | St. Louis Cardinals | — | Release |
| Mar 28, 2001 | Released | Kent Mercker | Boston Red Sox | — | Release |
| Mar 28, 2001 | Signed as free agent | Scott Servais | — | Houston Astros | Free agent signing |
| Mar 28, 2001 | Released | Ed Sprague | San Diego Padres | — | Release |
| Mar 28, 2001 | Released | Masato Yoshii | Colorado Rockies | — | Release |
| Mar 28, 2001 | Trade | Darren Blakely | Anaheim Angels | New York Yankees | Trade |
| Mar 28, 2001 | Trade | Glenallen Hill | New York Yankees | Anaheim Angels | Trade |
| Mar 28, 2001 | Trade | Miguel Cairo | Oakland Athletics | Chicago Cubs | Trade |
| Mar 28, 2001 | Trade | Eric Hinske | Chicago Cubs | Oakland Athletics | Trade |
| Mar 28, 2001 | Trade | Chad Moeller | Minnesota Twins | Arizona Diamondbacks | Trade |
| Mar 28, 2001 | Trade | Hanley Frias | Arizona Diamondbacks | Minnesota Twins | Trade |
| Mar 28, 2001 | Trade | Cesar Crespo | Florida Marlins | San Diego Padres | Trade |
| Mar 28, 2001 | Trade | Mark Kotsay | Florida Marlins | San Diego Padres | Trade |
| Mar 28, 2001 | Trade | Matt Clement | San Diego Padres | Florida Marlins | Trade |
| Mar 28, 2001 | Trade | Eric Owens | San Diego Padres | Florida Marlins | Trade |
| Mar 28, 2001 | Trade | Omar Ortiz | San Diego Padres | Florida Marlins | Trade |
| Mar 27, 2001 | Signed as free agent | Brad Clontz | — | Colorado Rockies | Free agent signing |
| Mar 27, 2001 | Released | Ariel Prieto | Cleveland Indians | — | Release |
| Mar 27, 2001 | Signed as free agent | Dan Serafini | — | San Francisco Giants | Free agent signing |
| Mar 26, 2001 | Released | Nate Bland | San Diego Padres | — | Release |
| Mar 26, 2001 | Released | Chris Haney | Texas Rangers | — | Release |
| Mar 26, 2001 | Released | Reggie Harris | Pittsburgh Pirates | — | Release |
| Mar 26, 2001 | Released | Scott Randall | Texas Rangers | — | Release |
| Mar 26, 2001 | Trade | Brian Rose | Colorado Rockies | New York Mets | Trade |
| Mar 26, 2001 | Trade | Mark Leiter | New York Mets | Colorado Rockies | Trade |
| Mar 25, 2001 | Trade | Unnamed | Anaheim Angels | Chicago Cubs | $ |
| Mar 25, 2001 | Trade | Jose Nieves | Chicago Cubs | Anaheim Angels | Trade |
| Mar 25, 2001 | Trade | Mike Fyhrie | Anaheim Angels | Chicago Cubs | Trade |
| Mar 24, 2001 | Released | Mark Lewis | Los Angeles Dodgers | — | Release |
| Mar 24, 2001 | Released | Bobby Madritsch | Cincinnati Reds | — | Release |
| Mar 24, 2001 | Released | Randy Williams | Chicago Cubs | — | Release |
| Mar 24, 2001 | Trade | Carlos Almanzar | San Diego Padres | New York Yankees | Trade |
| Mar 24, 2001 | Trade | David Lee | New York Yankees | San Diego Padres | Trade |
| Mar 23, 2001 | Released | Derrin Ebert | Tampa Bay Devil Rays | — | Release |
| Mar 23, 2001 | Signed as free agent | Trent Hubbard | — | Kansas City Royals | Free agent signing |
| Mar 23, 2001 | Signed as free agent | Chris Petersen | — | Pittsburgh Pirates | Free agent signing |
| Mar 23, 2001 | Released | Bill Pulsipher | Tampa Bay Devil Rays | — | Release |
| Mar 23, 2001 | Released | Scott Servais | Detroit Tigers | — | Release |
| Mar 22, 2001 | Released | Mike Duvall | Tampa Bay Devil Rays | — | Release |
| Mar 21, 2001 | Signed as free agent | Calvin Maduro | — | Baltimore Orioles | Free agent signing |
| Mar 21, 2001 | Released | Chris Petersen | Cleveland Indians | — | Release |
| Mar 21, 2001 | Signed as free agent | Ruben Rivera | — | Cincinnati Reds | Free agent signing |
| Mar 21, 2001 | Trade | Drew Henson | Cincinnati Reds | New York Yankees | Trade |
| Mar 21, 2001 | Trade | Michael Coleman | Cincinnati Reds | New York Yankees | Trade |
| Mar 21, 2001 | Trade | Wily Mo Peña | New York Yankees | Cincinnati Reds | Trade |
| Mar 20, 2001 | Released | Dan Serafini | Pittsburgh Pirates | — | Release |
| Mar 20, 2001 | Trade | Mike Williams | Toronto Blue Jays | Chicago White Sox | Trade |
| Mar 20, 2001 | Trade | Matt DeWitt | Chicago White Sox | Toronto Blue Jays | Trade |
| Mar 19, 2001 | Signed as free agent | Rickey Henderson | — | San Diego Padres | Free agent signing |
| Mar 19, 2001 | Trade | Mike Rupp | Boston Red Sox | Chicago White Sox | Trade |
| Mar 17, 2001 | Signed as free agent | Sean Bergman | — | Colorado Rockies | Free agent signing |
| Mar 17, 2001 | Released | Trent Hubbard | Toronto Blue Jays | — | Release |
| Mar 17, 2001 | Signed as free agent | Benito Santiago | — | San Francisco Giants | Free agent signing |
| Mar 17, 2001 | Trade | Antonio Osuna | Los Angeles Dodgers | Chicago White Sox | Trade |
| Mar 17, 2001 | Trade | Carlos Ortega | Los Angeles Dodgers | Chicago White Sox | Trade |
| Mar 17, 2001 | Trade | Gary Majewski | Chicago White Sox | Los Angeles Dodgers | Trade |
| Mar 17, 2001 | Trade | Orlando Rodriguez | Chicago White Sox | Los Angeles Dodgers | Trade |
| Mar 17, 2001 | Trade | Andre Simpson | Chicago White Sox | Los Angeles Dodgers | Trade |
| Mar 15, 2001 | Released | Sean Bergman | Tampa Bay Devil Rays | — | Release |
| Mar 14, 2001 | Released | Bob Henley | Montreal Expos | — | Release |
| Mar 14, 2001 | Released | Ruben Rivera | San Diego Padres | — | Release |
| Mar 13, 2001 | Released | Geremi Gonzalez | Chicago Cubs | — | Release |
| Mar 13, 2001 | Released | Mike Romano | Atlanta Braves | — | Release |
| Mar 13, 2001 | Released | Scott Service | Los Angeles Dodgers | — | Release |
| Mar 8, 2001 | Signed as free agent | Mike Mohler | — | Arizona Diamondbacks | Free agent signing |
| Mar 6, 2001 | Signed as free agent | Tony Tarasco | — | New York Mets | Free agent signing |
| Mar 5, 2001 | Signed as free agent | Mark Lewis | — | Los Angeles Dodgers | Free agent signing |
| Mar 2, 2001 | Released | Joe Depastino | New York Mets | — | Release |
| Feb 28, 2001 | Signed as free agent | Matt Beech | — | Texas Rangers | Free agent signing |
| Feb 25, 2001 | Signed as free agent | Rudy Seanez | — | San Diego Padres | Free agent signing |
| Feb 24, 2001 | Signed as free agent | Carlos Reyes | — | Oakland Athletics | Free agent signing |
| Feb 24, 2001 | Trade | Devon White | Los Angeles Dodgers | Milwaukee Brewers | Trade |
| Feb 24, 2001 | Trade | Marquis Grissom | Milwaukee Brewers | Los Angeles Dodgers | Trade |
| Feb 23, 2001 | Signed as free agent | Damon Hollins | — | Minnesota Twins | Free agent signing |
| Feb 20, 2001 | Signed | Jesus Delgado | — | Boston Red Sox | Amateur free agent signing |
| Feb 20, 2001 | Signed as free agent | Jeff Reboulet | — | Los Angeles Dodgers | Free agent signing |
| Feb 19, 2001 | Signed as free agent | Tim Byrdak | — | Cleveland Indians | Free agent signing |
| Feb 19, 2001 | Signed as free agent | Ben Ford | — | Chicago Cubs | Free agent signing |
| Feb 19, 2001 | Signed as free agent | Deion Sanders | — | Cincinnati Reds | Free agent signing |
| Feb 18, 2001 | Signed as free agent | Manny Alexander | — | Seattle Mariners | Free agent signing |
| Feb 16, 2001 | Signed | Alberto Callaspo | — | Anaheim Angels | Amateur free agent signing |
| Feb 15, 2001 | Signed as free agent | Bobby Jones | — | San Diego Padres | Free agent signing |
| Feb 15, 2001 | Signed as free agent | Henry Rodriguez | — | New York Yankees | Free agent signing |
| Feb 14, 2001 | Signed | Jairo Asencio | — | Pittsburgh Pirates | Amateur free agent signing |
| Feb 13, 2001 | Signed as free agent | Mike Caruso | — | Tampa Bay Devil Rays | Free agent signing |
| Feb 13, 2001 | Signed as free agent | Andrew Lorraine | — | Florida Marlins | Free agent signing |
| Feb 13, 2001 | Signed | Martin Prado | — | Atlanta Braves | Amateur free agent signing |
| Feb 12, 2001 | Signed | Arturo Lopez | — | Los Angeles Dodgers | Amateur free agent signing |
| Feb 12, 2001 | Signed as free agent | Mike Oquist | — | Minnesota Twins | Free agent signing |
| Feb 10, 2001 | Signed as free agent | Ariel Prieto | — | Cleveland Indians | Free agent signing |
| Feb 9, 2001 | Signed as free agent | Matt Walbeck | — | Cincinnati Reds | Free agent signing |
| Feb 9, 2001 | Signed as free agent | Jamie Walker | — | Cleveland Indians | Free agent signing |
| Feb 8, 2001 | Signed as free agent | Willie Blair | — | Cleveland Indians | Free agent signing |
| Feb 8, 2001 | Signed as free agent | Kirk Bullinger | — | Cleveland Indians | Free agent signing |
| Feb 8, 2001 | Signed as free agent | Tony Fernandez | — | Milwaukee Brewers | Free agent signing |
| Feb 8, 2001 | Signed as free agent | Ken Hill | — | Tampa Bay Devil Rays | Free agent signing |
| Feb 8, 2001 | Signed as free agent | David Lundquist | — | San Diego Padres | Free agent signing |
| Feb 8, 2001 | Signed as free agent | Jesse Orosco | — | Los Angeles Dodgers | Free agent signing |
| Feb 8, 2001 | Signed as free agent | Chris Petersen | — | Cleveland Indians | Free agent signing |
| Feb 7, 2001 | Signed | Trent Oeltjen | — | Minnesota Twins | Amateur free agent signing |
| Feb 7, 2001 | Signed as free agent | Dante Powell | — | San Francisco Giants | Free agent signing |
| Feb 7, 2001 | Signed as free agent | J. D. Smart | — | Texas Rangers | Free agent signing |
| Feb 7, 2001 | Signed as free agent | Jerry Spradlin | — | Cleveland Indians | Free agent signing |
| Feb 6, 2001 | Signed | Edwar Ramirez | — | Anaheim Angels | Amateur free agent signing |
| Feb 6, 2001 | Signed as free agent | Jeff Tabaka | — | St. Louis Cardinals | Free agent signing |
| Feb 4, 2001 | Signed as free agent | Jed Hansen | — | Kansas City Royals | Free agent signing |
| Feb 3, 2001 | Signed as free agent | Mike Lincoln | — | Pittsburgh Pirates | Free agent signing |
| Feb 2, 2001 | Signed as free agent | Matt Franco | — | New York Mets | Free agent signing |
| Feb 2, 2001 | Signed as free agent | Jose Parra | — | Pittsburgh Pirates | Free agent signing |
| Feb 1, 2001 | Signed as free agent | Jamie Arnold | — | San Francisco Giants | Free agent signing |
| Feb 1, 2001 | Signed as free agent | Billy Taylor | — | Pittsburgh Pirates | Free agent signing |
| Jan 31, 2001 | Signed as free agent | Rusty Meacham | — | Tampa Bay Devil Rays | Free agent signing |
| Jan 30, 2001 | Signed as free agent | Roy Smith | — | Cleveland Indians | Free agent signing |
| Jan 29, 2001 | Signed as free agent | Paul Byrd | — | Philadelphia Phillies | Free agent signing |
| Jan 29, 2001 | Signed as free agent | Todd Erdos | — | Boston Red Sox | Free agent signing |
| Jan 29, 2001 | Signed as free agent | Gus Gandarillas | — | Boston Red Sox | Free agent signing |
| Jan 29, 2001 | Signed as free agent | Adam Melhuse | — | Colorado Rockies | Free agent signing |
| Jan 29, 2001 | Signed as free agent | Melvin Nieves | — | Colorado Rockies | Free agent signing |
| Jan 29, 2001 | Released | Salomon Torres | Montreal Expos | — | Release |
| Jan 29, 2001 | Signed as free agent | Rick Wilkins | — | San Diego Padres | Free agent signing |
| Jan 27, 2001 | Signed as free agent | Marc Valdes | — | Atlanta Braves | Free agent signing |
| Jan 27, 2001 | Signed as free agent | Matt Whiteside | — | Atlanta Braves | Free agent signing |
| Jan 26, 2001 | Signed as free agent | Luis Alicea | — | Kansas City Royals | Free agent signing |
| Jan 26, 2001 | Signed as free agent | Steve Avery | — | Atlanta Braves | Free agent signing |
| Jan 26, 2001 | Signed as free agent | Butch Huskey | — | Cleveland Indians | Free agent signing |
| Jan 26, 2001 | Signed as free agent | Alex Rodriguez | — | Texas Rangers | Free agent signing |
| Jan 25, 2001 | Signed as free agent | Wally Joyner | — | Anaheim Angels | Free agent signing |
| Jan 24, 2001 | Signed | Alfredo Aceves | — | Toronto Blue Jays | Amateur free agent signing |
| Jan 24, 2001 | Signed as free agent | Brian Falkenborg | — | Seattle Mariners | Free agent signing |
| Jan 24, 2001 | Signed as free agent | Deion Sanders | — | Cincinnati Reds | Free agent signing |
| Jan 24, 2001 | Signed as free agent | Stan Spencer | — | San Diego Padres | Free agent signing |
| Jan 24, 2001 | Signed as free agent | Don Wengert | — | Pittsburgh Pirates | Free agent signing |
| Jan 23, 2001 | Signed as free agent | Carlos Baerga | — | Seattle Mariners | Free agent signing |
| Jan 22, 2001 | Signed as free agent | Justin Atchley | — | Cincinnati Reds | Free agent signing |
| Jan 22, 2001 | Signed as free agent | Raul Ibanez | — | Kansas City Royals | Free agent signing |
| Jan 22, 2001 | Signed as free agent | Trever Miller | — | Boston Red Sox | Free agent signing |
| Jan 22, 2001 | Signed as free agent | Pedro Swann | — | Atlanta Braves | Free agent signing |
| Jan 20, 2001 | Signed as free agent | Brendan Donnelly | — | Anaheim Angels | Free agent signing |
| Jan 20, 2001 | Signed as free agent | Scott Radinsky | — | Cleveland Indians | Free agent signing |
| Jan 19, 2001 | Signed as free agent | Craig Grebeck | — | Boston Red Sox | Free agent signing |
| Jan 19, 2001 | Signed as free agent | Jason Grimsley | — | Kansas City Royals | Free agent signing |
| Jan 19, 2001 | Signed as free agent | Reggie Harris | — | Pittsburgh Pirates | Free agent signing |
| Jan 19, 2001 | Released | Ariel Prieto | Oakland Athletics | — | Release |
| Jan 18, 2001 | Signed as free agent | Ramon Martinez | — | Los Angeles Dodgers | Free agent signing |
| Jan 18, 2001 | Signed as free agent | Heath Murray | — | Detroit Tigers | Free agent signing |
| Jan 18, 2001 | Trade | Frank Graham | New York Mets | Boston Red Sox | Trade |
| Jan 18, 2001 | Trade | Rich Croushore | Boston Red Sox | New York Mets | Trade |
| Jan 17, 2001 | Signed as free agent | Tim Bogar | — | Los Angeles Dodgers | Free agent signing |
| Jan 17, 2001 | Signed as free agent | Jeremy Powell | — | San Diego Padres | Free agent signing |
| Jan 16, 2001 | Signed as free agent | Jose Canseco | — | Anaheim Angels | Free agent signing |
| Jan 16, 2001 | Signed as free agent | Jeff Reed | — | Chicago Cubs | Free agent signing |
| Jan 16, 2001 | Signed | Argenis Reyes | — | Cleveland Indians | Amateur free agent signing |
| Jan 16, 2001 | Signed as free agent | Frankie Rodriguez | — | Cincinnati Reds | Free agent signing |
| Jan 16, 2001 | Signed as free agent | Scott Servais | — | Detroit Tigers | Free agent signing |
| Jan 15, 2001 | Signed as free agent | Mike Garcia | — | Pittsburgh Pirates | Free agent signing |
| Jan 15, 2001 | Signed as free agent | Doug Linton | — | Los Angeles Dodgers | Free agent signing |
| Jan 15, 2001 | Signed as free agent | Jose Molina | — | Anaheim Angels | Free agent signing |
| Jan 15, 2001 | Signed as free agent | Dusty Wathan | — | Florida Marlins | Free agent signing |
| Jan 14, 2001 | Signed as free agent | Johnny Ruffin | — | Florida Marlins | Free agent signing |
| Jan 14, 2001 | Trade | Matt DeWitt | Toronto Blue Jays | Chicago White Sox | Trade |
| Jan 14, 2001 | Trade | David Wells | Toronto Blue Jays | Chicago White Sox | Trade |
| Jan 14, 2001 | Trade | Kevin Beirne | Chicago White Sox | Toronto Blue Jays | Trade |
| Jan 14, 2001 | Trade | Brian Simmons | Chicago White Sox | Toronto Blue Jays | Trade |
| Jan 14, 2001 | Trade | Mike Sirotka | Chicago White Sox | Toronto Blue Jays | Trade |
| Jan 14, 2001 | Trade | Mike Williams | Chicago White Sox | Toronto Blue Jays | Trade |
| Jan 13, 2001 | Signed as free agent | Rick DeHart | — | Los Angeles Dodgers | Free agent signing |
| Jan 13, 2001 | Signed as free agent | Mike Porzio | — | Chicago White Sox | Free agent signing |
| Jan 12, 2001 | Signed as free agent | Andy Barkett | — | Pittsburgh Pirates | Free agent signing |
| Jan 12, 2001 | Signed as free agent | Jeff Brantley | — | Texas Rangers | Free agent signing |
| Jan 12, 2001 | Signed as free agent | Jim Bullinger | — | St. Louis Cardinals | Free agent signing |
| Jan 12, 2001 | Signed as free agent | Roberto Kelly | — | Colorado Rockies | Free agent signing |
| Jan 12, 2001 | Released | Heathcliff Slocumb | San Diego Padres | — | Release |
| Jan 12, 2001 | Signed as free agent | Marc Wilkins | — | Pittsburgh Pirates | Free agent signing |
| Jan 11, 2001 | Signed as free agent | Israel Alcantara | — | Boston Red Sox | Free agent signing |
| Jan 11, 2001 | Signed as free agent | Brant Brown | — | Milwaukee Brewers | Free agent signing |
| Jan 11, 2001 | Signed as free agent | David Cone | — | Boston Red Sox | Free agent signing |
| Jan 11, 2001 | Signed as free agent | Eric Davis | — | San Francisco Giants | Free agent signing |
| Jan 11, 2001 | Signed as free agent | Joe Depastino | — | New York Mets | Free agent signing |
| Jan 11, 2001 | Signed as free agent | Tom Evans | — | Detroit Tigers | Free agent signing |
| Jan 11, 2001 | Released | Jeff Harris | Minnesota Twins | — | Release |
| Jan 11, 2001 | Signed as free agent | Pat Mahomes | — | Texas Rangers | Free agent signing |
| Jan 11, 2001 | Signed as free agent | Reggie Sanders | — | Arizona Diamondbacks | Free agent signing |
| Jan 11, 2001 | Signed as free agent | Kevin Sefcik | — | Colorado Rockies | Free agent signing |
| Jan 11, 2001 | Trade | Javier Ochoa | New York Mets | Cleveland Indians | Trade |
| Jan 11, 2001 | Trade | Tom Martin | Cleveland Indians | New York Mets | Trade |
| Jan 10, 2001 | Signed as free agent | Ron Coomer | — | Chicago Cubs | Free agent signing |
| Jan 10, 2001 | Signed as free agent | Jose Fernandez | — | Anaheim Angels | Free agent signing |
| Jan 10, 2001 | Signed as free agent | Chris Haney | — | Texas Rangers | Free agent signing |
| Jan 10, 2001 | Signed as free agent | Brian Hunter | — | Philadelphia Phillies | Free agent signing |
| Jan 10, 2001 | Signed as free agent | Gabe Molina | — | Florida Marlins | Free agent signing |
| Jan 10, 2001 | Signed as free agent | Chris Peters | — | Montreal Expos | Free agent signing |
| Jan 10, 2001 | Signed as free agent | Kelly Stinnett | — | Cincinnati Reds | Free agent signing |
| Jan 10, 2001 | Signed as free agent | Jeff Wallace | — | Tampa Bay Devil Rays | Free agent signing |
| Jan 10, 2001 | Signed as free agent | Jason Wood | — | Pittsburgh Pirates | Free agent signing |
| Jan 9, 2001 | Released | Justin Atchley | Cincinnati Reds | — | Release |
| Jan 9, 2001 | Signed as free agent | Darren Bragg | — | New York Mets | Free agent signing |
| Jan 9, 2001 | Signed as free agent | Hector Carrasco | — | Toronto Blue Jays | Free agent signing |
| Jan 9, 2001 | Signed as free agent | Todd Dunwoody | — | Chicago Cubs | Free agent signing |
| Jan 9, 2001 | Signed as free agent | Juan Gonzalez | — | Cleveland Indians | Free agent signing |
| Jan 9, 2001 | Signed as free agent | Wilton Guerrero | — | Cincinnati Reds | Free agent signing |
| Jan 9, 2001 | Signed as free agent | Thomas Howard | — | Pittsburgh Pirates | Free agent signing |
| Jan 9, 2001 | Signed as free agent | Mark Leiter | — | New York Mets | Free agent signing |
| Jan 9, 2001 | Signed as free agent | Jason Phillips | — | Pittsburgh Pirates | Free agent signing |
| Jan 9, 2001 | Signed as free agent | John Wehner | — | Pittsburgh Pirates | Free agent signing |
| Jan 8, 2001 | Signed as free agent | Kurt Abbott | — | Atlanta Braves | Free agent signing |
| Jan 8, 2001 | Signed as free agent | Harold Baines | — | Chicago White Sox | Free agent signing |
| Jan 8, 2001 | Signed as free agent | Jose Flores | — | Milwaukee Brewers | Free agent signing |
| Jan 8, 2001 | Signed as free agent | Mike Gulan | — | Florida Marlins | Free agent signing |
| Jan 8, 2001 | Signed as free agent | Mendy Lopez | — | Houston Astros | Free agent signing |
| Jan 8, 2001 | Signed as free agent | Jason McDonald | — | Milwaukee Brewers | Free agent signing |
| Jan 8, 2001 | Signed as free agent | Walt McKeel | — | Colorado Rockies | Free agent signing |
| Jan 8, 2001 | Signed as free agent | Orlando Merced | — | Houston Astros | Free agent signing |
| Jan 8, 2001 | Signed as free agent | Scott Pose | — | Houston Astros | Free agent signing |
| Jan 8, 2001 | Signed as free agent | Brad Rigby | — | Houston Astros | Free agent signing |
| Jan 8, 2001 | Trade | Roberto Hernandez | Tampa Bay Devil Rays | Kansas City Royals | Trade |
| Jan 8, 2001 | Trade | Cory Lidle | Tampa Bay Devil Rays | Oakland Athletics | Trade |
| Jan 8, 2001 | Trade | Ben Grieve | Oakland Athletics | Tampa Bay Devil Rays | Trade |
| Jan 8, 2001 | Trade | Johnny Damon | Kansas City Royals | Oakland Athletics | Trade |
| Jan 8, 2001 | Trade | Mark Ellis | Kansas City Royals | Oakland Athletics | Trade |
| Jan 8, 2001 | Trade | Angel Berroa | Oakland Athletics | Kansas City Royals | Trade |
| Jan 8, 2001 | Trade | A. J. Hinch | Oakland Athletics | Kansas City Royals | Trade |
| Jan 7, 2001 | Signed as free agent | Miguel Cairo | — | Oakland Athletics | Free agent signing |
| Jan 5, 2001 | Signed as free agent | Shane Andrews | — | St. Louis Cardinals | Free agent signing |
| Jan 5, 2001 | Signed as free agent | Bobby Bonilla | — | St. Louis Cardinals | Free agent signing |
| Jan 5, 2001 | Signed | Robinson Cano | — | New York Yankees | Amateur free agent signing |
| Jan 5, 2001 | Signed as free agent | Bernard Gilkey | — | St. Louis Cardinals | Free agent signing |
| Jan 5, 2001 | Signed as free agent | Mark Guthrie | — | Oakland Athletics | Free agent signing |
| Jan 5, 2001 | Signed as free agent | Kevin Jarvis | — | San Diego Padres | Free agent signing |
| Jan 5, 2001 | Signed as free agent | Kevin Jordan | — | Philadelphia Phillies | Free agent signing |
| Jan 5, 2001 | Signed as free agent | John Mabry | — | St. Louis Cardinals | Free agent signing |
| Jan 5, 2001 | Signed as free agent | Dave Magadan | — | San Diego Padres | Free agent signing |
| Jan 5, 2001 | Signed as free agent | Kent Mercker | — | Boston Red Sox | Free agent signing |
| Jan 5, 2001 | Signed as free agent | Greg Norton | — | Colorado Rockies | Free agent signing |
| Jan 5, 2001 | Signed as free agent | Steve Ontiveros | — | New York Mets | Free agent signing |
| Jan 5, 2001 | Signed as free agent | Jorge Velandia | — | New York Mets | Free agent signing |
| Jan 5, 2001 | Signed as free agent | Bryan Ward | — | Boston Red Sox | Free agent signing |
| Jan 4, 2001 | Signed as free agent | Benito Baez | — | Florida Marlins | Free agent signing |
| Jan 4, 2001 | Signed as free agent | Giovanni Carrara | — | Los Angeles Dodgers | Free agent signing |
| Jan 4, 2001 | Signed as free agent | Shawn Gilbert | — | Los Angeles Dodgers | Free agent signing |
| Jan 4, 2001 | Signed as free agent | Chris Turner | — | Philadelphia Phillies | Free agent signing |
| Jan 4, 2001 | Signed as free agent | Ismael Valdez | — | Anaheim Angels | Free agent signing |
| Jan 4, 2001 | Signed as free agent | Brian Williams | — | Boston Red Sox | Free agent signing |
| Jan 3, 2001 | Signed as free agent | Kent Bottenfield | — | Houston Astros | Free agent signing |
| Jan 3, 2001 | Signed as free agent | Jim Mann | — | Houston Astros | Free agent signing |
| Jan 3, 2001 | Signed | Anibal Sanchez | — | Boston Red Sox | Amateur free agent signing |
| Jan 3, 2001 | Signed as free agent | Mark Sweeney | — | Milwaukee Brewers | Free agent signing |
| Jan 3, 2001 | Signed as free agent | Todd Williams | — | New York Yankees | Free agent signing |
| Jan 3, 2001 | Trade | Jay Tessmer | New York Yankees | Colorado Rockies | Trade |
| Jan 3, 2001 | Trade | Seth Taylor | New York Yankees | Colorado Rockies | Trade |
| Jan 3, 2001 | Trade | David Lee | Colorado Rockies | New York Yankees | Trade |
| Jan 2, 2001 | Signed as free agent | Cory Bailey | — | Kansas City Royals | Free agent signing |
| Jan 2, 2001 | Signed as free agent | Charlie Hayes | — | Houston Astros | Free agent signing |
| Jan 1, 2001 | Signed as free agent | Chris Nichting | — | Cincinnati Reds | Free agent signing |
| Jan 1, 2001 | Signed as free agent | Tim Spehr | — | Cincinnati Reds | Free agent signing |
Every row is mapped onto the same trade / signing / release vocabulary the modern feed uses, with the era’s own type description kept on each row. Club names are the names of the day (the Boston Braves years, the Brooklyn Dodgers years), and each links to the franchise it is today. Some dates are only partially known or flagged approximate by the source; they are shown exactly as published, never completed to a fake precise day.